RPS4XP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)9.01120567
2viral transcription (GO:0019083)7.91577395
3ribosomal small subunit biogenesis (GO:0042274)7.67607457
4translational termination (GO:0006415)7.49260581
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.92341270
6ATP synthesis coupled proton transport (GO:0015986)6.92341270
7translational elongation (GO:0006414)6.53405476
8ribosomal small subunit assembly (GO:0000028)6.51097577
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.46142581
10cotranslational protein targeting to membrane (GO:0006613)6.36844644
11protein targeting to ER (GO:0045047)6.36115978
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.06736285
13protein localization to endoplasmic reticulum (GO:0070972)5.97075509
14viral life cycle (GO:0019058)5.86320439
15cellular protein complex disassembly (GO:0043624)5.74933728
16establishment of protein localization to mitochondrial membrane (GO:0090151)5.62187094
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.61047471
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.47748190
19maturation of SSU-rRNA (GO:0030490)5.47188004
20neurofilament cytoskeleton organization (GO:0060052)5.26274105
21DNA deamination (GO:0045006)4.86601646
22translational initiation (GO:0006413)4.84922307
23protein complex disassembly (GO:0043241)4.76599607
24behavioral response to nicotine (GO:0035095)4.50025168
25macromolecular complex disassembly (GO:0032984)4.44314377
26protein targeting to membrane (GO:0006612)4.40715504
27translation (GO:0006412)4.27030938
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16422265
29respiratory electron transport chain (GO:0022904)4.13364837
30ribosomal large subunit biogenesis (GO:0042273)4.10805501
31ATP biosynthetic process (GO:0006754)4.10770893
32electron transport chain (GO:0022900)4.09448967
33purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.07643791
34protein neddylation (GO:0045116)4.01048530
35purine nucleoside triphosphate biosynthetic process (GO:0009145)3.99922578
36GTP biosynthetic process (GO:0006183)3.97741299
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.95953123
38protein-cofactor linkage (GO:0018065)3.84566340
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80065725
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80065725
41protein complex biogenesis (GO:0070271)3.75315078
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.73319464
43NADH dehydrogenase complex assembly (GO:0010257)3.73319464
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.73319464
45mRNA catabolic process (GO:0006402)3.70963497
46ribonucleoprotein complex biogenesis (GO:0022613)3.68435039
47cellular component biogenesis (GO:0044085)3.67952885
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.56463068
49ribonucleoside triphosphate biosynthetic process (GO:0009201)3.52550751
50regulation of DNA methylation (GO:0044030)3.50897462
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46580448
52hydrogen ion transmembrane transport (GO:1902600)3.44157009
53intracellular protein transmembrane import (GO:0044743)3.41384384
54mitochondrial respiratory chain complex assembly (GO:0033108)3.40109384
55UTP biosynthetic process (GO:0006228)3.36576112
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34432738
57RNA catabolic process (GO:0006401)3.33383164
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25041478
59GDP-mannose metabolic process (GO:0019673)3.19508744
60UTP metabolic process (GO:0046051)3.19431415
61glyoxylate metabolic process (GO:0046487)3.15852352
62inner mitochondrial membrane organization (GO:0007007)3.12910429
63proton transport (GO:0015992)3.09390702
64protein targeting to mitochondrion (GO:0006626)3.03638515
65hydrogen transport (GO:0006818)3.03358215
66establishment of protein localization to membrane (GO:0090150)3.01748041
67nucleoside triphosphate biosynthetic process (GO:0009142)2.99747891
68viral protein processing (GO:0019082)2.95473668
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93946446
70protein targeting (GO:0006605)2.93761761
71positive regulation of fatty acid transport (GO:2000193)2.90589127
