ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proline biosynthetic process (GO:0006561)	6.67699806
2	ribosomal small subunit assembly (GO:0000028)	6.00321708
3	positive regulation of response to tumor cell (GO:0002836)	5.78688208
4	positive regulation of immune response to tumor cell (GO:0002839)	5.78688208
5	regulation of immune response to tumor cell (GO:0002837)	5.78688208
6	regulation of response to tumor cell (GO:0002834)	5.78688208
7	chaperone-mediated protein transport (GO:0072321)	5.35976396
8	ribosomal small subunit biogenesis (GO:0042274)	4.94492289
9	GTP biosynthetic process (GO:0006183)	4.81010751
10	positive regulation by host of viral transcription (GO:0043923)	4.72032318
11	positive regulation of muscle cell apoptotic process (GO:0010661)	4.48764555
12	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.38733612
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.38256664
14	ATP synthesis coupled proton transport (GO:0015986)	4.38256664
15	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.31271434
16	proline metabolic process (GO:0006560)	4.30645701
17	viral transcription (GO:0019083)	4.23413563
18	UTP biosynthetic process (GO:0006228)	4.11023195
19	translational termination (GO:0006415)	4.08692030
20	neuronal action potential propagation (GO:0019227)	4.02744264
21	rRNA modification (GO:0000154)	4.01554971
22	ribosomal large subunit biogenesis (GO:0042273)	3.99939822
23	negative regulation by host of viral transcription (GO:0043922)	3.99598822
24	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.97878941
25	maturation of SSU-rRNA (GO:0030490)	3.94544091
26	response to xenobiotic stimulus (GO:0009410)	3.93536365
27	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.90823374
28	negative regulation of T cell differentiation in thymus (GO:0033085)	3.87600520
29	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.86833133
30	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.84982466
31	rRNA methylation (GO:0031167)	3.75005461
32	proteasome assembly (GO:0043248)	3.74640575
33	translational elongation (GO:0006414)	3.74344678
34	UTP metabolic process (GO:0046051)	3.67819457
35	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	3.66359033
36	DNA deamination (GO:0045006)	3.65966048
37	CTP biosynthetic process (GO:0006241)	3.62298952
38	CTP metabolic process (GO:0046036)	3.62298952
39	negative regulation of astrocyte differentiation (GO:0048712)	3.61979404
40	ribonucleoprotein complex biogenesis (GO:0022613)	3.61809936
41	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.55110653
42	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.54114804
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.51898430
44	water-soluble vitamin biosynthetic process (GO:0042364)	3.45568357
45	cotranslational protein targeting to membrane (GO:0006613)	3.44749512
46	guanosine-containing compound biosynthetic process (GO:1901070)	3.44295465
47	cellular component biogenesis (GO:0044085)	3.42182393
48	protein targeting to ER (GO:0045047)	3.40042678
49	spliceosomal complex assembly (GO:0000245)	3.36658018
50	protein deneddylation (GO:0000338)	3.36314547
51	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.35815573
52	deoxyribose phosphate biosynthetic process (GO:0046385)	3.35815573
53	protein localization to endoplasmic reticulum (GO:0070972)	3.24849716
54	intracellular protein transmembrane import (GO:0044743)	3.24377046
55	positive regulation of translational initiation (GO:0045948)	3.23618897
56	cullin deneddylation (GO:0010388)	3.22257759
57	protein neddylation (GO:0045116)	3.22113043
58	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.21980116
59	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.21980116
60	NADH dehydrogenase complex assembly (GO:0010257)	3.21980116
61	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.20618410
62	rRNA processing (GO:0006364)	3.20469209
63	ncRNA 3-end processing (GO:0043628)	3.20189505
64	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.18347484
65	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.16390368
66	viral life cycle (GO:0019058)	3.15245485
67	protein-cofactor linkage (GO:0018065)	3.11321744
68	rRNA metabolic process (GO:0016072)	3.10477999
69	protein complex biogenesis (GO:0070271)	3.09981955
70	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.09888833
71	response to nitrosative stress (GO:0051409)	3.08911165
