ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.02576608
2	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.27872367
3	viral transcription (GO:0019083)	5.22695633
4	DNA deamination (GO:0045006)	5.03784660
5	translational termination (GO:0006415)	5.03003292
6	protein neddylation (GO:0045116)	4.61141627
7	maturation of SSU-rRNA (GO:0030490)	4.55705079
8	translational elongation (GO:0006414)	4.54697538
9	ribosomal large subunit biogenesis (GO:0042273)	4.54318366
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.40082559
11	pyrimidine nucleotide catabolic process (GO:0006244)	4.38060427
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.36829967
13	ATP synthesis coupled proton transport (GO:0015986)	4.36829967
14	cotranslational protein targeting to membrane (GO:0006613)	4.33524321
15	protein targeting to ER (GO:0045047)	4.29056574
16	base-excision repair, AP site formation (GO:0006285)	4.23236498
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.07151627
18	ribosomal small subunit biogenesis (GO:0042274)	4.06843547
19	protein localization to endoplasmic reticulum (GO:0070972)	4.06634106
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.03386748
21	behavioral response to nicotine (GO:0035095)	4.00270895
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.97025128
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.97025128
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.84467576
25	NADH dehydrogenase complex assembly (GO:0010257)	3.84467576
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.84467576
27	viral life cycle (GO:0019058)	3.77241484
28	translational initiation (GO:0006413)	3.69201704
29	protein complex biogenesis (GO:0070271)	3.68614065
30	cytidine metabolic process (GO:0046087)	3.67754854
31	cytidine catabolic process (GO:0006216)	3.67754854
32	cytidine deamination (GO:0009972)	3.67754854
33	cellular protein complex disassembly (GO:0043624)	3.67395184
34	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.54788498
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.54387872
36	response to pheromone (GO:0019236)	3.48662125
37	GTP biosynthetic process (GO:0006183)	3.42317441
38	chaperone-mediated protein transport (GO:0072321)	3.38939558
39	water-soluble vitamin biosynthetic process (GO:0042364)	3.33901560
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.33222180
41	deoxyribonucleotide catabolic process (GO:0009264)	3.30280049
42	translation (GO:0006412)	3.24322199
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.22646088
44	proteasome assembly (GO:0043248)	3.20475079
45	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.19286682
46	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.19011601
47	deoxyribose phosphate catabolic process (GO:0046386)	3.18722839
48	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.02935860
49	respiratory electron transport chain (GO:0022904)	3.00900817
50	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.00771452
51	electron transport chain (GO:0022900)	3.00455688
52	cellular component biogenesis (GO:0044085)	2.97963395
53	piRNA metabolic process (GO:0034587)	2.95177671
54	ribonucleoprotein complex biogenesis (GO:0022613)	2.94807064
55	positive regulation of defense response to virus by host (GO:0002230)	2.92139092
56	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.91299253
57	protein complex disassembly (GO:0043241)	2.90078847
58	pseudouridine synthesis (GO:0001522)	2.89262973
59	macromolecular complex disassembly (GO:0032984)	2.85702832
60	UTP biosynthetic process (GO:0006228)	2.79713439
61	rRNA processing (GO:0006364)	2.75226519
62	UTP metabolic process (GO:0046051)	2.73957954
63	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.73809709
64	rRNA metabolic process (GO:0016072)	2.72632401
65	organelle disassembly (GO:1903008)	2.68903361
66	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.67670384
67	regulation of action potential (GO:0098900)	2.67515264
68	hydrogen ion transmembrane transport (GO:1902600)	2.66522308
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.66274998
70	purine nucleotide salvage (GO:0032261)	2.64456834
71	preassembly of GPI anchor in ER membrane (GO:0016254)	2.60631807
72	mRNA catabolic process (GO:0006402)	2.58043409
73	protein targeting to membrane (GO:0006612)	2.57891678
74	cellular ketone body metabolic process (GO:0046950)	2.57656029
75	metallo-sulfur cluster assembly (GO:0031163)	2.54907651
76	iron-sulfur cluster assembly (GO:0016226)	2.54907651
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.54816181
78	L-fucose catabolic process (GO:0042355)	2.54691380
79	fucose catabolic process (GO:0019317)	2.54691380
80	L-fucose metabolic process (GO:0042354)	2.54691380
81	male meiosis I (GO:0007141)	2.54618059
82	rRNA modification (GO:0000154)	2.51456098
83	positive regulation of interleukin-17 production (GO:0032740)	2.49895921
84	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.48636817
85	indolalkylamine metabolic process (GO:0006586)	2.47562594
86	GPI anchor metabolic process (GO:0006505)	2.46777376
87	tRNA processing (GO:0008033)	2.46168220
88	positive regulation of respiratory burst (GO:0060267)	2.45942092
89	proton transport (GO:0015992)	2.45545360
90	arginine metabolic process (GO:0006525)	2.43660970
91	hydrogen transport (GO:0006818)	2.42974817
92	platelet dense granule organization (GO:0060155)	2.42523009
93	ATP biosynthetic process (GO:0006754)	2.42261595
94	synapsis (GO:0007129)	2.41399083
95	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.40859888
96	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.40633035
97	ketone body metabolic process (GO:1902224)	2.39866985
98	CTP metabolic process (GO:0046036)	2.38886589
99	CTP biosynthetic process (GO:0006241)	2.38886589
100	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.37595403

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.04182318
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.64585693
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.30262356
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.91123286
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.81314847
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.71039442
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.70492556
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.66094954
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.52011386
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26985287
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.20166163
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.18545375
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.13199396
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11114735
15	EWS_26573619_Chip-Seq_HEK293_Human	1.99622786
16	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.99349671
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.94346148
18	MYC_18940864_ChIP-ChIP_HL60_Human	1.93353771
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.92272900
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.92217262
21	FUS_26573619_Chip-Seq_HEK293_Human	1.85751924
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84291953
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.81702086
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.71214375
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.69971463
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68619479
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.68459118
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.57137015
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.57137015
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56935247
31	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.56578472
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54954607
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.51207219
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48055760
35	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.47527392
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.47486369
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.47420561
38	NCOR_22424771_ChIP-Seq_293T_Human	1.47153200
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46617352
40	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.45391603
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45246237
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44260938
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.44250031
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.42491464
45	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38258859
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.36466626
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34685064
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34685064
49	P300_19829295_ChIP-Seq_ESCs_Human	1.32740337
50	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.30576643
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.27665358
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27665358
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26885105
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26305467
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25568168
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25473773
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23912078
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23275414
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23132759
60	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22970685
61	AR_20517297_ChIP-Seq_VCAP_Human	1.22205677
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21723777
63	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.21471373
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20946960
65	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17275359
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16844173
67	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11503272
68	TTF2_22483619_ChIP-Seq_HELA_Human	1.10255972
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10216037
70	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06697849
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06498414
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06244408
73	GATA3_26560356_Chip-Seq_TH2_Human	1.05680563
74	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04176647
75	ERG_20517297_ChIP-Seq_VCAP_Human	1.02635332
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02461258
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02384657
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01790206
79	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.01098372
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00155050
81	MYC_19829295_ChIP-Seq_ESCs_Human	0.99176001
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98537363
83	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97108128
84	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.96646544
85	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96620889
86	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.96526287
87	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96461237
88	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.95642411
89	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.95349954
90	ERA_21632823_ChIP-Seq_H3396_Human	0.94713376
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.94403736
92	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94032841
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93448009
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.92776110
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.91938041
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.91585115
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.89835210
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.88120912
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.87827653
100	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.87193647

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.34269211
2	MP0006292_abnormal_olfactory_placode	3.76086302
3	MP0005671_abnormal_response_to	2.44455821
4	MP0005645_abnormal_hypothalamus_physiol	2.37386042
5	MP0002102_abnormal_ear_morphology	2.29883188
6	MP0004147_increased_porphyrin_level	2.28777992
7	MP0001835_abnormal_antigen_presentation	2.16059966
8	MP0005084_abnormal_gallbladder_morpholo	2.07166342
9	MP0003646_muscle_fatigue	2.06397497
10	MP0008877_abnormal_DNA_methylation	2.02900536
11	MP0001873_stomach_inflammation	2.01731572
12	MP0002138_abnormal_hepatobiliary_system	1.98808838
13	MP0002837_dystrophic_cardiac_calcinosis	1.93041587
14	MP0008872_abnormal_physiological_respon	1.92596811
15	MP0008995_early_reproductive_senescence	1.83747124
16	MP0004885_abnormal_endolymph	1.78488504
17	MP0002160_abnormal_reproductive_system	1.69210215
18	MP0005646_abnormal_pituitary_gland	1.65883978
19	MP0002876_abnormal_thyroid_physiology	1.64879746
20	MP0003806_abnormal_nucleotide_metabolis	1.61928065
21	MP0005389_reproductive_system_phenotype	1.57690776
22	MP0005360_urolithiasis	1.57413943
23	MP0005551_abnormal_eye_electrophysiolog	1.54039357
24	MP0004145_abnormal_muscle_electrophysio	1.52552619
25	MP0005075_abnormal_melanosome_morpholog	1.50677624
26	MP0006072_abnormal_retinal_apoptosis	1.48091360
27	MP0001764_abnormal_homeostasis	1.47770586
28	MP0000372_irregular_coat_pigmentation	1.46565204
29	MP0004142_abnormal_muscle_tone	1.44458004
30	MP0003787_abnormal_imprinting	1.40436755
31	MP0002234_abnormal_pharynx_morphology	1.36803816
32	MP0001968_abnormal_touch/_nociception	1.35448785
33	MP0008875_abnormal_xenobiotic_pharmacok	1.33601377
34	MP0009785_altered_susceptibility_to	1.31969749
35	MP0001293_anophthalmia	1.31497905
36	MP0001800_abnormal_humoral_immune	1.30626126
37	MP0002653_abnormal_ependyma_morphology	1.29366495
38	MP0009333_abnormal_splenocyte_physiolog	1.29014631
39	MP0003186_abnormal_redox_activity	1.28516089
40	MP0003718_maternal_effect	1.24806503
41	MP0001188_hyperpigmentation	1.24514895
42	MP0005387_immune_system_phenotype	1.24386035
43	MP0001790_abnormal_immune_system	1.24386035
44	MP0000678_abnormal_parathyroid_gland	1.23721249
45	MP0002148_abnormal_hypersensitivity_rea	1.22777308
46	MP0001485_abnormal_pinna_reflex	1.22081674
47	MP0001919_abnormal_reproductive_system	1.22001813
48	MP0001905_abnormal_dopamine_level	1.21544156
49	MP0002163_abnormal_gland_morphology	1.18218082
50	MP0002095_abnormal_skin_pigmentation	1.18004691
51	MP0000685_abnormal_immune_system	1.16489910
52	MP0008775_abnormal_heart_ventricle	1.16243069
53	MP0008058_abnormal_DNA_repair	1.15348853
54	MP0002277_abnormal_respiratory_mucosa	1.14045083
55	MP0005174_abnormal_tail_pigmentation	1.13683621
56	MP0002166_altered_tumor_susceptibility	1.09455308
57	MP0002736_abnormal_nociception_after	1.06911159
58	MP0003183_abnormal_peptide_metabolism	1.05825103
59	MP0005253_abnormal_eye_physiology	1.05306564
60	MP0001986_abnormal_taste_sensitivity	1.04674286
61	MP0003763_abnormal_thymus_physiology	1.04107596
62	MP0002938_white_spotting	1.02428350
63	MP0005000_abnormal_immune_tolerance	1.02031593
64	MP0003786_premature_aging	0.99187283
65	MP0003252_abnormal_bile_duct	0.98953856
66	MP0010155_abnormal_intestine_physiology	0.98744137
67	MP0005085_abnormal_gallbladder_physiolo	0.97408065
68	MP0002006_tumorigenesis	0.97064610
69	MP0005636_abnormal_mineral_homeostasis	0.96724793
70	MP0000049_abnormal_middle_ear	0.95615025
71	MP0003567_abnormal_fetal_cardiomyocyte	0.93707257
72	MP0002723_abnormal_immune_serum	0.93130358
73	MP0001440_abnormal_grooming_behavior	0.92908702
74	MP0002638_abnormal_pupillary_reflex	0.92297282
75	MP0006036_abnormal_mitochondrial_physio	0.91334242
76	MP0006276_abnormal_autonomic_nervous	0.88972762
77	MP0003283_abnormal_digestive_organ	0.88713203
78	MP0000631_abnormal_neuroendocrine_gland	0.87999180
79	MP0001663_abnormal_digestive_system	0.87040512
80	MP0003195_calcinosis	0.86803011
81	MP0002272_abnormal_nervous_system	0.86310535
82	MP0005332_abnormal_amino_acid	0.85756654
83	MP0001765_abnormal_ion_homeostasis	0.82535867
84	MP0004742_abnormal_vestibular_system	0.81485670
85	MP0001529_abnormal_vocalization	0.80621694
86	MP0004019_abnormal_vitamin_homeostasis	0.78669555
87	MP0002420_abnormal_adaptive_immunity	0.77023463
88	MP0001819_abnormal_immune_cell	0.76448312
89	MP0002452_abnormal_antigen_presenting	0.75053443
90	MP0008789_abnormal_olfactory_epithelium	0.74467299
91	MP0003693_abnormal_embryo_hatching	0.74256281
92	MP0003866_abnormal_defecation	0.73249927
93	MP0002733_abnormal_thermal_nociception	0.72396885
94	MP0000230_abnormal_systemic_arterial	0.71689337
95	MP0005410_abnormal_fertilization	0.71543470
96	MP0000681_abnormal_thyroid_gland	0.70848566
97	MP0002928_abnormal_bile_duct	0.70832916
98	MP0000427_abnormal_hair_cycle	0.70497287
99	MP0005195_abnormal_posterior_eye	0.69446061
100	MP0001970_abnormal_pain_threshold	0.69176186

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	3.80532226
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.71403934
3	Reticulocytopenia (HP:0001896)	3.60606516
4	Acute necrotizing encephalopathy (HP:0006965)	3.51788385
5	Abnormality of cells of the erythroid lineage (HP:0012130)	3.37718196
6	Absent/shortened dynein arms (HP:0200106)	3.36073037
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.36073037
8	Molar tooth sign on MRI (HP:0002419)	3.32900356
9	Abnormality of midbrain morphology (HP:0002418)	3.32900356
10	Increased hepatocellular lipid droplets (HP:0006565)	3.32446406
11	Mitochondrial inheritance (HP:0001427)	3.31847278
12	3-Methylglutaconic aciduria (HP:0003535)	3.25908357
13	Acute encephalopathy (HP:0006846)	3.23267780
14	Renal Fanconi syndrome (HP:0001994)	3.19227072
15	Lipid accumulation in hepatocytes (HP:0006561)	3.18802011
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.13623873
17	Increased CSF lactate (HP:0002490)	3.09513120
18	Abnormal mitochondria in muscle tissue (HP:0008316)	3.03322289
19	Pancreatic cysts (HP:0001737)	2.92411124
20	Macrocytic anemia (HP:0001972)	2.88822047
21	Progressive macrocephaly (HP:0004481)	2.88572611
22	Abnormal respiratory epithelium morphology (HP:0012253)	2.86496991
23	Abnormal respiratory motile cilium morphology (HP:0005938)	2.86496991
24	Pancreatic fibrosis (HP:0100732)	2.86344753
25	Stenosis of the external auditory canal (HP:0000402)	2.78238322
26	Abnormal number of erythroid precursors (HP:0012131)	2.76940459
27	Elevated erythrocyte sedimentation rate (HP:0003565)	2.74190324
28	Abolished electroretinogram (ERG) (HP:0000550)	2.73558360
29	True hermaphroditism (HP:0010459)	2.71435517
30	Increased intramyocellular lipid droplets (HP:0012240)	2.67356999
31	Glycosuria (HP:0003076)	2.61771325
32	Abnormality of urine glucose concentration (HP:0011016)	2.61771325
33	Methylmalonic acidemia (HP:0002912)	2.59691985
34	Hepatocellular necrosis (HP:0001404)	2.59671254
35	IgG deficiency (HP:0004315)	2.55624531
36	Hyperglycinemia (HP:0002154)	2.55367287
37	Optic disc pallor (HP:0000543)	2.53059419
38	Abnormality of B cell number (HP:0010975)	2.52460788
39	Constricted visual fields (HP:0001133)	2.47701686
40	Hepatic necrosis (HP:0002605)	2.47283606
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.45020982
42	B lymphocytopenia (HP:0010976)	2.41731710
43	Exertional dyspnea (HP:0002875)	2.41533986
44	Panhypogammaglobulinemia (HP:0003139)	2.38092237
45	Pallor (HP:0000980)	2.37792353
46	Severe combined immunodeficiency (HP:0004430)	2.32791953
47	Supernumerary spleens (HP:0009799)	2.32103346
48	Increased serum lactate (HP:0002151)	2.31595646
49	Generalized aminoaciduria (HP:0002909)	2.29478163
50	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.29393222
51	Cerebral edema (HP:0002181)	2.28378773
52	Abnormal hemoglobin (HP:0011902)	2.27145515
53	Nephronophthisis (HP:0000090)	2.27031777
54	Thyroiditis (HP:0100646)	2.25475007
55	Increased muscle lipid content (HP:0009058)	2.23869539
56	Pendular nystagmus (HP:0012043)	2.22534705
57	Abnormality of renal resorption (HP:0011038)	2.17049718
58	Hyperphosphaturia (HP:0003109)	2.16120213
59	Decreased central vision (HP:0007663)	2.15420269
60	Abnormal ciliary motility (HP:0012262)	2.14492286
61	Chronic sinusitis (HP:0011109)	2.14174119
62	Attenuation of retinal blood vessels (HP:0007843)	2.13346494
63	Renal cortical cysts (HP:0000803)	2.13265950
64	Agammaglobulinemia (HP:0004432)	2.11931150
65	Type 2 muscle fiber atrophy (HP:0003554)	2.11918635
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.11202627
67	Abnormality of alanine metabolism (HP:0010916)	2.11202627
68	Hyperalaninemia (HP:0003348)	2.11202627
69	Methylmalonic aciduria (HP:0012120)	2.10465288
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.10360142
71	Abnormality of the renal cortex (HP:0011035)	2.09521481
72	Absent thumb (HP:0009777)	2.06162562
73	Lethargy (HP:0001254)	2.02244250
74	Lactic acidosis (HP:0003128)	2.01004133
75	Abnormal respiratory motile cilium physiology (HP:0012261)	2.00431201
76	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.00140805
77	Sclerocornea (HP:0000647)	1.99000416
78	Hypoproteinemia (HP:0003075)	1.98945483
79	Abnormality of the prostate (HP:0008775)	1.98107965
80	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97246807
81	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97246807
82	Concave nail (HP:0001598)	1.91334538
83	Polydipsia (HP:0001959)	1.91307148
84	Abnormal drinking behavior (HP:0030082)	1.91307148
85	Type II lissencephaly (HP:0007260)	1.88963424
86	Abnormality of vitamin B metabolism (HP:0004340)	1.88610398
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.88461677
88	Asplenia (HP:0001746)	1.88433387
89	Hyperglycinuria (HP:0003108)	1.87789924
90	Abnormality of the labia minora (HP:0012880)	1.87560950
91	Chronic hepatic failure (HP:0100626)	1.86401765
92	Increased corneal curvature (HP:0100692)	1.85716893
93	Keratoconus (HP:0000563)	1.85716893
94	Colon cancer (HP:0003003)	1.82934712
95	Abnormality of glycine metabolism (HP:0010895)	1.80770913
96	Abnormality of serine family amino acid metabolism (HP:0010894)	1.80770913
97	Abnormality of the renal medulla (HP:0100957)	1.80171928
98	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.79339917
99	Stomatitis (HP:0010280)	1.78223229
100	Respiratory difficulties (HP:0002880)	1.78170000

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	2.97538543
2	GRK1	2.90680907
3	ADRBK2	2.80481010
4	TXK	2.79879648
5	MAP4K2	2.79016583
6	ZAK	2.39796747
7	FRK	2.27252495
8	TLK1	2.26024008
9	BCKDK	2.20088922
10	TAOK3	2.11225125
11	NUAK1	2.08430045
12	STK16	1.93437127
13	EIF2AK3	1.85410483
14	VRK2	1.82192506
15	TIE1	1.75198874
16	TEC	1.70217853
17	WNK3	1.68479650
18	VRK1	1.63874393
19	KIT	1.51406340
20	WNK4	1.45957755
21	ACVR1B	1.38113694
22	PINK1	1.31970627
23	MAP4K1	1.31547631
24	BMPR1B	1.29043101
25	INSRR	1.26080470
26	SYK	1.24988291
27	MST4	1.18429586
28	ITK	1.18141072
29	TNK2	1.16515332
30	MAP3K12	1.11692136
31	IKBKB	1.10132203
32	MKNK1	1.09430974
33	OXSR1	1.04022527
34	PRKCQ	1.02169629
35	STK39	1.01914398
36	PASK	1.01842079
37	BTK	0.98399983
38	KDR	0.94374213
39	IKBKE	0.94017473
40	DYRK2	0.93839707
41	PLK4	0.87452266
42	MKNK2	0.87427109
43	PRKG2	0.84839902
44	MAPK13	0.83052054
45	NME1	0.82731064
46	FLT3	0.80902568
47	RPS6KB2	0.80631843
48	CSF1R	0.80245563
49	MAP2K6	0.80124458
50	DAPK2	0.80032892
51	FES	0.77548317
52	SCYL2	0.73425615
53	STK38L	0.73084233
54	CDK3	0.72091518
55	PIK3CA	0.71548287
56	CCNB1	0.71060588
57	MUSK	0.69871997
58	ADRBK1	0.66855299
59	RPS6KA4	0.65627242
60	AURKA	0.63492091
61	NEK1	0.63426377
62	OBSCN	0.63332786
63	RPS6KA6	0.63114807
64	NLK	0.62160991
65	MAP3K4	0.62145912
66	DAPK3	0.62005527
67	RPS6KA5	0.60069560
68	EIF2AK2	0.59513570
69	PRKACA	0.59474819
70	ILK	0.58701719
71	PRKCH	0.58347523
72	CSNK2A2	0.58207865
73	LCK	0.58198714
74	PRKCG	0.57543983
75	TAF1	0.56503436
76	LYN	0.54526225
77	PIM1	0.54519323
78	CAMK1	0.54039351
79	CSNK1G1	0.52727181
80	PLK1	0.52353671
81	CSNK2A1	0.51368219
82	PRKCA	0.51315112
83	GRK5	0.50790903
84	RPS6KL1	0.49790812
85	RPS6KC1	0.49790812
86	GRK7	0.49051940
87	MAPKAPK5	0.48650110
88	PRKCE	0.48348627
89	PLK3	0.47567711
90	AURKB	0.46220351
91	NME2	0.43534646
92	PRKCD	0.43308250
93	CASK	0.42821513
94	RPS6KB1	0.41609549
95	ABL2	0.40678246
96	IGF1R	0.39055708
97	GRK6	0.38469779
98	TGFBR1	0.37870654
99	CAMKK2	0.37802508
100	JAK3	0.37648925

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.29150824
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.16299001
3	Asthma_Homo sapiens_hsa05310	2.86374477
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.62403338
5	Parkinsons disease_Homo sapiens_hsa05012	2.52131399
6	Proteasome_Homo sapiens_hsa03050	2.52129009
7	Allograft rejection_Homo sapiens_hsa05330	2.44398403
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.37148371
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.29532974
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.15841789
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.01491192
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.01238907
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.00987244
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.95204199
15	Protein export_Homo sapiens_hsa03060	1.77568528
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73390334
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.69854310
18	Alzheimers disease_Homo sapiens_hsa05010	1.62146470
19	Huntingtons disease_Homo sapiens_hsa05016	1.59312356
20	Propanoate metabolism_Homo sapiens_hsa00640	1.56901946
21	RNA polymerase_Homo sapiens_hsa03020	1.54734428
22	Homologous recombination_Homo sapiens_hsa03440	1.51474950
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.46446588
24	RNA degradation_Homo sapiens_hsa03018	1.44391471
25	Fat digestion and absorption_Homo sapiens_hsa04975	1.43497942
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.41680981
27	Phototransduction_Homo sapiens_hsa04744	1.37539087
28	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.37391736
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36976870
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.34372011
31	Caffeine metabolism_Homo sapiens_hsa00232	1.34368842
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.29490580
33	One carbon pool by folate_Homo sapiens_hsa00670	1.29438488
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.28098471
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.27314684
36	Butanoate metabolism_Homo sapiens_hsa00650	1.24856150
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22879358
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.18803137
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14304962
40	Peroxisome_Homo sapiens_hsa04146	1.11323803
41	Basal transcription factors_Homo sapiens_hsa03022	1.11309113
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08971450
43	Regulation of autophagy_Homo sapiens_hsa04140	1.08706001
44	Retinol metabolism_Homo sapiens_hsa00830	1.08405001
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07157553
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02434111
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00301175
48	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.99754790
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97963362
50	Rheumatoid arthritis_Homo sapiens_hsa05323	0.96957673
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95655432
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.95282314
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92554955
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92139391
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.91289601
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.88512005
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86361718
58	Olfactory transduction_Homo sapiens_hsa04740	0.84826140
59	Sulfur metabolism_Homo sapiens_hsa00920	0.82371162
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.81607574
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.78956726
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.78435841
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74880913
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.74224636
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.72777090
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.72446762
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72191805
68	Purine metabolism_Homo sapiens_hsa00230	0.70189497
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.69063818
70	Spliceosome_Homo sapiens_hsa03040	0.69011893
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68844112
72	Taste transduction_Homo sapiens_hsa04742	0.68456985
73	RNA transport_Homo sapiens_hsa03013	0.67369348
74	Nicotine addiction_Homo sapiens_hsa05033	0.65196088
75	Metabolic pathways_Homo sapiens_hsa01100	0.63883412
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.63830032
77	Base excision repair_Homo sapiens_hsa03410	0.63123561
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.63064353
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60666180
80	Sulfur relay system_Homo sapiens_hsa04122	0.53122540
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52795811
82	Mismatch repair_Homo sapiens_hsa03430	0.50496253
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45792922
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45324373
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44379126
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44226710
87	Glutathione metabolism_Homo sapiens_hsa00480	0.42843596
88	Serotonergic synapse_Homo sapiens_hsa04726	0.41428641
89	African trypanosomiasis_Homo sapiens_hsa05143	0.41389605
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40649638
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40442225
92	Salivary secretion_Homo sapiens_hsa04970	0.37917926
93	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.36051657
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.34605824
95	Fatty acid degradation_Homo sapiens_hsa00071	0.33614257
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.32626964
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31940431
98	Mineral absorption_Homo sapiens_hsa04978	0.31619539
99	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.27792174
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27577527

RPS3AP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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