ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	8.61314566
2	adaptation of signaling pathway (GO:0023058)	6.65906112
3	synapsis (GO:0007129)	6.26850389
4	piRNA metabolic process (GO:0034587)	6.22512890
5	regulation of acrosome reaction (GO:0060046)	5.79420913
6	male meiosis (GO:0007140)	5.54402583
7	pyrimidine nucleobase catabolic process (GO:0006208)	4.96211381
8	DNA methylation involved in gamete generation (GO:0043046)	4.65220855
9	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.39012142
10	single strand break repair (GO:0000012)	4.30662701
11	inositol phosphate catabolic process (GO:0071545)	4.25712478
12	male meiosis I (GO:0007141)	4.23895041
13	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	4.23081278
14	establishment of mitochondrion localization (GO:0051654)	4.22306613
15	chromosome organization involved in meiosis (GO:0070192)	4.11033437
16	secondary metabolite biosynthetic process (GO:0044550)	4.07999386
17	positive regulation of action potential (GO:0045760)	3.97066276
18	polyol catabolic process (GO:0046174)	3.87562152
19	nucleobase catabolic process (GO:0046113)	3.84348310
20	atrial cardiac muscle cell action potential (GO:0086014)	3.77861863
21	intraciliary transport (GO:0042073)	3.77091003
22	response to methylmercury (GO:0051597)	3.77064082
23	mitochondrion transport along microtubule (GO:0047497)	3.77044517
24	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.77044517
25	glycerophospholipid catabolic process (GO:0046475)	3.74060750
26	axoneme assembly (GO:0035082)	3.65233652
27	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.62859838
28	behavioral response to nicotine (GO:0035095)	3.61165761
29	neuronal action potential propagation (GO:0019227)	3.60187885
30	negative regulation of exocytosis (GO:0045920)	3.53153582
31	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.47234280
32	meiosis I (GO:0007127)	3.38556638
33	synaptonemal complex assembly (GO:0007130)	3.36951411
34	snRNA processing (GO:0016180)	3.35867100
35	melanin biosynthetic process (GO:0042438)	3.31607691
36	nerve growth factor signaling pathway (GO:0038180)	3.27817770
37	reciprocal DNA recombination (GO:0035825)	3.26410417
38	reciprocal meiotic recombination (GO:0007131)	3.26410417
39	cilium movement (GO:0003341)	3.22872517
40	detection of calcium ion (GO:0005513)	3.19056118
41	base-excision repair, AP site formation (GO:0006285)	3.15593780
42	synaptonemal complex organization (GO:0070193)	3.11307800
43	membrane hyperpolarization (GO:0060081)	3.11169511
44	regulation of glucokinase activity (GO:0033131)	3.10638256
45	regulation of hexokinase activity (GO:1903299)	3.10638256
46	cornea development in camera-type eye (GO:0061303)	3.09993713
47	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	3.09923056
48	epithelial cilium movement (GO:0003351)	3.09470203
49	protein localization to synapse (GO:0035418)	3.07535249
50	synapse assembly (GO:0007416)	3.07413459
51	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.07066958
52	inositol phosphate dephosphorylation (GO:0046855)	3.07066958
53	regulation of androgen receptor signaling pathway (GO:0060765)	3.03835591
54	protein targeting to lysosome (GO:0006622)	3.03316247
55	establishment of protein localization to vacuole (GO:0072666)	3.03316247
56	protein targeting to vacuole (GO:0006623)	3.03316247
57	meiotic nuclear division (GO:0007126)	2.99720006
58	genitalia morphogenesis (GO:0035112)	2.99688739
59	snRNA metabolic process (GO:0016073)	2.97362424
60	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.96066319
61	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.93042115
62	phenylpropanoid metabolic process (GO:0009698)	2.89101490
63	adrenergic receptor signaling pathway (GO:0071875)	2.88144996
64	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.85799847
65	regulation of phospholipase A2 activity (GO:0032429)	2.84764507
66	neural tube formation (GO:0001841)	2.82433891
67	melanin metabolic process (GO:0006582)	2.81601793
68	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.80493918
69	photoreceptor cell maintenance (GO:0045494)	2.78820605
70	anterograde synaptic vesicle transport (GO:0048490)	2.71858307
71	membrane depolarization during action potential (GO:0086010)	2.71849276
72	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.70824156
73	ncRNA catabolic process (GO:0034661)	2.70430989
74	phosphatidylethanolamine metabolic process (GO:0046337)	2.70372022
75	positive regulation of guanylate cyclase activity (GO:0031284)	2.70203469
76	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.70193062
77	ribonucleoprotein complex disassembly (GO:0032988)	2.66522353
78	regulation of action potential (GO:0098900)	2.66459956
79	ventricular system development (GO:0021591)	2.66412627
80	negative regulation of JUN kinase activity (GO:0043508)	2.64605222
81	exploration behavior (GO:0035640)	2.63962878
82	anterograde axon cargo transport (GO:0008089)	2.62890299
83	DNA synthesis involved in DNA repair (GO:0000731)	2.61993055
84	positive regulation of amino acid transport (GO:0051957)	2.59468386
85	regulation of respiratory burst (GO:0060263)	2.58114576
86	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.57984821
87	regulation of cardiac muscle cell contraction (GO:0086004)	2.57537326
88	behavioral response to ethanol (GO:0048149)	2.57182128
89	peroxisome fission (GO:0016559)	2.56903543
90	protein K11-linked deubiquitination (GO:0035871)	2.55877899
91	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.55815925
92	synaptic transmission, cholinergic (GO:0007271)	2.54239484
93	organelle disassembly (GO:1903008)	2.52246330
94	regulation of telomere maintenance (GO:0032204)	2.50679294
95	startle response (GO:0001964)	2.46747342
96	neuronal action potential (GO:0019228)	2.46714184
97	cranial nerve development (GO:0021545)	2.45754076
98	cilium or flagellum-dependent cell motility (GO:0001539)	2.44682856
99	negative regulation of Rho protein signal transduction (GO:0035024)	2.44091648
100	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	10.2191139

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.38187016
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.80951461
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.22034923
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.19981768
5	VDR_22108803_ChIP-Seq_LS180_Human	3.04569486
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.01129257
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76363375
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.36887992
9	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.29464611
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27603634
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.24039566
12	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.17914023
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11000396
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.04472112
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.02966718
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.00067705
17	RNF2_27304074_Chip-Seq_NSC_Mouse	1.90499652
18	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.82122713
19	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.78329033
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.75607060
21	FUS_26573619_Chip-Seq_HEK293_Human	1.75035152
22	P300_19829295_ChIP-Seq_ESCs_Human	1.74282744
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67679229
24	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.66649134
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.63985708
26	STAT3_23295773_ChIP-Seq_U87_Human	1.57739303
27	AR_25329375_ChIP-Seq_VCAP_Human	1.56246528
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51867964
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.51021100
30	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.48700177
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.48665786
32	EWS_26573619_Chip-Seq_HEK293_Human	1.45205284
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44999873
34	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.43122303
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41177615
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.40955330
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40623817
38	NCOR_22424771_ChIP-Seq_293T_Human	1.39979530
39	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.38833325
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38552078
41	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.38468123
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38212664
43	RUNX2_22187159_ChIP-Seq_PCA_Human	1.37948670
44	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.36122813
45	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.31663907
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30735423
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30084214
48	TCF4_23295773_ChIP-Seq_U87_Human	1.29971532
49	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.29536941
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26127642
51	SOX9_26525672_Chip-Seq_HEART_Mouse	1.24441682
52	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.23438080
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21642347
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.21286928
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20136190
56	AR_20517297_ChIP-Seq_VCAP_Human	1.19768020
57	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19634540
58	TP53_16413492_ChIP-PET_HCT116_Human	1.18433746
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18125841
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17821445
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16739718
62	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16342132
63	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.16217763
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15564001
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.14627379
66	DROSHA_22980978_ChIP-Seq_HELA_Human	1.14063538
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13254206
68	RXR_22108803_ChIP-Seq_LS180_Human	1.11274911
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11034953
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.11034953
71	VDR_23849224_ChIP-Seq_CD4+_Human	1.10180632
72	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.10132494
73	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.09941486
74	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09727567
75	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.09465018
76	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.09391160
77	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.09268089
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09214040
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09135109
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.08830018
81	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.05749025
82	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02699046
83	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99473874
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.96194441
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96182917
86	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95542013
87	MYC_18940864_ChIP-ChIP_HL60_Human	0.94774278
88	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.94534856
89	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.94529466
90	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.94436778
91	TP53_18474530_ChIP-ChIP_U2OS_Human	0.94209536
92	JUN_21703547_ChIP-Seq_K562_Human	0.93427708
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.93351930
94	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.93263914
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.92004946
96	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.91780168
97	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.90268775
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.89914375
99	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.89885247
100	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.88547677

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	5.12967807
2	MP0008877_abnormal_DNA_methylation	4.19277540
3	MP0003787_abnormal_imprinting	3.89932406
4	MP0000569_abnormal_digit_pigmentation	3.42850205
5	MP0000372_irregular_coat_pigmentation	3.40833551
6	MP0003183_abnormal_peptide_metabolism	3.06412740
7	MP0006072_abnormal_retinal_apoptosis	2.78278243
8	MP0002653_abnormal_ependyma_morphology	2.71979338
9	MP0005075_abnormal_melanosome_morpholog	2.56098047
10	MP0003122_maternal_imprinting	2.54708328
11	MP0005551_abnormal_eye_electrophysiolog	2.51710679
12	MP0002163_abnormal_gland_morphology	2.45212480
13	MP0004043_abnormal_pH_regulation	2.35748454
14	MP0008058_abnormal_DNA_repair	2.25427868
15	MP0005408_hypopigmentation	2.21797177
16	MP0000015_abnormal_ear_pigmentation	2.20669315
17	MP0005379_endocrine/exocrine_gland_phen	2.11278839
18	MP0005253_abnormal_eye_physiology	2.03309659
19	MP0003123_paternal_imprinting	1.97035170
20	MP0002160_abnormal_reproductive_system	1.92884763
21	MP0003011_delayed_dark_adaptation	1.90090866
22	MP0001984_abnormal_olfaction	1.83659407
23	MP0002938_white_spotting	1.76061895
24	MP0009046_muscle_twitch	1.75008438
25	MP0001501_abnormal_sleep_pattern	1.74009990
26	MP0002095_abnormal_skin_pigmentation	1.64558471
27	MP0002837_dystrophic_cardiac_calcinosis	1.62549722
28	MP0001968_abnormal_touch/_nociception	1.61561533
29	MP0001919_abnormal_reproductive_system	1.60449011
30	MP0003878_abnormal_ear_physiology	1.53196817
31	MP0005377_hearing/vestibular/ear_phenot	1.53196817
32	MP0000427_abnormal_hair_cycle	1.50856187
33	MP0003121_genomic_imprinting	1.46531019
34	MP0000778_abnormal_nervous_system	1.43725612
35	MP0009745_abnormal_behavioral_response	1.43451084
36	MP0005389_reproductive_system_phenotype	1.42768775
37	MP0002272_abnormal_nervous_system	1.41286911
38	MP0008872_abnormal_physiological_respon	1.39488230
39	MP0005220_abnormal_exocrine_pancreas	1.37878311
40	MP0010234_abnormal_vibrissa_follicle	1.37493236
41	MP0003136_yellow_coat_color	1.34114352
42	MP0004142_abnormal_muscle_tone	1.32801835
43	MP0005646_abnormal_pituitary_gland	1.29407886
44	MP0002638_abnormal_pupillary_reflex	1.27387383
45	MP0004859_abnormal_synaptic_plasticity	1.26568987
46	MP0002736_abnormal_nociception_after	1.25855014
47	MP0003635_abnormal_synaptic_transmissio	1.25570860
48	MP0002090_abnormal_vision	1.22718369
49	MP0003567_abnormal_fetal_cardiomyocyte	1.21924176
50	MP0001324_abnormal_eye_pigmentation	1.21429545
51	MP0005386_behavior/neurological_phenoty	1.19552027
52	MP0004924_abnormal_behavior	1.19552027
53	MP0009840_abnormal_foam_cell	1.18408980
54	MP0003890_abnormal_embryonic-extraembry	1.15211516
55	MP0001485_abnormal_pinna_reflex	1.15012966
56	MP0002067_abnormal_sensory_capabilities	1.12095222
57	MP0003718_maternal_effect	1.08608546
58	MP0001502_abnormal_circadian_rhythm	1.07100534
59	MP0002064_seizures	1.04703530
60	MP0006276_abnormal_autonomic_nervous	1.04550110
61	MP0003943_abnormal_hepatobiliary_system	1.03439307
62	MP0000371_diluted_coat_color	1.02940073
63	MP0002063_abnormal_learning/memory/cond	1.01973162
64	MP0009780_abnormal_chondrocyte_physiolo	0.99353551
65	MP0005195_abnormal_posterior_eye	0.98776950
66	MP0005248_abnormal_Harderian_gland	0.98583633
67	MP0002210_abnormal_sex_determination	0.97854168
68	MP0003698_abnormal_male_reproductive	0.96933711
69	MP0005365_abnormal_bile_salt	0.96586268
70	MP0005174_abnormal_tail_pigmentation	0.96065032
71	MP0002557_abnormal_social/conspecific_i	0.93533235
72	MP0002572_abnormal_emotion/affect_behav	0.93495670
73	MP0010678_abnormal_skin_adnexa	0.93168240
74	MP0002332_abnormal_exercise_endurance	0.91919596
75	MP0005167_abnormal_blood-brain_barrier	0.91088199
76	MP0005391_vision/eye_phenotype	0.90722468
77	MP0000653_abnormal_sex_gland	0.89140093
78	MP0005171_absent_coat_pigmentation	0.88879486
79	MP0001440_abnormal_grooming_behavior	0.88650278
80	MP0001929_abnormal_gametogenesis	0.88274979
81	MP0002229_neurodegeneration	0.87216068
82	MP0001145_abnormal_male_reproductive	0.87078051
83	MP0004270_analgesia	0.87010284
84	MP0004811_abnormal_neuron_physiology	0.84795912
85	MP0006035_abnormal_mitochondrial_morpho	0.84506681
86	MP0003137_abnormal_impulse_conducting	0.81567340
87	MP0002735_abnormal_chemical_nociception	0.80792257
88	MP0001986_abnormal_taste_sensitivity	0.79224551
89	MP0000631_abnormal_neuroendocrine_gland	0.78817530
90	MP0005084_abnormal_gallbladder_morpholo	0.78444652
91	MP0001486_abnormal_startle_reflex	0.78336527
92	MP0006292_abnormal_olfactory_placode	0.78148081
93	MP0003880_abnormal_central_pattern	0.77288429
94	MP0002882_abnormal_neuron_morphology	0.76984160
95	MP0004145_abnormal_muscle_electrophysio	0.76955047
96	MP0001970_abnormal_pain_threshold	0.76428475
97	MP0003786_premature_aging	0.74546499
98	MP0000955_abnormal_spinal_cord	0.73857843
99	MP0002282_abnormal_trachea_morphology	0.70516392
100	MP0003119_abnormal_digestive_system	0.68891806

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	5.77573573
2	Pendular nystagmus (HP:0012043)	4.15541638
3	Volvulus (HP:0002580)	4.06526125
4	3-Methylglutaconic aciduria (HP:0003535)	4.06134056
5	Carpal bone hypoplasia (HP:0001498)	3.99941800
6	Hip dysplasia (HP:0001385)	3.81673162