72interferon-gamma production (GO:0032609)2.88525875
73positive regulation of T cell apoptotic process (GO:0070234)2.87328666
74guanosine-containing compound biosynthetic process (GO:1901070)2.86451543
75cardiovascular system development (GO:0072358)2.85950225
76negative regulation of T cell differentiation in thymus (GO:0033085)2.83735411
77establishment of protein localization to mitochondrion (GO:0072655)2.83708891
78signal peptide processing (GO:0006465)2.81075231
79male meiosis (GO:0007140)2.80425884
80positive regulation of icosanoid secretion (GO:0032305)2.80143992
81nucleoside transmembrane transport (GO:1901642)2.73388503
82cytidine catabolic process (GO:0006216)2.70439872
83cytidine deamination (GO:0009972)2.70439872
84cytidine metabolic process (GO:0046087)2.70439872
85CTP metabolic process (GO:0046036)2.66526720
86CTP biosynthetic process (GO:0006241)2.66526720
87regulation of cilium movement (GO:0003352)2.65609233
88rRNA processing (GO:0006364)2.63729227
89pyrimidine nucleotide catabolic process (GO:0006244)2.63452692
90establishment of protein localization to organelle (GO:0072594)2.63434777
91rRNA metabolic process (GO:0016072)2.59898542
92protein localization to mitochondrion (GO:0070585)2.59799094
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.56622010
94cytochrome complex assembly (GO:0017004)2.53079561
95positive regulation of prostaglandin secretion (GO:0032308)2.50618704
96pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.48549698
97pseudouridine synthesis (GO:0001522)2.43983905
98mitochondrial transport (GO:0006839)2.43717427
99negative regulation of response to food (GO:0032096)2.42536520
100negative regulation of appetite (GO:0032099)2.42536520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.19227585
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.01415975
3EZH2_22144423_ChIP-Seq_EOC_Human4.00646224
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.53078193
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.92458385
6VDR_22108803_ChIP-Seq_LS180_Human2.91293026
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.89558739
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73962382
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73548611
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66194014
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62810131
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.61782347
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57366099
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.26306916
15IRF1_19129219_ChIP-ChIP_H3396_Human2.24596226
16ZNF274_21170338_ChIP-Seq_K562_Hela2.09824020
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96471755
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96419781
19YY1_21170310_ChIP-Seq_MESCs_Mouse1.90268070
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89214978
21VDR_23849224_ChIP-Seq_CD4+_Human1.83742912
22FOXP3_21729870_ChIP-Seq_TREG_Human1.76642430
23IGF1R_20145208_ChIP-Seq_DFB_Human1.70867782
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61391301
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57350840
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.54282032
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53859938
28TP53_22573176_ChIP-Seq_HFKS_Human1.51555199
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.51498968
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51143397
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49819450
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49370954
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.47521707
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43060861
35XRN2_22483619_ChIP-Seq_HELA_Human1.42805143
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41580430
37TAF2_19829295_ChIP-Seq_ESCs_Human1.36460221
38TTF2_22483619_ChIP-Seq_HELA_Human1.34741705
39NANOG_20526341_ChIP-Seq_ESCs_Human1.34684711
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33530067
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32979488
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31962104
43ERA_21632823_ChIP-Seq_H3396_Human1.31188477
