ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.33820285
2	viral transcription (GO:0019083)	6.02674827
3	translational termination (GO:0006415)	5.73203365
4	ribosomal small subunit biogenesis (GO:0042274)	5.63075815
5	maturation of SSU-rRNA (GO:0030490)	5.52267974
6	ATP synthesis coupled proton transport (GO:0015986)	5.47048322
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.47048322
8	response to gravity (GO:0009629)	5.46720307
9	translational elongation (GO:0006414)	5.20013400
10	cornea development in camera-type eye (GO:0061303)	5.17007080
11	DNA deamination (GO:0045006)	4.81728547
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.80073154
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.75207437
14	cotranslational protein targeting to membrane (GO:0006613)	4.69083587
15	protein targeting to ER (GO:0045047)	4.67358808
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.47738897
17	protein localization to endoplasmic reticulum (GO:0070972)	4.45761170
18	cellular protein complex disassembly (GO:0043624)	4.17011310
19	viral life cycle (GO:0019058)	4.16385253
20	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.13002668
21	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.08243254
22	ribosomal large subunit biogenesis (GO:0042273)	4.04968805
23	translational initiation (GO:0006413)	3.96694529
24	GTP biosynthetic process (GO:0006183)	3.82042464
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.70401787
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.67423476
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.67423476
28	NADH dehydrogenase complex assembly (GO:0010257)	3.67423476
29	translation (GO:0006412)	3.64603205
30	cytidine deamination (GO:0009972)	3.64488438
31	cytidine metabolic process (GO:0046087)	3.64488438
32	cytidine catabolic process (GO:0006216)	3.64488438
33	skeletal muscle tissue regeneration (GO:0043403)	3.63011464
34	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.61181315
35	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.59903325
36	protein complex biogenesis (GO:0070271)	3.59470512
37	negative regulation of muscle hypertrophy (GO:0014741)	3.58680817
38	behavioral response to nicotine (GO:0035095)	3.58603612
39	pyrimidine nucleotide catabolic process (GO:0006244)	3.58477490
40	electron transport chain (GO:0022900)	3.56030393
41	protein neddylation (GO:0045116)	3.55859160
42	respiratory electron transport chain (GO:0022904)	3.53682069
43	ATP biosynthetic process (GO:0006754)	3.52912018
44	protein complex disassembly (GO:0043241)	3.42121081
45	kynurenine metabolic process (GO:0070189)	3.41483886
46	regulation of skeletal muscle contraction (GO:0014819)	3.38586917
47	base-excision repair, AP site formation (GO:0006285)	3.35787324
48	macromolecular complex disassembly (GO:0032984)	3.31779221
49	purine nucleotide salvage (GO:0032261)	3.28691367
50	nephron tubule formation (GO:0072079)	3.28184905
51	deoxyribonucleotide catabolic process (GO:0009264)	3.24101137
52	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.20267201
53	UTP biosynthetic process (GO:0006228)	3.17803347
54	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.12714350
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.12265112
56	ribonucleoprotein complex biogenesis (GO:0022613)	3.10541345
57	deoxyribose phosphate catabolic process (GO:0046386)	3.10112244
58	UTP metabolic process (GO:0046051)	3.09910862
59	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.09779786
60	cellular component biogenesis (GO:0044085)	3.07950404
61	mitochondrial respiratory chain complex assembly (GO:0033108)	3.06755521
62	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.05956958
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.04411137
64	protein targeting to membrane (GO:0006612)	3.01908637
65	indole-containing compound catabolic process (GO:0042436)	2.97960426
66	indolalkylamine catabolic process (GO:0046218)	2.97960426
67	tryptophan catabolic process (GO:0006569)	2.97960426
68	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.95543716
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.95543716
70	mannosylation (GO:0097502)	2.93546954
71	cellular ketone body metabolic process (GO:0046950)	2.92294039
72	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.91183910
73	termination of RNA polymerase III transcription (GO:0006386)	2.91183910
