ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.61390629
2	DNA deamination (GO:0045006)	5.42382649
3	ATP synthesis coupled proton transport (GO:0015986)	4.30138074
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.30138074
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.21807871
6	viral transcription (GO:0019083)	4.08019035
7	translational termination (GO:0006415)	3.96878428
8	cytidine metabolic process (GO:0046087)	3.93534776
9	cytidine catabolic process (GO:0006216)	3.93534776
10	cytidine deamination (GO:0009972)	3.93534776
11	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.70177027
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.70177027
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.70093862
14	ribosomal large subunit biogenesis (GO:0042273)	3.68334464
15	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.67137022
16	cotranslational protein targeting to membrane (GO:0006613)	3.62695104
17	protein targeting to ER (GO:0045047)	3.60369612
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.60355287
19	translational elongation (GO:0006414)	3.58912059
20	protein localization to endoplasmic reticulum (GO:0070972)	3.46354763
21	protein complex biogenesis (GO:0070271)	3.45280320
22	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.43322291
23	protein neddylation (GO:0045116)	3.41687344
24	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.23755952
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22329471
26	NADH dehydrogenase complex assembly (GO:0010257)	3.22329471
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22329471
28	respiratory electron transport chain (GO:0022904)	3.22269956
29	electron transport chain (GO:0022900)	3.21141442
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.20914595
31	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.11561697
32	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.10071901
33	platelet dense granule organization (GO:0060155)	3.06924172
34	GPI anchor metabolic process (GO:0006505)	3.06386277
35	GPI anchor biosynthetic process (GO:0006506)	3.05210700
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.03313727
37	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.00257258
38	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.97927540
39	maturation of SSU-rRNA (GO:0030490)	2.96638625
40	response to pheromone (GO:0019236)	2.93754940
41	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90153396
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.87803312
43	mannosylation (GO:0097502)	2.87588326
44	viral life cycle (GO:0019058)	2.86835887
45	behavioral response to nicotine (GO:0035095)	2.86341780
46	translational initiation (GO:0006413)	2.85319942
47	cellular protein complex disassembly (GO:0043624)	2.85011125
48	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.78760589
49	translation (GO:0006412)	2.77098047
50	base-excision repair, AP site formation (GO:0006285)	2.76580059
51	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.74822375
52	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.73147779
53	purine deoxyribonucleotide catabolic process (GO:0009155)	2.72463078
54	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.69978222
55	indole-containing compound catabolic process (GO:0042436)	2.65545928
56	indolalkylamine catabolic process (GO:0046218)	2.65545928
57	tryptophan catabolic process (GO:0006569)	2.65545928
58	deoxyribose phosphate catabolic process (GO:0046386)	2.65200057
59	actin nucleation (GO:0045010)	2.64208015
60	positive regulation of interleukin-17 production (GO:0032740)	2.64152151
61	deoxyribonucleotide catabolic process (GO:0009264)	2.62737467
62	axoneme assembly (GO:0035082)	2.59536732
63	mast cell activation (GO:0045576)	2.59207983
64	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.59123340
65	water-soluble vitamin biosynthetic process (GO:0042364)	2.57511057
66	chaperone-mediated protein transport (GO:0072321)	2.56196292
67	respiratory chain complex IV assembly (GO:0008535)	2.54795627
68	piRNA metabolic process (GO:0034587)	2.53315245
69	proteasome assembly (GO:0043248)	2.52910151
70	cytochrome complex assembly (GO:0017004)	2.51542048
71	negative regulation of mast cell activation (GO:0033004)	2.51178643
72	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.49180282
73	iron-sulfur cluster assembly (GO:0016226)	2.48735394
