ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	7.10137044
2	ribosomal small subunit assembly (GO:0000028)	6.58053622
3	viral transcription (GO:0019083)	6.41899628
4	ribosomal small subunit biogenesis (GO:0042274)	6.24790343
5	translational termination (GO:0006415)	6.13896044
6	behavioral response to nicotine (GO:0035095)	5.79849355
7	chaperone-mediated protein transport (GO:0072321)	5.58057359
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.56633110
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.23191606
10	translational elongation (GO:0006414)	5.20097573
11	cotranslational protein targeting to membrane (GO:0006613)	5.14017895
12	protein targeting to ER (GO:0045047)	5.13984324
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.92128043
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.87608412
15	ATP synthesis coupled proton transport (GO:0015986)	4.87608412
16	protein localization to endoplasmic reticulum (GO:0070972)	4.82309373
17	DNA deamination (GO:0045006)	4.71968447
18	viral life cycle (GO:0019058)	4.69015873
19	cellular protein complex disassembly (GO:0043624)	4.53071846
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.45458521
21	GTP biosynthetic process (GO:0006183)	4.30724459
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.20871716
23	NADH dehydrogenase complex assembly (GO:0010257)	4.20871716
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.20871716
25	protein neddylation (GO:0045116)	4.18718045
26	translational initiation (GO:0006413)	4.17272390
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.15628010
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.14318194
29	ribosomal large subunit biogenesis (GO:0042273)	3.91500003
30	protein complex biogenesis (GO:0070271)	3.90566705
31	protein complex disassembly (GO:0043241)	3.85124558
32	ribonucleoprotein complex biogenesis (GO:0022613)	3.76307427
33	macromolecular complex disassembly (GO:0032984)	3.72433601
34	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.67608290
35	cellular component biogenesis (GO:0044085)	3.66952987
36	UTP biosynthetic process (GO:0006228)	3.66520853
37	rRNA catabolic process (GO:0016075)	3.64304054
38	UTP metabolic process (GO:0046051)	3.63165029
39	translation (GO:0006412)	3.56039920
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.52201861
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.51385527
42	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.48701099
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.48701099
44	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.48260009
45	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.44454830
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.43673952
47	protein targeting to membrane (GO:0006612)	3.42333246
48	cell proliferation in forebrain (GO:0021846)	3.30317609
49	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.28996346
50	electron transport chain (GO:0022900)	3.28946450
51	mRNA catabolic process (GO:0006402)	3.26869486
52	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.25952182
53	piRNA metabolic process (GO:0034587)	3.25777076
54	respiratory electron transport chain (GO:0022904)	3.24012223
55	nonmotile primary cilium assembly (GO:0035058)	3.23160233
56	peptidyl-histidine modification (GO:0018202)	3.22205687
57	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.19766773
58	rRNA processing (GO:0006364)	3.13912537
59	intracellular protein transmembrane import (GO:0044743)	3.13787216
60	epithelial cilium movement (GO:0003351)	3.13361731
61	rRNA metabolic process (GO:0016072)	3.10752132
62	positive regulation of T cell apoptotic process (GO:0070234)	3.09883970
63	pyrimidine nucleotide catabolic process (GO:0006244)	3.09625372
64	pattern specification involved in kidney development (GO:0061004)	3.06072636
65	ubiquinone biosynthetic process (GO:0006744)	3.02036880
66	water-soluble vitamin biosynthetic process (GO:0042364)	2.98742319
67	ATP biosynthetic process (GO:0006754)	2.96871679
68	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.94499300
69	RNA catabolic process (GO:0006401)	2.93333443
70	hydrogen ion transmembrane transport (GO:1902600)	2.92244931
71	maturation of 5.8S rRNA (GO:0000460)	2.92186763
72	negative regulation of telomere maintenance (GO:0032205)	2.89721601
73	ribosome biogenesis (GO:0042254)	2.87434377
74	synaptic transmission, cholinergic (GO:0007271)	2.84942405
75	replication fork processing (GO:0031297)	2.83438825
76	somite development (GO:0061053)	2.79898281
77	amine catabolic process (GO:0009310)	2.77308975
78	cellular biogenic amine catabolic process (GO:0042402)	2.77308975
79	proton transport (GO:0015992)	2.76081346
80	pyrimidine nucleobase catabolic process (GO:0006208)	2.75043466
81	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.73781159
82	cardiovascular system development (GO:0072358)	2.70680711
83	pseudouridine synthesis (GO:0001522)	2.70273640
84	response to xenobiotic stimulus (GO:0009410)	2.69997352
85	regulation of cilium movement (GO:0003352)	2.69730882
86	hydrogen transport (GO:0006818)	2.68571750
87	otic vesicle formation (GO:0030916)	2.66674516
88	protein-cofactor linkage (GO:0018065)	2.66230341
89	ubiquinone metabolic process (GO:0006743)	2.65035008
90	head development (GO:0060322)	2.62961602
91	CTP biosynthetic process (GO:0006241)	2.62031972
92	CTP metabolic process (GO:0046036)	2.62031972
93	negative regulation of T cell differentiation in thymus (GO:0033085)	2.61413273
94	resolution of meiotic recombination intermediates (GO:0000712)	2.58609025
95	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.57443973
96	axonemal dynein complex assembly (GO:0070286)	2.57172324
97	kynurenine metabolic process (GO:0070189)	2.57137888
98	guanosine-containing compound biosynthetic process (GO:1901070)	2.53047621
99	intracellular protein transmembrane transport (GO:0065002)	2.51581008
100	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.50891750

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.45636061
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.58111409
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.34084065
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.17686853
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.86917209
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.85710250
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.74796105
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.73076943
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.46621648
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30135406
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.29364631
12	VDR_22108803_ChIP-Seq_LS180_Human	1.93412267
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.91960847
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73330808
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.72143852
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71971713
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.66836885
18	TTF2_22483619_ChIP-Seq_HELA_Human	1.66629080
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.65307399
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.61746662
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61435894
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60161485
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59896699
24	EWS_26573619_Chip-Seq_HEK293_Human	1.59497794
25	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.58589481
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.58542124
27	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.53097973
28	RNF2_27304074_Chip-Seq_NSC_Mouse	1.50068901
29	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.49470777
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.47958658
31	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45495635
32	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.44960796
33	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.41896676
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.41694664
35	FUS_26573619_Chip-Seq_HEK293_Human	1.39412999
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38882832
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38473269
38	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.35390149
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35267533
40	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.34722202
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33966664
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33090616
43	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.30976691
44	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.29838256
45	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.29834285
46	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.27774116
47	ELK1_19687146_ChIP-ChIP_HELA_Human	1.27461445
48	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.26307752
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25484912
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.25097546
51	GABP_19822575_ChIP-Seq_HepG2_Human	1.23537102
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.22100266
53	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22035239
54	ERA_21632823_ChIP-Seq_H3396_Human	1.21380771
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19989642
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19989642
57	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.19969052
58	P53_21459846_ChIP-Seq_SAOS-2_Human	1.19167758
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.19145855
60	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.15223003
61	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.14585333
62	NCOR_22424771_ChIP-Seq_293T_Human	1.13433353
63	P300_19829295_ChIP-Seq_ESCs_Human	1.13283020
64	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.13225226
65	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.12466023
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11245325
67	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11043147
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10919331
69	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.08323222
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07637362
71	IGF1R_20145208_ChIP-Seq_DFB_Human	1.06873234
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05525749
73	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.04595032
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04011269
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04011269
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03325249
77	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.03314990
78	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.02831779
79	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02473178
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02284739
81	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.01668434
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01627217
83	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.00771522
84	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.00484898
85	XRN2_22483619_ChIP-Seq_HELA_Human	0.99682465
86	MYC_19829295_ChIP-Seq_ESCs_Human	0.99467436
87	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.99449127
88	TAF15_26573619_Chip-Seq_HEK293_Human	0.99314577
89	AR_20517297_ChIP-Seq_VCAP_Human	0.99041172
90	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.96380051
91	ER_23166858_ChIP-Seq_MCF-7_Human	0.96339096
92	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.94561763
93	BCAT_22108803_ChIP-Seq_LS180_Human	0.91701779
94	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.91143349
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90683764
96	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.89324830
97	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.88525268
98	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.88232186
99	IRF1_19129219_ChIP-ChIP_H3396_Human	0.88197697
100	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.88150153

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.25419624
2	MP0006292_abnormal_olfactory_placode	3.90227122
3	MP0003787_abnormal_imprinting	3.67568513
4	MP0008877_abnormal_DNA_methylation	3.36602352
5	MP0003122_maternal_imprinting	3.24175600
6	MP0004142_abnormal_muscle_tone	2.74497631
7	MP0003121_genomic_imprinting	2.63755431
8	MP0001485_abnormal_pinna_reflex	2.13564490
9	MP0002653_abnormal_ependyma_morphology	2.10943035
10	MP0001968_abnormal_touch/_nociception	1.97544091
11	MP0004742_abnormal_vestibular_system	1.93011157
12	MP0004885_abnormal_endolymph	1.88779453
13	MP0006276_abnormal_autonomic_nervous	1.85167273
14	MP0006072_abnormal_retinal_apoptosis	1.85122005
15	MP0003878_abnormal_ear_physiology	1.77582281
16	MP0005377_hearing/vestibular/ear_phenot	1.77582281
17	MP0002837_dystrophic_cardiac_calcinosis	1.76900140
18	MP0002272_abnormal_nervous_system	1.74481806
19	MP0004145_abnormal_muscle_electrophysio	1.73144841
20	MP0003136_yellow_coat_color	1.71960572
21	MP0008789_abnormal_olfactory_epithelium	1.70939124
22	MP0002277_abnormal_respiratory_mucosa	1.70160011
23	MP0002736_abnormal_nociception_after	1.69249993
24	MP0003646_muscle_fatigue	1.67305900
25	MP0005551_abnormal_eye_electrophysiolog	1.64675450
26	MP0001293_anophthalmia	1.63342454
27	MP0001986_abnormal_taste_sensitivity	1.60952464
28	MP0002163_abnormal_gland_morphology	1.56611978
29	MP0002638_abnormal_pupillary_reflex	1.55926976
30	MP0002102_abnormal_ear_morphology	1.54201927
31	MP0008875_abnormal_xenobiotic_pharmacok	1.52287640
32	MP0002138_abnormal_hepatobiliary_system	1.49917510
33	MP0005394_taste/olfaction_phenotype	1.43070359
34	MP0005499_abnormal_olfactory_system	1.43070359
35	MP0009745_abnormal_behavioral_response	1.41907848
36	MP0003123_paternal_imprinting	1.41136827
37	MP0002876_abnormal_thyroid_physiology	1.41083517
38	MP0000049_abnormal_middle_ear	1.40484322
39	MP0005423_abnormal_somatic_nervous	1.40315425
40	MP0001970_abnormal_pain_threshold	1.39823082
41	MP0005645_abnormal_hypothalamus_physiol	1.37537465
42	MP0000778_abnormal_nervous_system	1.36790849
43	MP0001440_abnormal_grooming_behavior	1.36403635
44	MP0000631_abnormal_neuroendocrine_gland	1.34298030
45	MP0002733_abnormal_thermal_nociception	1.30972999
46	MP0005646_abnormal_pituitary_gland	1.30667488
47	MP0004133_heterotaxia	1.27823595
48	MP0008872_abnormal_physiological_respon	1.27576830
49	MP0003186_abnormal_redox_activity	1.27338263
50	MP0005253_abnormal_eye_physiology	1.27239543
51	MP0009046_muscle_twitch	1.25355629
52	MP0002735_abnormal_chemical_nociception	1.21315068
53	MP0002557_abnormal_social/conspecific_i	1.18447163
54	MP0000955_abnormal_spinal_cord	1.17999313
55	MP0002234_abnormal_pharynx_morphology	1.17947573
56	MP0001984_abnormal_olfaction	1.15638098
57	MP0002572_abnormal_emotion/affect_behav	1.14713827
58	MP0001529_abnormal_vocalization	1.14711452
59	MP0004147_increased_porphyrin_level	1.14699624
60	MP0001486_abnormal_startle_reflex	1.11981225
61	MP0002938_white_spotting	1.11177017
62	MP0002184_abnormal_innervation	1.09533860
63	MP0002063_abnormal_learning/memory/cond	1.09090778
64	MP0002752_abnormal_somatic_nervous	1.07769191
65	MP0002160_abnormal_reproductive_system	1.06473887
66	MP0003635_abnormal_synaptic_transmissio	1.06349093
67	MP0000566_synostosis	1.06082931
68	MP0002734_abnormal_mechanical_nocicepti	1.06007410
69	MP0005195_abnormal_posterior_eye	1.05621880
70	MP0000427_abnormal_hair_cycle	1.03661939
71	MP0000026_abnormal_inner_ear	1.03535497
72	MP0005389_reproductive_system_phenotype	1.03517206
73	MP0001963_abnormal_hearing_physiology	1.02274164
74	MP0002067_abnormal_sensory_capabilities	0.99394359
75	MP0003011_delayed_dark_adaptation	0.92291172
76	MP0005084_abnormal_gallbladder_morpholo	0.90506316
77	MP0003195_calcinosis	0.89699456
78	MP0005174_abnormal_tail_pigmentation	0.86689736
79	MP0002064_seizures	0.86372508
80	MP0001905_abnormal_dopamine_level	0.85305624
81	MP0005379_endocrine/exocrine_gland_phen	0.84840307
82	MP0003718_maternal_effect	0.81287761
83	MP0001919_abnormal_reproductive_system	0.81192605
84	MP0002095_abnormal_skin_pigmentation	0.80735596
85	MP0005083_abnormal_biliary_tract	0.80605782
86	MP0003936_abnormal_reproductive_system	0.76575891
87	MP0002210_abnormal_sex_determination	0.76421656
88	MP0003879_abnormal_hair_cell	0.76280409
89	MP0002229_neurodegeneration	0.75641182
90	MP0004043_abnormal_pH_regulation	0.74780893
91	MP0008058_abnormal_DNA_repair	0.73926003
92	MP0008775_abnormal_heart_ventricle	0.73772862
93	MP0003786_premature_aging	0.73678454
94	MP0002882_abnormal_neuron_morphology	0.73652753
95	MP0003938_abnormal_ear_development	0.72728517
96	MP0003937_abnormal_limbs/digits/tail_de	0.72655664
97	MP0005391_vision/eye_phenotype	0.72005881
98	MP0001835_abnormal_antigen_presentation	0.71691909
99	MP0009764_decreased_sensitivity_to	0.67122658
100	MP0002233_abnormal_nose_morphology	0.66634596

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.47637472
2	Acute necrotizing encephalopathy (HP:0006965)	4.30203253
3	Molar tooth sign on MRI (HP:0002419)	4.19633434
4	Abnormality of midbrain morphology (HP:0002418)	4.19633434
5	Pancreatic fibrosis (HP:0100732)	3.98895738
6	Pancreatic cysts (HP:0001737)	3.68716030
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.67813845
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.66397450
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.57503197
10	Acute encephalopathy (HP:0006846)	3.55561933
11	Progressive macrocephaly (HP:0004481)	3.47046943
12	Abnormality of the labia minora (HP:0012880)	3.46089175
13	True hermaphroditism (HP:0010459)	3.41684354
14	Type II lissencephaly (HP:0007260)	3.32277997
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.21639361
16	Nephronophthisis (HP:0000090)	3.13480708
17	Congenital stationary night blindness (HP:0007642)	3.12955981
18	Mitochondrial inheritance (HP:0001427)	3.11442855
19	Macrocytic anemia (HP:0001972)	3.11406998
20	Pendular nystagmus (HP:0012043)	2.93444919
21	Asplenia (HP:0001746)	2.87995706
22	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.87656430
23	Partial duplication of thumb phalanx (HP:0009944)	2.84725289
24	Increased CSF lactate (HP:0002490)	2.80632869
25	Optic disc pallor (HP:0000543)	2.74128636
26	Abnormality of the renal medulla (HP:0100957)	2.67434194
27	Stenosis of the external auditory canal (HP:0000402)	2.63764680
28	Cystic liver disease (HP:0006706)	2.63542108
29	Cerebral edema (HP:0002181)	2.60852714
30	Supernumerary spleens (HP:0009799)	2.60567125
31	Abnormal number of erythroid precursors (HP:0012131)	2.55569304
32	Anencephaly (HP:0002323)	2.55033528
33	Absent/shortened dynein arms (HP:0200106)	2.53467221
34	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.53467221
35	Bile duct proliferation (HP:0001408)	2.50394779
36	Abnormal biliary tract physiology (HP:0012439)	2.50394779
37	3-Methylglutaconic aciduria (HP:0003535)	2.50192431
38	Septo-optic dysplasia (HP:0100842)	2.47589696
39	Pallor (HP:0000980)	2.47052256
40	Medial flaring of the eyebrow (HP:0010747)	2.41422006
41	Partial duplication of the phalanx of hand (HP:0009999)	2.40919612
42	Colon cancer (HP:0003003)	2.38666625
43	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.37400958
44	Abnormality of DNA repair (HP:0003254)	2.31043184
45	Chronic hepatic failure (HP:0100626)	2.29618130
46	Abnormal respiratory motile cilium morphology (HP:0005938)	2.28252517
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.28252517
48	Oligodactyly (hands) (HP:0001180)	2.25788964
49	Abnormal drinking behavior (HP:0030082)	2.23493736
50	Polydipsia (HP:0001959)	2.23493736
51	Absent thumb (HP:0009777)	2.23474543
52	Sclerocornea (HP:0000647)	2.22455021
53	Myokymia (HP:0002411)	2.21410953
54	Adrenal hypoplasia (HP:0000835)	2.19895213
55	Lissencephaly (HP:0001339)	2.17586036
56	Abolished electroretinogram (ERG) (HP:0000550)	2.16745556
57	Abnormality of the renal cortex (HP:0011035)	2.13197719
58	Postaxial foot polydactyly (HP:0001830)	2.12652826
59	Abnormal hemoglobin (HP:0011902)	2.12445389
60	Hepatocellular necrosis (HP:0001404)	2.10644603
61	Cerebellar dysplasia (HP:0007033)	2.09672325
62	Congenital, generalized hypertrichosis (HP:0004540)	2.07893627
63	Rib fusion (HP:0000902)	2.03416653
64	Agitation (HP:0000713)	2.01454285
65	Gait imbalance (HP:0002141)	1.99931114
66	Congenital hepatic fibrosis (HP:0002612)	1.97806705
67	Decreased central vision (HP:0007663)	1.97050877
68	Polyuria (HP:0000103)	1.96190432
69	Hyperglycinemia (HP:0002154)	1.94758601
70	Hypoplasia of the radius (HP:0002984)	1.94213055
71	Male pseudohermaphroditism (HP:0000037)	1.93476343
72	11 pairs of ribs (HP:0000878)	1.92763927
73	Depressed nasal ridge (HP:0000457)	1.92265020
74	Leukodystrophy (HP:0002415)	1.90680966
75	Pachygyria (HP:0001302)	1.84001381
76	Holoprosencephaly (HP:0001360)	1.83820478
77	Polyphagia (HP:0002591)	1.82550095
78	Hepatic necrosis (HP:0002605)	1.82500757
79	Increased serum lactate (HP:0002151)	1.81648065
80	Stomatitis (HP:0010280)	1.81281200
81	Congenital primary aphakia (HP:0007707)	1.77371374
82	Lethargy (HP:0001254)	1.76635913
83	Microretrognathia (HP:0000308)	1.76372332
84	Failure to thrive in infancy (HP:0001531)	1.76137070
85	Anophthalmia (HP:0000528)	1.75968040
86	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.73552059
87	Dandy-Walker malformation (HP:0001305)	1.73111733
88	Hypoplasia of the pons (HP:0012110)	1.72734307
89	Tubular atrophy (HP:0000092)	1.72567241
90	Hypoplasia of the ulna (HP:0003022)	1.71734696
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.70551276
92	Optic nerve hypoplasia (HP:0000609)	1.69579260
93	Nephrogenic diabetes insipidus (HP:0009806)	1.64862782
94	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.63764258
95	Triphalangeal thumb (HP:0001199)	1.63634315
96	Abnormal ciliary motility (HP:0012262)	1.63311805
97	Abnormal respiratory motile cilium physiology (HP:0012261)	1.63177460
98	Narrow forehead (HP:0000341)	1.62920763
99	Duplication of thumb phalanx (HP:0009942)	1.62111337
100	Lactic acidosis (HP:0003128)	1.61186066

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.78128386
2	WNK4	3.49084005
3	PINK1	3.34215413
4	TXK	2.77464547
5	NUAK1	2.77321824
6	WNK3	2.72659685
7	TLK1	2.59709144
8	ADRBK2	2.48788680
9	DYRK2	2.48239275
10	MAP4K2	2.45375349
11	TAF1	2.38249138
12	ZAK	2.33354403
13	STK39	2.32366484
14	FRK	2.18445600
15	GRK1	1.84748093
16	TAOK3	1.81249967
17	NME2	1.77482052
18	NME1	1.76020688
19	PHKG2	1.50324437
20	PHKG1	1.50324437
21	OXSR1	1.47025720
22	TIE1	1.46420316
23	VRK2	1.43345846
24	CDK19	1.34240787
25	EPHB2	1.33809382
26	BCKDK	1.25705462
27	PIK3CA	1.25127370
28	SIK2	1.22199587
29	LRRK2	1.16694937
30	CAMK1	1.16475219
31	CAMK1D	1.15594352
32	CASK	1.06489835
33	EIF2AK3	1.01485910
34	BMPR1B	0.96208403
35	TNIK	0.94784559
36	WNK1	0.93589372
37	MAP3K11	0.93455714
38	TRIM28	0.91773114
39	CDC7	0.85847752
40	PDK2	0.84504288
41	ADRBK1	0.84240144
42	LIMK1	0.82738531
43	MARK1	0.82692904
44	MAPK13	0.82140923
45	TEC	0.78882130
46	VRK1	0.77160877
47	NTRK2	0.75980722
48	PRKCG	0.75723375
49	GRK7	0.73396950
50	PRKCI	0.72227838
51	MINK1	0.71041885
52	NEK2	0.70235194
53	MAPKAPK5	0.69151895
54	PLK2	0.68212233
55	MKNK2	0.67449154
56	TYRO3	0.65090477
57	INSRR	0.64891919
58	CAMK1G	0.63752210
59	MAP2K7	0.63380103
60	CAMKK2	0.62083195
61	PRKCZ	0.61180000
62	FGFR2	0.59951176
63	AURKA	0.59873655
64	CAMK4	0.59177079
65	KIT	0.58784711
66	CSNK1G2	0.57113822
67	PRKD3	0.55973694
68	PRKACA	0.55392704
69	NEK1	0.53632604
70	PRKCQ	0.53470248
71	PAK3	0.52041974
72	PLK1	0.51297438
73	ITK	0.51155733
74	PLK3	0.50599960
75	EIF2AK2	0.49857786
76	AURKB	0.49662694
77	CSNK1E	0.49361059
78	GRK5	0.48725255
79	IKBKB	0.48591361
80	CSNK2A2	0.48403619
81	CHEK2	0.46530144
82	STK11	0.45907422
83	ABL2	0.45335687
84	CSNK1G3	0.44819728
85	CSNK1A1L	0.44116384
86	DAPK3	0.44101246
87	RPS6KA5	0.42136997
88	MKNK1	0.42085536
89	OBSCN	0.41975372
90	BTK	0.40828596
91	DYRK3	0.40584724
92	SGK1	0.38490904
93	CSNK1G1	0.36595339
94	MST4	0.34377985
95	PRKCA	0.34292955
96	PNCK	0.34058719
97	IKBKE	0.31347829
98	SYK	0.30227654
99	CAMK2A	0.30182100
100	PRKG1	0.29930971

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.56967088
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.90005296
3	Parkinsons disease_Homo sapiens_hsa05012	3.24385407
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.96383061
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.54207373
6	Huntingtons disease_Homo sapiens_hsa05016	2.26757177
7	RNA polymerase_Homo sapiens_hsa03020	2.21019650
8	Alzheimers disease_Homo sapiens_hsa05010	2.19231113
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.16030550
10	Protein export_Homo sapiens_hsa03060	2.15184632
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.13199089
12	Proteasome_Homo sapiens_hsa03050	2.04902700
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.04446763
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.96467132
15	RNA degradation_Homo sapiens_hsa03018	1.91079957
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80446836
17	Asthma_Homo sapiens_hsa05310	1.63001594
18	Phototransduction_Homo sapiens_hsa04744	1.62706032
19	Basal transcription factors_Homo sapiens_hsa03022	1.61923389
20	Homologous recombination_Homo sapiens_hsa03440	1.58147955
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.57102769
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.53135592
23	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44121861
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.42876638
25	One carbon pool by folate_Homo sapiens_hsa00670	1.40940428
26	Nicotine addiction_Homo sapiens_hsa05033	1.31722408
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.29512987
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28103702
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26093331
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23918125
31	Butanoate metabolism_Homo sapiens_hsa00650	1.22910841
32	Peroxisome_Homo sapiens_hsa04146	1.16115435
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.14435824
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.12125999
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.12071150
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.12029476
37	Propanoate metabolism_Homo sapiens_hsa00640	1.09364780
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09152059
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06374258
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.03959777
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03641047
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98012107
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.96781495
44	Allograft rejection_Homo sapiens_hsa05330	0.91446297
45	Morphine addiction_Homo sapiens_hsa05032	0.91006547
46	Sulfur relay system_Homo sapiens_hsa04122	0.89232534
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.86392839
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84533664
49	Purine metabolism_Homo sapiens_hsa00230	0.83137698
50	Olfactory transduction_Homo sapiens_hsa04740	0.81750074
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81265141
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81184640
53	Insulin secretion_Homo sapiens_hsa04911	0.76258188
54	Primary immunodeficiency_Homo sapiens_hsa05340	0.74488848
55	Caffeine metabolism_Homo sapiens_hsa00232	0.70890711
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70384590
57	DNA replication_Homo sapiens_hsa03030	0.70369268
58	Mismatch repair_Homo sapiens_hsa03430	0.69765493
59	Metabolic pathways_Homo sapiens_hsa01100	0.69213949
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66577889
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.65501783
62	RNA transport_Homo sapiens_hsa03013	0.65475773
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64781754
64	Spliceosome_Homo sapiens_hsa03040	0.64548096
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64164279
66	Graft-versus-host disease_Homo sapiens_hsa05332	0.62414556
67	Glutamatergic synapse_Homo sapiens_hsa04724	0.59722799
68	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.59482949
69	Type I diabetes mellitus_Homo sapiens_hsa04940	0.58800000
70	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.58063009
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56259773
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55360567
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53133587
74	GABAergic synapse_Homo sapiens_hsa04727	0.52371636
75	Serotonergic synapse_Homo sapiens_hsa04726	0.51750730
76	Retinol metabolism_Homo sapiens_hsa00830	0.51562252
77	Folate biosynthesis_Homo sapiens_hsa00790	0.50663040
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49613746
79	Taste transduction_Homo sapiens_hsa04742	0.44175533
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43515487
81	Base excision repair_Homo sapiens_hsa03410	0.43283660
82	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.42584287
83	Fatty acid degradation_Homo sapiens_hsa00071	0.39914656
84	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.39632643
85	Rheumatoid arthritis_Homo sapiens_hsa05323	0.38731447
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37708589
87	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37489593
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37056168
89	Salivary secretion_Homo sapiens_hsa04970	0.35262987
90	Glutathione metabolism_Homo sapiens_hsa00480	0.34478837
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.33125798
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.31654553
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.29595378
94	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.28152293
95	Circadian entrainment_Homo sapiens_hsa04713	0.26349540
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.25750082
97	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.25455742
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.25337107
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.23136183
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.22863373

RPS4XP20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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