ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.58196108
2	viral transcription (GO:0019083)	6.11364320
3	translational termination (GO:0006415)	5.95270556
4	ATP synthesis coupled proton transport (GO:0015986)	5.50369472
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.50369472
6	ribosomal small subunit biogenesis (GO:0042274)	5.43564064
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.33577521
8	cotranslational protein targeting to membrane (GO:0006613)	5.30540814
9	protein targeting to ER (GO:0045047)	5.25725825
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.16468030
11	translational elongation (GO:0006414)	5.13983649
12	protein neddylation (GO:0045116)	5.11374509
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.06755467
14	maturation of SSU-rRNA (GO:0030490)	5.05118122
15	protein localization to endoplasmic reticulum (GO:0070972)	4.95887132
16	chaperone-mediated protein transport (GO:0072321)	4.77542998
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.62867738
18	viral life cycle (GO:0019058)	4.62143983
19	cellular protein complex disassembly (GO:0043624)	4.49907763
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.38771098
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.33763480
22	translational initiation (GO:0006413)	4.23228637
23	DNA deamination (GO:0045006)	4.20605449
24	protein complex biogenesis (GO:0070271)	4.04319050
25	respiratory electron transport chain (GO:0022904)	4.03036253
26	electron transport chain (GO:0022900)	4.01703477
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.97316206
28	response to pheromone (GO:0019236)	3.91616627
29	ribosomal large subunit biogenesis (GO:0042273)	3.90683029
30	translation (GO:0006412)	3.90172676
31	GTP biosynthetic process (GO:0006183)	3.89255693
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.86631941
33	NADH dehydrogenase complex assembly (GO:0010257)	3.86631941
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.86631941
35	water-soluble vitamin biosynthetic process (GO:0042364)	3.85825619
36	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.77293523
37	mitochondrial respiratory chain complex assembly (GO:0033108)	3.75598109
38	protein complex disassembly (GO:0043241)	3.73764926
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.72126651
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.72126651
41	macromolecular complex disassembly (GO:0032984)	3.58636260
42	pseudouridine synthesis (GO:0001522)	3.53614051
43	respiratory chain complex IV assembly (GO:0008535)	3.50887744
44	protein targeting to membrane (GO:0006612)	3.44011854
45	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.42298012
46	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.41070968
47	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.39820192
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.32526934
49	UTP biosynthetic process (GO:0006228)	3.31367744
50	cellular component biogenesis (GO:0044085)	3.30389381
51	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.27509450
52	regulation of cilium movement (GO:0003352)	3.27224101
53	ATP biosynthetic process (GO:0006754)	3.25854739
54	ribonucleoprotein complex biogenesis (GO:0022613)	3.24565561
55	behavioral response to nicotine (GO:0035095)	3.24556243
56	mRNA catabolic process (GO:0006402)	3.22279430
57	pyrimidine nucleotide catabolic process (GO:0006244)	3.21775133
58	cytochrome complex assembly (GO:0017004)	3.20857790
59	protein-cofactor linkage (GO:0018065)	3.17970774
60	hydrogen ion transmembrane transport (GO:1902600)	3.17152507
61	tRNA processing (GO:0008033)	3.15709335
62	UTP metabolic process (GO:0046051)	3.08237369
63	resolution of meiotic recombination intermediates (GO:0000712)	3.05836475
64	rRNA modification (GO:0000154)	3.00911972
65	epithelial cilium movement (GO:0003351)	2.99459632
66	rRNA processing (GO:0006364)	2.99328888
67	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.97268964
68	mannosylation (GO:0097502)	2.95235371
69	ncRNA 3-end processing (GO:0043628)	2.95156748
70	neuron fate determination (GO:0048664)	2.95029442
71	proton transport (GO:0015992)	2.93724195
72	rRNA metabolic process (GO:0016072)	2.93157980
73	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.89886164
74	termination of RNA polymerase III transcription (GO:0006386)	2.89886164
75	RNA catabolic process (GO:0006401)	2.89656906
