ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.34126328
2	water-soluble vitamin biosynthetic process (GO:0042364)	5.15788155
3	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.11451124
4	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	4.95416643
5	regulation of chronic inflammatory response (GO:0002676)	4.94933231
6	maturation of 5.8S rRNA (GO:0000460)	4.59594767
7	rRNA modification (GO:0000154)	4.56167308
8	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.52348318
9	rRNA methylation (GO:0031167)	4.26261043
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.04133784
11	ribosome assembly (GO:0042255)	3.83755261
12	tryptophan metabolic process (GO:0006568)	3.78404630
13	kynurenine metabolic process (GO:0070189)	3.77038049
14	regulation of regulatory T cell differentiation (GO:0045589)	3.72948172
15	proteasome assembly (GO:0043248)	3.71404330
16	indole-containing compound catabolic process (GO:0042436)	3.69065585
17	indolalkylamine catabolic process (GO:0046218)	3.69065585
18	tryptophan catabolic process (GO:0006569)	3.69065585
19	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.68298257
20	peptidyl-histidine modification (GO:0018202)	3.63017079
21	positive regulation of interleukin-17 production (GO:0032740)	3.60383290
22	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.54775218
23	ATP synthesis coupled proton transport (GO:0015986)	3.54775218
24	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.49432493
25	pseudouridine synthesis (GO:0001522)	3.37417836
26	positive regulation of immunoglobulin mediated immune response (GO:0002891)	3.35979246
27	positive regulation of B cell mediated immunity (GO:0002714)	3.35979246
28	chaperone-mediated protein transport (GO:0072321)	3.31131906
29	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.30553414
30	cytidine deamination (GO:0009972)	3.30522193
31	cytidine metabolic process (GO:0046087)	3.30522193
32	cytidine catabolic process (GO:0006216)	3.30522193
33	GTP biosynthetic process (GO:0006183)	3.29678462
34	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.29442953
35	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.28183566
36	response to pheromone (GO:0019236)	3.26472590
37	indolalkylamine metabolic process (GO:0006586)	3.24395266
38	regulation of isotype switching to IgG isotypes (GO:0048302)	3.23356807
39	negative regulation of B cell apoptotic process (GO:0002903)	3.21498692
40	cullin deneddylation (GO:0010388)	3.20316259
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.17842412
42	regulation of inflammatory response to antigenic stimulus (GO:0002861)	3.17781883
43	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.14433872
44	tRNA modification (GO:0006400)	3.09951877
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07242331
46	positive regulation of humoral immune response (GO:0002922)	3.06930881
47	behavioral response to nicotine (GO:0035095)	3.05597119
48	DNA catabolic process, exonucleolytic (GO:0000738)	3.04575301
49	protein deneddylation (GO:0000338)	3.00934855
50	tRNA processing (GO:0008033)	3.00539030
51	activated T cell proliferation (GO:0050798)	2.99242013
52	ribosomal large subunit biogenesis (GO:0042273)	2.98734120
53	cell wall macromolecule metabolic process (GO:0044036)	2.98136515
54	regulation of cellular amino acid metabolic process (GO:0006521)	2.96173528
55	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.96169652
56	regulation of B cell apoptotic process (GO:0002902)	2.91619332
57	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.90624891
58	protein neddylation (GO:0045116)	2.90291345
59	mitochondrial DNA replication (GO:0006264)	2.89767323
60	L-fucose catabolic process (GO:0042355)	2.84275579
61	fucose catabolic process (GO:0019317)	2.84275579
62	L-fucose metabolic process (GO:0042354)	2.84275579
63	rRNA metabolic process (GO:0016072)	2.83750885
64	UTP biosynthetic process (GO:0006228)	2.83391986
65	UTP metabolic process (GO:0046051)	2.82556695
66	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.81776938
67	rRNA processing (GO:0006364)	2.80320815
68	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.79121915
69	regulation of immunoglobulin secretion (GO:0051023)	2.79064062
70	lysine metabolic process (GO:0006553)	2.75661266
71	lysine catabolic process (GO:0006554)	2.75661266
72	mitochondrial RNA metabolic process (GO:0000959)	2.75500687
