RPS4XP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.47624527
2NADH metabolic process (GO:0006734)8.92057576
3response to muscle activity (GO:0014850)7.59966538
4negative regulation of Ras GTPase activity (GO:0034261)6.96435302
5regulation of sister chromatid cohesion (GO:0007063)6.41354543
6negative regulation of muscle hypertrophy (GO:0014741)6.35689839
7response to gravity (GO:0009629)6.05592976
8regulation of G0 to G1 transition (GO:0070316)5.55475588
92-oxoglutarate metabolic process (GO:0006103)5.29167917
10negative regulation of telomerase activity (GO:0051974)4.91016402
11DNA deamination (GO:0045006)4.86520704
12skeletal muscle adaptation (GO:0043501)4.73738295
13ribosomal small subunit assembly (GO:0000028)4.71917642
14negative regulation of telomere maintenance (GO:0032205)4.71301636
15DNA damage induced protein phosphorylation (GO:0006975)4.71020000
16striated muscle atrophy (GO:0014891)4.70606667
17regulation of energy homeostasis (GO:2000505)4.64417725
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.63298219
19mitochondrion distribution (GO:0048311)4.61812665
20muscle atrophy (GO:0014889)4.57188721
21phosphorylated carbohydrate dephosphorylation (GO:0046838)4.56204631
22inositol phosphate dephosphorylation (GO:0046855)4.56204631
23positive regulation of RNA splicing (GO:0033120)4.51564808
24protein import into peroxisome matrix (GO:0016558)4.51341431
25tricarboxylic acid metabolic process (GO:0072350)4.47902646
26DNA synthesis involved in DNA repair (GO:0000731)4.47432542
27primary alcohol catabolic process (GO:0034310)4.42317616
28behavioral response to nicotine (GO:0035095)4.35872876
29response to activity (GO:0014823)4.34049943
30protein polyglutamylation (GO:0018095)4.28255307
31actin-myosin filament sliding (GO:0033275)4.23114984
32muscle filament sliding (GO:0030049)4.23114984
33cellular response to dexamethasone stimulus (GO:0071549)4.17496091
34regulation of telomere maintenance via telomerase (GO:0032210)4.12151397
35GMP metabolic process (GO:0046037)3.97081962
36inositol phosphate catabolic process (GO:0071545)3.94879999
37regulation of regulatory T cell differentiation (GO:0045589)3.94113537
38ribosomal large subunit biogenesis (GO:0042273)3.91876247
39response to dexamethasone (GO:0071548)3.86557279
40phosphatidylcholine biosynthetic process (GO:0006656)3.81512580
41regulation of skeletal muscle contraction (GO:0014819)3.73811947
42regulation of T-helper 1 cell differentiation (GO:0045625)3.73226989
43regulation of interleukin-12 biosynthetic process (GO:0045075)3.71552064
44detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.69914191
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.66031734
46histone H4 deacetylation (GO:0070933)3.65134369
47pyrimidine nucleoside salvage (GO:0043097)3.62615230
48pyrimidine-containing compound salvage (GO:0008655)3.62615230
49negative regulation of T-helper cell differentiation (GO:0045623)3.61396404
50negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.61396404
51telomere maintenance via telomerase (GO:0007004)3.59658089
52ribonucleoprotein complex biogenesis (GO:0022613)3.51186486
53skeletal muscle tissue regeneration (GO:0043403)3.44889530
54negative regulation of DNA biosynthetic process (GO:2000279)3.41709336
55positive regulation of Notch signaling pathway (GO:0045747)3.41559843
56positive regulation of chemokine secretion (GO:0090197)3.36452436
57cell proliferation in forebrain (GO:0021846)3.32769989
58kidney morphogenesis (GO:0060993)3.32633455
59detection of mechanical stimulus (GO:0050982)3.32276229
60detection of mechanical stimulus involved in sensory perception (GO:0050974)3.30123767
61regulation of telomerase activity (GO:0051972)3.28310382
62heart trabecula morphogenesis (GO:0061384)3.22789961
63prostanoid biosynthetic process (GO:0046457)3.21417479
64prostaglandin biosynthetic process (GO:0001516)3.21417479
65actin-mediated cell contraction (GO:0070252)3.20246203
66activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.19331361
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19283253
68positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.18976198
