ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.40934232
2	chaperone-mediated protein transport (GO:0072321)	7.07795004
3	viral transcription (GO:0019083)	6.87864030
4	ribosomal small subunit biogenesis (GO:0042274)	6.64793230
5	translational termination (GO:0006415)	6.57343858
6	DNA deamination (GO:0045006)	5.84000663
7	translational elongation (GO:0006414)	5.81146079
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.64517493
9	cotranslational protein targeting to membrane (GO:0006613)	5.54923218
10	ATP synthesis coupled proton transport (GO:0015986)	5.53429281
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.53429281
12	protein targeting to ER (GO:0045047)	5.51862905
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.26293687
14	maturation of SSU-rRNA (GO:0030490)	5.23875785
15	protein localization to endoplasmic reticulum (GO:0070972)	5.20379873
16	viral life cycle (GO:0019058)	4.99536438
17	cellular protein complex disassembly (GO:0043624)	4.98006739
18	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.84126552
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.75835389
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.65550961
21	ribosomal large subunit biogenesis (GO:0042273)	4.41652779
22	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.34422083
23	translational initiation (GO:0006413)	4.32321915
24	cytidine deamination (GO:0009972)	4.30731305
25	cytidine metabolic process (GO:0046087)	4.30731305
26	cytidine catabolic process (GO:0006216)	4.30731305
27	protein complex disassembly (GO:0043241)	4.05186196
28	translation (GO:0006412)	3.90517730
29	GTP biosynthetic process (GO:0006183)	3.89093566
30	protein neddylation (GO:0045116)	3.83726599
31	macromolecular complex disassembly (GO:0032984)	3.78641281
32	protein targeting to membrane (GO:0006612)	3.74896325
33	behavioral response to nicotine (GO:0035095)	3.69569039
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.69405383
35	neurofilament cytoskeleton organization (GO:0060052)	3.63785184
36	protein-cofactor linkage (GO:0018065)	3.59614451
37	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.58396959
38	ribonucleoprotein complex biogenesis (GO:0022613)	3.53346218
39	respiratory electron transport chain (GO:0022904)	3.48350365
40	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47060064
41	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47060064
42	electron transport chain (GO:0022900)	3.45597387
43	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.42155748
44	cellular component biogenesis (GO:0044085)	3.41588933
45	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.35374317
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.35374317
47	NADH dehydrogenase complex assembly (GO:0010257)	3.35374317
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.33948272
49	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.31278872
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.31097360
51	UTP biosynthetic process (GO:0006228)	3.30916726
52	UTP metabolic process (GO:0046051)	3.27738564
53	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.27355452
54	protein complex biogenesis (GO:0070271)	3.25644445
55	mRNA catabolic process (GO:0006402)	3.20394499
56	intracellular protein transmembrane import (GO:0044743)	3.19662974
57	negative regulation of T cell differentiation in thymus (GO:0033085)	3.18921943
58	ATP biosynthetic process (GO:0006754)	3.12782768
59	negative regulation of telomere maintenance (GO:0032205)	3.10160472
60	positive regulation of fatty acid transport (GO:2000193)	3.00333446
61	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.99773855
62	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91883413
63	RNA catabolic process (GO:0006401)	2.87749195
64	positive regulation of defense response to virus by host (GO:0002230)	2.83872492
65	protein targeting to mitochondrion (GO:0006626)	2.82792939
66	rRNA processing (GO:0006364)	2.82507908
67	positive regulation of prostaglandin secretion (GO:0032308)	2.82439395
68	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.81497174
69	rRNA metabolic process (GO:0016072)	2.81179615
70	guanosine-containing compound biosynthetic process (GO:1901070)	2.79683941
71	rRNA catabolic process (GO:0016075)	2.78492196
72	positive regulation of T cell apoptotic process (GO:0070234)	2.78408573
73	positive regulation of icosanoid secretion (GO:0032305)	2.76444657