74	metallo-sulfur cluster assembly (GO:0031163)	2.48735394
75	aggressive behavior (GO:0002118)	2.48434253
76	positive regulation of B cell differentiation (GO:0045579)	2.48363430
77	termination of RNA polymerase III transcription (GO:0006386)	2.47209131
78	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.47209131
79	hydrogen ion transmembrane transport (GO:1902600)	2.46488156
80	detection of light stimulus involved in sensory perception (GO:0050962)	2.45535294
81	detection of light stimulus involved in visual perception (GO:0050908)	2.45535294
82	indolalkylamine metabolic process (GO:0006586)	2.44892645
83	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.43943079
84	regulation of regulatory T cell differentiation (GO:0045589)	2.43504450
85	positive regulation of defense response to virus by host (GO:0002230)	2.43369658
86	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.42519162
87	purine nucleotide salvage (GO:0032261)	2.42322150
88	proton transport (GO:0015992)	2.42271894
89	kynurenine metabolic process (GO:0070189)	2.42214309
90	regulation of B cell receptor signaling pathway (GO:0050855)	2.42110823
91	GTP biosynthetic process (GO:0006183)	2.41930554
92	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.41883312
93	ribosomal small subunit biogenesis (GO:0042274)	2.41850790
94	negative regulation of telomere maintenance (GO:0032205)	2.41371690
95	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.40797449
96	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.40738329
97	hydrogen transport (GO:0006818)	2.40542672
98	ATP biosynthetic process (GO:0006754)	2.40439626
99	response to interferon-beta (GO:0035456)	2.40097820
100	regulation of alpha-beta T cell proliferation (GO:0046640)	2.38137239

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.26514184
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.23926230
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.15728192
4	VDR_22108803_ChIP-Seq_LS180_Human	3.14265990
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81037488
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.72440274
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.62133029
8	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.59711890
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.59349004
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.54151306
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52987507
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.49171856
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27337533
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.26760276
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.17905378
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.09629865
17	EZH2_22144423_ChIP-Seq_EOC_Human	1.87978318
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.87702891
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.82135762
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.80429663
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.79745117
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.79319889
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77615256
24	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.75274570
25	EWS_26573619_Chip-Seq_HEK293_Human	1.74653968
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73262556
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71183944
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.69894728
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69544873
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.63329429
31	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.62689946
32	FUS_26573619_Chip-Seq_HEK293_Human	1.60335758
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.57102303
34	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53746980
35	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52503472
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52503472
37	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.50689164
38	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.48851201
39	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.46819957
40	AR_20517297_ChIP-Seq_VCAP_Human	1.46070689
41	GATA3_26560356_Chip-Seq_TH2_Human	1.43048192
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.40189645
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.39681769