72	regulation of smooth muscle cell apoptotic process (GO:0034391)	3.08293022
73	ribosome biogenesis (GO:0042254)	3.06760105
74	pseudouridine synthesis (GO:0001522)	3.03893150
75	modulation by host of viral transcription (GO:0043921)	3.03838994
76	modulation by host of symbiont transcription (GO:0052472)	3.03838994
77	translation (GO:0006412)	2.98811126
78	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.98428236
79	translational initiation (GO:0006413)	2.94272243
80	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.91390820
81	base-excision repair, AP site formation (GO:0006285)	2.90938656
82	mitochondrial respiratory chain complex assembly (GO:0033108)	2.89966696
83	regulation of interleukin-17 production (GO:0032660)	2.89565818
84	cellular protein complex disassembly (GO:0043624)	2.89253856
85	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.86834455
86	negative regulation of interleukin-17 production (GO:0032700)	2.86245076
87	regulation of isotype switching to IgG isotypes (GO:0048302)	2.86181224
88	protein import into peroxisome matrix (GO:0016558)	2.85110142
89	regulation of immunoglobulin secretion (GO:0051023)	2.82222687
90	mitochondrial genome maintenance (GO:0000002)	2.76655389
91	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.75938703
92	protein targeting to mitochondrion (GO:0006626)	2.75877059
93	positive regulation of interleukin-17 production (GO:0032740)	2.75691494
94	aggressive behavior (GO:0002118)	2.74802519
95	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.74648818
96	nucleoside diphosphate phosphorylation (GO:0006165)	2.74102518
97	cellular response to interleukin-15 (GO:0071350)	2.73665515
98	nucleoside triphosphate biosynthetic process (GO:0009142)	2.72789913
99	establishment of protein localization to peroxisome (GO:0072663)	2.71264845
100	protein localization to peroxisome (GO:0072662)	2.71264845

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.29018608
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.21227115
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.15894735
4	VDR_22108803_ChIP-Seq_LS180_Human	3.82197759
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65098084
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.22317134
7	GATA1_22025678_ChIP-Seq_K562_Human	3.12660740
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.09806146
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.04988874
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.98540846
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.87044223
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86766551
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.58885281
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.46267272
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.45439052
16	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.34494784
17	MYC_18940864_ChIP-ChIP_HL60_Human	2.33537177
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.24133419
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.24117700
20	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.22787053
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.19164597
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18296600
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.16277422
24	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02878613
25	FUS_26573619_Chip-Seq_HEK293_Human	1.90301828
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.87599259
27	TTF2_22483619_ChIP-Seq_HELA_Human	1.87342316
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.87210124
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.78593247
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.76178239
31	XRN2_22483619_ChIP-Seq_HELA_Human	1.71437110
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71093510
33	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.66720607
34	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.64742061
35	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.60012820
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.58507022
37	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.52679167
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48596691
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.47361581
40	DCP1A_22483619_ChIP-Seq_HELA_Human	1.44480596
41	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.39049714
