ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA methylation involved in gamete generation (GO:0043046)	8.28342452
2	lipopolysaccharide biosynthetic process (GO:0009103)	7.97394122
3	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	7.83999866
4	regulation of meiosis I (GO:0060631)	7.11973145
5	protein-chromophore linkage (GO:0018298)	7.09632838
6	lipopolysaccharide metabolic process (GO:0008653)	6.92656460
7	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	6.65895385
8	piRNA metabolic process (GO:0034587)	6.55391971
9	sulfate transmembrane transport (GO:1902358)	6.24996558
10	negative regulation of cell cycle G2/M phase transition (GO:1902750)	5.73891668
11	regulation of protein glycosylation (GO:0060049)	5.70911357
12	heme transport (GO:0015886)	5.35199733
13	positive regulation of developmental pigmentation (GO:0048087)	5.24836226
14	regulation of pigment cell differentiation (GO:0050932)	5.23731951
15	DNA deamination (GO:0045006)	5.18485220
16	sulfate transport (GO:0008272)	5.16879032
17	negative regulation of glycoprotein biosynthetic process (GO:0010561)	5.10576632
18	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	4.99579559
19	ribonucleoprotein complex disassembly (GO:0032988)	4.83074697
20	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.58875001
21	L-phenylalanine catabolic process (GO:0006559)	4.58875001
22	paraxial mesoderm development (GO:0048339)	4.48593296
23	organelle disassembly (GO:1903008)	4.40735166
24	positive regulation of meiosis (GO:0045836)	4.25976979
25	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.20618423
26	centriole replication (GO:0007099)	4.17605334
27	negative regulation of stem cell proliferation (GO:2000647)	4.14815513
28	tyrosine metabolic process (GO:0006570)	4.06686207
29	meiotic chromosome segregation (GO:0045132)	4.03420372
30	iron coordination entity transport (GO:1901678)	4.00290028
31	positive regulation of meiotic cell cycle (GO:0051446)	3.94686954
32	SMAD protein complex assembly (GO:0007183)	3.93597932
33	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.92979327
34	L-phenylalanine metabolic process (GO:0006558)	3.92979327
35	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.88207879
36	negative regulation of glycoprotein metabolic process (GO:1903019)	3.87783866
37	notochord development (GO:0030903)	3.84890113
38	serotonin receptor signaling pathway (GO:0007210)	3.74784358
39	glycerol metabolic process (GO:0006071)	3.72782681
40	aromatic amino acid family catabolic process (GO:0009074)	3.54241860
41	rhodopsin mediated signaling pathway (GO:0016056)	3.49876577
42	response to muscle activity (GO:0014850)	3.47329425
43	alditol metabolic process (GO:0019400)	3.47272175
44	biotin metabolic process (GO:0006768)	3.43724942
45	response to gravity (GO:0009629)	3.42897880
46	sympathetic nervous system development (GO:0048485)	3.41572348
47	flavonoid metabolic process (GO:0009812)	3.38973897
48	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.32591030
49	regulation of odontogenesis (GO:0042481)	3.28805862
50	response to mercury ion (GO:0046689)	3.23355564
51	cellular response to gamma radiation (GO:0071480)	3.15180407
52	toxin metabolic process (GO:0009404)	3.06025044
53	aromatic amino acid family metabolic process (GO:0009072)	3.03794978
54	positive regulation of fatty acid oxidation (GO:0046321)	3.00756855
55	regulation of interleukin-5 production (GO:0032674)	3.00659455
56	tachykinin receptor signaling pathway (GO:0007217)	3.00226478
57	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	2.99683803
58	nodal signaling pathway (GO:0038092)	2.97971678
59	DNA alkylation (GO:0006305)	2.97425206
60	DNA methylation (GO:0006306)	2.97425206
61	uterus development (GO:0060065)	2.96485332
62	organ induction (GO:0001759)	2.95441190
63	indolalkylamine metabolic process (GO:0006586)	2.95233919
64	behavioral response to nicotine (GO:0035095)	2.94919109
65	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.94436491
66	sulfur compound transport (GO:0072348)	2.91390338
67	regulation of transforming growth factor beta2 production (GO:0032909)	2.90567143
68	negative regulation of neural precursor cell proliferation (GO:2000178)	2.83994291
69	maturation of SSU-rRNA (GO:0030490)	2.81169018
70	embryonic skeletal joint morphogenesis (GO:0060272)	2.80300202
71	protein retention in ER lumen (GO:0006621)	2.79648449
72	germinal center formation (GO:0002467)	2.73407496
73	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.72345617
74	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71096781
75	ribosomal small subunit biogenesis (GO:0042274)	2.70158685
76	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	2.69324022
77	pantothenate metabolic process (GO:0015939)	2.66425265
78	regulation of cellular respiration (GO:0043457)	2.66251350
79	mannosylation (GO:0097502)	2.65474471
80	centriole assembly (GO:0098534)	2.64565999
81	DNA modification (GO:0006304)	2.62410767
82	DNA methylation or demethylation (GO:0044728)	2.61646530
83	tryptophan catabolic process (GO:0006569)	2.61234624
84	indole-containing compound catabolic process (GO:0042436)	2.61234624
85	indolalkylamine catabolic process (GO:0046218)	2.61234624
86	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.59313467
87	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.59313467
88	DNA damage induced protein phosphorylation (GO:0006975)	2.58205604
89	kynurenine metabolic process (GO:0070189)	2.57956211
90	vitamin transmembrane transport (GO:0035461)	2.56674848
91	translational termination (GO:0006415)	2.55395224
92	regulation of translational termination (GO:0006449)	2.55086288
93	response to epinephrine (GO:0071871)	2.54716242
94	positive regulation of SMAD protein import into nucleus (GO:0060391)	2.52304738
95	cofactor transport (GO:0051181)	2.50027640
96	peptidyl-histidine modification (GO:0018202)	2.49149078
97	adaptation of signaling pathway (GO:0023058)	2.47766395
98	sphingosine metabolic process (GO:0006670)	13.6185345
99	diol metabolic process (GO:0034311)	12.5965060
100	sphingoid metabolic process (GO:0046519)	11.3426007

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.37141591
2	AR_21572438_ChIP-Seq_LNCaP_Human	4.14142882
3	IGF1R_20145208_ChIP-Seq_DFB_Human	4.08420455
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.99007125
5	VDR_22108803_ChIP-Seq_LS180_Human	2.98469031
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.65735799
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.52592473
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.51502468
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.27346795
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26839450
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.17317021
12	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.10003139
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99615049
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.87085451
15	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85608420
16	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.84163456
17	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.84118488
18	STAT1_20625510_ChIP-Seq_HELA_Human	1.83814050
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.83024631
20	P300_19829295_ChIP-Seq_ESCs_Human	1.81864624
21	HOXB7_26014856_ChIP-Seq_BT474_Human	1.80547803
22	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.72861393
23	NANOG_19829295_ChIP-Seq_ESCs_Human	1.71216113
24	SOX2_19829295_ChIP-Seq_ESCs_Human	1.71216113
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.70110241
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68893602
27	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.67057636
28	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.55436587
29	NCOR_22424771_ChIP-Seq_293T_Human	1.52025477
30	EGR1_19032775_ChIP-ChIP_M12_Human	1.51482374
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50121264
32	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50121264
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.48642713
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47901482
35	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.46630277
36	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.45539473
37	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.45226584
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.43417723
39	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.41671295
40	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.41196121
41	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.38364380
42	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.38301507
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38076573
44	OCT4_20526341_ChIP-Seq_ESCs_Human	1.36257912
45	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.35809654
46	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.34219671
47	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.31093971
48	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.28441631
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25547639
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25547639
51	RAC3_21632823_ChIP-Seq_H3396_Human	1.23307369
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22622481
53	TCF4_23295773_ChIP-Seq_U87_Human	1.21866430
54	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20039924
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.19115111
56	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.18202618
57	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18161882
58	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17495060
59	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16790303
60	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15448345
61	P53_21459846_ChIP-Seq_SAOS-2_Human	1.15331337
62	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.14789241
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14569623
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.11487534
65	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.11334141
66	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10501147
67	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.10179332
68	CEBPB_22108803_ChIP-Seq_LS180_Human	1.07048044
69	FUS_26573619_Chip-Seq_HEK293_Human	1.06100719
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04012168
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02952053
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01810245
73	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.01358131
74	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00594249
75	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.00436675
76	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.00061185
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99826895
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99560364
79	AR_20517297_ChIP-Seq_VCAP_Human	0.98615413
80	STAT3_23295773_ChIP-Seq_U87_Human	0.97380456
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96593866
82	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.96468776
83	AR_25329375_ChIP-Seq_VCAP_Human	0.96439834
84	TCF4_22108803_ChIP-Seq_LS180_Human	0.96107638
85	SPI1_20517297_ChIP-Seq_HL60_Human	0.95897706
86	STAT3_18555785_ChIP-Seq_MESCs_Mouse	0.95751167
87	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95673610
88	E2F1_20622854_ChIP-Seq_HELA_Human	0.95334515
89	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.95309622
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.95102682
91	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.94976752
92	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.94957482
93	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.94328515
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.90409519
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89395999
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.89395999
97	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.89168491
98	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.88831773
99	ERA_21632823_ChIP-Seq_H3396_Human	0.88024145
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.87855515

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	9.03393896
2	MP0003136_yellow_coat_color	6.93265228
3	MP0005171_absent_coat_pigmentation	6.40167014
4	MP0002653_abnormal_ependyma_morphology	6.23249431
5	MP0003646_muscle_fatigue	4.63486386
6	MP0003045_fibrosis	4.18060692
7	MP0003890_abnormal_embryonic-extraembry	3.63346551
8	MP0003879_abnormal_hair_cell	3.32177879
9	MP0000749_muscle_degeneration	2.47515490
10	MP0004381_abnormal_hair_follicle	2.45554204
11	MP0002138_abnormal_hepatobiliary_system	2.41703667
12	MP0004147_increased_porphyrin_level	2.15624273
13	MP0005085_abnormal_gallbladder_physiolo	2.09088034
14	MP0005670_abnormal_white_adipose	2.07012586
15	MP0002938_white_spotting	1.91742906
16	MP0005075_abnormal_melanosome_morpholog	1.87988748
17	MP0000569_abnormal_digit_pigmentation	1.86200836
18	MP0002160_abnormal_reproductive_system	1.60832414
19	MP0005365_abnormal_bile_salt	1.55620013
20	MP0002168_other_aberrant_phenotype	1.54836811
21	MP0003195_calcinosis	1.54033250
22	MP0004145_abnormal_muscle_electrophysio	1.47041678
23	MP0002095_abnormal_skin_pigmentation	1.42804473
24	MP0003705_abnormal_hypodermis_morpholog	1.41481065
25	MP0002269_muscular_atrophy	1.34124088
26	MP0000427_abnormal_hair_cycle	1.29925832
27	MP0004142_abnormal_muscle_tone	1.26401942
28	MP0008872_abnormal_physiological_respon	1.06583236
29	MP0002735_abnormal_chemical_nociception	1.06117188
30	MP0004043_abnormal_pH_regulation	1.06111995
31	MP0000372_irregular_coat_pigmentation	1.01881492
32	MP0008875_abnormal_xenobiotic_pharmacok	0.96983172
33	MP0003137_abnormal_impulse_conducting	0.95276784
34	MP0005395_other_phenotype	0.93345529
35	MP0006276_abnormal_autonomic_nervous	0.90300483
36	MP0002075_abnormal_coat/hair_pigmentati	0.88787214
37	MP0000534_abnormal_ureter_morphology	0.88461201
38	MP0005389_reproductive_system_phenotype	0.87639211
39	MP0005330_cardiomyopathy	0.85481314
40	MP0002272_abnormal_nervous_system	0.82746246
41	MP0009745_abnormal_behavioral_response	0.79094261
42	MP0001970_abnormal_pain_threshold	0.78682629
43	MP0002277_abnormal_respiratory_mucosa	0.76914668
44	MP0001984_abnormal_olfaction	0.73772257
45	MP0005646_abnormal_pituitary_gland	0.73080503
46	MP0001501_abnormal_sleep_pattern	0.72451850
47	MP0001968_abnormal_touch/_nociception	0.71462062
48	MP0003878_abnormal_ear_physiology	0.69207300
49	MP0005377_hearing/vestibular/ear_phenot	0.69207300
50	MP0009764_decreased_sensitivity_to	0.69206457
51	MP0002876_abnormal_thyroid_physiology	0.68628330
52	MP0001486_abnormal_startle_reflex	0.68339293
53	MP0002733_abnormal_thermal_nociception	0.68323598
54	MP0005174_abnormal_tail_pigmentation	0.67188412
55	MP0002332_abnormal_exercise_endurance	0.66941761
56	MP0009379_abnormal_foot_pigmentation	0.66075379
57	MP0004233_abnormal_muscle_weight	0.64892386
58	MP0008770_decreased_survivor_rate	0.64629216
59	MP0002106_abnormal_muscle_physiology	0.64514207
60	MP0001661_extended_life_span	0.64363281
61	MP0005319_abnormal_enzyme/_coenzyme	0.63592933
62	MP0005551_abnormal_eye_electrophysiolog	0.61469789
63	MP0003959_abnormal_lean_body	0.61074030
64	MP0001186_pigmentation_phenotype	0.60121438
65	MP0004130_abnormal_muscle_cell	0.58964453
66	MP0001986_abnormal_taste_sensitivity	0.57781653
67	MP0003937_abnormal_limbs/digits/tail_de	0.57716832
68	MP0009046_muscle_twitch	0.55372787
69	MP0005620_abnormal_muscle_contractility	0.53822342
70	MP0002163_abnormal_gland_morphology	0.53360578
71	MP0004484_altered_response_of	0.52569582
72	MP0002736_abnormal_nociception_after	0.51995939
73	MP0003123_paternal_imprinting	0.50677320
74	MP0006292_abnormal_olfactory_placode	0.49660086
75	MP0003942_abnormal_urinary_system	0.49483474
76	MP0000759_abnormal_skeletal_muscle	0.49114895
77	MP0000747_muscle_weakness	0.49034285
78	MP0001963_abnormal_hearing_physiology	0.49032468
79	MP0002184_abnormal_innervation	0.48952319
80	MP0004858_abnormal_nervous_system	0.48809765
81	MP0003252_abnormal_bile_duct	0.48389428
82	MP0005410_abnormal_fertilization	0.47137973
83	MP0002229_neurodegeneration	0.46551071
84	MP0006072_abnormal_retinal_apoptosis	0.46502819
85	MP0006036_abnormal_mitochondrial_physio	0.46130506
86	MP0002210_abnormal_sex_determination	0.46035795
87	MP0006054_spinal_hemorrhage	0.46009775
88	MP0000026_abnormal_inner_ear	0.44733707
89	MP0002752_abnormal_somatic_nervous	0.43314874
90	MP0002572_abnormal_emotion/affect_behav	0.43196882
91	MP0001905_abnormal_dopamine_level	0.42866401
92	MP0001800_abnormal_humoral_immune	0.42367292
93	MP0003950_abnormal_plasma_membrane	0.41652347
94	MP0005369_muscle_phenotype	0.40825137
95	MP0002064_seizures	0.39376250
96	MP0000470_abnormal_stomach_morphology	0.39050272
97	MP0005266_abnormal_metabolism	0.38693136
98	MP0002102_abnormal_ear_morphology	0.37588436
99	MP0008775_abnormal_heart_ventricle	0.37321410
100	MP0008569_lethality_at_weaning	0.37277689

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	8.07879608
2	Focal motor seizures (HP:0011153)	7.51689732
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	6.63787797
4	Parakeratosis (HP:0001036)	6.24321700
5	Acanthocytosis (HP:0001927)	4.88142376
6	Aplastic anemia (HP:0001915)	4.78728311
7	Pancreatic cysts (HP:0001737)	4.33735425
8	Colon cancer (HP:0003003)	4.32408115
9	Congenital ichthyosiform erythroderma (HP:0007431)	4.02118055
10	Dialeptic seizures (HP:0011146)	3.85772682
11	Rectal prolapse (HP:0002035)	3.82203327
12	Proximal amyotrophy (HP:0007126)	3.66092973
13	Erythroderma (HP:0001019)	3.62170887
14	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.55843876
15	Pendular nystagmus (HP:0012043)	3.54636794
16	Radial bowing (HP:0002986)	3.42554431
17	Cerebellar dysplasia (HP:0007033)	3.21583477
18	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.19401710
19	Focal seizures (HP:0007359)	3.13584490
20	Type II lissencephaly (HP:0007260)	3.07339982
21	Hematochezia (HP:0002573)	3.04556244
22	Abnormality of the renal cortex (HP:0011035)	2.97750498
23	Decreased circulating renin level (HP:0003351)	2.89380860
24	Reticulocytopenia (HP:0001896)	2.74697515
25	Scapular winging (HP:0003691)	2.65585378
26	Congenital stationary night blindness (HP:0007642)	2.60828980
27	Abnormality of the renal medulla (HP:0100957)	2.53068355
28	Difficulty walking (HP:0002355)	2.52909581
29	Facial shape deformation (HP:0011334)	2.52425225
30	Potter facies (HP:0002009)	2.52425225
31	Synostosis of carpal bones (HP:0005048)	2.49999269
32	Pancreatic fibrosis (HP:0100732)	2.47715197
33	Abnormality of macular pigmentation (HP:0008002)	2.46957271
34	Nephronophthisis (HP:0000090)	2.45306075
35	Ulnar claw (HP:0001178)	2.44555601
36	3-Methylglutaconic aciduria (HP:0003535)	2.44109603
37	Abnormality of midbrain morphology (HP:0002418)	2.43715081
38	Molar tooth sign on MRI (HP:0002419)	2.43715081
39	Cystic liver disease (HP:0006706)	2.43616696
40	Palpebral edema (HP:0100540)	2.43128754
41	Enlarged kidneys (HP:0000105)	2.39680530
42	Tarsal synostosis (HP:0008368)	2.35250202
43	Poikilocytosis (HP:0004447)	2.30729323
44	Overlapping toe (HP:0001845)	2.28894168
45	Spontaneous hematomas (HP:0007420)	2.20453004
46	Synostosis involving bones of the feet (HP:0009140)	2.20384384
47	Synostosis involving bones of the lower limbs (HP:0009138)	2.20384384
48	Hypokalemia (HP:0002900)	2.18898184
49	Hyperkalemia (HP:0002153)	2.15352651
50	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.15214214
51	Abnormality of potassium homeostasis (HP:0011042)	2.14984475
52	Nonprogressive disorder (HP:0003680)	2.10905197
53	Opisthotonus (HP:0002179)	2.08795755
54	Severe visual impairment (HP:0001141)	2.06453704
55	Large for gestational age (HP:0001520)	2.05302000
56	Vertebral arch anomaly (HP:0008438)	2.03620560
57	Hypoplastic iliac wings (HP:0002866)	2.00499420
58	IgM deficiency (HP:0002850)	1.99176186
59	Abnormality of the vocal cords (HP:0008777)	1.98517858
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96530151
61	Absent/shortened dynein arms (HP:0200106)	1.96530151
62	Retinitis pigmentosa (HP:0000510)	1.95533699
63	Abolished electroretinogram (ERG) (HP:0000550)	1.95138510
64	Abnormality of cells of the erythroid lineage (HP:0012130)	1.94824633
65	Pancytopenia (HP:0001876)	1.94297275
66	Anencephaly (HP:0002323)	1.92604076
67	Abnormal albumin level (HP:0012116)	1.89226177
68	Hypoalbuminemia (HP:0003073)	1.89226177
69	Tubular atrophy (HP:0000092)	1.88808977
70	Acute necrotizing encephalopathy (HP:0006965)	1.88795959
71	Hepatic necrosis (HP:0002605)	1.87908268
72	Type I transferrin isoform profile (HP:0003642)	1.87037736
73	Petechiae (HP:0000967)	1.86557567
74	Mitochondrial inheritance (HP:0001427)	1.86011658
75	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.85097382
76	Bilateral sensorineural hearing impairment (HP:0008619)	1.84109783
77	Congenital, generalized hypertrichosis (HP:0004540)	1.83881670
78	Polydipsia (HP:0001959)	1.83520042
79	Abnormal drinking behavior (HP:0030082)	1.83520042
80	Increased CSF lactate (HP:0002490)	1.83064963
81	Increased corneal curvature (HP:0100692)	1.83010608
82	Keratoconus (HP:0000563)	1.83010608
83	Abnormal rod and cone electroretinograms (HP:0008323)	1.82255865
84	Hepatocellular necrosis (HP:0001404)	1.82124967
85	Inability to walk (HP:0002540)	1.81070462
86	True hermaphroditism (HP:0010459)	1.79491388
87	Abnormal ciliary motility (HP:0012262)	1.78888819
88	Esophageal varix (HP:0002040)	1.78152232
89	Bowing of the arm (HP:0006488)	1.77923547
90	Bowed forearm bones (HP:0003956)	1.77923547
91	Hypoplasia of the pons (HP:0012110)	1.76643690
92	Congenital hepatic fibrosis (HP:0002612)	1.75855474
93	Acute encephalopathy (HP:0006846)	1.72193516
94	Palpitations (HP:0001962)	1.71716368
95	Progressive inability to walk (HP:0002505)	1.70128138
96	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.69724687
97	Increased serum lactate (HP:0002151)	1.68556839
98	Conjunctival telangiectasia (HP:0000524)	1.68365847
99	2-3 toe syndactyly (HP:0004691)	1.67522171
100	Macular degeneration (HP:0000608)	1.67329132

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	9.78322358
2	STK38L	6.83010140
3	LATS2	5.72676995
4	PRKD3	3.31218396
5	FRK	3.07905138
6	ZAK	3.03573294
7	STK38	2.63748683
8	MAP2K2	2.49089227
9	ACVR1B	2.38787287
10	NLK	1.99468092
11	BMPR1B	1.97244175
12	STK3	1.84742119
13	WNK4	1.71435135
14	NEK2	1.60392101
15	MELK	1.46449727
16	EIF2AK3	1.41433452
17	STK16	1.40322551
18	VRK2	1.15095832
19	PHKG1	1.09297580
20	PHKG2	1.09297580
21	TAF1	1.05485406
22	PINK1	1.03189100
23	ADRBK2	0.99578899
24	PRKAA2	0.93726400
25	NME2	0.92005410
26	PIK3CG	0.91544749
27	PDPK1	0.83398165
28	GRK7	0.81387449
29	NUAK1	0.80586621
30	STK39	0.77613882
31	MUSK	0.76701327
32	DAPK2	0.74701412
33	TGFBR1	0.72209957
34	CSNK1A1L	0.69726071
35	GRK5	0.66405555
36	MOS	0.64762419
37	ADRBK1	0.62446667
38	GRK1	0.62028146
39	OXSR1	0.55167940
40	TIE1	0.54219703
41	MAP3K2	0.50745097
42	IRAK3	0.49625149
43	SCYL2	0.46380878
44	PRKD1	0.45675590
45	TXK	0.45607713
46	MAPKAPK3	0.45530135
47	TAOK3	0.44764745
48	TRIM28	0.44613179
49	TLK1	0.44410648
50	LIMK1	0.41846372
51	CDK19	0.40954980
52	TEC	0.39667561
53	OBSCN	0.39469901
54	WNK3	0.38507533
55	PRKCI	0.37834820
56	KSR2	0.36472548
57	ITK	0.34198534
58	NME1	0.32960043
59	DAPK1	0.32061411
60	CHEK2	0.30989032
61	TNK2	0.30943586
62	STK11	0.28016128
63	PIM1	0.27110501
64	WNK1	0.26408362
65	TGFBR2	0.24234464
66	EIF2AK2	0.21679874
67	PLK1	0.20476129
68	PBK	0.20392655
69	CSF1R	0.18993883
70	PRKACA	0.18630045
71	VRK1	0.18548619
72	NEK1	0.17505185
73	BRAF	0.16466350
74	PRKCE	0.16309093
75	BTK	0.15791146
76	MAP2K1	0.15614186
77	MAP4K2	0.14780987
78	DYRK2	0.14429466
79	CSNK1D	0.13880739
80	MAPKAPK5	0.13104547
81	MAPK13	0.12323937
82	PLK2	0.12111789
83	EPHB2	0.11741494
84	PLK3	0.11583490
85	AURKA	0.11516819
86	DAPK3	0.10868595
87	PRKCG	0.10200567
88	INSRR	0.08793244
89	TTK	0.08124713
90	PTK2B	0.07928600
91	ABL1	0.07643251
92	PRKG2	0.06833453
93	NEK9	0.06402985
94	CAMK1	0.05403685
95	RPS6KA5	0.04294820
96	IKBKB	0.04030070
97	CSNK1G2	0.03331290
98	EIF2AK1	0.02942722
99	KIT	0.02884407
100	CSNK1A1	0.02357449

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	7.05694817
2	Phototransduction_Homo sapiens_hsa04744	4.39918959
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.11422799
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.94442236
5	Sphingolipid metabolism_Homo sapiens_hsa00600	2.77499915
6	Ribosome_Homo sapiens_hsa03010	2.74903835
7	Nicotine addiction_Homo sapiens_hsa05033	2.58242126
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.49041685
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.16316173
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.99309009
11	Asthma_Homo sapiens_hsa05310	1.80246202
12	Taste transduction_Homo sapiens_hsa04742	1.77293847
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.76432225
14	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.73182113
15	Morphine addiction_Homo sapiens_hsa05032	1.70783577
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.55572920
17	Parkinsons disease_Homo sapiens_hsa05012	1.54323406
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54250162
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.43006787
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.39758748
21	One carbon pool by folate_Homo sapiens_hsa00670	1.38641450
22	Phenylalanine metabolism_Homo sapiens_hsa00360	1.35511745
23	Viral myocarditis_Homo sapiens_hsa05416	1.34111212
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.28316993
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.27481190
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.26431237
27	Huntingtons disease_Homo sapiens_hsa05016	1.26059625
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22385562
29	GABAergic synapse_Homo sapiens_hsa04727	1.16798907
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.15032554
31	Alzheimers disease_Homo sapiens_hsa05010	1.14436027
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.14067882
33	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.13462992
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.10202765
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08809943
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.07990032
37	Basal transcription factors_Homo sapiens_hsa03022	1.05940801
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04511610
39	Sulfur relay system_Homo sapiens_hsa04122	1.03282471
40	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.02020016
41	Proteasome_Homo sapiens_hsa03050	0.98015441
42	Allograft rejection_Homo sapiens_hsa05330	0.93167177
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87591808
44	RNA degradation_Homo sapiens_hsa03018	0.86890341
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86426072
46	Homologous recombination_Homo sapiens_hsa03440	0.85206373
47	Folate biosynthesis_Homo sapiens_hsa00790	0.84248156
48	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.83886760
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82460007
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74635200
51	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.73510705
52	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.72819227
53	Serotonergic synapse_Homo sapiens_hsa04726	0.69705906
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.68414404
55	Salivary secretion_Homo sapiens_hsa04970	0.68186674
56	Collecting duct acid secretion_Homo sapiens_hsa04966	0.66314339
57	RNA polymerase_Homo sapiens_hsa03020	0.63938145
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63663113
59	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62399990
60	Tyrosine metabolism_Homo sapiens_hsa00350	0.61824172
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.55861815
62	Metabolic pathways_Homo sapiens_hsa01100	0.53467366
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53249416
64	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.52176906
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.51822838
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.51306764
67	Olfactory transduction_Homo sapiens_hsa04740	0.47357857
68	Butanoate metabolism_Homo sapiens_hsa00650	0.45856332
69	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.45757149
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43741362
71	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.42477460
72	VEGF signaling pathway_Homo sapiens_hsa04370	0.41482362
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40983136
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40081412
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.39433567
76	Purine metabolism_Homo sapiens_hsa00230	0.38028916
77	Histidine metabolism_Homo sapiens_hsa00340	0.37915623
78	Peroxisome_Homo sapiens_hsa04146	0.36855263
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.36447531
80	Retinol metabolism_Homo sapiens_hsa00830	0.34277867
81	Rheumatoid arthritis_Homo sapiens_hsa05323	0.34161285
82	Insulin secretion_Homo sapiens_hsa04911	0.33645268
83	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33543166
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.30168597
85	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.30134607
86	Graft-versus-host disease_Homo sapiens_hsa05332	0.29930146
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29272005
88	Propanoate metabolism_Homo sapiens_hsa00640	0.28831303
89	ABC transporters_Homo sapiens_hsa02010	0.27442075
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27325076
91	Glutathione metabolism_Homo sapiens_hsa00480	0.25825958
92	Bile secretion_Homo sapiens_hsa04976	0.25610573
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25285562
94	Thyroid cancer_Homo sapiens_hsa05216	0.24343010
95	Circadian entrainment_Homo sapiens_hsa04713	0.23942673
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.23671262
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22997880
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.22231372
99	Fatty acid degradation_Homo sapiens_hsa00071	0.21111550
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.20203794

RPS4XP21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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