ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gonadal mesoderm development (GO:0007506)	7.46468432
2	DNA deamination (GO:0045006)	7.02770219
3	sphingosine metabolic process (GO:0006670)	5.47090107
4	sphingoid metabolic process (GO:0046519)	5.00235603
5	diol metabolic process (GO:0034311)	4.98315276
6	neuronal action potential propagation (GO:0019227)	4.55356257
7	base-excision repair, AP site formation (GO:0006285)	4.45123670
8	protein neddylation (GO:0045116)	4.25180063
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.15473604
10	negative regulation of telomere maintenance (GO:0032205)	4.13292229
11	L-fucose catabolic process (GO:0042355)	3.87682037
12	fucose catabolic process (GO:0019317)	3.87682037
13	L-fucose metabolic process (GO:0042354)	3.87682037
14	DNA methylation involved in gamete generation (GO:0043046)	3.85408791
15	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.84514329
16	piRNA metabolic process (GO:0034587)	3.60804703
17	organelle disassembly (GO:1903008)	3.59285195
18	regulation of meiosis I (GO:0060631)	3.55027753
19	ribonucleoprotein complex disassembly (GO:0032988)	3.53912348
20	mannosylation (GO:0097502)	3.53906863
21	indolalkylamine metabolic process (GO:0006586)	3.43963031
22	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.43565990
23	ATP synthesis coupled proton transport (GO:0015986)	3.39931743
24	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.39931743
25	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.32523138
26	phosphate ion homeostasis (GO:0055062)	3.30237560
27	trivalent inorganic anion homeostasis (GO:0072506)	3.30237560
28	kynurenine metabolic process (GO:0070189)	3.29898004
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.28853360
30	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.22797066
31	negative regulation of mast cell activation (GO:0033004)	3.21784755
32	positive regulation of antigen processing and presentation (GO:0002579)	3.21488472
33	ubiquinone biosynthetic process (GO:0006744)	3.18453487
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.17701195
35	rRNA catabolic process (GO:0016075)	3.16786743
36	RNA phosphodiester bond hydrolysis (GO:0090501)	3.13560264
37	rhodopsin mediated signaling pathway (GO:0016056)	3.12040139
38	behavioral response to nicotine (GO:0035095)	3.08165523
39	tryptophan catabolic process (GO:0006569)	3.07936671
40	indole-containing compound catabolic process (GO:0042436)	3.07936671
41	indolalkylamine catabolic process (GO:0046218)	3.07936671
42	respiratory electron transport chain (GO:0022904)	3.04855220
43	electron transport chain (GO:0022900)	3.04699360
44	immunoglobulin mediated immune response (GO:0016064)	3.02829684
45	auditory receptor cell stereocilium organization (GO:0060088)	3.01436561
46	tyrosine phosphorylation of STAT protein (GO:0007260)	2.99470463
47	sulfate transmembrane transport (GO:1902358)	2.99091955
48	one-carbon compound transport (GO:0019755)	2.96896301
49	ribosomal small subunit assembly (GO:0000028)	2.92049891
50	positive regulation of meiosis (GO:0045836)	2.90531051
51	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.88184112
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.88184112
53	lipopolysaccharide biosynthetic process (GO:0009103)	2.87300180
54	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.86282156
55	protein-chromophore linkage (GO:0018298)	2.85669562
56	purine deoxyribonucleotide catabolic process (GO:0009155)	2.84466001
57	norepinephrine metabolic process (GO:0042415)	2.83007368
58	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.81309448
59	cullin deneddylation (GO:0010388)	2.80788038
60	maturation of 5.8S rRNA (GO:0000460)	2.80009130
61	DNA modification (GO:0006304)	2.75275371
62	left/right axis specification (GO:0070986)	2.73445991
63	response to epinephrine (GO:0071871)	2.71489680
64	platelet dense granule organization (GO:0060155)	2.71129347
65	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.71026620
66	termination of RNA polymerase III transcription (GO:0006386)	2.71026620
67	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.70369305
68	amine catabolic process (GO:0009310)	2.70049468
69	cellular biogenic amine catabolic process (GO:0042402)	2.70049468
70	positive regulation of meiotic cell cycle (GO:0051446)	2.68690051