42	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.37007859
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34598541
44	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.30100922
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29909362
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28953204
47	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.28878604
48	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.28195159
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23275465
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23275465
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.21946798
52	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19668086
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.16495814
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15545744
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15545744
56	P300_19829295_ChIP-Seq_ESCs_Human	1.15537399
57	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.15165919
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.13318223
59	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.10953724
60	KDM5A_27292631_Chip-Seq_BREAST_Human	1.10470870
61	EWS_26573619_Chip-Seq_HEK293_Human	1.09047724
62	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.07451281
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05034188
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.04516966
65	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.02034944
66	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.01021437
67	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00806797
68	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00610369
69	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.99699505
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99288265
71	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99151718
72	NCOR_22424771_ChIP-Seq_293T_Human	0.98998150
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97968311
74	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97348984
75	CBP_20019798_ChIP-Seq_JUKART_Human	0.97194031
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97194031
77	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.96358262
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94949280
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91734177
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91081752
81	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.89642393
82	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.87847091
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87829016
84	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87618402
85	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87532240
86	PHF8_20622853_ChIP-Seq_HELA_Human	0.87365759
87	HOXB7_26014856_ChIP-Seq_BT474_Human	0.86963659
88	ETV1_20927104_ChIP-Seq_GIST48_Human	0.85356757
89	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85296396
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.84835761
91	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.84735966
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.84499077
93	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.84405365
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.83322718
95	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.83029966
96	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.82210314
97	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.81794868
98	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.81655926
99	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.80764863
100	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.80631255

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	4.53524658
2	MP0006292_abnormal_olfactory_placode	4.07592489
3	MP0002736_abnormal_nociception_after	3.74039033
4	MP0003315_abnormal_perineum_morphology	2.70245533
5	MP0001968_abnormal_touch/_nociception	2.68646908
6	MP0004147_increased_porphyrin_level	2.58945939
7	MP0004142_abnormal_muscle_tone	2.53205008
8	MP0008058_abnormal_DNA_repair	2.50010951
9	MP0004885_abnormal_endolymph	2.49649048
10	MP0005646_abnormal_pituitary_gland	2.40383193
11	MP0002160_abnormal_reproductive_system	2.34702664
12	MP0001188_hyperpigmentation	2.26458264
13	MP0003806_abnormal_nucleotide_metabolis	2.24370771
14	MP0002876_abnormal_thyroid_physiology	2.14435114