76	regulation of mesoderm development (GO:2000380)	2.87357896
77	hydrogen transport (GO:0006818)	2.86530176
78	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.86250558
79	peptidyl-histidine modification (GO:0018202)	2.85734998
80	branched-chain amino acid catabolic process (GO:0009083)	2.83488476
81	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.82073677
82	intracellular protein transmembrane import (GO:0044743)	2.80408254
83	protein targeting to mitochondrion (GO:0006626)	2.72621371
84	CTP metabolic process (GO:0046036)	2.72227621
85	CTP biosynthetic process (GO:0006241)	2.72227621
86	nucleoside triphosphate biosynthetic process (GO:0009142)	2.70921968
87	intraciliary transport (GO:0042073)	2.70724185
88	regulation of mitochondrial translation (GO:0070129)	2.70424315
89	protein polyglutamylation (GO:0018095)	2.70217589
90	platelet dense granule organization (GO:0060155)	2.68185439
91	establishment of protein localization to mitochondrion (GO:0072655)	2.68090873
92	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.67027450
93	tRNA metabolic process (GO:0006399)	2.65070150
94	nonmotile primary cilium assembly (GO:0035058)	2.63168877
95	regulation of cellular amino acid metabolic process (GO:0006521)	2.62170742
96	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.61841752
97	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.61841752
98	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.61841752
99	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.61588701
100	guanosine-containing compound biosynthetic process (GO:1901070)	2.59351699

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.55391360
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.11592495
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.84742973
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.70763631
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.63560670
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.50355631
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.27227225
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.06229073
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.05105693
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.70503910
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.69162265
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.57885603
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.53022175
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.50431784
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.48089150
16	VDR_22108803_ChIP-Seq_LS180_Human	2.47317998
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.38785820
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.21207695
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.17567178
20	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.13319976
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.08755919
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.08574128
23	FOXP3_21729870_ChIP-Seq_TREG_Human	2.04922761
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.91012474
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.88778592
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.79371210
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.72446778
28	EWS_26573619_Chip-Seq_HEK293_Human	1.70249372
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.59206760
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.52720696
31	FUS_26573619_Chip-Seq_HEK293_Human	1.52282431
32	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.51901321
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45545773
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43706715
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.42957796
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41956090
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.41863939
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.41779651
39	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.41189470
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40185914
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.38902170
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.38686848
43	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.36926286
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34652031