69histone H3 deacetylation (GO:0070932)3.18919730
70lymphangiogenesis (GO:0001946)3.16548908
71negative regulation of GTP catabolic process (GO:0033125)3.12503564
72negative regulation of GTPase activity (GO:0034260)3.12503564
73negative regulation of alpha-beta T cell differentiation (GO:0046639)3.11923178
74RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.04515675
75regulation of helicase activity (GO:0051095)3.01177143
76cardiolipin metabolic process (GO:0032048)3.01061618
77artery development (GO:0060840)3.00993223
78regulation of cholesterol biosynthetic process (GO:0045540)3.00559383
79sister chromatid cohesion (GO:0007062)3.00082968
80retina development in camera-type eye (GO:0060041)2.97402834
81lymph node development (GO:0048535)2.92687624
82negative regulation of skeletal muscle tissue development (GO:0048642)2.88901802
83activated T cell proliferation (GO:0050798)2.85729658
84positive regulation of DNA biosynthetic process (GO:2000573)2.84655679
85regulation of chemokine secretion (GO:0090196)2.84477897
86regulation of telomere maintenance (GO:0032204)2.83112041
87phosphatidylglycerol biosynthetic process (GO:0006655)2.82702325
88regulation of gamma-delta T cell differentiation (GO:0045586)2.82016584
89protein targeting to peroxisome (GO:0006625)2.81836215
90establishment of protein localization to peroxisome (GO:0072663)2.81836215
91protein localization to peroxisome (GO:0072662)2.81836215
92response to vitamin D (GO:0033280)2.78268543
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76253713
94viral transcription (GO:0019083)2.75878805
95positive regulation of meiosis (GO:0045836)2.75365182
96negative regulation of phagocytosis (GO:0050765)2.74209252
97translational elongation (GO:0006414)2.71976488
98reflex (GO:0060004)2.71300882
99ethanol metabolic process (GO:0006067)2.68055123
100ncRNA 3-end processing (GO:0043628)12.5727757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat8.29913345
2EZH2_22144423_ChIP-Seq_EOC_Human4.63296547
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.56685943
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.53277455
5VDR_22108803_ChIP-Seq_LS180_Human4.03076379
6AR_21572438_ChIP-Seq_LNCaP_Human3.43099061
7TAF15_26573619_Chip-Seq_HEK293_Human2.94513145
8HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.84783528
9GBX2_23144817_ChIP-Seq_PC3_Human2.57451005
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55303041
11FUS_26573619_Chip-Seq_HEK293_Human2.46853969
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.45909785
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33935945
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.09227385
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90109262
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.78386032
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.75422061
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71856170
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71255979
20ZNF274_21170338_ChIP-Seq_K562_Hela1.70211492
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.69767175
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67123027
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66783586
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65608377
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63886088
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62905999
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.61024817
28EGR1_19032775_ChIP-ChIP_M12_Human1.51007157
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50510461
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50402312
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49969612
32EWS_26573619_Chip-Seq_HEK293_Human1.48608766
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.46753458
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39694668
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39364008
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39060845
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38244144
38REST_21632747_ChIP-Seq_MESCs_Mouse1.37199598
