ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.18219764
2	maturation of SSU-rRNA (GO:0030490)	7.11577095
3	viral transcription (GO:0019083)	6.35878495
4	translational termination (GO:0006415)	6.17141255
5	ribosomal small subunit biogenesis (GO:0042274)	5.80190439
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.38545784
7	DNA deamination (GO:0045006)	5.37587437
8	ATP synthesis coupled proton transport (GO:0015986)	5.33387686
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.33387686
10	cotranslational protein targeting to membrane (GO:0006613)	5.29344601
11	translational elongation (GO:0006414)	5.27357315
12	protein targeting to ER (GO:0045047)	5.25872487
13	ribosomal large subunit biogenesis (GO:0042273)	5.16563179
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.00570001
15	protein localization to endoplasmic reticulum (GO:0070972)	4.95799493
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.86421803
17	chaperone-mediated protein transport (GO:0072321)	4.82758327
18	cellular protein complex disassembly (GO:0043624)	4.66473049
19	viral life cycle (GO:0019058)	4.56652945
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.52970056
21	behavioral response to nicotine (GO:0035095)	4.47571348
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.28774686
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.28199166
24	NADH dehydrogenase complex assembly (GO:0010257)	4.28199166
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.28199166
26	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.27045901
27	translational initiation (GO:0006413)	4.25187483
28	protein complex biogenesis (GO:0070271)	4.10165758
29	protein neddylation (GO:0045116)	3.96644100
30	respiratory electron transport chain (GO:0022904)	3.93996257
31	translation (GO:0006412)	3.93436884
32	protein complex disassembly (GO:0043241)	3.93017763
33	electron transport chain (GO:0022900)	3.92278431
34	macromolecular complex disassembly (GO:0032984)	3.76146760
35	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.75708359
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.71780879
37	kynurenine metabolic process (GO:0070189)	3.61143143
38	ribonucleoprotein complex biogenesis (GO:0022613)	3.58915852
39	cellular component biogenesis (GO:0044085)	3.58336635
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.57119134
41	GTP biosynthetic process (GO:0006183)	3.51495171
42	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.48233822
43	base-excision repair, AP site formation (GO:0006285)	3.45303202
44	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.43539175
45	termination of RNA polymerase III transcription (GO:0006386)	3.43539175
46	protein targeting to membrane (GO:0006612)	3.41101687
47	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.40092847
48	tryptophan catabolic process (GO:0006569)	3.40053150
49	indole-containing compound catabolic process (GO:0042436)	3.40053150
50	indolalkylamine catabolic process (GO:0046218)	3.40053150
51	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.34058752
52	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.32151799
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.31917137
54	regulation of cilium movement (GO:0003352)	3.26096949
55	ATP biosynthetic process (GO:0006754)	3.25734600
56	mRNA catabolic process (GO:0006402)	3.22693713
57	hydrogen ion transmembrane transport (GO:1902600)	3.17409710
58	rRNA metabolic process (GO:0016072)	3.17353042
59	rRNA processing (GO:0006364)	3.16742965
60	pyrimidine nucleotide catabolic process (GO:0006244)	3.10743665
61	pseudouridine synthesis (GO:0001522)	3.09763361
62	UTP metabolic process (GO:0046051)	3.08445182
63	protein-cofactor linkage (GO:0018065)	3.04021143
64	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.99076418
65	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.99076418
66	proteasome assembly (GO:0043248)	2.98106056
67	proton transport (GO:0015992)	2.97361731
68	UTP biosynthetic process (GO:0006228)	2.96331595
69	L-fucose catabolic process (GO:0042355)	2.96082352
70	fucose catabolic process (GO:0019317)	2.96082352
71	L-fucose metabolic process (GO:0042354)	2.96082352
72	hydrogen transport (GO:0006818)	2.94100733
73	RNA catabolic process (GO:0006401)	2.92541038
74	negative regulation of T cell differentiation in thymus (GO:0033085)	2.90008986
75	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.89364669
76	rRNA catabolic process (GO:0016075)	2.87935334
77	water-soluble vitamin biosynthetic process (GO:0042364)	2.87521485
78	respiratory chain complex IV assembly (GO:0008535)	2.84510461
79	protein polyglutamylation (GO:0018095)	2.80508799
80	peptidyl-histidine modification (GO:0018202)	2.78268613
81	positive regulation of prostaglandin secretion (GO:0032308)	2.75034481
82	tryptophan metabolic process (GO:0006568)	2.73752574
83	inner mitochondrial membrane organization (GO:0007007)	2.72960317
84	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.72494733
85	tRNA processing (GO:0008033)	2.70154556
86	intracellular protein transmembrane import (GO:0044743)	2.69404484
87	platelet dense granule organization (GO:0060155)	2.66569948
88	cellular biogenic amine catabolic process (GO:0042402)	2.63535099
89	amine catabolic process (GO:0009310)	2.63535099
90	substrate-independent telencephalic tangential migration (GO:0021826)	2.63165339
91	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.63165339
92	cytochrome complex assembly (GO:0017004)	2.62938218
93	indolalkylamine metabolic process (GO:0006586)	2.62739765
94	cytidine metabolic process (GO:0046087)	2.60517836
95	cytidine catabolic process (GO:0006216)	2.60517836
96	cytidine deamination (GO:0009972)	2.60517836
97	positive regulation of fatty acid transport (GO:2000193)	2.60500834
98	regulation of microtubule-based movement (GO:0060632)	2.60127598
99	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.58906007
100	piRNA metabolic process (GO:0034587)	2.56077587

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.28153105
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.82862888
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.43255383
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.36431921
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.02171249
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.93179229
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.90718630
8	VDR_22108803_ChIP-Seq_LS180_Human	2.87837273
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.65390101
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.61725804
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.55147477
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.54073298
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.53561866
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.32897286
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.23297898
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.09685590
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.08596265
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.03266670
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.01066412
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.99320645
21	TTF2_22483619_ChIP-Seq_HELA_Human	1.94785846
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.90926077
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.86688212
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80912950
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.75699319
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.74628933
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69907371
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.69156047
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.68484503
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.62133777
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.60653316
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.60019706
33	FUS_26573619_Chip-Seq_HEK293_Human	1.53264228
34	EWS_26573619_Chip-Seq_HEK293_Human	1.51319430
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46495148
36	XRN2_22483619_ChIP-Seq_HELA_Human	1.44678558
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43874077
38	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.39945628
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.36704034
40	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.35857658
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.35568088
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35298370
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34584850
44	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29495730
45	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.25739736
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23275461
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.21863231
48	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.21331281
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20537531
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20097683
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.18077786
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17039858
53	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.16736205
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16412070
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16412070
56	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.14706478
57	ERA_21632823_ChIP-Seq_H3396_Human	1.13567267
58	AR_20517297_ChIP-Seq_VCAP_Human	1.12484948
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12254032
60	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.12171280
61	NCOR_22424771_ChIP-Seq_293T_Human	1.10880694
62	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.09207863
63	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.08991649
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08501454
65	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.07531059
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06036918
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05472589
68	P53_21459846_ChIP-Seq_SAOS-2_Human	1.03854451
69	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.03446633
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02353056
71	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.02140279
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.01713818
73	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00412799
74	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.00231954
75	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00214301
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99698984
77	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.98493420
78	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98279864
79	SOX2_19829295_ChIP-Seq_ESCs_Human	0.98103601
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.98103601
81	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.97606406
82	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97549169
83	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.97219018
84	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94392615
85	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.93605863
86	MYC_19829295_ChIP-Seq_ESCs_Human	0.93590106
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91999504
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.91486717
89	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.91190089
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.89864076
91	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.89781447
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.89498680
93	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.89394383
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89209787
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88464556
96	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87287955
97	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.86646474
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86119028
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.85978930
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.85747466

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.45389447
2	MP0006292_abnormal_olfactory_placode	3.52758161
3	MP0008877_abnormal_DNA_methylation	2.89916977
4	MP0003787_abnormal_imprinting	2.70911122
5	MP0006072_abnormal_retinal_apoptosis	2.61021520
6	MP0004142_abnormal_muscle_tone	2.41341253
7	MP0008875_abnormal_xenobiotic_pharmacok	2.34786657
8	MP0005423_abnormal_somatic_nervous	2.33268782
9	MP0004145_abnormal_muscle_electrophysio	2.07370076
10	MP0003646_muscle_fatigue	1.99806834
11	MP0003011_delayed_dark_adaptation	1.97451358
12	MP0001968_abnormal_touch/_nociception	1.90301610
13	MP0005551_abnormal_eye_electrophysiolog	1.80464077
14	MP0001986_abnormal_taste_sensitivity	1.78599124
15	MP0006276_abnormal_autonomic_nervous	1.78566643
16	MP0002102_abnormal_ear_morphology	1.76173756
17	MP0005671_abnormal_response_to	1.75660628
18	MP0005646_abnormal_pituitary_gland	1.74596735
19	MP0005645_abnormal_hypothalamus_physiol	1.71789164
20	MP0002876_abnormal_thyroid_physiology	1.71468764
21	MP0004885_abnormal_endolymph	1.66802051
22	MP0008872_abnormal_physiological_respon	1.63525075
23	MP0002138_abnormal_hepatobiliary_system	1.62504995
24	MP0001835_abnormal_antigen_presentation	1.59145351
25	MP0003806_abnormal_nucleotide_metabolis	1.53335354
26	MP0002272_abnormal_nervous_system	1.52413295
27	MP0002163_abnormal_gland_morphology	1.51876840
28	MP0001984_abnormal_olfaction	1.48940604
29	MP0008789_abnormal_olfactory_epithelium	1.47050931
30	MP0001905_abnormal_dopamine_level	1.46676463
31	MP0001293_anophthalmia	1.45679270
32	MP0005379_endocrine/exocrine_gland_phen	1.45552234
33	MP0005084_abnormal_gallbladder_morpholo	1.44892602
34	MP0003195_calcinosis	1.42910449
35	MP0009745_abnormal_behavioral_response	1.41649209
36	MP0002837_dystrophic_cardiac_calcinosis	1.38974507
37	MP0002160_abnormal_reproductive_system	1.38252061
38	MP0003123_paternal_imprinting	1.38054709
39	MP0005253_abnormal_eye_physiology	1.36858837
40	MP0005389_reproductive_system_phenotype	1.36727444
41	MP0002736_abnormal_nociception_after	1.36460631
42	MP0001348_abnormal_lacrimal_gland	1.35616952
43	MP0003121_genomic_imprinting	1.33683211
44	MP0003880_abnormal_central_pattern	1.32112041
45	MP0001501_abnormal_sleep_pattern	1.28781107
46	MP0009764_decreased_sensitivity_to	1.28169746
47	MP0002938_white_spotting	1.25194584
48	MP0005377_hearing/vestibular/ear_phenot	1.23286407
49	MP0003878_abnormal_ear_physiology	1.23286407
50	MP0001485_abnormal_pinna_reflex	1.23054447
51	MP0001188_hyperpigmentation	1.22982461
52	MP0003122_maternal_imprinting	1.20486640
53	MP0000685_abnormal_immune_system	1.20198270
54	MP0008995_early_reproductive_senescence	1.19025489
55	MP0001970_abnormal_pain_threshold	1.16423256
56	MP0002733_abnormal_thermal_nociception	1.16360348
57	MP0003786_premature_aging	1.16053803
58	MP0003186_abnormal_redox_activity	1.15812552
59	MP0009046_muscle_twitch	1.15211981
60	MP0004742_abnormal_vestibular_system	1.13039578
61	MP0001440_abnormal_grooming_behavior	1.13022294
62	MP0000631_abnormal_neuroendocrine_gland	1.11813802
63	MP0003718_maternal_effect	1.10422847
64	MP0001919_abnormal_reproductive_system	1.10327703
65	MP0002557_abnormal_social/conspecific_i	1.08974975
66	MP0008775_abnormal_heart_ventricle	1.08937209
67	MP0008058_abnormal_DNA_repair	1.05200968
68	MP0003693_abnormal_embryo_hatching	1.03636879
69	MP0005394_taste/olfaction_phenotype	1.02907880
70	MP0005499_abnormal_olfactory_system	1.02907880
71	MP0002148_abnormal_hypersensitivity_rea	1.02814436
72	MP0004043_abnormal_pH_regulation	1.01749728
73	MP0005360_urolithiasis	1.00155476
74	MP0000427_abnormal_hair_cycle	0.99717800
75	MP0002735_abnormal_chemical_nociception	0.99707040
76	MP0004147_increased_porphyrin_level	0.99406871
77	MP0001529_abnormal_vocalization	0.98258308
78	MP0002653_abnormal_ependyma_morphology	0.96084120
79	MP0002572_abnormal_emotion/affect_behav	0.92097536
80	MP0001486_abnormal_startle_reflex	0.90997153
81	MP0003252_abnormal_bile_duct	0.90447490
82	MP0005195_abnormal_posterior_eye	0.88283923
83	MP0000049_abnormal_middle_ear	0.88113828
84	MP0000538_abnormal_urinary_bladder	0.88065389
85	MP0010386_abnormal_urinary_bladder	0.84769483
86	MP0002095_abnormal_skin_pigmentation	0.84444752
87	MP0002638_abnormal_pupillary_reflex	0.83004325
88	MP0001800_abnormal_humoral_immune	0.78218290
89	MP0002210_abnormal_sex_determination	0.76808642
90	MP0006036_abnormal_mitochondrial_physio	0.76256867
91	MP0002277_abnormal_respiratory_mucosa	0.75400295
92	MP0000955_abnormal_spinal_cord	0.74887073
93	MP0002734_abnormal_mechanical_nocicepti	0.74753756
94	MP0002752_abnormal_somatic_nervous	0.74178188
95	MP0001764_abnormal_homeostasis	0.73868915
96	MP0002064_seizures	0.71049468
97	MP0002184_abnormal_innervation	0.70582890
98	MP0004133_heterotaxia	0.69262939
99	MP0003635_abnormal_synaptic_transmissio	0.68063264
100	MP0002063_abnormal_learning/memory/cond	0.67894175

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.51510891
2	Acute necrotizing encephalopathy (HP:0006965)	4.24925757
3	3-Methylglutaconic aciduria (HP:0003535)	4.03747991
4	Mitochondrial inheritance (HP:0001427)	3.89172144
5	Acute encephalopathy (HP:0006846)	3.75742390
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.75418819
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.75234757
8	Abnormality of midbrain morphology (HP:0002418)	3.65481661
9	Molar tooth sign on MRI (HP:0002419)	3.65481661
10	Increased CSF lactate (HP:0002490)	3.47498967
11	Progressive macrocephaly (HP:0004481)	3.45827126
12	Macrocytic anemia (HP:0001972)	3.45048635
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.42047637
14	Hepatocellular necrosis (HP:0001404)	3.39320547
15	Pancreatic cysts (HP:0001737)	3.30819604
16	Abnormal number of erythroid precursors (HP:0012131)	3.17473356
17	Hepatic necrosis (HP:0002605)	3.17364049
18	Congenital stationary night blindness (HP:0007642)	2.98709668
19	Pancreatic fibrosis (HP:0100732)	2.98362522
20	Increased hepatocellular lipid droplets (HP:0006565)	2.97715976
21	Lipid accumulation in hepatocytes (HP:0006561)	2.91391349
22	Type II lissencephaly (HP:0007260)	2.90807386
23	Cerebral edema (HP:0002181)	2.88117428
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.82309468
25	Stomatitis (HP:0010280)	2.81916662
26	Abolished electroretinogram (ERG) (HP:0000550)	2.78851827
27	Nephronophthisis (HP:0000090)	2.73669049
28	Increased serum lactate (HP:0002151)	2.71448737
29	Optic disc pallor (HP:0000543)	2.64867903
30	Medial flaring of the eyebrow (HP:0010747)	2.62308908
31	Pallor (HP:0000980)	2.61374021
32	IgG deficiency (HP:0004315)	2.48959208
33	Lactic acidosis (HP:0003128)	2.45881202
34	Pendular nystagmus (HP:0012043)	2.44191368
35	True hermaphroditism (HP:0010459)	2.41553313
36	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.41260440
37	Decreased central vision (HP:0007663)	2.40928035
38	Asplenia (HP:0001746)	2.39377449
39	Renal Fanconi syndrome (HP:0001994)	2.37914010
40	Absent thumb (HP:0009777)	2.32170922
41	Retinal dysplasia (HP:0007973)	2.32135099
42	Elevated erythrocyte sedimentation rate (HP:0003565)	2.31860914
43	Aplastic anemia (HP:0001915)	2.31347067
44	Hyperalaninemia (HP:0003348)	2.30446099
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.30446099
46	Abnormality of alanine metabolism (HP:0010916)	2.30446099
47	Sclerocornea (HP:0000647)	2.28218720
48	Colon cancer (HP:0003003)	2.22702394
49	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.22246559
50	Abnormality of the renal medulla (HP:0100957)	2.20209594
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.20087187
52	Abnormal respiratory motile cilium morphology (HP:0005938)	2.20087187
53	Congenital, generalized hypertrichosis (HP:0004540)	2.18431312
54	Attenuation of retinal blood vessels (HP:0007843)	2.13555320
55	Abnormal hemoglobin (HP:0011902)	2.12482481
56	Increased intramyocellular lipid droplets (HP:0012240)	2.12221432
57	Abnormality of the renal cortex (HP:0011035)	2.09632089
58	Lethargy (HP:0001254)	2.07747133
59	Abnormal respiratory motile cilium physiology (HP:0012261)	2.06829896
60	Myokymia (HP:0002411)	2.06150323
61	Absent/shortened dynein arms (HP:0200106)	2.04719693
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.04719693
63	Respiratory failure (HP:0002878)	2.04102428
64	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.04063348
65	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03142493
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03142493
67	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.02653981
68	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.01792567
69	Abnormality of the labia minora (HP:0012880)	2.01224799
70	Agitation (HP:0000713)	2.00069734
71	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.99588542
72	Stomach cancer (HP:0012126)	1.97833952
73	Hyperglycinemia (HP:0002154)	1.96234679
74	Stenosis of the external auditory canal (HP:0000402)	1.95034760
75	Supernumerary spleens (HP:0009799)	1.93558637
76	Gait imbalance (HP:0002141)	1.92019335
77	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.91690045
78	Methylmalonic aciduria (HP:0012120)	1.90122474
79	Methylmalonic acidemia (HP:0002912)	1.90035953
80	Abnormal ciliary motility (HP:0012262)	1.87345051
81	Congenital primary aphakia (HP:0007707)	1.87325158
82	Increased muscle lipid content (HP:0009058)	1.86168716
83	Rib fusion (HP:0000902)	1.84478422
84	Abnormality of urine glucose concentration (HP:0011016)	1.82802960
85	Glycosuria (HP:0003076)	1.82802960
86	Severe combined immunodeficiency (HP:0004430)	1.82182261
87	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.78884336
88	Exertional dyspnea (HP:0002875)	1.78068847
89	Delayed CNS myelination (HP:0002188)	1.76296701
90	Exercise intolerance (HP:0003546)	1.75663727
91	Renal cortical cysts (HP:0000803)	1.74272854
92	Triphalangeal thumb (HP:0001199)	1.73669146
93	Abnormality of the middle phalanges of the toes (HP:0010183)	1.73154610
94	Nephrogenic diabetes insipidus (HP:0009806)	1.70581513
95	Cerebellar dysplasia (HP:0007033)	1.69346625
96	Metaphyseal dysplasia (HP:0100255)	1.68988379
97	Leukodystrophy (HP:0002415)	1.68964761
98	Hypoplasia of the radius (HP:0002984)	1.68155668
99	Pancytopenia (HP:0001876)	1.66735552
100	Confusion (HP:0001289)	1.65218753

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.59352752
2	STK16	3.54185881
3	TLK1	3.27069701
4	TAOK3	3.04024959
5	PINK1	2.83087644
6	NUAK1	2.72942594
7	ADRBK2	2.65429602
8	BCKDK	2.63982535
9	TXK	2.29647745
10	WNK4	2.27274001
11	DYRK2	2.02971155
12	GRK1	2.02830722
13	FRK	1.65609631
14	BMPR1B	1.51482453
15	VRK2	1.49178600
16	CDC7	1.31817860
17	FES	1.30640539
18	KIT	1.25816538
19	VRK1	1.25668099
20	TEC	1.22968590
21	NME2	1.20319742
22	ITK	1.19511049
23	IKBKB	1.15459026
24	WNK3	1.06465650
25	MAP4K1	1.05233399
26	SRPK1	1.04852845
27	PHKG1	1.04803593
28	PHKG2	1.04803593
29	MAP3K4	1.04484223
30	TRIM28	1.03776649
31	MAP4K2	0.99049917
32	INSRR	0.98585554
33	TIE1	0.96880006
34	RPS6KA5	0.95097614
35	DAPK2	0.94010229
36	CAMKK2	0.93246913
37	NME1	0.91983664
38	MAP2K2	0.88944733
39	PLK4	0.88511412
40	CDK19	0.88120036
41	EIF2AK1	0.87889061
42	MAP2K7	0.87882850
43	TAF1	0.87877798
44	LIMK1	0.85987587
45	MKNK1	0.85462708
46	MAP3K11	0.84505695
47	PIK3CA	0.83647619
48	EIF2AK3	0.83544122
49	KDR	0.82122699
50	BUB1	0.81697641
51	SYK	0.81474057
52	ADRBK1	0.80927282
53	AURKA	0.80437166
54	STK39	0.78637618
55	MST4	0.77038449
56	BTK	0.76224984
57	PLK3	0.75676053
58	OXSR1	0.72236700
59	IKBKE	0.69502074
60	MKNK2	0.68895391
61	PRKCG	0.67258902
62	CHEK2	0.65032178
63	PRKCQ	0.61873543
64	PAK3	0.61076996
65	PLK1	0.60828600
66	PLK2	0.58547805
67	GRK7	0.58494101
68	CSNK1G2	0.57340422
69	CAMK1	0.57123023
70	CSNK2A2	0.56643290
71	EIF2AK2	0.56016419
72	PDK2	0.55832668
73	LYN	0.54275525
74	CDK8	0.53014164
75	PRKACA	0.49153451
76	ATR	0.48869524
77	CASK	0.48569781
78	PIM2	0.47449892
79	CSNK1G3	0.47096543
80	ACVR1B	0.46851144
81	LRRK2	0.46827221
82	TNK2	0.45733906
83	LCK	0.45590076
84	OBSCN	0.44856952
85	NEK1	0.44489499
86	NTRK2	0.44454542
87	MATK	0.43713674
88	TYRO3	0.42554049
89	DAPK3	0.42356931
90	FLT3	0.42287369
91	PRKCD	0.41880247
92	CSNK2A1	0.40432015
93	MAP2K6	0.40284094
94	PRKCA	0.40237622
95	TGFBR1	0.39377995
96	MINK1	0.39215582
97	CSF1R	0.38866036
98	DAPK1	0.38849969
99	AURKB	0.38200612
100	PASK	0.37774475

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.41155456
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.97463721
3	Parkinsons disease_Homo sapiens_hsa05012	3.33972506
4	Proteasome_Homo sapiens_hsa03050	2.65607882
5	RNA polymerase_Homo sapiens_hsa03020	2.50537749
6	Asthma_Homo sapiens_hsa05310	2.46597645
7	Protein export_Homo sapiens_hsa03060	2.21305900
8	Huntingtons disease_Homo sapiens_hsa05016	2.21032461
9	Alzheimers disease_Homo sapiens_hsa05010	2.16317299
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.08385227
11	Caffeine metabolism_Homo sapiens_hsa00232	2.04980037
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.98878657
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.93362701
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.91091500
15	Allograft rejection_Homo sapiens_hsa05330	1.77623023
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.71488041
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.66561308
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.66266658
19	Homologous recombination_Homo sapiens_hsa03440	1.62102847
20	RNA degradation_Homo sapiens_hsa03018	1.57214697
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55383383
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.53170654
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52626842
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.39162646
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.36309673
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.31143085
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.30544492
28	Phototransduction_Homo sapiens_hsa04744	1.27333002
29	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26476768
30	One carbon pool by folate_Homo sapiens_hsa00670	1.24284143
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19840105
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.17898943
33	Propanoate metabolism_Homo sapiens_hsa00640	1.16995446
34	Peroxisome_Homo sapiens_hsa04146	1.16891435
35	Mismatch repair_Homo sapiens_hsa03430	1.09673387
36	Purine metabolism_Homo sapiens_hsa00230	1.08591421
37	Sulfur relay system_Homo sapiens_hsa04122	1.06837914
38	Nicotine addiction_Homo sapiens_hsa05033	1.04373912
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03727304
40	Basal transcription factors_Homo sapiens_hsa03022	1.03356073
41	DNA replication_Homo sapiens_hsa03030	0.98898592
42	Base excision repair_Homo sapiens_hsa03410	0.97389692
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96847388
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96793379
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95402900
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93327156
47	Butanoate metabolism_Homo sapiens_hsa00650	0.92894013
48	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.92409353
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.90097734
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.89587572
51	Spliceosome_Homo sapiens_hsa03040	0.89201444
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87615144
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.86945993
54	RNA transport_Homo sapiens_hsa03013	0.86057379
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86038659
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.85035100
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.81968048
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81423374
59	Sulfur metabolism_Homo sapiens_hsa00920	0.81066579
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.78660148
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77023986
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.76809398
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.73144558
64	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72773052
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.71630347
66	Metabolic pathways_Homo sapiens_hsa01100	0.68169138
67	Regulation of autophagy_Homo sapiens_hsa04140	0.66508929
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65926137
69	Olfactory transduction_Homo sapiens_hsa04740	0.63878463
70	Fatty acid elongation_Homo sapiens_hsa00062	0.61511968
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59787646
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56928484
73	Morphine addiction_Homo sapiens_hsa05032	0.55210689
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53968272
75	Retinol metabolism_Homo sapiens_hsa00830	0.53670714
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53418001
77	Salivary secretion_Homo sapiens_hsa04970	0.50839088
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.49584281
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49059489
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45829313
81	Serotonergic synapse_Homo sapiens_hsa04726	0.45078098
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40905307
83	Taste transduction_Homo sapiens_hsa04742	0.39788305
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.37593538
85	Insulin secretion_Homo sapiens_hsa04911	0.37371470
86	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37267785
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.36471272
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35326296
89	Non-homologous end-joining_Homo sapiens_hsa03450	0.33788110
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.32715870
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.31768744
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.30059794
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.28718793
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27111669
95	Folate biosynthesis_Homo sapiens_hsa00790	0.26324141
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.25361293
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.23641681
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.23391785
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.22775150
100	GABAergic synapse_Homo sapiens_hsa04727	0.22374584

RPS4XP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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