ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	5.89854856
2	ribosomal small subunit assembly (GO:0000028)	5.83676197
3	translational termination (GO:0006415)	5.71929034
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.69161342
5	ATP synthesis coupled proton transport (GO:0015986)	5.69161342
6	maturation of SSU-rRNA (GO:0030490)	5.61331799
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.25052783
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.08529017
9	DNA deamination (GO:0045006)	5.07701253
10	translational elongation (GO:0006414)	5.04045590
11	ribosomal small subunit biogenesis (GO:0042274)	5.00678215
12	cotranslational protein targeting to membrane (GO:0006613)	4.99781759
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.98161871
14	protein targeting to ER (GO:0045047)	4.97089206
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.72602373
16	protein localization to endoplasmic reticulum (GO:0070972)	4.71783857
17	ribosomal large subunit biogenesis (GO:0042273)	4.46521973
18	viral life cycle (GO:0019058)	4.28803650
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.23585545
20	chaperone-mediated protein transport (GO:0072321)	4.22646170
21	cellular protein complex disassembly (GO:0043624)	4.21617972
22	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.10839077
23	behavioral response to nicotine (GO:0035095)	4.07068616
24	electron transport chain (GO:0022900)	4.02409662
25	respiratory electron transport chain (GO:0022904)	3.99925254
26	translational initiation (GO:0006413)	3.99093768
27	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.87986242
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.87779462
29	protein complex biogenesis (GO:0070271)	3.81799513
30	protein neddylation (GO:0045116)	3.78182659
31	piRNA metabolic process (GO:0034587)	3.76552437
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.73185978
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.73185978
34	NADH dehydrogenase complex assembly (GO:0010257)	3.73185978
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.67687169
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.67687169
37	translation (GO:0006412)	3.66846868
38	protein complex disassembly (GO:0043241)	3.48579783
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42859389
40	cytidine deamination (GO:0009972)	3.36697472
41	cytidine metabolic process (GO:0046087)	3.36697472
42	cytidine catabolic process (GO:0006216)	3.36697472
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.34933379
44	macromolecular complex disassembly (GO:0032984)	3.30782689
45	GTP biosynthetic process (GO:0006183)	3.28533268
46	cellular component biogenesis (GO:0044085)	3.26561740
47	protein-cofactor linkage (GO:0018065)	3.24667954
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.20702665
49	protein targeting to membrane (GO:0006612)	3.19330193
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.18014697
51	ribonucleoprotein complex biogenesis (GO:0022613)	3.17998962
52	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.17810385
53	ATP biosynthetic process (GO:0006754)	3.14424212
54	hydrogen ion transmembrane transport (GO:1902600)	3.09113970
55	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.07995825
56	positive regulation of prostaglandin secretion (GO:0032308)	3.07014265
57	proton transport (GO:0015992)	3.01586713
58	rRNA modification (GO:0000154)	3.00111073
59	hydrogen transport (GO:0006818)	2.99419655
60	L-fucose metabolic process (GO:0042354)	2.95242052
61	L-fucose catabolic process (GO:0042355)	2.95242052
62	fucose catabolic process (GO:0019317)	2.95242052
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.95076046
64	termination of RNA polymerase III transcription (GO:0006386)	2.95076046
65	proteasome assembly (GO:0043248)	2.94507260
66	intracellular protein transmembrane import (GO:0044743)	2.93299745
67	mRNA catabolic process (GO:0006402)	2.89425188
68	respiratory chain complex IV assembly (GO:0008535)	2.81032562
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.77975697
70	rRNA metabolic process (GO:0016072)	2.76708019
71	peptidyl-histidine modification (GO:0018202)	2.76098838
72	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.74405799
73	rRNA processing (GO:0006364)	2.73675507
74	base-excision repair, AP site formation (GO:0006285)	2.71759064