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38999906
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38043992
46	P300_19829295_ChIP-Seq_ESCs_Human	1.37920651
47	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.35336762
48	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.33950743
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32052944
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32052944
51	MYB_26560356_Chip-Seq_TH2_Human	1.30330161
52	NCOR_22424771_ChIP-Seq_293T_Human	1.30307561
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28890685
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27545928
55	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27151104
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.26015070
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26015070
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25803983
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23653801
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23063684
61	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.23018638
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23018274
63	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.22665123
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21050789
65	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20992534
66	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20866227
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18972633
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17061289
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15474336
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15198749
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14968143
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13994578
73	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11887552
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.11848717
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10993935
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10647916
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10335113
78	GATA3_27048872_Chip-Seq_THYMUS_Human	1.10129588
79	GBX2_23144817_ChIP-Seq_PC3_Human	1.09522190
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09163605
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08870266
82	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08443632
83	BCAT_22108803_ChIP-Seq_LS180_Human	1.06423646
84	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05094717
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04011368
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02141041
87	RUNX_20019798_ChIP-Seq_JUKART_Human	0.99394927
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98491824
89	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.98332546
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.98272411
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.96897275
92	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96666840
93	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.96122617
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94777637
95	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94629204
96	SCL_19346495_ChIP-Seq_HPC-7_Human	0.94568865
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94027453
98	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.93949619
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92520735
100	TCF4_22108803_ChIP-Seq_LS180_Human	0.92336756

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.61014411
2	MP0009379_abnormal_foot_pigmentation	3.37091442
3	MP0001835_abnormal_antigen_presentation	3.16613947
4	MP0006292_abnormal_olfactory_placode	2.87334119
5	MP0002837_dystrophic_cardiac_calcinosis	2.40679361
6	MP0002102_abnormal_ear_morphology	2.13118132
7	MP0005645_abnormal_hypothalamus_physiol	2.10468936
8	MP0008877_abnormal_DNA_methylation	2.07162975
9	MP0006072_abnormal_retinal_apoptosis	2.04696413
10	MP0009785_altered_susceptibility_to	2.00438534
11	MP0004147_increased_porphyrin_level	1.99441780
12	MP0008872_abnormal_physiological_respon	1.93487561
13	MP0003806_abnormal_nucleotide_metabolis	1.92121713
14	MP0005646_abnormal_pituitary_gland	1.88270320
15	MP0005075_abnormal_melanosome_morpholog	1.85709955
16	MP0002148_abnormal_hypersensitivity_rea	1.84050036
17	MP0001800_abnormal_humoral_immune	1.76799579
