ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.80202231
2	kynurenine metabolic process (GO:0070189)	5.58198899
3	tryptophan catabolic process (GO:0006569)	5.12279387
4	indole-containing compound catabolic process (GO:0042436)	5.12279387
5	indolalkylamine catabolic process (GO:0046218)	5.12279387
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.03287234
7	tachykinin receptor signaling pathway (GO:0007217)	4.86526455
8	positive regulation of protein homodimerization activity (GO:0090073)	4.78303765
9	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.76384236
10	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.69145568
11	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.57591199
12	tryptophan metabolic process (GO:0006568)	4.28442901
13	protein complex biogenesis (GO:0070271)	4.22926712
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.99160761
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.93617689
16	NADH dehydrogenase complex assembly (GO:0010257)	3.93617689
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.93617689
18	cytochrome complex assembly (GO:0017004)	3.89279315
19	ATP synthesis coupled proton transport (GO:0015986)	3.84328237
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.84328237
21	rRNA catabolic process (GO:0016075)	3.78224786
22	meiotic chromosome segregation (GO:0045132)	3.69362468
23	behavioral response to nicotine (GO:0035095)	3.66906528
24	maturation of SSU-rRNA (GO:0030490)	3.64604552
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.60787543
26	metallo-sulfur cluster assembly (GO:0031163)	3.57083013
27	iron-sulfur cluster assembly (GO:0016226)	3.57083013
28	indolalkylamine metabolic process (GO:0006586)	3.52945906
29	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.43823326
30	cytidine metabolic process (GO:0046087)	3.41482041
31	cytidine catabolic process (GO:0006216)	3.41482041
32	cytidine deamination (GO:0009972)	3.41482041
33	protein neddylation (GO:0045116)	3.36803033
34	cellular ketone body metabolic process (GO:0046950)	3.35075872
35	respiratory chain complex IV assembly (GO:0008535)	3.34072492
36	regulation of hexokinase activity (GO:1903299)	3.33260040
37	regulation of glucokinase activity (GO:0033131)	3.33260040
38	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.29446171
39	regulation of uterine smooth muscle contraction (GO:0070472)	3.26867219
40	cellular biogenic amine catabolic process (GO:0042402)	3.26678097
41	amine catabolic process (GO:0009310)	3.26678097
42	water-soluble vitamin biosynthetic process (GO:0042364)	3.26233053
43	peptidyl-histidine modification (GO:0018202)	3.25512206
44	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.23173097
45	regulation of immunoglobulin secretion (GO:0051023)	3.21345633
46	synapsis (GO:0007129)	3.17351154
47	aromatic amino acid family catabolic process (GO:0009074)	3.10868107
48	proteasome assembly (GO:0043248)	3.00973717
49	regulation of mitochondrial translation (GO:0070129)	3.00830435
50	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.00024944
51	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.00024944
52	isotype switching (GO:0045190)	3.00024944
53	replication fork processing (GO:0031297)	2.96217940
54	electron transport chain (GO:0022900)	2.96135519
55	ketone body metabolic process (GO:1902224)	2.95215270
56	ribosomal small subunit assembly (GO:0000028)	2.92726883
57	maturation of 5.8S rRNA (GO:0000460)	2.89274082
58	respiratory electron transport chain (GO:0022904)	2.89217871
59	rRNA modification (GO:0000154)	2.88302895
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.87381976
61	chaperone-mediated protein transport (GO:0072321)	2.86694800
62	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.85390591
63	regulation of action potential (GO:0098900)	2.85084706
64	aldehyde catabolic process (GO:0046185)	2.84730069
65	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.83184408
66	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.83184408
67	regulation of cellular amino acid metabolic process (GO:0006521)	2.82480534
68	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.79466435
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76350413
70	positive regulation of defense response to virus by host (GO:0002230)	2.75331588
71	DNA double-strand break processing (GO:0000729)	2.73952048
72	spliceosomal complex assembly (GO:0000245)	2.73881173
73	hydrogen ion transmembrane transport (GO:1902600)	2.73532309
74	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.73281167
75	transcription from mitochondrial promoter (GO:0006390)	2.72686752
76	DNA strand renaturation (GO:0000733)	2.71476593
77	multicellular organism reproduction (GO:0032504)	2.68755058
78	response to pheromone (GO:0019236)	2.67702371
79	adenosine metabolic process (GO:0046085)	2.67327605
80	benzene-containing compound metabolic process (GO:0042537)	2.66394792
81	pseudouridine synthesis (GO:0001522)	2.66317807
82	inner mitochondrial membrane organization (GO:0007007)	2.64469408
83	regulation of chronic inflammatory response (GO:0002676)	2.63641472
84	piRNA metabolic process (GO:0034587)	2.63629443
85	negative regulation of thymocyte apoptotic process (GO:0070244)	2.63065057
86	regulation of thymocyte apoptotic process (GO:0070243)	2.62657366
87	GTP biosynthetic process (GO:0006183)	2.61249349
88	regulation of feeding behavior (GO:0060259)	2.61196886
89	activated T cell proliferation (GO:0050798)	2.60871129
90	mitochondrial RNA metabolic process (GO:0000959)	2.59184506
91	positive regulation of heart rate (GO:0010460)	2.58475950
92	negative regulation of T cell differentiation in thymus (GO:0033085)	2.57534584
93	regulation of catecholamine metabolic process (GO:0042069)	2.56860314
94	regulation of dopamine metabolic process (GO:0042053)	2.56860314
95	cellular component biogenesis (GO:0044085)	2.55279440
96	regulation of podosome assembly (GO:0071801)	2.54941766
97	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.53974287
98	organelle disassembly (GO:1903008)	2.53755168
99	positive regulation of smooth muscle contraction (GO:0045987)	2.50803744
100	proton transport (GO:0015992)	2.49998556

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	5.13897512
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.04488026
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.44432639
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.37786882
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.19504246
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.01918301
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.96013734
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89175493
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.85207637
10	VDR_22108803_ChIP-Seq_LS180_Human	2.71434105
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.56892190
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.36535312
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.25589144
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.23516202
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10328680
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.06763495
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.96103481
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93332976
19	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.89140148
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.86639223
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.83953645
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.69717209
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67510123
24	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.67459853
25	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.67459853
26	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.58935609
27	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.51754549
28	GATA3_26560356_Chip-Seq_TH2_Human	1.51257617
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50892414
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.49593579
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49534289
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47949182
33	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.47009164
34	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.45168477
35	EWS_26573619_Chip-Seq_HEK293_Human	1.40290762
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.38633832
37	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.38406068
38	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.34774886
39	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.33847300
40	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.32519610
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.31300655
42	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30770881
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29228173
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.29228173
45	AR_20517297_ChIP-Seq_VCAP_Human	1.28781769
46	FUS_26573619_Chip-Seq_HEK293_Human	1.27388264
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25839934
48	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.25238859
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.24939077
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24890166
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24727742
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21294837
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18325720
54	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.14689472
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14403879
56	NCOR_22424771_ChIP-Seq_293T_Human	1.11581256
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.10933338
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10674646
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10492866
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10492866
61	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.10427708
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09584871
63	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09299279
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08682966
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08005771
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07622460
67	ERA_21632823_ChIP-Seq_H3396_Human	1.06760542
68	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03177958
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02865253
70	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02535604
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02469432
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02266794
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01066420
74	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.00807835
75	GABP_19822575_ChIP-Seq_HepG2_Human	0.99960987
76	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99783367
77	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.99696601
78	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.99566432
79	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99121113
80	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.98963068
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98220496
82	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96084437
83	MYC_19829295_ChIP-Seq_ESCs_Human	0.96005363
84	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.95462432
85	ERG_20517297_ChIP-Seq_VCAP_Human	0.94017756
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.93390840
87	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.93230331
88	P300_19829295_ChIP-Seq_ESCs_Human	0.92766361
89	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.92060721
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.91455437
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91193945
92	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.90698503
93	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.88905350
94	ER_23166858_ChIP-Seq_MCF-7_Human	0.87766626
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.87654069
96	RBPJ_21746931_ChIP-Seq_IB4_Human	0.87267256
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.85975155
98	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.85869821
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.85824568
100	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.85794813

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	5.09276703
2	MP0003252_abnormal_bile_duct	3.11155480
3	MP0006072_abnormal_retinal_apoptosis	2.67885782
4	MP0002163_abnormal_gland_morphology	2.61143053
5	MP0002138_abnormal_hepatobiliary_system	2.59782587
6	MP0002102_abnormal_ear_morphology	2.49175227
7	MP0008872_abnormal_physiological_respon	2.45156418
8	MP0000372_irregular_coat_pigmentation	2.38142754
9	MP0005671_abnormal_response_to	2.28552391
10	MP0002928_abnormal_bile_duct	2.24307987
11	MP0008877_abnormal_DNA_methylation	2.23838280
12	MP0003183_abnormal_peptide_metabolism	2.21950194
13	MP0005084_abnormal_gallbladder_morpholo	2.09207295
14	MP0004147_increased_porphyrin_level	2.02538533
15	MP0004145_abnormal_muscle_electrophysio	2.02239347
16	MP0001835_abnormal_antigen_presentation	1.93444170
17	MP0005379_endocrine/exocrine_gland_phen	1.91163732
18	MP0002837_dystrophic_cardiac_calcinosis	1.84706378
19	MP0002234_abnormal_pharynx_morphology	1.73890739
20	MP0003806_abnormal_nucleotide_metabolis	1.69518865
21	MP0005551_abnormal_eye_electrophysiolog	1.68334481
22	MP0003186_abnormal_redox_activity	1.67738261
23	MP0001905_abnormal_dopamine_level	1.67451406
24	MP0001986_abnormal_taste_sensitivity	1.64700220
25	MP0009379_abnormal_foot_pigmentation	1.64442424
26	MP0004142_abnormal_muscle_tone	1.59012712
27	MP0002148_abnormal_hypersensitivity_rea	1.58818614
28	MP0004043_abnormal_pH_regulation	1.52529594
29	MP0002272_abnormal_nervous_system	1.50575735
30	MP0005083_abnormal_biliary_tract	1.47615880
31	MP0001501_abnormal_sleep_pattern	1.47110329
32	MP0008058_abnormal_DNA_repair	1.46994982
33	MP0003011_delayed_dark_adaptation	1.36092705
34	MP0008775_abnormal_heart_ventricle	1.34480602
35	MP0006036_abnormal_mitochondrial_physio	1.34167457
36	MP0005646_abnormal_pituitary_gland	1.32998896
37	MP0001800_abnormal_humoral_immune	1.32418840
38	MP0005645_abnormal_hypothalamus_physiol	1.29650614
39	MP0003718_maternal_effect	1.29093458
40	MP0006292_abnormal_olfactory_placode	1.28712642
41	MP0005174_abnormal_tail_pigmentation	1.28103058
42	MP0003724_increased_susceptibility_to	1.27235564
43	MP0003786_premature_aging	1.26544718
44	MP0003787_abnormal_imprinting	1.23568922
45	MP0002693_abnormal_pancreas_physiology	1.22107598
46	MP0005389_reproductive_system_phenotype	1.21816086
47	MP0009333_abnormal_splenocyte_physiolog	1.16596332
48	MP0005075_abnormal_melanosome_morpholog	1.15387052
49	MP0002166_altered_tumor_susceptibility	1.14866609
50	MP0005253_abnormal_eye_physiology	1.10518224
51	MP0004885_abnormal_endolymph	1.10477256
52	MP0005000_abnormal_immune_tolerance	1.09662769
53	MP0005636_abnormal_mineral_homeostasis	1.09161791
54	MP0002006_tumorigenesis	1.08168781
55	MP0002653_abnormal_ependyma_morphology	1.08081297
56	MP0003880_abnormal_central_pattern	1.08021062
57	MP0001765_abnormal_ion_homeostasis	1.06976155
58	MP0004215_abnormal_myocardial_fiber	1.06865920
59	MP0009745_abnormal_behavioral_response	1.06008783
60	MP0002160_abnormal_reproductive_system	1.05511911
61	MP0001790_abnormal_immune_system	1.01603003
62	MP0005387_immune_system_phenotype	1.01603003
63	MP0005085_abnormal_gallbladder_physiolo	1.00743707
64	MP0009764_decreased_sensitivity_to	0.99632033
65	MP0005410_abnormal_fertilization	0.96657770
66	MP0001293_anophthalmia	0.96063712
67	MP0002733_abnormal_thermal_nociception	0.95990647
68	MP0002452_abnormal_antigen_presenting	0.94488463
69	MP0002723_abnormal_immune_serum	0.93365031
70	MP0003950_abnormal_plasma_membrane	0.90942359
71	MP0003763_abnormal_thymus_physiology	0.90770498
72	MP0002095_abnormal_skin_pigmentation	0.89884358
73	MP0001485_abnormal_pinna_reflex	0.89007679
74	MP0000230_abnormal_systemic_arterial	0.87104595
75	MP0001968_abnormal_touch/_nociception	0.86138245
76	MP0010329_abnormal_lipoprotein_level	0.85755538
77	MP0001819_abnormal_immune_cell	0.85617710
78	MP0003866_abnormal_defecation	0.85382363
79	MP0002420_abnormal_adaptive_immunity	0.83917863
80	MP0000685_abnormal_immune_system	0.83825600
81	MP0006276_abnormal_autonomic_nervous	0.83662108
82	MP0001873_stomach_inflammation	0.82222927
83	MP0004742_abnormal_vestibular_system	0.81221318
84	MP0001970_abnormal_pain_threshold	0.79884284
85	MP0005360_urolithiasis	0.78828397
86	MP0009697_abnormal_copulation	0.78235680
87	MP0002210_abnormal_sex_determination	0.77398916
88	MP0002572_abnormal_emotion/affect_behav	0.76360023
89	MP0001919_abnormal_reproductive_system	0.76054365
90	MP0008995_early_reproductive_senescence	0.75487254
91	MP0001348_abnormal_lacrimal_gland	0.74544045
92	MP0000569_abnormal_digit_pigmentation	0.74097118
93	MP0002064_seizures	0.73098603
94	MP0002229_neurodegeneration	0.72050427
95	MP0005319_abnormal_enzyme/_coenzyme	0.71298696
96	MP0000015_abnormal_ear_pigmentation	0.70222075
97	MP0009780_abnormal_chondrocyte_physiolo	0.68974827
98	MP0009765_abnormal_xenobiotic_induced	0.68630486
99	MP0003693_abnormal_embryo_hatching	0.68602306
100	MP0000689_abnormal_spleen_morphology	0.67108592

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.14120522
2	Acute necrotizing encephalopathy (HP:0006965)	4.09417223
3	3-Methylglutaconic aciduria (HP:0003535)	4.04890773
4	Abnormal rod and cone electroretinograms (HP:0008323)	3.70744975
5	Acute encephalopathy (HP:0006846)	3.59090618
6	Abnormality of B cell number (HP:0010975)	3.51986466
7	Progressive macrocephaly (HP:0004481)	3.50534513
8	Congenital stationary night blindness (HP:0007642)	3.46272190
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.44803013
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.42919097
11	B lymphocytopenia (HP:0010976)	3.35569273
12	Mitochondrial inheritance (HP:0001427)	3.33775377
13	Pancreatic fibrosis (HP:0100732)	3.20442651
14	Increased CSF lactate (HP:0002490)	3.19813897
15	Abolished electroretinogram (ERG) (HP:0000550)	3.17899412
16	Molar tooth sign on MRI (HP:0002419)	3.17491982
17	Abnormality of midbrain morphology (HP:0002418)	3.17491982
18	Supernumerary spleens (HP:0009799)	3.13868316
19	Abnormality of alanine metabolism (HP:0010916)	3.00453864
20	Hyperalaninemia (HP:0003348)	3.00453864
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.00453864
22	Hepatocellular necrosis (HP:0001404)	2.95259436
23	Pancreatic cysts (HP:0001737)	2.94595796
24	Hepatic necrosis (HP:0002605)	2.94287683
25	Hyperglycinemia (HP:0002154)	2.87293891
26	Bile duct proliferation (HP:0001408)	2.83571049
27	Abnormal biliary tract physiology (HP:0012439)	2.83571049
28	Fair hair (HP:0002286)	2.68874753
29	Aplastic anemia (HP:0001915)	2.65313749
30	Dyschromatopsia (HP:0007641)	2.56218458
31	True hermaphroditism (HP:0010459)	2.55196264
32	Increased serum lactate (HP:0002151)	2.49766398
33	Abnormality of the renal cortex (HP:0011035)	2.49531680
34	Renal cortical cysts (HP:0000803)	2.49387718
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.48967162
36	IgG deficiency (HP:0004315)	2.47896505
37	Type II lissencephaly (HP:0007260)	2.43926039
38	Cerebral edema (HP:0002181)	2.39630860
39	Ketoacidosis (HP:0001993)	2.33276421
40	Severe combined immunodeficiency (HP:0004430)	2.29339670
41	Medial flaring of the eyebrow (HP:0010747)	2.28954597
42	Cerebellar dysplasia (HP:0007033)	2.28008265
43	Hypomagnesemia (HP:0002917)	2.24776465
44	Nephronophthisis (HP:0000090)	2.20805288
45	Colon cancer (HP:0003003)	2.20117663
46	Polydipsia (HP:0001959)	2.17728331
47	Abnormal drinking behavior (HP:0030082)	2.17728331
48	Type 2 muscle fiber atrophy (HP:0003554)	2.17069720
49	Testicular atrophy (HP:0000029)	2.16971813
50	Abnormal respiratory motile cilium morphology (HP:0005938)	2.16896610
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.16896610
52	Abnormality of T cell physiology (HP:0011840)	2.16469915
53	Constricted visual fields (HP:0001133)	2.16291763
54	Hyperglycinuria (HP:0003108)	2.15434680
55	Optic disc pallor (HP:0000543)	2.15169202
56	Abnormality of magnesium homeostasis (HP:0004921)	2.11609200
57	Attenuation of retinal blood vessels (HP:0007843)	2.11357338
58	Thyroiditis (HP:0100646)	2.09426472
59	Abnormality of the labia minora (HP:0012880)	2.09186119
60	Stomatitis (HP:0010280)	2.08803685
61	Lactic acidosis (HP:0003128)	2.06963150
62	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.05994052
63	Lethargy (HP:0001254)	1.99138984
64	Microretrognathia (HP:0000308)	1.99080921
65	Hypoproteinemia (HP:0003075)	1.97891390
66	IgM deficiency (HP:0002850)	1.96356017
67	Cystic liver disease (HP:0006706)	1.95554041
68	Generalized hypopigmentation of hair (HP:0011358)	1.94881571
69	Hyperlipoproteinemia (HP:0010980)	1.94612829
70	Abnormality of T cells (HP:0002843)	1.93829667
71	Panhypogammaglobulinemia (HP:0003139)	1.93061021
72	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.92227760
73	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.92227760
74	Methylmalonic acidemia (HP:0002912)	1.91883753
75	Respiratory failure (HP:0002878)	1.90324073
76	Pendular nystagmus (HP:0012043)	1.88832919
77	Ketosis (HP:0001946)	1.87903320
78	Gaze-evoked nystagmus (HP:0000640)	1.86333709
79	Abnormality of serum amino acid levels (HP:0003112)	1.82579884
80	Type I diabetes mellitus (HP:0100651)	1.82084907
81	Muscle fiber atrophy (HP:0100295)	1.81001263
82	Tubular atrophy (HP:0000092)	1.80765769
83	Asplenia (HP:0001746)	1.80238355
84	Postaxial foot polydactyly (HP:0001830)	1.78915740
85	Tubulointerstitial fibrosis (HP:0005576)	1.76967686
86	Sclerocornea (HP:0000647)	1.76586814
87	Methylmalonic aciduria (HP:0012120)	1.76354373
88	Pustule (HP:0200039)	1.74686624
89	Large for gestational age (HP:0001520)	1.74667945
90	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.73629917
91	Abnormality of the renal medulla (HP:0100957)	1.73279942
92	Chronic sinusitis (HP:0011109)	1.72787076
93	Disproportionate short-trunk short stature (HP:0003521)	1.71133432
94	Nephrogenic diabetes insipidus (HP:0009806)	1.71003201
95	Facial shape deformation (HP:0011334)	1.70723417
96	Potter facies (HP:0002009)	1.70723417
97	Pancytopenia (HP:0001876)	1.70554050
98	Ependymoma (HP:0002888)	1.69655320
99	Impulsivity (HP:0100710)	1.68370150
100	Abnormality of glycine metabolism (HP:0010895)	1.66518958

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.86843163
2	ZAK	3.46918926
3	MST4	3.41518273
4	WNK4	3.22809847
5	EIF2AK3	3.18337313
6	TLK1	3.07406691
7	SCYL2	2.93375215
8	NUAK1	2.72485347
9	EIF2AK1	2.70667069
10	ADRBK2	2.68705285
11	FRK	2.62332570
12	BUB1	2.37625815
13	PASK	2.20476919
14	WNK3	2.08526615
15	TXK	1.93614402
16	STK39	1.91838610
17	VRK2	1.63545846
18	PINK1	1.61912333
19	MKNK1	1.56444881
20	GRK1	1.51279518
21	CAMKK2	1.45337894
22	FES	1.40987492
23	SRPK1	1.30809892
24	BMPR2	1.29683409
25	TESK2	1.27041449
26	NEK1	1.27031198
27	BMPR1B	1.22033352
28	PBK	1.21212784
29	RIPK4	1.20015810
30	MAPKAPK5	1.19435024
31	TNK2	1.15214935
32	STK16	1.14992486
33	OXSR1	1.14255568
34	PLK2	1.10416941
35	PIK3CG	1.09853106
36	PLK4	1.09768171
37	VRK1	1.09706329
38	BCKDK	1.09359100
39	TYRO3	1.08628557
40	INSRR	1.08338893
41	PAK6	0.98469167
42	ITK	0.97552207
43	MAP3K12	0.94743777
44	MAP3K14	0.90426093
45	PHKG2	0.88820768
46	PHKG1	0.88820768
47	KIT	0.87515952
48	CDK8	0.85041678
49	SYK	0.82228283
50	LIMK1	0.81378226
51	EIF2AK2	0.80202274
52	CAMKK1	0.80100420
53	TAF1	0.79184059
54	MAP4K2	0.78558233
55	KDR	0.77322218
56	TEC	0.76415958
57	DYRK2	0.75007547
58	WNK1	0.73148270
59	IKBKB	0.71167973
60	PRKCQ	0.70848449
61	PLK3	0.67418220
62	FLT3	0.65474779
63	TIE1	0.63485565
64	LCK	0.62900054
65	IKBKE	0.60524669
66	IRAK4	0.57510113
67	STK11	0.55419687
68	NME2	0.52772695
69	OBSCN	0.51733589
70	STK38L	0.51683219
71	MKNK2	0.51551967
72	PRKCI	0.50961639
73	DAPK2	0.49104570
74	MAPK13	0.48810045
75	CSK	0.47123702
76	RPS6KA5	0.46634507
77	GRK6	0.43146881
78	TBK1	0.43086431
79	TNIK	0.41042503
80	LYN	0.38121310
81	MAPK11	0.37705813
82	ADRBK1	0.37434449
83	MARK3	0.37212645
84	STK24	0.36921222
85	MAPKAPK3	0.35720895
86	BTK	0.35475153
87	ZAP70	0.35366090
88	PRKCE	0.35239145
89	EPHB2	0.35192826
90	PRKACA	0.34470318
91	CAMK1	0.34175828
92	PRKCZ	0.32457992
93	PLK1	0.30235176
94	ILK	0.27162010
95	AKT2	0.27090988
96	ALK	0.26724777
97	FGFR2	0.26483949
98	PRKCA	0.26303986
99	PAK3	0.25984247
100	CHEK2	0.25314575

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	7.54751481
2	Proteasome_Homo sapiens_hsa03050	3.26461013
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.91892144
4	Protein export_Homo sapiens_hsa03060	2.61170524
5	Parkinsons disease_Homo sapiens_hsa05012	2.34218267
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.27372691
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.21379385
8	Ribosome_Homo sapiens_hsa03010	2.20365483
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.17795160
10	RNA degradation_Homo sapiens_hsa03018	2.09518091
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.00790828
12	Asthma_Homo sapiens_hsa05310	2.00790404
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99114637
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.97470030
15	RNA polymerase_Homo sapiens_hsa03020	1.79397745
16	One carbon pool by folate_Homo sapiens_hsa00670	1.78931548
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.75079026
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.67196542
19	Allograft rejection_Homo sapiens_hsa05330	1.62692228
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.50040619
21	Alzheimers disease_Homo sapiens_hsa05010	1.48174093
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38846894
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.34245756
24	Homologous recombination_Homo sapiens_hsa03440	1.31864039
25	Mismatch repair_Homo sapiens_hsa03430	1.29703137
26	Peroxisome_Homo sapiens_hsa04146	1.28402418
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.27041042
28	Huntingtons disease_Homo sapiens_hsa05016	1.27026754
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20597792
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20040748
31	Butanoate metabolism_Homo sapiens_hsa00650	1.19406461
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17497390
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.17219467
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.16235592
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14651883
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.10883263
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08856798
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.08204262
39	Phototransduction_Homo sapiens_hsa04744	1.07770265
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03836346
41	Antigen processing and presentation_Homo sapiens_hsa04612	1.03097947
42	Type I diabetes mellitus_Homo sapiens_hsa04940	1.02898880
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.02737745
44	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.00349056
45	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.97511413
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84996482
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81207620
48	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.80507481
49	Graft-versus-host disease_Homo sapiens_hsa05332	0.80277547
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.79875932
51	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.77463472
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.75254622
53	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.75164001
54	Folate biosynthesis_Homo sapiens_hsa00790	0.74217540
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.73813987
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73173628
57	Propanoate metabolism_Homo sapiens_hsa00640	0.70263187
58	Spliceosome_Homo sapiens_hsa03040	0.69596046
59	Retinol metabolism_Homo sapiens_hsa00830	0.68850983
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67563153
61	Purine metabolism_Homo sapiens_hsa00230	0.66783146
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66614315
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65065360
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.61582669
65	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.61330368
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.56515214
67	Metabolic pathways_Homo sapiens_hsa01100	0.56310843
68	RNA transport_Homo sapiens_hsa03013	0.53937902
69	Salivary secretion_Homo sapiens_hsa04970	0.53730511
70	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53193600
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52765805
72	Olfactory transduction_Homo sapiens_hsa04740	0.52008622
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51985979
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51918891
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46523933
76	DNA replication_Homo sapiens_hsa03030	0.45960734
77	Basal transcription factors_Homo sapiens_hsa03022	0.42873498
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42083085
79	Regulation of autophagy_Homo sapiens_hsa04140	0.41773066
80	Mineral absorption_Homo sapiens_hsa04978	0.41242628
81	Rheumatoid arthritis_Homo sapiens_hsa05323	0.40313777
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37638884
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.33531405
84	Insulin secretion_Homo sapiens_hsa04911	0.32596341
85	Measles_Homo sapiens_hsa05162	0.32452871
86	Fatty acid elongation_Homo sapiens_hsa00062	0.32072901
87	Nicotine addiction_Homo sapiens_hsa05033	0.30319170
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29560978
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.28690345
90	Serotonergic synapse_Homo sapiens_hsa04726	0.28668193
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.27416964
92	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.27056154
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.25906665
94	Selenocompound metabolism_Homo sapiens_hsa00450	0.25136284
95	Histidine metabolism_Homo sapiens_hsa00340	0.23184874
96	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.22461137
97	Fatty acid degradation_Homo sapiens_hsa00071	0.19862869
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.19629636
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.19510711
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.19420517

RPS4XP15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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