39ER_23166858_ChIP-Seq_MCF-7_Human1.36340952
40TP53_22573176_ChIP-Seq_HFKS_Human1.35943428
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.35431398
42NCOR_22424771_ChIP-Seq_293T_Human1.34513847
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33592107
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33592107
45BCAT_22108803_ChIP-Seq_LS180_Human1.30619433
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29245804
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28321191
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24125068
49P300_19829295_ChIP-Seq_ESCs_Human1.23561902
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23097459
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22948427
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.22617478
53RNF2_27304074_Chip-Seq_NSC_Mouse1.21791053
54SMAD4_21799915_ChIP-Seq_A2780_Human1.20934412
55CBP_20019798_ChIP-Seq_JUKART_Human1.19352830
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19352830
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.18061238
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17463948
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15143466
60ERA_21632823_ChIP-Seq_H3396_Human1.14570806
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.13611953
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13279617
63IGF1R_20145208_ChIP-Seq_DFB_Human1.12174021
64BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08912099
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08575665
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07266557
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06549558
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06549558
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06321420
70NANOG_20526341_ChIP-Seq_ESCs_Human1.06173134
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05317963
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02501476
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01726184
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.01165600
75SMRT_27268052_Chip-Seq_Bcells_Human0.99871528
76KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99143904
77TAL1_26923725_Chip-Seq_HPCs_Mouse0.96510090
78STAT3_23295773_ChIP-Seq_U87_Human0.95770786
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95328820
80SMAD4_21741376_ChIP-Seq_EPCs_Human0.94572834
81HTT_18923047_ChIP-ChIP_STHdh_Human0.93755820
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93697854
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91593168
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91353699
85TP53_16413492_ChIP-PET_HCT116_Human0.90368069
86EST1_17652178_ChIP-ChIP_JURKAT_Human0.88193207
87FLI1_27457419_Chip-Seq_LIVER_Mouse0.87861380
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.86748001
89POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84805984
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84196709
91AR_20517297_ChIP-Seq_VCAP_Human0.82806489
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82739286
93TP53_20018659_ChIP-ChIP_R1E_Mouse0.82545609
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81777571
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81505026
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81305275
97NANOG_19829295_ChIP-Seq_ESCs_Human0.79051991
98SOX2_19829295_ChIP-Seq_ESCs_Human0.79051991
99MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.78528489
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78330148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis7.60274510
2MP0003879_abnormal_hair_cell4.23092409
3MP0006082_CNS_inflammation4.17928287
4MP0004145_abnormal_muscle_electrophysio3.90101424
5MP0001727_abnormal_embryo_implantation3.82772321
6MP0001873_stomach_inflammation3.79211558
7MP0003121_genomic_imprinting3.62884610
8MP0009780_abnormal_chondrocyte_physiolo3.35429234
9MP0006292_abnormal_olfactory_placode2.91302851
10MP0002102_abnormal_ear_morphology2.37492062
11MP0004270_analgesia2.33074554
12MP0002163_abnormal_gland_morphology2.22454541
13MP0004036_abnormal_muscle_relaxation2.08414662
