RPS4X

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.23953766
2* viral transcription (GO:0019083)7.68870523
3* translational termination (GO:0006415)7.45359449
4* translational elongation (GO:0006414)6.49944306
5ribosomal small subunit biogenesis (GO:0042274)6.41819506
6maturation of SSU-rRNA (GO:0030490)6.39905290
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.24176595
8* protein targeting to ER (GO:0045047)6.09075732
9* cotranslational protein targeting to membrane (GO:0006613)6.08957526
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.04350685
11* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.82762867
12* viral life cycle (GO:0019058)5.73516557
13* cellular protein complex disassembly (GO:0043624)5.71594500
14* translational initiation (GO:0006413)5.71215480
15* protein localization to endoplasmic reticulum (GO:0070972)5.67846492
16ribosomal large subunit biogenesis (GO:0042273)5.18427073
17* protein complex disassembly (GO:0043241)5.11458229
18* macromolecular complex disassembly (GO:0032984)4.75820890
19formation of translation preinitiation complex (GO:0001731)4.54755599
20* nuclear-transcribed mRNA catabolic process (GO:0000956)4.47464010
21DNA unwinding involved in DNA replication (GO:0006268)4.36025449
22* mRNA catabolic process (GO:0006402)4.25273949
23ribonucleoprotein complex biogenesis (GO:0022613)4.09860847
24* RNA catabolic process (GO:0006401)4.04140231
25* protein targeting to membrane (GO:0006612)4.02694362
26DNA strand elongation involved in DNA replication (GO:0006271)3.98761939
27DNA strand elongation (GO:0022616)3.80297194
28* translation (GO:0006412)3.79238495
29telomere maintenance via semi-conservative replication (GO:0032201)3.76156622
30DNA replication initiation (GO:0006270)3.52835146
31* protein targeting (GO:0006605)3.52672066
32rRNA processing (GO:0006364)3.32755024
33telomere maintenance via recombination (GO:0000722)3.31197708
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30027012
35protein localization to kinetochore (GO:0034501)3.28145833
36negative regulation of RNA splicing (GO:0033119)3.27843523
37mitotic recombination (GO:0006312)3.23853556
38rRNA metabolic process (GO:0016072)3.22019859
39IMP biosynthetic process (GO:0006188)3.18639753
40folic acid-containing compound biosynthetic process (GO:0009396)3.13923005
41nucleobase biosynthetic process (GO:0046112)3.12184270
42* protein localization to membrane (GO:0072657)3.07733065
43mitotic nuclear envelope disassembly (GO:0007077)2.99930629
44energy coupled proton transport, down electrochemical gradient (GO:0015985)2.99922801
45ATP synthesis coupled proton transport (GO:0015986)2.99922801
46telomere maintenance via telomere lengthening (GO:0010833)2.99681033
47DNA deamination (GO:0045006)2.99026553
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98487799
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98487799
50IMP metabolic process (GO:0046040)2.96086596
51ribonucleoprotein complex subunit organization (GO:0071826)2.91821077
52nucleotide-excision repair, DNA gap filling (GO:0006297)2.91721479
53ribosome assembly (GO:0042255)2.86899642
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86352513
55ncRNA 3-end processing (GO:0043628)2.85445550
56ribosome biogenesis (GO:0042254)2.85232955
57heterochromatin organization (GO:0070828)2.83946104
58CENP-A containing nucleosome assembly (GO:0034080)2.83535924
59protein localization to chromosome, centromeric region (GO:0071459)2.82820944
60cellular component biogenesis (GO:0044085)2.81127748
61chromatin remodeling at centromere (GO:0031055)2.77799299
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77791964
63nuclear envelope disassembly (GO:0051081)2.76879823
64membrane disassembly (GO:0030397)2.76879823
65DNA duplex unwinding (GO:0032508)2.76001897
66DNA replication-independent nucleosome assembly (GO:0006336)2.75377012
67DNA replication-independent nucleosome organization (GO:0034724)2.75377012
68purine nucleobase biosynthetic process (GO:0009113)2.74748708
69DNA geometric change (GO:0032392)2.73543003
70myeloid cell homeostasis (GO:0002262)2.73085899
71nuclear pore organization (GO:0006999)2.72490710
72* cellular component disassembly (GO:0022411)2.72266256
73DNA replication-dependent nucleosome assembly (GO:0006335)2.71661023
74DNA replication-dependent nucleosome organization (GO:0034723)2.71661023
75translesion synthesis (GO:0019985)2.68401451
76* establishment of protein localization to membrane (GO:0090150)2.63879309
77* protein localization to organelle (GO:0033365)2.63757973
78mitotic sister chromatid segregation (GO:0000070)2.61786042
79pseudouridine synthesis (GO:0001522)2.61751699
80sister chromatid segregation (GO:0000819)2.60600840
81DNA replication checkpoint (GO:0000076)2.60431304
82establishment of integrated proviral latency (GO:0075713)2.59563179
83definitive hemopoiesis (GO:0060216)2.58314388
84nuclear pore complex assembly (GO:0051292)2.57084887
85mRNA splicing, via spliceosome (GO:0000398)2.56223988
86RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.56223988
87mitotic chromosome condensation (GO:0007076)2.55894038
88RNA splicing, via transesterification reactions (GO:0000375)2.54892706
89antigen processing and presentation of endogenous antigen (GO:0019883)2.54669476
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.52533021
91negative regulation of DNA repair (GO:0045738)2.52528822
92* establishment of protein localization to organelle (GO:0072594)2.52510760
93regulation of histone H3-K9 methylation (GO:0051570)2.52232071
94mitotic metaphase plate congression (GO:0007080)2.52067871
95regulation of translational initiation (GO:0006446)2.51604767
96guanosine-containing compound biosynthetic process (GO:1901070)2.49911821
97kinetochore organization (GO:0051383)2.49054744
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.48635927
99regulation of mitochondrial translation (GO:0070129)2.47232622
100dosage compensation (GO:0007549)2.46082446
101DNA topological change (GO:0006265)2.45510831
102negative regulation of histone methylation (GO:0031061)2.45411749
103pore complex assembly (GO:0046931)2.45129470
104regulation of spindle organization (GO:0090224)2.44080723
105rRNA transcription (GO:0009303)2.44035110
106telomere maintenance (GO:0000723)2.42986903
107spliceosomal snRNP assembly (GO:0000387)2.42320197
108alternative mRNA splicing, via spliceosome (GO:0000380)2.42064868
109mitotic sister chromatid cohesion (GO:0007064)2.41932361
110negative regulation of mRNA processing (GO:0050686)2.41871376
111telomere organization (GO:0032200)2.41657774
112chromatin assembly or disassembly (GO:0006333)2.41110819
113termination of RNA polymerase II transcription (GO:0006369)2.40847435
114* gene expression (GO:0010467)2.40720693
1153-UTR-mediated mRNA stabilization (GO:0070935)2.38892704
116regulation of translational fidelity (GO:0006450)2.38622568
117ribonucleoprotein complex assembly (GO:0022618)2.38440324
118nucleobase-containing small molecule interconversion (GO:0015949)2.36750582
119ncRNA processing (GO:0034470)2.36350718
120deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.36294106
121metaphase plate congression (GO:0051310)2.36036994
122pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.35319038
123mRNA stabilization (GO:0048255)2.34202668
124RNA stabilization (GO:0043489)2.34202668
125histone H2B ubiquitination (GO:0033523)2.32536666
126viral mRNA export from host cell nucleus (GO:0046784)2.31971244
127establishment of protein localization to mitochondrial membrane (GO:0090151)2.30024397
128pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.29175593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.73788246
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.33751253
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80880701
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.31914122
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11323086
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10572418
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65557729
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.59115789
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55085974
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.54451900
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51845913
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49297717
13MYC_22102868_ChIP-Seq_BL_Human2.48692075
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.39913529
15* XRN2_22483619_ChIP-Seq_HELA_Human2.38108489
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.34784542
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18400030
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13566536
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10835144
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09219878
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06654504
22VDR_23849224_ChIP-Seq_CD4+_Human2.06454427
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04260381
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00914408
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94799011
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93681493
27FOXP3_21729870_ChIP-Seq_TREG_Human1.86947153
28* TTF2_22483619_ChIP-Seq_HELA_Human1.86160314
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.80286747
30VDR_21846776_ChIP-Seq_THP-1_Human1.75106046
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73165467
32CIITA_25753668_ChIP-Seq_RAJI_Human1.72375099
33AR_21909140_ChIP-Seq_LNCAP_Human1.71913484
34DCP1A_22483619_ChIP-Seq_HELA_Human1.71362748
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.71353528
36ELK1_19687146_ChIP-ChIP_HELA_Human1.67743574
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64935312
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59195773
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58611843
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55166737
41GABP_19822575_ChIP-Seq_HepG2_Human1.54165956
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52522153
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52331055
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51199553
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50054075
46SCL_19346495_ChIP-Seq_HPC-7_Human1.47973326
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43248423
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42357162
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41361602
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40970455
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38701032
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.34057754
53SPI1_23547873_ChIP-Seq_NB4_Human1.33144616
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32750473
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30723169
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30446734
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29952710
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29680973
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29642775
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27871166
61ZNF263_19887448_ChIP-Seq_K562_Human1.27465843
62KDM5A_27292631_Chip-Seq_BREAST_Human1.26629583
63* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20744772
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20375779
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20170858
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18912165
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17894326
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17832104
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17251268
70MAF_26560356_Chip-Seq_TH1_Human1.17046435
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16625209
72* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15303339
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.14920564
74MYB_26560356_Chip-Seq_TH2_Human1.14057553
75UTX_26944678_Chip-Seq_JUKART_Human1.12822841
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12588916
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.11724480
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10234445
79TFEB_21752829_ChIP-Seq_HELA_Human1.10092776
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09148634
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08990135
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08673103
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08624646
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07993453
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07300427
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05593301
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05582022
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04624644
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04624644
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04624644
91MYB_26560356_Chip-Seq_TH1_Human1.04021339
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03421591
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03414005
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01845861
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00726942
96MYC_18940864_ChIP-ChIP_HL60_Human1.00533629
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00128073
98TCF7_22412390_ChIP-Seq_EML_Mouse0.99703974
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99545712
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99215333
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97710529
102VDR_24763502_ChIP-Seq_THP-1_Human0.97554632
103* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96701801
104PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96679974
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.96392576
106RUNX1_22412390_ChIP-Seq_EML_Mouse0.96004734
107CHD1_26751641_Chip-Seq_LNCaP_Human0.95406396
108FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93875926
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93415067
110SRF_21415370_ChIP-Seq_HL-1_Mouse0.92525902
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91481208
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90991555
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90832820
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89578817
115MAF_26560356_Chip-Seq_TH2_Human0.89324630
116YY1_21170310_ChIP-Seq_MESCs_Mouse0.89032746
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83485629
118* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82742034
119* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81333452
120TET1_21451524_ChIP-Seq_MESCs_Mouse0.80999116
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80865556
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78847986
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77666820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.80324036
2MP0004957_abnormal_blastocyst_morpholog3.29451856
3MP0002396_abnormal_hematopoietic_system3.18846085
4MP0010094_abnormal_chromosome_stability3.15744275
5MP0003077_abnormal_cell_cycle2.91796534
6MP0003111_abnormal_nucleus_morphology2.79994808
7MP0010352_gastrointestinal_tract_polyps2.46295770
8MP0008057_abnormal_DNA_replication2.38517711
9MP0004808_abnormal_hematopoietic_stem2.34243388
10MP0008007_abnormal_cellular_replicative2.29345144
11MP0009379_abnormal_foot_pigmentation2.26189271
12MP0003763_abnormal_thymus_physiology2.22184328
13MP0008058_abnormal_DNA_repair2.08373249
14MP0000490_abnormal_crypts_of2.06798032
15MP0006054_spinal_hemorrhage1.93463896
16MP0005397_hematopoietic_system_phenotyp1.79276613
17MP0001545_abnormal_hematopoietic_system1.79276613
18MP0000350_abnormal_cell_proliferation1.72354910
19MP0000685_abnormal_immune_system1.70949167
20MP0002166_altered_tumor_susceptibility1.69080807
21MP0002398_abnormal_bone_marrow1.68746988
22MP0000566_synostosis1.68200191
23MP0001730_embryonic_growth_arrest1.64585588
24MP0001835_abnormal_antigen_presentation1.64066771
25MP0009333_abnormal_splenocyte_physiolog1.63572361
26MP0008995_early_reproductive_senescence1.60853566
27MP0008932_abnormal_embryonic_tissue1.53497149
28MP0001346_abnormal_lacrimal_gland1.52892755
29MP0003123_paternal_imprinting1.52874697
30MP0000703_abnormal_thymus_morphology1.52380341
31MP0004185_abnormal_adipocyte_glucose1.51476966
32MP0010307_abnormal_tumor_latency1.50223804
33MP0003567_abnormal_fetal_cardiomyocyte1.49925442
34MP0002722_abnormal_immune_system1.49220307
35MP0000465_gastrointestinal_hemorrhage1.48198429
36MP0009278_abnormal_bone_marrow1.46553567
37MP0002019_abnormal_tumor_incidence1.43218409
38MP0001800_abnormal_humoral_immune1.43113520
39MP0000689_abnormal_spleen_morphology1.41585704
40MP0002006_tumorigenesis1.35490369
41MP0006292_abnormal_olfactory_placode1.35185833
42MP0002163_abnormal_gland_morphology1.32917109
43MP0005671_abnormal_response_to1.30470322
44MP0002429_abnormal_blood_cell1.30110478
45MP0001873_stomach_inflammation1.29574230
46MP0003786_premature_aging1.27991368
47MP0001188_hyperpigmentation1.27990923
48MP0000716_abnormal_immune_system1.27942302
49MP0001697_abnormal_embryo_size1.26463952
50MP0002420_abnormal_adaptive_immunity1.25848824
51MP0002080_prenatal_lethality1.24134765
52MP0001819_abnormal_immune_cell1.23031459
53MP0000313_abnormal_cell_death1.22696506
54MP0002452_abnormal_antigen_presenting1.22525669
55MP0010155_abnormal_intestine_physiology1.21854323
56MP0004197_abnormal_fetal_growth/weight/1.18283129
57MP0001672_abnormal_embryogenesis/_devel1.17554086
58MP0005380_embryogenesis_phenotype1.17554086
59MP0002086_abnormal_extraembryonic_tissu1.17443776
60MP0002249_abnormal_larynx_morphology1.17069794
61MP0005174_abnormal_tail_pigmentation1.16223405
62MP0010234_abnormal_vibrissa_follicle1.13349088
63MP0002160_abnormal_reproductive_system1.12067059
64MP0003984_embryonic_growth_retardation1.11984671
65MP0001853_heart_inflammation1.11843099
66MP0002084_abnormal_developmental_patter1.11591816
67MP0002088_abnormal_embryonic_growth/wei1.10945099
68MP0002723_abnormal_immune_serum1.10328919
69MP0005023_abnormal_wound_healing1.09153503
70MP0000537_abnormal_urethra_morphology1.07882713
71MP0002405_respiratory_system_inflammati1.07429406
72MP0000858_altered_metastatic_potential1.07145093
73MP0002095_abnormal_skin_pigmentation1.05831274
74MP0002796_impaired_skin_barrier1.04989618
75MP0002085_abnormal_embryonic_tissue1.04889688
76MP0000678_abnormal_parathyroid_gland1.04721430
77MP0003806_abnormal_nucleotide_metabolis1.04431337
78MP0005076_abnormal_cell_differentiation1.04311342
79MP0003566_abnormal_cell_adhesion1.02702937
80MP0003300_gastrointestinal_ulcer1.01886985
81MP0003866_abnormal_defecation1.00557217
82MP0005025_abnormal_response_to0.99614313
83MP0002697_abnormal_eye_size0.99276719
84MP0003705_abnormal_hypodermis_morpholog0.98562532
85MP0009785_altered_susceptibility_to0.98009801
86MP0003436_decreased_susceptibility_to0.95631603
87MP0001293_anophthalmia0.95448935
88MP0009053_abnormal_anal_canal0.95151025
89MP0005464_abnormal_platelet_physiology0.95127677
90MP0005000_abnormal_immune_tolerance0.94420424
91MP0000477_abnormal_intestine_morphology0.93383169
92MP0004947_skin_inflammation0.93160101
93MP0000681_abnormal_thyroid_gland0.92227513
94MP0001286_abnormal_eye_development0.88861097
95MP0002210_abnormal_sex_determination0.88212239
96MP0005501_abnormal_skin_physiology0.85321290
97MP0005075_abnormal_melanosome_morpholog0.84122551
98MP0002877_abnormal_melanocyte_morpholog0.83196748
99MP0001881_abnormal_mammary_gland0.83130994
100MP0009250_abnormal_appendicular_skeleto0.82676910
101MP0001790_abnormal_immune_system0.82672680
102MP0005387_immune_system_phenotype0.82672680
103MP0010030_abnormal_orbit_morphology0.80388292
104MP0002132_abnormal_respiratory_system0.79503593
105MP0002932_abnormal_joint_morphology0.78194193
106MP0000762_abnormal_tongue_morphology0.77418741
107MP0000049_abnormal_middle_ear0.77002200
108MP0001145_abnormal_male_reproductive0.76543553
109MP0002009_preneoplasia0.75635055
110MP0009672_abnormal_birth_weight0.75124217
111MP0001849_ear_inflammation0.74329613
112MP0001216_abnormal_epidermal_layer0.73986739
113MP0002060_abnormal_skin_morphology0.72993623
114MP0001727_abnormal_embryo_implantation0.72217303
115MP0003941_abnormal_skin_development0.72117423
116MP0000377_abnormal_hair_follicle0.72044743
117MP0003937_abnormal_limbs/digits/tail_de0.70174090
118MP0003315_abnormal_perineum_morphology0.69838903
119MP0002148_abnormal_hypersensitivity_rea0.69353788
120MP0000733_abnormal_muscle_development0.69235745
121MP0000383_abnormal_hair_follicle0.69060755
122MP0003121_genomic_imprinting0.68983350
123MP0004264_abnormal_extraembryonic_tissu0.68237189
124MP0002114_abnormal_axial_skeleton0.67534300
125MP0002092_abnormal_eye_morphology0.67477377
126MP0002938_white_spotting0.66952848
127MP0003943_abnormal_hepatobiliary_system0.66878357
128MP0001845_abnormal_inflammatory_respons0.66793136
129MP0006035_abnormal_mitochondrial_morpho0.66318901
130MP0002111_abnormal_tail_morphology0.63160043
131MP0002098_abnormal_vibrissa_morphology0.62800388
132MP0003942_abnormal_urinary_system0.61827668
133MP0000358_abnormal_cell_content/0.61024302
134MP0003938_abnormal_ear_development0.60725410
135MP0005666_abnormal_adipose_tissue0.59966239
136MP0000627_abnormal_mammary_gland0.59268856
137MP0000653_abnormal_sex_gland0.59137803

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.10581449
2Reticulocytopenia (HP:0001896)6.53871011
3Abnormal number of erythroid precursors (HP:0012131)6.34710912
4Thrombocytosis (HP:0001894)4.61090307
5Macrocytic anemia (HP:0001972)4.44223750
6Pallor (HP:0000980)4.38824518
7Colon cancer (HP:0003003)4.18194771
8Aplastic anemia (HP:0001915)3.55891362
9Microvesicular hepatic steatosis (HP:0001414)3.17228405
10IgM deficiency (HP:0002850)3.15703048
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04799605
12Abnormality of the parietal bone (HP:0002696)2.99139915
1311 pairs of ribs (HP:0000878)2.86646147
14Selective tooth agenesis (HP:0001592)2.75400498
15Oral leukoplakia (HP:0002745)2.72210602
16Chronic otitis media (HP:0000389)2.69014060
17Respiratory difficulties (HP:0002880)2.67977859
18Basal cell carcinoma (HP:0002671)2.60858913
19Birth length less than 3rd percentile (HP:0003561)2.56890026
20Broad distal phalanx of finger (HP:0009836)2.53904869
21Myelodysplasia (HP:0002863)2.52351756
22Abnormality of cochlea (HP:0000375)2.51579284
23Short middle phalanx of the 5th finger (HP:0004220)2.48919859
24Triphalangeal thumb (HP:0001199)2.48567827
25Progressive muscle weakness (HP:0003323)2.45213029
26Absent thumb (HP:0009777)2.40940438
27Recurrent bronchitis (HP:0002837)2.38549768
28Increased hepatocellular lipid droplets (HP:0006565)2.37886565
29Amaurosis fugax (HP:0100576)2.36734742
30Abnormality of reticulocytes (HP:0004312)2.34994190
31Abnormal hemoglobin (HP:0011902)2.34825001
32Poikiloderma (HP:0001029)2.32373344
33Ependymoma (HP:0002888)2.31157343
34Duplication of thumb phalanx (HP:0009942)2.27317628
35Asplenia (HP:0001746)2.25693596
36Multiple enchondromatosis (HP:0005701)2.25385480
37Partial duplication of thumb phalanx (HP:0009944)2.24977768
38Proximal placement of thumb (HP:0009623)2.23226628
39Partial duplication of the phalanx of hand (HP:0009999)2.22926527
40Medulloblastoma (HP:0002885)2.22218445
41Elevated erythrocyte sedimentation rate (HP:0003565)2.21028378
42Abnormality of small intestinal villus morphology (HP:0011472)2.18872592
43Villous atrophy (HP:0011473)2.18872592
44Microretrognathia (HP:0000308)2.17168495
45Stenosis of the external auditory canal (HP:0000402)2.16292560
46Petechiae (HP:0000967)2.15528319
47Abnormality of T cell physiology (HP:0011840)2.14951411
48Lymphoma (HP:0002665)2.14728916
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14297035
50Agammaglobulinemia (HP:0004432)2.13566721
51Trismus (HP:0000211)2.13519167
52Neoplasm of the pancreas (HP:0002894)2.12668901
53Nasolacrimal duct obstruction (HP:0000579)2.11634937
54Deviation of the thumb (HP:0009603)2.10930818
55Abnormality of T cells (HP:0002843)2.10659621
56Aplasia/Hypoplasia of the spleen (HP:0010451)2.09267656
57Recurrent viral infections (HP:0004429)2.07303165
58Abnormality of the phalanges of the hallux (HP:0010057)2.07287994
59Syringomyelia (HP:0003396)2.05804999
60Spinal cord lesions (HP:0100561)2.05804999
61Rectal prolapse (HP:0002035)2.05392664
62Depressed nasal ridge (HP:0000457)2.02659765
63Rough bone trabeculation (HP:0100670)2.01335940
64Premature skin wrinkling (HP:0100678)2.00650261
65Agnosia (HP:0010524)1.99817754
66Missing ribs (HP:0000921)1.99542459
67Entropion (HP:0000621)1.99065268
68Glossoptosis (HP:0000162)1.97911213
69Squamous cell carcinoma (HP:0002860)1.96381239
70Atresia of the external auditory canal (HP:0000413)1.96252101
71Lipid accumulation in hepatocytes (HP:0006561)1.95792305
72Horseshoe kidney (HP:0000085)1.94232204
73Acute myeloid leukemia (HP:0004808)1.93765087
74Colitis (HP:0002583)1.91807084
75Cleft eyelid (HP:0000625)1.91275488
76Progressive external ophthalmoplegia (HP:0000590)1.90604334
77Thick lower lip vermilion (HP:0000179)1.90402231
78Panhypogammaglobulinemia (HP:0003139)1.89656653
79Gout (HP:0001997)1.88564789
80Morphological abnormality of the inner ear (HP:0011390)1.86962501
81Septate vagina (HP:0001153)1.86923901
82Cellulitis (HP:0100658)1.85116279
83Calcaneovalgus deformity (HP:0001848)1.84632590
84Abnormality of DNA repair (HP:0003254)1.84233454
85Abnormal number of incisors (HP:0011064)1.83933799
86Volvulus (HP:0002580)1.83304933
87Abnormality of the anterior horn cell (HP:0006802)1.82989159
88Degeneration of anterior horn cells (HP:0002398)1.82989159
89Deep philtrum (HP:0002002)1.82085253
90Abnormality of the distal phalanx of the thumb (HP:0009617)1.80399810
91Congenital, generalized hypertrichosis (HP:0004540)1.79493720
92Abnormality of B cell number (HP:0010975)1.79184310
93B lymphocytopenia (HP:0010976)1.79184310
94Premature graying of hair (HP:0002216)1.78884670
95Prolonged bleeding time (HP:0003010)1.78721069
96Abnormality of cells of the lymphoid lineage (HP:0012140)1.78551132
97Increased density of long bones (HP:0006392)1.77949856
98Bicuspid aortic valve (HP:0001647)1.77625534
99Increased nuchal translucency (HP:0010880)1.77169773
100T lymphocytopenia (HP:0005403)1.76716311
101Lymphopenia (HP:0001888)1.76682198
102Deep palmar crease (HP:0006191)1.76300634
103Abnormality of the preputium (HP:0100587)1.76103588
104Neoplasm of the colon (HP:0100273)1.75621723
105Increased intramyocellular lipid droplets (HP:0012240)1.75598396
106Abnormality of the fingertips (HP:0001211)1.75469152
107Migraine (HP:0002076)1.75442631
108Blepharitis (HP:0000498)1.72419409
109Abnormality of chromosome stability (HP:0003220)1.72180812
110Facial cleft (HP:0002006)1.71626722
111IgG deficiency (HP:0004315)1.71262160
112Prominent nose (HP:0000448)1.70753208
113Rhabdomyosarcoma (HP:0002859)1.68860881
114Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67946450
115Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67946450
116Biliary tract neoplasm (HP:0100574)1.67863244
117Deformed tarsal bones (HP:0008119)1.67397855
118Aplasia/Hypoplasia of the thymus (HP:0010515)1.67032295
119Breast hypoplasia (HP:0003187)1.65285626
120Cellular immunodeficiency (HP:0005374)1.65182232
121Abnormal delayed hypersensitivity skin test (HP:0002963)1.64602261
122Patellar aplasia (HP:0006443)1.62809822
123Abnormality of the calcaneus (HP:0008364)1.62664633
124High pitched voice (HP:0001620)1.62040166
125Cutaneous melanoma (HP:0012056)1.61542594
126Acute lymphatic leukemia (HP:0006721)1.60869165
127High anterior hairline (HP:0009890)1.60793744
128Lip pit (HP:0100267)1.59871759
129Abnormality of T cell number (HP:0011839)1.59671375
130Carpal bone hypoplasia (HP:0001498)1.59108429
131Abnormality of the renal collecting system (HP:0004742)1.59078147
132Pancytopenia (HP:0001876)1.58803358
133Hypoplasia of the radius (HP:0002984)1.58647794
134Nasal polyposis (HP:0100582)1.58631134
135Testicular atrophy (HP:0000029)1.58557892
136Abnormality of the nasal mucosa (HP:0000433)1.58468550
137Myositis (HP:0100614)1.58322146
138Gastrointestinal inflammation (HP:0004386)1.58127074
139Optic nerve coloboma (HP:0000588)1.57495994
140Abnormality of the lacrimal duct (HP:0011481)1.57453689
141Chromsome breakage (HP:0040012)1.56339095
142Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.56131179
143Short 4th metacarpal (HP:0010044)1.56131179
144Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.56066102
145Premature ovarian failure (HP:0008209)1.55337649
146Tracheoesophageal fistula (HP:0002575)1.54231968
147Viral hepatitis (HP:0006562)1.52574839
148Delayed cranial suture closure (HP:0000270)1.52327810
149Duplicated collecting system (HP:0000081)1.48346263
150Abnormality of the nasolacrimal system (HP:0000614)1.45963449
151Inflammation of the large intestine (HP:0002037)1.45821731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.97017989
2NME23.46416978
3SMG13.36724476
4WEE13.09829258
5CDC72.82425076
6VRK22.79329262
7TGFBR12.77189109
8RPS6KB22.74999990
9PASK2.67600931
10BUB12.44188894
11MAP4K12.38941620
12PKN22.28152047
13NEK22.23421547
14LRRK22.18845693
15FLT32.15549586
16PRPF4B1.95630882
17TAF11.90427875
18RPS6KA41.87813824
19PBK1.79340445
20TSSK61.76670463
21MAP3K101.70435992
22DYRK31.63414514
23ACVR1B1.60431506
24STK101.55106367
25EIF2AK11.51370340
26BRSK21.48293530
27MKNK11.47376349
28SCYL21.43788978
29SRPK11.42669633
30BTK1.41133201
31AURKB1.40621448
32MAP2K31.32788028
33CDK71.32774859
34KIT1.30672961
35VRK11.29352928
36CDK41.26912702
37TRIB31.26692873
38ATR1.24189640
39MAPKAPK31.18590884
40PAK41.16994789
41ZAP701.16641025
42JAK31.16346114
43TEC1.16226879
44STK161.15176096
45EIF2AK31.14390431
46MAP3K81.13207067
47PIM21.09522506
48PIM11.08460288
49TTK1.06810142
50PLK11.05556785
51TLK11.03988172
52CDK61.01466503
53NEK11.01315447
54CSF1R0.99130527
55TESK20.95578834
56STK240.95031066
57ILK0.93699644
58NME10.89561571
59MST40.86866791
60TGFBR20.86634447
61IRAK40.86017725
62CDK120.85071892
63GRK60.84149275
64IRAK30.81216091
65STK40.81156454
66TYK20.80915591
67CDK190.80327961
68NLK0.78445359
69BRAF0.77740051
70KDR0.77003097
71MAP3K30.75408235
72CHEK10.75174788
73MAP3K130.74273507
74CDK30.72933274
75ALK0.70050979
76ICK0.67039161
77PAK20.66437426
78ZAK0.65363840
79IKBKB0.64111786
80SYK0.63793112
81MKNK20.63298419
82CHEK20.61506770
83ITK0.61430855
84MAP2K20.61191386
85PLK30.60031891
86CSNK2A20.58835095
87EPHA20.58589909
88BLK0.58359193
89TBK10.58300342
90LCK0.54842830
91CDK90.54685421
92MAP3K140.52760755
93PLK40.52461115
94ATM0.52407215
95CDK80.52296563
96AURKA0.52197557
97ERN10.50216653
98RPS6KA50.49847858
99PTK60.49844427
100TTN0.49178525
101CDK20.48835722
102TXK0.46641988
103BRSK10.45555185
104RPS6KB10.45315284
105CDK10.44965956
106CSNK2A10.43940252
107EIF2AK20.43210380
108FGFR40.42960041
109LYN0.42620225
110BRD40.42515652
111CCNB10.41514545
112MELK0.40271698
113IRAK20.39136179
114NUAK10.38173445
115AKT20.37983596
116RPS6KA10.37406870
117MAPKAPK20.36882939
118RPS6KA60.35308825
119IKBKE0.35132943
120PAK10.34383846
121CLK10.33635924
122RPS6KC10.32436791
123RPS6KL10.32436791
124MATK0.32328086
125PNCK0.31517550
126CDK11A0.31350408
127CSNK1E0.29546069
128STK30.29165582
129HIPK20.27840958
130MARK30.27186529
131DAPK30.27056382

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.84096278
2DNA replication_Homo sapiens_hsa030304.41946470
3Mismatch repair_Homo sapiens_hsa034303.68882136
4Spliceosome_Homo sapiens_hsa030403.00700138
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69763297
6Base excision repair_Homo sapiens_hsa034102.64793128
7RNA transport_Homo sapiens_hsa030132.53318075
8Nucleotide excision repair_Homo sapiens_hsa034202.46004419
9Proteasome_Homo sapiens_hsa030502.39714572
10RNA polymerase_Homo sapiens_hsa030202.32728903
11Homologous recombination_Homo sapiens_hsa034402.31687929
12Cell cycle_Homo sapiens_hsa041102.16027376
13One carbon pool by folate_Homo sapiens_hsa006702.06971068
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00887114
15Pyrimidine metabolism_Homo sapiens_hsa002401.97090224
16Non-homologous end-joining_Homo sapiens_hsa034501.89910717
17Primary immunodeficiency_Homo sapiens_hsa053401.66541282
18RNA degradation_Homo sapiens_hsa030181.60114212
19Parkinsons disease_Homo sapiens_hsa050121.56524635
20Oxidative phosphorylation_Homo sapiens_hsa001901.56371594
21p53 signaling pathway_Homo sapiens_hsa041151.54597861
22Antigen processing and presentation_Homo sapiens_hsa046121.51051761
23Fanconi anemia pathway_Homo sapiens_hsa034601.49982173
24mRNA surveillance pathway_Homo sapiens_hsa030151.34168844
25Huntingtons disease_Homo sapiens_hsa050161.34042531
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28437412
27Herpes simplex infection_Homo sapiens_hsa051681.26480419
28Epstein-Barr virus infection_Homo sapiens_hsa051691.16987424
29Systemic lupus erythematosus_Homo sapiens_hsa053221.14168262
30Basal transcription factors_Homo sapiens_hsa030221.11333080
31Viral carcinogenesis_Homo sapiens_hsa052031.08003191
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03219372
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00623113
34HTLV-I infection_Homo sapiens_hsa051660.99575498
35Small cell lung cancer_Homo sapiens_hsa052220.98349044
36Hematopoietic cell lineage_Homo sapiens_hsa046400.94860753
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93618799
38Legionellosis_Homo sapiens_hsa051340.93398476
39Measles_Homo sapiens_hsa051620.91952386
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.90122549
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.89217772
42Purine metabolism_Homo sapiens_hsa002300.88866388
43Thyroid cancer_Homo sapiens_hsa052160.88674229
44Chronic myeloid leukemia_Homo sapiens_hsa052200.84817442
45B cell receptor signaling pathway_Homo sapiens_hsa046620.84544296
46Alzheimers disease_Homo sapiens_hsa050100.83062804
47Protein export_Homo sapiens_hsa030600.82338940
48Acute myeloid leukemia_Homo sapiens_hsa052210.74413468
49Apoptosis_Homo sapiens_hsa042100.74269829
50Hepatitis B_Homo sapiens_hsa051610.72923820
51N-Glycan biosynthesis_Homo sapiens_hsa005100.71734297
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.70828107
53Autoimmune thyroid disease_Homo sapiens_hsa053200.70287639
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.70276008
55MicroRNAs in cancer_Homo sapiens_hsa052060.70133338
56Sulfur relay system_Homo sapiens_hsa041220.69838085
57Shigellosis_Homo sapiens_hsa051310.69786241
58Leishmaniasis_Homo sapiens_hsa051400.68114802
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.65146051
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63630103
61Notch signaling pathway_Homo sapiens_hsa043300.63592928
62Colorectal cancer_Homo sapiens_hsa052100.62783937
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61817070
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61208571
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61155372
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60966756
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60947360
68Folate biosynthesis_Homo sapiens_hsa007900.60330888
69Pentose phosphate pathway_Homo sapiens_hsa000300.60315350
70Carbon metabolism_Homo sapiens_hsa012000.59780758
71T cell receptor signaling pathway_Homo sapiens_hsa046600.58964030
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.57778265
73Toxoplasmosis_Homo sapiens_hsa051450.55311176
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52471247
75Platelet activation_Homo sapiens_hsa046110.51781253
76Influenza A_Homo sapiens_hsa051640.51665915
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49606134
78Viral myocarditis_Homo sapiens_hsa054160.49476389
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48174980
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47893096
81Selenocompound metabolism_Homo sapiens_hsa004500.47022943
82Basal cell carcinoma_Homo sapiens_hsa052170.46871585
83Pathways in cancer_Homo sapiens_hsa052000.46021638
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45756424
85Non-small cell lung cancer_Homo sapiens_hsa052230.45726804
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45714741
87Bladder cancer_Homo sapiens_hsa052190.44511618
88Pancreatic cancer_Homo sapiens_hsa052120.43460594
89HIF-1 signaling pathway_Homo sapiens_hsa040660.42798464
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42120767
91TGF-beta signaling pathway_Homo sapiens_hsa043500.42074455
92Pyruvate metabolism_Homo sapiens_hsa006200.41410469
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40836611
94Osteoclast differentiation_Homo sapiens_hsa043800.40687319
95Graft-versus-host disease_Homo sapiens_hsa053320.39963991
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.38623296
97Renal cell carcinoma_Homo sapiens_hsa052110.38421860
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.38160991
99Proteoglycans in cancer_Homo sapiens_hsa052050.37867745
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36974256
101Alcoholism_Homo sapiens_hsa050340.36895601
102mTOR signaling pathway_Homo sapiens_hsa041500.36166870
103Oocyte meiosis_Homo sapiens_hsa041140.36114355
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35190408
105Allograft rejection_Homo sapiens_hsa053300.34555867
106Biosynthesis of amino acids_Homo sapiens_hsa012300.33317979
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33171274
108Asthma_Homo sapiens_hsa053100.30404855
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29537900
110Hippo signaling pathway_Homo sapiens_hsa043900.28550246
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27811133
112TNF signaling pathway_Homo sapiens_hsa046680.27780262
113Glutathione metabolism_Homo sapiens_hsa004800.27700814
114Prostate cancer_Homo sapiens_hsa052150.27134898
115Adherens junction_Homo sapiens_hsa045200.25872281
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25637800
117Wnt signaling pathway_Homo sapiens_hsa043100.24380803
118Endometrial cancer_Homo sapiens_hsa052130.23842682
119Melanoma_Homo sapiens_hsa052180.23535205
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23307657
121Hedgehog signaling pathway_Homo sapiens_hsa043400.23040688
122Type I diabetes mellitus_Homo sapiens_hsa049400.21688009
123Lysine degradation_Homo sapiens_hsa003100.21161659
124VEGF signaling pathway_Homo sapiens_hsa043700.19463326
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.18876637

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