ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.15673981
2	translational termination (GO:0006415)	7.68803063
3	ribosomal small subunit assembly (GO:0000028)	7.23398218
4	maturation of SSU-rRNA (GO:0030490)	6.84461345
5	translational elongation (GO:0006414)	6.52555580
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.41992521
7	cotranslational protein targeting to membrane (GO:0006613)	6.34535003
8	protein targeting to ER (GO:0045047)	6.33785903
9	ribosomal small subunit biogenesis (GO:0042274)	5.99879874
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.98556341
11	protein neddylation (GO:0045116)	5.97281126
12	protein localization to endoplasmic reticulum (GO:0070972)	5.89881368
13	cellular protein complex disassembly (GO:0043624)	5.87968802
14	viral life cycle (GO:0019058)	5.87331266
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.71465063
16	protein polyglutamylation (GO:0018095)	5.43626695
17	ribosomal large subunit biogenesis (GO:0042273)	5.13561539
18	translational initiation (GO:0006413)	5.11371469
19	protein complex disassembly (GO:0043241)	5.02990926
20	macromolecular complex disassembly (GO:0032984)	4.85888355
21	piRNA metabolic process (GO:0034587)	4.47666939
22	behavioral response to nicotine (GO:0035095)	4.38039251
23	chaperone-mediated protein transport (GO:0072321)	4.36895066
24	protein targeting to membrane (GO:0006612)	4.35405276
25	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.29258249
26	ATP synthesis coupled proton transport (GO:0015986)	4.29258249
27	DNA deamination (GO:0045006)	4.14971355
28	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.02778726
29	translation (GO:0006412)	3.99368206
30	sperm motility (GO:0030317)	3.96652268
31	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.89056865
32	mRNA catabolic process (GO:0006402)	3.78806344
33	DNA methylation involved in gamete generation (GO:0043046)	3.78219365
34	epithelial cilium movement (GO:0003351)	3.73733786
35	GTP biosynthetic process (GO:0006183)	3.70738075
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.66072215
37	rRNA modification (GO:0000154)	3.62950102
38	axoneme assembly (GO:0035082)	3.43416808
39	protein complex biogenesis (GO:0070271)	3.38868620
40	ribonucleoprotein complex biogenesis (GO:0022613)	3.36371341
41	RNA catabolic process (GO:0006401)	3.36121719
42	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.36009886
43	centriole replication (GO:0007099)	3.32942459
44	regulation of cilium movement (GO:0003352)	3.27308245
45	hypothalamus development (GO:0021854)	3.24590935
46	electron transport chain (GO:0022900)	3.23625548
47	response to pheromone (GO:0019236)	3.21915755
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.21065903
49	NADH dehydrogenase complex assembly (GO:0010257)	3.21065903
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.21065903
51	respiratory electron transport chain (GO:0022904)	3.20866533
52	UTP biosynthetic process (GO:0006228)	3.20794787
53	cellular component biogenesis (GO:0044085)	3.18877412
54	cell proliferation in forebrain (GO:0021846)	3.17498812
55	motile cilium assembly (GO:0044458)	3.16547943
56	seminiferous tubule development (GO:0072520)	3.08851770
57	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.07477170
58	hydrogen ion transmembrane transport (GO:1902600)	3.06491611
59	parturition (GO:0007567)	3.02022147
60	cilium movement (GO:0003341)	2.95566411
61	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.94998545
62	UTP metabolic process (GO:0046051)	2.92073994
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91799693
64	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.86955271
65	protein targeting (GO:0006605)	2.86776519
66	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.85059441
67	organelle disassembly (GO:1903008)	2.83077183
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.78861831
69	proton transport (GO:0015992)	2.78687795
70	protein-cofactor linkage (GO:0018065)	2.78340360
71	base-excision repair, AP site formation (GO:0006285)	2.75632756
72	synaptic transmission, cholinergic (GO:0007271)	2.75514225
73	response to redox state (GO:0051775)	2.75058826
74	positive regulation of fatty acid transport (GO:2000193)	2.73949994
75	ubiquinone biosynthetic process (GO:0006744)	2.73619660
76	establishment of protein localization to membrane (GO:0090150)	2.72786582
77	protein targeting to Golgi (GO:0000042)	2.72770043
78	hydrogen transport (GO:0006818)	2.72227852
79	regulation of microtubule-based movement (GO:0060632)	2.70236237
80	somite development (GO:0061053)	2.69777890
81	positive regulation of prostaglandin secretion (GO:0032308)	2.68454414
82	establishment of protein localization to Golgi (GO:0072600)	2.66125998
83	establishment of protein localization to organelle (GO:0072594)	2.66106792
84	L-serine metabolic process (GO:0006563)	2.66035837
85	male meiosis I (GO:0007141)	2.66002885
86	positive regulation of icosanoid secretion (GO:0032305)	2.65446605
87	axonemal dynein complex assembly (GO:0070286)	2.63187141
88	DNA modification (GO:0006304)	2.62027223
89	ribonucleoprotein complex disassembly (GO:0032988)	2.61844684
90	spermatid development (GO:0007286)	2.58783833
91	head development (GO:0060322)	2.58326379
92	tRNA processing (GO:0008033)	2.58156457
93	ATP biosynthetic process (GO:0006754)	2.58003031
94	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.57498925
95	rRNA methylation (GO:0031167)	2.55363874
96	nonmotile primary cilium assembly (GO:0035058)	2.54452628
97	centriole assembly (GO:0098534)	2.52757512
98	body morphogenesis (GO:0010171)	2.51764093
99	DNA methylation or demethylation (GO:0044728)	2.50285268
100	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.50279297

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.48699218
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.16162710
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.22543578
4	VDR_22108803_ChIP-Seq_LS180_Human	2.99153029
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.93065249
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.52370370
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.51914044
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35464166
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.27239621
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22061730
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20012612
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.18108956
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.14202085
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.07949829
15	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.99265195
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.94548959
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.91344683
18	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.80245010
19	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.78775361
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78245516
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78089612
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.60410483
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.57006723
24	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.56941932
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47331082
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.46981459
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.46692363
28	ERA_21632823_ChIP-Seq_H3396_Human	1.39119662
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38695306
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38173844
31	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.37175438
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.37051260
33	FUS_26573619_Chip-Seq_HEK293_Human	1.36990846
34	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.35498640
35	CTCF_20526341_ChIP-Seq_ESCs_Human	1.35334172
36	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.32919335
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.32606563
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32062053
39	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.31422175
40	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.30897684
41	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.29506511
42	P53_21459846_ChIP-Seq_SAOS-2_Human	1.27820232
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27559747
44	MYC_19829295_ChIP-Seq_ESCs_Human	1.26186882
45	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.22791594
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20672202
47	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.20037809
48	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.19363586
49	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18935526
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16855529
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.13194715
52	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.12694113
53	FOXP3_21729870_ChIP-Seq_TREG_Human	1.11243911
54	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.10331819
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.09983679
56	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.08841028
57	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07477380
58	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.06443637
59	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.05812001
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05128015
61	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04685144
62	XRN2_22483619_ChIP-Seq_HELA_Human	1.04572843
63	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.03766114
64	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.02377255
65	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01811578
66	RAC3_21632823_ChIP-Seq_H3396_Human	1.01525879
67	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00871532
68	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.00556802