73	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.73403635
74	amine catabolic process (GO:0009310)	2.72354232
75	cellular biogenic amine catabolic process (GO:0042402)	2.72354232
76	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.72092547
77	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.69979609
78	tRNA metabolic process (GO:0006399)	2.68848034
79	aspartate family amino acid catabolic process (GO:0009068)	2.67684241
80	intracellular protein transmembrane import (GO:0044743)	2.66964597
81	synapsis (GO:0007129)	2.65830133
82	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.65068575
83	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.60953513
84	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.60953513
85	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.60953513
86	vitamin biosynthetic process (GO:0009110)	2.60720184
87	male meiosis (GO:0007140)	2.60124640
88	positive regulation of activated T cell proliferation (GO:0042104)	2.59376398
89	DNA double-strand break processing (GO:0000729)	2.58842507
90	replication fork processing (GO:0031297)	2.57928242
91	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.56895260
92	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.56895260
93	electron transport chain (GO:0022900)	2.56877772
94	RNA modification (GO:0009451)	2.56313737
95	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.55298905
96	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.55298905
97	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.54661407
98	ncRNA processing (GO:0034470)	2.53915992
99	respiratory electron transport chain (GO:0022904)	2.53717162
100	ncRNA metabolic process (GO:0034660)	2.53302761

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.17974338
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.86412767
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.45257450
4	VDR_22108803_ChIP-Seq_LS180_Human	3.15556378
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.99624454
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.97660132
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.97272764
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.83140842
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.73179233
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.58308594
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.46010260
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.45267629
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.44566244
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.41289787
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.32562868
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.21664324
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18338426
18	EWS_26573619_Chip-Seq_HEK293_Human	2.09670928
19	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.09247798
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.97353081
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.95878474
22	FUS_26573619_Chip-Seq_HEK293_Human	1.94586105
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.92940609
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.91917600
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88970111
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.85897429
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.84638137
28	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.82856315
29	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.78493413
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73344530
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.72710517
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.70291564
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69519466
34	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.68227440
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.65401646
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.63713188
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60603079
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.48314604
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.48314604
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47032254
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.46816176
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45936468
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.45453543