75	DNA methylation involved in gamete generation (GO:0043046)	2.70741346
76	UTP metabolic process (GO:0046051)	2.69993685
77	UTP biosynthetic process (GO:0006228)	2.68919604
78	negative regulation of T cell differentiation in thymus (GO:0033085)	2.67768343
79	regulation of chronic inflammatory response (GO:0002676)	2.65744993
80	platelet dense granule organization (GO:0060155)	2.65148755
81	response to pheromone (GO:0019236)	2.64194839
82	RNA catabolic process (GO:0006401)	2.63810367
83	tRNA processing (GO:0008033)	2.62329294
84	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.61268240
85	positive regulation of fatty acid transport (GO:2000193)	2.57764018
86	cytochrome complex assembly (GO:0017004)	2.57263526
87	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.54944376
88	pseudouridine synthesis (GO:0001522)	2.54829033
89	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.53259426
90	rRNA catabolic process (GO:0016075)	2.48935993
91	preassembly of GPI anchor in ER membrane (GO:0016254)	2.46041052
92	rRNA methylation (GO:0031167)	2.45132407
93	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.44879262
94	protein K6-linked ubiquitination (GO:0085020)	2.44157250
95	adaptation of signaling pathway (GO:0023058)	2.40967462
96	CTP biosynthetic process (GO:0006241)	2.39115492
97	CTP metabolic process (GO:0046036)	2.39115492
98	negative regulation of heart rate (GO:0010459)	2.38799653
99	regulation of mitochondrial translation (GO:0070129)	2.36052790
100	nucleoside triphosphate biosynthetic process (GO:0009142)	2.35924884

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.24355688
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.20778841
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.06094300
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.22805208
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.07415416
6	VDR_22108803_ChIP-Seq_LS180_Human	3.02083457
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.93223236
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.88149019
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.81545844
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.68718905
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46396091
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.44571100
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.42992336
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.09298008
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.07136448
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.02183245
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96392118
18	MYC_18940864_ChIP-ChIP_HL60_Human	1.93805665
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.87837322
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77394133
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.71381280
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.69556206
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67602418
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66599295
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.65562178
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.62405592
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61809391
28	TTF2_22483619_ChIP-Seq_HELA_Human	1.59310384
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.56825810
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56639365
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.56615620
32	FUS_26573619_Chip-Seq_HEK293_Human	1.55560647
33	EWS_26573619_Chip-Seq_HEK293_Human	1.55130778
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.52676425
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.50827623
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50777278
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46654276
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40717751
39	TAF2_19829295_ChIP-Seq_ESCs_Human	1.37040918
40	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.36116530
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.33736165
42	NANOG_20526341_ChIP-Seq_ESCs_Human	1.33694714
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32698330
44	GATA3_26560356_Chip-Seq_TH2_Human	1.32498642
45	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.31886412
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.31242714
47	AR_20517297_ChIP-Seq_VCAP_Human	1.28185295
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27495621
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27495621
50	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.26726358
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24827140
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24200941
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23067041
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23067041
55	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21880278
56	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.21855580
57	ERA_21632823_ChIP-Seq_H3396_Human	1.21814861
58	NCOR_22424771_ChIP-Seq_293T_Human	1.20791789
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20705438
60	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.16293502
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15827032
62	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14052339
63	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.13015607
64	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.11491225
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10697310
66	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.10565835
67	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.09954308
68	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09677710
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08472130
70	GABP_19822575_ChIP-Seq_HepG2_Human	1.07396922
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.04720190
72	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04361761
73	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.03641398
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.02234523
75	P300_19829295_ChIP-Seq_ESCs_Human	1.02183479
76	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.01626706
77	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01585904
78	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.01160842
79	XRN2_22483619_ChIP-Seq_HELA_Human	1.00920908
80	ER_23166858_ChIP-Seq_MCF-7_Human	1.00761788
81	P53_21459846_ChIP-Seq_SAOS-2_Human	1.00757820
82	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00700935
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99429593
84	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.98580223
85	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95460100
86	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.94453591
87	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93940311
88	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.91199987
89	RNF2_27304074_Chip-Seq_NSC_Mouse	0.90825260
90	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.90817418
91	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90741209
92	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.90529408
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.89987016
94	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.89309598
95	CIITA_25753668_ChIP-Seq_RAJI_Human	0.89149445
96	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88907892
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.88907892
98	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.88309504
99	STAT1_20625510_ChIP-Seq_HELA_Human	0.87918644
100	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.87750125

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.26829145
2	MP0005671_abnormal_response_to	3.07413982
3	MP0001835_abnormal_antigen_presentation	2.81417109
4	MP0008877_abnormal_DNA_methylation	2.73108475
5	MP0006072_abnormal_retinal_apoptosis	2.65482083
6	MP0002138_abnormal_hepatobiliary_system	2.43149414
7	MP0006292_abnormal_olfactory_placode	2.40359381
8	MP0005084_abnormal_gallbladder_morpholo	2.10256980
9	MP0004142_abnormal_muscle_tone	2.02923430
10	MP0008872_abnormal_physiological_respon	1.97638457
11	MP0002102_abnormal_ear_morphology	1.97248564
12	MP0003806_abnormal_nucleotide_metabolis	1.94212925
13	MP0003283_abnormal_digestive_organ	1.92421914
14	MP0001986_abnormal_taste_sensitivity	1.84467782
15	MP0005551_abnormal_eye_electrophysiolog	1.79588819
16	MP0005377_hearing/vestibular/ear_phenot	1.76595326
17	MP0003878_abnormal_ear_physiology	1.76595326
18	MP0008875_abnormal_xenobiotic_pharmacok	1.73105261
19	MP0004885_abnormal_endolymph	1.68074573
20	MP0002148_abnormal_hypersensitivity_rea	1.67555109
21	MP0003011_delayed_dark_adaptation	1.64842022
22	MP0006276_abnormal_autonomic_nervous	1.63739940
23	MP0004145_abnormal_muscle_electrophysio	1.62869101
24	MP0005379_endocrine/exocrine_gland_phen	1.60095508
25	MP0002163_abnormal_gland_morphology	1.59686473
26	MP0001968_abnormal_touch/_nociception	1.57984796
27	MP0005389_reproductive_system_phenotype	1.56111792
28	MP0003252_abnormal_bile_duct	1.53656504
29	MP0003195_calcinosis	1.52931886
30	MP0000685_abnormal_immune_system	1.50636805
31	MP0005645_abnormal_hypothalamus_physiol	1.49560217
32	MP0005253_abnormal_eye_physiology	1.45812999
33	MP0002876_abnormal_thyroid_physiology	1.39123544
34	MP0002160_abnormal_reproductive_system	1.38593477
35	MP0001919_abnormal_reproductive_system	1.37978008
36	MP0001905_abnormal_dopamine_level	1.37666640
37	MP0002272_abnormal_nervous_system	1.35733864
38	MP0009745_abnormal_behavioral_response	1.33638576
39	MP0005387_immune_system_phenotype	1.33499158
40	MP0001790_abnormal_immune_system	1.33499158
41	MP0001800_abnormal_humoral_immune	1.30258574
42	MP0003880_abnormal_central_pattern	1.30174379
43	MP0001348_abnormal_lacrimal_gland	1.28869004
44	MP0010386_abnormal_urinary_bladder	1.26359410
45	MP0006036_abnormal_mitochondrial_physio	1.25406061
46	MP0003186_abnormal_redox_activity	1.25134197
47	MP0003646_muscle_fatigue	1.24699132
48	MP0004043_abnormal_pH_regulation	1.24172523
49	MP0003866_abnormal_defecation	1.22505943
50	MP0002736_abnormal_nociception_after	1.20021281
51	MP0001984_abnormal_olfaction	1.19424434
52	MP0000631_abnormal_neuroendocrine_gland	1.19269185
53	MP0002837_dystrophic_cardiac_calcinosis	1.19040324
54	MP0004147_increased_porphyrin_level	1.19009050
55	MP0009333_abnormal_splenocyte_physiolog	1.16726575
56	MP0003693_abnormal_embryo_hatching	1.14232038
57	MP0001485_abnormal_pinna_reflex	1.13413173
58	MP0003786_premature_aging	1.12220357
59	MP0001501_abnormal_sleep_pattern	1.11478977
60	MP0005000_abnormal_immune_tolerance	1.11191758
61	MP0005075_abnormal_melanosome_morpholog	1.10666495
62	MP0009785_altered_susceptibility_to	1.09889185
63	MP0001873_stomach_inflammation	1.09662458
64	MP0002723_abnormal_immune_serum	1.05884612
65	MP0004133_heterotaxia	1.04487479
66	MP0002234_abnormal_pharynx_morphology	1.03789283
67	MP0001970_abnormal_pain_threshold	1.03501050
68	MP0005646_abnormal_pituitary_gland	1.03229713
69	MP0002277_abnormal_respiratory_mucosa	1.00728873
70	MP0003787_abnormal_imprinting	0.99745087
71	MP0002733_abnormal_thermal_nociception	0.99245526
72	MP0002653_abnormal_ependyma_morphology	0.97910617
73	MP0002420_abnormal_adaptive_immunity	0.97838255
74	MP0001440_abnormal_grooming_behavior	0.97076937
75	MP0001819_abnormal_immune_cell	0.97015463
76	MP0006035_abnormal_mitochondrial_morpho	0.96324851
77	MP0000372_irregular_coat_pigmentation	0.95842817
78	MP0001765_abnormal_ion_homeostasis	0.94143172
79	MP0002557_abnormal_social/conspecific_i	0.93820279
80	MP0002095_abnormal_skin_pigmentation	0.93516135
81	MP0009764_decreased_sensitivity_to	0.93478980
82	MP0008058_abnormal_DNA_repair	0.92953450
83	MP0001764_abnormal_homeostasis	0.91722423
84	MP0004742_abnormal_vestibular_system	0.90905599
85	MP0002638_abnormal_pupillary_reflex	0.90462757
86	MP0002452_abnormal_antigen_presenting	0.89922206
87	MP0002735_abnormal_chemical_nociception	0.89576355
88	MP0000049_abnormal_middle_ear	0.87595850
89	MP0005085_abnormal_gallbladder_physiolo	0.84355513
90	MP0001502_abnormal_circadian_rhythm	0.83599027
91	MP0009046_muscle_twitch	0.82642461
92	MP0002572_abnormal_emotion/affect_behav	0.82164324
93	MP0002938_white_spotting	0.81693933
94	MP0001881_abnormal_mammary_gland	0.81685509
95	MP0005636_abnormal_mineral_homeostasis	0.80693394
96	MP0003638_abnormal_response/metabolism_	0.78535774
97	MP0005332_abnormal_amino_acid	0.76822979
98	MP0002928_abnormal_bile_duct	0.76768256
99	MP0000230_abnormal_systemic_arterial	0.76301874
100	MP0009765_abnormal_xenobiotic_induced	0.75918829

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.71029843
2	Acute necrotizing encephalopathy (HP:0006965)	4.36470629
3	Mitochondrial inheritance (HP:0001427)	4.03947646
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.90110298
5	Increased CSF lactate (HP:0002490)	3.68291130
6	Progressive macrocephaly (HP:0004481)	3.66323563
7	Hepatocellular necrosis (HP:0001404)	3.65495194
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.61810686
9	Acute encephalopathy (HP:0006846)	3.54552215
10	Reticulocytopenia (HP:0001896)	3.50422280
11	Hepatic necrosis (HP:0002605)	3.37398708
12	Stomatitis (HP:0010280)	3.30746047
13	Aplastic anemia (HP:0001915)	3.25550692
14	Congenital stationary night blindness (HP:0007642)	3.22695223
15	Molar tooth sign on MRI (HP:0002419)	3.21187577
16	Abnormality of midbrain morphology (HP:0002418)	3.21187577
17	Abolished electroretinogram (ERG) (HP:0000550)	3.20856538
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.19615885
19	Abnormal number of erythroid precursors (HP:0012131)	3.12389654
20	Elevated erythrocyte sedimentation rate (HP:0003565)	3.05976716
21	Pancreatic cysts (HP:0001737)	2.99460096
22	Macrocytic anemia (HP:0001972)	2.92204599
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.90622679
24	Abnormality of alanine metabolism (HP:0010916)	2.90622679
25	Hyperalaninemia (HP:0003348)	2.90622679
26	Pancreatic fibrosis (HP:0100732)	2.90150025
27	IgG deficiency (HP:0004315)	2.90045121
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.87160061
29	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.87160061
30	Congenital, generalized hypertrichosis (HP:0004540)	2.86801185
31	Increased hepatocellular lipid droplets (HP:0006565)	2.85913158
32	Increased serum lactate (HP:0002151)	2.85490382
33	Cerebral edema (HP:0002181)	2.83327295
34	Abnormality of the renal cortex (HP:0011035)	2.75853049
35	Optic disc pallor (HP:0000543)	2.75039815
36	Lipid accumulation in hepatocytes (HP:0006561)	2.69649591
37	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.68146907
38	Methylmalonic acidemia (HP:0002912)	2.67279007
39	Lactic acidosis (HP:0003128)	2.60869182
40	Nephronophthisis (HP:0000090)	2.54630706
41	True hermaphroditism (HP:0010459)	2.49583838
42	Methylmalonic aciduria (HP:0012120)	2.46667784
43	Abnormal rod and cone electroretinograms (HP:0008323)	2.45606630
44	Pallor (HP:0000980)	2.43096840
45	Type II lissencephaly (HP:0007260)	2.38262201
46	Renal cortical cysts (HP:0000803)	2.31465590
47	Pendular nystagmus (HP:0012043)	2.27984389
48	Increased intramyocellular lipid droplets (HP:0012240)	2.27792170
49	Polydipsia (HP:0001959)	2.26921262
50	Abnormal drinking behavior (HP:0030082)	2.26921262
51	Renal Fanconi syndrome (HP:0001994)	2.25821072
52	Abnormality of the renal medulla (HP:0100957)	2.21219327
53	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.17922365
54	Attenuation of retinal blood vessels (HP:0007843)	2.16993968
55	Respiratory failure (HP:0002878)	2.16195341
56	Lethargy (HP:0001254)	2.13453208
57	Constricted visual fields (HP:0001133)	2.10676791
58	Type 2 muscle fiber atrophy (HP:0003554)	2.04203720
59	Pancytopenia (HP:0001876)	2.02733138
60	Sclerocornea (HP:0000647)	2.02518545
61	Hyperglycinemia (HP:0002154)	2.02483747
62	Hypomagnesemia (HP:0002917)	2.02111670
63	Hypoproteinemia (HP:0003075)	2.01229058
64	Exertional dyspnea (HP:0002875)	2.00639593
65	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.98661462
66	Concave nail (HP:0001598)	1.98310246
67	Polyuria (HP:0000103)	1.96266140
68	Generalized aminoaciduria (HP:0002909)	1.95446117
69	Abnormality of serum amino acid levels (HP:0003112)	1.95302067
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95229408
71	Abnormality of magnesium homeostasis (HP:0004921)	1.94797540
72	Leukodystrophy (HP:0002415)	1.94481476
73	Glycosuria (HP:0003076)	1.94239000
74	Abnormality of urine glucose concentration (HP:0011016)	1.94239000
75	Asplenia (HP:0001746)	1.93172611
76	Stenosis of the external auditory canal (HP:0000402)	1.90994290
77	Increased IgM level (HP:0003496)	1.90373330
78	Colon cancer (HP:0003003)	1.86441520
79	Decreased central vision (HP:0007663)	1.85682399
80	Absent thumb (HP:0009777)	1.84708276
81	Chronic hepatic failure (HP:0100626)	1.83961925
82	Abnormality of the labia minora (HP:0012880)	1.83606600
83	Increased muscle lipid content (HP:0009058)	1.82977471
84	Tubular atrophy (HP:0000092)	1.81989093
85	Abnormality of the prostate (HP:0008775)	1.81225780
86	Exercise intolerance (HP:0003546)	1.76585876
87	Absent/shortened dynein arms (HP:0200106)	1.74728774
88	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.74728774
89	Medial flaring of the eyebrow (HP:0010747)	1.71363221
90	Muscle fiber atrophy (HP:0100295)	1.71002387
91	Hyperphosphaturia (HP:0003109)	1.69447698
92	Aplasia/hypoplasia of the uterus (HP:0008684)	1.69358949
93	Cystic liver disease (HP:0006706)	1.66324066
94	Male pseudohermaphroditism (HP:0000037)	1.65942945
95	CNS demyelination (HP:0007305)	1.64134540
96	Keratoconus (HP:0000563)	1.63717865
97	Increased corneal curvature (HP:0100692)	1.63717865
98	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.63433415
99	Dicarboxylic aciduria (HP:0003215)	1.63433415
100	Hypoplasia of the ulna (HP:0003022)	1.62883561

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.16100219
2	TXK	3.09054807
3	TAOK3	3.06866640
4	PINK1	3.03808079
5	NUAK1	2.97612836
6	VRK2	2.91049380
7	ADRBK2	2.84415193
8	WNK4	2.81134775
9	MAP4K2	2.79613162
10	BCKDK	2.62542839
11	ZAK	2.50003863
12	CDK19	2.22009885
13	MAP4K1	1.93297137
14	GRK1	1.90989562
15	VRK1	1.89602641
16	STK16	1.61737801
17	FRK	1.59011288
18	MST4	1.56655476
19	FES	1.53391981
20	EIF2AK3	1.30606232
21	DYRK2	1.29208435
22	MAP3K12	1.27440081
23	KDR	1.24411356
24	CAMKK2	1.21348008
25	ITK	1.20606587
26	TEC	1.18221185
27	GRK6	1.17369595
28	OXSR1	1.11753146
29	IKBKB	1.07903047
30	STK39	1.07352899
31	KIT	1.02407024
32	MUSK	1.01618679
33	RPS6KA4	1.01591764
34	DAPK2	1.00358089
35	PASK	0.98602760
36	NME2	0.96773834
37	SCYL2	0.93066651
38	MAP2K7	0.92619276
39	PHKG2	0.90358755
40	PHKG1	0.90358755
41	BMPR1B	0.89875874
42	MAP3K14	0.88011839
43	RPS6KA5	0.87610950
44	PDK2	0.86837545
45	TIE1	0.85181075
46	PRKCQ	0.84330023
47	CSNK1G3	0.82942309
48	ADRBK1	0.82188991
49	NEK1	0.80952208
50	NME1	0.80893611
51	SYK	0.79438995
52	MAP3K11	0.79287094
53	BUB1	0.79175535
54	CSNK1G2	0.78689288
55	TAF1	0.77655816
56	BTK	0.77184773
57	GRK5	0.76962130
58	GRK7	0.74948319
59	WNK3	0.73146636
60	INSRR	0.72642718
61	AURKA	0.70168839
62	MAP2K2	0.69118622
63	CDK3	0.67852296
64	IKBKE	0.66036443
65	CSNK1A1L	0.65850663
66	TRIM28	0.64770341
67	TNK2	0.61898107
68	CAMKK1	0.59756763
69	LCK	0.56962691
70	MYLK	0.55872430
71	MAPK15	0.55487470
72	MAP3K4	0.54073919
73	CSF1R	0.53308368
74	DAPK3	0.52547512
75	LYN	0.52412927
76	EIF2AK2	0.52210105
77	PRKCH	0.50425492
78	PRKACA	0.48835879
79	CSNK1G1	0.47764673
80	PLK3	0.47255132
81	PLK1	0.45985331
82	LIMK1	0.45752913
83	WNK1	0.45591867
84	PRKCG	0.44858340
85	PRKCE	0.44513855
86	CAMK1	0.44139349
87	OBSCN	0.42876126
88	PIK3CG	0.42721282
89	CSNK2A1	0.42519840
90	MAPK13	0.42400308
91	PIM1	0.42215729
92	CSNK2A2	0.41637946
93	LRRK2	0.41208543
94	TGFBR1	0.38991832
95	MINK1	0.38326234
96	PRKCA	0.36691053
97	PLK4	0.36221022
98	DAPK1	0.34936187
99	CSNK1A1	0.34805762
100	ATR	0.34584200

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.78386105
2	Asthma_Homo sapiens_hsa05310	3.91719974
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.66691932
4	Allograft rejection_Homo sapiens_hsa05330	3.29001586
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.10602892
6	Parkinsons disease_Homo sapiens_hsa05012	2.98736413
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.97515902
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.71249501
9	Proteasome_Homo sapiens_hsa03050	2.64328041
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.47278633
11	RNA polymerase_Homo sapiens_hsa03020	2.26438522
12	Protein export_Homo sapiens_hsa03060	2.12267285
13	Alzheimers disease_Homo sapiens_hsa05010	2.06709506
14	Huntingtons disease_Homo sapiens_hsa05016	1.88478628
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.85851639
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.76162224
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71150965
18	Phototransduction_Homo sapiens_hsa04744	1.69951554
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.58538685
20	One carbon pool by folate_Homo sapiens_hsa00670	1.53774261
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50182953
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.46144882
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.34176617
24	RNA degradation_Homo sapiens_hsa03018	1.32702106
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.31061380
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29711570
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28649718
28	Propanoate metabolism_Homo sapiens_hsa00640	1.16241270
29	Homologous recombination_Homo sapiens_hsa03440	1.11992378
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11158176
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.06749075
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03955328
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01600475
34	Viral myocarditis_Homo sapiens_hsa05416	1.01460158
35	Basal transcription factors_Homo sapiens_hsa03022	1.01045379
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.00193969
37	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.98916722
38	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98673451
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.96962776
40	Nitrogen metabolism_Homo sapiens_hsa00910	0.94582363
41	Nucleotide excision repair_Homo sapiens_hsa03420	0.93967879
42	Folate biosynthesis_Homo sapiens_hsa00790	0.93577233
43	Peroxisome_Homo sapiens_hsa04146	0.92607698
44	Mismatch repair_Homo sapiens_hsa03430	0.88443615
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87910500
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85520378
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.85352400
48	Caffeine metabolism_Homo sapiens_hsa00232	0.84313040
49	Purine metabolism_Homo sapiens_hsa00230	0.82802477
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.80776112
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78166316
52	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.70174210
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69940301
54	Butanoate metabolism_Homo sapiens_hsa00650	0.68950330
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68463028
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67940755
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.66034947
58	Nicotine addiction_Homo sapiens_hsa05033	0.65174450
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64875296
60	Sulfur relay system_Homo sapiens_hsa04122	0.64856386
61	Regulation of autophagy_Homo sapiens_hsa04140	0.63528159
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63339768
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63303284
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.58259674
65	DNA replication_Homo sapiens_hsa03030	0.57860800
66	Retinol metabolism_Homo sapiens_hsa00830	0.56374879
67	Sulfur metabolism_Homo sapiens_hsa00920	0.56049027
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55654882
69	Metabolic pathways_Homo sapiens_hsa01100	0.55425347
70	Spliceosome_Homo sapiens_hsa03040	0.55115254
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55103980
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.54252190
73	RNA transport_Homo sapiens_hsa03013	0.54006131
74	Leishmaniasis_Homo sapiens_hsa05140	0.53555283
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52780455
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.51799737
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51034044
78	Olfactory transduction_Homo sapiens_hsa04740	0.50545428
79	Base excision repair_Homo sapiens_hsa03410	0.49677666
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49267419
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49259067
82	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.45734929
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43097643
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.41748064
85	Morphine addiction_Homo sapiens_hsa05032	0.41353455
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.40516743
87	Pyruvate metabolism_Homo sapiens_hsa00620	0.36703181
88	Salivary secretion_Homo sapiens_hsa04970	0.34657900
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.34093683
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32692579
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.32629500
92	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.32218210
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28799053
94	Fatty acid elongation_Homo sapiens_hsa00062	0.28638675
95	Taste transduction_Homo sapiens_hsa04742	0.27173905
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26456273
97	Serotonergic synapse_Homo sapiens_hsa04726	0.24804179
98	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.24775326
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24252606
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23347949

RPS4XP13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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