ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.96420718
2	viral transcription (GO:0019083)	6.94277942
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.74883711
4	ATP synthesis coupled proton transport (GO:0015986)	6.74883711
5	translational termination (GO:0006415)	6.66398008
6	ribosomal small subunit assembly (GO:0000028)	6.64665904
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.08986592
8	cotranslational protein targeting to membrane (GO:0006613)	5.97513271
9	protein targeting to ER (GO:0045047)	5.96387979
10	translational elongation (GO:0006414)	5.79744471
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.69006754
12	protein localization to endoplasmic reticulum (GO:0070972)	5.66535409
13	maturation of SSU-rRNA (GO:0030490)	5.57957780
14	ribosomal large subunit biogenesis (GO:0042273)	5.52872160
15	ribosomal small subunit biogenesis (GO:0042274)	5.34930344
16	viral life cycle (GO:0019058)	4.98169689
17	cellular protein complex disassembly (GO:0043624)	4.94353313
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.83090854
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.80362423
20	translational initiation (GO:0006413)	4.75003465
21	respiratory electron transport chain (GO:0022904)	4.68292793
22	electron transport chain (GO:0022900)	4.60937675
23	DNA deamination (GO:0045006)	4.46953170
24	protein complex biogenesis (GO:0070271)	4.42096542
25	translation (GO:0006412)	4.28582156
26	mitochondrial respiratory chain complex assembly (GO:0033108)	4.17889959
27	NADH dehydrogenase complex assembly (GO:0010257)	4.02576138
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.02576138
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.02576138
30	protein complex disassembly (GO:0043241)	4.01943750
31	protein targeting to membrane (GO:0006612)	3.91666860
32	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.90937315
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.90937315
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.90428145
35	macromolecular complex disassembly (GO:0032984)	3.83583716
36	chaperone-mediated protein transport (GO:0072321)	3.81601712
37	proteasome assembly (GO:0043248)	3.80092872
38	protein neddylation (GO:0045116)	3.78818149
39	ATP biosynthetic process (GO:0006754)	3.69113298
40	cullin deneddylation (GO:0010388)	3.63876842
41	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.62931646
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.61607153
43	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.60453451
44	protein deneddylation (GO:0000338)	3.53923312
45	hydrogen ion transmembrane transport (GO:1902600)	3.52745722
46	termination of RNA polymerase III transcription (GO:0006386)	3.50607105
47	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.50607105
48	cellular component biogenesis (GO:0044085)	3.43608824
49	mRNA catabolic process (GO:0006402)	3.42565675
50	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.41150806
51	GTP biosynthetic process (GO:0006183)	3.33030600
52	ribonucleoprotein complex biogenesis (GO:0022613)	3.32065410
53	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29580249
54	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.29273876
55	respiratory chain complex IV assembly (GO:0008535)	3.28981756
56	oxidative phosphorylation (GO:0006119)	3.26224576
57	proton transport (GO:0015992)	3.24527548
58	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.23733467
59	rRNA modification (GO:0000154)	3.20984858
60	hydrogen transport (GO:0006818)	3.19927906
61	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.13226766
62	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.12540604
63	RNA catabolic process (GO:0006401)	3.11026773
64	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.09237581
65	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.07229561
66	rRNA processing (GO:0006364)	3.02604003
67	rRNA metabolic process (GO:0016072)	2.98692930
68	cytochrome complex assembly (GO:0017004)	2.97830143
69	pseudouridine synthesis (GO:0001522)	2.94819002
70	protein-cofactor linkage (GO:0018065)	2.92243501
71	UTP biosynthetic process (GO:0006228)	2.83286160
72	base-excision repair, AP site formation (GO:0006285)	2.77041386
73	positive regulation of defense response to virus by host (GO:0002230)	2.75666460
74	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.74806083