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28832049
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27895149
46CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.27852177
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27422136
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26922208
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.26120325
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25923918
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.20862483
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.20572826
53SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20364904
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20088871
55BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19444887
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18904442
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.18836983
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18464377
59FOXH1_21741376_ChIP-Seq_ESCs_Human1.16637074
60GABP_19822575_ChIP-Seq_HepG2_Human1.16620906
61MYC_18940864_ChIP-ChIP_HL60_Human1.16310721
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16179878
63E2F1_20622854_ChIP-Seq_HELA_Human1.15987139
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.15936067
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15746721
66SA1_27219007_Chip-Seq_Bcells_Human1.14373200
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14364083
68BCL6_27268052_Chip-Seq_Bcells_Human1.13093833
69CTCF_20526341_ChIP-Seq_ESCs_Human1.12861097
70NCOR_22424771_ChIP-Seq_293T_Human1.11683171
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10992822
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09852845
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.09661952
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09403226
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07961362
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07355966
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06309392
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05540942
79RNF2_27304074_Chip-Seq_NSC_Mouse1.05493994
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05237736
81ELK1_19687146_ChIP-ChIP_HELA_Human1.04952012
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04641118
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.03623795
84EED_16625203_ChIP-ChIP_MESCs_Mouse1.01090394
85P53_21459846_ChIP-Seq_SAOS-2_Human1.00435478
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.00320733
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00174341
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99506159
89MYC_19829295_ChIP-Seq_ESCs_Human0.98560183
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.97481231
91REST_21632747_ChIP-Seq_MESCs_Mouse0.94398249
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93939218
93FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93552295
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.93552295
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92950684
96CTCF_27219007_Chip-Seq_Bcells_Human0.92767829
97STAT1_20625510_ChIP-Seq_HELA_Human0.91967408
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.91740976
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.91630803
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90348589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.22433424
2MP0003646_muscle_fatigue3.06754880
3MP0002638_abnormal_pupillary_reflex2.75475507
4MP0008995_early_reproductive_senescence2.75032817
5MP0005671_abnormal_response_to2.70063402
6MP0006292_abnormal_olfactory_placode2.60856540
7MP0004885_abnormal_endolymph2.56091151
8MP0002163_abnormal_gland_morphology2.32324701
9MP0006072_abnormal_retinal_apoptosis2.11444628
10MP0004145_abnormal_muscle_electrophysio2.01607653
11MP0003878_abnormal_ear_physiology1.97282884
12MP0005377_hearing/vestibular/ear_phenot1.97282884
13MP0002876_abnormal_thyroid_physiology1.97220704
14MP0001986_abnormal_taste_sensitivity1.93072424
15MP0008875_abnormal_xenobiotic_pharmacok1.83214805
16MP0001188_hyperpigmentation1.75932580
17MP0004142_abnormal_muscle_tone1.73993027
18MP0001968_abnormal_touch/_nociception1.66635750