71	mast cell degranulation (GO:0043303)	2.68482494
72	mast cell activation involved in immune response (GO:0002279)	2.68482494
73	water-soluble vitamin biosynthetic process (GO:0042364)	2.67675004
74	maturation of SSU-rRNA (GO:0030490)	2.66805935
75	ubiquinone metabolic process (GO:0006743)	2.66516848
76	cytidine metabolic process (GO:0046087)	2.65909828
77	cytidine catabolic process (GO:0006216)	2.65909828
78	cytidine deamination (GO:0009972)	2.65909828
79	lipopolysaccharide metabolic process (GO:0008653)	2.63301844
80	aromatic amino acid family catabolic process (GO:0009074)	2.61651107
81	tryptophan metabolic process (GO:0006568)	2.60990976
82	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.60444339
83	neural tube formation (GO:0001841)	2.60264704
84	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.59478553
85	glycerol metabolic process (GO:0006071)	2.58956159
86	heart contraction (GO:0060047)	2.58409757
87	heart process (GO:0003015)	2.58409757
88	growth hormone receptor signaling pathway (GO:0060396)	2.57582013
89	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	2.57525940
90	sulfate transport (GO:0008272)	2.57414468
91	hydrogen ion transmembrane transport (GO:1902600)	2.57250508
92	centriole replication (GO:0007099)	2.56625043
93	quinone biosynthetic process (GO:1901663)	2.56501600
94	glutathione biosynthetic process (GO:0006750)	2.55490784
95	DNA dealkylation (GO:0035510)	2.55440708
96	hydrogen transport (GO:0006818)	2.55416352
97	translational termination (GO:0006415)	2.54758255
98	sulfation (GO:0051923)	2.54449131
99	regulation of antigen processing and presentation (GO:0002577)	2.54273171
100	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.52843370

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.61913040
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.10341345
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.10111551
4	VDR_22108803_ChIP-Seq_LS180_Human	2.46641254
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46018093
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.42753655
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.39830704
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.30662029
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.21133616
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.21084273
11	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.00971388
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.95942625
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.92281172
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.89968864
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.77993471
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.77361500
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71969529
18	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.71054516
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.65871737
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.64314544
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.60587015
22	STAT1_20625510_ChIP-Seq_HELA_Human	1.57753337
23	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.57717183
24	SOX2_19829295_ChIP-Seq_ESCs_Human	1.54421801
25	NANOG_19829295_ChIP-Seq_ESCs_Human	1.54421801
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53316721
27	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.50863480
28	TAF2_19829295_ChIP-Seq_ESCs_Human	1.47768444
29	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.46866951
30	P300_19829295_ChIP-Seq_ESCs_Human	1.45828798
31	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.43211013
32	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.40251582
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40022172
34	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.39502788
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39021105
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.36356414
37	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.35347983
38	AR_20517297_ChIP-Seq_VCAP_Human	1.35148901
39	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.33475008
40	GATA3_26560356_Chip-Seq_TH2_Human	1.32574986
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31319181
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31319181
43	FUS_26573619_Chip-Seq_HEK293_Human	1.31216439