45	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.34351350
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33517812
47	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.29563737
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.29382853
49	XRN2_22483619_ChIP-Seq_HELA_Human	1.27615920
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24130413
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.21646686
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20571204
53	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18868680
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16513627
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16513627
56	P300_19829295_ChIP-Seq_ESCs_Human	1.15560991
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14454472
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14405620
59	DCP1A_22483619_ChIP-Seq_HELA_Human	1.14294084
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12301537
61	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.12208884
62	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.08312193
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.07137981
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05825691
65	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05788670
66	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.05123010
67	NCOR_22424771_ChIP-Seq_293T_Human	1.04252981
68	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03908555
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03897626
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03897626
71	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.00864279
72	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.00388058
73	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.98043842
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97846156
75	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.95313982
76	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.94613920
77	AR_20517297_ChIP-Seq_VCAP_Human	0.94201513
78	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93926270
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.93494894
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93494894
81	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.93187421
82	MYC_19829295_ChIP-Seq_ESCs_Human	0.92882709
83	CIITA_25753668_ChIP-Seq_RAJI_Human	0.92863440
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92065099
85	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.91205923
86	ER_23166858_ChIP-Seq_MCF-7_Human	0.90146628
87	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.90060784
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89619243
89	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.89028999
90	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.88745830
91	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.88600483
92	BCAT_22108803_ChIP-Seq_LS180_Human	0.88302788
93	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.87957145
94	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.87605602
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86441816
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.86398920
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.86219524
98	ERA_21632823_ChIP-Seq_H3396_Human	0.84995315
99	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.84987274
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.83517156

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.38148436
2	MP0009379_abnormal_foot_pigmentation	3.97506695
3	MP0003646_muscle_fatigue	3.36687085
4	MP0000372_irregular_coat_pigmentation	2.77157976
5	MP0001293_anophthalmia	2.68086397
6	MP0002102_abnormal_ear_morphology	2.32469754
7	MP0004142_abnormal_muscle_tone	2.31198421
8	MP0008789_abnormal_olfactory_epithelium	2.27961680
9	MP0008058_abnormal_DNA_repair	2.26497473
10	MP0003787_abnormal_imprinting	2.15419459
11	MP0004147_increased_porphyrin_level	2.02998500
12	MP0002837_dystrophic_cardiac_calcinosis	2.00469341
13	MP0002938_white_spotting	1.94465582
14	MP0002163_abnormal_gland_morphology	1.92114696
15	MP0005499_abnormal_olfactory_system	1.89127662
16	MP0005394_taste/olfaction_phenotype	1.89127662
17	MP0008877_abnormal_DNA_methylation	1.88891711
18	MP0001968_abnormal_touch/_nociception	1.79230315
19	MP0004133_heterotaxia	1.78733769
20	MP0002736_abnormal_nociception_after	1.78392399