74	kynurenine metabolic process (GO:0070189)	2.76234832
75	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.74884964
76	ncRNA 3-end processing (GO:0043628)	2.74723488
77	protein polyglutamylation (GO:0018095)	2.72958074
78	pseudouridine synthesis (GO:0001522)	2.70313469
79	interferon-gamma production (GO:0032609)	2.66657923
80	hydrogen ion transmembrane transport (GO:1902600)	2.66427234
81	mast cell activation (GO:0045576)	2.65474695
82	mast cell activation involved in immune response (GO:0002279)	2.64775716
83	mast cell degranulation (GO:0043303)	2.64775716
84	glyoxylate metabolic process (GO:0046487)	2.63290504
85	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.60762981
86	establishment of protein localization to mitochondrion (GO:0072655)	2.60418496
87	water-soluble vitamin biosynthetic process (GO:0042364)	2.59134963
88	protein targeting (GO:0006605)	2.55397589
89	regulation of cilium movement (GO:0003352)	2.55223891
90	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.53396595
91	establishment of protein localization to membrane (GO:0090150)	2.52190519
92	CTP biosynthetic process (GO:0006241)	2.49723643
93	CTP metabolic process (GO:0046036)	2.49723643
94	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.47767413
95	proton transport (GO:0015992)	2.46423564
96	cellular response to interleukin-15 (GO:0071350)	2.46166578
97	regulation of isotype switching to IgG isotypes (GO:0048302)	2.45808413
98	parturition (GO:0007567)	2.44857553
99	inner mitochondrial membrane organization (GO:0007007)	2.44315843
100	nucleoside triphosphate biosynthetic process (GO:0009142)	2.43044494

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.94130095
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.49712945
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.25312846
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.18983748
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.10171064
6	VDR_22108803_ChIP-Seq_LS180_Human	3.07444984
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03709681
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.85862222
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.84114321
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.81553647
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.73865493
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.61288363
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.43725692
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.30843182
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.30067962
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.22568227
17	IRF1_19129219_ChIP-ChIP_H3396_Human	2.16584028
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.98547006
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.98101889
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.97267814
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93517762
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.88513995
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.85933737
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.76627714
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.74716253
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.73582340
27	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.64645753
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.63870347
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.63393252
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.59436758
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.57049725
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.56842344
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.56371306
34	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.49401878
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.48293519
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43252193
37	NANOG_20526341_ChIP-Seq_ESCs_Human	1.43179171
38	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.42208119
39	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.41662737
40	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.41516082
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.36598607
42	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.34540453
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.31363603
44	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.30290215
45	NCOR_22424771_ChIP-Seq_293T_Human	1.30176317
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.29868763
47	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.25283964
48	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.24999561
49	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.24317945
50	ERA_21632823_ChIP-Seq_H3396_Human	1.24246405
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.23101502
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.22754318
53	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.20574318
54	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.15340552
55	AR_20517297_ChIP-Seq_VCAP_Human	1.12072329
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10874202
57	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.10595687
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10157122
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10157122
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10093689
61	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09836026
62	FUS_26573619_Chip-Seq_HEK293_Human	1.09820129
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08100927
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07818303
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.04546296
66	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.04329519
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03701376
68	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.03135766
69	GABP_19822575_ChIP-Seq_HepG2_Human	1.02705878
70	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.01453314
71	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00924609
72	CTCF_20526341_ChIP-Seq_ESCs_Human	1.00811417
73	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.00562551
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.99690861
75	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99429842
76	MYC_19829295_ChIP-Seq_ESCs_Human	0.99306702
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98864441
78	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.97987906
79	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97879270
80	CIITA_25753668_ChIP-Seq_RAJI_Human	0.97305763
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96608421
82	BCL6_27268052_Chip-Seq_Bcells_Human	0.95558842
83	E2F1_20622854_ChIP-Seq_HELA_Human	0.95409261
84	GATA3_26560356_Chip-Seq_TH2_Human	0.95359679
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95318816
86	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.94524776
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93643905
88	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93581154
89	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.93478077
90	EWS_26573619_Chip-Seq_HEK293_Human	0.92876187
91	SA1_27219007_Chip-Seq_Bcells_Human	0.91923277
92	RBPJ_21746931_ChIP-Seq_IB4_Human	0.89777148
93	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.89684683
94	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.89682443
95	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.89198300
96	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.87908108
97	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.87028354
98	DCP1A_22483619_ChIP-Seq_HELA_Human	0.86918197
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.86699330
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.86049654

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.55640609
2	MP0005671_abnormal_response_to	3.47838051
3	MP0006292_abnormal_olfactory_placode	3.25537575
4	MP0002163_abnormal_gland_morphology	2.68014025
5	MP0002638_abnormal_pupillary_reflex	2.46981264
6	MP0004885_abnormal_endolymph	2.32534263
7	MP0002876_abnormal_thyroid_physiology	2.30679343
8	MP0008995_early_reproductive_senescence	2.25277480
9	MP0003646_muscle_fatigue	2.20496880
10	MP0005646_abnormal_pituitary_gland	1.94797921
11	MP0004145_abnormal_muscle_electrophysio	1.92054020
12	MP0002653_abnormal_ependyma_morphology	1.91653797
13	MP0006072_abnormal_retinal_apoptosis	1.89373579
14	MP0009333_abnormal_splenocyte_physiolog	1.84299837
15	MP0002160_abnormal_reproductive_system	1.84200027
16	MP0008875_abnormal_xenobiotic_pharmacok	1.79462600
17	MP0002102_abnormal_ear_morphology	1.79225421
18	MP0002837_dystrophic_cardiac_calcinosis	1.79150525
19	MP0005377_hearing/vestibular/ear_phenot	1.77908698