18	MP0001873_stomach_inflammation	1.76096969
19	MP0005084_abnormal_gallbladder_morpholo	1.73243087
20	MP0005551_abnormal_eye_electrophysiolog	1.71103955
21	MP0002166_altered_tumor_susceptibility	1.69929468
22	MP0000372_irregular_coat_pigmentation	1.64999301
23	MP0005000_abnormal_immune_tolerance	1.64686544
24	MP0003646_muscle_fatigue	1.60328265
25	MP0003763_abnormal_thymus_physiology	1.58565703
26	MP0002138_abnormal_hepatobiliary_system	1.57274421
27	MP0004145_abnormal_muscle_electrophysio	1.55803501
28	MP0008875_abnormal_xenobiotic_pharmacok	1.52219980
29	MP0009333_abnormal_splenocyte_physiolog	1.50691426
30	MP0008995_early_reproductive_senescence	1.50535206
31	MP0003787_abnormal_imprinting	1.50388333
32	MP0001968_abnormal_touch/_nociception	1.49288806
33	MP0001986_abnormal_taste_sensitivity	1.49260398
34	MP0002876_abnormal_thyroid_physiology	1.48979680
35	MP0002163_abnormal_gland_morphology	1.48657678
36	MP0004142_abnormal_muscle_tone	1.46630299
37	MP0002723_abnormal_immune_serum	1.43639112
38	MP0002006_tumorigenesis	1.43141897
39	MP0005387_immune_system_phenotype	1.42243926
40	MP0001790_abnormal_immune_system	1.42243926
41	MP0000685_abnormal_immune_system	1.35031375
42	MP0005389_reproductive_system_phenotype	1.34235521
43	MP0002452_abnormal_antigen_presenting	1.33981408
44	MP0002420_abnormal_adaptive_immunity	1.33053931
45	MP0003195_calcinosis	1.32122919
46	MP0001819_abnormal_immune_cell	1.31850568
47	MP0004885_abnormal_endolymph	1.31219192
48	MP0002160_abnormal_reproductive_system	1.29409219
49	MP0001905_abnormal_dopamine_level	1.29375861
50	MP0005025_abnormal_response_to	1.19924981
51	MP0005253_abnormal_eye_physiology	1.19383313
52	MP0009764_decreased_sensitivity_to	1.16435348
53	MP0001764_abnormal_homeostasis	1.13508914
54	MP0003252_abnormal_bile_duct	1.11082109
55	MP0006036_abnormal_mitochondrial_physio	1.10896338
56	MP0002736_abnormal_nociception_after	1.08585152
57	MP0001919_abnormal_reproductive_system	1.06084629
58	MP0002234_abnormal_pharynx_morphology	1.05104640
59	MP0005410_abnormal_fertilization	1.04699261
60	MP0002095_abnormal_skin_pigmentation	1.04114974
61	MP0006276_abnormal_autonomic_nervous	1.04078768
62	MP0003866_abnormal_defecation	1.03992487
63	MP0003880_abnormal_central_pattern	1.02986805
64	MP0005174_abnormal_tail_pigmentation	1.02767673
65	MP0002398_abnormal_bone_marrow	1.02607728
66	MP0003724_increased_susceptibility_to	1.02314588
67	MP0000716_abnormal_immune_system	1.01975707
68	MP0005379_endocrine/exocrine_gland_phen	1.01596881
69	MP0008058_abnormal_DNA_repair	1.01492565
70	MP0000465_gastrointestinal_hemorrhage	0.95773879
71	MP0000689_abnormal_spleen_morphology	0.94571110
72	MP0005636_abnormal_mineral_homeostasis	0.94162125
73	MP0003011_delayed_dark_adaptation	0.93888229
74	MP0008789_abnormal_olfactory_epithelium	0.93499189
75	MP0005360_urolithiasis	0.91536027
76	MP0002653_abnormal_ependyma_morphology	0.91421929
77	MP0003786_premature_aging	0.89093296
78	MP0002272_abnormal_nervous_system	0.88212727
79	MP0001765_abnormal_ion_homeostasis	0.88004992
80	MP0001845_abnormal_inflammatory_respons	0.87393272
81	MP0001485_abnormal_pinna_reflex	0.87139771
82	MP0006082_CNS_inflammation	0.85861636
83	MP0002735_abnormal_chemical_nociception	0.85571846
84	MP0000631_abnormal_neuroendocrine_gland	0.85123546
85	MP0010155_abnormal_intestine_physiology	0.84318135
86	MP0001501_abnormal_sleep_pattern	0.84236694
87	MP0002405_respiratory_system_inflammati	0.83937092
88	MP0003186_abnormal_redox_activity	0.83775298
89	MP0005377_hearing/vestibular/ear_phenot	0.83391474
90	MP0003878_abnormal_ear_physiology	0.83391474
91	MP0002638_abnormal_pupillary_reflex	0.81743015
92	MP0002693_abnormal_pancreas_physiology	0.81276636
93	MP0008469_abnormal_protein_level	0.78543036
94	MP0002822_catalepsy	0.76279453
95	MP0002429_abnormal_blood_cell	0.76095960
96	MP0009745_abnormal_behavioral_response	0.75952855
97	MP0003567_abnormal_fetal_cardiomyocyte	0.74051561
98	MP0009643_abnormal_urine_homeostasis	0.73664330
99	MP0001970_abnormal_pain_threshold	0.73613362
100	MP0002419_abnormal_innate_immunity	0.73102352

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.79806584
2	Congenital stationary night blindness (HP:0007642)	3.76316346
3	Acute necrotizing encephalopathy (HP:0006965)	3.74295383
4	Mitochondrial inheritance (HP:0001427)	3.69770546
5	Hepatocellular necrosis (HP:0001404)	3.38458445