21	MP0002234_abnormal_pharynx_morphology	1.77117918
22	MP0005379_endocrine/exocrine_gland_phen	1.76179590
23	MP0000049_abnormal_middle_ear	1.75355496
24	MP0010030_abnormal_orbit_morphology	1.73131894
25	MP0003122_maternal_imprinting	1.72127057
26	MP0003186_abnormal_redox_activity	1.66461526
27	MP0005075_abnormal_melanosome_morpholog	1.63158141
28	MP0005551_abnormal_eye_electrophysiolog	1.60796402
29	MP0001485_abnormal_pinna_reflex	1.58980468
30	MP0005084_abnormal_gallbladder_morpholo	1.54044385
31	MP0003890_abnormal_embryonic-extraembry	1.53075633
32	MP0008872_abnormal_physiological_respon	1.52524767
33	MP0001984_abnormal_olfaction	1.45080648
34	MP0000631_abnormal_neuroendocrine_gland	1.41890670
35	MP0004885_abnormal_endolymph	1.31229272
36	MP0002272_abnormal_nervous_system	1.30597156
37	MP0005646_abnormal_pituitary_gland	1.28891208
38	MP0006276_abnormal_autonomic_nervous	1.28304761
39	MP0008775_abnormal_heart_ventricle	1.26937249
40	MP0001986_abnormal_taste_sensitivity	1.26428622
41	MP0003121_genomic_imprinting	1.24255939
42	MP0002876_abnormal_thyroid_physiology	1.23453097
43	MP0002095_abnormal_skin_pigmentation	1.23421093
44	MP0003786_premature_aging	1.18702159
45	MP0006036_abnormal_mitochondrial_physio	1.18382071
46	MP0005377_hearing/vestibular/ear_phenot	1.15772098
47	MP0003878_abnormal_ear_physiology	1.15772098
48	MP0003938_abnormal_ear_development	1.15745599
49	MP0002733_abnormal_thermal_nociception	1.15535834
50	MP0002138_abnormal_hepatobiliary_system	1.14901927
51	MP0006072_abnormal_retinal_apoptosis	1.13994543
52	MP0005645_abnormal_hypothalamus_physiol	1.13041903
53	MP0003567_abnormal_fetal_cardiomyocyte	1.11558794
54	MP0001764_abnormal_homeostasis	1.11462078
55	MP0001970_abnormal_pain_threshold	1.10967431
56	MP0005195_abnormal_posterior_eye	1.10443662
57	MP0008875_abnormal_xenobiotic_pharmacok	1.09810186
58	MP0001529_abnormal_vocalization	1.09201351
59	MP0003136_yellow_coat_color	1.05991331
60	MP0002557_abnormal_social/conspecific_i	1.05828214
61	MP0002233_abnormal_nose_morphology	1.05626499
62	MP0001919_abnormal_reproductive_system	1.04283211
63	MP0001905_abnormal_dopamine_level	1.03997941
64	MP0006035_abnormal_mitochondrial_morpho	1.01689525
65	MP0002638_abnormal_pupillary_reflex	0.98268083
66	MP0004145_abnormal_muscle_electrophysio	0.98027908
67	MP0001286_abnormal_eye_development	0.97701823
68	MP0005389_reproductive_system_phenotype	0.97249151
69	MP0005253_abnormal_eye_physiology	0.96818557
70	MP0005171_absent_coat_pigmentation	0.93846579
71	MP0003718_maternal_effect	0.93269390
72	MP0002752_abnormal_somatic_nervous	0.90704214
73	MP0009745_abnormal_behavioral_response	0.90271867
74	MP0008007_abnormal_cellular_replicative	0.88981837
75	MP0010094_abnormal_chromosome_stability	0.88658340
76	MP0001324_abnormal_eye_pigmentation	0.87608814
77	MP0002210_abnormal_sex_determination	0.86596784
78	MP0005391_vision/eye_phenotype	0.86328941
79	MP0000026_abnormal_inner_ear	0.86009122
80	MP0002184_abnormal_innervation	0.85941868
81	MP0005174_abnormal_tail_pigmentation	0.85671510
82	MP0003936_abnormal_reproductive_system	0.85004531
83	MP0003693_abnormal_embryo_hatching	0.81769715
84	MP0003880_abnormal_central_pattern	0.81689951
85	MP0002734_abnormal_mechanical_nocicepti	0.81173909
86	MP0002160_abnormal_reproductive_system	0.80928875
87	MP0000653_abnormal_sex_gland	0.79167436
88	MP0004043_abnormal_pH_regulation	0.79133451
89	MP0001440_abnormal_grooming_behavior	0.77686459
90	MP0001486_abnormal_startle_reflex	0.77217595
91	MP0003119_abnormal_digestive_system	0.77045308
92	MP0003937_abnormal_limbs/digits/tail_de	0.76297736
93	MP0001881_abnormal_mammary_gland	0.74767569
94	MP0003283_abnormal_digestive_organ	0.73828399
95	MP0001145_abnormal_male_reproductive	0.72344375
96	MP0009046_muscle_twitch	0.70939666
97	MP0002572_abnormal_emotion/affect_behav	0.70900803
98	MP0002277_abnormal_respiratory_mucosa	0.70331402
99	MP0000613_abnormal_salivary_gland	0.69159824
100	MP0002822_catalepsy	0.68608007

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.68350516
2	Acute encephalopathy (HP:0006846)	4.60852488
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.15336001
4	Reticulocytopenia (HP:0001896)	4.07347700
5	Mitochondrial inheritance (HP:0001427)	3.86281921
6	Hyperglycinemia (HP:0002154)	3.82208856
7	Progressive macrocephaly (HP:0004481)	3.81638421
8	Increased CSF lactate (HP:0002490)	3.52886269
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.44899260
10	Oligodactyly (hands) (HP:0001180)	3.38291758
11	Hepatocellular necrosis (HP:0001404)	3.31069889
12	Increased hepatocellular lipid droplets (HP:0006565)	3.23993871
13	Colon cancer (HP:0003003)	3.22664831
14	Cerebral edema (HP:0002181)	3.11518046
15	Pancreatic cysts (HP:0001737)	3.07820893
16	Type II lissencephaly (HP:0007260)	3.03460015
17	Lipid accumulation in hepatocytes (HP:0006561)	2.99761568
18	Hepatic necrosis (HP:0002605)	2.99277323
19	Hyperglycinuria (HP:0003108)	2.94765472
20	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.91633764
21	3-Methylglutaconic aciduria (HP:0003535)	2.77839158
22	Pancreatic fibrosis (HP:0100732)	2.77669821
23	Abnormality of midbrain morphology (HP:0002418)	2.77595980
24	Molar tooth sign on MRI (HP:0002419)	2.77595980
25	Abnormal number of erythroid precursors (HP:0012131)	2.76301771
26	Macrocytic anemia (HP:0001972)	2.70269045
27	Nephronophthisis (HP:0000090)	2.68660158
28	Optic disc pallor (HP:0000543)	2.67073572
29	Renal Fanconi syndrome (HP:0001994)	2.66985242
30	Oligodactyly (HP:0012165)	2.66169429
31	Anophthalmia (HP:0000528)	2.64475981
32	Stenosis of the external auditory canal (HP:0000402)	2.63892401
33	Increased serum lactate (HP:0002151)	2.62541443
34	Lactic acidosis (HP:0003128)	2.60013129
35	Medial flaring of the eyebrow (HP:0010747)	2.56510831
36	Septo-optic dysplasia (HP:0100842)	2.51002367
37	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.50601139
38	True hermaphroditism (HP:0010459)	2.48770920
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.44532873
40	Abnormality of glycine metabolism (HP:0010895)	2.43097783
41	Abnormality of serine family amino acid metabolism (HP:0010894)	2.43097783
42	Lethargy (HP:0001254)	2.42928821
43	Abolished electroretinogram (ERG) (HP:0000550)	2.39348282
44	Abnormality of the labia minora (HP:0012880)	2.35187646
45	Absent thumb (HP:0009777)	2.34753070
46	Horseshoe kidney (HP:0000085)	2.32178812
47	Congenital stationary night blindness (HP:0007642)	2.31521080
48	Asplenia (HP:0001746)	2.31473439
49	Increased intramyocellular lipid droplets (HP:0012240)	2.31471779
50	Supernumerary spleens (HP:0009799)	2.26805441
51	Absent/shortened dynein arms (HP:0200106)	2.26220700
52	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26220700
53	Abnormal respiratory epithelium morphology (HP:0012253)	2.23626120
54	Abnormal respiratory motile cilium morphology (HP:0005938)	2.23626120
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.23499402
56	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.23499402
57	Abnormality of the renal medulla (HP:0100957)	2.20045386
58	Abnormality of the renal cortex (HP:0011035)	2.12150193
59	Anencephaly (HP:0002323)	2.10796593
60	Exertional dyspnea (HP:0002875)	2.09802301
61	Sclerocornea (HP:0000647)	2.09086363
62	Respiratory failure (HP:0002878)	2.08351322
63	Renal cortical cysts (HP:0000803)	2.07642104
64	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.07531887
65	Chronic hepatic failure (HP:0100626)	2.07128261
66	Pallor (HP:0000980)	2.05910916
67	Methylmalonic aciduria (HP:0012120)	2.05816612
68	Limb hypertonia (HP:0002509)	2.05229318
69	Cerebellar dysplasia (HP:0007033)	2.04467665
70	Pancytopenia (HP:0001876)	2.04061679
71	Abnormal rod and cone electroretinograms (HP:0008323)	2.03806822
72	Esophageal atresia (HP:0002032)	2.03013730
73	Lissencephaly (HP:0001339)	2.01240473
74	Methylmalonic acidemia (HP:0002912)	1.99580716
75	Triphalangeal thumb (HP:0001199)	1.97038068
76	Abnormality of abdominal situs (HP:0011620)	1.96804882
77	Abdominal situs inversus (HP:0003363)	1.96804882
78	Exercise intolerance (HP:0003546)	1.96131391
79	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.94696299
80	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92593639
81	Hypoplasia of the radius (HP:0002984)	1.89454910
82	Abnormal ciliary motility (HP:0012262)	1.84892441
83	Progressive inability to walk (HP:0002505)	1.84775524
84	Gait imbalance (HP:0002141)	1.84667503
85	Glycosuria (HP:0003076)	1.84348532
86	Abnormality of urine glucose concentration (HP:0011016)	1.84348532
87	Congenital malformation of the right heart (HP:0011723)	1.83810227
88	Double outlet right ventricle (HP:0001719)	1.83810227
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.82934694
90	Postaxial foot polydactyly (HP:0001830)	1.82934271
91	Abnormality of serum amino acid levels (HP:0003112)	1.82399853
92	Increased muscle lipid content (HP:0009058)	1.82209716
93	Cleft eyelid (HP:0000625)	1.81673650
94	Abnormality of DNA repair (HP:0003254)	1.81017448
95	Intestinal atresia (HP:0011100)	1.80141828
96	Congenital primary aphakia (HP:0007707)	1.79776844
97	Forearm undergrowth (HP:0009821)	1.79560407
98	Rib fusion (HP:0000902)	1.79306702
99	Cystic liver disease (HP:0006706)	1.79257118
100	Hypomagnesemia (HP:0002917)	1.77718398

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.51349590
2	BCKDK	3.33182809
3	STK16	3.32823370
4	NUAK1	2.69461886
5	ZAK	2.63656746
6	WNK4	2.58974552
7	TNIK	2.18633833
8	TRIM28	2.18358848
9	ADRBK2	2.13604468
10	GRK1	2.13025445
11	PDK2	2.01308335
12	NME1	1.87606316
13	NME2	1.87225571
14	PBK	1.81091320
15	FRK	1.75351052
16	NEK1	1.75281571
17	TXK	1.73455476
18	BMPR1B	1.71627734
19	DYRK2	1.70409612
20	VRK1	1.60673344
21	WNK3	1.60469569
22	TAF1	1.50215405
23	LRRK2	1.33574331
24	MAP3K4	1.33509506
25	ERBB4	1.24088239
26	STK39	1.22857693
27	MAP3K12	1.21996699
28	CDC7	1.19569674
29	PLK3	1.18914646
30	TEC	1.18264772
31	INSRR	1.17526407
32	BCR	1.14723635
33	MAP4K2	1.14356676
34	BUB1	1.06623783
35	PLK4	1.06171368
36	TIE1	1.05576795
37	MKNK1	1.04738897
38	ACVR1B	0.97608953
39	PINK1	0.97318953
40	PRKCG	0.97030899
41	MAPKAPK5	0.96687391
42	OXSR1	0.93356322
43	PHKG1	0.93309196
44	PHKG2	0.93309196
45	CDK19	0.92927974
46	CSNK1G2	0.92410605
47	TLK1	0.90837724
48	WEE1	0.90408391
49	PIK3CA	0.90024106
50	CAMKK2	0.89496708
51	DAPK3	0.87158360
52	CSNK1G3	0.86891695
53	TAOK3	0.86519925
54	CAMK1	0.84892395
55	CSNK1G1	0.84130324
56	EIF2AK1	0.83949990
57	PLK1	0.82437908
58	BRSK2	0.82398796
59	ATR	0.81624752
60	SRPK1	0.78405208
61	TGFBR1	0.77707125
62	PLK2	0.75275938
63	SIK3	0.73959188
64	ADRBK1	0.71788454
65	MAPK13	0.70828363
66	AURKB	0.70442649
67	EIF2AK3	0.70382067
68	CSNK2A2	0.65167561
69	MINK1	0.64300240
70	BRSK1	0.59687521
71	RPS6KA5	0.58664314
72	KIT	0.58032023
73	CSNK2A1	0.58007844
74	PRKCQ	0.57728742
75	ITK	0.57517569
76	TSSK6	0.56504013
77	CSNK1A1L	0.56492122
78	BTK	0.55063645
79	EPHA4	0.54683997
80	PRKACA	0.52560377
81	CHEK2	0.52253502
82	WNK1	0.51075715
83	DYRK1B	0.49394252
84	MKNK2	0.45887260
85	ATM	0.45833604
86	PAK3	0.45725314
87	CAMK2A	0.45063550
88	PASK	0.42993583
89	PRKCE	0.42787688
90	CSNK1E	0.42444226
91	EIF2AK2	0.42153784
92	STK4	0.41919609
93	CSNK1A1	0.41000839
94	OBSCN	0.40710193
95	PRKCA	0.40438424
96	DYRK1A	0.40438093
97	PRKDC	0.39275087
98	ILK	0.38134577
99	MAP2K7	0.37822874
100	EPHB2	0.36527748

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.10722878
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.88902630
3	Parkinsons disease_Homo sapiens_hsa05012	3.41082308
4	Proteasome_Homo sapiens_hsa03050	3.37874990
5	Protein export_Homo sapiens_hsa03060	2.46106500
6	RNA polymerase_Homo sapiens_hsa03020	2.35819806
7	Huntingtons disease_Homo sapiens_hsa05016	2.33978295
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22864989
9	Alzheimers disease_Homo sapiens_hsa05010	2.13631017
10	Mismatch repair_Homo sapiens_hsa03430	2.08723240
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05279983
12	Homologous recombination_Homo sapiens_hsa03440	1.99023018
13	Basal transcription factors_Homo sapiens_hsa03022	1.97862816
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96659730
15	Propanoate metabolism_Homo sapiens_hsa00640	1.91333313
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.87822893
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.77194153
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.73475431
19	RNA degradation_Homo sapiens_hsa03018	1.69145634
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.68224444
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.64436868
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.62386378
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.56016177
24	One carbon pool by folate_Homo sapiens_hsa00670	1.52319809
25	Base excision repair_Homo sapiens_hsa03410	1.46200473
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.44484952
27	Phototransduction_Homo sapiens_hsa04744	1.41033414
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39000550
29	Asthma_Homo sapiens_hsa05310	1.38080445
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34334303
31	Peroxisome_Homo sapiens_hsa04146	1.33184626
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.31688269
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30428913
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.23328658
35	Non-homologous end-joining_Homo sapiens_hsa03450	1.21674049
36	Butanoate metabolism_Homo sapiens_hsa00650	1.17647263
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.14008376
38	DNA replication_Homo sapiens_hsa03030	1.12243199
39	Purine metabolism_Homo sapiens_hsa00230	1.10607290
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.09871300
41	RNA transport_Homo sapiens_hsa03013	1.01460736
42	Nitrogen metabolism_Homo sapiens_hsa00910	1.00831512
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00000943
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.97874420
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97366202
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.93570475
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.92895778
48	Nicotine addiction_Homo sapiens_hsa05033	0.91745963
49	Fatty acid elongation_Homo sapiens_hsa00062	0.89101666
50	Allograft rejection_Homo sapiens_hsa05330	0.86796711
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.86302520
52	Metabolic pathways_Homo sapiens_hsa01100	0.85207146
53	Spliceosome_Homo sapiens_hsa03040	0.81769501
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81582775
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79687600
56	Graft-versus-host disease_Homo sapiens_hsa05332	0.76999057
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.76497865
58	Glutathione metabolism_Homo sapiens_hsa00480	0.75583325
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75176498
60	Sulfur relay system_Homo sapiens_hsa04122	0.73882410
61	Retinol metabolism_Homo sapiens_hsa00830	0.70357852
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67775029
63	Caffeine metabolism_Homo sapiens_hsa00232	0.67407500
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.64463754
65	Folate biosynthesis_Homo sapiens_hsa00790	0.63392142
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61960100
67	Olfactory transduction_Homo sapiens_hsa04740	0.61788683
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60749128
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.56150953
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54546386
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53982101
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53882615
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53394760
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53276763
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52331410
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52282038
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52073698
78	Fatty acid degradation_Homo sapiens_hsa00071	0.51242080
79	Taste transduction_Homo sapiens_hsa04742	0.49163795
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.48616215
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.48247073
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.46466183
83	Sulfur metabolism_Homo sapiens_hsa00920	0.44924648
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43900329
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43267674
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42117784
87	Carbon metabolism_Homo sapiens_hsa01200	0.40416706
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37563568
89	p53 signaling pathway_Homo sapiens_hsa04115	0.37502732
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36845605
91	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.36795855
92	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36151478
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.33367259
94	Primary immunodeficiency_Homo sapiens_hsa05340	0.29922959
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.27871797
96	Morphine addiction_Homo sapiens_hsa05032	0.25986784
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.24307486
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.24005194
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.19999954
100	Antigen processing and presentation_Homo sapiens_hsa04612	0.19552792

RPS3P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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