15	MP0002837_dystrophic_cardiac_calcinosis	1.84720386
16	MP0009379_abnormal_foot_pigmentation	1.62689305
17	MP0005389_reproductive_system_phenotype	1.56861978
18	MP0000631_abnormal_neuroendocrine_gland	1.54760916
19	MP0002822_catalepsy	1.54350004
20	MP0005084_abnormal_gallbladder_morpholo	1.53876753
21	MP0008872_abnormal_physiological_respon	1.51854587
22	MP0008877_abnormal_DNA_methylation	1.44047295
23	MP0002735_abnormal_chemical_nociception	1.34123911
24	MP0001835_abnormal_antigen_presentation	1.33721714
25	MP0000750_abnormal_muscle_regeneration	1.32357217
26	MP0000566_synostosis	1.28738476
27	MP0002272_abnormal_nervous_system	1.27571305
28	MP0005645_abnormal_hypothalamus_physiol	1.24569527
29	MP0003879_abnormal_hair_cell	1.22412251
30	MP0004036_abnormal_muscle_relaxation	1.20332011
31	MP0001529_abnormal_vocalization	1.20113987
32	MP0001873_stomach_inflammation	1.20087279
33	MP0006276_abnormal_autonomic_nervous	1.19162379
34	MP0003718_maternal_effect	1.18632326
35	MP0002067_abnormal_sensory_capabilities	1.17922538
36	MP0000465_gastrointestinal_hemorrhage	1.17695583
37	MP0005671_abnormal_response_to	1.15635580
38	MP0002148_abnormal_hypersensitivity_rea	1.15174699
39	MP0003787_abnormal_imprinting	1.14928143
40	MP0005410_abnormal_fertilization	1.14114134
41	MP0003186_abnormal_redox_activity	1.13399195
42	MP0009745_abnormal_behavioral_response	1.12843843
43	MP0000049_abnormal_middle_ear	1.11833078
44	MP0002163_abnormal_gland_morphology	1.10639865
45	MP0004742_abnormal_vestibular_system	1.10574488
46	MP0004957_abnormal_blastocyst_morpholog	1.09828019
47	MP0000678_abnormal_parathyroid_gland	1.09277619
48	MP0002138_abnormal_hepatobiliary_system	1.09252125
49	MP0001501_abnormal_sleep_pattern	1.04522021
50	MP0003693_abnormal_embryo_hatching	1.04493783
51	MP0000681_abnormal_thyroid_gland	1.04311049
52	MP0001293_anophthalmia	1.02777486
53	MP0008775_abnormal_heart_ventricle	1.00354156
54	MP0002938_white_spotting	1.00248019
55	MP0002184_abnormal_innervation	0.97817762
56	MP0006072_abnormal_retinal_apoptosis	0.96416391
57	MP0002733_abnormal_thermal_nociception	0.96154377
58	MP0000685_abnormal_immune_system	0.96017726
59	MP0004924_abnormal_behavior	0.95995513
60	MP0005386_behavior/neurological_phenoty	0.95995513
61	MP0001970_abnormal_pain_threshold	0.95605332
62	MP0001853_heart_inflammation	0.95317017
63	MP0002102_abnormal_ear_morphology	0.92940016
64	MP0003786_premature_aging	0.92650510
65	MP0001440_abnormal_grooming_behavior	0.92351879
66	MP0003938_abnormal_ear_development	0.92262384
67	MP0002572_abnormal_emotion/affect_behav	0.90909528
68	MP0009765_abnormal_xenobiotic_induced	0.90766529
69	MP0002210_abnormal_sex_determination	0.90436769
70	MP0001905_abnormal_dopamine_level	0.88869488
71	MP0005083_abnormal_biliary_tract	0.88000469
72	MP0005423_abnormal_somatic_nervous	0.87437823
73	MP0002095_abnormal_skin_pigmentation	0.86634959
74	MP0009250_abnormal_appendicular_skeleto	0.86517530
75	MP0003890_abnormal_embryonic-extraembry	0.85047544
76	MP0000749_muscle_degeneration	0.85022022
77	MP0003698_abnormal_male_reproductive	0.84707213
78	MP0003077_abnormal_cell_cycle	0.83141938
79	MP0002277_abnormal_respiratory_mucosa	0.83055162
80	MP0002557_abnormal_social/conspecific_i	0.82762277
81	MP0001919_abnormal_reproductive_system	0.81358527
82	MP0002106_abnormal_muscle_physiology	0.81282885
83	MP0001986_abnormal_taste_sensitivity	0.81055985
84	MP0003880_abnormal_central_pattern	0.80968607
85	MP0003763_abnormal_thymus_physiology	0.80367151
86	MP0000026_abnormal_inner_ear	0.79453505
87	MP0005551_abnormal_eye_electrophysiolog	0.79292011
88	MP0005085_abnormal_gallbladder_physiolo	0.76568129
89	MP0000427_abnormal_hair_cycle	0.75369588
90	MP0001145_abnormal_male_reproductive	0.74784513
91	MP0000569_abnormal_digit_pigmentation	0.74747277
92	MP0000537_abnormal_urethra_morphology	0.73653868
93	MP0001764_abnormal_homeostasis	0.73651200
94	MP0003121_genomic_imprinting	0.71841945
95	MP0002751_abnormal_autonomic_nervous	0.71500751
96	MP0003942_abnormal_urinary_system	0.71150917
97	MP0002177_abnormal_outer_ear	0.70884087
98	MP0001963_abnormal_hearing_physiology	0.70785855
99	MP0003878_abnormal_ear_physiology	0.69684616
100	MP0005377_hearing/vestibular/ear_phenot	0.69684616

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.35358969
2	Constricted visual fields (HP:0001133)	4.34607583