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.31036227
45	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.29897128
46	VDR_23849224_ChIP-Seq_CD4+_Human	1.29104971
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.28980833
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27995063
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27000903
50	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26122385
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.23495556
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22835349
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.22397692
54	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.21682948
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21486675
56	ERA_21632823_ChIP-Seq_H3396_Human	1.21025412
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20830899
58	HOXB7_26014856_ChIP-Seq_BT474_Human	1.20822172
59	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20313431
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18949318
61	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18438760
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.18129126
63	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17635812
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17635812
65	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.17515725
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.17486245
67	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.17083800
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.16351161
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.12769594
70	NCOR_22424771_ChIP-Seq_293T_Human	1.12744923
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12577525
72	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12051155
73	RAC3_21632823_ChIP-Seq_H3396_Human	1.11082295
74	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.11072277
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.08317193
76	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.07532869
77	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.07321406
78	P53_21459846_ChIP-Seq_SAOS-2_Human	1.06392349
79	ELK1_19687146_ChIP-ChIP_HELA_Human	1.06373967
80	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05404409
81	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.04205212
82	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03995975
83	FOXP3_21729870_ChIP-Seq_TREG_Human	1.02565874
84	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02480511
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02300207
86	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00661596
87	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.98344494
88	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97594879
89	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.97346972
90	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97044338
91	BCL6_27268052_Chip-Seq_Bcells_Human	0.96707473
92	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95974619
93	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95823308
94	TCF4_23295773_ChIP-Seq_U87_Human	0.95741393
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95532343
96	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95178250
97	EWS_26573619_Chip-Seq_HEK293_Human	0.95174057
98	CEBPB_22108803_ChIP-Seq_LS180_Human	0.94611149
99	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.92882851
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.92746648

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	5.93796847
2	MP0002837_dystrophic_cardiac_calcinosis	5.67544574
3	MP0003806_abnormal_nucleotide_metabolis	4.36408118
4	MP0003646_muscle_fatigue	3.41335581
5	MP0005171_absent_coat_pigmentation	2.79947638
6	MP0004145_abnormal_muscle_electrophysio	2.79768955
7	MP0003195_calcinosis	2.65616934
8	MP0005085_abnormal_gallbladder_physiolo	2.60708039
9	MP0001835_abnormal_antigen_presentation	2.49412870
10	MP0003136_yellow_coat_color	2.47518225
11	MP0003787_abnormal_imprinting	2.46796994
12	MP0002822_catalepsy	2.45925035
13	MP0005075_abnormal_melanosome_morpholog	2.42845748
14	MP0003045_fibrosis	2.40020651
15	MP0006072_abnormal_retinal_apoptosis	2.16673772
16	MP0002653_abnormal_ependyma_morphology	2.08889470
17	MP0003252_abnormal_bile_duct	2.04369446
18	MP0009379_abnormal_foot_pigmentation	2.03699949
19	MP0008877_abnormal_DNA_methylation	1.94859835
20	MP0004147_increased_porphyrin_level	1.87810215
21	MP0001968_abnormal_touch/_nociception	1.85460136
22	MP0000569_abnormal_digit_pigmentation	1.81956843
23	MP0000372_irregular_coat_pigmentation	1.66826114
24	MP0004142_abnormal_muscle_tone	1.61656207
25	MP0002095_abnormal_skin_pigmentation	1.58895119
26	MP0005671_abnormal_response_to	1.57619489
27	MP0005174_abnormal_tail_pigmentation	1.55585273
28	MP0009764_decreased_sensitivity_to	1.52104413
29	MP0003879_abnormal_hair_cell	1.45535833
30	MP0009046_muscle_twitch	1.44823986
31	MP0008872_abnormal_physiological_respon	1.42773121
32	MP0001501_abnormal_sleep_pattern	1.41215754
33	MP0005551_abnormal_eye_electrophysiolog	1.39899596
34	MP0002735_abnormal_chemical_nociception	1.35276460
35	MP0005253_abnormal_eye_physiology	1.34195293
36	MP0009745_abnormal_behavioral_response	1.33565456
37	MP0006054_spinal_hemorrhage	1.33216623
38	MP0001905_abnormal_dopamine_level	1.28804200
39	MP0001970_abnormal_pain_threshold	1.28053567
40	MP0003880_abnormal_central_pattern	1.25310072
41	MP0006036_abnormal_mitochondrial_physio	1.23528708
42	MP0002272_abnormal_nervous_system	1.22876384
43	MP0002102_abnormal_ear_morphology	1.19102524
44	MP0002733_abnormal_thermal_nociception	1.16835199
45	MP0006276_abnormal_autonomic_nervous	1.14250603
46	MP0005670_abnormal_white_adipose	1.14129703
47	MP0002638_abnormal_pupillary_reflex	1.13093334
48	MP0001986_abnormal_taste_sensitivity	1.12898074
49	MP0003121_genomic_imprinting	1.10266838
50	MP0008995_early_reproductive_senescence	1.10091166
51	MP0002938_white_spotting	1.09922461
52	MP0001984_abnormal_olfaction	1.04827657
53	MP0004043_abnormal_pH_regulation	1.03702740
54	MP0004381_abnormal_hair_follicle	1.02476418
55	MP0002928_abnormal_bile_duct	1.02252318
56	MP0002736_abnormal_nociception_after	1.01732995
57	MP0000015_abnormal_ear_pigmentation	1.01075088
58	MP0001486_abnormal_startle_reflex	0.97038397
59	MP0005410_abnormal_fertilization	0.94974002
60	MP0002734_abnormal_mechanical_nocicepti	0.92850174
61	MP0003137_abnormal_impulse_conducting	0.92656861
62	MP0002396_abnormal_hematopoietic_system	0.92182741
63	MP0001800_abnormal_humoral_immune	0.88965845
64	MP0002148_abnormal_hypersensitivity_rea	0.88358487
65	MP0003890_abnormal_embryonic-extraembry	0.87820430
66	MP0008789_abnormal_olfactory_epithelium	0.86945912
67	MP0004742_abnormal_vestibular_system	0.86184811
68	MP0000230_abnormal_systemic_arterial	0.86170779
69	MP0005646_abnormal_pituitary_gland	0.85028064
70	MP0002572_abnormal_emotion/affect_behav	0.79557401
71	MP0005365_abnormal_bile_salt	0.77394492
72	MP0009765_abnormal_xenobiotic_induced	0.77322022
73	MP0001790_abnormal_immune_system	0.76631374
74	MP0005387_immune_system_phenotype	0.76631374
75	MP0010386_abnormal_urinary_bladder	0.76002123
76	MP0002452_abnormal_antigen_presenting	0.74885343
77	MP0001529_abnormal_vocalization	0.74742797
78	MP0005084_abnormal_gallbladder_morpholo	0.73792073
79	MP0002075_abnormal_coat/hair_pigmentati	0.72397417
80	MP0004885_abnormal_endolymph	0.72316696
81	MP0006035_abnormal_mitochondrial_morpho	0.69963136
82	MP0001440_abnormal_grooming_behavior	0.67891999
83	MP0003011_delayed_dark_adaptation	0.67376179
84	MP0001727_abnormal_embryo_implantation	0.67192954
85	MP0003878_abnormal_ear_physiology	0.66917531
86	MP0005377_hearing/vestibular/ear_phenot	0.66917531
87	MP0008775_abnormal_heart_ventricle	0.65898807
88	MP0002229_neurodegeneration	0.65567740
89	MP0009697_abnormal_copulation	0.63811549
90	MP0002168_other_aberrant_phenotype	0.63805960
91	MP0005389_reproductive_system_phenotype	0.62418512
92	MP0002064_seizures	0.61702802
93	MP0000427_abnormal_hair_cycle	0.60184000
94	MP0003693_abnormal_embryo_hatching	0.59858979
95	MP0005367_renal/urinary_system_phenotyp	0.59076210
96	MP0000516_abnormal_urinary_system	0.59076210
97	MP0005319_abnormal_enzyme/_coenzyme	0.58582166
98	MP0002160_abnormal_reproductive_system	0.58450834
99	MP0003786_premature_aging	0.58180001
100	MP0005266_abnormal_metabolism	0.56434763

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.53085525
2	Abnormality of midbrain morphology (HP:0002418)	4.22548719
3	Molar tooth sign on MRI (HP:0002419)	4.22548719
4	Focal motor seizures (HP:0011153)	4.20988260
5	Pancreatic cysts (HP:0001737)	4.20931051
6	Decreased central vision (HP:0007663)	3.62765257
7	Aplastic anemia (HP:0001915)	3.61083166
8	Congenital stationary night blindness (HP:0007642)	3.28207748
9	Acute necrotizing encephalopathy (HP:0006965)	3.27874676
10	Pancreatic fibrosis (HP:0100732)	3.26774320
11	Retinal dysplasia (HP:0007973)	3.19649988
12	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.15000736
13	Amelogenesis imperfecta (HP:0000705)	3.13491051
14	Prostate neoplasm (HP:0100787)	3.12721993
15	Pendular nystagmus (HP:0012043)	3.12143145
16	Acute encephalopathy (HP:0006846)	3.08158773
17	Dry hair (HP:0011359)	3.03031563
18	Hypomagnesemia (HP:0002917)	3.02842661
19	Abnormality of the renal medulla (HP:0100957)	2.99802504
20	Nephronophthisis (HP:0000090)	2.99317089
21	Abnormality of the renal cortex (HP:0011035)	2.94655028
22	3-Methylglutaconic aciduria (HP:0003535)	2.82102110
23	Cystic liver disease (HP:0006706)	2.81688580
24	Abnormality of the prostate (HP:0008775)	2.76402423
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.74369277
26	Abnormal drinking behavior (HP:0030082)	2.71458377
27	Polydipsia (HP:0001959)	2.71458377
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.70956182
29	Progressive macrocephaly (HP:0004481)	2.70239130
30	Potter facies (HP:0002009)	2.70129731
31	Facial shape deformation (HP:0011334)	2.70129731
32	Parakeratosis (HP:0001036)	2.70066819
33	Mitochondrial inheritance (HP:0001427)	2.68186454
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.66978782
35	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.65079106
36	Abnormality of magnesium homeostasis (HP:0004921)	2.60645255
37	Type II lissencephaly (HP:0007260)	2.59888427
38	Keratoconus (HP:0000563)	2.56725434
39	Increased corneal curvature (HP:0100692)	2.56725434
40	Polyuria (HP:0000103)	2.55650884
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.54266074
42	Absent/shortened dynein arms (HP:0200106)	2.54266074
43	Increased CSF lactate (HP:0002490)	2.50520690
44	Fair hair (HP:0002286)	2.47485777
45	Abolished electroretinogram (ERG) (HP:0000550)	2.40569232
46	IgG deficiency (HP:0004315)	2.40172404
47	Abnormal biliary tract physiology (HP:0012439)	2.39932677
48	Bile duct proliferation (HP:0001408)	2.39932677
49	Abnormal urine output (HP:0012590)	2.38926043
50	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.33614857
51	Petechiae (HP:0000967)	2.32498873
52	Optic disc pallor (HP:0000543)	2.31860281
53	True hermaphroditism (HP:0010459)	2.31091683
54	Hyperglycinuria (HP:0003108)	2.28921199
55	Attenuation of retinal blood vessels (HP:0007843)	2.23479236
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.19482079
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.19482079
58	Abnormality of the axillary hair (HP:0100134)	2.18225889
59	Abnormality of secondary sexual hair (HP:0009888)	2.18225889
60	Type I transferrin isoform profile (HP:0003642)	2.13444100
61	Woolly hair (HP:0002224)	2.10523552
62	Congenital hepatic fibrosis (HP:0002612)	2.08772549
63	Chronic diarrhea (HP:0002028)	2.07852504
64	Pancytopenia (HP:0001876)	2.07508914
65	Abnormality of renal excretion (HP:0011036)	2.06668231
66	Increased serum lactate (HP:0002151)	2.06612422
67	Agitation (HP:0000713)	2.03827858
68	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.02181902
69	Stomach cancer (HP:0012126)	1.98726409
70	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.98393631
71	Hepatocellular necrosis (HP:0001404)	1.97530763
72	Focal seizures (HP:0007359)	1.97073389
73	Abnormality of male internal genitalia (HP:0000022)	1.95953493
74	Sclerocornea (HP:0000647)	1.94497437
75	Asplenia (HP:0001746)	1.92113110
76	Macular degeneration (HP:0000608)	1.90881163
77	Lactic acidosis (HP:0003128)	1.90880080
78	Abnormal ciliary motility (HP:0012262)	1.90363335
79	Tubulointerstitial fibrosis (HP:0005576)	1.89929364
80	Hepatic necrosis (HP:0002605)	1.89183059
81	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89109076
82	Abnormal protein N-linked glycosylation (HP:0012347)	1.89050962
83	Abnormal protein glycosylation (HP:0012346)	1.89050962
84	Abnormal glycosylation (HP:0012345)	1.89050962
85	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.89050962
86	Genetic anticipation (HP:0003743)	1.88747773
87	Erythroderma (HP:0001019)	1.87984644
88	Supernumerary spleens (HP:0009799)	1.87575672
89	Abnormality of macular pigmentation (HP:0008002)	1.86008904