75	nucleoside triphosphate biosynthetic process (GO:0009142)	2.73500535
76	regulation of mitochondrial translation (GO:0070129)	2.73344285
77	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.72773780
78	mannosylation (GO:0097502)	2.71521093
79	negative regulation of T cell differentiation in thymus (GO:0033085)	2.69752073
80	UTP metabolic process (GO:0046051)	2.69202619
81	positive regulation of activated T cell proliferation (GO:0042104)	2.67710220
82	GPI anchor biosynthetic process (GO:0006506)	2.67079395
83	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.62313309
84	cytidine deamination (GO:0009972)	2.60751510
85	cytidine metabolic process (GO:0046087)	2.60751510
86	cytidine catabolic process (GO:0006216)	2.60751510
87	response to interferon-beta (GO:0035456)	2.60397436
88	establishment of protein localization to membrane (GO:0090150)	2.59698039
89	preassembly of GPI anchor in ER membrane (GO:0016254)	2.59569230
90	regulation of memory T cell differentiation (GO:0043380)	2.59397935
91	regulation of chronic inflammatory response (GO:0002676)	2.56593446
92	GPI anchor metabolic process (GO:0006505)	2.55929589
93	protein targeting (GO:0006605)	2.55510264
94	S-adenosylmethionine metabolic process (GO:0046500)	2.55214929
95	inner mitochondrial membrane organization (GO:0007007)	2.54837556
96	guanosine-containing compound biosynthetic process (GO:1901070)	2.51338978
97	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.49434373
98	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.49434373
99	sleep (GO:0030431)	2.49343238
100	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.47900348

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.70060856
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.30695304
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.22866365
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.85116221
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.27711353
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.17064782
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.12711230
8	VDR_23849224_ChIP-Seq_CD4+_Human	3.05222255
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.02490355
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.00385764
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.94789851
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.47192692
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.46980928
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.45166617
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.42957059
16	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.38918354
17	VDR_22108803_ChIP-Seq_LS180_Human	2.34824643
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.24481965
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.20598935
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.15184230
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.03358065
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.02464239
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.97392340
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.92309713
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.91426977
26	TTF2_22483619_ChIP-Seq_HELA_Human	1.90251535
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.87895551
28	ZNF274_21170338_ChIP-Seq_K562_Hela	1.85158029
29	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.65122753
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.60710866
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.60580443
32	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.57754708
33	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.53545077
34	DCP1A_22483619_ChIP-Seq_HELA_Human	1.51475742
35	XRN2_22483619_ChIP-Seq_HELA_Human	1.50797304
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50656312
37	EWS_26573619_Chip-Seq_HEK293_Human	1.50293727
38	FUS_26573619_Chip-Seq_HEK293_Human	1.50189991
39	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.49710017
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46440027
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46440027
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.45832704
43	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.44865053
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.43494112
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41680325
46	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.40333713
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.40275563
48	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.40083528
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.39359212
50	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.39301741
51	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.38123304
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.37811862
53	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.36164151
54	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.35968820
55	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.35919721
56	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.33812726
57	AR_20517297_ChIP-Seq_VCAP_Human	1.31892670
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.31654561
59	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.31038198
60	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.28812554
61	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.27595861
62	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.26018165
63	GATA3_26560356_Chip-Seq_TH2_Human	1.24420916
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.23627476
65	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.23023952
66	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.19048678
67	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17909168
68	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.17216433
69	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17208259
70	MYB_26560356_Chip-Seq_TH2_Human	1.14151860
71	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.13038500
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12544948
73	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.06729999
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06678882
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06678882
76	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06640552
77	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.05745144
78	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.05057491
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03536228
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03180546
81	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02747811
82	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02341756
83	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01668762
84	ERG_20517297_ChIP-Seq_VCAP_Human	1.01241541
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00654860
86	NCOR_22424771_ChIP-Seq_293T_Human	0.98265184
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97806787
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96294055
89	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.96127301
90	SPI1_23547873_ChIP-Seq_NB4_Human	0.95867955
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93251527
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93085677
93	IRF1_19129219_ChIP-ChIP_H3396_Human	0.92012950
94	RUNX_20019798_ChIP-Seq_JUKART_Human	0.91061788
95	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90943736
96	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.90837137
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.90307052
98	ER_23166858_ChIP-Seq_MCF-7_Human	0.88221970
99	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.88173475
100	TAF15_26573619_Chip-Seq_HEK293_Human	0.86950775

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.96036436
2	MP0003806_abnormal_nucleotide_metabolis	3.63925324
3	MP0001835_abnormal_antigen_presentation	3.62280320
4	MP0005671_abnormal_response_to	3.53490942
5	MP0003646_muscle_fatigue	2.60841744
6	MP0006072_abnormal_retinal_apoptosis	2.55393085
7	MP0002876_abnormal_thyroid_physiology	2.53222841
8	MP0003011_delayed_dark_adaptation	2.40406621
9	MP0008875_abnormal_xenobiotic_pharmacok	2.29173924
10	MP0002837_dystrophic_cardiac_calcinosis	2.13650962
11	MP0000685_abnormal_immune_system	2.10165765
12	MP0009785_altered_susceptibility_to	2.01262490
13	MP0004147_increased_porphyrin_level	2.00871382
14	MP0002148_abnormal_hypersensitivity_rea	1.98710377
15	MP0005646_abnormal_pituitary_gland	1.94337709
16	MP0001800_abnormal_humoral_immune	1.87554349
17	MP0003763_abnormal_thymus_physiology	1.86302774
18	MP0004145_abnormal_muscle_electrophysio	1.85247785
19	MP0005000_abnormal_immune_tolerance	1.81819920
20	MP0003186_abnormal_redox_activity	1.71929789
21	MP0001986_abnormal_taste_sensitivity	1.70472473
22	MP0005360_urolithiasis	1.68771897
23	MP0001873_stomach_inflammation	1.64924086
24	MP0003786_premature_aging	1.61782968
25	MP0006036_abnormal_mitochondrial_physio	1.60008620
26	MP0008872_abnormal_physiological_respon	1.58945157
27	MP0005387_immune_system_phenotype	1.57266230
28	MP0001790_abnormal_immune_system	1.57266230
29	MP0002102_abnormal_ear_morphology	1.54580215
30	MP0005503_abnormal_tendon_morphology	1.53805879
31	MP0004142_abnormal_muscle_tone	1.51951234
32	MP0002723_abnormal_immune_serum	1.51632444
33	MP0004885_abnormal_endolymph	1.48784669
34	MP0002452_abnormal_antigen_presenting	1.46346869
35	MP0003195_calcinosis	1.43974118
36	MP0009333_abnormal_splenocyte_physiolog	1.41518480
37	MP0002166_altered_tumor_susceptibility	1.40895808
38	MP0000372_irregular_coat_pigmentation	1.39391377
39	MP0008995_early_reproductive_senescence	1.36907424
40	MP0003436_decreased_susceptibility_to	1.35748164
41	MP0001819_abnormal_immune_cell	1.34709643
42	MP0005075_abnormal_melanosome_morpholog	1.33486966
43	MP0003724_increased_susceptibility_to	1.33461774
44	MP0002420_abnormal_adaptive_immunity	1.30941553
45	MP0002006_tumorigenesis	1.30096430
46	MP0005551_abnormal_eye_electrophysiolog	1.29658654
47	MP0009764_decreased_sensitivity_to	1.29602697
48	MP0002933_joint_inflammation	1.26308179
49	MP0005084_abnormal_gallbladder_morpholo	1.25640975
50	MP0008058_abnormal_DNA_repair	1.23881493
51	MP0002277_abnormal_respiratory_mucosa	1.23767688
52	MP0005253_abnormal_eye_physiology	1.22260630
53	MP0002163_abnormal_gland_morphology	1.21744139
54	MP0006292_abnormal_olfactory_placode	1.21432564
55	MP0003866_abnormal_defecation	1.20178595
56	MP0003718_maternal_effect	1.14134559
57	MP0005645_abnormal_hypothalamus_physiol	1.12165536
58	MP0005332_abnormal_amino_acid	1.11917781
59	MP0002160_abnormal_reproductive_system	1.10121397
60	MP0001764_abnormal_homeostasis	1.09224193
61	MP0005636_abnormal_mineral_homeostasis	1.06295587
62	MP0005389_reproductive_system_phenotype	1.05631188
63	MP0005025_abnormal_response_to	1.03942847
64	MP0010155_abnormal_intestine_physiology	1.02368958
65	MP0000716_abnormal_immune_system	1.02176613
66	MP0001905_abnormal_dopamine_level	1.01496150
67	MP0006082_CNS_inflammation	1.00514474
68	MP0002736_abnormal_nociception_after	1.00111037
69	MP0002398_abnormal_bone_marrow	0.99845327
70	MP0001845_abnormal_inflammatory_respons	0.96408962
71	MP0001968_abnormal_touch/_nociception	0.96079031
72	MP0002938_white_spotting	0.94788625
73	MP0000689_abnormal_spleen_morphology	0.94618646
74	MP0001501_abnormal_sleep_pattern	0.93748378
75	MP0001542_abnormal_bone_strength	0.93287218
76	MP0008469_abnormal_protein_level	0.92976707
77	MP0003878_abnormal_ear_physiology	0.90510653
78	MP0005377_hearing/vestibular/ear_phenot	0.90510653
79	MP0002405_respiratory_system_inflammati	0.90470516
80	MP0003252_abnormal_bile_duct	0.88596535
81	MP0005085_abnormal_gallbladder_physiolo	0.85983618
82	MP0002722_abnormal_immune_system	0.84044895
83	MP0001984_abnormal_olfaction	0.82888242
84	MP0001853_heart_inflammation	0.82109093
85	MP0005379_endocrine/exocrine_gland_phen	0.81404116
86	MP0002429_abnormal_blood_cell	0.81268305
87	MP0003279_aneurysm	0.81098550
88	MP0006035_abnormal_mitochondrial_morpho	0.80119465
89	MP0005670_abnormal_white_adipose	0.78856713
90	MP0008877_abnormal_DNA_methylation	0.78410328
91	MP0002095_abnormal_skin_pigmentation	0.77639217
92	MP0002282_abnormal_trachea_morphology	0.77014839
93	MP0000465_gastrointestinal_hemorrhage	0.76752595
94	MP0000703_abnormal_thymus_morphology	0.74761905
95	MP0010386_abnormal_urinary_bladder	0.74114347
96	MP0008775_abnormal_heart_ventricle	0.69424451
97	MP0003638_abnormal_response/metabolism_	0.69048355
98	MP0002638_abnormal_pupillary_reflex	0.67965814
99	MP0002009_preneoplasia	0.67897544
100	MP0001756_abnormal_urination	0.66662669

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.81849305
2	Mitochondrial inheritance (HP:0001427)	4.71199186
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.38470176
4	Hepatocellular necrosis (HP:0001404)	4.19478640
5	Increased CSF lactate (HP:0002490)	4.17384740
6	Increased hepatocellular lipid droplets (HP:0006565)	4.10968989
7	Abnormality of cells of the erythroid lineage (HP:0012130)	4.04582188
8	Progressive macrocephaly (HP:0004481)	4.03624416
9	Acute encephalopathy (HP:0006846)	4.00851999
10	Hepatic necrosis (HP:0002605)	4.00078396
11	Abnormal number of erythroid precursors (HP:0012131)	3.85023122
12	Lipid accumulation in hepatocytes (HP:0006561)	3.82770262
13	3-Methylglutaconic aciduria (HP:0003535)	3.78224367
14	IgG deficiency (HP:0004315)	3.53645253
15	Renal Fanconi syndrome (HP:0001994)	3.47658505
16	Macrocytic anemia (HP:0001972)	3.47652688
17	Increased intramyocellular lipid droplets (HP:0012240)	3.29365153
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.24501202
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.24501202
20	Congenital, generalized hypertrichosis (HP:0004540)	3.23278939
21	Reticulocytopenia (HP:0001896)	3.16731469
22	Cerebral edema (HP:0002181)	3.04506347
23	Congenital stationary night blindness (HP:0007642)	3.02938954
24	Severe combined immunodeficiency (HP:0004430)	2.98899875
25	Exertional dyspnea (HP:0002875)	2.98677587
26	Increased serum lactate (HP:0002151)	2.92339971
27	Lactic acidosis (HP:0003128)	2.88489455
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.86793817
29	Renal cortical cysts (HP:0000803)	2.85043336
30	Increased muscle lipid content (HP:0009058)	2.79677086
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.72636638
32	Aplastic anemia (HP:0001915)	2.71147159
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.68758786
34	Abnormality of alanine metabolism (HP:0010916)	2.68758786
35	Hyperalaninemia (HP:0003348)	2.68758786
36	Optic disc pallor (HP:0000543)	2.67948384
37	Pallor (HP:0000980)	2.62257470
38	Pancreatic cysts (HP:0001737)	2.61737851
39	Elevated erythrocyte sedimentation rate (HP:0003565)	2.61689399
40	Methylmalonic acidemia (HP:0002912)	2.55476352
41	Respiratory failure (HP:0002878)	2.54715882
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.43574062
43	Abnormality of the renal cortex (HP:0011035)	2.42694519
44	Generalized aminoaciduria (HP:0002909)	2.42468206
45	Abnormality of midbrain morphology (HP:0002418)	2.38985057
46	Molar tooth sign on MRI (HP:0002419)	2.38985057
47	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.36504878
48	Stomatitis (HP:0010280)	2.34948541
49	Methylmalonic aciduria (HP:0012120)	2.33128118
50	Respiratory difficulties (HP:0002880)	2.29041687
51	Abnormality of renal resorption (HP:0011038)	2.26268744
52	Thyroiditis (HP:0100646)	2.25737717
53	Type I transferrin isoform profile (HP:0003642)	2.25588282
54	Combined immunodeficiency (HP:0005387)	2.24063620
55	Lethargy (HP:0001254)	2.23854446
56	Abnormality of urine glucose concentration (HP:0011016)	2.23605947
57	Glycosuria (HP:0003076)	2.23605947
58	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18527562
59	Exercise intolerance (HP:0003546)	2.12051494
60	Constricted visual fields (HP:0001133)	2.07308587
61	Abolished electroretinogram (ERG) (HP:0000550)	2.06286760
62	Chronic sinusitis (HP:0011109)	2.05273392
63	Hypoproteinemia (HP:0003075)	2.04690295
64	Spontaneous abortion (HP:0005268)	2.04333580
65	Carpal bone hypoplasia (HP:0001498)	2.02317683
66	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.01978255
67	B lymphocytopenia (HP:0010976)	2.01284978
68	Leukodystrophy (HP:0002415)	2.00215341
69	Pancytopenia (HP:0001876)	1.98181653
70	Abnormal hemoglobin (HP:0011902)	1.97998013
71	Parakeratosis (HP:0001036)	1.97280785
72	T lymphocytopenia (HP:0005403)	1.96540665
73	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.94670142
74	Absent thumb (HP:0009777)	1.94505273
75	Abnormality of B cell number (HP:0010975)	1.94284276
76	Type II lissencephaly (HP:0007260)	1.94270114
77	Abnormal protein glycosylation (HP:0012346)	1.93728617
78	Abnormal glycosylation (HP:0012345)	1.93728617
79	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.93728617
80	Abnormal protein N-linked glycosylation (HP:0012347)	1.93728617
81	Reduced antithrombin III activity (HP:0001976)	1.93702940
82	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.93216084
83	Dicarboxylic aciduria (HP:0003215)	1.93216084
84	Abnormality of the prostate (HP:0008775)	1.93115446
85	CNS demyelination (HP:0007305)	1.91385112
86	Abnormality of eosinophils (HP:0001879)	1.89816154
87	Recurrent bronchitis (HP:0002837)	1.88570825
88	Hyperphosphaturia (HP:0003109)	1.85280572
89	Nephronophthisis (HP:0000090)	1.85248916
90	Asplenia (HP:0001746)	1.83015724
91	Attenuation of retinal blood vessels (HP:0007843)	1.82610720
92	Cleft eyelid (HP:0000625)	1.82498967
93	Abnormality of T cell number (HP:0011839)	1.80108612
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.80098057
95	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.79039096
96	Aplasia/hypoplasia of the uterus (HP:0008684)	1.77106229
97	Microretrognathia (HP:0000308)	1.77037296
98	Pancreatic fibrosis (HP:0100732)	1.75833119
99	Abnormality of T cells (HP:0002843)	1.75224743
100	Abnormality of serum amino acid levels (HP:0003112)	1.73268666

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.25338282
2	TLK1	3.80532211
3	TAOK3	2.88673931
4	VRK2	2.88460373
5	ZAK	2.75691973
6	MAP4K2	2.74108643
7	NUAK1	2.67567491
8	BCKDK	2.47512655
9	NME2	2.40628237
10	STK16	2.01957402
11	MAP3K12	2.01701304
12	ADRBK2	1.97114231
13	KIT	1.93092768
14	GRK1	1.91662919
15	CDK19	1.85862825
16	MAP4K1	1.82103980
17	MYLK	1.75002049
18	EIF2AK3	1.70081537
19	IKBKB	1.60467877
20	FRK	1.58550613
21	GRK6	1.52219443
22	KDR	1.51280014
23	VRK1	1.46340665
24	NME1	1.35450142
25	MAP3K14	1.34574803
26	BMPR2	1.33532094
27	SCYL2	1.27397075
28	BUB1	1.26763272
29	TESK2	1.21870794
30	ITK	1.20642872
31	CAMKK2	1.19842925
32	MST4	1.19307228
33	PASK	1.18564810
34	CSF1R	1.11745153
35	BMPR1B	1.11727330
36	PINK1	1.09563011
37	TEC	1.09118881
38	WNK4	1.07857034
39	INSRR	1.06119410
40	ADRBK1	0.99306449
41	IKBKE	0.91915893
42	EIF2AK2	0.91469121
43	MAP2K2	0.91350660
44	RPS6KA5	0.90814254
45	LIMK1	0.89250026
46	FLT3	0.87326327
47	GRK7	0.84569961
48	MUSK	0.83980419
49	SYK	0.82646449
50	OXSR1	0.81752264
51	DAPK1	0.79792749
52	ILK	0.79633535
53	TIE1	0.75169894
54	JAK3	0.75164633
55	FES	0.74741499
56	SRPK1	0.73593480
57	PHKG1	0.72426132
58	PHKG2	0.72426132
59	WNK3	0.71594136
60	LYN	0.70209666
61	PRKCQ	0.65341989
62	DYRK2	0.64452964
63	IGF1R	0.63154273
64	CDK3	0.62171822
65	PLK4	0.62073800
66	ABL2	0.60186982
67	CSNK1G3	0.59859183
68	NEK1	0.59715005
69	TGFBR1	0.59217721
70	LCK	0.59200636
71	MATK	0.56340777
72	MAP2K6	0.55898362
73	CSNK1G1	0.55598917
74	DAPK3	0.55427149
75	NLK	0.53976488
76	CSNK1G2	0.52012653
77	DAPK2	0.50461623
78	OBSCN	0.49342397
79	PIM1	0.48559582
80	CSNK2A2	0.48483899
81	PRKCE	0.48110922
82	RPS6KA4	0.47552381
83	BTK	0.45703085
84	JAK1	0.44420241
85	TBK1	0.44333319
86	PIK3CG	0.44222030
87	PDK2	0.43965403
88	CSNK2A1	0.43574851
89	AURKB	0.43295942
90	PIK3CA	0.42358064
91	BRSK2	0.40862590
92	CHUK	0.40550701
93	PBK	0.39434224
94	STK39	0.37651481
95	TAF1	0.35819691
96	PRKCD	0.35812560
97	TYK2	0.35472557
98	ERBB3	0.35312141
99	CDC7	0.35011030
100	PIM2	0.34654422

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.42911263
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.18769869
3	Parkinsons disease_Homo sapiens_hsa05012	3.40170578
4	Proteasome_Homo sapiens_hsa03050	3.12901435
5	Asthma_Homo sapiens_hsa05310	3.10206071
6	Allograft rejection_Homo sapiens_hsa05330	2.59363814
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.43938785
8	Protein export_Homo sapiens_hsa03060	2.43803598
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.43428725
10	RNA polymerase_Homo sapiens_hsa03020	2.42615318
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.33624670
12	Alzheimers disease_Homo sapiens_hsa05010	2.32063030
13	Huntingtons disease_Homo sapiens_hsa05016	2.20598179
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.13572046
15	Type I diabetes mellitus_Homo sapiens_hsa04940	2.03789283
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.83670787
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.73474116
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.66256391
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.65947814
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.63453466
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61795959
22	Homologous recombination_Homo sapiens_hsa03440	1.59195799
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.49003231
24	Antigen processing and presentation_Homo sapiens_hsa04612	1.43240675
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.33537054
26	Mismatch repair_Homo sapiens_hsa03430	1.29959109
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29947058
28	RNA degradation_Homo sapiens_hsa03018	1.28032748
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.25401733
30	DNA replication_Homo sapiens_hsa03030	1.15263156
31	One carbon pool by folate_Homo sapiens_hsa00670	1.11196512
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.00007622
33	Spliceosome_Homo sapiens_hsa03040	0.99214366
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97329168
35	Purine metabolism_Homo sapiens_hsa00230	0.95241433
36	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88446270
37	Base excision repair_Homo sapiens_hsa03410	0.87722554
38	Phototransduction_Homo sapiens_hsa04744	0.87545392
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86339983
40	Peroxisome_Homo sapiens_hsa04146	0.86231972
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.85843558
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.85014535
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84088725
44	Caffeine metabolism_Homo sapiens_hsa00232	0.78989811
45	Propanoate metabolism_Homo sapiens_hsa00640	0.78558484
46	Basal transcription factors_Homo sapiens_hsa03022	0.76523399
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76475078
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.75731265
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74398491
50	Viral myocarditis_Homo sapiens_hsa05416	0.74272253
51	Regulation of autophagy_Homo sapiens_hsa04140	0.74174562
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72417101
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71089448
54	RNA transport_Homo sapiens_hsa03013	0.69692900
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.69148770
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67754577
57	Fatty acid elongation_Homo sapiens_hsa00062	0.67002831
58	Mineral absorption_Homo sapiens_hsa04978	0.66373357
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.65737912
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65659112
61	Sulfur relay system_Homo sapiens_hsa04122	0.64064501
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63341651
63	Metabolic pathways_Homo sapiens_hsa01100	0.61936534
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.61909207
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61679628
66	Sulfur metabolism_Homo sapiens_hsa00920	0.61026044
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60364291
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59751714
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59620987
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.58780290
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58290063
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58161045
73	Retinol metabolism_Homo sapiens_hsa00830	0.58033767
74	Leishmaniasis_Homo sapiens_hsa05140	0.56489418
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55679288
76	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.53677213
77	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.52516474
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48158613
79	Non-homologous end-joining_Homo sapiens_hsa03450	0.46739654
80	Glutathione metabolism_Homo sapiens_hsa00480	0.44188587
81	Folate biosynthesis_Homo sapiens_hsa00790	0.43143795
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42961484
83	Olfactory transduction_Homo sapiens_hsa04740	0.40688636
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40213680
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.38896878
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36559485
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.35583728
88	Herpes simplex infection_Homo sapiens_hsa05168	0.34757981
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.31808662
90	Butanoate metabolism_Homo sapiens_hsa00650	0.31579250
91	Malaria_Homo sapiens_hsa05144	0.31117013
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31026913
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.30775188
94	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.30180528
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.29253202
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.29025081
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27518566
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27017468
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.26398798
100	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.21389018

RPS4XP22

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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