20	MP0003878_abnormal_ear_physiology	1.77908698
21	MP0001835_abnormal_antigen_presentation	1.73578193
22	MP0005084_abnormal_gallbladder_morpholo	1.72915563
23	MP0004142_abnormal_muscle_tone	1.71212932
24	MP0005389_reproductive_system_phenotype	1.69014057
25	MP0008872_abnormal_physiological_respon	1.65517404
26	MP0001986_abnormal_taste_sensitivity	1.58747529
27	MP0004147_increased_porphyrin_level	1.58137105
28	MP0002138_abnormal_hepatobiliary_system	1.57331036
29	MP0005551_abnormal_eye_electrophysiolog	1.52281959
30	MP0003011_delayed_dark_adaptation	1.50236856
31	MP0005379_endocrine/exocrine_gland_phen	1.48980090
32	MP0003763_abnormal_thymus_physiology	1.47006911
33	MP0002234_abnormal_pharynx_morphology	1.43699411
34	MP0005645_abnormal_hypothalamus_physiol	1.42806272
35	MP0009785_altered_susceptibility_to	1.39999642
36	MP0001188_hyperpigmentation	1.39982325
37	MP0003786_premature_aging	1.39033420
38	MP0001873_stomach_inflammation	1.38418471
39	MP0001905_abnormal_dopamine_level	1.37512926
40	MP0008877_abnormal_DNA_methylation	1.36323123
41	MP0001919_abnormal_reproductive_system	1.34551254
42	MP0002736_abnormal_nociception_after	1.29615207
43	MP0002148_abnormal_hypersensitivity_rea	1.29332182
44	MP0003787_abnormal_imprinting	1.29275087
45	MP0004742_abnormal_vestibular_system	1.28817566
46	MP0001348_abnormal_lacrimal_gland	1.27116868
47	MP0005000_abnormal_immune_tolerance	1.25991230
48	MP0001968_abnormal_touch/_nociception	1.25018850
49	MP0001800_abnormal_humoral_immune	1.24538227
50	MP0001485_abnormal_pinna_reflex	1.19901273
51	MP0006276_abnormal_autonomic_nervous	1.16541186
52	MP0008789_abnormal_olfactory_epithelium	1.16512410
53	MP0005253_abnormal_eye_physiology	1.15424150
54	MP0000372_irregular_coat_pigmentation	1.14809786
55	MP0000049_abnormal_middle_ear	1.10109393
56	MP0002723_abnormal_immune_serum	1.09273624
57	MP0003186_abnormal_redox_activity	1.08564991
58	MP0004043_abnormal_pH_regulation	1.03504416
59	MP0009764_decreased_sensitivity_to	1.03346132
60	MP0009745_abnormal_behavioral_response	1.02671077
61	MP0005410_abnormal_fertilization	1.02122428
62	MP0001790_abnormal_immune_system	1.01674101
63	MP0005387_immune_system_phenotype	1.01674101
64	MP0002272_abnormal_nervous_system	1.01163901
65	MP0001293_anophthalmia	1.00847545
66	MP0003195_calcinosis	1.00124178
67	MP0003866_abnormal_defecation	0.98396613
68	MP0001501_abnormal_sleep_pattern	0.97572507
69	MP0002420_abnormal_adaptive_immunity	0.97496568
70	MP0006036_abnormal_mitochondrial_physio	0.96639556
71	MP0001819_abnormal_immune_cell	0.94784967
72	MP0005025_abnormal_response_to	0.92378884
73	MP0000685_abnormal_immune_system	0.90769163
74	MP0000631_abnormal_neuroendocrine_gland	0.89345775
75	MP0005174_abnormal_tail_pigmentation	0.84319464
76	MP0002928_abnormal_bile_duct	0.83667889
77	MP0005195_abnormal_posterior_eye	0.83487411
78	MP0002398_abnormal_bone_marrow	0.82722328
79	MP0001970_abnormal_pain_threshold	0.82489767
80	MP0008775_abnormal_heart_ventricle	0.82153671
81	MP0002210_abnormal_sex_determination	0.82072287
82	MP0003436_decreased_susceptibility_to	0.81609156
83	MP0002277_abnormal_respiratory_mucosa	0.81587226
84	MP0000678_abnormal_parathyroid_gland	0.81453745
85	MP0001119_abnormal_female_reproductive	0.81421574
86	MP0002938_white_spotting	0.80869555
87	MP0001881_abnormal_mammary_gland	0.79162105
88	MP0002452_abnormal_antigen_presenting	0.79066310
89	MP0001984_abnormal_olfaction	0.78950120
90	MP0002822_catalepsy	0.78607804
91	MP0003123_paternal_imprinting	0.78232345
92	MP0005394_taste/olfaction_phenotype	0.77050554
93	MP0005499_abnormal_olfactory_system	0.77050554
94	MP0000716_abnormal_immune_system	0.76811972
95	MP0002733_abnormal_thermal_nociception	0.75845211
96	MP0001440_abnormal_grooming_behavior	0.73979212
97	MP0002405_respiratory_system_inflammati	0.73230984
98	MP0003880_abnormal_central_pattern	0.72919560
99	MP0001845_abnormal_inflammatory_respons	0.72361707
100	MP0002095_abnormal_skin_pigmentation	0.71620374

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.65053312
2	3-Methylglutaconic aciduria (HP:0003535)	3.89536502
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.74123509
4	Aplastic anemia (HP:0001915)	3.70864757
5	Acute necrotizing encephalopathy (HP:0006965)	3.66005198
6	Congenital stationary night blindness (HP:0007642)	3.52533668
7	Abnormality of cells of the erythroid lineage (HP:0012130)	3.49916371
8	Mitochondrial inheritance (HP:0001427)	3.39092500
9	Molar tooth sign on MRI (HP:0002419)	3.22310806
10	Abnormality of midbrain morphology (HP:0002418)	3.22310806
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.17791305
12	Increased CSF lactate (HP:0002490)	3.12885066
13	Acute encephalopathy (HP:0006846)	3.10579951
14	Absent thumb (HP:0009777)	3.07026877
15	Macrocytic anemia (HP:0001972)	3.04377919
16	Progressive macrocephaly (HP:0004481)	3.03358480
17	Abnormality of the renal collecting system (HP:0004742)	2.99673746
18	Pancreatic fibrosis (HP:0100732)	2.88932815
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.87999161
20	Increased hepatocellular lipid droplets (HP:0006565)	2.85008174
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.82429464
22	Oral leukoplakia (HP:0002745)	2.80035745
23	Pallor (HP:0000980)	2.76974568
24	Absent/shortened dynein arms (HP:0200106)	2.74902114
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.74902114
26	Pancreatic cysts (HP:0001737)	2.71555664
27	Abnormal number of erythroid precursors (HP:0012131)	2.66726522
28	Duplicated collecting system (HP:0000081)	2.65986935
29	Renal cortical cysts (HP:0000803)	2.64439670
30	Cerebral edema (HP:0002181)	2.63623005
31	Abnormality of B cell number (HP:0010975)	2.63459102
32	Renal Fanconi syndrome (HP:0001994)	2.60931716
33	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.60410268
34	Hepatocellular necrosis (HP:0001404)	2.59374110
35	Chromsome breakage (HP:0040012)	2.56742391
36	Abnormality of the renal cortex (HP:0011035)	2.56527479
37	Elevated erythrocyte sedimentation rate (HP:0003565)	2.55780002
38	Increased IgM level (HP:0003496)	2.52348384
39	Lipid accumulation in hepatocytes (HP:0006561)	2.50492855
40	Hyperglycinemia (HP:0002154)	2.48373343
41	IgG deficiency (HP:0004315)	2.48113423
42	Stomatitis (HP:0010280)	2.47285171
43	Pancytopenia (HP:0001876)	2.47248358
44	Hepatic necrosis (HP:0002605)	2.44605391
45	True hermaphroditism (HP:0010459)	2.38482564
46	Pendular nystagmus (HP:0012043)	2.38436420
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.38023628
48	Optic disc pallor (HP:0000543)	2.36257132
49	Abnormality of DNA repair (HP:0003254)	2.34914435
50	Increased serum lactate (HP:0002151)	2.33319991
51	Abnormality of eosinophils (HP:0001879)	2.29000667
52	Increased intramyocellular lipid droplets (HP:0012240)	2.28462624
53	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.27657986
54	Abolished electroretinogram (ERG) (HP:0000550)	2.26495114
55	Abnormality of alanine metabolism (HP:0010916)	2.26457167
56	Hyperalaninemia (HP:0003348)	2.26457167
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.26457167
58	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.25204514
59	Stomach cancer (HP:0012126)	2.24341991
60	Nephronophthisis (HP:0000090)	2.18075439
61	Lactic acidosis (HP:0003128)	2.15990527
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15577847
63	Abnormal respiratory epithelium morphology (HP:0012253)	2.15577847
64	Decreased central vision (HP:0007663)	2.15270682
65	Abnormality of T cell number (HP:0011839)	2.11752182
66	Medial flaring of the eyebrow (HP:0010747)	2.10402425
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.06537288
68	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.06537288
69	Colon cancer (HP:0003003)	2.06478173
70	Stenosis of the external auditory canal (HP:0000402)	2.05768663
71	Microretrognathia (HP:0000308)	2.05355402
72	Congenital, generalized hypertrichosis (HP:0004540)	2.03704399
73	Abnormal ciliary motility (HP:0012262)	2.03170215
74	Meckel diverticulum (HP:0002245)	2.03024843
75	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.01696747
76	Attenuation of retinal blood vessels (HP:0007843)	1.99898985
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.98836573
78	Abnormality of T cells (HP:0002843)	1.98767871
79	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.97816792
80	Lethargy (HP:0001254)	1.97413774
81	Abnormality of the ileum (HP:0001549)	1.96932395
82	Eosinophilia (HP:0001880)	1.95393262
83	Autoimmune hemolytic anemia (HP:0001890)	1.94571257
84	Abnormality of the renal medulla (HP:0100957)	1.94491984
85	Asplenia (HP:0001746)	1.93672543
86	Type II lissencephaly (HP:0007260)	1.93452768
87	Hypoproteinemia (HP:0003075)	1.93262591
88	Constricted visual fields (HP:0001133)	1.92672045
89	Methylmalonic acidemia (HP:0002912)	1.88683665
90	Horseshoe kidney (HP:0000085)	1.87583083
91	Partial duplication of the phalanx of hand (HP:0009999)	1.85006026
92	Severe combined immunodeficiency (HP:0004430)	1.84293646
93	Increased muscle lipid content (HP:0009058)	1.83588492
94	Autoimmune thrombocytopenia (HP:0001973)	1.82369415
95	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.82193159
96	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.82087430
97	Abnormality of pyrimidine metabolism (HP:0004353)	1.81416521
98	Abnormality of the preputium (HP:0100587)	1.81158354
99	Exertional dyspnea (HP:0002875)	1.80816896
100	Abnormal respiratory motile cilium physiology (HP:0012261)	1.79893435

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	6.13642380
2	TXK	5.24896707
3	BCKDK	3.29268309
4	CDK19	2.91024137
5	MAP4K1	2.90347280
6	ZAK	2.88935916
7	ADRBK2	2.27671780
8	NUAK1	2.09221297
9	TLK1	2.03283337
10	NME2	1.86483256
11	PINK1	1.80957573
12	GRK1	1.78952669
13	CAMKK2	1.77364895
14	WNK4	1.71637156
15	KIT	1.70394162
16	FRK	1.61311282
17	ITK	1.57489562
18	PIK3CA	1.47909893
19	TESK2	1.41905487
20	PDK2	1.34183317
21	PASK	1.32887236
22	VRK2	1.27092246
23	DYRK2	1.26676519
24	TEC	1.26143150
25	TIE1	1.24157157
26	FES	1.19057994
27	STK16	1.18425034
28	IKBKB	1.15343034
29	PRKCQ	1.12700621
30	KDR	1.08619490
31	CAMK1	1.02451643
32	MAP2K7	1.01640375
33	OXSR1	0.99546503
34	CAMKK1	0.96137275
35	VRK1	0.95831393
36	IKBKE	0.94208024
37	LCK	0.93368079
38	BTK	0.92025083
39	GRK6	0.89987158
40	BMPR1B	0.87299896
41	SYK	0.87096896
42	INSRR	0.85433154
43	RPS6KA5	0.83200226
44	JAK3	0.79879655
45	CSNK1G1	0.74325513
46	MATK	0.68823268
47	STK39	0.68804729
48	MST4	0.68068196
49	MAP4K2	0.67446799
50	WNK3	0.67350506
51	MAP2K2	0.64735570
52	OBSCN	0.62365040
53	NEK1	0.60849476
54	PHKG1	0.57406390
55	PHKG2	0.57406390
56	GRK7	0.56976599
57	TRPM7	0.56599473
58	PIM2	0.55458200
59	AURKA	0.54086751
60	MAPK13	0.54021398
61	NLK	0.53693616
62	BUB1	0.53576813
63	PRKCG	0.53483015
64	PIM1	0.53462404
65	LYN	0.53091946
66	TBK1	0.51699681
67	ADRBK1	0.51161656
68	ATR	0.50507815
69	PRKCD	0.49659922
70	MAP3K14	0.48421999
71	NME1	0.48234116
72	IGF1R	0.46955655
73	PRKCA	0.46888035
74	GRK5	0.46815372
75	MAP2K6	0.46788027
76	MAP3K11	0.46153969
77	TNK2	0.45718270
78	LIMK1	0.45289550
79	CSNK2A1	0.43793839
80	PRKACA	0.43727802
81	CSNK2A2	0.42050606
82	PKN1	0.39990053
83	RPS6KA6	0.39462271
84	ABL2	0.37913705
85	DAPK3	0.37906841
86	FLT3	0.37899583
87	PIK3CG	0.37762284
88	CDK3	0.37004503
89	MUSK	0.36179549
90	CSNK1G3	0.35313649
91	RPS6KA4	0.35296221
92	ILK	0.33712806
93	DAPK2	0.31519443
94	ZAP70	0.30588725
95	MAPKAPK5	0.30488721
96	CSNK1G2	0.30330771
97	CSNK1A1	0.29358368
98	EPHA4	0.29265751
99	AKT2	0.29156882
100	BRSK2	0.28328156

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.87878884
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.67168246
3	Parkinsons disease_Homo sapiens_hsa05012	3.01181799
4	Allograft rejection_Homo sapiens_hsa05330	2.77691580
5	Proteasome_Homo sapiens_hsa03050	2.69866479
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.59423743
7	Asthma_Homo sapiens_hsa05310	2.59056405
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.39211592
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.25107701
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.17357281
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.10810447
12	Alzheimers disease_Homo sapiens_hsa05010	2.05328739
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.94305991
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.91530383
15	RNA polymerase_Homo sapiens_hsa03020	1.89663807
16	Huntingtons disease_Homo sapiens_hsa05016	1.88853025
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.84503439
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73398762
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.64265797
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.61561349
21	RNA degradation_Homo sapiens_hsa03018	1.52611635
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52348496
23	Protein export_Homo sapiens_hsa03060	1.49727129
24	Phototransduction_Homo sapiens_hsa04744	1.44229970
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.31765439
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29244215
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.28599456
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.26472001
29	Antigen processing and presentation_Homo sapiens_hsa04612	1.26155527