44	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.45311728
45	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.45303890
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.39016158
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.38592315
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38041906
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38041906
50	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.37318689
51	AR_20517297_ChIP-Seq_VCAP_Human	1.37176331
52	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36915405
53	P300_19829295_ChIP-Seq_ESCs_Human	1.35060444
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33573154
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33239667
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.32782761
57	GATA3_26560356_Chip-Seq_TH2_Human	1.31125560
58	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.30179526
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.28840295
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.28779333
61	TTF2_22483619_ChIP-Seq_HELA_Human	1.28377525
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.26896965
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.26549825
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26145546
65	DCP1A_22483619_ChIP-Seq_HELA_Human	1.23847022
66	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.23028291
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22966995
68	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.20913377
69	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.17380183
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16228161
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14598948
72	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.13715017
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.12856548
74	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12175863
75	CIITA_25753668_ChIP-Seq_RAJI_Human	1.11937674
76	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.10220995
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07384080
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.07384080
79	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.06830880
80	GATA1_22025678_ChIP-Seq_K562_Human	1.04489762
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03636709
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03453681
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02823718
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.02426545
85	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98353775
86	GABP_19822575_ChIP-Seq_HepG2_Human	0.97709762
87	RBPJ_21746931_ChIP-Seq_IB4_Human	0.96302394
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95109459
89	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93253311
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92691288
91	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.92451854
92	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.91795969
93	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.89885269
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.88939989
95	GBX2_23144817_ChIP-Seq_PC3_Human	0.88139850
96	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88118147
97	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.87179204
98	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.87092824
99	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.85972393
100	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.85883056

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	3.91681965
2	MP0001835_abnormal_antigen_presentation	3.02987109
3	MP0002102_abnormal_ear_morphology	2.91238945
4	MP0003806_abnormal_nucleotide_metabolis	2.86298480
5	MP0005084_abnormal_gallbladder_morpholo	2.80021383
6	MP0000685_abnormal_immune_system	2.55539308
7	MP0002148_abnormal_hypersensitivity_rea	2.41469317
8	MP0002837_dystrophic_cardiac_calcinosis	2.31575803
9	MP0003786_premature_aging	2.11954895
10	MP0001501_abnormal_sleep_pattern	2.08511287
11	MP0002876_abnormal_thyroid_physiology	2.07179530
12	MP0005671_abnormal_response_to	2.02594157
13	MP0000372_irregular_coat_pigmentation	2.01684336
14	MP0002736_abnormal_nociception_after	1.98831063
15	MP0001873_stomach_inflammation	1.98727250
16	MP0009764_decreased_sensitivity_to	1.98113073
17	MP0005646_abnormal_pituitary_gland	1.97136790