3	3-Methylglutaconic aciduria (HP:0003535)	4.18495608
4	Abnormal rod and cone electroretinograms (HP:0008323)	3.88161341
5	Reticulocytopenia (HP:0001896)	3.56811945
6	Genetic anticipation (HP:0003743)	3.48050386
7	Myotonia (HP:0002486)	3.46043522
8	Optic disc pallor (HP:0000543)	3.45361160
9	Submucous cleft hard palate (HP:0000176)	3.43528424
10	Muscle hypertrophy of the lower extremities (HP:0008968)	3.18972812
11	Acute necrotizing encephalopathy (HP:0006965)	3.18425559
12	Oral leukoplakia (HP:0002745)	3.03083971
13	Congenital, generalized hypertrichosis (HP:0004540)	3.02782834
14	Mitochondrial inheritance (HP:0001427)	3.01149266
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.00563880
16	Abnormal number of erythroid precursors (HP:0012131)	2.99583068
17	Hepatocellular necrosis (HP:0001404)	2.98639947
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.93515075
19	Renal cortical cysts (HP:0000803)	2.91774583
20	Congenital stationary night blindness (HP:0007642)	2.81791763
21	Increased CSF lactate (HP:0002490)	2.81362414
22	Megalencephaly (HP:0001355)	2.80038864
23	Hepatic necrosis (HP:0002605)	2.77939508
24	Stomatitis (HP:0010280)	2.74271792
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.69342648
26	Acute encephalopathy (HP:0006846)	2.68357184
27	Macrocytic anemia (HP:0001972)	2.63477360
28	Attenuation of retinal blood vessels (HP:0007843)	2.60640681
29	Absent phalangeal crease (HP:0006109)	2.55754124
30	Progressive macrocephaly (HP:0004481)	2.52402414
31	Abnormality of the nasal septum (HP:0000419)	2.50881614
32	Progressive cerebellar ataxia (HP:0002073)	2.50281265
33	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.49434414
34	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.49434414
35	Colon cancer (HP:0003003)	2.49345556
36	Pallor (HP:0000980)	2.45459923
37	Brushfield spots (HP:0001088)	2.43930404
38	Severe combined immunodeficiency (HP:0004430)	2.42848360
39	Severe muscular hypotonia (HP:0006829)	2.40602757
40	Abnormal hemoglobin (HP:0011902)	2.35643702
41	Abnormality of macular pigmentation (HP:0008002)	2.34745435
42	Hyperglycinemia (HP:0002154)	2.28715210
43	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.28149633
44	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.22770691
45	Gaze-evoked nystagmus (HP:0000640)	2.21426328
46	Chronic bronchitis (HP:0004469)	2.18186799
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17580226
48	Retinal dysplasia (HP:0007973)	2.16720772
49	Thyroiditis (HP:0100646)	2.15957645
50	Molar tooth sign on MRI (HP:0002419)	2.13737092
51	Abnormality of midbrain morphology (HP:0002418)	2.13737092
52	Sparse lateral eyebrow (HP:0005338)	2.11054745
53	Hyperglycinuria (HP:0003108)	2.09422550
54	Lactic acidosis (HP:0003128)	2.07513252
55	Type 2 muscle fiber atrophy (HP:0003554)	2.05247561
56	Increased serum lactate (HP:0002151)	2.05150430
57	Abnormality of eosinophils (HP:0001879)	2.04353849
58	Methylmalonic acidemia (HP:0002912)	2.04205398
59	Abnormal finger flexion creases (HP:0006143)	2.02809621
60	IgG deficiency (HP:0004315)	2.02174037
61	Pendular nystagmus (HP:0012043)	2.01471393
62	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.00604624
63	Focal motor seizures (HP:0011153)	2.00134587
64	Abnormality of the renal cortex (HP:0011035)	1.98987963
65	Epiphyseal stippling (HP:0010655)	1.98778979
66	Broad-based gait (HP:0002136)	1.97904228
67	Nephronophthisis (HP:0000090)	1.97145634
68	Palpebral edema (HP:0100540)	1.93751382
69	Volvulus (HP:0002580)	1.90012812
70	Abnormal spermatogenesis (HP:0008669)	1.89951579
71	Muscle fiber atrophy (HP:0100295)	1.89379614
72	Urinary bladder sphincter dysfunction (HP:0002839)	1.88598865
73	Cerebral edema (HP:0002181)	1.85075518
74	Delayed CNS myelination (HP:0002188)	1.84509363
75	Female pseudohermaphroditism (HP:0010458)	1.82299101
76	Humeroradial synostosis (HP:0003041)	1.81830895
77	Synostosis involving the elbow (HP:0003938)	1.81830895
78	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.81799661
79	Increased hepatocellular lipid droplets (HP:0006565)	1.81065924
80	Short chin (HP:0000331)	1.80554172
81	Abnormality of the renal collecting system (HP:0004742)	1.77886303
82	Metaphyseal dysplasia (HP:0100255)	1.77167327
83	Acute lymphatic leukemia (HP:0006721)	1.75549914
84	Dysdiadochokinesis (HP:0002075)	1.75436772
85	Scanning speech (HP:0002168)	1.74491601
86	Abnormal albumin level (HP:0012116)	1.74096955