74	protein-cofactor linkage (GO:0018065)	2.91096241
75	purine deoxyribonucleotide catabolic process (GO:0009155)	2.88404739
76	pseudouridine synthesis (GO:0001522)	2.87809046
77	guanosine-containing compound biosynthetic process (GO:1901070)	2.87469219
78	respiratory chain complex IV assembly (GO:0008535)	2.87378351
79	mRNA catabolic process (GO:0006402)	2.85750432
80	preassembly of GPI anchor in ER membrane (GO:0016254)	2.85061936
81	rRNA processing (GO:0006364)	2.84003866
82	hydrogen ion transmembrane transport (GO:1902600)	2.79436257
83	rRNA metabolic process (GO:0016072)	2.78972069
84	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.78058234
85	skeletal muscle adaptation (GO:0043501)	2.77934492
86	actin-myosin filament sliding (GO:0033275)	2.76576880
87	muscle filament sliding (GO:0030049)	2.76576880
88	cytochrome complex assembly (GO:0017004)	2.74720785
89	positive regulation of odontogenesis (GO:0042482)	2.74526700
90	striated muscle atrophy (GO:0014891)	2.74351668
91	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.72594016
92	oxidative phosphorylation (GO:0006119)	2.68848825
93	axoneme assembly (GO:0035082)	2.68446205
94	nucleoside triphosphate biosynthetic process (GO:0009142)	2.65590220
95	water-soluble vitamin biosynthetic process (GO:0042364)	2.63739940
96	platelet dense granule organization (GO:0060155)	2.62495147
97	indolalkylamine metabolic process (GO:0006586)	2.59370303
98	GPI anchor metabolic process (GO:0006505)	2.58562763
99	CTP metabolic process (GO:0046036)	2.58239847
100	CTP biosynthetic process (GO:0006241)	2.58239847

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.83774984
2	VDR_22108803_ChIP-Seq_LS180_Human	4.55789998
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.06875130
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.96387463
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51754082
6	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.50728163
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.48429901
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.47463980
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.42339177
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.30944130
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.24134225
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.21312119
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.11277876
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02545061
15	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.92698832
16	FUS_26573619_Chip-Seq_HEK293_Human	1.92336967
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.83492219
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.83100571
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.75578350
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.75103089
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.73452983
22	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.71330503
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.67414942
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.66027442
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.62421495
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62290240
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.56995908
28	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53574032
29	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53574032
30	TAF2_19829295_ChIP-Seq_ESCs_Human	1.53108470
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52663295
32	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.50471416
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48064923
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.43974582
35	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.43737329
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41622671
37	AR_21572438_ChIP-Seq_LNCaP_Human	1.38917250
38	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.36963237
39	MYC_19829295_ChIP-Seq_ESCs_Human	1.36626467
40	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.35171603
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35037612
42	AR_20517297_ChIP-Seq_VCAP_Human	1.33288437
43	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.31834302
44	EWS_26573619_Chip-Seq_HEK293_Human	1.31230030
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31215265
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31107928
47	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30601062
48	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.29959252
49	ERA_21632823_ChIP-Seq_H3396_Human	1.29153338
50	NCOR_22424771_ChIP-Seq_293T_Human	1.28670302
51	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.28276688
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28001343
53	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.27667840
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27452253
55	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.25915677
56	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.24415597
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23393110
58	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.23271658
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23208518
60	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.20892185
61	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19924933
62	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19425435
63	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.17771645
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17282885
65	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.16566963
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16142283
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15745661
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15571300
69	BCL6_27268052_Chip-Seq_Bcells_Human	1.14315562
70	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.14179826
71	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13324772
72	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.10905124
73	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08520622
74	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.07861910
75	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06552937
76	ERG_20517297_ChIP-Seq_VCAP_Human	1.06007542
77	HTT_18923047_ChIP-ChIP_STHdh_Human	1.05816387
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.05421913
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05421913
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.05153857
81	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02947024
82	E2F1_20622854_ChIP-Seq_HELA_Human	1.02904429
83	STAT1_20625510_ChIP-Seq_HELA_Human	1.01114378
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00712811
85	MYB_26560356_Chip-Seq_TH2_Human	1.00261919
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00119004
87	ER_23166858_ChIP-Seq_MCF-7_Human	0.99695840
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98374315
89	ELK1_19687146_ChIP-ChIP_HELA_Human	0.97874682
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97236818
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96382220
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96382220
93	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.95302326
94	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.95094823
95	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.94154546
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93651250
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92942060
98	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92545812
99	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92309534
100	P300_27268052_Chip-Seq_Bcells_Human	0.92290554

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.03244008
2	MP0004145_abnormal_muscle_electrophysio	3.00984625
3	MP0008877_abnormal_DNA_methylation	2.91200241
4	MP0003787_abnormal_imprinting	2.69544588
5	MP0005646_abnormal_pituitary_gland	2.69530984
6	MP0001968_abnormal_touch/_nociception	2.69237800
7	MP0003806_abnormal_nucleotide_metabolis	2.68817263
8	MP0005671_abnormal_response_to	2.52697968
9	MP0001835_abnormal_antigen_presentation	2.48936768
10	MP0006292_abnormal_olfactory_placode	2.31812545
11	MP0002736_abnormal_nociception_after	2.21243365
12	MP0006072_abnormal_retinal_apoptosis	2.19652454
13	MP0004885_abnormal_endolymph	2.07832103
14	MP0004142_abnormal_muscle_tone	2.07521818
15	MP0000372_irregular_coat_pigmentation	2.04611197
16	MP0008995_early_reproductive_senescence	1.96966827
17	MP0003646_muscle_fatigue	1.95506295
18	MP0008875_abnormal_xenobiotic_pharmacok	1.87418634
19	MP0003786_premature_aging	1.86524834
20	MP0005083_abnormal_biliary_tract	1.83753075
