ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.58550347
2	ribosomal small subunit assembly (GO:0000028)	5.01400542
3	maturation of 5.8S rRNA (GO:0000460)	4.29700664
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.26831808
5	ribosomal large subunit biogenesis (GO:0042273)	4.25550149
6	piRNA metabolic process (GO:0034587)	3.82472235
7	rRNA modification (GO:0000154)	3.69512645
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.65219429
9	ATP synthesis coupled proton transport (GO:0015986)	3.64998960
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.64998960
11	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.62065313
12	chaperone-mediated protein transport (GO:0072321)	3.47365464
13	pseudouridine synthesis (GO:0001522)	3.44978918
14	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.38989342
15	termination of RNA polymerase III transcription (GO:0006386)	3.38989342
16	viral transcription (GO:0019083)	3.37368832
17	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.36674663
18	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.31528174
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.31168466
20	DNA replication checkpoint (GO:0000076)	3.30284908
21	ubiquinone biosynthetic process (GO:0006744)	3.28995578
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.28858849
23	translational termination (GO:0006415)	3.24760295
24	protein complex biogenesis (GO:0070271)	3.23647702
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.20733680
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.20733680
27	NADH dehydrogenase complex assembly (GO:0010257)	3.20733680
28	proline transport (GO:0015824)	3.20710745
29	protein deneddylation (GO:0000338)	3.17920266
30	chromatin remodeling at centromere (GO:0031055)	3.16764856
31	behavioral response to ethanol (GO:0048149)	3.10892390
32	ubiquinone metabolic process (GO:0006743)	3.07541412
33	translational elongation (GO:0006414)	3.07358447
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.07309165
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.07309165
36	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.06303761
37	cotranslational protein targeting to membrane (GO:0006613)	3.05489415
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.05377000
39	rRNA methylation (GO:0031167)	3.04987777
40	cullin deneddylation (GO:0010388)	3.03745304
41	behavioral response to nicotine (GO:0035095)	3.01388008
42	CENP-A containing nucleosome assembly (GO:0034080)	3.00499674
43	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.99967503
44	regulation of mitotic spindle checkpoint (GO:1903504)	2.99967503
45	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.99928349
46	maturation of SSU-rRNA (GO:0030490)	2.96860149
47	protein targeting to ER (GO:0045047)	2.94847343
48	GTP biosynthetic process (GO:0006183)	2.94699697
49	S-adenosylmethionine metabolic process (GO:0046500)	2.92509060
50	response to pheromone (GO:0019236)	2.92421831
51	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.92072347
52	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.85137790
53	rRNA catabolic process (GO:0016075)	2.84573432
54	protein localization to endoplasmic reticulum (GO:0070972)	2.83217031
55	rRNA processing (GO:0006364)	2.82684791
56	rRNA metabolic process (GO:0016072)	2.80235979
57	translation (GO:0006412)	2.79938325
58	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.79480739
59	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.78680996
60	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.76129080
61	regulation of cellular amino acid metabolic process (GO:0006521)	2.74614530
62	cytidine deamination (GO:0009972)	2.74489835
63	cytidine metabolic process (GO:0046087)	2.74489835
64	cytidine catabolic process (GO:0006216)	2.74489835
65	peptidyl-histidine modification (GO:0018202)	2.73808406
66	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.73576687
67	resolution of meiotic recombination intermediates (GO:0000712)	2.73169201
68	quinone biosynthetic process (GO:1901663)	2.72886332
69	positive regulation of defense response to virus by host (GO:0002230)	2.71980599
70	preassembly of GPI anchor in ER membrane (GO:0016254)	2.71343590
71	DNA methylation involved in gamete generation (GO:0043046)	2.71298746
72	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.71254878
73	cellular component biogenesis (GO:0044085)	2.70810930
74	mannosylation (GO:0097502)	2.70233563
75	translational initiation (GO:0006413)	2.69977414
76	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.68240594
77	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.68240594
78	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.68240594
79	indolalkylamine metabolic process (GO:0006586)	2.68037118
80	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.65815232
81	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.65815232
82	respiratory chain complex IV assembly (GO:0008535)	2.65728587
83	L-fucose catabolic process (GO:0042355)	2.65727190
84	fucose catabolic process (GO:0019317)	2.65727190
85	L-fucose metabolic process (GO:0042354)	2.65727190
86	ribonucleoprotein complex biogenesis (GO:0022613)	2.65195998
87	DNA demethylation (GO:0080111)	2.65122556
88	RNA destabilization (GO:0050779)	2.64559247
89	oxidative demethylation (GO:0070989)	2.61781314
90	regulation of immunoglobulin secretion (GO:0051023)	2.61606296
91	signal peptide processing (GO:0006465)	2.61177073
92	kynurenine metabolic process (GO:0070189)	2.60101778
93	proteasome assembly (GO:0043248)	2.58600640
94	positive regulation of prostaglandin secretion (GO:0032308)	2.58389187
95	tRNA processing (GO:0008033)	2.57744540
96	electron transport chain (GO:0022900)	2.55852176
97	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.54595459
98	isotype switching (GO:0045190)	2.54595459
99	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.54595459
100	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.54410098

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.13534461
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.12028746
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.63936678
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.51078566
5	VDR_22108803_ChIP-Seq_LS180_Human	3.10639489
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90927310
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.78174093
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.55945353
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.50554422
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.48485022
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.47741664
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.43915843
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.43370605
14	EWS_26573619_Chip-Seq_HEK293_Human	2.42341404
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.38429998
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34210897
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.29409831
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25595648
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.21440138
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.17593766
21	FUS_26573619_Chip-Seq_HEK293_Human	2.13388624
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04410689
23	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.02065854
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.92484596
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.88284445
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.83722292
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.77293675
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.76632950
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.74807838
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.74727662
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.74217988
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71804052
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.68567685
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.67482452
35	P300_19829295_ChIP-Seq_ESCs_Human	1.64989940
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60054332
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.58336508
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50167618
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.46956390
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.46255993
41	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.42221434
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36713933
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36509663
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30305548
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30226639
46	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28929238
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.28837509
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27179059
49	GBX2_23144817_ChIP-Seq_PC3_Human	1.26174304
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.26100203
51	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.25628878
52	E2F7_22180533_ChIP-Seq_HELA_Human	1.23770620
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.22943106
54	DCP1A_22483619_ChIP-Seq_HELA_Human	1.22914241
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22284981
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22284981
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20013474
58	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.19684684
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19161791
60	AR_20517297_ChIP-Seq_VCAP_Human	1.18135546
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17797417
62	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.17704326
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13157131
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10092304
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07721283
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07721283
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05280257
68	GATA3_26560356_Chip-Seq_TH2_Human	1.05243022
69	NCOR_22424771_ChIP-Seq_293T_Human	1.04378277
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03593872
71	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02374829
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01906659
73	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.00951895
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.00323552
75	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.00143823
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99890351
77	CIITA_25753668_ChIP-Seq_RAJI_Human	0.96468355
78	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.96221156
79	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.96213466
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96192101
81	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.95891482
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.95282985
83	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95247055
84	CBP_20019798_ChIP-Seq_JUKART_Human	0.95247055
85	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94920831
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.93940688
87	GATA3_26560356_Chip-Seq_TH1_Human	0.92921142
88	GABP_19822575_ChIP-Seq_HepG2_Human	0.92847160
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92726974
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.91367185
91	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.89988892
92	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.89549786
93	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.88875834
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.88496580
95	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.88263557
96	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.88172824
97	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.87704476
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.87668534
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.87003462
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.86968095

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.15203689
2	MP0008875_abnormal_xenobiotic_pharmacok	2.97708239
3	MP0002736_abnormal_nociception_after	2.83455881
4	MP0001986_abnormal_taste_sensitivity	2.52360208
5	MP0001968_abnormal_touch/_nociception	2.51446467
6	MP0006072_abnormal_retinal_apoptosis	2.29298154
7	MP0003136_yellow_coat_color	2.26035999
8	MP0002138_abnormal_hepatobiliary_system	2.22002840
9	MP0003195_calcinosis	2.12170109
10	MP0000372_irregular_coat_pigmentation	2.10781054
11	MP0008872_abnormal_physiological_respon	1.92660598
12	MP0008877_abnormal_DNA_methylation	1.90180612
13	MP0002277_abnormal_respiratory_mucosa	1.89027381
14	MP0003786_premature_aging	1.83298473
15	MP0001835_abnormal_antigen_presentation	1.82936885
16	MP0006292_abnormal_olfactory_placode	1.81523339
17	MP0008058_abnormal_DNA_repair	1.80652500
18	MP0009379_abnormal_foot_pigmentation	1.79741383
19	MP0002837_dystrophic_cardiac_calcinosis	1.73569361
20	MP0003718_maternal_effect	1.69852314
21	MP0003283_abnormal_digestive_organ	1.68674490
22	MP0003693_abnormal_embryo_hatching	1.66559366
23	MP0003880_abnormal_central_pattern	1.65617171
24	MP0005671_abnormal_response_to	1.63395648
25	MP0002876_abnormal_thyroid_physiology	1.62181822
26	MP0002160_abnormal_reproductive_system	1.62181026
27	MP0002653_abnormal_ependyma_morphology	1.60805924
28	MP0005551_abnormal_eye_electrophysiolog	1.59692319
29	MP0008995_early_reproductive_senescence	1.56332211
30	MP0004145_abnormal_muscle_electrophysio	1.52101355
31	MP0004142_abnormal_muscle_tone	1.48453120
32	MP0002163_abnormal_gland_morphology	1.46290718
33	MP0003646_muscle_fatigue	1.46228869
34	MP0005253_abnormal_eye_physiology	1.44128257
35	MP0005645_abnormal_hypothalamus_physiol	1.41777834
36	MP0001501_abnormal_sleep_pattern	1.40734828
37	MP0001293_anophthalmia	1.39889647
38	MP0005389_reproductive_system_phenotype	1.38289526
39	MP0000685_abnormal_immune_system	1.37306688
40	MP0001873_stomach_inflammation	1.36391495
41	MP0005646_abnormal_pituitary_gland	1.31300437
42	MP0001919_abnormal_reproductive_system	1.26438405
43	MP0002006_tumorigenesis	1.26288397
44	MP0002938_white_spotting	1.25872874
45	MP0001905_abnormal_dopamine_level	1.25362211
46	MP0002166_altered_tumor_susceptibility	1.24241758
47	MP0005084_abnormal_gallbladder_morpholo	1.20183154
48	MP0003806_abnormal_nucleotide_metabolis	1.19042049
49	MP0002272_abnormal_nervous_system	1.16878972
50	MP0004957_abnormal_blastocyst_morpholog	1.15756441
51	MP0002928_abnormal_bile_duct	1.15106128
52	MP0002282_abnormal_trachea_morphology	1.13646668
53	MP0009745_abnormal_behavioral_response	1.11853934
54	MP0005075_abnormal_melanosome_morpholog	1.10068952
55	MP0005379_endocrine/exocrine_gland_phen	1.09796394
56	MP0003937_abnormal_limbs/digits/tail_de	1.09562206
57	MP0003252_abnormal_bile_duct	1.06696479
58	MP0003011_delayed_dark_adaptation	1.06663513
59	MP0010094_abnormal_chromosome_stability	1.05052754
60	MP0006276_abnormal_autonomic_nervous	1.04976642
61	MP0004147_increased_porphyrin_level	1.04343186
62	MP0003186_abnormal_redox_activity	1.02253418
63	MP0000465_gastrointestinal_hemorrhage	1.01910088
64	MP0002095_abnormal_skin_pigmentation	0.99526720
65	MP0002735_abnormal_chemical_nociception	0.99096512
66	MP0005365_abnormal_bile_salt	0.98760987
67	MP0000631_abnormal_neuroendocrine_gland	0.95314301
68	MP0006036_abnormal_mitochondrial_physio	0.94682407
69	MP0002139_abnormal_hepatobiliary_system	0.92531346
70	MP0004043_abnormal_pH_regulation	0.90519344
71	MP0005410_abnormal_fertilization	0.89562731
72	MP0002210_abnormal_sex_determination	0.88436550
73	MP0002751_abnormal_autonomic_nervous	0.87743200
74	MP0002733_abnormal_thermal_nociception	0.86744499
75	MP0003890_abnormal_embryonic-extraembry	0.86301115
76	MP0001929_abnormal_gametogenesis	0.81998714
77	MP0005195_abnormal_posterior_eye	0.81929269
78	MP0000647_abnormal_sebaceous_gland	0.81719426
79	MP0001529_abnormal_vocalization	0.81580181
80	MP0000427_abnormal_hair_cycle	0.81318688
81	MP0002638_abnormal_pupillary_reflex	0.80922026
82	MP0002557_abnormal_social/conspecific_i	0.80202671
83	MP0008775_abnormal_heart_ventricle	0.80085018
84	MP0000653_abnormal_sex_gland	0.79314486
85	MP0005387_immune_system_phenotype	0.78141803
86	MP0001790_abnormal_immune_system	0.78141803
87	MP0009764_decreased_sensitivity_to	0.77265051
88	MP0001145_abnormal_male_reproductive	0.75192373
89	MP0003698_abnormal_male_reproductive	0.73606229
90	MP0008007_abnormal_cellular_replicative	0.73498963
91	MP0005367_renal/urinary_system_phenotyp	0.73047618
92	MP0000516_abnormal_urinary_system	0.73047618
93	MP0001800_abnormal_humoral_immune	0.72676756
94	MP0000538_abnormal_urinary_bladder	0.71534881
95	MP0001984_abnormal_olfaction	0.71109063
96	MP0009333_abnormal_splenocyte_physiolog	0.71047419
97	MP0001119_abnormal_female_reproductive	0.70878907
98	MP0005360_urolithiasis	0.69999489
99	MP0001286_abnormal_eye_development	0.68775770
100	MP0002693_abnormal_pancreas_physiology	0.68200164

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	3.93983554
2	Acute necrotizing encephalopathy (HP:0006965)	3.87633811
3	Pancreatic cysts (HP:0001737)	3.73607750
4	Pancreatic fibrosis (HP:0100732)	3.49554312
5	Progressive macrocephaly (HP:0004481)	3.40594510
6	Acute encephalopathy (HP:0006846)	3.35314292
7	Mitochondrial inheritance (HP:0001427)	3.29336054
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.24978581
9	Increased CSF lactate (HP:0002490)	3.18957194
10	True hermaphroditism (HP:0010459)	3.09666905
11	Stomatitis (HP:0010280)	3.08888887
12	Molar tooth sign on MRI (HP:0002419)	2.99617264
13	Abnormality of midbrain morphology (HP:0002418)	2.99617264
14	Congenital, generalized hypertrichosis (HP:0004540)	2.89153688
15	Increased hepatocellular lipid droplets (HP:0006565)	2.78534716
16	Cerebellar dysplasia (HP:0007033)	2.73996018
17	Colon cancer (HP:0003003)	2.72159275
18	Lipid accumulation in hepatocytes (HP:0006561)	2.67771729
19	IgG deficiency (HP:0004315)	2.65155414
20	Increased serum lactate (HP:0002151)	2.61748144
21	Hepatocellular necrosis (HP:0001404)	2.57602154
22	Chronic hepatic failure (HP:0100626)	2.56679550
23	Congenital stationary night blindness (HP:0007642)	2.52268292
24	Progressive inability to walk (HP:0002505)	2.51215594
25	Nephronophthisis (HP:0000090)	2.47456253
26	Optic disc pallor (HP:0000543)	2.47423817
27	Reticulocytopenia (HP:0001896)	2.44356975
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.44079069
29	Hepatic necrosis (HP:0002605)	2.43677051
30	Pendular nystagmus (HP:0012043)	2.42767014
31	Tubular atrophy (HP:0000092)	2.41770702
32	Absent thumb (HP:0009777)	2.41654803
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.41497202
34	Cerebral edema (HP:0002181)	2.40881388
35	Abolished electroretinogram (ERG) (HP:0000550)	2.33761022
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.33150639
37	Absent/shortened dynein arms (HP:0200106)	2.33150639
38	Renal Fanconi syndrome (HP:0001994)	2.29529865
39	Abnormal number of erythroid precursors (HP:0012131)	2.27455377
40	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.26677378
41	Abnormality of the renal cortex (HP:0011035)	2.25959289
42	Abnormality of the renal medulla (HP:0100957)	2.20331681
43	Retinal dysplasia (HP:0007973)	2.19148149
44	Asplenia (HP:0001746)	2.18632715
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.16283674
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.16108884
47	Abnormal biliary tract physiology (HP:0012439)	2.15878597
48	Bile duct proliferation (HP:0001408)	2.15878597
49	Abnormality of the labia minora (HP:0012880)	2.13524131
50	Attenuation of retinal blood vessels (HP:0007843)	2.13387810
51	Glycosuria (HP:0003076)	2.12411001
52	Abnormality of urine glucose concentration (HP:0011016)	2.12411001
53	Clubbing of toes (HP:0100760)	2.11692305
54	Pancytopenia (HP:0001876)	2.11452403
55	Constricted visual fields (HP:0001133)	2.09427142
56	Male pseudohermaphroditism (HP:0000037)	2.08415388
57	Meckel diverticulum (HP:0002245)	2.08017009
58	Cystic liver disease (HP:0006706)	2.06571031
59	Lactic acidosis (HP:0003128)	2.02522076
60	3-Methylglutaconic aciduria (HP:0003535)	1.98600101
61	Rib fusion (HP:0000902)	1.97695670
62	Hyperglycinuria (HP:0003108)	1.97246582
63	Supernumerary spleens (HP:0009799)	1.97209157
64	Abnormal respiratory epithelium morphology (HP:0012253)	1.97128434
65	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97128434
66	Lethargy (HP:0001254)	1.96627741
67	Abnormality of the ileum (HP:0001549)	1.96616034
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.95846838
69	Elevated erythrocyte sedimentation rate (HP:0003565)	1.95407147
70	Macrocytic anemia (HP:0001972)	1.94805886
71	Bilateral microphthalmos (HP:0007633)	1.91892239
72	Abnormality of the preputium (HP:0100587)	1.91818737
73	Gonadotropin excess (HP:0000837)	1.91295263
74	Increased IgM level (HP:0003496)	1.90973712
75	Abnormality of B cell number (HP:0010975)	1.88719209
76	Sclerocornea (HP:0000647)	1.88377695
77	Inability to walk (HP:0002540)	1.87162595
78	Exertional dyspnea (HP:0002875)	1.84008371
79	Methylmalonic aciduria (HP:0012120)	1.83456369
80	Polydipsia (HP:0001959)	1.82933350
81	Abnormal drinking behavior (HP:0030082)	1.82933350
82	Stomach cancer (HP:0012126)	1.81613021
83	Stenosis of the external auditory canal (HP:0000402)	1.80173947
84	Increased intramyocellular lipid droplets (HP:0012240)	1.79648453
85	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.78884107
86	Leukodystrophy (HP:0002415)	1.78498710
87	CNS hypomyelination (HP:0003429)	1.77239734
88	Gonadal dysgenesis (HP:0000133)	1.76778308
89	Optic nerve hypoplasia (HP:0000609)	1.76558290
90	Increased corneal curvature (HP:0100692)	1.75619870
91	Keratoconus (HP:0000563)	1.75619870
92	Abnormality of the pons (HP:0007361)	1.74786497
93	Septo-optic dysplasia (HP:0100842)	1.74716752
94	Renal cortical cysts (HP:0000803)	1.74628661
95	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.73979560
96	Respiratory failure (HP:0002878)	1.73979350
97	Triphalangeal thumb (HP:0001199)	1.73400963
98	Methylmalonic acidemia (HP:0002912)	1.72891705
99	Thyroiditis (HP:0100646)	1.72201529
100	Aplastic anemia (HP:0001915)	1.72142486

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.27963970
2	NUAK1	3.19654130
3	EIF2AK3	3.07509052
4	ADRBK2	2.45154046
5	TRIM28	2.33072651
6	BMPR1B	2.20449266
7	MST4	2.15055598
8	TSSK6	2.10548919
9	MAP4K2	2.04553964
10	ZAK	2.04077801
11	VRK2	2.01834052
12	NLK	1.98597764
13	TLK1	1.96986472
14	CDK19	1.94740565
15	TXK	1.85024674
16	STK16	1.72649388
17	EIF2AK1	1.70366462
18	CSNK1G1	1.67218743
19	CDC7	1.61522380
20	TAOK3	1.56868833
21	GRK1	1.54601707
22	VRK1	1.52680785
23	MAPK13	1.51861592
24	BUB1	1.51089550
25	INSRR	1.44203156
26	WNK3	1.36395926
27	EPHA4	1.35353373
28	PLK3	1.32006056
29	NME1	1.28727322
30	CAMKK2	1.27357867
31	NTRK3	1.26529703
32	ACVR1B	1.18776401
33	WNK4	1.16691294
34	PIK3CA	1.12632240
35	PLK4	1.12544910
36	DYRK2	1.11684734
37	MKNK2	1.07951033
38	PINK1	1.03256886
39	MAPKAPK3	1.01629597
40	IKBKB	0.96185941
41	PDK2	0.91638681
42	NEK1	0.88585546
43	TTK	0.87474538
44	TEC	0.87083878
45	TNIK	0.86537190
46	BCKDK	0.85589906
47	CSNK1G3	0.85368505
48	BRSK2	0.84604725
49	IKBKE	0.81191758
50	FGFR2	0.80128708
51	EIF2AK2	0.77935719
52	STK3	0.76369598
53	PLK2	0.76316223
54	PASK	0.75129520
55	PNCK	0.74681769
56	OXSR1	0.74587031
57	TGFBR1	0.73660232
58	TIE1	0.73451070
59	DYRK1A	0.71558364
60	CDK3	0.70646057
61	SIK3	0.70059908
62	CSNK1G2	0.69893400
63	NEK6	0.65413745
64	WEE1	0.64970205
65	SGK2	0.63594483
66	MKNK1	0.62157605
67	AURKB	0.61678547
68	DYRK3	0.58634638
69	ATR	0.56367660
70	CASK	0.54267956
71	PRKCQ	0.53845217
72	BCR	0.53613871
73	RPS6KA4	0.53454093
74	RPS6KA5	0.53357730
75	TAF1	0.52781064
76	MARK3	0.52450101
77	PLK1	0.52151909
78	CSNK1A1L	0.51961405
79	KIT	0.51534347
80	STK39	0.51424057
81	PRKCI	0.50662561
82	ADRBK1	0.50450234
83	PAK3	0.50242962
84	MAP3K12	0.46205919
85	PHKG2	0.43804984
86	PHKG1	0.43804984
87	PIM1	0.43695908
88	BRAF	0.43316331
89	PRKCG	0.43275535
90	MAPK7	0.42888695
91	MAP4K1	0.41491242
92	CCNB1	0.40767491
93	CAMK1	0.40283318
94	CHUK	0.35630566
95	STK38L	0.34549423
96	SGK494	0.33922727
97	SGK223	0.33922727
98	CSNK2A1	0.30202779
99	PRKACA	0.29895451
100	PRKCE	0.29709034

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.89265078
2	Ribosome_Homo sapiens_hsa03010	3.39399623
3	RNA polymerase_Homo sapiens_hsa03020	2.85468463
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.75795335
5	Protein export_Homo sapiens_hsa03060	2.47620618
6	Homologous recombination_Homo sapiens_hsa03440	2.41642835
7	Asthma_Homo sapiens_hsa05310	2.38997894
8	Parkinsons disease_Homo sapiens_hsa05012	2.32286499
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.09365642
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.00524971
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.84240627
12	Basal transcription factors_Homo sapiens_hsa03022	1.84221487
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.80122704
14	Phototransduction_Homo sapiens_hsa04744	1.78031810
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.77635648
16	Caffeine metabolism_Homo sapiens_hsa00232	1.75616586
17	RNA degradation_Homo sapiens_hsa03018	1.71712200
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.70060309
19	Allograft rejection_Homo sapiens_hsa05330	1.68914535
20	Huntingtons disease_Homo sapiens_hsa05016	1.65704295
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64437835
22	Mismatch repair_Homo sapiens_hsa03430	1.62800083
23	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.61500119
24	One carbon pool by folate_Homo sapiens_hsa00670	1.56439933
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53907185
26	Butanoate metabolism_Homo sapiens_hsa00650	1.52195588
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.50135349
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.39943448
29	Alzheimers disease_Homo sapiens_hsa05010	1.39654910
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.38087656
31	Propanoate metabolism_Homo sapiens_hsa00640	1.30479407
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.30198693
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29333488
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.27684452
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26870404
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.26708850
37	DNA replication_Homo sapiens_hsa03030	1.25455420
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.24948450
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.21921244
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18222501
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.17787045
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12993580
43	Purine metabolism_Homo sapiens_hsa00230	1.10766337
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.05675916
45	RNA transport_Homo sapiens_hsa03013	1.05357351
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00568177
47	Base excision repair_Homo sapiens_hsa03410	0.97976734
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.97170089
49	Steroid biosynthesis_Homo sapiens_hsa00100	0.97037253
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95822314
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.95321905
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94734440
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94538055
54	Peroxisome_Homo sapiens_hsa04146	0.93352590
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92829398
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.89991807
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.89643236
58	Sulfur metabolism_Homo sapiens_hsa00920	0.89002276
59	Spliceosome_Homo sapiens_hsa03040	0.85414640
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83931915
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83532457
62	Taste transduction_Homo sapiens_hsa04742	0.81837360
63	Olfactory transduction_Homo sapiens_hsa04740	0.77357090
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76737468
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75980751
66	Retinol metabolism_Homo sapiens_hsa00830	0.70129836
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.69846674
68	Metabolic pathways_Homo sapiens_hsa01100	0.66250903
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65278326
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64555809
71	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64004159
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61265146
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61259054
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61210556
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60877076
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60500147
77	Sulfur relay system_Homo sapiens_hsa04122	0.57716181
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.57497396
79	Nicotine addiction_Homo sapiens_hsa05033	0.55799144
80	Fatty acid elongation_Homo sapiens_hsa00062	0.54871577
81	Fatty acid degradation_Homo sapiens_hsa00071	0.54125826
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52346335
83	Regulation of autophagy_Homo sapiens_hsa04140	0.50759924
84	Glutathione metabolism_Homo sapiens_hsa00480	0.46624758
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.42890941
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42659022
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41297137
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39885167
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.37931480
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35807689
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.34444508
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.33593462
93	Folate biosynthesis_Homo sapiens_hsa00790	0.32200868
94	Insulin secretion_Homo sapiens_hsa04911	0.26298292
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.25275269
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.24897000
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.24751963
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.24723925
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.24152182
100	Amphetamine addiction_Homo sapiens_hsa05031	0.23072318

RPS4XP14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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