ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.98725681
2	viral transcription (GO:0019083)	7.89419431
3	translational termination (GO:0006415)	7.57634971
4	ribosomal small subunit biogenesis (GO:0042274)	7.22179711
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.40928023
6	maturation of SSU-rRNA (GO:0030490)	6.40205292
7	cotranslational protein targeting to membrane (GO:0006613)	6.32122662
8	protein targeting to ER (GO:0045047)	6.28598643
9	translational elongation (GO:0006414)	6.26642868
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.02527786
11	protein localization to endoplasmic reticulum (GO:0070972)	5.94444492
12	cellular protein complex disassembly (GO:0043624)	5.73072090
13	viral life cycle (GO:0019058)	5.66635627
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.65621424
15	ATP synthesis coupled proton transport (GO:0015986)	5.65621424
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.37239313
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.31120296
18	translational initiation (GO:0006413)	5.22653940
19	protein neddylation (GO:0045116)	4.98456610
20	protein complex disassembly (GO:0043241)	4.83488721
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.66405608
22	macromolecular complex disassembly (GO:0032984)	4.59794880
23	protein complex biogenesis (GO:0070271)	4.50666647
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.42200302
25	NADH dehydrogenase complex assembly (GO:0010257)	4.42200302
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.42200302
27	chaperone-mediated protein transport (GO:0072321)	4.36542258
28	DNA deamination (GO:0045006)	4.33102921
29	positive regulation of catecholamine secretion (GO:0033605)	4.28332786
30	protein targeting to membrane (GO:0006612)	4.22498685
31	positive regulation of amino acid transport (GO:0051957)	4.16430891
32	mitochondrial respiratory chain complex assembly (GO:0033108)	4.11493703
33	translation (GO:0006412)	4.08739557
34	respiratory electron transport chain (GO:0022904)	4.07394484
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.05604640
36	electron transport chain (GO:0022900)	4.04607172
37	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.97594776
38	ribosomal large subunit biogenesis (GO:0042273)	3.95346238
39	behavioral response to nicotine (GO:0035095)	3.95146839
40	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.86973770
41	epithelial cilium movement (GO:0003351)	3.81463452
42	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.80804728
43	mRNA catabolic process (GO:0006402)	3.58084454
44	preassembly of GPI anchor in ER membrane (GO:0016254)	3.41415736
45	cytidine metabolic process (GO:0046087)	3.39230763
46	cytidine catabolic process (GO:0006216)	3.39230763
47	cytidine deamination (GO:0009972)	3.39230763
48	cellular component biogenesis (GO:0044085)	3.37503631
49	ATP biosynthetic process (GO:0006754)	3.33030927
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.28328344
51	pyrimidine nucleotide catabolic process (GO:0006244)	3.27899639
52	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.20769771
53	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.19558071
54	negative regulation of telomere maintenance (GO:0032205)	3.19040787
55	RNA catabolic process (GO:0006401)	3.18367848
56	sequestering of actin monomers (GO:0042989)	3.18106815
57	serotonin receptor signaling pathway (GO:0007210)	3.17861292
58	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.16461581
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.16461581
60	ribonucleoprotein complex biogenesis (GO:0022613)	3.15943954
61	base-excision repair, AP site formation (GO:0006285)	3.14115693
62	GTP biosynthetic process (GO:0006183)	3.13436830
63	negative regulation of neurotransmitter secretion (GO:0046929)	3.12662444
64	negative regulation of amino acid transport (GO:0051956)	3.06954066
65	cilium movement (GO:0003341)	3.06561986
66	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.05481304
67	hydrogen ion transmembrane transport (GO:1902600)	3.04203287
68	deoxyribonucleotide catabolic process (GO:0009264)	3.03434237
69	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.96116116
70	proton transport (GO:0015992)	2.94404212
71	somite development (GO:0061053)	2.91570507
72	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.90838346
73	cullin deneddylation (GO:0010388)	2.89738172
74	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.88514025
75	hydrogen transport (GO:0006818)	2.87349313
76	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.82933566
77	establishment of protein localization to membrane (GO:0090150)	2.82882191
78	regulation of glutamate secretion (GO:0014048)	2.80267420
79	protein targeting (GO:0006605)	2.80165725
80	termination of RNA polymerase III transcription (GO:0006386)	2.79881974
81	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.79881974
82	protein deneddylation (GO:0000338)	2.79794807
83	deoxyribose phosphate catabolic process (GO:0046386)	2.78477259
84	peptidyl-histidine modification (GO:0018202)	2.78209172
85	iron-sulfur cluster assembly (GO:0016226)	2.72735241
86	metallo-sulfur cluster assembly (GO:0031163)	2.72735241
87	proteasome assembly (GO:0043248)	2.66582942
88	axoneme assembly (GO:0035082)	2.62908357
89	GPI anchor metabolic process (GO:0006505)	2.62178587
90	intracellular protein transmembrane import (GO:0044743)	2.61829377
91	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.59294548
92	positive regulation of organic acid transport (GO:0032892)	2.59184866
93	establishment of protein localization to organelle (GO:0072594)	2.58109895
94	UTP biosynthetic process (GO:0006228)	2.57718890
95	nucleoside triphosphate biosynthetic process (GO:0009142)	2.57375406
96	GPI anchor biosynthetic process (GO:0006506)	2.52728972
97	forebrain morphogenesis (GO:0048853)	2.52680255
98	branched-chain amino acid catabolic process (GO:0009083)	2.52269508
99	regulation of dopamine secretion (GO:0014059)	2.51999611
100	phospholipid scrambling (GO:0017121)	2.51600204

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.94761939
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.89584482
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.72034476
4	VDR_22108803_ChIP-Seq_LS180_Human	3.44454352
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.27989956
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.20046742
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.03624890
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.61970453
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55812192
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.50541617
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.49448645
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42894126
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.38753512
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.33525887
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.27060209
16	FUS_26573619_Chip-Seq_HEK293_Human	2.25868309
17	EWS_26573619_Chip-Seq_HEK293_Human	2.23776876
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15213525
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.06424861
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.06232357
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.03917175
22	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.99392222
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.97599480
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.89200716
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82830405
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.80454577
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.79279713
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78636295
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.61205790
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.56994607
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.54687753
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.54341305
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.54022519
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53302192
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.51016536
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.50382355
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49522034
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.47196381
39	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.43813721
40	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.42250413
41	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.41737301
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40829718
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.36261726
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32351382
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30826895
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30271117
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.29884869
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.29594445
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.27616522
50	P300_19829295_ChIP-Seq_ESCs_Human	1.27065149
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.25828735
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22155391
53	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.21977099
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21778005
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21778005
56	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.19439824
57	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.17310609
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15354684
59	NCOR_22424771_ChIP-Seq_293T_Human	1.12806285
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12529489
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12529489
62	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12201070
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10954970
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10951181
65	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10589697
66	XRN2_22483619_ChIP-Seq_HELA_Human	1.09846263
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08858411
68	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08386124
69	AR_20517297_ChIP-Seq_VCAP_Human	1.07508465
70	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.07221703
71	ERA_21632823_ChIP-Seq_H3396_Human	1.07155499
72	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.06263305
73	GATA3_26560356_Chip-Seq_TH2_Human	1.05478187
74	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.05310058
75	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.03210202
76	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.00902424
77	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00784576
78	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00281741
79	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.99798266
80	GABP_19822575_ChIP-Seq_HepG2_Human	0.96142314
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95491380
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95227616
83	CIITA_25753668_ChIP-Seq_RAJI_Human	0.95092976
84	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.94705569
85	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94616439
86	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.93761102
87	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.93140068
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92993195
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92124363
90	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.91957109
91	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.90355370
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89813333
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.89262815
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.88830292
95	DCP1A_22483619_ChIP-Seq_HELA_Human	0.87875536
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.85917286
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.85841747
98	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.84352879
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.83936629
100	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.83936629

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.90183971
2	MP0006292_abnormal_olfactory_placode	3.59864446
3	MP0002163_abnormal_gland_morphology	2.74691478
4	MP0002234_abnormal_pharynx_morphology	2.60670963
5	MP0002822_catalepsy	2.40952854
6	MP0008995_early_reproductive_senescence	2.27206868
7	MP0004142_abnormal_muscle_tone	2.17151021
8	MP0006072_abnormal_retinal_apoptosis	2.13328430
9	MP0000049_abnormal_middle_ear	2.12257474
10	MP0005646_abnormal_pituitary_gland	1.94140529
11	MP0002837_dystrophic_cardiac_calcinosis	1.91187807
12	MP0003011_delayed_dark_adaptation	1.89570952
13	MP0003195_calcinosis	1.82404834
14	MP0008961_abnormal_basal_metabolism	1.78891274
15	MP0001986_abnormal_taste_sensitivity	1.74366263
16	MP0008875_abnormal_xenobiotic_pharmacok	1.70403380
17	MP0008058_abnormal_DNA_repair	1.66041318
18	MP0005084_abnormal_gallbladder_morpholo	1.64047256
19	MP0000631_abnormal_neuroendocrine_gland	1.60818619
20	MP0006276_abnormal_autonomic_nervous	1.59921820
21	MP0006036_abnormal_mitochondrial_physio	1.57841001
22	MP0005671_abnormal_response_to	1.57166789
23	MP0001188_hyperpigmentation	1.56831389
24	MP0003186_abnormal_redox_activity	1.55166011
25	MP0005379_endocrine/exocrine_gland_phen	1.54965424
26	MP0001293_anophthalmia	1.54785769
27	MP0001529_abnormal_vocalization	1.52415356
28	MP0001905_abnormal_dopamine_level	1.51783879
29	MP0002277_abnormal_respiratory_mucosa	1.48685340
30	MP0005551_abnormal_eye_electrophysiolog	1.45403343
31	MP0008872_abnormal_physiological_respon	1.44705690
32	MP0004885_abnormal_endolymph	1.43206964
33	MP0002102_abnormal_ear_morphology	1.41490956
34	MP0003786_premature_aging	1.38624596
35	MP0003122_maternal_imprinting	1.34409112
36	MP0005253_abnormal_eye_physiology	1.29196530
37	MP0001968_abnormal_touch/_nociception	1.26977124
38	MP0002735_abnormal_chemical_nociception	1.21478387
39	MP0002138_abnormal_hepatobiliary_system	1.21297308
40	MP0005645_abnormal_hypothalamus_physiol	1.20036682
41	MP0008877_abnormal_DNA_methylation	1.18575485
42	MP0000372_irregular_coat_pigmentation	1.15677305
43	MP0002638_abnormal_pupillary_reflex	1.13460976
44	MP0003787_abnormal_imprinting	1.13261526
45	MP0005410_abnormal_fertilization	1.12276247
46	MP0005389_reproductive_system_phenotype	1.11228807
47	MP0002736_abnormal_nociception_after	1.10280339
48	MP0001485_abnormal_pinna_reflex	1.09741079
49	MP0001835_abnormal_antigen_presentation	1.06557593
50	MP0003136_yellow_coat_color	1.06087279
51	MP0002160_abnormal_reproductive_system	1.05978306
52	MP0001348_abnormal_lacrimal_gland	1.05709794
53	MP0009745_abnormal_behavioral_response	1.04535214
54	MP0003880_abnormal_central_pattern	1.02893161
55	MP0002876_abnormal_thyroid_physiology	1.02337628
56	MP0000685_abnormal_immune_system	1.02039456
57	MP0002938_white_spotting	1.01211193
58	MP0003938_abnormal_ear_development	1.00528552
59	MP0003121_genomic_imprinting	1.00063942
60	MP0000613_abnormal_salivary_gland	0.98561625
61	MP0004742_abnormal_vestibular_system	0.98412534
62	MP0001790_abnormal_immune_system	0.94859724
63	MP0005387_immune_system_phenotype	0.94859724
64	MP0005464_abnormal_platelet_physiology	0.93936278
65	MP0005075_abnormal_melanosome_morpholog	0.93408184
66	MP0002733_abnormal_thermal_nociception	0.92273153
67	MP0004484_altered_response_of	0.91236690
68	MP0002653_abnormal_ependyma_morphology	0.90681109
69	MP0002272_abnormal_nervous_system	0.90514321
70	MP0008789_abnormal_olfactory_epithelium	0.89904715
71	MP0001764_abnormal_homeostasis	0.88614046
72	MP0006035_abnormal_mitochondrial_morpho	0.86435966
73	MP0000230_abnormal_systemic_arterial	0.85871768
74	MP0005195_abnormal_posterior_eye	0.84129090
75	MP0001970_abnormal_pain_threshold	0.84019515
76	MP0002132_abnormal_respiratory_system	0.82783504
77	MP0010030_abnormal_orbit_morphology	0.82645172
78	MP0002210_abnormal_sex_determination	0.82338736
79	MP0005174_abnormal_tail_pigmentation	0.81969976
80	MP0002095_abnormal_skin_pigmentation	0.81848045
81	MP0001919_abnormal_reproductive_system	0.81771928
82	MP0001800_abnormal_humoral_immune	0.81400826
83	MP0002928_abnormal_bile_duct	0.79597538
84	MP0009697_abnormal_copulation	0.79402052
85	MP0002148_abnormal_hypersensitivity_rea	0.76876900
86	MP0003878_abnormal_ear_physiology	0.75737562
87	MP0005377_hearing/vestibular/ear_phenot	0.75737562
88	MP0000026_abnormal_inner_ear	0.75480558
89	MP0001929_abnormal_gametogenesis	0.75427657
90	MP0001879_abnormal_lymphatic_vessel	0.74932173
91	MP0003119_abnormal_digestive_system	0.73694802
92	MP0005391_vision/eye_phenotype	0.73193127
93	MP0009046_muscle_twitch	0.73132194
94	MP0002282_abnormal_trachea_morphology	0.71484953
95	MP0000653_abnormal_sex_gland	0.70470800
96	MP0001664_abnormal_digestion	0.69987851
97	MP0003698_abnormal_male_reproductive	0.69874198
98	MP0001984_abnormal_olfaction	0.69570522
99	MP0002557_abnormal_social/conspecific_i	0.67156196
100	MP0002693_abnormal_pancreas_physiology	0.66990881

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.75011624
2	Acute necrotizing encephalopathy (HP:0006965)	4.63991310
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.58077086
4	Mitochondrial inheritance (HP:0001427)	4.39551865
5	Abnormal number of erythroid precursors (HP:0012131)	4.19968159
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.16658717
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.11092616
8	Increased hepatocellular lipid droplets (HP:0006565)	4.08643919
9	Acute encephalopathy (HP:0006846)	3.94922780
10	Progressive macrocephaly (HP:0004481)	3.85869470
11	Renal Fanconi syndrome (HP:0001994)	3.79419614
12	Lipid accumulation in hepatocytes (HP:0006561)	3.77121169
13	3-Methylglutaconic aciduria (HP:0003535)	3.73587789
14	Increased CSF lactate (HP:0002490)	3.68947682
15	Cerebral edema (HP:0002181)	3.66008389
16	Hepatocellular necrosis (HP:0001404)	3.63876534
17	Macrocytic anemia (HP:0001972)	3.58458540
18	Pancreatic fibrosis (HP:0100732)	3.53482067
19	Pancreatic cysts (HP:0001737)	3.45688845
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.39316591
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.39316591
22	Hepatic necrosis (HP:0002605)	3.29738669
23	Abnormal rod and cone electroretinograms (HP:0008323)	3.27457404
24	Increased intramyocellular lipid droplets (HP:0012240)	3.23230132
25	Molar tooth sign on MRI (HP:0002419)	2.98197705
26	Abnormality of midbrain morphology (HP:0002418)	2.98197705
27	Pallor (HP:0000980)	2.97689324
28	Optic disc pallor (HP:0000543)	2.94220041
29	Abnormal ciliary motility (HP:0012262)	2.89320139
30	Methylmalonic acidemia (HP:0002912)	2.82270218
31	Absent/shortened dynein arms (HP:0200106)	2.74293446
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.74293446
33	Abnormal respiratory motile cilium morphology (HP:0005938)	2.73062757
34	Abnormal respiratory epithelium morphology (HP:0012253)	2.73062757
35	Increased muscle lipid content (HP:0009058)	2.70728528
36	Exertional dyspnea (HP:0002875)	2.70631989
37	True hermaphroditism (HP:0010459)	2.70081688
38	Abnormality of renal resorption (HP:0011038)	2.69929703
39	Congenital stationary night blindness (HP:0007642)	2.61938217
40	Lactic acidosis (HP:0003128)	2.61605331
41	Stenosis of the external auditory canal (HP:0000402)	2.58105064
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.56229444
43	Abnormality of the renal collecting system (HP:0004742)	2.49068574
44	Abnormal respiratory motile cilium physiology (HP:0012261)	2.43375941
45	Increased serum lactate (HP:0002151)	2.40949547
46	Chronic hepatic failure (HP:0100626)	2.40397784
47	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.38593351
48	Lethargy (HP:0001254)	2.31742659
49	Nephronophthisis (HP:0000090)	2.30306040
50	Respiratory failure (HP:0002878)	2.29060295
51	Ketosis (HP:0001946)	2.28302268
52	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.27429466
53	Short 1st metacarpal (HP:0010034)	2.27429466
54	Colon cancer (HP:0003003)	2.26309271
55	Medial flaring of the eyebrow (HP:0010747)	2.23693322
56	Absent thumb (HP:0009777)	2.22506317
57	Abnormal hemoglobin (HP:0011902)	2.20948909
58	Methylmalonic aciduria (HP:0012120)	2.17407774
59	Hyperglycinemia (HP:0002154)	2.15673404
60	Glycosuria (HP:0003076)	2.15372622
61	Abnormality of urine glucose concentration (HP:0011016)	2.15372622
62	Pendular nystagmus (HP:0012043)	2.14597796
63	Respiratory difficulties (HP:0002880)	2.13434913
64	Asplenia (HP:0001746)	2.09075346
65	Bile duct proliferation (HP:0001408)	2.06135527
66	Abnormal biliary tract physiology (HP:0012439)	2.06135527
67	Constricted visual fields (HP:0001133)	2.06087806
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.05503735
69	Decreased central vision (HP:0007663)	2.04186735
70	Elevated erythrocyte sedimentation rate (HP:0003565)	2.03917588
71	Cystic liver disease (HP:0006706)	2.01585657
72	Abnormality of the 1st metacarpal (HP:0010009)	2.01331350
73	Exercise intolerance (HP:0003546)	2.01092499
74	Abnormality of the renal cortex (HP:0011035)	1.98290180
75	Abnormality of the renal medulla (HP:0100957)	1.92690389
76	Hyperphosphaturia (HP:0003109)	1.92185137
77	Type II lissencephaly (HP:0007260)	1.91013810
78	Aplasia/hypoplasia of the uterus (HP:0008684)	1.90998541
79	Delayed CNS myelination (HP:0002188)	1.86734559
80	Septo-optic dysplasia (HP:0100842)	1.84774335
81	Leukodystrophy (HP:0002415)	1.84282365
82	Sclerocornea (HP:0000647)	1.84170411
83	Congenital hepatic fibrosis (HP:0002612)	1.81366380
84	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79516052
85	Depressed nasal ridge (HP:0000457)	1.76633512
86	Hypoplasia of the radius (HP:0002984)	1.75500606
87	Anencephaly (HP:0002323)	1.73678827
88	Hypoplasia of the uterus (HP:0000013)	1.72667954
89	Male pseudohermaphroditism (HP:0000037)	1.72103228
90	Chronic sinusitis (HP:0011109)	1.70709816
91	Abolished electroretinogram (ERG) (HP:0000550)	1.69879518
92	Abnormality of alanine metabolism (HP:0010916)	1.69065104
93	Hyperalaninemia (HP:0003348)	1.69065104
94	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.69065104
95	Attenuation of retinal blood vessels (HP:0007843)	1.67580860
96	Abnormal drinking behavior (HP:0030082)	1.67097699
97	Polydipsia (HP:0001959)	1.67097699
98	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.64793172
99	Short hallux (HP:0010109)	1.64265518
100	Triphalangeal thumb (HP:0001199)	1.63662644

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	8.73436780
2	PINK1	2.65684168
3	MAP2K7	2.52389672
4	TLK1	2.47750736
5	STK16	2.45858645
6	NME2	2.29285541
7	NUAK1	2.07735297
8	MAP4K2	2.01378363
9	FRK	1.91099521
10	VRK2	1.90697753
11	ADRBK2	1.89129664
12	TAOK3	1.81483595
13	GRK1	1.80719797
14	EIF2AK3	1.78128918
15	WNK4	1.77526029
16	MAP3K4	1.75211659
17	TRIM28	1.72057171
18	TXK	1.69456416
19	WNK3	1.59921249
20	ZAK	1.55589176
21	BMPR1B	1.51132189
22	VRK1	1.37726258
23	BUB1	1.31487388
24	CDK19	1.30445799
25	TEC	1.20703495
26	CDK8	1.20386967
27	DAPK2	1.20073120
28	DYRK2	1.19004168
29	IKBKB	1.17554803
30	GRK6	1.11390145
31	NEK2	1.10594534
32	RPS6KA4	1.09677388
33	MAP4K1	1.02769240
34	TIE1	0.99146376
35	MAPK13	0.98023441
36	TGFBR1	0.96685921
37	AKT3	0.93747177
38	BTK	0.88501257
39	MYLK	0.85562951
40	PRKCQ	0.83739314
41	TNK2	0.79545372
42	DAPK3	0.74955417
43	OBSCN	0.74246611
44	ITK	0.69168174
45	NME1	0.68575574
46	ADRBK1	0.67621909
47	TNIK	0.65252552
48	IKBKE	0.65010869
49	PASK	0.63651820
50	CDC7	0.63379726
51	KIT	0.62205130
52	RPS6KA5	0.59422390
53	FES	0.59197246
54	DYRK3	0.56414929
55	PIM1	0.54119512
56	SYK	0.53972343
57	PRKCG	0.51999793
58	GRK7	0.51164580
59	KDR	0.50731734
60	ILK	0.50654930
61	MAP3K10	0.50180300
62	AURKA	0.49252973
63	CSNK2A2	0.49210977
64	INSRR	0.49009260
65	EPHB2	0.48709669
66	CSNK1G3	0.48392936
67	SIK2	0.48269650
68	PAK3	0.47748834
69	CDK3	0.47530536
70	MARK3	0.47520861
71	MAP2K6	0.47413956
72	FGFR2	0.46700374
73	BRAF	0.46189640
74	GRK5	0.45744449
75	DAPK1	0.45663657
76	PIK3CG	0.45613907
77	MAPK15	0.43973735
78	AURKB	0.43251425
79	FLT3	0.43040498
80	PRKCD	0.42162594
81	BCR	0.42076685
82	SGK494	0.41779305
83	SGK223	0.41779305
84	PRKCE	0.41729690
85	MAP2K4	0.41695707
86	PLK2	0.39029116
87	CSNK2A1	0.38401605
88	PRKACA	0.38342688
89	CSNK1G2	0.36752874
90	LRRK2	0.36643940
91	CSNK1A1L	0.35764319
92	LYN	0.33804420
93	CAMK1	0.32629636
94	STK39	0.31963907
95	CSF1R	0.30917597
96	CSNK1A1	0.29908607
97	STK4	0.28471817
98	PAK1	0.26667809
99	MAPKAPK5	0.26165304
100	PLK4	0.26066826

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.47975977
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.28526645
3	Parkinsons disease_Homo sapiens_hsa05012	3.62627037
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.53247679
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.45059004
6	Huntingtons disease_Homo sapiens_hsa05016	2.36553351
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.32189702
8	Alzheimers disease_Homo sapiens_hsa05010	2.30498496
9	RNA polymerase_Homo sapiens_hsa03020	2.23765849
10	Sulfur relay system_Homo sapiens_hsa04122	2.16795617
11	Propanoate metabolism_Homo sapiens_hsa00640	2.04177616
12	Proteasome_Homo sapiens_hsa03050	1.92746907
13	Asthma_Homo sapiens_hsa05310	1.89212598
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.84525005
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.84051711
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.71423312
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.66460688
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.65277637
19	Allograft rejection_Homo sapiens_hsa05330	1.60894863
20	Protein export_Homo sapiens_hsa03060	1.54298396
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.52689694
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45829245
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45795693
24	Homologous recombination_Homo sapiens_hsa03440	1.31661108
25	Peroxisome_Homo sapiens_hsa04146	1.22240156
26	Type I diabetes mellitus_Homo sapiens_hsa04940	1.21990874
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18462474
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.17471126
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17073277