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25155345
31	One carbon pool by folate_Homo sapiens_hsa00670	1.22838499
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.20247403
33	Homologous recombination_Homo sapiens_hsa03440	1.14150517
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12624298
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.11611144
36	Rheumatoid arthritis_Homo sapiens_hsa05323	1.10261234
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06729131
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.04394859
39	Sulfur metabolism_Homo sapiens_hsa00920	1.04151369
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.03322980
41	Caffeine metabolism_Homo sapiens_hsa00232	1.02301216
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97274828
43	Peroxisome_Homo sapiens_hsa04146	0.94010967
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.92401055
45	Basal transcription factors_Homo sapiens_hsa03022	0.91208159
46	Mismatch repair_Homo sapiens_hsa03430	0.87011702
47	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.86698955
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84989616
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83997539
50	Purine metabolism_Homo sapiens_hsa00230	0.83156126
51	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.82333389
52	Olfactory transduction_Homo sapiens_hsa04740	0.78194670
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.71587585
54	Propanoate metabolism_Homo sapiens_hsa00640	0.69981150
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68121321
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66859393
57	Retinol metabolism_Homo sapiens_hsa00830	0.66836020
58	DNA replication_Homo sapiens_hsa03030	0.64363858
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63928383
60	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62038818
61	Sulfur relay system_Homo sapiens_hsa04122	0.61989254
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61616597
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61150495
64	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.59030234
65	Regulation of autophagy_Homo sapiens_hsa04140	0.58029576
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.57854152
67	Butanoate metabolism_Homo sapiens_hsa00650	0.57073162
68	Metabolic pathways_Homo sapiens_hsa01100	0.56277912
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55248432
70	Viral myocarditis_Homo sapiens_hsa05416	0.54296865
71	Spliceosome_Homo sapiens_hsa03040	0.54142974
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.52367200
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.51686130
74	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.50836709
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50739290
76	Morphine addiction_Homo sapiens_hsa05032	0.50616805
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49313218
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.48725163
79	Nicotine addiction_Homo sapiens_hsa05033	0.48256388
80	RNA transport_Homo sapiens_hsa03013	0.47547073
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44868150
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44718430
83	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.43973749
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43507541
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41237891
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40577222
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.39232088
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.39230075
89	Base excision repair_Homo sapiens_hsa03410	0.37511159
90	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.37410077
91	Taste transduction_Homo sapiens_hsa04742	0.35924326
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35490042
93	Serotonergic synapse_Homo sapiens_hsa04726	0.33531278
94	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31355301
95	Salivary secretion_Homo sapiens_hsa04970	0.29423747
96	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.29268485
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28923661
98	Malaria_Homo sapiens_hsa05144	0.27286651
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.23532209
100	Measles_Homo sapiens_hsa05162	0.21183824

RPS4XP11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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