14MP0003880_abnormal_central_pattern2.04480371
15MP0000566_synostosis2.02172062
16MP0002089_abnormal_postnatal_growth/wei1.89572297
17MP0003195_calcinosis1.82363349
18MP0001968_abnormal_touch/_nociception1.76821161
19MP0005646_abnormal_pituitary_gland1.76140185
20MP0002108_abnormal_muscle_morphology1.73216065
21MP0002933_joint_inflammation1.69440090
22MP0008875_abnormal_xenobiotic_pharmacok1.68754924
23MP0006276_abnormal_autonomic_nervous1.68366364
24MP0002638_abnormal_pupillary_reflex1.66858629
25MP0003646_muscle_fatigue1.65898115
26MP0000747_muscle_weakness1.63554464
27MP0004133_heterotaxia1.58651913
28MP0005075_abnormal_melanosome_morpholog1.41912273
29MP0000427_abnormal_hair_cycle1.36493999
30MP0000749_muscle_degeneration1.32187876
31MP0004084_abnormal_cardiac_muscle1.30381764
32MP0001663_abnormal_digestive_system1.28541636
33MP0002735_abnormal_chemical_nociception1.27708271
34MP0002733_abnormal_thermal_nociception1.25224964
35MP0000778_abnormal_nervous_system1.24665786
36MP0005379_endocrine/exocrine_gland_phen1.23419899
37MP0005551_abnormal_eye_electrophysiolog1.18515652
38MP0002106_abnormal_muscle_physiology1.18061385
39MP0002876_abnormal_thyroid_physiology1.17168787
40MP0005369_muscle_phenotype1.16661656
41MP0005620_abnormal_muscle_contractility1.11816355
42MP0002734_abnormal_mechanical_nocicepti1.10418191
43MP0005645_abnormal_hypothalamus_physiol1.09288932
44MP0001970_abnormal_pain_threshold1.09067295
45MP0008995_early_reproductive_senescence1.08437344
46MP0009745_abnormal_behavioral_response1.08165250
47MP0002736_abnormal_nociception_after1.07977615
48MP0001851_eye_inflammation1.07765216
49MP0003763_abnormal_thymus_physiology1.07006194
50MP0008877_abnormal_DNA_methylation1.06213135
51MP0003693_abnormal_embryo_hatching1.05241040
52MP0002095_abnormal_skin_pigmentation1.04759165
53MP0002837_dystrophic_cardiac_calcinosis1.04284850
54MP0009765_abnormal_xenobiotic_induced1.04220667
55MP0003938_abnormal_ear_development1.02471917
56MP0002272_abnormal_nervous_system0.99147833
57MP0005174_abnormal_tail_pigmentation0.98951052
58MP0010386_abnormal_urinary_bladder0.98529665
59MP0000372_irregular_coat_pigmentation0.95229614
60MP0003787_abnormal_imprinting0.94757590
61MP0000631_abnormal_neuroendocrine_gland0.89547012
62MP0000015_abnormal_ear_pigmentation0.88281884
63MP0004947_skin_inflammation0.86942446
64MP0001905_abnormal_dopamine_level0.84655411
65MP0003635_abnormal_synaptic_transmissio0.83747228
66MP0004742_abnormal_vestibular_system0.83046670
67MP0009250_abnormal_appendicular_skeleto0.82441911
68MP0001919_abnormal_reproductive_system0.81097566
69MP0005381_digestive/alimentary_phenotyp0.80938751
70MP0002127_abnormal_cardiovascular_syste0.80855279
71MP0005195_abnormal_posterior_eye0.80627853
72MP0002277_abnormal_respiratory_mucosa0.76435339
73MP0005389_reproductive_system_phenotype0.75384528
74MP0004484_altered_response_of0.74065262
75MP0002269_muscular_atrophy0.73636001
76MP0002116_abnormal_craniofacial_bone0.72947686
77MP0008775_abnormal_heart_ventricle0.72651519
78MP0004043_abnormal_pH_regulation0.71566529
79MP0002572_abnormal_emotion/affect_behav0.71337770
80MP0001800_abnormal_humoral_immune0.66985905
81MP0001915_intracranial_hemorrhage0.66824019
82MP0000759_abnormal_skeletal_muscle0.66781435
83MP0001177_atelectasis0.64920331
84MP0009785_altered_susceptibility_to0.64401717
85MP0009333_abnormal_splenocyte_physiolog0.63091445
86MP0005595_abnormal_vascular_smooth0.62265953
87MP0005671_abnormal_response_to0.61855454
88MP0001835_abnormal_antigen_presentation0.61029156
89MP0000026_abnormal_inner_ear0.60979156
90MP0001963_abnormal_hearing_physiology0.60816775
91MP0003786_premature_aging0.59301993
92MP0003283_abnormal_digestive_organ0.58869579
93MP0002160_abnormal_reproductive_system0.58255950
94MP0001986_abnormal_taste_sensitivity0.57081875
95MP0002184_abnormal_innervation0.55590543
96MP0005197_abnormal_uvea_morphology0.55533434
97MP0004142_abnormal_muscle_tone0.55392723
98MP0002210_abnormal_sex_determination0.55237130
99MP0002063_abnormal_learning/memory/cond0.54704010
100MP0002752_abnormal_somatic_nervous0.54384707

Predicted human phenotypes

