ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.38541291
2	ATP synthesis coupled proton transport (GO:0015986)	6.01719924
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.01719924
4	DNA deamination (GO:0045006)	5.13676918
5	kynurenine metabolic process (GO:0070189)	5.07471986
6	indole-containing compound catabolic process (GO:0042436)	4.76887883
7	indolalkylamine catabolic process (GO:0046218)	4.76887883
8	tryptophan catabolic process (GO:0006569)	4.76887883
9	tryptophan metabolic process (GO:0006568)	4.59794471
10	preassembly of GPI anchor in ER membrane (GO:0016254)	4.53201430
11	water-soluble vitamin biosynthetic process (GO:0042364)	4.32760108
12	protein complex biogenesis (GO:0070271)	4.31060586
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.29513835
14	positive regulation of prostaglandin secretion (GO:0032308)	4.21882516
15	respiratory electron transport chain (GO:0022904)	3.97846364
16	electron transport chain (GO:0022900)	3.96705854
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.95120180
18	NADH dehydrogenase complex assembly (GO:0010257)	3.95120180
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.95120180
20	mannosylation (GO:0097502)	3.94441746
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.90545754
22	piRNA metabolic process (GO:0034587)	3.86412670
23	ribosomal small subunit assembly (GO:0000028)	3.83870964
24	protein neddylation (GO:0045116)	3.78966786
25	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.73593002
26	positive regulation of protein homodimerization activity (GO:0090073)	3.72663653
27	indolalkylamine metabolic process (GO:0006586)	3.71570424
28	respiratory chain complex IV assembly (GO:0008535)	3.71211766
29	chaperone-mediated protein transport (GO:0072321)	3.69434453
30	response to pheromone (GO:0019236)	3.69287925
31	regulation of prostaglandin secretion (GO:0032306)	3.59513967
32	cytochrome complex assembly (GO:0017004)	3.52267612
33	ribosomal large subunit biogenesis (GO:0042273)	3.38480058
34	ATP biosynthetic process (GO:0006754)	3.37024481
35	response to xenobiotic stimulus (GO:0009410)	3.30107428
36	viral transcription (GO:0019083)	3.27255290
37	regulation of hypersensitivity (GO:0002883)	3.20754555
38	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.20550581
39	rRNA modification (GO:0000154)	3.19104736
40	oxidative phosphorylation (GO:0006119)	3.15986135
41	positive regulation of fatty acid transport (GO:2000193)	3.15304439
42	cytidine metabolic process (GO:0046087)	3.14680026
43	cytidine catabolic process (GO:0006216)	3.14680026
44	cytidine deamination (GO:0009972)	3.14680026
45	hydrogen ion transmembrane transport (GO:1902600)	3.13061063
46	GPI anchor biosynthetic process (GO:0006506)	3.12586425
47	pseudouridine synthesis (GO:0001522)	3.11422390
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.11359020
49	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.09895538
50	translational termination (GO:0006415)	3.09598774
51	GPI anchor metabolic process (GO:0006505)	3.04307021
52	positive regulation of icosanoid secretion (GO:0032305)	3.03961223
53	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.02380827
54	negative regulation of mast cell activation (GO:0033004)	2.98715814
55	maturation of SSU-rRNA (GO:0030490)	2.98541742
56	protein-cofactor linkage (GO:0018065)	2.98310601
57	proton transport (GO:0015992)	2.96560760
58	translational elongation (GO:0006414)	2.94846133
59	hydrogen transport (GO:0006818)	2.94433923
60	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.94174497
61	sleep (GO:0030431)	2.92915505
62	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.92513574
63	protein targeting to ER (GO:0045047)	2.90588904
64	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.90162977
65	amino acid salvage (GO:0043102)	2.89301052
66	L-methionine salvage (GO:0071267)	2.89301052
67	L-methionine biosynthetic process (GO:0071265)	2.89301052
68	amine catabolic process (GO:0009310)	2.88162617
69	cellular biogenic amine catabolic process (GO:0042402)	2.88162617
70	DNA catabolic process, exonucleolytic (GO:0000738)	2.86211059
71	parturition (GO:0007567)	2.85522813
72	cotranslational protein targeting to membrane (GO:0006613)	2.84226441
73	L-fucose catabolic process (GO:0042355)	2.80337472
74	fucose catabolic process (GO:0019317)	2.80337472
75	L-fucose metabolic process (GO:0042354)	2.80337472
76	protein localization to endoplasmic reticulum (GO:0070972)	2.79866660
77	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.78074655
78	S-adenosylmethionine metabolic process (GO:0046500)	2.76721532
79	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74958171
80	aromatic amino acid family catabolic process (GO:0009074)	2.74338875
81	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.71922445
82	cellular response to exogenous dsRNA (GO:0071360)	2.69898285
83	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.69756571
84	regulation of cilium movement (GO:0003352)	2.69338185
85	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.68276100
86	immunoglobulin mediated immune response (GO:0016064)	2.67414715
87	lysine metabolic process (GO:0006553)	2.66900519
88	lysine catabolic process (GO:0006554)	2.66900519
89	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.63856299
90	benzene-containing compound metabolic process (GO:0042537)	2.63840007
91	DNA methylation involved in gamete generation (GO:0043046)	2.63836941
92	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.63773869
93	cellular response to ATP (GO:0071318)	2.58770532
94	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.58651353
95	termination of RNA polymerase III transcription (GO:0006386)	2.58651353
96	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.55810334
97	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.55810334
98	regulation of germinal center formation (GO:0002634)	2.53799752
99	aldehyde catabolic process (GO:0046185)	2.53088434
100	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.51924276

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.08610976
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.96582945
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.54028454
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.49835713
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.04084957
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.98668164
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.96775845
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86497376
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.74496764
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.66977397
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.46391436
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.41538567
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.31425091
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.19169938
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.15197312
16	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.12472129
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.01944831
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00775374
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98367659
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.97825263
21	VDR_22108803_ChIP-Seq_LS180_Human	1.86994565
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75975653
23	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.74083574
24	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.71752114
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.69480559
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.68446874
27	GATA3_26560356_Chip-Seq_TH2_Human	1.66608013
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.62950722
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62789452
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55425206
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.52593681
32	AR_20517297_ChIP-Seq_VCAP_Human	1.52254676
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.49244142
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.49244142
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.47119712
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45394224
37	EWS_26573619_Chip-Seq_HEK293_Human	1.45038161
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44970584
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43248465
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.43216749
41	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.42802336
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.42523395
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.40339581
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.37801112
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33646268
46	FUS_26573619_Chip-Seq_HEK293_Human	1.33499473
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.32809163
48	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.31551915
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31496260
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31496260
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.30119306
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28464165
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.27602675
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27028347
55	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.26519965
56	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.23050305
57	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.22956661
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22932817
59	GBX2_23144817_ChIP-Seq_PC3_Human	1.22082335
60	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.21839612
61	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.21631019
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21613486
63	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.19724805
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17829550
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17237499
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15727312
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15388900
68	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13480508
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12134306
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09277422
71	NCOR_22424771_ChIP-Seq_293T_Human	1.09041168
72	ERG_20517297_ChIP-Seq_VCAP_Human	1.08418772
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07708468
74	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.06567276
75	STAT1_20625510_ChIP-Seq_HELA_Human	1.06454856
76	CIITA_25753668_ChIP-Seq_RAJI_Human	1.06401649
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06267257
78	P300_19829295_ChIP-Seq_ESCs_Human	1.05733689
79	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05045289
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.04082212
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.03375319
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01939270
83	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.01868889
84	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.01677148
85	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01506490
86	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01128350
87	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98997515
88	ERA_21632823_ChIP-Seq_H3396_Human	0.98004998
89	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.95402195
90	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.95052063
91	TTF2_22483619_ChIP-Seq_HELA_Human	0.94964948
92	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.94609345
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94048101
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93628005
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93304590
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.92640044
97	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92640044
98	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.91319063
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90546818
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.90409570

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	4.09353020
2	MP0004147_increased_porphyrin_level	3.13152777
3	MP0006072_abnormal_retinal_apoptosis	3.02625992
4	MP0001835_abnormal_antigen_presentation	2.81367938
5	MP0003011_delayed_dark_adaptation	2.53133707
6	MP0001986_abnormal_taste_sensitivity	2.49633312
7	MP0008877_abnormal_DNA_methylation	2.47865264
8	MP0000685_abnormal_immune_system	2.45508585
9	MP0005646_abnormal_pituitary_gland	2.44077010
10	MP0003646_muscle_fatigue	2.30469565
11	MP0005671_abnormal_response_to	2.14524003
12	MP0002876_abnormal_thyroid_physiology	2.14455487
13	MP0002148_abnormal_hypersensitivity_rea	2.07753603
14	MP0008872_abnormal_physiological_respon	2.07203165
15	MP0004145_abnormal_muscle_electrophysio	2.04783103
16	MP0003252_abnormal_bile_duct	1.86803761
17	MP0000372_irregular_coat_pigmentation	1.83420588
18	MP0001800_abnormal_humoral_immune	1.82755423
19	MP0005085_abnormal_gallbladder_physiolo	1.81279829
20	MP0001968_abnormal_touch/_nociception	1.78432716
21	MP0003724_increased_susceptibility_to	1.75976438
22	MP0003806_abnormal_nucleotide_metabolis	1.75104887
23	MP0005253_abnormal_eye_physiology	1.74605289
24	MP0006054_spinal_hemorrhage	1.74008912
25	MP0005084_abnormal_gallbladder_morpholo	1.69095750
26	MP0002736_abnormal_nociception_after	1.68390768
27	MP0009764_decreased_sensitivity_to	1.59831174
28	MP0005551_abnormal_eye_electrophysiolog	1.55164199
29	MP0002138_abnormal_hepatobiliary_system	1.53608122
30	MP0003186_abnormal_redox_activity	1.50345479
31	MP0002006_tumorigenesis	1.49639473
32	MP0002102_abnormal_ear_morphology	1.46438995
33	MP0008058_abnormal_DNA_repair	1.43523305
34	MP0008775_abnormal_heart_ventricle	1.41930418
35	MP0006036_abnormal_mitochondrial_physio	1.39516888
36	MP0002452_abnormal_antigen_presenting	1.38585178
37	MP0004885_abnormal_endolymph	1.37306799
38	MP0001905_abnormal_dopamine_level	1.37265697
39	MP0005075_abnormal_melanosome_morpholog	1.37184114
40	MP0009379_abnormal_foot_pigmentation	1.35776505
41	MP0002139_abnormal_hepatobiliary_system	1.33023632
42	MP0002723_abnormal_immune_serum	1.32200881
43	MP0006292_abnormal_olfactory_placode	1.31782472
44	MP0006035_abnormal_mitochondrial_morpho	1.28234887
45	MP0003866_abnormal_defecation	1.27310398
46	MP0003718_maternal_effect	1.26973773
47	MP0003195_calcinosis	1.26728131
48	MP0002166_altered_tumor_susceptibility	1.26723164
49	MP0000230_abnormal_systemic_arterial	1.25153824
50	MP0010094_abnormal_chromosome_stability	1.24977361
51	MP0005410_abnormal_fertilization	1.24163154
52	MP0009785_altered_susceptibility_to	1.20860416
53	MP0001501_abnormal_sleep_pattern	1.20740966
54	MP0004215_abnormal_myocardial_fiber	1.19282493
55	MP0003786_premature_aging	1.18811975
56	MP0005000_abnormal_immune_tolerance	1.18435285
57	MP0005503_abnormal_tendon_morphology	1.16808776
58	MP0005389_reproductive_system_phenotype	1.16429542
59	MP0002420_abnormal_adaptive_immunity	1.11735709
60	MP0001819_abnormal_immune_cell	1.11473572
61	MP0005360_urolithiasis	1.06787827
62	MP0003693_abnormal_embryo_hatching	1.06259329
63	MP0008995_early_reproductive_senescence	1.05542043
64	MP0001764_abnormal_homeostasis	1.04424312
65	MP0005365_abnormal_bile_salt	1.00702771
66	MP0004142_abnormal_muscle_tone	0.99156515
67	MP0009697_abnormal_copulation	0.98790049
68	MP0004043_abnormal_pH_regulation	0.96988664
69	MP0005167_abnormal_blood-brain_barrier	0.94343416
70	MP0010329_abnormal_lipoprotein_level	0.92827454
71	MP0002272_abnormal_nervous_system	0.92710638
72	MP0010155_abnormal_intestine_physiology	0.92157334
73	MP0001984_abnormal_olfaction	0.91846691
74	MP0001765_abnormal_ion_homeostasis	0.89860333
75	MP0002938_white_spotting	0.89157314
76	MP0001790_abnormal_immune_system	0.88216190
77	MP0005387_immune_system_phenotype	0.88216190
78	MP0000427_abnormal_hair_cycle	0.87947478
79	MP0005645_abnormal_hypothalamus_physiol	0.87237449
80	MP0002398_abnormal_bone_marrow	0.85714641
81	MP0002095_abnormal_skin_pigmentation	0.85605378
82	MP0005636_abnormal_mineral_homeostasis	0.84651353
83	MP0002160_abnormal_reproductive_system	0.84595541
84	MP0005319_abnormal_enzyme/_coenzyme	0.82787445
85	MP0000716_abnormal_immune_system	0.82622365
86	MP0010386_abnormal_urinary_bladder	0.81623595
87	MP0003787_abnormal_imprinting	0.81306478
88	MP0001845_abnormal_inflammatory_respons	0.80384404
89	MP0008469_abnormal_protein_level	0.79461710
90	MP0000689_abnormal_spleen_morphology	0.79399534
91	MP0003279_aneurysm	0.77119271
92	MP0009333_abnormal_splenocyte_physiolog	0.77112632
93	MP0001919_abnormal_reproductive_system	0.76319692
94	MP0008873_increased_physiological_sensi	0.76081267
95	MP0009046_muscle_twitch	0.75807231
96	MP0003436_decreased_susceptibility_to	0.74173904
97	MP0009745_abnormal_behavioral_response	0.74122083
98	MP0001119_abnormal_female_reproductive	0.71309207
99	MP0000631_abnormal_neuroendocrine_gland	0.71116879
100	MP0002419_abnormal_innate_immunity	0.70470499

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	4.05068856
2	Increased CSF lactate (HP:0002490)	3.74627776
3	Hepatocellular necrosis (HP:0001404)	3.66815016
4	Lipid accumulation in hepatocytes (HP:0006561)	3.66032686
5	Increased hepatocellular lipid droplets (HP:0006565)	3.57693616
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.55343260
7	Hepatic necrosis (HP:0002605)	3.54528226
8	Abnormal number of erythroid precursors (HP:0012131)	3.47851378
9	Congenital, generalized hypertrichosis (HP:0004540)	3.44416035
10	3-Methylglutaconic aciduria (HP:0003535)	3.40195599
11	Acute necrotizing encephalopathy (HP:0006965)	3.35372995
12	Nephronophthisis (HP:0000090)	3.23683194
13	Methylmalonic acidemia (HP:0002912)	3.22835819
14	IgG deficiency (HP:0004315)	3.14708825
15	Progressive macrocephaly (HP:0004481)	3.07863923
16	Pancreatic cysts (HP:0001737)	3.00228580
17	Renal Fanconi syndrome (HP:0001994)	2.93952172
18	Methylmalonic aciduria (HP:0012120)	2.92196571
19	Abnormality of the renal cortex (HP:0011035)	2.90786803
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89795688
21	Abnormality of the renal medulla (HP:0100957)	2.86179888
22	Type II lissencephaly (HP:0007260)	2.82152736
23	Absent/shortened dynein arms (HP:0200106)	2.78642560
24	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.78642560
25	Acute encephalopathy (HP:0006846)	2.76721602
26	Elevated erythrocyte sedimentation rate (HP:0003565)	2.73937981
27	Abolished electroretinogram (ERG) (HP:0000550)	2.70520196
28	Chronic sinusitis (HP:0011109)	2.68315838
29	Stomatitis (HP:0010280)	2.63650882
30	Increased serum lactate (HP:0002151)	2.61402823
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.52952785
32	Spontaneous abortion (HP:0005268)	2.50156928
33	Abnormal spermatogenesis (HP:0008669)	2.47594628
34	Stomach cancer (HP:0012126)	2.46762739
35	Increased intramyocellular lipid droplets (HP:0012240)	2.44319590
36	Attenuation of retinal blood vessels (HP:0007843)	2.44040033
37	Lactic acidosis (HP:0003128)	2.42493910
38	Renal cortical cysts (HP:0000803)	2.42398379
39	Abnormal biliary tract physiology (HP:0012439)	2.41518259
40	Bile duct proliferation (HP:0001408)	2.41518259
41	Cerebral edema (HP:0002181)	2.40628187
42	Testicular atrophy (HP:0000029)	2.40314638
43	Abnormality of midbrain morphology (HP:0002418)	2.40148322
44	Molar tooth sign on MRI (HP:0002419)	2.40148322
45	Azoospermia (HP:0000027)	2.39925779
46	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.39139216
47	Dicarboxylic aciduria (HP:0003215)	2.39139216
48	Abnormality of B cell number (HP:0010975)	2.37816114
49	Decreased central vision (HP:0007663)	2.36963015
50	Abnormality of urine glucose concentration (HP:0011016)	2.36841686
51	Glycosuria (HP:0003076)	2.36841686
52	Asplenia (HP:0001746)	2.36679099
53	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.35873321
54	Pancreatic fibrosis (HP:0100732)	2.35567710
55	Absent thumb (HP:0009777)	2.33966331
56	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.33865309
57	Congenital stationary night blindness (HP:0007642)	2.33285850
58	Dry hair (HP:0011359)	2.31602134
59	Increased muscle lipid content (HP:0009058)	2.26780501
60	Optic disc pallor (HP:0000543)	2.23441095
61	Carpal bone hypoplasia (HP:0001498)	2.22650719
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.22168920
63	Supernumerary spleens (HP:0009799)	2.22060971
64	CNS demyelination (HP:0007305)	2.21981301
65	Pancytopenia (HP:0001876)	2.21910730
66	Abnormality of renal resorption (HP:0011038)	2.21754089
67	IgM deficiency (HP:0002850)	2.18829469
68	Reticulocytopenia (HP:0001896)	2.17525114
69	Increased corneal curvature (HP:0100692)	2.11169828
70	Keratoconus (HP:0000563)	2.11169828
71	Hypoproteinemia (HP:0003075)	2.10831542
72	Exertional dyspnea (HP:0002875)	2.05285685
73	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.98197427
74	Respiratory failure (HP:0002878)	1.96836995
75	Reduced antithrombin III activity (HP:0001976)	1.96807473
76	Type I transferrin isoform profile (HP:0003642)	1.92497090
77	True hermaphroditism (HP:0010459)	1.87977548
78	Lethargy (HP:0001254)	1.87704853
79	Abnormality of the prostate (HP:0008775)	1.87695040
80	Ketosis (HP:0001946)	1.86810381
81	Beaking of vertebral bodies (HP:0004568)	1.86325782
82	Type 2 muscle fiber atrophy (HP:0003554)	1.85922467
83	B lymphocytopenia (HP:0010976)	1.85107734
84	Pendular nystagmus (HP:0012043)	1.85037077
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.83567214
86	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.82299754
87	Prostate neoplasm (HP:0100787)	1.81710659
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.81597211
89	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.80711889
90	Small epiphyses (HP:0010585)	1.80621124
91	Recurrent bronchitis (HP:0002837)	1.79575419
92	Epiphyseal stippling (HP:0010655)	1.78654392
93	Polydipsia (HP:0001959)	1.78478810
94	Abnormal drinking behavior (HP:0030082)	1.78478810
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78218537
96	Abnormal respiratory epithelium morphology (HP:0012253)	1.78218537
97	Abnormality of the renal collecting system (HP:0004742)	1.75195757
98	Abnormality of fatty-acid metabolism (HP:0004359)	1.74792863
99	Panhypogammaglobulinemia (HP:0003139)	1.73980909
100	Colon cancer (HP:0003003)	1.73954340

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.22566644
2	TLK1	3.74653298
3	ZAK	3.74087085
4	FRK	3.35721459
5	STK16	2.63834701
6	VRK2	2.57699960
7	PINK1	2.56125114
8	TXK	2.55261855
9	NUAK1	2.45017325
10	GRK1	2.29306159
11	ADRBK2	2.20214986
12	SCYL2	2.16242909
13	BMPR2	2.00701527
14	EIF2AK3	1.93505352
15	KIT	1.92033217
16	MAP4K2	1.68749592
17	BMPR1B	1.65884585
18	PHKG2	1.61962273
19	PHKG1	1.61962273
20	MAPKAPK3	1.47936894
21	MYLK	1.43857255
22	BCKDK	1.43392485
23	CAMKK2	1.43372629
24	CDK19	1.42233318
25	MAP3K12	1.40188305
26	VRK1	1.37761934
27	MAP4K1	1.37417005
28	TAF1	1.36666031
29	IKBKB	1.36426107
30	WNK4	1.31447876
31	STK38L	1.22940396
32	EIF2AK1	1.20591685
33	TRPM7	1.17297535
34	FES	1.15954607
35	MST4	1.10061895
36	BRSK2	1.09633732
37	MAPKAPK5	1.09193123
38	JAK3	1.07795403
39	ITK	1.06644896
40	TEC	1.04838149
41	PIK3CG	1.04748656
42	MKNK1	1.01921952
43	TIE1	1.01874300
44	OXSR1	1.00643096
45	SYK	0.97998948
46	CSF1R	0.96601240
47	MAP2K2	0.94411083
48	ERBB3	0.88467257
49	INSRR	0.86762886
50	WNK3	0.85493659
51	MAP3K14	0.81444795
52	RPS6KA5	0.81072177
53	LYN	0.78162446
54	PLK3	0.77466015
55	FLT3	0.76159766
56	MKNK2	0.75361627
57	MAP3K13	0.73257711
58	DAPK1	0.73084035
59	KDR	0.71817701
60	CSNK1G3	0.71770195
61	EIF2AK2	0.71729855
62	BTK	0.68526901
63	GRK6	0.66164474
64	CAMKK1	0.65054936
65	GRK5	0.64373643
66	NME1	0.61395897
67	DYRK2	0.61288334
68	CHUK	0.60276522
69	MATK	0.59916734
70	PLK2	0.59360399
71	WNK1	0.56319964
72	PIK3CA	0.56055923
73	IGF1R	0.53256949
74	CSNK1A1L	0.52997642
75	CSNK1G1	0.52906801
76	PLK4	0.52731571
77	ADRBK1	0.52402462
78	CSNK1G2	0.51056874
79	ACVR1B	0.47656497
80	PTK2B	0.46446402
81	MAP3K4	0.45369447
82	STK39	0.45336006
83	PRKCQ	0.44500160
84	RPS6KB2	0.44497580
85	CCNB1	0.43113064
86	LCK	0.43028863
87	ABL1	0.42769447
88	NEK1	0.41343365
89	HCK	0.40942173
90	CDK3	0.40093021
91	MAPK13	0.39373668
92	FGFR2	0.35978278
93	CDK8	0.35711847
94	AURKB	0.35469167
95	ILK	0.32188876
96	DAPK2	0.31219570
97	CHEK2	0.29707984
98	ATR	0.29646097
99	RIPK4	0.29226683
100	PRKCD	0.29081258

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.78703868
2	Caffeine metabolism_Homo sapiens_hsa00232	3.61818931
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.46613577
4	Ribosome_Homo sapiens_hsa03010	3.26033974
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.12318483
6	Parkinsons disease_Homo sapiens_hsa05012	2.96791956
7	Allograft rejection_Homo sapiens_hsa05330	2.71937315
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.57165735
9	Proteasome_Homo sapiens_hsa03050	2.53419775
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.52843002
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.45682470
12	Protein export_Homo sapiens_hsa03060	2.28378563
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.00134778
14	Alzheimers disease_Homo sapiens_hsa05010	1.86435210
15	Homologous recombination_Homo sapiens_hsa03440	1.85145446
16	RNA polymerase_Homo sapiens_hsa03020	1.82064324
17	One carbon pool by folate_Homo sapiens_hsa00670	1.73030192
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71813087
19	Huntingtons disease_Homo sapiens_hsa05016	1.71798007
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59603907
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.44638380
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.42398323
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.38577419
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.37918425
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.37617434
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33559659
27	Phototransduction_Homo sapiens_hsa04744	1.31150215
28	DNA replication_Homo sapiens_hsa03030	1.30111083
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.29332858
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23311914
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.22112252
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.22070139
33	Antigen processing and presentation_Homo sapiens_hsa04612	1.17904321
34	Mismatch repair_Homo sapiens_hsa03430	1.13927385
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.13324520
36	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.11021808
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.10543544
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06005679
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04150125
40	Basal transcription factors_Homo sapiens_hsa03022	1.02909731
41	Fanconi anemia pathway_Homo sapiens_hsa03460	1.00031511
42	Base excision repair_Homo sapiens_hsa03410	0.99928960
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99569602
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.98612866
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.97573290
46	Peroxisome_Homo sapiens_hsa04146	0.96381342
47	Purine metabolism_Homo sapiens_hsa00230	0.90460188
48	Leishmaniasis_Homo sapiens_hsa05140	0.89293113
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87430409
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87145998
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83732594
52	Viral myocarditis_Homo sapiens_hsa05416	0.81258068
53	Propanoate metabolism_Homo sapiens_hsa00640	0.80741937
54	Glutathione metabolism_Homo sapiens_hsa00480	0.79597030
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78172151
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77197894
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77144530
58	RNA degradation_Homo sapiens_hsa03018	0.77081026
59	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.76100277
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75955294
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74653193
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74582192
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72977161
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72430865
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.71567417
66	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65778972
67	Butanoate metabolism_Homo sapiens_hsa00650	0.64669737
68	Retinol metabolism_Homo sapiens_hsa00830	0.63924779
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62296987
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61748058
71	Metabolic pathways_Homo sapiens_hsa01100	0.61701241
72	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.60613528
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58510494
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.55039152
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.54826394
76	Mineral absorption_Homo sapiens_hsa04978	0.54775140
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54159079
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52140682
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50842345
80	Olfactory transduction_Homo sapiens_hsa04740	0.48883806
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47284054
82	Regulation of autophagy_Homo sapiens_hsa04140	0.44694704
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43470345
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.43243840
85	Sulfur metabolism_Homo sapiens_hsa00920	0.43060559
86	ABC transporters_Homo sapiens_hsa02010	0.42729906
87	RNA transport_Homo sapiens_hsa03013	0.41849550
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.41508006
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.38634145
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36775828
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36292478
92	Toxoplasmosis_Homo sapiens_hsa05145	0.29440684
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.27157012
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26008588
95	Tuberculosis_Homo sapiens_hsa05152	0.25099131
96	Herpes simplex infection_Homo sapiens_hsa05168	0.23878930
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.21996608
98	Fatty acid elongation_Homo sapiens_hsa00062	0.21951542
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.20554133
100	Taste transduction_Homo sapiens_hsa04742	0.18408140

RPS4XP18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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