87	Hypoalbuminemia (HP:0003073)	1.74096955
88	Esophageal neoplasm (HP:0100751)	1.71322720
89	Neoplasm of head and neck (HP:0012288)	1.71322720
90	Pancytopenia (HP:0001876)	1.69675950
91	Abnormality of methionine metabolism (HP:0010901)	1.68991915
92	Muscle stiffness (HP:0003552)	1.67233052
93	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.67066429
94	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.67062238
95	Sclerocornea (HP:0000647)	1.66879751
96	Respiratory failure (HP:0002878)	1.66685143
97	Pancreatic cysts (HP:0001737)	1.66107664
98	Renal Fanconi syndrome (HP:0001994)	1.64195700
99	Febrile seizures (HP:0002373)	1.63449746
100	Chorioretinal atrophy (HP:0000533)	1.63161705

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRPM7	4.54555710
2	NUAK1	3.61579855
3	ZAK	3.48521491
4	VRK2	3.37707028
5	WNK3	3.20284680
6	NME2	2.98061255
7	TESK1	2.74278915
8	CDK19	2.49263571
9	KIT	2.24374785
10	VRK1	2.18964152
11	DYRK2	2.16514816
12	BCKDK	2.04707189
13	TSSK6	1.98921097
14	PDK2	1.90533690
15	ILK	1.88902762
16	MKNK1	1.60864877
17	TLK1	1.55556720
18	NTRK3	1.45835759
19	AKT3	1.44534913
20	PINK1	1.38651537
21	TAOK3	1.34114703
22	TIE1	1.28531704
23	HIPK2	1.25016640
24	PHKG1	1.23009196
25	PHKG2	1.23009196
26	NEK1	1.22261226
27	INSRR	1.20793747
28	WNK4	1.17004563
29	SCYL2	1.16694578
30	CAMKK2	1.14414656
31	GRK1	1.13813687
32	TEC	1.13752210
33	ADRBK2	1.10748044
34	ABL2	1.09582811
35	PLK3	1.05530662
36	CDC7	1.02879578
37	TXK	1.02860332
38	EPHA4	1.02350063
39	TAF1	0.97752631
40	BUB1	0.92232032
41	MATK	0.89213739
42	OXSR1	0.88447528
43	PRKCG	0.83317263
44	MST4	0.80481699
45	CASK	0.80379065
46	DAPK1	0.76330039
47	BCR	0.70915644
48	ITK	0.70795375
49	OBSCN	0.70774588
50	RPS6KA5	0.69393161
51	MKNK2	0.68792994
52	PIK3CA	0.68455560
53	MAPK13	0.67943671
54	EIF2AK2	0.67733730
55	MARK1	0.67575046
56	MAPKAPK5	0.67307831
57	IKBKB	0.63399474
58	EIF2AK3	0.61299625
59	PBK	0.58333745
60	CHEK2	0.54251099
61	NME1	0.52582615
62	DYRK3	0.52353539
63	EPHB2	0.51116151
64	FES	0.49757510
65	MAP2K6	0.47436463
66	PRKCQ	0.46268778
67	NLK	0.46020971
68	GRK5	0.44965991
69	ADRBK1	0.43603349
70	PRKCD	0.43041482
71	CSNK2A1	0.42970391
72	MAP4K2	0.42837407
73	GSK3A	0.42755829
74	LIMK1	0.42248199
75	CSNK2A2	0.41059537
76	ATR	0.40100648
77	CDK3	0.39112780
78	PRKD3	0.39044233
79	PLK4	0.38595926
80	TRIM28	0.38242875
81	CCNB1	0.38115994
82	RPS6KB2	0.37763110
83	RPS6KA4	0.35772537
84	LATS1	0.35092151
85	AURKA	0.34962847
86	MAP2K2	0.34770538
87	PRKACA	0.34247199
88	PIK3CG	0.33884711
89	ERBB4	0.33501578
90	FRK	0.33388914
91	CHEK1	0.33302101
92	CSNK1G1	0.32622926
93	STK38	0.32334048
94	FLT3	0.32154562
95	PRKG1	0.31569190
96	CAMK2G	0.31560398
97	CAMK2A	0.31280090
98	PAK1	0.30476427
99	ALK	0.29385142
100	IKBKE	0.29156554

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.62796878
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.34081250
3	RNA polymerase_Homo sapiens_hsa03020	3.05562957
4	Proteasome_Homo sapiens_hsa03050	3.03590096
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.03275514
6	Parkinsons disease_Homo sapiens_hsa05012	3.00843926
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.65609928
8	Allograft rejection_Homo sapiens_hsa05330	2.42136571
9	Basal transcription factors_Homo sapiens_hsa03022	2.12259878
10	Alzheimers disease_Homo sapiens_hsa05010	2.07991275
11	Huntingtons disease_Homo sapiens_hsa05016	2.03787581
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.95402063
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.92509712
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.86160046
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.83978448
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.77336369
17	Spliceosome_Homo sapiens_hsa03040	1.70314593
18	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.67528586
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.62594131
20	DNA replication_Homo sapiens_hsa03030	1.62574614
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.60385193
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.56977288
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.56216842
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.55215447
25	Asthma_Homo sapiens_hsa05310	1.52943603
26	Base excision repair_Homo sapiens_hsa03410	1.31816989
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.24756540
28	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.19159272