21	MP0008872_abnormal_physiological_respon	1.67787140
22	MP0005551_abnormal_eye_electrophysiolog	1.63884049
23	MP0005084_abnormal_gallbladder_morpholo	1.62704020
24	MP0002837_dystrophic_cardiac_calcinosis	1.59294708
25	MP0002735_abnormal_chemical_nociception	1.58932211
26	MP0002102_abnormal_ear_morphology	1.53763729
27	MP0006276_abnormal_autonomic_nervous	1.49002141
28	MP0001986_abnormal_taste_sensitivity	1.44271428
29	MP0002638_abnormal_pupillary_reflex	1.38374648
30	MP0009333_abnormal_splenocyte_physiolog	1.32392106
31	MP0002876_abnormal_thyroid_physiology	1.31900747
32	MP0005075_abnormal_melanosome_morpholog	1.29914459
33	MP0002733_abnormal_thermal_nociception	1.27998334
34	MP0001905_abnormal_dopamine_level	1.27111754
35	MP0002272_abnormal_nervous_system	1.23360381
36	MP0001440_abnormal_grooming_behavior	1.21058542
37	MP0004036_abnormal_muscle_relaxation	1.17644355
38	MP0006036_abnormal_mitochondrial_physio	1.16893936
39	MP0005389_reproductive_system_phenotype	1.15853040
40	MP0003959_abnormal_lean_body	1.14269415
41	MP0001970_abnormal_pain_threshold	1.14042038
42	MP0002160_abnormal_reproductive_system	1.12699018
43	MP0002163_abnormal_gland_morphology	1.12607547
44	MP0000685_abnormal_immune_system	1.12205628
45	MP0005377_hearing/vestibular/ear_phenot	1.11916886
46	MP0003878_abnormal_ear_physiology	1.11916886
47	MP0005253_abnormal_eye_physiology	1.11060577
48	MP0001919_abnormal_reproductive_system	1.09823947
49	MP0000631_abnormal_neuroendocrine_gland	1.09308960
50	MP0002138_abnormal_hepatobiliary_system	1.07148710
51	MP0003121_genomic_imprinting	1.06199561
52	MP0002723_abnormal_immune_serum	1.05550049
53	MP0009745_abnormal_behavioral_response	1.05209496
54	MP0001873_stomach_inflammation	1.04862144
55	MP0004043_abnormal_pH_regulation	1.04580112
56	MP0005423_abnormal_somatic_nervous	1.02761625
57	MP0001661_extended_life_span	1.01975626
58	MP0001800_abnormal_humoral_immune	1.01136230
59	MP0001764_abnormal_homeostasis	1.00671430
60	MP0002148_abnormal_hypersensitivity_rea	1.00345984
61	MP0000049_abnormal_middle_ear	0.99191125
62	MP0003567_abnormal_fetal_cardiomyocyte	0.98137168
63	MP0002095_abnormal_skin_pigmentation	0.97615145
64	MP0001348_abnormal_lacrimal_gland	0.95238197
65	MP0009785_altered_susceptibility_to	0.94011137
66	MP0001188_hyperpigmentation	0.90976490
67	MP0001529_abnormal_vocalization	0.90492762
68	MP0002184_abnormal_innervation	0.89459532
69	MP0000678_abnormal_parathyroid_gland	0.88128519
70	MP0004147_increased_porphyrin_level	0.88041774
71	MP0002269_muscular_atrophy	0.87776685
72	MP0005000_abnormal_immune_tolerance	0.84984453
73	MP0002420_abnormal_adaptive_immunity	0.84863868
74	MP0004742_abnormal_vestibular_system	0.84514707
75	MP0005645_abnormal_hypothalamus_physiol	0.84397189
76	MP0001819_abnormal_immune_cell	0.84171427
77	MP0002132_abnormal_respiratory_system	0.83220040
78	MP0008789_abnormal_olfactory_epithelium	0.80149007
79	MP0000747_muscle_weakness	0.79947250
80	MP0003252_abnormal_bile_duct	0.79828445
81	MP0003638_abnormal_response/metabolism_	0.79612477
82	MP0002106_abnormal_muscle_physiology	0.79359105
83	MP0002234_abnormal_pharynx_morphology	0.78934773
84	MP0004484_altered_response_of	0.78401321
85	MP0008775_abnormal_heart_ventricle	0.78152694
86	MP0002166_altered_tumor_susceptibility	0.77679283
87	MP0009764_decreased_sensitivity_to	0.71844359
88	MP0003195_calcinosis	0.71579963
89	MP0002734_abnormal_mechanical_nocicepti	0.71478133
90	MP0002006_tumorigenesis	0.71428193
91	MP0009250_abnormal_appendicular_skeleto	0.71085235
92	MP0002277_abnormal_respiratory_mucosa	0.68780227
93	MP0003879_abnormal_hair_cell	0.68700756
94	MP0002752_abnormal_somatic_nervous	0.68297851
95	MP0003880_abnormal_central_pattern	0.67746908
96	MP0004924_abnormal_behavior	0.66841756
97	MP0005386_behavior/neurological_phenoty	0.66841756
98	MP0000383_abnormal_hair_follicle	0.66102744
99	MP0002210_abnormal_sex_determination	0.65646206
100	MP0003123_paternal_imprinting	0.64656146

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.62464101
2	Acute necrotizing encephalopathy (HP:0006965)	4.62104520
3	Reticulocytopenia (HP:0001896)	4.51382590
4	Mitochondrial inheritance (HP:0001427)	4.06349999
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.00233669
6	Progressive macrocephaly (HP:0004481)	3.91641828
7	Acute encephalopathy (HP:0006846)	3.90335217
8	Abnormality of alanine metabolism (HP:0010916)	3.87832399
9	Hyperalaninemia (HP:0003348)	3.87832399
10	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.87832399
11	Increased CSF lactate (HP:0002490)	3.77824332
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.71910197
13	Macrocytic anemia (HP:0001972)	3.43095770
14	Congenital stationary night blindness (HP:0007642)	3.36352041
15	Hepatocellular necrosis (HP:0001404)	3.20694282
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.19333438
17	Palpebral edema (HP:0100540)	3.12777888
18	Cerebral edema (HP:0002181)	3.10972213
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.02771784
20	Pancreatic cysts (HP:0001737)	2.97986219
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.97046295
22	Hepatic necrosis (HP:0002605)	2.93086401
23	Constricted visual fields (HP:0001133)	2.92553511
24	Increased hepatocellular lipid droplets (HP:0006565)	2.90417418
25	Abnormality of cells of the erythroid lineage (HP:0012130)	2.89464679
26	Pallor (HP:0000980)	2.89381714
27	Optic disc pallor (HP:0000543)	2.88714200
28	Lipid accumulation in hepatocytes (HP:0006561)	2.79736406
29	Type 2 muscle fiber atrophy (HP:0003554)	2.78917714
30	Distal arthrogryposis (HP:0005684)	2.73990054
31	Increased serum lactate (HP:0002151)	2.72755677
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.69367308
33	Pancreatic fibrosis (HP:0100732)	2.68815985
34	Lactic acidosis (HP:0003128)	2.60917138
35	Abnormal hemoglobin (HP:0011902)	2.58422743
36	Decreased central vision (HP:0007663)	2.52867906
37	Methylmalonic acidemia (HP:0002912)	2.52843746
38	Abnormality of midbrain morphology (HP:0002418)	2.50094872
39	Molar tooth sign on MRI (HP:0002419)	2.50094872
40	Renal Fanconi syndrome (HP:0001994)	2.48466786
41	Hyperglycinemia (HP:0002154)	2.45901576
42	Absent phalangeal crease (HP:0006109)	2.45398593
43	Muscle fiber atrophy (HP:0100295)	2.45053687
44	Stomatitis (HP:0010280)	2.43101796
45	Pendular nystagmus (HP:0012043)	2.41578983
46	Exertional dyspnea (HP:0002875)	2.39382869
47	IgG deficiency (HP:0004315)	2.38965414
48	Abolished electroretinogram (ERG) (HP:0000550)	2.38868117
49	Abnormality of B cell number (HP:0010975)	2.37022409
50	Abnormal number of erythroid precursors (HP:0012131)	2.34779754
51	True hermaphroditism (HP:0010459)	2.34471926
52	Stenosis of the external auditory canal (HP:0000402)	2.33966831
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.28969549
54	Increased intramyocellular lipid droplets (HP:0012240)	2.25568241
55	Calcaneovalgus deformity (HP:0001848)	2.21830445
56	Congenital, generalized hypertrichosis (HP:0004540)	2.17375274
57	Methylmalonic aciduria (HP:0012120)	2.15676977
58	Attenuation of retinal blood vessels (HP:0007843)	2.15384190
59	Lethargy (HP:0001254)	2.12990766
60	Exercise intolerance (HP:0003546)	2.06151456
61	Decreased circulating renin level (HP:0003351)	2.05882520
62	Nephronophthisis (HP:0000090)	2.04493795
63	Ketosis (HP:0001946)	2.02889570
64	Abnormality of urine glucose concentration (HP:0011016)	2.01013113
65	Glycosuria (HP:0003076)	2.01013113
66	Delayed CNS myelination (HP:0002188)	2.00927958
67	Respiratory failure (HP:0002878)	2.00078874
68	Abnormality of serum amino acid levels (HP:0003112)	1.98196062
69	Colon cancer (HP:0003003)	1.97678907
70	Deformed tarsal bones (HP:0008119)	1.97466885
71	Severe combined immunodeficiency (HP:0004430)	1.96999139
72	Type I transferrin isoform profile (HP:0003642)	1.96926262
73	B lymphocytopenia (HP:0010976)	1.95220335
74	Abnormal drinking behavior (HP:0030082)	1.94082434
75	Polydipsia (HP:0001959)	1.94082434
76	Increased muscle lipid content (HP:0009058)	1.92710080
77	Hypoplasia of the uterus (HP:0000013)	1.90000790
78	Sclerocornea (HP:0000647)	1.89477295
79	Respiratory difficulties (HP:0002880)	1.89370061
80	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.87636984
81	Absent/shortened dynein arms (HP:0200106)	1.87636984
82	Abnormal finger flexion creases (HP:0006143)	1.87568962
83	Abnormality of the prostate (HP:0008775)	1.86960245
84	Increased IgM level (HP:0003496)	1.86771147
85	Dicarboxylic aciduria (HP:0003215)	1.84797904
86	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.84797904
87	Periorbital edema (HP:0100539)	1.82889921
88	Testicular atrophy (HP:0000029)	1.80293967
89	Metaphyseal dysplasia (HP:0100255)	1.80261412
90	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.80209876
91	Aplastic anemia (HP:0001915)	1.80078609
92	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79288821
93	Autoimmune thrombocytopenia (HP:0001973)	1.78539808
94	Thyroiditis (HP:0100646)	1.78517896
95	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.76753740
96	Leukodystrophy (HP:0002415)	1.72949258
97	Facial edema (HP:0000282)	1.71581137
98	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.69599652
99	Abnormality of the renal medulla (HP:0100957)	1.67834127
100	Polyuria (HP:0000103)	1.67693161

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.40019746
2	TLK1	3.21736065
3	BCKDK	3.17821291
4	TAOK3	3.13283876
5	STK16	3.02456591
6	PDK2	2.79079412
7	CDK19	2.52199079
8	NUAK1	2.39349258
9	VRK2	2.36228802
10	TXK	2.14097526
11	ADRBK2	2.13099270
12	WNK4	2.10897908
13	ZAK	2.07959747
14	PINK1	1.95389093
15	TIE1	1.95369278
16	TAF1	1.94837879
17	MAP3K9	1.90271946
18	MAP4K2	1.87904943
19	GRK1	1.84521969
20	PHKG2	1.79023513
21	PHKG1	1.79023513
22	FRK	1.76926957
23	DYRK2	1.48464686
24	OBSCN	1.47003258
25	PIK3CG	1.40795462
26	TEC	1.32588005
27	CSNK1G1	1.32281365
28	JAK3	1.22012644
29	ITK	1.14320186
30	CSNK1G3	1.14290684
31	GRK6	1.13895545
32	SCYL2	1.11807327
33	KDR	1.10249674
34	OXSR1	1.07343724
35	CAMKK2	1.03832948
36	MUSK	1.02968917
37	PIK3CA	1.01923089
38	VRK1	1.00016196
39	CSNK1A1L	0.96993400
40	IKBKB	0.94703212
41	MAPK13	0.92728662
42	CSNK1G2	0.91779497
43	EIF2AK3	0.91172272
44	MAP3K12	0.90550044
45	IKBKE	0.86586238
46	INSRR	0.86579923
47	WNK3	0.83149566
48	MAP4K1	0.82548333
49	FES	0.78919346
50	ABL2	0.78093352
51	BTK	0.76498058
52	KIT	0.76480208
53	TYRO3	0.75097143
54	PRKCQ	0.74912521
55	AURKA	0.73714450
56	TNK2	0.72903379
57	DAPK1	0.70257495
58	RPS6KA5	0.69937729
59	MAPK7	0.69691931
60	STK39	0.67910075
61	CAMK1	0.64674154
62	GRK5	0.63714290
63	SYK	0.60968599
64	ADRBK1	0.58117686
65	LCK	0.57962716
66	SGK223	0.53490408
67	SGK494	0.53490408
68	CHEK2	0.52390258
69	MAPKAPK5	0.52063324
70	MAP3K11	0.51801036
71	MARK1	0.49844465
72	BMPR1B	0.49598306
73	HIPK2	0.48909349
74	MAP2K6	0.47872667
75	TRPM7	0.45988527
76	CSNK1A1	0.43387565
77	CDK3	0.42921328
78	SGK2	0.42476622
79	EIF2AK2	0.40064418
80	PRKACA	0.39548511
81	TESK2	0.38924122
82	MYLK	0.38248202
83	MAP2K7	0.37600433
84	PRKCA	0.36565951
85	LYN	0.36296784
86	CSNK2A2	0.35490693
87	PRKCE	0.34640617
88	PRKCG	0.34452784
89	PIM1	0.33947916
90	PLK4	0.33718814
91	RPS6KA6	0.32865682
92	CSNK2A1	0.32760946
93	DAPK3	0.31351650
94	RPS6KA4	0.28852876
95	PRKCD	0.28802627
96	CSF1R	0.28468701
97	CHUK	0.28331008
98	PAK1	0.27847883
99	NLK	0.27518440
100	CAMKK1	0.27358281

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.50900897
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.68208491
3	Asthma_Homo sapiens_hsa05310	3.35077801
4	Parkinsons disease_Homo sapiens_hsa05012	2.86038433
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.57515840
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.53198714
7	Allograft rejection_Homo sapiens_hsa05330	2.52746255
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.33907616
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.29390901
10	Proteasome_Homo sapiens_hsa03050	2.13721163
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10169529
12	RNA polymerase_Homo sapiens_hsa03020	2.09537758
13	Alzheimers disease_Homo sapiens_hsa05010	2.08243805
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96876998
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.89208580
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.85923467
17	Caffeine metabolism_Homo sapiens_hsa00232	1.84178389
18	Huntingtons disease_Homo sapiens_hsa05016	1.84049534
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.83671518
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71191738
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.61204418
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59646225
23	RNA degradation_Homo sapiens_hsa03018	1.45692045
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.35962863
25	Phototransduction_Homo sapiens_hsa04744	1.34325788
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.30693890
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.22820739
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17150356
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.17022934