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.15653472
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15485651
32	RNA degradation_Homo sapiens_hsa03018	1.14682626
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.12252089
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.12025806
35	Phototransduction_Homo sapiens_hsa04744	1.11031714
36	Purine metabolism_Homo sapiens_hsa00230	1.05649956
37	Mismatch repair_Homo sapiens_hsa03430	1.04463660
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03395255
39	Primary immunodeficiency_Homo sapiens_hsa05340	1.01748489
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00729450
41	Base excision repair_Homo sapiens_hsa03410	0.98154964
42	Basal transcription factors_Homo sapiens_hsa03022	0.95814113
43	One carbon pool by folate_Homo sapiens_hsa00670	0.93292185
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92957067
45	Regulation of autophagy_Homo sapiens_hsa04140	0.90709625
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.86645513
47	Butanoate metabolism_Homo sapiens_hsa00650	0.86227406
48	Retinol metabolism_Homo sapiens_hsa00830	0.85221002
49	Olfactory transduction_Homo sapiens_hsa04740	0.85097866
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83780374
51	Spliceosome_Homo sapiens_hsa03040	0.83240474
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82175271
53	Folate biosynthesis_Homo sapiens_hsa00790	0.81689840
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79888666
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.79864068
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75769388
57	Caffeine metabolism_Homo sapiens_hsa00232	0.73617337
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73590684
59	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67506559
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66751503
61	Metabolic pathways_Homo sapiens_hsa01100	0.66486903
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.62571804
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62219772
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61074017
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59609055
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59320092
67	DNA replication_Homo sapiens_hsa03030	0.59184905
68	Serotonergic synapse_Homo sapiens_hsa04726	0.56688091
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.56468429
70	Rheumatoid arthritis_Homo sapiens_hsa05323	0.55430239
71	Taste transduction_Homo sapiens_hsa04742	0.52130901
72	Nicotine addiction_Homo sapiens_hsa05033	0.51433405
73	Antigen processing and presentation_Homo sapiens_hsa04612	0.50926785
74	Glutathione metabolism_Homo sapiens_hsa00480	0.49217527
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48968827
76	Fatty acid elongation_Homo sapiens_hsa00062	0.44443981
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.44008804
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43581972
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42286964
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42233118
81	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.39555260
82	Morphine addiction_Homo sapiens_hsa05032	0.39343603
83	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37136922
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36305411
85	RNA transport_Homo sapiens_hsa03013	0.35630947
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33738456
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33194338
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.32255551
89	Fatty acid degradation_Homo sapiens_hsa00071	0.31602963
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30594392
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29264329
92	Salivary secretion_Homo sapiens_hsa04970	0.27540743
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.27081280
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.26610389
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.26262542
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25033541
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.22041222
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.21186463
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.20226832
100	Alcoholism_Homo sapiens_hsa05034	0.20185315

RPS4XP16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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