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.35463685
7	Increased CSF lactate (HP:0002490)	3.31221769
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.27795549
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.27231621
10	Acute encephalopathy (HP:0006846)	3.19535439
11	Progressive macrocephaly (HP:0004481)	3.17846099
12	Aplastic anemia (HP:0001915)	3.17074769
13	Abolished electroretinogram (ERG) (HP:0000550)	3.13043554
14	Hepatic necrosis (HP:0002605)	3.11303001
15	IgG deficiency (HP:0004315)	3.09673561
16	3-Methylglutaconic aciduria (HP:0003535)	3.06718176
17	Severe combined immunodeficiency (HP:0004430)	3.06413827
18	Pancreatic cysts (HP:0001737)	3.01363016
19	Abnormality of the prostate (HP:0008775)	2.94851522
20	Increased hepatocellular lipid droplets (HP:0006565)	2.91442224
21	Abnormality of B cell number (HP:0010975)	2.88616002
22	Hypoproteinemia (HP:0003075)	2.87320128
23	Attenuation of retinal blood vessels (HP:0007843)	2.83314898
24	Molar tooth sign on MRI (HP:0002419)	2.82926383
25	Abnormality of midbrain morphology (HP:0002418)	2.82926383
26	Lipid accumulation in hepatocytes (HP:0006561)	2.77337872
27	Thyroiditis (HP:0100646)	2.75537422
28	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.74458984
29	Constricted visual fields (HP:0001133)	2.72797761
30	Renal Fanconi syndrome (HP:0001994)	2.71828898
31	True hermaphroditism (HP:0010459)	2.68586347
32	Pancreatic fibrosis (HP:0100732)	2.66014592
33	Optic disc pallor (HP:0000543)	2.62954480
34	B lymphocytopenia (HP:0010976)	2.62931344
35	Cerebral edema (HP:0002181)	2.59994062
36	Reticulocytopenia (HP:0001896)	2.54152896
37	Panhypogammaglobulinemia (HP:0003139)	2.53285340
38	Decreased central vision (HP:0007663)	2.52491663
39	Congenital, generalized hypertrichosis (HP:0004540)	2.50441614
40	Abnormality of cells of the erythroid lineage (HP:0012130)	2.48850832
41	Renal cortical cysts (HP:0000803)	2.48255052
42	Increased intramyocellular lipid droplets (HP:0012240)	2.47809786
43	Stomatitis (HP:0010280)	2.45014581
44	Methylmalonic acidemia (HP:0002912)	2.43649074
45	Nephronophthisis (HP:0000090)	2.36172823
46	Abnormality of the renal cortex (HP:0011035)	2.34939189
47	Increased serum lactate (HP:0002151)	2.30916341
48	Generalized aminoaciduria (HP:0002909)	2.27408428
49	Exertional dyspnea (HP:0002875)	2.26993009
50	Stenosis of the external auditory canal (HP:0000402)	2.23692772
51	Combined immunodeficiency (HP:0005387)	2.22566889
52	Abnormality of T cell number (HP:0011839)	2.21879391
53	T lymphocytopenia (HP:0005403)	2.20988842
54	Abnormal number of erythroid precursors (HP:0012131)	2.20614212
55	Type 2 muscle fiber atrophy (HP:0003554)	2.18628549
56	Lactic acidosis (HP:0003128)	2.14379444
57	Medial flaring of the eyebrow (HP:0010747)	2.11486423
58	Macrocytic anemia (HP:0001972)	2.10943337
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08710978
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08710978
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07710461
62	Increased muscle lipid content (HP:0009058)	2.07039256
63	Pendular nystagmus (HP:0012043)	2.05059002
64	Abnormality of T cells (HP:0002843)	2.01956302
65	Lethargy (HP:0001254)	2.01428710
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.01375045
67	Abnormality of alanine metabolism (HP:0010916)	2.01375045
68	Hyperalaninemia (HP:0003348)	2.01375045
69	Absent/shortened dynein arms (HP:0200106)	2.01280428
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01280428
71	Abnormality of urine glucose concentration (HP:0011016)	1.98264578
72	Glycosuria (HP:0003076)	1.98264578
73	Abnormality of eosinophils (HP:0001879)	1.97152964
74	Agammaglobulinemia (HP:0004432)	1.97128006
75	Abnormality of the renal medulla (HP:0100957)	1.97084045
76	Asplenia (HP:0001746)	1.96201433
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.94387040
78	Absent thumb (HP:0009777)	1.94382193
79	Hyperglycinemia (HP:0002154)	1.92764711
80	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.88759934
81	Pallor (HP:0000980)	1.88437689
82	Autoimmune hemolytic anemia (HP:0001890)	1.87941347
83	Increased IgM level (HP:0003496)	1.86816050
84	Methylmalonic aciduria (HP:0012120)	1.86078379
85	Abnormal drinking behavior (HP:0030082)	1.85103854
86	Polydipsia (HP:0001959)	1.85103854
87	Abnormality of DNA repair (HP:0003254)	1.84841381