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.16769478
31	Rheumatoid arthritis_Homo sapiens_hsa05323	1.15684758
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14784988
33	One carbon pool by folate_Homo sapiens_hsa00670	1.13735914
34	Regulation of autophagy_Homo sapiens_hsa04140	1.13694777
35	Sulfur relay system_Homo sapiens_hsa04122	1.10840165
36	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.09164570
37	Homologous recombination_Homo sapiens_hsa03440	1.07595162
38	Purine metabolism_Homo sapiens_hsa00230	1.05734851
39	Ether lipid metabolism_Homo sapiens_hsa00565	0.99917894
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97734358
41	Protein export_Homo sapiens_hsa03060	0.96633992
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.96567598
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.90920638
44	Nicotine addiction_Homo sapiens_hsa05033	0.87401104
45	Peroxisome_Homo sapiens_hsa04146	0.84870634
46	Basal transcription factors_Homo sapiens_hsa03022	0.84351647
47	DNA replication_Homo sapiens_hsa03030	0.81783507
48	Olfactory transduction_Homo sapiens_hsa04740	0.79141797
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78810207
50	Spliceosome_Homo sapiens_hsa03040	0.77914874
51	Viral myocarditis_Homo sapiens_hsa05416	0.77903161
52	RNA transport_Homo sapiens_hsa03013	0.75169827
53	Propanoate metabolism_Homo sapiens_hsa00640	0.74435403
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73487412
55	Morphine addiction_Homo sapiens_hsa05032	0.72698242
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70547532
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70303815
58	Retinol metabolism_Homo sapiens_hsa00830	0.67235498
59	Nucleotide excision repair_Homo sapiens_hsa03420	0.63583595
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62738951
61	Taste transduction_Homo sapiens_hsa04742	0.61886714
62	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.61583920
63	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60346392
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60087989
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58854856
66	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58489599
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58468329
68	Basal cell carcinoma_Homo sapiens_hsa05217	0.57555011
69	Metabolic pathways_Homo sapiens_hsa01100	0.55603237
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55358039
71	Salivary secretion_Homo sapiens_hsa04970	0.51132905
72	Serotonergic synapse_Homo sapiens_hsa04726	0.49596853
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48414464
74	Butanoate metabolism_Homo sapiens_hsa00650	0.47707150
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47231043
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.47002933
77	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.46538020
78	Circadian entrainment_Homo sapiens_hsa04713	0.45607864
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44876318
80	Mismatch repair_Homo sapiens_hsa03430	0.43704099
81	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43682389
82	Base excision repair_Homo sapiens_hsa03410	0.43336221
83	GABAergic synapse_Homo sapiens_hsa04727	0.42033333
84	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38724237
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36588657
86	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.35317147
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.35100666
88	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.34896148
89	Sulfur metabolism_Homo sapiens_hsa00920	0.33305766
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33013125
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32693829
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29743998
93	Leishmaniasis_Homo sapiens_hsa05140	0.29546142
94	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.28506703
95	Cholinergic synapse_Homo sapiens_hsa04725	0.27381070
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.26779546
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.24980987
98	Insulin secretion_Homo sapiens_hsa04911	0.23360480
99	Glutathione metabolism_Homo sapiens_hsa00480	0.20792156
100	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.20139593

RPS4XP17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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