RankGene SetZ-score
1Round ear (HP:0100830)9.96212989
2Abnormality of macular pigmentation (HP:0008002)8.49967001
3Volvulus (HP:0002580)8.27410938
4Striae distensae (HP:0001065)7.86853003
5Metaphyseal cupping (HP:0003021)7.43411661
6Constricted visual fields (HP:0001133)6.92458011
7Large earlobe (HP:0009748)6.50671465
8Cupped ribs (HP:0000887)6.29924548
9Cone-rod dystrophy (HP:0000548)6.11593809
10Toxemia of pregnancy (HP:0100603)5.97919867
11Attenuation of retinal blood vessels (HP:0007843)5.25835386
12Decreased electroretinogram (ERG) amplitude (HP:0000654)5.12960427
13Oligodontia (HP:0000677)4.50718458
14Palpebral edema (HP:0100540)4.11763302
15Decreased muscle mass (HP:0003199)3.78974232
16Small hand (HP:0200055)3.67067540
17Ovoid vertebral bodies (HP:0003300)3.56988846
18Lack of skin elasticity (HP:0100679)3.52153870
19Abnormality of the labia minora (HP:0012880)3.42022628
20Severe visual impairment (HP:0001141)3.28240418
21Tibial bowing (HP:0002982)3.23134283
22Broad nasal tip (HP:0000455)3.08826476
23Concave nail (HP:0001598)3.06841374
24Proximal placement of thumb (HP:0009623)3.04651894
25Truncal obesity (HP:0001956)2.95054798
26Femoral bowing (HP:0002980)2.77722497
27Freckling (HP:0001480)2.70728537
28Prominent supraorbital ridges (HP:0000336)2.68817482
29Optic disc pallor (HP:0000543)2.68514976
30Hypoplastic ischia (HP:0003175)2.65988367
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.63076480
32Deviation of the thumb (HP:0009603)2.60500492
33Hypoplastic ilia (HP:0000946)2.54913733
34Widely spaced teeth (HP:0000687)2.53223118
35Absent phalangeal crease (HP:0006109)2.53178289
36Limited elbow extension (HP:0001377)2.51073019
37Distal arthrogryposis (HP:0005684)2.49473129
38Coxa vara (HP:0002812)2.48560028
39Blepharitis (HP:0000498)2.40642915
40Melanoma (HP:0002861)2.37293759
41Progressive visual loss (HP:0000529)2.30355173
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.22920352
43Abnormality of the ischium (HP:0003174)2.21919342
44Abnormal finger flexion creases (HP:0006143)2.19746076
45Brushfield spots (HP:0001088)2.19609722
46Hematochezia (HP:0002573)2.15853751
47Aplasia/Hypoplasia of the nipples (HP:0006709)2.11551494
48Postnatal growth retardation (HP:0008897)2.09737720
49Nemaline bodies (HP:0003798)2.08583994
50Low posterior hairline (HP:0002162)2.06465265
51Recurrent otitis media (HP:0000403)2.05488505
52Mask-like facies (HP:0000298)2.05205946
53Delayed puberty (HP:0000823)2.04622860
54Calcaneovalgus deformity (HP:0001848)2.04546419
55Congenital sensorineural hearing impairment (HP:0008527)2.03998501
56Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01991562
57Albinism (HP:0001022)1.98811465
58Abnormality of lateral ventricle (HP:0030047)1.96227727
59Rhizomelia (HP:0008905)1.94797230
60Long eyelashes (HP:0000527)1.94250544
61Thickened nuchal skin fold (HP:0000474)1.93090967
62Exercise-induced myalgia (HP:0003738)1.90079185
63Increased nuchal translucency (HP:0010880)1.89205074
64Ulnar deviation of the wrist (HP:0003049)1.88356860
65Hip contracture (HP:0003273)1.88123463
66Preauricular skin tag (HP:0000384)1.86216846
67Periorbital edema (HP:0100539)1.84800795
68Deformed tarsal bones (HP:0008119)1.82178820
69Muscle fiber inclusion bodies (HP:0100299)1.79072419
70Lymphedema (HP:0001004)1.77235834
71Prenatal maternal abnormality (HP:0002686)1.76914863
72Facial edema (HP:0000282)1.73733262
73Esophageal atresia (HP:0002032)1.73196126
74Muscle fiber splitting (HP:0003555)1.72319429
75Single transverse palmar crease (HP:0000954)1.70119475
76Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68762302
77Asplenia (HP:0001746)1.66132805
78Skin tags (HP:0010609)1.65080142
79Increased connective tissue (HP:0009025)1.64231469
80Abnormality of the aortic arch (HP:0012303)1.62668115
81Abnormality of the antihelix (HP:0009738)1.60480809
82Cutis marmorata (HP:0000965)1.59464760
83Childhood onset (HP:0011463)1.59352246
84Hyperthyroidism (HP:0000836)1.59214996
85Increased serum pyruvate (HP:0003542)1.58773708
86Neoplasm of the oral cavity (HP:0100649)1.58706555
87Pointed chin (HP:0000307)1.57503707
88Hypomagnesemia (HP:0002917)1.56363595
89Tapered finger (HP:0001182)1.54548814
90Low anterior hairline (HP:0000294)1.54044030
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.53595146
92Congenital stationary night blindness (HP:0007642)1.53377752
93Aplasia cutis congenita (HP:0001057)1.52145859
94Photophobia (HP:0000613)1.51939996
95Hyperglycinemia (HP:0002154)1.49997153
96Retinitis pigmentosa (HP:0000510)1.48676828
97Retinopathy (HP:0000488)1.47125510
98Abnormality of the nasal septum (HP:0000419)1.46511502
99Type 1 muscle fiber predominance (HP:0003803)1.45345106
100Congenital, generalized hypertrichosis (HP:0004540)1.44729171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT7.14560750
2TAOK25.93971376
3MAP4K25.50087571
4FES4.14010451
5TLK13.47822249
6SIK23.31453446
7TEC3.27065794
8MAP2K63.04912691
9TYRO32.55639340
10CASK1.89291403
11WNK41.88170112
12MAP3K51.77776912
13MAP4K11.59058368
14OBSCN1.58198843
15TIE11.56597514
16SYK1.49411996
17PHKG11.41368417
18PHKG21.41368417
19BCKDK1.40846684
20CDK191.39595894
21IKBKB1.36783915
22CSK1.29940758
23RET1.15310362
24WNK31.10928949
25ADRBK21.05424305
26STK391.02952260
27CDK30.98003052
28MAPKAPK50.97494589
29NUAK10.89972079
30FRK0.88007129
31OXSR10.87545583
32MAPK130.86852071
33NEK20.82941204
34GRK10.80200236
35PRKCQ0.78503030
36TESK20.76261128
37PIK3CA0.75131268
38CSF1R0.75049468
39IKBKE0.71760414
40TAF10.69721124
41NME10.69377913
42EPHB20.68048200
43TXK0.65917693
44MARK10.58372171
45INSR0.55321248
46BTK0.54436189
47EGFR0.53942625
48LIMK10.50546394
49JAK30.49985355
50TNK20.48731790
51RPS6KB20.48454777
52ADRBK10.47507546
53PRKACA0.47386702
54INSRR0.47343756
55PDK20.47235731
56DYRK20.44747974
57MKNK10.44070000
58TAOK30.42480290
59CSNK1D0.42111280
60ZAK0.40877406
61AURKA0.40350007
62SRC0.39768378
63LCK0.39658955
64FGR0.37786973
65MAP3K80.37212633
66CHEK20.36726065
67LYN0.36037389
68MUSK0.34820374
69TBK10.34174316
70MAP3K110.34031381
71PIK3CG0.33624778
72MINK10.33066993
73ATM0.31535297
74PRKCA0.31429772
75PRKACG0.31009015
76RIPK40.30692984
77VRK10.30150548
78PINK10.29414121
79MAPK100.29357110
80ABL10.28987197
81ATR0.28333495
82PRKCG0.27311356
83MAP2K70.26962312
84ABL20.25545605
85VRK20.25234334
86MAP3K40.24874472
87PRKCE0.24629748
88BMPR1B0.23601623
89PRKCB0.23384741
90PRKACB0.23327515
91GRK50.23197305
92EPHA40.20519279
93PRKDC0.19711565
94STK38L0.19561493
95NTRK20.17993817
96GRK70.15874371
97RPS6KA40.15864947
98TESK10.15647888
99FER0.14396492
100MST40.14331373

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012105.15132995
2Phototransduction_Homo sapiens_hsa047443.54621416
3Ribosome_Homo sapiens_hsa030102.84258413
4Oxidative phosphorylation_Homo sapiens_hsa001902.72151177
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51652669
6Asthma_Homo sapiens_hsa053102.29824176
7Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.24124797
8Nicotine addiction_Homo sapiens_hsa050332.23514676
9Allograft rejection_Homo sapiens_hsa053302.11414763
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.09249710
11Autoimmune thyroid disease_Homo sapiens_hsa053202.07072183
12Graft-versus-host disease_Homo sapiens_hsa053321.89664296
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89198466
14Parkinsons disease_Homo sapiens_hsa050121.87599004
15Tryptophan metabolism_Homo sapiens_hsa003801.82687164
16Histidine metabolism_Homo sapiens_hsa003401.80572701
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.80082796
18Olfactory transduction_Homo sapiens_hsa047401.58142782
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.56796113
20Arachidonic acid metabolism_Homo sapiens_hsa005901.56326943
21Alzheimers disease_Homo sapiens_hsa050101.54978805
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52350840
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43273697
24Type I diabetes mellitus_Homo sapiens_hsa049401.42490130
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33282727
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29149842
27Linoleic acid metabolism_Homo sapiens_hsa005911.28989472
28Hematopoietic cell lineage_Homo sapiens_hsa046401.27454504
29Long-term potentiation_Homo sapiens_hsa047201.25411510
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21447874
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.20489055
32Vitamin B6 metabolism_Homo sapiens_hsa007501.12625056
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12320359
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07148407
35Alcoholism_Homo sapiens_hsa050341.06399960
36Calcium signaling pathway_Homo sapiens_hsa040201.06351143
37Rheumatoid arthritis_Homo sapiens_hsa053231.06062669
38Tight junction_Homo sapiens_hsa045301.01659352
39Viral myocarditis_Homo sapiens_hsa054161.00384309
40Serotonergic synapse_Homo sapiens_hsa047260.99181482
41Peroxisome_Homo sapiens_hsa041460.97686080
42Systemic lupus erythematosus_Homo sapiens_hsa053220.94567832
43Long-term depression_Homo sapiens_hsa047300.94238167
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93795822
45Caffeine metabolism_Homo sapiens_hsa002320.93661227
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.91880223
47Taste transduction_Homo sapiens_hsa047420.90491244
48Cardiac muscle contraction_Homo sapiens_hsa042600.88775227
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86738079
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85778299
51Staphylococcus aureus infection_Homo sapiens_hsa051500.79584380
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77351133
53beta-Alanine metabolism_Homo sapiens_hsa004100.75750166
54Circadian entrainment_Homo sapiens_hsa047130.71972540
55Huntingtons disease_Homo sapiens_hsa050160.71805408
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.71612746
57Morphine addiction_Homo sapiens_hsa050320.71524834
58Salivary secretion_Homo sapiens_hsa049700.71185913
59Primary immunodeficiency_Homo sapiens_hsa053400.71083224
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.70346991
61Oxytocin signaling pathway_Homo sapiens_hsa049210.70158115
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69654330
63T cell receptor signaling pathway_Homo sapiens_hsa046600.68063851
64Insulin secretion_Homo sapiens_hsa049110.67803415
65Chemical carcinogenesis_Homo sapiens_hsa052040.66921320
66Retinol metabolism_Homo sapiens_hsa008300.66515345
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64073584
68Nitrogen metabolism_Homo sapiens_hsa009100.60816363
69Proteasome_Homo sapiens_hsa030500.60615279
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60604138
71Pyruvate metabolism_Homo sapiens_hsa006200.60371252
72Amphetamine addiction_Homo sapiens_hsa050310.60244434
73Sulfur metabolism_Homo sapiens_hsa009200.58772291
74Regulation of autophagy_Homo sapiens_hsa041400.57640871
75FoxO signaling pathway_Homo sapiens_hsa040680.56075466
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55186269
77GABAergic synapse_Homo sapiens_hsa047270.53722544
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52857864
79Cholinergic synapse_Homo sapiens_hsa047250.51473501
80Cocaine addiction_Homo sapiens_hsa050300.48642664
81Dilated cardiomyopathy_Homo sapiens_hsa054140.46462380
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46406408
83Mismatch repair_Homo sapiens_hsa034300.46110746
84Malaria_Homo sapiens_hsa051440.46037669
85Butanoate metabolism_Homo sapiens_hsa006500.45732104
86Glutamatergic synapse_Homo sapiens_hsa047240.41577936
87Biosynthesis of amino acids_Homo sapiens_hsa012300.39961053
88Choline metabolism in cancer_Homo sapiens_hsa052310.39474094
89Renin secretion_Homo sapiens_hsa049240.39399532
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38499121
91Ovarian steroidogenesis_Homo sapiens_hsa049130.38491501
92Glycerolipid metabolism_Homo sapiens_hsa005610.38247245
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38156892
94Dopaminergic synapse_Homo sapiens_hsa047280.35043133
95GnRH signaling pathway_Homo sapiens_hsa049120.35000592
96Fatty acid degradation_Homo sapiens_hsa000710.34973189
97Basal transcription factors_Homo sapiens_hsa030220.34539795
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34066458
99Gastric acid secretion_Homo sapiens_hsa049710.31378200
100RNA degradation_Homo sapiens_hsa030180.28896962

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