18	MP0009785_altered_susceptibility_to	1.91525738
19	MP0003718_maternal_effect	1.88865072
20	MP0006292_abnormal_olfactory_placode	1.82882496
21	MP0003787_abnormal_imprinting	1.82023473
22	MP0003436_decreased_susceptibility_to	1.80077720
23	MP0008058_abnormal_DNA_repair	1.79610213
24	MP0008877_abnormal_DNA_methylation	1.74785570
25	MP0008872_abnormal_physiological_respon	1.74682202
26	MP0003172_abnormal_lysosome_physiology	1.72400924
27	MP0003866_abnormal_defecation	1.64998897
28	MP0001968_abnormal_touch/_nociception	1.64127176
29	MP0008875_abnormal_xenobiotic_pharmacok	1.58819180
30	MP0000465_gastrointestinal_hemorrhage	1.58533010
31	MP0001986_abnormal_taste_sensitivity	1.52813403
32	MP0001853_heart_inflammation	1.52547813
33	MP0003136_yellow_coat_color	1.52116778
34	MP0005670_abnormal_white_adipose	1.51655123
35	MP0003252_abnormal_bile_duct	1.50476816
36	MP0009697_abnormal_copulation	1.47391689
37	MP0006036_abnormal_mitochondrial_physio	1.44205750
38	MP0004782_abnormal_surfactant_physiolog	1.41787250
39	MP0003300_gastrointestinal_ulcer	1.40726289
40	MP0001800_abnormal_humoral_immune	1.40123857
41	MP0008775_abnormal_heart_ventricle	1.38819123
42	MP0005645_abnormal_hypothalamus_physiol	1.38083032
43	MP0006072_abnormal_retinal_apoptosis	1.31233333
44	MP0003195_calcinosis	1.26586667
45	MP0004142_abnormal_muscle_tone	1.25349547
46	MP0003724_increased_susceptibility_to	1.23505246
47	MP0008995_early_reproductive_senescence	1.22959210
48	MP0001984_abnormal_olfaction	1.22323970
49	MP0004145_abnormal_muscle_electrophysio	1.20479066
50	MP0002282_abnormal_trachea_morphology	1.20098979
51	MP0000566_synostosis	1.14320090
52	MP0005000_abnormal_immune_tolerance	1.14035387
53	MP0004885_abnormal_endolymph	1.13989304
54	MP0003303_peritoneal_inflammation	1.13385002
55	MP0001790_abnormal_immune_system	1.13336990
56	MP0005387_immune_system_phenotype	1.13336990
57	MP0002405_respiratory_system_inflammati	1.12138788
58	MP0005075_abnormal_melanosome_morpholog	1.09285378
59	MP0003186_abnormal_redox_activity	1.06073067
60	MP0002277_abnormal_respiratory_mucosa	1.04342179
61	MP0002723_abnormal_immune_serum	1.04086468
62	MP0003646_muscle_fatigue	1.03568955
63	MP0002234_abnormal_pharynx_morphology	1.02515401
64	MP0006035_abnormal_mitochondrial_morpho	1.02023895
65	MP0001440_abnormal_grooming_behavior	1.01580100
66	MP0005167_abnormal_blood-brain_barrier	0.98359831
67	MP0002452_abnormal_antigen_presenting	0.97465030
68	MP0003283_abnormal_digestive_organ	0.95903820
69	MP0002139_abnormal_hepatobiliary_system	0.93322733
70	MP0008007_abnormal_cellular_replicative	0.93095733
71	MP0002693_abnormal_pancreas_physiology	0.92921806
72	MP0008469_abnormal_protein_level	0.92437714
73	MP0005171_absent_coat_pigmentation	0.92116415
74	MP0001661_extended_life_span	0.89595474
75	MP0001845_abnormal_inflammatory_respons	0.89373396
76	MP0006082_CNS_inflammation	0.89363853
77	MP0002006_tumorigenesis	0.88698616
78	MP0001663_abnormal_digestive_system	0.88576521
79	MP0001819_abnormal_immune_cell	0.88523900
80	MP0002420_abnormal_adaptive_immunity	0.87894939
81	MP0001293_anophthalmia	0.87373654
82	MP0010155_abnormal_intestine_physiology	0.87136106
83	MP0000689_abnormal_spleen_morphology	0.86356662
84	MP0003878_abnormal_ear_physiology	0.86355977
85	MP0005377_hearing/vestibular/ear_phenot	0.86355977
86	MP0005085_abnormal_gallbladder_physiolo	0.86261727
87	MP0000569_abnormal_digit_pigmentation	0.86093059
88	MP0004957_abnormal_blastocyst_morpholog	0.84369508
89	MP0003011_delayed_dark_adaptation	0.83580292
90	MP0000230_abnormal_systemic_arterial	0.83484642
91	MP0002938_white_spotting	0.83320311
92	MP0005551_abnormal_eye_electrophysiolog	0.82928816
93	MP0001764_abnormal_homeostasis	0.82871298
94	MP0001533_abnormal_skeleton_physiology	0.82773836
95	MP0005165_increased_susceptibility_to	0.81033744
96	MP0004215_abnormal_myocardial_fiber	0.79100833
97	MP0005636_abnormal_mineral_homeostasis	0.79021554
98	MP0005365_abnormal_bile_salt	0.78905171
99	MP0003567_abnormal_fetal_cardiomyocyte	0.77951382
100	MP0000716_abnormal_immune_system	0.71964744

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.33931668
2	Progressive macrocephaly (HP:0004481)	3.84855326
3	Increased hepatocellular lipid droplets (HP:0006565)	3.82657873
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.82616036
5	Acute encephalopathy (HP:0006846)	3.81073784
6	Lipid accumulation in hepatocytes (HP:0006561)	3.63633451
7	Increased CSF lactate (HP:0002490)	3.59864455
8	Mitochondrial inheritance (HP:0001427)	3.55109754
9	Methylmalonic acidemia (HP:0002912)	3.53327318
10	Pancreatic cysts (HP:0001737)	3.29516717
11	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.13377910
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.08081315
13	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.07494663
14	Cerebral edema (HP:0002181)	3.02898031
15	Congenital, generalized hypertrichosis (HP:0004540)	2.94944233
16	Stomach cancer (HP:0012126)	2.87350249
17	Stomatitis (HP:0010280)	2.84119277
18	Type II lissencephaly (HP:0007260)	2.74408494
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.71842898
20	Abnormality of the labia minora (HP:0012880)	2.71148705
21	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.70314762
22	Hepatocellular necrosis (HP:0001404)	2.68341941
23	Molar tooth sign on MRI (HP:0002419)	2.67475631
24	Abnormality of midbrain morphology (HP:0002418)	2.67475631
25	Hepatic necrosis (HP:0002605)	2.62403837
26	Methylmalonic aciduria (HP:0012120)	2.61249891
27	Pancreatic fibrosis (HP:0100732)	2.58411247
28	Optic disc pallor (HP:0000543)	2.51828342
29	True hermaphroditism (HP:0010459)	2.50676818
30	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.50064490
31	Increased intramyocellular lipid droplets (HP:0012240)	2.47717849
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.42808519
33	Increased serum lactate (HP:0002151)	2.40846271
34	Aplasia/hypoplasia of the uterus (HP:0008684)	2.36864165
35	Hypoplasia of the uterus (HP:0000013)	2.35224049
36	Abnormality of vitamin B metabolism (HP:0004340)	2.32047708
37	Renal Fanconi syndrome (HP:0001994)	2.30657205
38	Abnormality of methionine metabolism (HP:0010901)	2.23748448
39	Decreased central vision (HP:0007663)	2.23426263
40	Leukodystrophy (HP:0002415)	2.23361698
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.22331851
42	Lactic acidosis (HP:0003128)	2.22125346
43	Exertional dyspnea (HP:0002875)	2.22083109
44	Abnormality of the renal cortex (HP:0011035)	2.21639626
45	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.20396029
46	Pancytopenia (HP:0001876)	2.19179714
47	Abnormality of the middle phalanges of the toes (HP:0010183)	2.18508230
48	Abnormal drinking behavior (HP:0030082)	2.17866847
49	Polydipsia (HP:0001959)	2.17866847
50	Hyperglycinuria (HP:0003108)	2.15795861
51	Abolished electroretinogram (ERG) (HP:0000550)	2.14884499
52	Conical tooth (HP:0000698)	2.13683716
53	Bile duct proliferation (HP:0001408)	2.13200200
54	Abnormal biliary tract physiology (HP:0012439)	2.13200200
55	Congenital stationary night blindness (HP:0007642)	2.12986532
56	Abnormality of glycine metabolism (HP:0010895)	2.12852653
57	Abnormality of serine family amino acid metabolism (HP:0010894)	2.12852653
58	Lethargy (HP:0001254)	2.12412711
59	Chronic hepatic failure (HP:0100626)	2.10330683
60	IgG deficiency (HP:0004315)	2.09788438
61	Abnormality of the pons (HP:0007361)	2.09581550
62	Nephronophthisis (HP:0000090)	2.09020944
63	Retrobulbar optic neuritis (HP:0100654)	2.07393422
64	Optic neuritis (HP:0100653)	2.07393422
65	Hypoplasia of the pons (HP:0012110)	2.06677856
66	Increased muscle lipid content (HP:0009058)	2.05851803
67	Ketosis (HP:0001946)	2.03354167
68	Abnormality of serum amino acid levels (HP:0003112)	2.01468151
69	Stenosis of the external auditory canal (HP:0000402)	2.00858851
70	Exercise intolerance (HP:0003546)	2.00603198
71	3-Methylglutaconic aciduria (HP:0003535)	2.00343242
72	Ketoacidosis (HP:0001993)	1.98926298
73	Chronic otitis media (HP:0000389)	1.94316228
74	Abnormality of urine glucose concentration (HP:0011016)	1.88415281
75	Glycosuria (HP:0003076)	1.88415281
76	Anorexia (HP:0002039)	1.86368166
77	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.86184938
78	Abnormality of homocysteine metabolism (HP:0010919)	1.85919582
79	Homocystinuria (HP:0002156)	1.85919582
80	Dyschromatopsia (HP:0007641)	1.84453582
81	Abnormality of the renal medulla (HP:0100957)	1.84132709
82	Bilateral microphthalmos (HP:0007633)	1.80973074
83	Large for gestational age (HP:0001520)	1.77578812
84	Chronic diarrhea (HP:0002028)	1.75683750
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.75286430
86	Dicarboxylic aciduria (HP:0003215)	1.75286430
87	Respiratory failure (HP:0002878)	1.75145406
88	Insulin-resistant diabetes mellitus (HP:0000831)	1.74675168
89	Hyperglycinemia (HP:0002154)	1.74563549
90	Abnormality of the 2nd finger (HP:0004100)	1.71089367
91	Orchitis (HP:0100796)	1.70825196
92	Polyuria (HP:0000103)	1.70626075
93	Increased corneal curvature (HP:0100692)	1.70413146
94	Keratoconus (HP:0000563)	1.70413146
95	Constricted visual fields (HP:0001133)	1.68176637
96	Respiratory difficulties (HP:0002880)	1.67010696
97	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.66482612
98	Recurrent corneal erosions (HP:0000495)	1.65963671
99	Megalencephaly (HP:0001355)	1.65945905
100	Porencephaly (HP:0002132)	1.65682968

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.93812557
2	EIF2AK3	4.85671924
3	NUAK1	3.85776529
4	ZAK	2.62386253
5	TLK1	2.57808507
6	TSSK6	2.52376846
7	PINK1	2.51236689
8	TXK	2.44826388
9	TIE1	2.43300825
10	MST4	2.34248190
11	PASK	2.12573914
12	EIF2AK1	2.09772864
13	ACVR1B	2.05460195
14	OXSR1	2.03896614
15	STK16	1.98776644
16	FRK	1.98219973
17	TAOK3	1.95952919
18	GRK1	1.79357891
19	BUB1	1.66234068
20	ADRBK2	1.66208760
21	MAP2K6	1.65966124
22	FES	1.58828962
23	EIF2AK2	1.55976402
24	FGFR2	1.55964156
25	SRPK1	1.55121650
26	MAPKAPK3	1.52026876
27	NME1	1.47305378
28	TEC	1.45889571
29	WNK4	1.36166727
30	MAP3K14	1.35670013
31	TRIM28	1.21797079
32	PHKG1	1.21652800
33	PHKG2	1.21652800
34	VRK2	1.20987784
35	NEK1	1.12377212
36	ITK	1.10742548
37	BCKDK	1.10331456
38	IRAK4	1.05356152
39	PLK3	1.04216459
40	IKBKB	1.03280290
41	IRAK1	1.02507773
42	CDK19	0.95672243
43	MKNK1	0.95242554
44	STK39	0.94239684
45	MAP4K1	0.87919010
46	KIT	0.86739276
47	EPHA3	0.82982235
48	RPS6KA5	0.78991125
49	MKNK2	0.71605065
50	VRK1	0.71590899
51	TRPM7	0.71529820
52	TGFBR1	0.70390029
53	NME2	0.69109749
54	DAPK2	0.66719122
55	WNK3	0.60601186
56	INSRR	0.60427097
57	TNIK	0.59898447
58	PRKCQ	0.59682278
59	MINK1	0.59569176
60	IKBKE	0.57672601
61	DYRK2	0.57315640
62	WNK1	0.55545772
63	ERBB3	0.53066821
64	BMPR1B	0.52226179
65	CSNK1G2	0.50734319
66	BMPR2	0.49359323
67	FLT3	0.48808637
68	LYN	0.48188541
69	FER	0.46404949
70	ADRBK1	0.44692200
71	FGFR3	0.43790731
72	FGFR1	0.43160426
73	LCK	0.40179788
74	CHUK	0.39935484
75	CLK1	0.39827362
76	DAPK1	0.38899074
77	ALK	0.38397669
78	CSF1R	0.37027704
79	IGF1R	0.36162868
80	NLK	0.34841171
81	CSNK1G1	0.33642925
82	BTK	0.31508783
83	CSNK1G3	0.31370511
84	PRKCG	0.31320331
85	PIK3CG	0.31058044
86	TNK2	0.30516001
87	MAPKAPK5	0.30216486
88	RPS6KA6	0.29420392
89	TGFBR2	0.29135897
90	OBSCN	0.26493535
91	GRK7	0.25021494
92	PLK1	0.24539302
93	SYK	0.22854283
94	CSNK2A1	0.22820899
95	ATM	0.21445902
96	MAP3K12	0.21005352
97	ABL1	0.20852407
98	GRK5	0.20717339
99	HCK	0.20353348
100	CDC7	0.20221773

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.51959762
2	Proteasome_Homo sapiens_hsa03050	3.53205587
3	Type I diabetes mellitus_Homo sapiens_hsa04940	3.08604833
4	Allograft rejection_Homo sapiens_hsa05330	2.99426172
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.90749843
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.82729439
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.56534681
8	Protein export_Homo sapiens_hsa03060	2.38633829
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.32255994
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.31373634
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.16095263
12	Ribosome_Homo sapiens_hsa03010	2.12575129
13	Butanoate metabolism_Homo sapiens_hsa00650	2.09605266
14	One carbon pool by folate_Homo sapiens_hsa00670	2.03613551
15	Parkinsons disease_Homo sapiens_hsa05012	1.89606097
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.84482287
17	Propanoate metabolism_Homo sapiens_hsa00640	1.72833792
18	Basal transcription factors_Homo sapiens_hsa03022	1.66534665
19	RNA polymerase_Homo sapiens_hsa03020	1.66061172
20	RNA degradation_Homo sapiens_hsa03018	1.53081485
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.52815927
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47659732
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.38602450
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.35657788
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.35334839
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.31171631
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.29239914
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.25601387
29	Homologous recombination_Homo sapiens_hsa03440	1.25128624
30	Mismatch repair_Homo sapiens_hsa03430	1.24496876
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.19353110
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.18273483
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13297766
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.13188425
35	Phototransduction_Homo sapiens_hsa04744	1.10228224
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.10074229
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08547242
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.07658304
39	RNA transport_Homo sapiens_hsa03013	1.07415300
40	Huntingtons disease_Homo sapiens_hsa05016	1.05530238
41	Non-homologous end-joining_Homo sapiens_hsa03450	1.05108984
42	Regulation of autophagy_Homo sapiens_hsa04140	1.03428431
43	Alzheimers disease_Homo sapiens_hsa05010	1.02228545
44	Spliceosome_Homo sapiens_hsa03040	1.00137262
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97933245
46	Purine metabolism_Homo sapiens_hsa00230	0.97518400
47	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.97328899
48	Peroxisome_Homo sapiens_hsa04146	0.96778616
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93607719
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.93071246
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.92601419
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.85609849
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.84972536
54	Base excision repair_Homo sapiens_hsa03410	0.83890689
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83189858
56	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.80691670
57	Leishmaniasis_Homo sapiens_hsa05140	0.75201774
58	Caffeine metabolism_Homo sapiens_hsa00232	0.74987606
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74825095
60	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.71993757
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70853825
62	Viral myocarditis_Homo sapiens_hsa05416	0.69228040
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69086010
64	DNA replication_Homo sapiens_hsa03030	0.68363803
65	Fanconi anemia pathway_Homo sapiens_hsa03460	0.67241861
66	Sulfur metabolism_Homo sapiens_hsa00920	0.66683357
67	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.64938509
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.63744126
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61695992
70	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.60313354
71	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.60244303
72	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.59441044
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59078964
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58072138
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55783909
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55677597
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55183117
78	Glutathione metabolism_Homo sapiens_hsa00480	0.54636785
79	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.53351760
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52029039
81	Cardiac muscle contraction_Homo sapiens_hsa04260	0.51214653
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51007186
83	Herpes simplex infection_Homo sapiens_hsa05168	0.50039289
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50029985
85	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49008545
86	Metabolic pathways_Homo sapiens_hsa01100	0.48572413
87	Ether lipid metabolism_Homo sapiens_hsa00565	0.48382319
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.46217423
89	Olfactory transduction_Homo sapiens_hsa04740	0.45602688
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45521161
91	Measles_Homo sapiens_hsa05162	0.45517001
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45307933
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44163105
94	Fatty acid degradation_Homo sapiens_hsa00071	0.43615985
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40787224
96	Retinol metabolism_Homo sapiens_hsa00830	0.40314625
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38857585
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.32469132
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32150470
100	Fatty acid elongation_Homo sapiens_hsa00062	0.31482407

RPS3AP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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