29	African trypanosomiasis_Homo sapiens_hsa05143	1.18875980
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.16687468
31	Protein export_Homo sapiens_hsa03060	1.15739651
32	RNA transport_Homo sapiens_hsa03013	1.15462729
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.14276368
34	Sulfur relay system_Homo sapiens_hsa04122	1.14231123
35	Peroxisome_Homo sapiens_hsa04146	1.13739485
36	Graft-versus-host disease_Homo sapiens_hsa05332	1.11692612
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.11277291
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09291777
39	RNA degradation_Homo sapiens_hsa03018	1.08033572
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.06615280
41	Nicotine addiction_Homo sapiens_hsa05033	1.04823098
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.04167393
43	Purine metabolism_Homo sapiens_hsa00230	1.04165651
44	Phototransduction_Homo sapiens_hsa04744	1.03946436
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00500739
46	Propanoate metabolism_Homo sapiens_hsa00640	1.00386228
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99286619
48	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97624455
49	Homologous recombination_Homo sapiens_hsa03440	0.96523429
50	Taste transduction_Homo sapiens_hsa04742	0.94000847
51	Folate biosynthesis_Homo sapiens_hsa00790	0.91816021
52	One carbon pool by folate_Homo sapiens_hsa00670	0.88135084
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85876085
54	Mismatch repair_Homo sapiens_hsa03430	0.85808856
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.84780679
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83942931
57	Olfactory transduction_Homo sapiens_hsa04740	0.82549470
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79737704
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76861887
60	Legionellosis_Homo sapiens_hsa05134	0.75581564
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.74990337
62	Glutathione metabolism_Homo sapiens_hsa00480	0.74973365
63	Non-homologous end-joining_Homo sapiens_hsa03450	0.74118278
64	Mineral absorption_Homo sapiens_hsa04978	0.73294326
65	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.69902156
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69720076
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68963360
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.68643365
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67540213
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.66493642
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64251564
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.63884277
73	Metabolic pathways_Homo sapiens_hsa01100	0.59138934
74	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.55471147
75	Salivary secretion_Homo sapiens_hsa04970	0.50791780
76	Butanoate metabolism_Homo sapiens_hsa00650	0.50708610
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48815268
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.46021492
79	Malaria_Homo sapiens_hsa05144	0.45391329
80	Tryptophan metabolism_Homo sapiens_hsa00380	0.43540812
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42930139
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40493735
83	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.39613697
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38975810
85	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.38906832
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.37446027
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.36822788
88	Measles_Homo sapiens_hsa05162	0.36269797
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34280753
90	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.33143837
91	Retinol metabolism_Homo sapiens_hsa00830	0.32910168
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.32370028
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.32043317
94	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.30904403
95	Serotonergic synapse_Homo sapiens_hsa04726	0.30741200
96	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.30587111
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30455639
98	Caffeine metabolism_Homo sapiens_hsa00232	0.26053820
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.22200371
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.20897027

RPS4XP10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »