ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.61117124
2	ATP synthesis coupled proton transport (GO:0015986)	5.61117124
3	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.52463841
4	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.52463841
5	ribosomal small subunit assembly (GO:0000028)	5.48371292
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.32094984
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.89003494
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.89003494
9	NADH dehydrogenase complex assembly (GO:0010257)	4.89003494
10	behavioral response to nicotine (GO:0035095)	4.83237819
11	protein complex biogenesis (GO:0070271)	4.80343436
12	viral transcription (GO:0019083)	4.69753300
13	rRNA modification (GO:0000154)	4.69204679
14	ribosomal small subunit biogenesis (GO:0042274)	4.67041810
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.62061823
16	translational termination (GO:0006415)	4.51184517
17	maturation of SSU-rRNA (GO:0030490)	4.50176992
18	mitochondrial respiratory chain complex assembly (GO:0033108)	4.28421287
19	DNA deamination (GO:0045006)	4.26036616
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.14769905
21	translational elongation (GO:0006414)	4.11691628
22	cotranslational protein targeting to membrane (GO:0006613)	4.07571089
23	respiratory electron transport chain (GO:0022904)	4.05588060
24	protein targeting to ER (GO:0045047)	4.03893124
25	electron transport chain (GO:0022900)	4.03734616
26	chaperone-mediated protein transport (GO:0072321)	4.02030649
27	GTP biosynthetic process (GO:0006183)	3.98940319
28	peptidyl-histidine modification (GO:0018202)	3.93284205
29	proteasome assembly (GO:0043248)	3.90556423
30	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.90169358
31	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.86507312
32	protein localization to endoplasmic reticulum (GO:0070972)	3.83433890
33	termination of RNA polymerase III transcription (GO:0006386)	3.69107391
34	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.69107391
35	gonadal mesoderm development (GO:0007506)	3.67786400
36	inner mitochondrial membrane organization (GO:0007007)	3.63756635
37	rRNA methylation (GO:0031167)	3.62771831
38	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.59540308
39	ribosomal large subunit biogenesis (GO:0042273)	3.57566045
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.56002858
41	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.55352139
42	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.49490303
43	UTP metabolic process (GO:0046051)	3.49357123
44	translation (GO:0006412)	3.48785151
45	platelet dense granule organization (GO:0060155)	3.44408347
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.44343646
47	UTP biosynthetic process (GO:0006228)	3.42752977
48	cellular protein complex disassembly (GO:0043624)	3.35885329
49	translational initiation (GO:0006413)	3.34306915
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.33346646
51	cellular component biogenesis (GO:0044085)	3.31850730
52	viral life cycle (GO:0019058)	3.31615807
53	regulation of cellular amino acid metabolic process (GO:0006521)	3.30615851
54	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.26386835
55	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.19669198
56	positive regulation of prostaglandin secretion (GO:0032308)	3.18239050
57	purine nucleotide salvage (GO:0032261)	3.14573310
58	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.13524960
59	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.13524960
60	ATP biosynthetic process (GO:0006754)	3.12632855
61	intracellular protein transmembrane import (GO:0044743)	3.12613792
62	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.12423591
63	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.11810018
64	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.11810018
65	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.11810018
66	adenosine metabolic process (GO:0046085)	3.08425980
67	regulation of immunoglobulin secretion (GO:0051023)	3.05542033
68	ribonucleoprotein complex biogenesis (GO:0022613)	3.05313348
69	hydrogen ion transmembrane transport (GO:1902600)	3.04989962
70	protein neddylation (GO:0045116)	3.04857492
71	folic acid-containing compound biosynthetic process (GO:0009396)	3.03610827
72	pseudouridine synthesis (GO:0001522)	3.03547926
73	protein-cofactor linkage (GO:0018065)	3.00230168
74	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.97863489
75	mannosylation (GO:0097502)	2.96516204
76	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.95128554
77	rRNA processing (GO:0006364)	2.94662881
78	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.94112051
79	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.94112051
80	CTP biosynthetic process (GO:0006241)	2.92861510
81	CTP metabolic process (GO:0046036)	2.92861510
82	respiratory chain complex IV assembly (GO:0008535)	2.92252842
83	rRNA metabolic process (GO:0016072)	2.90926989
84	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.88722766
85	proton transport (GO:0015992)	2.87777022
86	tryptophan catabolic process (GO:0006569)	2.87655825
87	indole-containing compound catabolic process (GO:0042436)	2.87655825
88	indolalkylamine catabolic process (GO:0046218)	2.87655825
89	hydrogen transport (GO:0006818)	2.86837446
90	tRNA processing (GO:0008033)	2.86049996
91	regulation of chronic inflammatory response (GO:0002676)	2.82804737
92	protein targeting to mitochondrion (GO:0006626)	2.80443966
93	guanosine-containing compound biosynthetic process (GO:1901070)	2.79982500
94	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.78194899
95	maturation of 5.8S rRNA (GO:0000460)	2.75303518
96	protein complex disassembly (GO:0043241)	2.74599115
97	protein peptidyl-prolyl isomerization (GO:0000413)	2.70472130
98	protein localization to mitochondrion (GO:0070585)	2.70321771
99	amino acid salvage (GO:0043102)	2.68765796
100	L-methionine biosynthetic process (GO:0071265)	2.68765796

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.90228952
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.46925956
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.10473240
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.07267866
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.33747850
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.33099577
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.16216267
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.08638093
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.95649111
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.94602812
11	VDR_22108803_ChIP-Seq_LS180_Human	2.90857089
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.49014473
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34277053
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.28985517
15	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.14649735
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.13334767
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.11281779
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.07756189
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.98988144
20	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.94001453
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.93063733
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.90984989
23	FUS_26573619_Chip-Seq_HEK293_Human	1.88497856
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.80737509
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75024047
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.73054232
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.69047474
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.65168833
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62202204
30	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.59569901
31	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.57140054
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.48862421
33	EWS_26573619_Chip-Seq_HEK293_Human	1.48085248
34	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.39948578
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.39302578
36	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35440008
37	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35440008
38	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.33059842
39	AR_20517297_ChIP-Seq_VCAP_Human	1.31998929
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.31734867
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30884921
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30884921
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29749489
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.29332941
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28973980
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28473483
47	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.25705966
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.25496144
49	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.23255590
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.23222686
51	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.22103409
52	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21745585
53	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21459379
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21236228
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21167949
56	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.21134819
57	DCP1A_22483619_ChIP-Seq_HELA_Human	1.20432579
58	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.19521563
59	XRN2_22483619_ChIP-Seq_HELA_Human	1.19017885
60	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18973017
61	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18450531
62	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.16778818
63	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.16598023
64	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16265369
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15770837
66	CIITA_25753668_ChIP-Seq_RAJI_Human	1.14457726
67	EZH2_22144423_ChIP-Seq_EOC_Human	1.14432521
68	NCOR_22424771_ChIP-Seq_293T_Human	1.14317018
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13514488
70	GATA3_26560356_Chip-Seq_TH2_Human	1.12429682
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09733178
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09301822
73	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09161639
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.08935674
75	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.06427153
76	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.05736124
77	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.05553005
78	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05440172
79	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.05231355
80	ERG_20517297_ChIP-Seq_VCAP_Human	1.03511516
81	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02714402
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02637428
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00213705
84	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.97670633
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97238301
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96586921
87	STAT1_20625510_ChIP-Seq_HELA_Human	0.96315201
88	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94951286
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94286584
90	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93270380
91	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93232316
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92943734
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.92112734
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.91341918
95	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.91222885
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90894223
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.90463296
98	ERA_21632823_ChIP-Seq_H3396_Human	0.87664387
99	IGF1R_20145208_ChIP-Seq_DFB_Human	0.86398628
100	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.86351999

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	4.66854543
2	MP0009379_abnormal_foot_pigmentation	4.18741789
3	MP0001835_abnormal_antigen_presentation	3.55005028
4	MP0008875_abnormal_xenobiotic_pharmacok	3.46111466
5	MP0005646_abnormal_pituitary_gland	2.99679702
6	MP0002138_abnormal_hepatobiliary_system	2.77639194
7	MP0002736_abnormal_nociception_after	2.31285140
8	MP0000685_abnormal_immune_system	2.24338803
9	MP0003806_abnormal_nucleotide_metabolis	2.22106689
10	MP0005075_abnormal_melanosome_morpholog	2.17177477
11	MP0005671_abnormal_response_to	2.17007567
12	MP0004885_abnormal_endolymph	2.05699496
13	MP0006072_abnormal_retinal_apoptosis	1.99588362
14	MP0003786_premature_aging	1.95123166
15	MP0008995_early_reproductive_senescence	1.89117552
16	MP0004147_increased_porphyrin_level	1.88375489
17	MP0008872_abnormal_physiological_respon	1.81934739
18	MP0001968_abnormal_touch/_nociception	1.79807943
19	MP0006292_abnormal_olfactory_placode	1.79357920
20	MP0000516_abnormal_urinary_system	1.76406869
21	MP0005367_renal/urinary_system_phenotyp	1.76406869
22	MP0003186_abnormal_redox_activity	1.73802523
23	MP0002837_dystrophic_cardiac_calcinosis	1.63904896
24	MP0005551_abnormal_eye_electrophysiolog	1.60294915
25	MP0001293_anophthalmia	1.59263481
26	MP0003724_increased_susceptibility_to	1.58663423
27	MP0000372_irregular_coat_pigmentation	1.54889772
28	MP0008877_abnormal_DNA_methylation	1.54320974
29	MP0001800_abnormal_humoral_immune	1.53172695
30	MP0004145_abnormal_muscle_electrophysio	1.49234352
31	MP0002095_abnormal_skin_pigmentation	1.47462502
32	MP0002148_abnormal_hypersensitivity_rea	1.45604040
33	MP0003283_abnormal_digestive_organ	1.45150808
34	MP0005389_reproductive_system_phenotype	1.44687871
35	MP0002234_abnormal_pharynx_morphology	1.44098450
36	MP0002277_abnormal_respiratory_mucosa	1.43904863
37	MP0001919_abnormal_reproductive_system	1.42704942
38	MP0003646_muscle_fatigue	1.40018156
39	MP0009785_altered_susceptibility_to	1.38432922
40	MP0002938_white_spotting	1.37898218
41	MP0004142_abnormal_muscle_tone	1.37059514
42	MP0000538_abnormal_urinary_bladder	1.36472607
43	MP0005332_abnormal_amino_acid	1.34572842
44	MP0009333_abnormal_splenocyte_physiolog	1.32930640
45	MP0001986_abnormal_taste_sensitivity	1.32237205
46	MP0002876_abnormal_thyroid_physiology	1.30265039
47	MP0001905_abnormal_dopamine_level	1.29058097
48	MP0008775_abnormal_heart_ventricle	1.27635541
49	MP0004043_abnormal_pH_regulation	1.24070864
50	MP0005387_immune_system_phenotype	1.23734905
51	MP0001790_abnormal_immune_system	1.23734905
52	MP0003718_maternal_effect	1.19136833
53	MP0001764_abnormal_homeostasis	1.17390294
54	MP0009764_decreased_sensitivity_to	1.16112216
55	MP0002160_abnormal_reproductive_system	1.15840790
56	MP0005253_abnormal_eye_physiology	1.14704004
57	MP0006276_abnormal_autonomic_nervous	1.07391182
58	MP0000013_abnormal_adipose_tissue	1.07212227
59	MP0001756_abnormal_urination	1.06083091
60	MP0005410_abnormal_fertilization	1.05864939
61	MP0003195_calcinosis	1.05298135
62	MP0005636_abnormal_mineral_homeostasis	1.05063981
63	MP0006036_abnormal_mitochondrial_physio	1.03494222
64	MP0003045_fibrosis	1.03182103
65	MP0003880_abnormal_central_pattern	1.02078784
66	MP0003866_abnormal_defecation	1.00826690
67	MP0005085_abnormal_gallbladder_physiolo	0.99958548
68	MP0000631_abnormal_neuroendocrine_gland	0.97491024
69	MP0001661_extended_life_span	0.97264408
70	MP0001440_abnormal_grooming_behavior	0.96534963
71	MP0002272_abnormal_nervous_system	0.96448391
72	MP0005000_abnormal_immune_tolerance	0.95659079
73	MP0005084_abnormal_gallbladder_morpholo	0.95422769
74	MP0002396_abnormal_hematopoietic_system	0.95327768
75	MP0002166_altered_tumor_susceptibility	0.93974831
76	MP0003011_delayed_dark_adaptation	0.92251419
77	MP0001873_stomach_inflammation	0.92023193
78	MP0002006_tumorigenesis	0.91854196
79	MP0005165_increased_susceptibility_to	0.91618068
80	MP0002452_abnormal_antigen_presenting	0.91417503
81	MP0002735_abnormal_chemical_nociception	0.91214640
82	MP0002723_abnormal_immune_serum	0.90042276
83	MP0003787_abnormal_imprinting	0.88036142
84	MP0009745_abnormal_behavioral_response	0.86880756
85	MP0005645_abnormal_hypothalamus_physiol	0.85404284
86	MP0005670_abnormal_white_adipose	0.84304222
87	MP0002210_abnormal_sex_determination	0.80676311
88	MP0001501_abnormal_sleep_pattern	0.79277902
89	MP0004742_abnormal_vestibular_system	0.79041685
90	MP0009643_abnormal_urine_homeostasis	0.78084677
91	MP0001663_abnormal_digestive_system	0.77425262
92	MP0001485_abnormal_pinna_reflex	0.77079265
93	MP0001819_abnormal_immune_cell	0.75996041
94	MP0002102_abnormal_ear_morphology	0.75156537
95	MP0004019_abnormal_vitamin_homeostasis	0.72492380
96	MP0005319_abnormal_enzyme/_coenzyme	0.72380187
97	MP0002420_abnormal_adaptive_immunity	0.72009864
98	MP0001944_abnormal_pancreas_morphology	0.71097426
99	MP0000653_abnormal_sex_gland	0.70348660
100	MP0001853_heart_inflammation	0.66333837

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.69904935
2	Mitochondrial inheritance (HP:0001427)	4.19892143
3	Increased CSF lactate (HP:0002490)	4.13681222
4	Acute encephalopathy (HP:0006846)	4.12754464
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.09754374
6	Abnormality of alanine metabolism (HP:0010916)	4.09754374
7	Hyperalaninemia (HP:0003348)	4.09754374
8	Progressive macrocephaly (HP:0004481)	4.03387612
9	Abnormal mitochondria in muscle tissue (HP:0008316)	4.02140784
10	Congenital, generalized hypertrichosis (HP:0004540)	3.74592328
11	Hepatocellular necrosis (HP:0001404)	3.68548691
12	Reticulocytopenia (HP:0001896)	3.46388313
13	3-Methylglutaconic aciduria (HP:0003535)	3.44297701
14	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.40888005
15	Hepatic necrosis (HP:0002605)	3.37710710
16	Increased hepatocellular lipid droplets (HP:0006565)	3.29514963
17	Type I transferrin isoform profile (HP:0003642)	3.19094184
18	Constricted visual fields (HP:0001133)	3.10180961
19	Cerebral edema (HP:0002181)	3.02413664
20	Abnormality of cells of the erythroid lineage (HP:0012130)	3.00510976
21	Renal Fanconi syndrome (HP:0001994)	2.89858529
22	Increased serum lactate (HP:0002151)	2.89712044
23	True hermaphroditism (HP:0010459)	2.88719263
24	Pancreatic cysts (HP:0001737)	2.87146177
25	Lactic acidosis (HP:0003128)	2.76908882
26	Lipid accumulation in hepatocytes (HP:0006561)	2.76463246
27	Optic disc pallor (HP:0000543)	2.73732685
28	Molar tooth sign on MRI (HP:0002419)	2.73173759
29	Abnormality of midbrain morphology (HP:0002418)	2.73173759
30	Absent/shortened dynein arms (HP:0200106)	2.72305013
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.72305013
32	Pancreatic fibrosis (HP:0100732)	2.71385790
33	Abnormal number of erythroid precursors (HP:0012131)	2.54232012
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.54004885
35	Pendular nystagmus (HP:0012043)	2.52943620
36	Lethargy (HP:0001254)	2.51470782
37	Abolished electroretinogram (ERG) (HP:0000550)	2.50348166
38	Congenital stationary night blindness (HP:0007642)	2.44086284
39	Exertional dyspnea (HP:0002875)	2.40936761
40	Type II lissencephaly (HP:0007260)	2.40668019
41	Macrocytic anemia (HP:0001972)	2.38966234
42	Generalized aminoaciduria (HP:0002909)	2.38683138
43	Nephronophthisis (HP:0000090)	2.38219799
44	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.32522998
45	Stomatitis (HP:0010280)	2.31748034
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.30287624
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.30287624
48	Abnormal protein glycosylation (HP:0012346)	2.23697068
49	Abnormal glycosylation (HP:0012345)	2.23697068
50	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.23697068
51	Abnormal protein N-linked glycosylation (HP:0012347)	2.23697068
52	Congenital sensorineural hearing impairment (HP:0008527)	2.23227737
53	Respiratory failure (HP:0002878)	2.22557540
54	Type 2 muscle fiber atrophy (HP:0003554)	2.17922031
55	Cerebral palsy (HP:0100021)	2.12683506
56	Stenosis of the external auditory canal (HP:0000402)	2.06399017
57	Attenuation of retinal blood vessels (HP:0007843)	2.05225924
58	Chronic otitis media (HP:0000389)	2.04166348
59	Abnormality of the labia minora (HP:0012880)	2.03599310
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.02925950
61	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.02925950
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.02427280
63	Hemoptysis (HP:0002105)	2.01846203
64	Birth length less than 3rd percentile (HP:0003561)	1.97131211
65	Abnormality of the prostate (HP:0008775)	1.96338174
66	Chronic hepatic failure (HP:0100626)	1.95968904
67	Poor speech (HP:0002465)	1.94089280
68	Hypomagnesemia (HP:0002917)	1.93352889
69	Leukodystrophy (HP:0002415)	1.91700025
70	Increased intramyocellular lipid droplets (HP:0012240)	1.90973980
71	Abnormality of the renal cortex (HP:0011035)	1.90496911
72	Exercise intolerance (HP:0003546)	1.89768535
73	Abnormality of serum amino acid levels (HP:0003112)	1.89428455
74	Chronic sinusitis (HP:0011109)	1.89096934
75	Abnormality of the renal medulla (HP:0100957)	1.88783226
76	Elevated erythrocyte sedimentation rate (HP:0003565)	1.87586410
77	Aplasia/hypoplasia of the uterus (HP:0008684)	1.87082604
78	Glycosuria (HP:0003076)	1.87033417
79	Abnormality of urine glucose concentration (HP:0011016)	1.87033417
80	Delayed CNS myelination (HP:0002188)	1.85994312
81	Polydipsia (HP:0001959)	1.85948941
82	Abnormal drinking behavior (HP:0030082)	1.85948941
83	Anorexia (HP:0002039)	1.85121774
84	Severe muscular hypotonia (HP:0006829)	1.84975588
85	Abnormality of renal resorption (HP:0011038)	1.83119012
86	Chorioretinal atrophy (HP:0000533)	1.82958154
87	IgG deficiency (HP:0004315)	1.81206632
88	Abnormality of magnesium homeostasis (HP:0004921)	1.80817294
89	Muscle fiber atrophy (HP:0100295)	1.80362562
90	Sclerocornea (HP:0000647)	1.79829586
91	Absent thumb (HP:0009777)	1.79595871
92	Methylmalonic acidemia (HP:0002912)	1.79433274
93	Increased corneal curvature (HP:0100692)	1.79134110
94	Keratoconus (HP:0000563)	1.79134110
95	Abnormal rod and cone electroretinograms (HP:0008323)	1.78018394
96	Testicular atrophy (HP:0000029)	1.76685285
97	Hyperphosphaturia (HP:0003109)	1.75720503
98	Pallor (HP:0000980)	1.73858829
99	Respiratory difficulties (HP:0002880)	1.72336551
100	Male pseudohermaphroditism (HP:0000037)	1.71175322

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.06163860
2	CDK19	2.75817839
3	KIT	2.66428080
4	STK16	2.57872501
5	BMPR1B	2.43558598
6	NME2	2.41014142
7	NUAK1	2.36297952
8	FRK	2.32742805
9	ADRBK2	2.20494737
10	PHKG2	2.14993907
11	PHKG1	2.14993907
12	BCKDK	2.11965547
13	INSRR	2.02344846
14	TAOK3	1.94843015
15	TXK	1.93553274
16	FLT3	1.86967296
17	ACVR1B	1.86060032
18	TAF1	1.80235499
19	VRK1	1.68195300
20	WNK4	1.67995621
21	OXSR1	1.67499006
22	DYRK2	1.62915043
23	NME1	1.62382803
24	GRK1	1.59905323
25	MAP3K12	1.57608688
26	MST4	1.52542081
27	EIF2AK1	1.46557012
28	TLK1	1.46485609
29	EPHB2	1.45025614
30	PINK1	1.43959778
31	MAP4K1	1.42541072
32	JAK3	1.39333124
33	MAP4K2	1.37064123
34	MAP2K6	1.22730147
35	BMPR2	1.19047370
36	MAPKAPK3	1.18254634
37	ZAK	1.16094909
38	TSSK6	1.12844610
39	PIK3CA	1.09470230
40	RPS6KB2	1.08086814
41	KDR	1.02851777
42	ADRBK1	0.99833428
43	TEC	0.98671453
44	PASK	0.97873413
45	TGFBR1	0.96858789
46	SRPK1	0.96394457
47	BUB1	0.89181295
48	MKNK2	0.85763166
49	MKNK1	0.85621679
50	SYK	0.82369285
51	TIE1	0.81546574
52	GRK7	0.80354097
53	IKBKB	0.78664879
54	DAPK1	0.78259103
55	NEK1	0.78229117
56	CSNK1G2	0.76952219
57	ITK	0.76932013
58	CAMKK2	0.76612833
59	MYLK	0.72589161
60	TRIM28	0.71870840
61	WNK3	0.71214165
62	PLK3	0.70309672
63	RIPK4	0.68180331
64	AURKA	0.66029319
65	WNK1	0.62774402
66	PBK	0.61125625
67	MAP3K11	0.59858480
68	FES	0.58577040
69	RPS6KA5	0.55970861
70	OBSCN	0.55379902
71	CSNK1G3	0.52644515
72	IKBKE	0.52252064
73	PRKCE	0.51563632
74	CCNB1	0.51263338
75	CSF1R	0.50283659
76	PNCK	0.50144512
77	DAPK2	0.49177295
78	MAP2K7	0.49125328
79	DAPK3	0.47693402
80	CSNK2A1	0.47057039
81	STK39	0.46931474
82	CSNK1G1	0.46515132
83	PIK3CG	0.46420934
84	CSNK2A2	0.45519508
85	PRKCI	0.44993816
86	ABL2	0.44708709
87	LCK	0.43868490
88	CDK8	0.42821884
89	CDK9	0.41546511
90	MAPK13	0.41481848
91	PRKCG	0.41266384
92	PRKCQ	0.40840092
93	SGK494	0.40716918
94	SGK223	0.40716918
95	PDK2	0.40201495
96	MAPKAPK5	0.40137373
97	CSNK1A1	0.39893126
98	LIMK1	0.39476354
99	TYK2	0.38440225
100	PRKACA	0.36109405

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.22164965
2	Ribosome_Homo sapiens_hsa03010	4.05855080
3	Proteasome_Homo sapiens_hsa03050	3.79691626
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.60714997
5	Allograft rejection_Homo sapiens_hsa05330	3.23994475
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.08885067
7	Parkinsons disease_Homo sapiens_hsa05012	2.97260473
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.93073095
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.59141455
10	RNA polymerase_Homo sapiens_hsa03020	2.47175951
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.35019313
12	Alzheimers disease_Homo sapiens_hsa05010	1.97537237
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.97520158
14	Huntingtons disease_Homo sapiens_hsa05016	1.92032521
15	One carbon pool by folate_Homo sapiens_hsa00670	1.86661822
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.85518700
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.85076488
18	Protein export_Homo sapiens_hsa03060	1.83963672
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.83203036
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.67874091
21	Caffeine metabolism_Homo sapiens_hsa00232	1.51463256
22	RNA degradation_Homo sapiens_hsa03018	1.41543784
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.40640798
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28176031
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26751881
26	Homologous recombination_Homo sapiens_hsa03440	1.23601487
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.22227192
28	Peroxisome_Homo sapiens_hsa04146	1.20186626
29	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.14135094
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14016129
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.13902017
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10973224
33	Propanoate metabolism_Homo sapiens_hsa00640	1.07142671
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.05024322
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04517702
36	Viral myocarditis_Homo sapiens_hsa05416	0.97170729
37	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97142762
38	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96761436
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.96165247
40	Primary immunodeficiency_Homo sapiens_hsa05340	0.93398653
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.92178354
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91344396
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88165410
44	Purine metabolism_Homo sapiens_hsa00230	0.87749920
45	Phototransduction_Homo sapiens_hsa04744	0.81158441
46	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80613574
47	Spliceosome_Homo sapiens_hsa03040	0.80450705
48	Base excision repair_Homo sapiens_hsa03410	0.80364174
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76040166
50	Regulation of autophagy_Homo sapiens_hsa04140	0.74993683
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73656372
52	Butanoate metabolism_Homo sapiens_hsa00650	0.72218205
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72023644
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71051114
55	Basal transcription factors_Homo sapiens_hsa03022	0.70225667
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68623956
57	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.68040871
58	Sulfur relay system_Homo sapiens_hsa04122	0.67377155
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64319580
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63974369
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63861328
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63375323
63	Retinol metabolism_Homo sapiens_hsa00830	0.61494411
64	Metabolic pathways_Homo sapiens_hsa01100	0.60622278
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.60190304
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60187400
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58943323
68	Folate biosynthesis_Homo sapiens_hsa00790	0.58350912
69	Leishmaniasis_Homo sapiens_hsa05140	0.57929738
70	Fatty acid elongation_Homo sapiens_hsa00062	0.56673783
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55879448
72	RNA transport_Homo sapiens_hsa03013	0.55412697
73	DNA replication_Homo sapiens_hsa03030	0.53953856
74	Glutathione metabolism_Homo sapiens_hsa00480	0.52231398
75	Nucleotide excision repair_Homo sapiens_hsa03420	0.49858323
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47861924
77	Salivary secretion_Homo sapiens_hsa04970	0.47840884
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44530790
79	Sulfur metabolism_Homo sapiens_hsa00920	0.44506729
80	Mismatch repair_Homo sapiens_hsa03430	0.42045433
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41077936
82	Olfactory transduction_Homo sapiens_hsa04740	0.40819665
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39743091
84	Morphine addiction_Homo sapiens_hsa05032	0.39659235
85	Mineral absorption_Homo sapiens_hsa04978	0.35767457
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33468576
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32800141
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.32368776
89	Fatty acid degradation_Homo sapiens_hsa00071	0.30277138
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.29620305
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27885303
92	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.27345568
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.25843226
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25141087
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.24878330
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24114669
97	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.23231139
98	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.22432477
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.20476650
100	Nicotine addiction_Homo sapiens_hsa05033	0.18573424

RPS4XP19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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