7	J-shaped sella turcica (HP:0002680)	3.47999300
8	Pancreatic cysts (HP:0001737)	3.46385635
9	Broad alveolar ridges (HP:0000187)	3.28264505
10	Focal seizures (HP:0007359)	3.23021861
11	Abnormality of the renal cortex (HP:0011035)	3.19935196
12	Abnormal ciliary motility (HP:0012262)	3.14996339
13	Renal cortical cysts (HP:0000803)	3.11430771
14	Generalized hypopigmentation (HP:0007513)	2.93994940
15	Abnormality of the pancreatic islet cells (HP:0006476)	2.93866314
16	Abnormality of endocrine pancreas physiology (HP:0012093)	2.93866314
17	Severe visual impairment (HP:0001141)	2.92437316
18	Diastasis recti (HP:0001540)	2.91275516
19	Febrile seizures (HP:0002373)	2.91263470
20	Type II lissencephaly (HP:0007260)	2.88518127
21	True hermaphroditism (HP:0010459)	2.84515546
22	Polyphagia (HP:0002591)	2.84057712
23	Fibular aplasia (HP:0002990)	2.83591908
24	Abnormal respiratory motile cilium physiology (HP:0012261)	2.82981147
25	Hypomagnesemia (HP:0002917)	2.81054860
26	Iris hypopigmentation (HP:0007730)	2.80836302
27	Ketoacidosis (HP:0001993)	2.78370338
28	Pancreatic fibrosis (HP:0100732)	2.76669018
29	Oligodactyly (hands) (HP:0001180)	2.74087583
30	Atonic seizures (HP:0010819)	2.70173986
31	Abnormality of macular pigmentation (HP:0008002)	2.69561127
32	Rhinitis (HP:0012384)	2.63643797
33	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.63595223
34	Abnormal respiratory motile cilium morphology (HP:0005938)	2.63037566
35	Abnormal respiratory epithelium morphology (HP:0012253)	2.63037566
36	Retinal dysplasia (HP:0007973)	2.58727000
37	Hypoalbuminemia (HP:0003073)	2.57893909
38	Abnormal albumin level (HP:0012116)	2.57893909
39	Nephrogenic diabetes insipidus (HP:0009806)	2.57128904
40	Tetany (HP:0001281)	2.52074047
41	Lissencephaly (HP:0001339)	2.50511059
42	Molar tooth sign on MRI (HP:0002419)	2.46508027
43	Abnormality of midbrain morphology (HP:0002418)	2.46508027
44	Chronic hepatic failure (HP:0100626)	2.44452327
45	Polydipsia (HP:0001959)	2.43640450
46	Abnormal drinking behavior (HP:0030082)	2.43640450
47	Abnormality of the labia minora (HP:0012880)	2.42363566
48	Occipital encephalocele (HP:0002085)	2.42100865
49	Methylmalonic aciduria (HP:0012120)	2.38384052
50	Hyperglycinemia (HP:0002154)	2.34965354
51	Fibular hypoplasia (HP:0003038)	2.34941377
52	Aortic regurgitation (HP:0001659)	2.30114925
53	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.29105359
54	Megalencephaly (HP:0001355)	2.28871198
55	Hemiparesis (HP:0001269)	2.27461203
56	Ocular albinism (HP:0001107)	2.24960162
57	Delayed CNS myelination (HP:0002188)	2.24870700
58	Abnormality of magnesium homeostasis (HP:0004921)	2.24515806
59	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24234525
60	Albinism (HP:0001022)	2.23365471
61	Abolished electroretinogram (ERG) (HP:0000550)	2.14909153
62	Nephronophthisis (HP:0000090)	2.14079294
63	Intestinal atresia (HP:0011100)	2.13201387
64	Abnormal urine output (HP:0012590)	2.12139114
65	Generalized hypopigmentation of hair (HP:0011358)	2.10820961
66	Cerebellar dysplasia (HP:0007033)	2.08850786
67	Conjugated hyperbilirubinemia (HP:0002908)	2.07707693
68	Abnormality of glycolipid metabolism (HP:0010969)	2.07070400
69	Abnormality of liposaccharide metabolism (HP:0010968)	2.07070400
70	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.07070400
71	Postaxial foot polydactyly (HP:0001830)	2.06047131
72	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.05839443
73	Congenital hepatic fibrosis (HP:0002612)	2.04266066
74	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.03967066
75	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.03967066
76	Potter facies (HP:0002009)	2.03938365
77	Facial shape deformation (HP:0011334)	2.03938365
78	Broad ribs (HP:0000885)	2.03916394
79	Bifid tongue (HP:0010297)	2.03223886
80	Pancreatic islet-cell hyperplasia (HP:0004510)	2.03068220
81	Gait imbalance (HP:0002141)	2.02960373
82	Poor suck (HP:0002033)	2.01379450
83	Abnormality of the renal medulla (HP:0100957)	2.00554938
84	Abnormality of the alveolar ridges (HP:0006477)	1.97090110
85	Hypoplastic pelvis (HP:0008839)	1.94823335
86	Abnormal hair laboratory examination (HP:0003328)	1.94802399
87	Tubular atrophy (HP:0000092)	1.94313738
88	Abnormality of renal excretion (HP:0011036)	1.93210769
89	Oligodactyly (HP:0012165)	1.91291105
90	Failure to thrive in infancy (HP:0001531)	1.90585596
91	Constricted visual fields (HP:0001133)	1.89724477
92	Astigmatism (HP:0000483)	1.89247472
93	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.87983851
94	Dialeptic seizures (HP:0011146)	1.86961490
95	Cystic liver disease (HP:0006706)	1.85825210
96	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83251554
97	Brittle hair (HP:0002299)	1.82350269
98	Anterior segment dysgenesis (HP:0007700)	1.79611530
99	Congenital primary aphakia (HP:0007707)	1.78105850
100	Vaginal atresia (HP:0000148)	1.77735856

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.45121419
2	CAMKK2	3.62313289
3	PNCK	3.42190123
4	NUAK1	3.42053065
5	LATS1	3.05795074
6	SRPK1	2.99528920
7	MAP3K12	2.97907957
8	NTRK3	2.51503016
9	INSRR	2.44260092
10	DYRK3	2.27126026
11	BCKDK	2.17133737
12	MAP2K6	2.14679599
13	STK16	2.13368036
14	FRK	2.07735565
15	BCR	1.93745223
16	MAP3K4	1.93489341
17	RPS6KA4	1.83555446
18	CAMK1	1.77031262
19	EPHA4	1.72638661
20	DYRK2	1.72159135
21	PINK1	1.70334209
22	MAP2K7	1.60104093
23	TRIM28	1.58588334
24	BMPR1B	1.58463412
25	SIK3	1.53354898
26	PAK3	1.46549916
27	MAP3K5	1.43773303
28	MAP4K2	1.39502410
29	CAMKK1	1.38386009
30	EPHA3	1.37748156
31	FER	1.33208391
32	CDK3	1.20976301
33	MINK1	1.20206058
34	MAP3K6	1.19676147
35	CAMK1G	1.19213188
36	MAP3K11	1.18900550
37	ACVR1B	1.13340558
38	MAP2K4	1.03428106
39	WNK3	0.97148773
40	CSNK1G3	0.93742694
41	CASK	0.93292912
42	CAMK4	0.89318357
43	TYRO3	0.87625428
44	CSNK1G2	0.87046720
45	MAPK13	0.86562073
46	PIM2	0.86223899
47	CSNK1G1	0.84244680
48	PASK	0.83808395
49	RPS6KA5	0.82771854
50	EIF2AK3	0.82753951
51	RET	0.81565196
52	CSNK1A1L	0.80834892
53	STK38	0.79567804
54	MST4	0.75479656
55	DYRK1A	0.73364874
56	PRKCQ	0.72817597
57	PRKCG	0.69332292
58	CDK19	0.69140518
59	VRK1	0.68199775
60	TEC	0.59964921
61	SIK2	0.58547646
62	PLK2	0.56219205
63	PRKCE	0.55998513
64	ADRBK2	0.55636898
65	BRSK2	0.55166009
66	PDK2	0.54396961
67	YES1	0.53091364
68	CAMK2A	0.52152025
69	PTK2B	0.51620052
70	CSNK1A1	0.51108362
71	MKNK2	0.50647868
72	GRK7	0.50447931
73	LIMK1	0.50068617
74	GRK5	0.49839518
75	GSK3A	0.49126297
76	MARK3	0.48913124
77	CDK5	0.48788273
78	PRKCZ	0.47141119
79	SCYL2	0.47089164
80	RAF1	0.46789991
81	OXSR1	0.42003260
82	PKN1	0.41889043
83	MAPK15	0.41255372
84	ABL1	0.40826969
85	ATM	0.38296855
86	ROCK1	0.34218284
87	CCNB1	0.33532586
88	IRAK1	0.30511005
89	ZAK	0.29532726
90	CLK1	0.29074464
91	BUB1	0.29003763
92	PTK6	0.27518709
93	ADRBK1	0.27432208
94	DAPK1	0.24573542
95	SGK1	0.24226204
96	BRD4	0.24154311
97	MET	0.21882694
98	PRKCI	0.21699710
99	PRKD2	0.21452474
100	PIK3CA	0.20149712

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.39543694
2	Phototransduction_Homo sapiens_hsa04744	3.49165445
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.73204221
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.51215398
5	Butanoate metabolism_Homo sapiens_hsa00650	2.34721268
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.20187471
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.17505357
8	Nicotine addiction_Homo sapiens_hsa05033	2.08816775
9	Steroid biosynthesis_Homo sapiens_hsa00100	1.94331727
10	Caffeine metabolism_Homo sapiens_hsa00232	1.82714826
11	RNA degradation_Homo sapiens_hsa03018	1.81860443
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.79940860
13	Propanoate metabolism_Homo sapiens_hsa00640	1.76764905
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.76510263
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75705610
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73513516
17	Renin-angiotensin system_Homo sapiens_hsa04614	1.67617419
18	Retinol metabolism_Homo sapiens_hsa00830	1.65608497
19	Amphetamine addiction_Homo sapiens_hsa05031	1.54443837
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.51939469
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.48279826
22	Dopaminergic synapse_Homo sapiens_hsa04728	1.45685700
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.45516314
24	Parkinsons disease_Homo sapiens_hsa05012	1.45026465
25	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.42687133
26	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.42330049
27	Protein export_Homo sapiens_hsa03060	1.39783147
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36153529
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32764886
30	Huntingtons disease_Homo sapiens_hsa05016	1.25984703
31	Taste transduction_Homo sapiens_hsa04742	1.25679178
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.24140272
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.23552479
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.23070386
35	Cocaine addiction_Homo sapiens_hsa05030	1.22857186
36	Morphine addiction_Homo sapiens_hsa05032	1.21959484
37	Insulin secretion_Homo sapiens_hsa04911	1.16319270
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.14661463
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.13246172
40	Circadian entrainment_Homo sapiens_hsa04713	1.10700938
41	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03092331
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02933655
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.98269526
44	RNA polymerase_Homo sapiens_hsa03020	0.97344629
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.96753681
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.93258577
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.92503588
48	Olfactory transduction_Homo sapiens_hsa04740	0.92408995
49	GABAergic synapse_Homo sapiens_hsa04727	0.90285431
50	Regulation of autophagy_Homo sapiens_hsa04140	0.88658231
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.87014057
52	Axon guidance_Homo sapiens_hsa04360	0.85182547
53	Sulfur metabolism_Homo sapiens_hsa00920	0.84879720
54	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.81448316
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.79284940
56	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.79167387
57	Homologous recombination_Homo sapiens_hsa03440	0.77678292
58	Circadian rhythm_Homo sapiens_hsa04710	0.75501557
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74990043
60	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.74771080
61	Proteasome_Homo sapiens_hsa03050	0.73389432
62	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.71628369
63	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71300709
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70639979
65	Oocyte meiosis_Homo sapiens_hsa04114	0.69158229
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.68940850
67	Nitrogen metabolism_Homo sapiens_hsa00910	0.68555916
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67821955
69	Cholinergic synapse_Homo sapiens_hsa04725	0.66080374
70	Fatty acid elongation_Homo sapiens_hsa00062	0.62667953
71	Fatty acid degradation_Homo sapiens_hsa00071	0.62400302
72	Metabolic pathways_Homo sapiens_hsa01100	0.61607692
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61030268
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.60954317
75	Renin secretion_Homo sapiens_hsa04924	0.59694626
76	Peroxisome_Homo sapiens_hsa04146	0.59428017
77	Type II diabetes mellitus_Homo sapiens_hsa04930	0.58415643
78	cAMP signaling pathway_Homo sapiens_hsa04024	0.58364446
79	Tyrosine metabolism_Homo sapiens_hsa00350	0.58214831
80	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.55066403
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.55045765
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54348934
83	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.53933662
84	Serotonergic synapse_Homo sapiens_hsa04726	0.53380893
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.53304055
86	Basal transcription factors_Homo sapiens_hsa03022	0.49070120
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48108229
88	Salivary secretion_Homo sapiens_hsa04970	0.45824746
89	Cardiac muscle contraction_Homo sapiens_hsa04260	0.45583729
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.43693641
91	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42557150
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.42312353
93	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41345871
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41300711
95	ABC transporters_Homo sapiens_hsa02010	0.41146711
96	Lysosome_Homo sapiens_hsa04142	0.40732770
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.40327415
98	Hippo signaling pathway_Homo sapiens_hsa04390	0.40280104
99	Alzheimers disease_Homo sapiens_hsa05010	0.40261841
100	Purine metabolism_Homo sapiens_hsa00230	0.36611449

RPS3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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