19MP0004147_increased_porphyrin_level1.63947007
20MP0001529_abnormal_vocalization1.60015947
21MP0008789_abnormal_olfactory_epithelium1.58852199
22MP0002837_dystrophic_cardiac_calcinosis1.56170907
23MP0005646_abnormal_pituitary_gland1.55125779
24MP0000372_irregular_coat_pigmentation1.53873246
25MP0006276_abnormal_autonomic_nervous1.51496395
26MP0002822_catalepsy1.50447276
27MP0005645_abnormal_hypothalamus_physiol1.45198176
28MP0002160_abnormal_reproductive_system1.43929769
29MP0003011_delayed_dark_adaptation1.42408781
30MP0002736_abnormal_nociception_after1.40885733
31MP0003786_premature_aging1.39379763
32MP0003186_abnormal_redox_activity1.38249689
33MP0005551_abnormal_eye_electrophysiolog1.35040083
34MP0001835_abnormal_antigen_presentation1.34926218
35MP0005389_reproductive_system_phenotype1.34477130
36MP0002653_abnormal_ependyma_morphology1.32087268
37MP0004858_abnormal_nervous_system1.32075703
38MP0008872_abnormal_physiological_respon1.29171298
39MP0004742_abnormal_vestibular_system1.27718251
40MP0003806_abnormal_nucleotide_metabolis1.27680000
41MP0003787_abnormal_imprinting1.26460382
42MP0001905_abnormal_dopamine_level1.25557379
43MP0004043_abnormal_pH_regulation1.23458196
44MP0009333_abnormal_splenocyte_physiolog1.21148693
45MP0005387_immune_system_phenotype1.18489307
46MP0001790_abnormal_immune_system1.18489307
47MP0002095_abnormal_skin_pigmentation1.18421934
48MP0002102_abnormal_ear_morphology1.17547438
49MP0005499_abnormal_olfactory_system1.16618465
50MP0005394_taste/olfaction_phenotype1.16618465
51MP0002272_abnormal_nervous_system1.16409381
52MP0003879_abnormal_hair_cell1.16342810
53MP0008877_abnormal_DNA_methylation1.14342223
54MP0009745_abnormal_behavioral_response1.11115634
55MP0001440_abnormal_grooming_behavior1.10972704
56MP0001873_stomach_inflammation1.10836803
57MP0002277_abnormal_respiratory_mucosa1.10804650
58MP0005379_endocrine/exocrine_gland_phen1.08574166
59MP0001919_abnormal_reproductive_system1.04694830
60MP0005360_urolithiasis1.01614852
61MP0001800_abnormal_humoral_immune1.00906981
62MP0005084_abnormal_gallbladder_morpholo0.99843210
63MP0009046_muscle_twitch0.99247177
64MP0001542_abnormal_bone_strength0.97701322
65MP0001970_abnormal_pain_threshold0.97440068
66MP0005253_abnormal_eye_physiology0.95454607
67MP0005423_abnormal_somatic_nervous0.94948158
68MP0009764_decreased_sensitivity_to0.93402043
69MP0005195_abnormal_posterior_eye0.93150025
70MP0001485_abnormal_pinna_reflex0.92043369
71MP0000049_abnormal_middle_ear0.87969266
72MP0002723_abnormal_immune_serum0.86684369
73MP0002733_abnormal_thermal_nociception0.85717947
74MP0002735_abnormal_chemical_nociception0.85566315
75MP0006036_abnormal_mitochondrial_physio0.85205608
76MP0009250_abnormal_appendicular_skeleto0.85070459
77MP0002210_abnormal_sex_determination0.85047928
78MP0002557_abnormal_social/conspecific_i0.84735691
79MP0008775_abnormal_heart_ventricle0.83769078
80MP0001663_abnormal_digestive_system0.81850766
81MP0005075_abnormal_melanosome_morpholog0.80650749
82MP0001119_abnormal_female_reproductive0.80078668
83MP0005000_abnormal_immune_tolerance0.78541889
84MP0003763_abnormal_thymus_physiology0.78455159
85MP0003436_decreased_susceptibility_to0.78195074
86MP0000631_abnormal_neuroendocrine_gland0.77582695
87MP0002938_white_spotting0.77501349
88MP0003866_abnormal_defecation0.76856635
89MP0000685_abnormal_immune_system0.76371291
90MP0001984_abnormal_olfaction0.76026627
91MP0002752_abnormal_somatic_nervous0.75155908
92MP0002148_abnormal_hypersensitivity_rea0.74566056
93MP0009785_altered_susceptibility_to0.74198289
94MP0005085_abnormal_gallbladder_physiolo0.73743893
95MP0002420_abnormal_adaptive_immunity0.73194668
96MP0005025_abnormal_response_to0.71803460
97MP0006082_CNS_inflammation0.71134115
98MP0004133_heterotaxia0.70931368
99MP0001819_abnormal_immune_cell0.70628188
100MP0002572_abnormal_emotion/affect_behav0.69148120

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.09434968
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.76621499
3Acute necrotizing encephalopathy (HP:0006965)4.42221441
4Mitochondrial inheritance (HP:0001427)4.00212267
5Abnormal mitochondria in muscle tissue (HP:0008316)3.99622723
6Pallor (HP:0000980)3.94115036
7Abnormality of cells of the erythroid lineage (HP:0012130)3.91447639
8Acute encephalopathy (HP:0006846)3.88092527
9Increased hepatocellular lipid droplets (HP:0006565)3.74248940
10Increased CSF lactate (HP:0002490)3.63724940
11Progressive macrocephaly (HP:0004481)3.59483361
12Abnormal rod and cone electroretinograms (HP:0008323)3.51122879
13Lipid accumulation in hepatocytes (HP:0006561)3.40990988
14Macrocytic anemia (HP:0001972)3.33393182
15Increased intramyocellular lipid droplets (HP:0012240)3.32711630
16Renal Fanconi syndrome (HP:0001994)3.27602013
17Absent thumb (HP:0009777)3.20580680
18Decreased central vision (HP:0007663)3.15498988
193-Methylglutaconic aciduria (HP:0003535)3.04288748
20Abnormal hemoglobin (HP:0011902)3.01242320
21Abnormal number of erythroid precursors (HP:0012131)3.00619627
22Abnormality of the renal collecting system (HP:0004742)3.00290619
23Aplastic anemia (HP:0001915)2.98642063
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96503884
25Duplicated collecting system (HP:0000081)2.96318640
26Hepatocellular necrosis (HP:0001404)2.94609106
27Congenital stationary night blindness (HP:0007642)2.92144725
28Elevated erythrocyte sedimentation rate (HP:0003565)2.88036601
29Cerebral edema (HP:0002181)2.87321058
30Abnormality of DNA repair (HP:0003254)2.84286039
31Increased muscle lipid content (HP:0009058)2.81742567
32Hepatic necrosis (HP:0002605)2.78091046
33Pendular nystagmus (HP:0012043)2.75517745
34Optic disc pallor (HP:0000543)2.59434229
35Exertional dyspnea (HP:0002875)2.59055798
36Increased serum lactate (HP:0002151)2.48620558
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43826886
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43826886
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.42511576
40Hyperglycinemia (HP:0002154)2.38224152
41Acanthocytosis (HP:0001927)2.35985165
42Abnormality of midbrain morphology (HP:0002418)2.35342851
43Molar tooth sign on MRI (HP:0002419)2.35342851
44Agitation (HP:0000713)2.35032684
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34124476
46Lactic acidosis (HP:0003128)2.32684064
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.31780635
48Renal cortical cysts (HP:0000803)2.23780501
49Ectopic kidney (HP:0000086)2.17291894
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.17152813
51Microretrognathia (HP:0000308)2.13863569
52Pancreatic cysts (HP:0001737)2.11681429
53Glycosuria (HP:0003076)2.10548941
54Abnormality of urine glucose concentration (HP:0011016)2.10548941
55Oral leukoplakia (HP:0002745)2.10079344
56Medial flaring of the eyebrow (HP:0010747)2.10012952
57Abnormality of renal resorption (HP:0011038)2.09226078
58Pancreatic fibrosis (HP:0100732)2.08652756
59Type II lissencephaly (HP:0007260)2.08509701
60Abnormality of pyrimidine metabolism (HP:0004353)2.03471100
61Methylmalonic acidemia (HP:0002912)2.03407393
62Pancytopenia (HP:0001876)2.01496198
63Respiratory difficulties (HP:0002880)1.98959362
64Hyperphosphaturia (HP:0003109)1.93891983
65Delayed CNS myelination (HP:0002188)1.93606514
66Chromsome breakage (HP:0040012)1.93124925
67Thyroid-stimulating hormone excess (HP:0002925)1.92830275
68Dyskinesia (HP:0100660)1.90799298
69Duplication of thumb phalanx (HP:0009942)1.90015985
70Exercise intolerance (HP:0003546)1.89618630
71Methylmalonic aciduria (HP:0012120)1.89548882
72Increased IgM level (HP:0003496)1.88230245
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87986010
74Abnormality of alanine metabolism (HP:0010916)1.87986010
75Hyperalaninemia (HP:0003348)1.87986010
76Respiratory failure (HP:0002878)1.87017753
77Keratoconus (HP:0000563)1.86054830
78Increased corneal curvature (HP:0100692)1.86054830
79Attenuation of retinal blood vessels (HP:0007843)1.84871248
80Partial duplication of the phalanx of hand (HP:0009999)1.84167505
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83775715
82Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82796962
83Gastrointestinal infarctions (HP:0005244)1.82456512
84Lethargy (HP:0001254)1.82034177
85IgG deficiency (HP:0004315)1.81880683
86Type 2 muscle fiber atrophy (HP:0003554)1.81609109
87Leukodystrophy (HP:0002415)1.80246836
88Stenosis of the external auditory canal (HP:0000402)1.79318351
89Abnormality of the renal cortex (HP:0011035)1.78516903
90True hermaphroditism (HP:0010459)1.78478728
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.76047454
92Congenital, generalized hypertrichosis (HP:0004540)1.72455731
93Stomatitis (HP:0010280)1.71651477
94Absent/shortened dynein arms (HP:0200106)1.70711823
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.70711823
96Abnormality of reticulocytes (HP:0004312)1.67810703
97Dysphonia (HP:0001618)1.66346311
98Gait imbalance (HP:0002141)1.65733957
99Abnormality of eosinophils (HP:0001879)1.65576488
100Muscle fiber atrophy (HP:0100295)1.65419912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.80727363
2TXK5.08630417
3MAP4K14.52732223
4NME23.49450788
5BCKDK3.19018979
6WNK42.10262374
7MAP4K22.03507150
8GRK11.97586434
9ADRBK21.96038751
10ZAK1.84319395
11TESK21.76503660
12NUAK11.68156144
13DYRK21.54479203
14TLK11.52050803
15WNK31.30044979
16AKT31.27756619
17PDK21.26100858
18STK161.25264807
19ITK1.13463988
20IKBKB1.13305838
21PINK11.10333739
22TIE11.07742691
23PIK3CA1.07576764
24CDK191.02207047
25LRRK20.97211935
26FES0.95905148
27LIMK10.92929270
28PRKCQ0.91677220
29GRK70.89266008
30LCK0.88184506
31INSRR0.86871657
32SYK0.84006374
33PLK40.82877733
34CAMKK20.79799503
35ABL20.79466487
36STK390.78264734
37GRK60.78126689
38PRKCG0.77910941
39BTK0.77730118
40RPS6KA50.76731432
41FRK0.75936534
42MAP2K60.75922187
43KDR0.75452097
44TEC0.75066559
45OXSR10.74775560
46ADRBK10.74747653
47RPS6KA60.72356784
48BRAF0.71691719
49PHKG10.69713197
50PHKG20.69713197
51IKBKE0.68357546
52NME10.67663265
53OBSCN0.67066579
54PRKACA0.62426768
55PIM10.62129959
56MUSK0.60583661
57KIT0.60012680
58BMPR20.58951494
59MAP2K20.58489102
60CSNK2A20.58326250
61MAP3K110.54917558
62MATK0.54500647
63LYN0.52865517
64CAMK10.52781416
65ZAP700.51776850
66CSNK2A10.51679317
67RPS6KL10.51293257
68RPS6KC10.51293257
69DYRK1B0.50733778
70SGK10.50140956
71MAPK130.48900287
72VRK20.48289686
73NTRK20.46976573
74PRKCA0.46866911
75PRKCD0.46653867
76AURKA0.46294547
77NEK10.45442769
78MAPK150.44825543
79CAMK2A0.44168576
80RIPK40.44081100
81EPHB20.43470230
82MINK10.42243374
83RPS6KA10.42150446
84MAP2K70.41963445
85ATR0.41178703
86TNK20.37214664
87DAPK30.36076938
88PRKACG0.36049072
89CSNK1A10.34342044
90MAP3K40.33373285
91CDC70.33006365
92PKN10.32672733
93MARK10.31555026
94PRKCH0.31058607
95VRK10.31010872
96AURKB0.30250123
97IGF1R0.29818077
98FYN0.29487318
99STK110.28446091
100CSF1R0.28054853

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.40420189
2Oxidative phosphorylation_Homo sapiens_hsa001904.26147476
3Parkinsons disease_Homo sapiens_hsa050123.45207522
4Asthma_Homo sapiens_hsa053102.85596025
5Alzheimers disease_Homo sapiens_hsa050102.39779308
6Cardiac muscle contraction_Homo sapiens_hsa042602.35584834
7Allograft rejection_Homo sapiens_hsa053302.34657244
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.30955170
9Autoimmune thyroid disease_Homo sapiens_hsa053202.26061132
10Huntingtons disease_Homo sapiens_hsa050162.23923704
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.10148456
12Proteasome_Homo sapiens_hsa030502.05740086
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00372850
14RNA polymerase_Homo sapiens_hsa030201.92602450
15Graft-versus-host disease_Homo sapiens_hsa053321.91312661
16Linoleic acid metabolism_Homo sapiens_hsa005911.89098527
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87450588
18Protein export_Homo sapiens_hsa030601.81090160
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73065593
20Type I diabetes mellitus_Homo sapiens_hsa049401.60711222
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59240973
22One carbon pool by folate_Homo sapiens_hsa006701.47821817
23Phototransduction_Homo sapiens_hsa047441.47297304
24RNA degradation_Homo sapiens_hsa030181.44185710
25Sulfur metabolism_Homo sapiens_hsa009201.38443173
26Primary immunodeficiency_Homo sapiens_hsa053401.37895701
27Sulfur relay system_Homo sapiens_hsa041221.34663232
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19088518
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16685883
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15284821
31Nitrogen metabolism_Homo sapiens_hsa009101.09138237
32Ether lipid metabolism_Homo sapiens_hsa005651.06523956
33Pyrimidine metabolism_Homo sapiens_hsa002401.05476201
34Fanconi anemia pathway_Homo sapiens_hsa034601.00884744
35Nicotine addiction_Homo sapiens_hsa050331.00568764
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96914815
37Arachidonic acid metabolism_Homo sapiens_hsa005900.94652042
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93852293
39Basal transcription factors_Homo sapiens_hsa030220.91161003
40Fat digestion and absorption_Homo sapiens_hsa049750.89478200
41Homologous recombination_Homo sapiens_hsa034400.88740074
42Rheumatoid arthritis_Homo sapiens_hsa053230.85619617
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84510620
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83507118
45Olfactory transduction_Homo sapiens_hsa047400.82706531
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81162046
47Purine metabolism_Homo sapiens_hsa002300.77721286
48Tryptophan metabolism_Homo sapiens_hsa003800.76743388
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.76244985
50Propanoate metabolism_Homo sapiens_hsa006400.73261957
51Antigen processing and presentation_Homo sapiens_hsa046120.71358091
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71118541
53Hematopoietic cell lineage_Homo sapiens_hsa046400.70997991
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70472630
55Mismatch repair_Homo sapiens_hsa034300.69151035
56Metabolic pathways_Homo sapiens_hsa011000.68751442
57Caffeine metabolism_Homo sapiens_hsa002320.66685107
58DNA replication_Homo sapiens_hsa030300.64553152
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63981204
60Morphine addiction_Homo sapiens_hsa050320.58947335
61Staphylococcus aureus infection_Homo sapiens_hsa051500.58501029
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58058910
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56943145
64Retinol metabolism_Homo sapiens_hsa008300.56810507
65Chemical carcinogenesis_Homo sapiens_hsa052040.56280616
66Nucleotide excision repair_Homo sapiens_hsa034200.53603249
67Peroxisome_Homo sapiens_hsa041460.52051640
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50730411
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49030298
70Collecting duct acid secretion_Homo sapiens_hsa049660.49027214
71Pyruvate metabolism_Homo sapiens_hsa006200.47399949
72Base excision repair_Homo sapiens_hsa034100.46820234
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46711845
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46547223
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.46103527
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45068556
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.44562815
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.42402489
79Butanoate metabolism_Homo sapiens_hsa006500.40874359
80Selenocompound metabolism_Homo sapiens_hsa004500.40723698
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.40050616
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40049017
83Systemic lupus erythematosus_Homo sapiens_hsa053220.39173459
84T cell receptor signaling pathway_Homo sapiens_hsa046600.38479009
85Viral myocarditis_Homo sapiens_hsa054160.37764213
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37510592
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37015506
88Spliceosome_Homo sapiens_hsa030400.36535191
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35501812
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34124233
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33426679
92Mineral absorption_Homo sapiens_hsa049780.33238950
93Malaria_Homo sapiens_hsa051440.33042129
94Salivary secretion_Homo sapiens_hsa049700.32612496
95Tyrosine metabolism_Homo sapiens_hsa003500.29628967
96Vitamin digestion and absorption_Homo sapiens_hsa049770.28945284
97Leishmaniasis_Homo sapiens_hsa051400.27461558
98RNA transport_Homo sapiens_hsa030130.26912167
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24236924
100GABAergic synapse_Homo sapiens_hsa047270.23049034

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