ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.67485171
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.50416388
3	cytidine deamination (GO:0009972)	4.40890263
4	cytidine metabolic process (GO:0046087)	4.40890263
5	cytidine catabolic process (GO:0006216)	4.40890263
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.26777734
7	behavioral response to nicotine (GO:0035095)	4.09996372
8	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.87540022
9	positive regulation of defense response to virus by host (GO:0002230)	3.76651974
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.73318901
11	ATP synthesis coupled proton transport (GO:0015986)	3.73318901
12	positive regulation of prostaglandin secretion (GO:0032308)	3.61083792
13	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.59259975
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.46431572
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.46431572
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.39415113
17	fucose catabolic process (GO:0019317)	3.37016115
18	L-fucose metabolic process (GO:0042354)	3.37016115
19	L-fucose catabolic process (GO:0042355)	3.37016115
20	regulation of memory T cell differentiation (GO:0043380)	3.35866562
21	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.30712051
22	regulation of isotype switching to IgG isotypes (GO:0048302)	3.27009569
23	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.26935729
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.20971852
25	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.20788480
26	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.15529313
27	ribosomal small subunit assembly (GO:0000028)	3.14994785
28	rRNA catabolic process (GO:0016075)	3.11585482
29	regulation of T cell mediated cytotoxicity (GO:0001914)	3.09698753
30	tachykinin receptor signaling pathway (GO:0007217)	3.07287581
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.04559235
32	negative regulation of heart rate (GO:0010459)	3.02073975
33	branched-chain amino acid catabolic process (GO:0009083)	3.00163789
34	proteasome assembly (GO:0043248)	3.00023774
35	positive regulation of interleukin-17 production (GO:0032740)	2.94095178
36	piRNA metabolic process (GO:0034587)	2.94006737
37	GTP biosynthetic process (GO:0006183)	2.93997721
38	S-adenosylmethionine metabolic process (GO:0046500)	2.92315359
39	protein neddylation (GO:0045116)	2.90767711
40	positive regulation of fatty acid transport (GO:2000193)	2.89950762
41	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88785753
42	NADH dehydrogenase complex assembly (GO:0010257)	2.88785753
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88785753
44	rRNA modification (GO:0000154)	2.87999502
45	regulation of cellular amino acid metabolic process (GO:0006521)	2.86236141
46	regulation of regulatory T cell differentiation (GO:0045589)	2.84585988
47	platelet dense granule organization (GO:0060155)	2.82659479
48	protein complex biogenesis (GO:0070271)	2.81752567
49	positive regulation of T-helper 1 type immune response (GO:0002827)	2.79423457
50	pseudouridine synthesis (GO:0001522)	2.78520857
51	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78253369
52	regulation of activation of Janus kinase activity (GO:0010533)	2.76958322
53	response to interferon-beta (GO:0035456)	2.76596531
54	metallo-sulfur cluster assembly (GO:0031163)	2.76444817
55	iron-sulfur cluster assembly (GO:0016226)	2.76444817
56	cellular response to exogenous dsRNA (GO:0071360)	2.76233722
57	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.73799248
58	branched-chain amino acid metabolic process (GO:0009081)	2.72446245
59	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.70320251
60	regulation of prostaglandin secretion (GO:0032306)	2.69668217
61	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.67589373
62	negative regulation of telomere maintenance (GO:0032205)	2.65672271
63	tRNA processing (GO:0008033)	2.63683566
64	positive regulation of action potential (GO:0045760)	2.63357154
65	indolalkylamine metabolic process (GO:0006586)	2.62879816
66	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.62302949
67	positive regulation of icosanoid secretion (GO:0032305)	2.62286305
68	mannosylation (GO:0097502)	2.61868412
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.61272276
70	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.61270316
71	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.60874764
72	termination of RNA polymerase III transcription (GO:0006386)	2.60874764
73	regulation of chronic inflammatory response (GO:0002676)	2.60233434
74	mast cell degranulation (GO:0043303)	2.58621257
75	mast cell activation involved in immune response (GO:0002279)	2.58621257
76	electron transport chain (GO:0022900)	2.58456486
77	cellular response to interleukin-15 (GO:0071350)	2.58270819
78	protein polyglutamylation (GO:0018095)	2.57113290
79	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.56347030
80	mitochondrial respiratory chain complex assembly (GO:0033108)	2.55269851
81	adaptation of signaling pathway (GO:0023058)	2.55238771
82	regulation of immunoglobulin secretion (GO:0051023)	2.54938666
83	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.53632373
84	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.53632373
85	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.53632373
86	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.52773320
87	respiratory chain complex IV assembly (GO:0008535)	2.52032608
88	respiratory electron transport chain (GO:0022904)	2.51822716
89	regulation of defense response to virus by host (GO:0050691)	2.51355931
90	ATP biosynthetic process (GO:0006754)	2.50937925
91	cellular response to interferon-beta (GO:0035458)	2.50260398
92	positive regulation of cell killing (GO:0031343)	2.49887385
93	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.49283070
94	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.49283070
95	interferon-gamma production (GO:0032609)	2.49123615
96	negative regulation of mast cell activation (GO:0033004)	2.48918396
97	positive regulation of activated T cell proliferation (GO:0042104)	2.48209224
98	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.47223800
99	regulation of action potential (GO:0098900)	2.47114788
100	sulfation (GO:0051923)	2.46182689

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.92072466
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.70872774
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.49777970
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.38193944
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09378091
6	VDR_22108803_ChIP-Seq_LS180_Human	3.09019701
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84116363
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.81765664
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.76983883
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.73141948
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.64424391
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.62763675
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.62523469
14	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.49262789
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.39854655
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.37435733
17	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.15986721
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.14625327
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.13886631
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07390550
21	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04071877
22	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.01078015
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99736594
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.90127400
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.86019538
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.83159501
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.75493060
28	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.73508032
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.69211577
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.66692883
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66579023
32	GATA3_26560356_Chip-Seq_TH2_Human	1.57374626
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55962415
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53241347
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52399054
36	EWS_26573619_Chip-Seq_HEK293_Human	1.46750499
37	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.44880627
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.44823176
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.44285327
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.44285327
41	AR_20517297_ChIP-Seq_VCAP_Human	1.42706972
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.41346112
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39881087
44	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.39081754
45	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.36656618
46	FUS_26573619_Chip-Seq_HEK293_Human	1.36612382
47	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.33246872
48	MYB_26560356_Chip-Seq_TH2_Human	1.31512732
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28405167
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27454966
51	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26104283
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25147553
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22591379
54	NCOR_22424771_ChIP-Seq_293T_Human	1.21625992
55	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.20283868
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17121415
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16501379
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16254382
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16254382
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16221472
61	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.15752089
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.14957113
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.14957113
64	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14549856
65	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14319549
66	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13823322
67	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.13433560
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12208519
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12143659
70	CIITA_25753668_ChIP-Seq_RAJI_Human	1.11921437
71	GATA3_27048872_Chip-Seq_THYMUS_Human	1.09066313
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07814470
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.07449507
74	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06570409
75	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06372934
76	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.05877002
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05611320
78	ERA_21632823_ChIP-Seq_H3396_Human	1.05217619
79	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02886282
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.02555577
81	GABP_19822575_ChIP-Seq_HepG2_Human	1.01211539
82	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.01127481
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00880632
84	P300_19829295_ChIP-Seq_ESCs_Human	0.99899249
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98860668
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98520971
87	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.97368289
88	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97357347
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96890791
90	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.96846702
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.96805311
92	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.96042389
93	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.95828602
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95701874
95	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95554900
96	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.94842741
97	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.93721442
98	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.93388467
99	TTF2_22483619_ChIP-Seq_HELA_Human	0.92756582
100	GBX2_23144817_ChIP-Seq_PC3_Human	0.91917590

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.27967027
2	MP0002102_abnormal_ear_morphology	2.77176845
3	MP0001835_abnormal_antigen_presentation	2.64686567
4	MP0002138_abnormal_hepatobiliary_system	2.54591037
5	MP0003195_calcinosis	2.50349457
6	MP0008877_abnormal_DNA_methylation	2.45993447
7	MP0008875_abnormal_xenobiotic_pharmacok	2.27569400
8	MP0004885_abnormal_endolymph	2.15832276
9	MP0001968_abnormal_touch/_nociception	2.11331179
10	MP0004147_increased_porphyrin_level	2.06910775
11	MP0002148_abnormal_hypersensitivity_rea	1.97094469
12	MP0008872_abnormal_physiological_respon	1.94168324
13	MP0000685_abnormal_immune_system	1.93744457
14	MP0005646_abnormal_pituitary_gland	1.93465936
15	MP0001986_abnormal_taste_sensitivity	1.92382218
16	MP0002876_abnormal_thyroid_physiology	1.92159024
17	MP0006072_abnormal_retinal_apoptosis	1.91596602
18	MP0010386_abnormal_urinary_bladder	1.89152096
19	MP0005075_abnormal_melanosome_morpholog	1.75516945
20	MP0001800_abnormal_humoral_immune	1.75077291
21	MP0002736_abnormal_nociception_after	1.74865893
22	MP0005645_abnormal_hypothalamus_physiol	1.70495014
23	MP0001790_abnormal_immune_system	1.70442199
24	MP0005387_immune_system_phenotype	1.70442199
25	MP0008058_abnormal_DNA_repair	1.66390293
26	MP0006292_abnormal_olfactory_placode	1.65588054
27	MP0009785_altered_susceptibility_to	1.64313455
28	MP0005000_abnormal_immune_tolerance	1.63801800
29	MP0005084_abnormal_gallbladder_morpholo	1.63575938
30	MP0000372_irregular_coat_pigmentation	1.59711651
31	MP0005551_abnormal_eye_electrophysiolog	1.57450687
32	MP0002163_abnormal_gland_morphology	1.51300097
33	MP0002723_abnormal_immune_serum	1.49679224
34	MP0003880_abnormal_central_pattern	1.47468505
35	MP0003806_abnormal_nucleotide_metabolis	1.44228941
36	MP0002420_abnormal_adaptive_immunity	1.42989318
37	MP0001873_stomach_inflammation	1.42281335
38	MP0003763_abnormal_thymus_physiology	1.41258117
39	MP0001819_abnormal_immune_cell	1.40926030
40	MP0003646_muscle_fatigue	1.40544243
41	MP0003787_abnormal_imprinting	1.39974042
42	MP0003866_abnormal_defecation	1.37734701
43	MP0001501_abnormal_sleep_pattern	1.32129379
44	MP0005083_abnormal_biliary_tract	1.30375588
45	MP0005379_endocrine/exocrine_gland_phen	1.28616728
46	MP0009764_decreased_sensitivity_to	1.27686232
47	MP0002452_abnormal_antigen_presenting	1.27679935
48	MP0004142_abnormal_muscle_tone	1.24663391
49	MP0001764_abnormal_homeostasis	1.24181513
50	MP0003718_maternal_effect	1.23727231
51	MP0005167_abnormal_blood-brain_barrier	1.23527414
52	MP0003252_abnormal_bile_duct	1.23009853
53	MP0003786_premature_aging	1.20712786
54	MP0009333_abnormal_splenocyte_physiolog	1.20559421
55	MP0004145_abnormal_muscle_electrophysio	1.16930175
56	MP0005253_abnormal_eye_physiology	1.16001639
57	MP0005377_hearing/vestibular/ear_phenot	1.13782860
58	MP0003878_abnormal_ear_physiology	1.13782860
59	MP0001905_abnormal_dopamine_level	1.12649335
60	MP0005389_reproductive_system_phenotype	1.09618121
61	MP0005025_abnormal_response_to	1.07361382
62	MP0005410_abnormal_fertilization	1.06366510
63	MP0000689_abnormal_spleen_morphology	1.05307853
64	MP0002166_altered_tumor_susceptibility	1.02689293
65	MP0001984_abnormal_olfaction	1.01916959
66	MP0001919_abnormal_reproductive_system	1.01658269
67	MP0002653_abnormal_ependyma_morphology	1.01095595
68	MP0010155_abnormal_intestine_physiology	1.00889704
69	MP0006035_abnormal_mitochondrial_morpho	1.00310388
70	MP0000716_abnormal_immune_system	0.99868620
71	MP0002234_abnormal_pharynx_morphology	0.99554577
72	MP0004043_abnormal_pH_regulation	0.98421720
73	MP0002272_abnormal_nervous_system	0.98080726
74	MP0003436_decreased_susceptibility_to	0.98008739
75	MP0006036_abnormal_mitochondrial_physio	0.97883638
76	MP0002006_tumorigenesis	0.97197012
77	MP0002398_abnormal_bone_marrow	0.96681754
78	MP0006276_abnormal_autonomic_nervous	0.95964859
79	MP0002405_respiratory_system_inflammati	0.95445660
80	MP0008775_abnormal_heart_ventricle	0.94225911
81	MP0004742_abnormal_vestibular_system	0.91066588
82	MP0002160_abnormal_reproductive_system	0.91061553
83	MP0001845_abnormal_inflammatory_respons	0.90348254
84	MP0003724_increased_susceptibility_to	0.89517034
85	MP0002837_dystrophic_cardiac_calcinosis	0.88602299
86	MP0009745_abnormal_behavioral_response	0.87531553
87	MP0001970_abnormal_pain_threshold	0.86054630
88	MP0008995_early_reproductive_senescence	0.85043570
89	MP0003567_abnormal_fetal_cardiomyocyte	0.83441017
90	MP0002733_abnormal_thermal_nociception	0.81613735
91	MP0003638_abnormal_response/metabolism_	0.80280681
92	MP0000613_abnormal_salivary_gland	0.79972440
93	MP0002722_abnormal_immune_system	0.79401605
94	MP0000230_abnormal_systemic_arterial	0.79291235
95	MP0010368_abnormal_lymphatic_system	0.78197142
96	MP0002429_abnormal_blood_cell	0.76825637
97	MP0002419_abnormal_innate_immunity	0.75910475
98	MP0002693_abnormal_pancreas_physiology	0.75382217
99	MP0005085_abnormal_gallbladder_physiolo	0.72360128
100	MP0005636_abnormal_mineral_homeostasis	0.72307439

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.58771019
2	Acute necrotizing encephalopathy (HP:0006965)	3.46872431
3	3-Methylglutaconic aciduria (HP:0003535)	3.45653284
4	Mitochondrial inheritance (HP:0001427)	3.40386250
5	IgG deficiency (HP:0004315)	3.32455921
6	Type II lissencephaly (HP:0007260)	3.28480790
7	Increased CSF lactate (HP:0002490)	3.26478275
8	Elevated erythrocyte sedimentation rate (HP:0003565)	3.16316287
9	Acute encephalopathy (HP:0006846)	3.12521946
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.12303837
11	Increased hepatocellular lipid droplets (HP:0006565)	3.12264534
12	Hepatocellular necrosis (HP:0001404)	3.06205237
13	Congenital stationary night blindness (HP:0007642)	3.05022222
14	Abnormality of the renal cortex (HP:0011035)	3.01515625
15	Stomatitis (HP:0010280)	2.98032536
16	Abolished electroretinogram (ERG) (HP:0000550)	2.95277509
17	Progressive macrocephaly (HP:0004481)	2.91873666
18	Hepatic necrosis (HP:0002605)	2.91731684
19	Attenuation of retinal blood vessels (HP:0007843)	2.84698995
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.84278954
21	Lipid accumulation in hepatocytes (HP:0006561)	2.84099499
22	Abnormality of midbrain morphology (HP:0002418)	2.80381884
23	Molar tooth sign on MRI (HP:0002419)	2.80381884
24	Methylmalonic acidemia (HP:0002912)	2.68049229
25	Nephronophthisis (HP:0000090)	2.66943542
26	Renal cortical cysts (HP:0000803)	2.66150538
27	Pancreatic fibrosis (HP:0100732)	2.65242617
28	Panhypogammaglobulinemia (HP:0003139)	2.59501946
29	Increased serum lactate (HP:0002151)	2.54460292
30	Myositis (HP:0100614)	2.52899207
31	Abnormality of T cells (HP:0002843)	2.51095350
32	Abnormality of T cell physiology (HP:0011840)	2.49402653
33	Retrobulbar optic neuritis (HP:0100654)	2.48618510
34	Optic neuritis (HP:0100653)	2.48618510
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.48043806
36	Severe combined immunodeficiency (HP:0004430)	2.47742797
37	Cerebral edema (HP:0002181)	2.46184721
38	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.46096394
39	Increased intramyocellular lipid droplets (HP:0012240)	2.45740608
40	Optic disc pallor (HP:0000543)	2.44427994
41	Cerebellar dysplasia (HP:0007033)	2.43103914
42	Hyperglycinemia (HP:0002154)	2.42622252
43	Methylmalonic aciduria (HP:0012120)	2.42258274
44	True hermaphroditism (HP:0010459)	2.38594749
45	Increased IgM level (HP:0003496)	2.38130608
46	Abnormality of T cell number (HP:0011839)	2.37232249
47	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.37142777
48	Renal Fanconi syndrome (HP:0001994)	2.36313824
49	Abnormality of the renal medulla (HP:0100957)	2.35980630
50	Decreased central vision (HP:0007663)	2.35520873
51	Abnormality of the prostate (HP:0008775)	2.34391902
52	Hypoproteinemia (HP:0003075)	2.31877589
53	Lactic acidosis (HP:0003128)	2.28577477
54	Encephalitis (HP:0002383)	2.23657519
55	Abnormality of the pons (HP:0007361)	2.22673502
56	T lymphocytopenia (HP:0005403)	2.22375032
57	Orchitis (HP:0100796)	2.21251791
58	Abnormality of eosinophils (HP:0001879)	2.20861508
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.19977841
60	Thyroiditis (HP:0100646)	2.17088194
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11769394
62	Colon cancer (HP:0003003)	2.09719268
63	Increased corneal curvature (HP:0100692)	2.09367642
64	Keratoconus (HP:0000563)	2.09367642
65	Abnormality of B cell number (HP:0010975)	2.08720945
66	Aplastic anemia (HP:0001915)	2.08402720
67	Lethargy (HP:0001254)	2.04735796
68	Pendular nystagmus (HP:0012043)	2.01644147
69	Ketosis (HP:0001946)	2.00066799
70	Increased muscle lipid content (HP:0009058)	1.97273834
71	Exertional dyspnea (HP:0002875)	1.95996527
72	Pancytopenia (HP:0001876)	1.95947159
73	Abnormality of glycine metabolism (HP:0010895)	1.94665348
74	Abnormality of serine family amino acid metabolism (HP:0010894)	1.94665348
75	Opisthotonus (HP:0002179)	1.94645790
76	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.94306427
77	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.94306427
78	Constricted visual fields (HP:0001133)	1.93653869
79	Chronic hepatic failure (HP:0100626)	1.92836460
80	Eosinophilia (HP:0001880)	1.92198818
81	Hypoplasia of the pons (HP:0012110)	1.91023483
82	Autoimmune hemolytic anemia (HP:0001890)	1.90025743
83	Polydipsia (HP:0001959)	1.87662490
84	Abnormal drinking behavior (HP:0030082)	1.87662490
85	Keratoconjunctivitis (HP:0001096)	1.86898108
86	Autoimmune thrombocytopenia (HP:0001973)	1.86829678
87	Abnormal number of erythroid precursors (HP:0012131)	1.85945704
88	Abnormality of alanine metabolism (HP:0010916)	1.85202680
89	Hyperalaninemia (HP:0003348)	1.85202680
90	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85202680
91	Cerebral palsy (HP:0100021)	1.83832878
92	Chronic diarrhea (HP:0002028)	1.83238287
93	Prostate neoplasm (HP:0100787)	1.81638463
94	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.80919477
95	Dicarboxylic aciduria (HP:0003215)	1.80919477
96	Delayed CNS myelination (HP:0002188)	1.80536341
97	Congenital, generalized hypertrichosis (HP:0004540)	1.80255689
98	Large for gestational age (HP:0001520)	1.77268083
99	Combined immunodeficiency (HP:0005387)	1.76227577
100	Hyperglycinuria (HP:0003108)	1.75307047

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.71373264
2	MAP4K2	3.48043225
3	BCKDK	3.46031464
4	TIE1	3.28591388
5	TLK1	3.17991034
6	ZAK	2.90043872
7	NUAK1	2.69563522
8	VRK2	2.61131215
9	ADRBK2	2.58632681
10	FRK	2.09734145
11	SRPK1	2.03687823
12	TEC	1.99186281
13	KDR	1.92744776
14	TAOK3	1.89863222
15	GRK1	1.87147465
16	STK16	1.85692644
17	MAP4K1	1.75450099
18	CDK19	1.67963564
19	WNK4	1.61842499
20	ITK	1.59945553
21	EIF2AK3	1.58510192
22	TRIM28	1.54131528
23	FES	1.52312683
24	VRK1	1.46571365
25	IKBKB	1.44412450
26	OXSR1	1.35175488
27	PINK1	1.33013029
28	SCYL2	1.26842474
29	CSNK1G3	1.25866610
30	STK39	1.24067080
31	TESK2	1.18668877
32	BMPR1B	1.18222482
33	CSNK1G2	1.08490877
34	BUB1	1.07527784
35	DAPK1	1.06025545
36	TAF1	1.03490733
37	CSNK1A1L	1.03363124
38	SYK	1.02887046
39	KIT	1.01669028
40	PRKCQ	1.01653927
41	MST4	1.01471291
42	DYRK2	1.01402260
43	MAPKAPK5	1.00738533
44	MAPKAPK3	1.00265157
45	MAP3K12	0.99234701
46	CSNK1G1	0.97552461
47	MKNK1	0.94044806
48	BTK	0.93316799
49	TSSK6	0.90247204
50	ERBB3	0.87211585
51	GRK6	0.86069451
52	TNK2	0.82774087
53	MAP2K6	0.82167399
54	PASK	0.76340036
55	ADRBK1	0.74851827
56	RPS6KA5	0.72016087
57	EIF2AK2	0.70916963
58	MAP2K7	0.69036656
59	LCK	0.67701715
60	BCR	0.67326381
61	CAMKK2	0.66619349
62	LYN	0.63411235
63	INSRR	0.60898388
64	DAPK2	0.60602146
65	GRK5	0.60207837
66	ACVR1B	0.59940256
67	IKBKE	0.57578901
68	PHKG1	0.56875219
69	PHKG2	0.56875219
70	TBK1	0.53817699
71	EPHA4	0.52475607
72	MAPK13	0.50584789
73	CSNK1A1	0.50117597
74	FLT3	0.49823094
75	MAP3K14	0.49444359
76	PLK3	0.48820364
77	WNK3	0.47491415
78	IGF1R	0.45533694
79	NME1	0.45278368
80	CSF1R	0.45131768
81	CHUK	0.44990233
82	JAK3	0.42396818
83	PIK3CA	0.41491080
84	MAP3K4	0.38079925
85	PRKCG	0.36823175
86	ATR	0.36403425
87	PIM2	0.36084905
88	EIF2AK1	0.36078951
89	PRKCA	0.35743607
90	TGFBR1	0.35017532
91	BMPR2	0.34444991
92	PLK2	0.34301643
93	SIK2	0.34073655
94	ZAP70	0.33742142
95	MATK	0.33388429
96	PRKCI	0.32620660
97	ABL1	0.32268977
98	PRKCE	0.30193971
99	TNIK	0.27547681
100	PRKACA	0.26963198

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.64985870
2	Asthma_Homo sapiens_hsa05310	2.82329607
3	Allograft rejection_Homo sapiens_hsa05330	2.71870328
4	Graft-versus-host disease_Homo sapiens_hsa05332	2.65013836
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.62115271
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.57965570
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.57007711
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.51361957
9	Parkinsons disease_Homo sapiens_hsa05012	2.16952210
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.13631301
11	Ribosome_Homo sapiens_hsa03010	2.11108075
12	Antigen processing and presentation_Homo sapiens_hsa04612	1.98839924
13	RNA polymerase_Homo sapiens_hsa03020	1.98286138
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88146009
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.85699002
16	Protein export_Homo sapiens_hsa03060	1.79940915
17	Phototransduction_Homo sapiens_hsa04744	1.70375096
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.68978564
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68040334
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.66293606
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62937205
22	One carbon pool by folate_Homo sapiens_hsa00670	1.62174041
23	Propanoate metabolism_Homo sapiens_hsa00640	1.62024779
24	Homologous recombination_Homo sapiens_hsa03440	1.56162891
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.49637088
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.46916127
27	Caffeine metabolism_Homo sapiens_hsa00232	1.43165750
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38686326
29	RNA degradation_Homo sapiens_hsa03018	1.35923482
30	Peroxisome_Homo sapiens_hsa04146	1.33605626
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.30534609
32	Alzheimers disease_Homo sapiens_hsa05010	1.29387880
33	Huntingtons disease_Homo sapiens_hsa05016	1.29263027
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.28529195
35	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.27058735
36	Basal transcription factors_Homo sapiens_hsa03022	1.26021328
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.18548095
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17889420
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16572222
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16224431
41	Base excision repair_Homo sapiens_hsa03410	1.15916288
42	Regulation of autophagy_Homo sapiens_hsa04140	1.15308749
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.15078122
44	Pyrimidine metabolism_Homo sapiens_hsa00240	1.11099611
45	Butanoate metabolism_Homo sapiens_hsa00650	1.08186839
46	Rheumatoid arthritis_Homo sapiens_hsa05323	1.04412222
47	Sulfur metabolism_Homo sapiens_hsa00920	1.02057404
48	Mismatch repair_Homo sapiens_hsa03430	1.01853939
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.99716997
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98758109
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96558791
52	Purine metabolism_Homo sapiens_hsa00230	0.94597028
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90652825
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.84162625
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82182610
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.81293670
57	Non-homologous end-joining_Homo sapiens_hsa03450	0.81147865
58	Spliceosome_Homo sapiens_hsa03040	0.80219426
59	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.74998663
60	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.72584915
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70926105
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.70194056
63	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.70109794
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69680920
65	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69209480
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.68273396
67	RNA transport_Homo sapiens_hsa03013	0.67863977
68	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.67638086
69	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.66916504
70	DNA replication_Homo sapiens_hsa03030	0.66529369
71	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.65534785
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64645276
73	Nicotine addiction_Homo sapiens_hsa05033	0.64614817
74	Fat digestion and absorption_Homo sapiens_hsa04975	0.64232903
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63590603
76	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.63293560
77	Olfactory transduction_Homo sapiens_hsa04740	0.61438568
78	Metabolic pathways_Homo sapiens_hsa01100	0.58465423
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58229700
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57556924
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57335481
82	Sulfur relay system_Homo sapiens_hsa04122	0.56940368
83	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52823896
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52571624
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52330906
86	Taste transduction_Homo sapiens_hsa04742	0.52308823
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52181836
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49635546
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48143781
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46212470
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.45152361
92	Herpes simplex infection_Homo sapiens_hsa05168	0.44127813
93	Viral myocarditis_Homo sapiens_hsa05416	0.43815463
94	Retinol metabolism_Homo sapiens_hsa00830	0.43513068
95	Leishmaniasis_Homo sapiens_hsa05140	0.43418679
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36891250
97	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36581204
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36115702
99	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.36091687
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.35030745

RPS3P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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