90	Enlarged epiphyses (HP:0010580)	1.85445899
91	Difficulty walking (HP:0002355)	1.84365028
92	Split foot (HP:0001839)	1.83755171
93	Hypokalemic alkalosis (HP:0001949)	1.81373922
94	Hypoproteinemia (HP:0003075)	1.80748964
95	Hematochezia (HP:0002573)	1.78732621
96	Abnormality of T cell physiology (HP:0011840)	1.77640268
97	Microvesicular hepatic steatosis (HP:0001414)	1.77290752
98	Severe visual impairment (HP:0001141)	1.76265617
99	Chronic bronchitis (HP:0004469)	1.75694176
100	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.74100219

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	5.33103263
2	STK38L	4.41708639
3	LATS1	4.22666014
4	ZAK	3.96842053
5	PINK1	3.51653427
6	FRK	3.34425412
7	TLK1	3.07677544
8	BMPR1B	2.39293195
9	LATS2	2.12006270
10	WNK4	2.07420005
11	ADRBK2	1.98064090
12	PHKG2	1.81416381
13	PHKG1	1.81416381
14	GRK1	1.72145748
15	ACVR1B	1.70905404
16	KIT	1.64326552
17	TNK2	1.45685941
18	CSNK1A1L	1.42154677
19	NUAK1	1.35918475
20	OXSR1	1.34406558
21	CDK19	1.30380233
22	EIF2AK3	1.30201072
23	PLK2	1.20857503
24	FES	1.19458768
25	DAPK2	1.16979594
26	TEC	1.15775213
27	CDK8	1.15417037
28	SYK	1.13660396
29	CSNK1G3	1.09921989
30	STK3	1.08354191
31	ITK	1.07352399
32	MAP4K1	1.04005869
33	CAMKK2	1.03474378
34	PRKCE	1.02474668
35	MAP2K2	1.01853374
36	KDR	0.98016080
37	PIK3CG	0.96817976
38	NEK2	0.93258376
39	CSNK1G2	0.92775551
40	MAP3K12	0.92725349
41	INSRR	0.91092828
42	GRK6	0.90556359
43	VRK2	0.90556299
44	PTK2B	0.89462556
45	ADRBK1	0.89253745
46	JAK3	0.88002458
47	TXK	0.85325648
48	CAMKK1	0.82328015
49	LYN	0.81256039
50	MYLK	0.77437508
51	CSNK1G1	0.77075650
52	IKBKB	0.74441256
53	FER	0.74134985
54	CSF1R	0.72785571
55	WNK3	0.72666247
56	PASK	0.71500166
57	PRKCI	0.69755052
58	TTK	0.69372942
59	RIPK4	0.68951386
60	STK39	0.67193258
61	TIE1	0.67051368
62	GRK7	0.65795526
63	BTK	0.65316439
64	MAP4K2	0.64156440
65	DYRK2	0.62623387
66	ATR	0.57948771
67	IRAK3	0.57022781
68	VRK1	0.56803678
69	CHEK2	0.56687098
70	PRKAA2	0.56358282
71	TAF1	0.56338817
72	ERBB2	0.55698607
73	BRSK2	0.53601167
74	TGFBR1	0.53175695
75	STK38	0.49274237
76	PLK4	0.48635699
77	PIM1	0.47594672
78	PRKACA	0.45971196
79	PRKCQ	0.45901898
80	PIK3CA	0.44710895
81	PRKG2	0.44493763
82	BUB1	0.44024206
83	OBSCN	0.43793093
84	LCK	0.42001987
85	IGF1R	0.41111206
86	MAP3K4	0.39537960
87	ABL1	0.38459565
88	CDK3	0.38071065
89	IKBKE	0.37781317
90	PLK1	0.37600936
91	BCKDK	0.37262496
92	PRKD3	0.35975311
93	EIF2AK2	0.35382333
94	RPS6KA5	0.33800525
95	GRK5	0.33513828
96	MKNK2	0.33020570
97	PRKCA	0.31736372
98	HCK	0.31638841
99	NLK	0.29630358
100	CSNK1A1	0.27735488

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.77840827
2	Allograft rejection_Homo sapiens_hsa05330	4.04783070
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.85606643
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.85116071
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.78881515
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.15471612
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.95697286
8	Phototransduction_Homo sapiens_hsa04744	2.68388254
9	Viral myocarditis_Homo sapiens_hsa05416	2.61342347
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.31140742
11	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.27223427
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.98723262
13	Antigen processing and presentation_Homo sapiens_hsa04612	1.94763546
14	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.91231244
15	Ribosome_Homo sapiens_hsa03010	1.85537075
16	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.79450314
17	Parkinsons disease_Homo sapiens_hsa05012	1.73487251
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.66269714
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.64220963
20	RNA polymerase_Homo sapiens_hsa03020	1.49352565
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48772091
22	Proteasome_Homo sapiens_hsa03050	1.40640695
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.37275831
24	Sulfur metabolism_Homo sapiens_hsa00920	1.31303088
25	Alzheimers disease_Homo sapiens_hsa05010	1.30144249
26	Homologous recombination_Homo sapiens_hsa03440	1.26684902
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23960877
28	Huntingtons disease_Homo sapiens_hsa05016	1.18908301
29	Nicotine addiction_Homo sapiens_hsa05033	1.16747872
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.16171706
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16012763
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15815956
33	Leishmaniasis_Homo sapiens_hsa05140	1.14870235
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.11949305
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.10596481
36	Morphine addiction_Homo sapiens_hsa05032	1.07100237
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.02396939
38	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99178053
39	Taste transduction_Homo sapiens_hsa04742	0.92679688
40	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.92664544
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.92380042
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92254017
43	RNA degradation_Homo sapiens_hsa03018	0.92104537
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83263656
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78601804
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.75146882
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73843904
48	Primary immunodeficiency_Homo sapiens_hsa05340	0.72633996
49	Protein export_Homo sapiens_hsa03060	0.71444727
50	Olfactory transduction_Homo sapiens_hsa04740	0.69800029
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67496992
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66864301
53	Tuberculosis_Homo sapiens_hsa05152	0.66486488
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.65548324
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65351797
56	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65233109
57	GABAergic synapse_Homo sapiens_hsa04727	0.64368220
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.60766965
59	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58969666
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.53955360
61	Selenocompound metabolism_Homo sapiens_hsa00450	0.51298748
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51150638
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50439834
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49799631
65	Purine metabolism_Homo sapiens_hsa00230	0.49025288
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.48721188
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47551888
68	Basal transcription factors_Homo sapiens_hsa03022	0.47387808
69	Serotonergic synapse_Homo sapiens_hsa04726	0.45537892
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45340925
71	Phagosome_Homo sapiens_hsa04145	0.45142471
72	Regulation of autophagy_Homo sapiens_hsa04140	0.43878828
73	Butanoate metabolism_Homo sapiens_hsa00650	0.43705942
74	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43213952
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41984308
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40378929
77	Pyrimidine metabolism_Homo sapiens_hsa00240	0.40127208
78	ABC transporters_Homo sapiens_hsa02010	0.39770196
79	Metabolic pathways_Homo sapiens_hsa01100	0.38912081
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.38784819
81	Toxoplasmosis_Homo sapiens_hsa05145	0.38687292
82	Salivary secretion_Homo sapiens_hsa04970	0.37026923
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34905700
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34118662
85	Circadian entrainment_Homo sapiens_hsa04713	0.32228667
86	Peroxisome_Homo sapiens_hsa04146	0.30470132
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.30077779
88	Histidine metabolism_Homo sapiens_hsa00340	0.29652886
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27924105
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.27347461
91	One carbon pool by folate_Homo sapiens_hsa00670	0.27127985
92	Herpes simplex infection_Homo sapiens_hsa05168	0.26644603
93	Caffeine metabolism_Homo sapiens_hsa00232	0.25999611
94	Retinol metabolism_Homo sapiens_hsa00830	0.25874515
95	Bile secretion_Homo sapiens_hsa04976	0.25196054
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.22484712
97	Insulin secretion_Homo sapiens_hsa04911	0.22166403
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.21448873
99	Phenylalanine metabolism_Homo sapiens_hsa00360	0.21416514
100	Propanoate metabolism_Homo sapiens_hsa00640	0.21298368

RPS3AP50

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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