88	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.82046496
89	Pancytopenia (HP:0001876)	1.81626737
90	Respiratory failure (HP:0002878)	1.80149703
91	Abnormality of renal resorption (HP:0011038)	1.80088037
92	Keratoconus (HP:0000563)	1.79901241
93	Increased corneal curvature (HP:0100692)	1.79901241
94	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.78470227
95	Dicarboxylic aciduria (HP:0003215)	1.78470227
96	Abnormality of male internal genitalia (HP:0000022)	1.75299111
97	Sclerocornea (HP:0000647)	1.75248129
98	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.74552135
99	Ketosis (HP:0001946)	1.73266676
100	Abnormality of macular pigmentation (HP:0008002)	1.72906798

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.60798591
2	CDK19	3.12869234
3	MAP4K2	3.03377501
4	BCKDK	2.98382138
5	TAOK3	2.61278313
6	VRK2	2.47643747
7	FRK	2.46383694
8	ADRBK2	2.43561045
9	GRK1	2.42494370
10	KDR	2.40933713
11	NUAK1	2.34148127
12	ZAK	2.18456881
13	TLK1	2.15227862
14	KIT	1.90787730
15	TEC	1.72551708
16	EIF2AK3	1.67222627
17	MAP4K1	1.64479075
18	MAP3K12	1.60230602
19	TESK2	1.58337794
20	WNK4	1.53438709
21	PINK1	1.49685107
22	SCYL2	1.48304665
23	ITK	1.45495993
24	VRK1	1.43903029
25	SYK	1.41194240
26	BMPR2	1.38157748
27	TIE1	1.34698887
28	STK16	1.31846140
29	FES	1.31659977
30	FLT3	1.31522679
31	BMPR1B	1.31328996
32	OXSR1	1.29620028
33	INSRR	1.26360881
34	MUSK	1.22893696
35	IKBKB	1.16425908
36	PASK	1.12776231
37	WNK3	1.03501995
38	TNK2	1.00616684
39	BTK	0.99890921
40	CSF1R	0.98118675
41	MST4	0.97913376
42	IKBKE	0.92318579
43	PIK3CG	0.91979061
44	STK39	0.91925638
45	MAPKAPK5	0.89381483
46	DAPK1	0.88402816
47	LYN	0.87292083
48	MYLK	0.86670186
49	PRKCQ	0.85656305
50	DYRK2	0.85392431
51	GRK6	0.84703838
52	LCK	0.84051079
53	DAPK2	0.79335222
54	ERBB3	0.75817829
55	TAF1	0.72156382
56	CSNK1G3	0.67877758
57	MAPK13	0.66374926
58	MAP2K6	0.66312193
59	ADRBK1	0.65424143
60	RPS6KA5	0.63955992
61	OBSCN	0.63830604
62	TRPM7	0.63309852
63	CAMKK2	0.63187254
64	DAPK3	0.61371671
65	CSNK1G1	0.60998878
66	GRK7	0.60021748
67	MATK	0.59598033
68	PRKCE	0.58503432
69	EIF2AK2	0.56674291
70	LIMK1	0.56473035
71	RPS6KA4	0.56252547
72	JAK3	0.55870015
73	CSNK1G2	0.55513027
74	IGF1R	0.52623558
75	CCNB1	0.52008072
76	TRIM28	0.50721393
77	PIM1	0.50283307
78	PRKACA	0.49595271
79	CDK8	0.49223069
80	GRK5	0.47838397
81	PRKCA	0.45401864
82	MKNK1	0.43672523
83	PIM2	0.43162507
84	PHKG2	0.41955768
85	PHKG1	0.41955768
86	CSNK2A2	0.40466982
87	PRKCD	0.39775914
88	ILK	0.39695646
89	CSNK2A1	0.39607752
90	RPS6KB2	0.38323099
91	ABL1	0.38237116
92	TBK1	0.37721275
93	PIK3CA	0.36476265
94	PRKCG	0.34113215
95	CSNK1A1L	0.34108486
96	ATR	0.33645616
97	RPS6KA6	0.32923721
98	MAP3K11	0.32847040
99	CSNK1A1	0.32402070
100	CAMK2A	0.32185527

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.69811677
2	Ribosome_Homo sapiens_hsa03010	3.44291553
3	Allograft rejection_Homo sapiens_hsa05330	3.18072387
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.12728347
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.98313656
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.98178072
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.90126717
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.75755105
9	Proteasome_Homo sapiens_hsa03050	2.72406332
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.72087598
11	Parkinsons disease_Homo sapiens_hsa05012	2.55279830
12	Protein export_Homo sapiens_hsa03060	2.28153160
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.14229484
14	Antigen processing and presentation_Homo sapiens_hsa04612	2.00317679
15	Phototransduction_Homo sapiens_hsa04744	1.82783254
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.70095186
17	RNA polymerase_Homo sapiens_hsa03020	1.69613870
18	Alzheimers disease_Homo sapiens_hsa05010	1.63083397
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.60632870
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57800127
21	Homologous recombination_Homo sapiens_hsa03440	1.52733184
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.49562526
23	Huntingtons disease_Homo sapiens_hsa05016	1.48706123
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.40223161
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39929878
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.36594808
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.36466183
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34522706
29	RNA degradation_Homo sapiens_hsa03018	1.30476448
30	Propanoate metabolism_Homo sapiens_hsa00640	1.14181494
31	Viral myocarditis_Homo sapiens_hsa05416	1.11089773
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09344047
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05627589
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03566187
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02275731
36	Butanoate metabolism_Homo sapiens_hsa00650	1.01416162
37	Olfactory transduction_Homo sapiens_hsa04740	0.99737806
38	One carbon pool by folate_Homo sapiens_hsa00670	0.99153044
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97280086
40	Nitrogen metabolism_Homo sapiens_hsa00910	0.96310627
41	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.94182380
42	Peroxisome_Homo sapiens_hsa04146	0.93559739
43	Basal transcription factors_Homo sapiens_hsa03022	0.93394282
44	Caffeine metabolism_Homo sapiens_hsa00232	0.92447873
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90962078
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.89339772
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88154607
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.86596372
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86036028
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84057744
51	Retinol metabolism_Homo sapiens_hsa00830	0.82129683
52	Regulation of autophagy_Homo sapiens_hsa04140	0.80775263
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79013683
54	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.78126531
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.77133239
56	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76760763
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76511067
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76263425
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73005485
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71119895
61	Purine metabolism_Homo sapiens_hsa00230	0.70487041
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69914424
63	Leishmaniasis_Homo sapiens_hsa05140	0.66253183
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66168584
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.64371657
66	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61100548
67	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.60104564
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59765627
69	Taste transduction_Homo sapiens_hsa04742	0.59657619
70	Mismatch repair_Homo sapiens_hsa03430	0.59019825
71	Base excision repair_Homo sapiens_hsa03410	0.58126542
72	Sulfur metabolism_Homo sapiens_hsa00920	0.57329304
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.52828959
74	Spliceosome_Homo sapiens_hsa03040	0.50775908
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.50286325
76	Selenocompound metabolism_Homo sapiens_hsa00450	0.49990232
77	Metabolic pathways_Homo sapiens_hsa01100	0.49466007
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49263210
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49129712
80	Nicotine addiction_Homo sapiens_hsa05033	0.48810827
81	RNA transport_Homo sapiens_hsa03013	0.47861933
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46244018
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.44222320
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43671435
85	Fatty acid elongation_Homo sapiens_hsa00062	0.42762084
86	Salivary secretion_Homo sapiens_hsa04970	0.41147431
87	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40772180
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.40081062
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40010810
90	Herpes simplex infection_Homo sapiens_hsa05168	0.39901363
91	DNA replication_Homo sapiens_hsa03030	0.38765030
92	African trypanosomiasis_Homo sapiens_hsa05143	0.35861504
93	Non-homologous end-joining_Homo sapiens_hsa03450	0.35837324
94	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.34707534
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33538901
96	Morphine addiction_Homo sapiens_hsa05032	0.33078477
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.30992358
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30101834
99	Serotonergic synapse_Homo sapiens_hsa04726	0.28226922
100	Malaria_Homo sapiens_hsa05144	0.26431017

RPS3AP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »