RPS4XP16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.98725681
2viral transcription (GO:0019083)7.89419431
3translational termination (GO:0006415)7.57634971
4ribosomal small subunit biogenesis (GO:0042274)7.22179711
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.40928023
6maturation of SSU-rRNA (GO:0030490)6.40205292
7cotranslational protein targeting to membrane (GO:0006613)6.32122662
8protein targeting to ER (GO:0045047)6.28598643
9translational elongation (GO:0006414)6.26642868
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.02527786
11protein localization to endoplasmic reticulum (GO:0070972)5.94444492
12cellular protein complex disassembly (GO:0043624)5.73072090
13viral life cycle (GO:0019058)5.66635627
14ATP synthesis coupled proton transport (GO:0015986)5.65621424
15energy coupled proton transport, down electrochemical gradient (GO:0015985)5.65621424
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.37239313
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.31120296
18translational initiation (GO:0006413)5.22653940
19protein neddylation (GO:0045116)4.98456610
20protein complex disassembly (GO:0043241)4.83488721
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.66405608
22macromolecular complex disassembly (GO:0032984)4.59794880
23protein complex biogenesis (GO:0070271)4.50666647
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.42200302
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.42200302
26NADH dehydrogenase complex assembly (GO:0010257)4.42200302
27chaperone-mediated protein transport (GO:0072321)4.36542258
28DNA deamination (GO:0045006)4.33102921
29positive regulation of catecholamine secretion (GO:0033605)4.28332786
30protein targeting to membrane (GO:0006612)4.22498685
31positive regulation of amino acid transport (GO:0051957)4.16430891
32mitochondrial respiratory chain complex assembly (GO:0033108)4.11493703
33translation (GO:0006412)4.08739557
34respiratory electron transport chain (GO:0022904)4.07394484
35establishment of protein localization to mitochondrial membrane (GO:0090151)4.05604640
36electron transport chain (GO:0022900)4.04607172
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.97594776
38ribosomal large subunit biogenesis (GO:0042273)3.95346238
39behavioral response to nicotine (GO:0035095)3.95146839
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.86973770
41epithelial cilium movement (GO:0003351)3.81463452
42nuclear-transcribed mRNA catabolic process (GO:0000956)3.80804728
43mRNA catabolic process (GO:0006402)3.58084454
44preassembly of GPI anchor in ER membrane (GO:0016254)3.41415736
45cytidine deamination (GO:0009972)3.39230763
46cytidine metabolic process (GO:0046087)3.39230763
47cytidine catabolic process (GO:0006216)3.39230763
48cellular component biogenesis (GO:0044085)3.37503631
49ATP biosynthetic process (GO:0006754)3.33030927
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28328344
51pyrimidine nucleotide catabolic process (GO:0006244)3.27899639
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20769771
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19558071
54negative regulation of telomere maintenance (GO:0032205)3.19040787
55RNA catabolic process (GO:0006401)3.18367848
56sequestering of actin monomers (GO:0042989)3.18106815
57serotonin receptor signaling pathway (GO:0007210)3.17861292
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16461581
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16461581
60ribonucleoprotein complex biogenesis (GO:0022613)3.15943954
61base-excision repair, AP site formation (GO:0006285)3.14115693
62GTP biosynthetic process (GO:0006183)3.13436830
63negative regulation of neurotransmitter secretion (GO:0046929)3.12662444
64negative regulation of amino acid transport (GO:0051956)3.06954066
65cilium movement (GO:0003341)3.06561986
66exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05481304
67hydrogen ion transmembrane transport (GO:1902600)3.04203287
68deoxyribonucleotide catabolic process (GO:0009264)3.03434237
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96116116
70proton transport (GO:0015992)2.94404212
71somite development (GO:0061053)2.91570507
72pyrimidine ribonucleoside catabolic process (GO:0046133)2.90838346
73cullin deneddylation (GO:0010388)2.89738172
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88514025
75hydrogen transport (GO:0006818)2.87349313
76ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82933566
77establishment of protein localization to membrane (GO:0090150)2.82882191
78regulation of glutamate secretion (GO:0014048)2.80267420
79protein targeting (GO:0006605)2.80165725
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.79881974
81termination of RNA polymerase III transcription (GO:0006386)2.79881974
82protein deneddylation (GO:0000338)2.79794807
83deoxyribose phosphate catabolic process (GO:0046386)2.78477259
84peptidyl-histidine modification (GO:0018202)2.78209172
85metallo-sulfur cluster assembly (GO:0031163)2.72735241
86iron-sulfur cluster assembly (GO:0016226)2.72735241
87proteasome assembly (GO:0043248)2.66582942
88axoneme assembly (GO:0035082)2.62908357
89GPI anchor metabolic process (GO:0006505)2.62178587
90intracellular protein transmembrane import (GO:0044743)2.61829377
91regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59294548
92positive regulation of organic acid transport (GO:0032892)2.59184866
93establishment of protein localization to organelle (GO:0072594)2.58109895
94UTP biosynthetic process (GO:0006228)2.57718890
95nucleoside triphosphate biosynthetic process (GO:0009142)2.57375406
96GPI anchor biosynthetic process (GO:0006506)2.52728972
97forebrain morphogenesis (GO:0048853)2.52680255
98branched-chain amino acid catabolic process (GO:0009083)2.52269508
99regulation of dopamine secretion (GO:0014059)2.51999611
100phospholipid scrambling (GO:0017121)2.51600204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.94761939
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.89584482
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.72034476
4VDR_22108803_ChIP-Seq_LS180_Human3.44454352
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.27989956
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.20046742
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03624890
8ZNF274_21170338_ChIP-Seq_K562_Hela2.61970453
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.55812192
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50541617
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49448645
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42894126
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38753512
14VDR_23849224_ChIP-Seq_CD4+_Human2.33525887
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27060209
16FUS_26573619_Chip-Seq_HEK293_Human2.25868309
17EWS_26573619_Chip-Seq_HEK293_Human2.23776876
18IGF1R_20145208_ChIP-Seq_DFB_Human2.15213525
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.06424861
20ELK1_19687146_ChIP-ChIP_HELA_Human2.06232357
21FOXP3_21729870_ChIP-Seq_TREG_Human2.03917175
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.99392222
23MYC_18940864_ChIP-ChIP_HL60_Human1.97599480
24EZH2_22144423_ChIP-Seq_EOC_Human1.89200716
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82830405
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.80454577
27IRF1_19129219_ChIP-ChIP_H3396_Human1.79279713
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.78636295
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61205790
30TP53_22573176_ChIP-Seq_HFKS_Human1.56994607
31TTF2_22483619_ChIP-Seq_HELA_Human1.54687753
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54341305
33GBX2_23144817_ChIP-Seq_PC3_Human1.54022519
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53302192
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.51016536
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50382355
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49522034
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47196381
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43813721
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.42250413
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41737301
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40829718
43ER_23166858_ChIP-Seq_MCF-7_Human1.36261726
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.32351382
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.30826895
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30271117
47NANOG_20526341_ChIP-Seq_ESCs_Human1.29884869
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29594445
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.27616522
50P300_19829295_ChIP-Seq_ESCs_Human1.27065149
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25828735
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22155391
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21977099
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.21778005
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21778005
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19439824
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17310609
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15354684
59NCOR_22424771_ChIP-Seq_293T_Human1.12806285
60SOX2_19829295_ChIP-Seq_ESCs_Human1.12529489
61NANOG_19829295_ChIP-Seq_ESCs_Human1.12529489
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12201070
63CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10954970
64RNF2_27304074_Chip-Seq_NSC_Mouse1.10951181
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.10589697
66XRN2_22483619_ChIP-Seq_HELA_Human1.09846263
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08858411
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08386124
69AR_20517297_ChIP-Seq_VCAP_Human1.07508465
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07221703
71ERA_21632823_ChIP-Seq_H3396_Human1.07155499
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06263305
73GATA3_26560356_Chip-Seq_TH2_Human1.05478187
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.05310058
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03210202
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00902424
77TAF2_19829295_ChIP-Seq_ESCs_Human1.00784576
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00281741
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99798266
80GABP_19822575_ChIP-Seq_HepG2_Human0.96142314
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95491380
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95227616
83CIITA_25753668_ChIP-Seq_RAJI_Human0.95092976
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94705569
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94616439
86MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93761102
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93140068
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92993195
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92124363
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91957109
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90355370
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89813333
93HTT_18923047_ChIP-ChIP_STHdh_Human0.89262815
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88830292
95DCP1A_22483619_ChIP-Seq_HELA_Human0.87875536
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85917286
97ERG_20517297_ChIP-Seq_VCAP_Human0.85841747
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84352879
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83936629
100CBP_20019798_ChIP-Seq_JUKART_Human0.83936629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.90183971
2MP0006292_abnormal_olfactory_placode3.59864446
3MP0002163_abnormal_gland_morphology2.74691478
4MP0002234_abnormal_pharynx_morphology2.60670963
5MP0002822_catalepsy2.40952854
6MP0008995_early_reproductive_senescence2.27206868
7MP0004142_abnormal_muscle_tone2.17151021
8MP0006072_abnormal_retinal_apoptosis2.13328430
9MP0000049_abnormal_middle_ear2.12257474
10MP0005646_abnormal_pituitary_gland1.94140529
11MP0002837_dystrophic_cardiac_calcinosis1.91187807
12MP0003011_delayed_dark_adaptation1.89570952
13MP0003195_calcinosis1.82404834
14MP0008961_abnormal_basal_metabolism1.78891274
15MP0001986_abnormal_taste_sensitivity1.74366263
16MP0008875_abnormal_xenobiotic_pharmacok1.70403380
17MP0008058_abnormal_DNA_repair1.66041318
18MP0005084_abnormal_gallbladder_morpholo1.64047256
19MP0000631_abnormal_neuroendocrine_gland1.60818619
20MP0006276_abnormal_autonomic_nervous1.59921820
21MP0006036_abnormal_mitochondrial_physio1.57841001
22MP0005671_abnormal_response_to1.57166789
23MP0001188_hyperpigmentation1.56831389
24MP0003186_abnormal_redox_activity1.55166011
25MP0005379_endocrine/exocrine_gland_phen1.54965424
26MP0001293_anophthalmia1.54785769
27MP0001529_abnormal_vocalization1.52415356
28MP0001905_abnormal_dopamine_level1.51783879
29MP0002277_abnormal_respiratory_mucosa1.48685340
30MP0005551_abnormal_eye_electrophysiolog1.45403343
31MP0008872_abnormal_physiological_respon1.44705690
32MP0004885_abnormal_endolymph1.43206964
33MP0002102_abnormal_ear_morphology1.41490956
34MP0003786_premature_aging1.38624596
35MP0003122_maternal_imprinting1.34409112
36MP0005253_abnormal_eye_physiology1.29196530
37MP0001968_abnormal_touch/_nociception1.26977124
38MP0002735_abnormal_chemical_nociception1.21478387
39MP0002138_abnormal_hepatobiliary_system1.21297308
40MP0005645_abnormal_hypothalamus_physiol1.20036682
41MP0008877_abnormal_DNA_methylation1.18575485
42MP0000372_irregular_coat_pigmentation1.15677305
43MP0002638_abnormal_pupillary_reflex1.13460976
44MP0003787_abnormal_imprinting1.13261526
45MP0005410_abnormal_fertilization1.12276247
46MP0005389_reproductive_system_phenotype1.11228807
47MP0002736_abnormal_nociception_after1.10280339
48MP0001485_abnormal_pinna_reflex1.09741079
49MP0001835_abnormal_antigen_presentation1.06557593
50MP0003136_yellow_coat_color1.06087279
51MP0002160_abnormal_reproductive_system1.05978306
52MP0001348_abnormal_lacrimal_gland1.05709794
53MP0009745_abnormal_behavioral_response1.04535214
54MP0003880_abnormal_central_pattern1.02893161
55MP0002876_abnormal_thyroid_physiology1.02337628
56MP0000685_abnormal_immune_system1.02039456
57MP0002938_white_spotting1.01211193
58MP0003938_abnormal_ear_development1.00528552
59MP0003121_genomic_imprinting1.00063942
60MP0000613_abnormal_salivary_gland0.98561625
61MP0004742_abnormal_vestibular_system0.98412534
62MP0005387_immune_system_phenotype0.94859724
63MP0001790_abnormal_immune_system0.94859724
64MP0005464_abnormal_platelet_physiology0.93936278
65MP0005075_abnormal_melanosome_morpholog0.93408184
66MP0002733_abnormal_thermal_nociception0.92273153
67MP0004484_altered_response_of0.91236690
68MP0002653_abnormal_ependyma_morphology0.90681109
69MP0002272_abnormal_nervous_system0.90514321
70MP0008789_abnormal_olfactory_epithelium0.89904715
71MP0001764_abnormal_homeostasis0.88614046
72MP0006035_abnormal_mitochondrial_morpho0.86435966
73MP0000230_abnormal_systemic_arterial0.85871768
74MP0005195_abnormal_posterior_eye0.84129090
75MP0001970_abnormal_pain_threshold0.84019515
76MP0002132_abnormal_respiratory_system0.82783504
77MP0010030_abnormal_orbit_morphology0.82645172
78MP0002210_abnormal_sex_determination0.82338736
79MP0005174_abnormal_tail_pigmentation0.81969976
80MP0002095_abnormal_skin_pigmentation0.81848045
81MP0001919_abnormal_reproductive_system0.81771928
82MP0001800_abnormal_humoral_immune0.81400826
83MP0002928_abnormal_bile_duct0.79597538
84MP0009697_abnormal_copulation0.79402052
85MP0002148_abnormal_hypersensitivity_rea0.76876900
86MP0003878_abnormal_ear_physiology0.75737562
87MP0005377_hearing/vestibular/ear_phenot0.75737562
88MP0000026_abnormal_inner_ear0.75480558
89MP0001929_abnormal_gametogenesis0.75427657
90MP0001879_abnormal_lymphatic_vessel0.74932173
91MP0003119_abnormal_digestive_system0.73694802
92MP0005391_vision/eye_phenotype0.73193127
93MP0009046_muscle_twitch0.73132194
94MP0002282_abnormal_trachea_morphology0.71484953
95MP0000653_abnormal_sex_gland0.70470800
96MP0001664_abnormal_digestion0.69987851
97MP0003698_abnormal_male_reproductive0.69874198
98MP0001984_abnormal_olfaction0.69570522
99MP0002557_abnormal_social/conspecific_i0.67156196
100MP0002693_abnormal_pancreas_physiology0.66990881

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.75011624
2Acute necrotizing encephalopathy (HP:0006965)4.63991310
3Abnormality of cells of the erythroid lineage (HP:0012130)4.58077086
4Mitochondrial inheritance (HP:0001427)4.39551865
5Abnormal number of erythroid precursors (HP:0012131)4.19968159
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.16658717
7Abnormal mitochondria in muscle tissue (HP:0008316)4.11092616
8Increased hepatocellular lipid droplets (HP:0006565)4.08643919
9Acute encephalopathy (HP:0006846)3.94922780
10Progressive macrocephaly (HP:0004481)3.85869470
11Renal Fanconi syndrome (HP:0001994)3.79419614
12Lipid accumulation in hepatocytes (HP:0006561)3.77121169
133-Methylglutaconic aciduria (HP:0003535)3.73587789
14Increased CSF lactate (HP:0002490)3.68947682
15Cerebral edema (HP:0002181)3.66008389
16Hepatocellular necrosis (HP:0001404)3.63876534
17Macrocytic anemia (HP:0001972)3.58458540
18Pancreatic fibrosis (HP:0100732)3.53482067
19Pancreatic cysts (HP:0001737)3.45688845
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.39316591
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.39316591
22Hepatic necrosis (HP:0002605)3.29738669
23Abnormal rod and cone electroretinograms (HP:0008323)3.27457404
24Increased intramyocellular lipid droplets (HP:0012240)3.23230132
25Abnormality of midbrain morphology (HP:0002418)2.98197705
26Molar tooth sign on MRI (HP:0002419)2.98197705
27Pallor (HP:0000980)2.97689324
28Optic disc pallor (HP:0000543)2.94220041
29Abnormal ciliary motility (HP:0012262)2.89320139
30Methylmalonic acidemia (HP:0002912)2.82270218
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.74293446
32Absent/shortened dynein arms (HP:0200106)2.74293446
33Abnormal respiratory epithelium morphology (HP:0012253)2.73062757
34Abnormal respiratory motile cilium morphology (HP:0005938)2.73062757
35Increased muscle lipid content (HP:0009058)2.70728528
36Exertional dyspnea (HP:0002875)2.70631989
37True hermaphroditism (HP:0010459)2.70081688
38Abnormality of renal resorption (HP:0011038)2.69929703
39Congenital stationary night blindness (HP:0007642)2.61938217
40Lactic acidosis (HP:0003128)2.61605331
41Stenosis of the external auditory canal (HP:0000402)2.58105064
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.56229444
43Abnormality of the renal collecting system (HP:0004742)2.49068574
44Abnormal respiratory motile cilium physiology (HP:0012261)2.43375941
45Increased serum lactate (HP:0002151)2.40949547
46Chronic hepatic failure (HP:0100626)2.40397784
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38593351
48Lethargy (HP:0001254)2.31742659
49Nephronophthisis (HP:0000090)2.30306040
50Respiratory failure (HP:0002878)2.29060295
51Ketosis (HP:0001946)2.28302268
52Short 1st metacarpal (HP:0010034)2.27429466
53Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.27429466
54Colon cancer (HP:0003003)2.26309271
55Medial flaring of the eyebrow (HP:0010747)2.23693322
56Absent thumb (HP:0009777)2.22506317
57Abnormal hemoglobin (HP:0011902)2.20948909
58Methylmalonic aciduria (HP:0012120)2.17407774
59Hyperglycinemia (HP:0002154)2.15673404
60Abnormality of urine glucose concentration (HP:0011016)2.15372622
61Glycosuria (HP:0003076)2.15372622
62Pendular nystagmus (HP:0012043)2.14597796
63Respiratory difficulties (HP:0002880)2.13434913
64Asplenia (HP:0001746)2.09075346
65Abnormal biliary tract physiology (HP:0012439)2.06135527
66Bile duct proliferation (HP:0001408)2.06135527
67Constricted visual fields (HP:0001133)2.06087806
68Aplasia/Hypoplasia of the spleen (HP:0010451)2.05503735
69Decreased central vision (HP:0007663)2.04186735
70Elevated erythrocyte sedimentation rate (HP:0003565)2.03917588
71Cystic liver disease (HP:0006706)2.01585657
72Abnormality of the 1st metacarpal (HP:0010009)2.01331350
73Exercise intolerance (HP:0003546)2.01092499
74Abnormality of the renal cortex (HP:0011035)1.98290180
75Abnormality of the renal medulla (HP:0100957)1.92690389
76Hyperphosphaturia (HP:0003109)1.92185137
77Type II lissencephaly (HP:0007260)1.91013810
78Aplasia/hypoplasia of the uterus (HP:0008684)1.90998541
79Delayed CNS myelination (HP:0002188)1.86734559
80Septo-optic dysplasia (HP:0100842)1.84774335
81Leukodystrophy (HP:0002415)1.84282365
82Sclerocornea (HP:0000647)1.84170411
83Congenital hepatic fibrosis (HP:0002612)1.81366380
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79516052
85Depressed nasal ridge (HP:0000457)1.76633512
86Hypoplasia of the radius (HP:0002984)1.75500606
87Anencephaly (HP:0002323)1.73678827
88Hypoplasia of the uterus (HP:0000013)1.72667954
89Male pseudohermaphroditism (HP:0000037)1.72103228
90Chronic sinusitis (HP:0011109)1.70709816
91Abolished electroretinogram (ERG) (HP:0000550)1.69879518
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69065104
93Abnormality of alanine metabolism (HP:0010916)1.69065104
94Hyperalaninemia (HP:0003348)1.69065104
95Attenuation of retinal blood vessels (HP:0007843)1.67580860
96Polydipsia (HP:0001959)1.67097699
97Abnormal drinking behavior (HP:0030082)1.67097699
98Aplasia/Hypoplasia of the hallux (HP:0008362)1.64793172
99Short hallux (HP:0010109)1.64265518
100Triphalangeal thumb (HP:0001199)1.63662644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.73436780
2PINK12.65684168
3MAP2K72.52389672
4TLK12.47750736
5STK162.45858645
6NME22.29285541
7NUAK12.07735297
8MAP4K22.01378363
9FRK1.91099521
10VRK21.90697753
11ADRBK21.89129664
12TAOK31.81483595
13GRK11.80719797
14EIF2AK31.78128918
15WNK41.77526029
16MAP3K41.75211659
17TRIM281.72057171
18TXK1.69456416
19WNK31.59921249
20ZAK1.55589176
21BMPR1B1.51132189
22VRK11.37726258
23BUB11.31487388
24CDK191.30445799
25TEC1.20703495
26CDK81.20386967
27DAPK21.20073120
28DYRK21.19004168
29IKBKB1.17554803
30GRK61.11390145
31NEK21.10594534
32RPS6KA41.09677388
33MAP4K11.02769240
34TIE10.99146376
35MAPK130.98023441
36TGFBR10.96685921
37AKT30.93747177
38BTK0.88501257
39MYLK0.85562951
40PRKCQ0.83739314
41TNK20.79545372
42DAPK30.74955417
43OBSCN0.74246611
44ITK0.69168174
45NME10.68575574
46ADRBK10.67621909
47TNIK0.65252552
48IKBKE0.65010869
49PASK0.63651820
50CDC70.63379726
51KIT0.62205130
52RPS6KA50.59422390
53FES0.59197246
54DYRK30.56414929
55PIM10.54119512
56SYK0.53972343
57PRKCG0.51999793
58GRK70.51164580
59KDR0.50731734
60ILK0.50654930
61MAP3K100.50180300
62AURKA0.49252973
63CSNK2A20.49210977
64INSRR0.49009260
65EPHB20.48709669
66CSNK1G30.48392936
67SIK20.48269650
68PAK30.47748834
69CDK30.47530536
70MARK30.47520861
71MAP2K60.47413956
72FGFR20.46700374
73BRAF0.46189640
74GRK50.45744449
75DAPK10.45663657
76PIK3CG0.45613907
77MAPK150.43973735
78AURKB0.43251425
79FLT30.43040498
80PRKCD0.42162594
81BCR0.42076685
82SGK2230.41779305
83SGK4940.41779305
84PRKCE0.41729690
85MAP2K40.41695707
86PLK20.39029116
87CSNK2A10.38401605
88PRKACA0.38342688
89CSNK1G20.36752874
90LRRK20.36643940
91CSNK1A1L0.35764319
92LYN0.33804420
93CAMK10.32629636
94STK390.31963907
95CSF1R0.30917597
96CSNK1A10.29908607
97STK40.28471817
98PAK10.26667809
99MAPKAPK50.26165304
100PLK40.26066826

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.47975977
2Oxidative phosphorylation_Homo sapiens_hsa001904.28526645
3Parkinsons disease_Homo sapiens_hsa050123.62627037
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53247679
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.45059004
6Huntingtons disease_Homo sapiens_hsa050162.36553351
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.32189702
8Alzheimers disease_Homo sapiens_hsa050102.30498496
9RNA polymerase_Homo sapiens_hsa030202.23765849
10Sulfur relay system_Homo sapiens_hsa041222.16795617
11Propanoate metabolism_Homo sapiens_hsa006402.04177616
12Proteasome_Homo sapiens_hsa030501.92746907
13Asthma_Homo sapiens_hsa053101.89212598
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84525005
15Cardiac muscle contraction_Homo sapiens_hsa042601.84051711
16Graft-versus-host disease_Homo sapiens_hsa053321.71423312
17Linoleic acid metabolism_Homo sapiens_hsa005911.66460688
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.65277637
19Allograft rejection_Homo sapiens_hsa053301.60894863
20Protein export_Homo sapiens_hsa030601.54298396
21Autoimmune thyroid disease_Homo sapiens_hsa053201.52689694
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45829245
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.45795693
24Homologous recombination_Homo sapiens_hsa034401.31661108
25Peroxisome_Homo sapiens_hsa041461.22240156
26Type I diabetes mellitus_Homo sapiens_hsa049401.21990874
27Pyrimidine metabolism_Homo sapiens_hsa002401.18462474
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17471126
29Fanconi anemia pathway_Homo sapiens_hsa034601.17073277
30Nitrogen metabolism_Homo sapiens_hsa009101.15653472
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15485651
32RNA degradation_Homo sapiens_hsa030181.14682626
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12252089
34Nucleotide excision repair_Homo sapiens_hsa034201.12025806
35Phototransduction_Homo sapiens_hsa047441.11031714
36Purine metabolism_Homo sapiens_hsa002301.05649956
37Mismatch repair_Homo sapiens_hsa034301.04463660
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03395255
39Primary immunodeficiency_Homo sapiens_hsa053401.01748489
40Chemical carcinogenesis_Homo sapiens_hsa052041.00729450
41Base excision repair_Homo sapiens_hsa034100.98154964
42Basal transcription factors_Homo sapiens_hsa030220.95814113
43One carbon pool by folate_Homo sapiens_hsa006700.93292185
44Arachidonic acid metabolism_Homo sapiens_hsa005900.92957067
45Regulation of autophagy_Homo sapiens_hsa041400.90709625
46Tryptophan metabolism_Homo sapiens_hsa003800.86645513
47Butanoate metabolism_Homo sapiens_hsa006500.86227406
48Retinol metabolism_Homo sapiens_hsa008300.85221002
49Olfactory transduction_Homo sapiens_hsa047400.85097866
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83780374
51Spliceosome_Homo sapiens_hsa030400.83240474
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82175271
53Folate biosynthesis_Homo sapiens_hsa007900.81689840
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.79888666
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79864068
56Collecting duct acid secretion_Homo sapiens_hsa049660.75769388
57Caffeine metabolism_Homo sapiens_hsa002320.73617337
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73590684
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67506559
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66751503
61Metabolic pathways_Homo sapiens_hsa011000.66486903
62Ether lipid metabolism_Homo sapiens_hsa005650.62571804
63Systemic lupus erythematosus_Homo sapiens_hsa053220.62219772
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61074017
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59609055
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59320092
67DNA replication_Homo sapiens_hsa030300.59184905
68Serotonergic synapse_Homo sapiens_hsa047260.56688091
69Hematopoietic cell lineage_Homo sapiens_hsa046400.56468429
70Rheumatoid arthritis_Homo sapiens_hsa053230.55430239
71Taste transduction_Homo sapiens_hsa047420.52130901
72Nicotine addiction_Homo sapiens_hsa050330.51433405
73Antigen processing and presentation_Homo sapiens_hsa046120.50926785
74Glutathione metabolism_Homo sapiens_hsa004800.49217527
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48968827
76Fatty acid elongation_Homo sapiens_hsa000620.44443981
77Fat digestion and absorption_Homo sapiens_hsa049750.44008804
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43581972
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42286964
80Ovarian steroidogenesis_Homo sapiens_hsa049130.42233118
81Starch and sucrose metabolism_Homo sapiens_hsa005000.39555260
82Morphine addiction_Homo sapiens_hsa050320.39343603
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37136922
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.36305411
85RNA transport_Homo sapiens_hsa030130.35630947
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33738456
87beta-Alanine metabolism_Homo sapiens_hsa004100.33194338
88Dorso-ventral axis formation_Homo sapiens_hsa043200.32255551
89Fatty acid degradation_Homo sapiens_hsa000710.31602963
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30594392
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29264329
92Salivary secretion_Homo sapiens_hsa049700.27540743
93N-Glycan biosynthesis_Homo sapiens_hsa005100.27081280
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.26610389
95Tyrosine metabolism_Homo sapiens_hsa003500.26262542
96Hedgehog signaling pathway_Homo sapiens_hsa043400.25033541
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.22041222
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21186463
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20226832
100Alcoholism_Homo sapiens_hsa050340.20185315

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