69	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.99795922
70	OCT4_20526341_ChIP-Seq_ESCs_Human	0.99627131
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99456674
72	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.99420596
73	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99278909
74	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99278909
75	ELK1_19687146_ChIP-ChIP_HELA_Human	0.99049746
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99010648
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99010648
78	NCOR_22424771_ChIP-Seq_293T_Human	0.98865621
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98016055
80	BCL6_27268052_Chip-Seq_Bcells_Human	0.97412300
81	ER_23166858_ChIP-Seq_MCF-7_Human	0.96650912
82	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.95202046
83	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94929612
84	CTCF_27219007_Chip-Seq_Bcells_Human	0.94768406
85	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.94480536
86	EWS_26573619_Chip-Seq_HEK293_Human	0.93680783
87	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93507076
88	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92903990
89	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.92599138
90	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92396178
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92176995
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.91754945
93	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.91432926
94	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.90969513
95	P300_27268052_Chip-Seq_Bcells_Human	0.90938216
96	AR_20517297_ChIP-Seq_VCAP_Human	0.89991528
97	E2F1_20622854_ChIP-Seq_HELA_Human	0.89452836
98	GABP_19822575_ChIP-Seq_HepG2_Human	0.88140625
99	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.87804400
100	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.87088512

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.97316676
2	MP0008877_abnormal_DNA_methylation	3.10771731
3	MP0003123_paternal_imprinting	2.44384007
4	MP0004885_abnormal_endolymph	2.43615694
5	MP0003787_abnormal_imprinting	2.39659682
6	MP0006292_abnormal_olfactory_placode	2.38651697
7	MP0003878_abnormal_ear_physiology	2.34958396
8	MP0005377_hearing/vestibular/ear_phenot	2.34958396
9	MP0001986_abnormal_taste_sensitivity	2.27000127
10	MP0002736_abnormal_nociception_after	2.22314742
11	MP0001968_abnormal_touch/_nociception	2.22166356
12	MP0005410_abnormal_fertilization	2.05787696
13	MP0003122_maternal_imprinting	2.02477998
14	MP0004142_abnormal_muscle_tone	1.97934497
15	MP0001984_abnormal_olfaction	1.91792701
16	MP0000631_abnormal_neuroendocrine_gland	1.89941982
17	MP0001440_abnormal_grooming_behavior	1.89869024
18	MP0002876_abnormal_thyroid_physiology	1.84148518
19	MP0003121_genomic_imprinting	1.82178152
20	MP0008789_abnormal_olfactory_epithelium	1.81991792
21	MP0001293_anophthalmia	1.79492347
22	MP0008872_abnormal_physiological_respon	1.77517082
23	MP0003011_delayed_dark_adaptation	1.76521758
24	MP0003646_muscle_fatigue	1.74385835
25	MP0005551_abnormal_eye_electrophysiolog	1.72776329
26	MP0000778_abnormal_nervous_system	1.70020791
27	MP0008875_abnormal_xenobiotic_pharmacok	1.69420164
28	MP0006276_abnormal_autonomic_nervous	1.69345412
29	MP0002653_abnormal_ependyma_morphology	1.68828064
30	MP0006072_abnormal_retinal_apoptosis	1.67685785
31	MP0001485_abnormal_pinna_reflex	1.65022723
32	MP0001529_abnormal_vocalization	1.58809892
33	MP0002557_abnormal_social/conspecific_i	1.52994869
34	MP0003879_abnormal_hair_cell	1.52743119
35	MP0001905_abnormal_dopamine_level	1.52564595
36	MP0002272_abnormal_nervous_system	1.51778311
37	MP0002572_abnormal_emotion/affect_behav	1.50177684
38	MP0002735_abnormal_chemical_nociception	1.47390151
39	MP0002928_abnormal_bile_duct	1.46949833
40	MP0005646_abnormal_pituitary_gland	1.45924827
41	MP0002160_abnormal_reproductive_system	1.43018856
42	MP0009745_abnormal_behavioral_response	1.41989568
43	MP0005360_urolithiasis	1.41293164
44	MP0002063_abnormal_learning/memory/cond	1.38310040
45	MP0001970_abnormal_pain_threshold	1.38028110
46	MP0002733_abnormal_thermal_nociception	1.36473648
47	MP0005670_abnormal_white_adipose	1.33772535
48	MP0000049_abnormal_middle_ear	1.31516492
49	MP0005423_abnormal_somatic_nervous	1.29276666
50	MP0001486_abnormal_startle_reflex	1.28801054
51	MP0005499_abnormal_olfactory_system	1.27407904
52	MP0005394_taste/olfaction_phenotype	1.27407904
53	MP0004147_increased_porphyrin_level	1.25125024
54	MP0002638_abnormal_pupillary_reflex	1.24829042
55	MP0000685_abnormal_immune_system	1.24520800
56	MP0003698_abnormal_male_reproductive	1.24445728
57	MP0000566_synostosis	1.23620090
58	MP0002282_abnormal_trachea_morphology	1.23460393
59	MP0000955_abnormal_spinal_cord	1.21285327
60	MP0005645_abnormal_hypothalamus_physiol	1.20251498
61	MP0005389_reproductive_system_phenotype	1.19099370
62	MP0009764_decreased_sensitivity_to	1.15431597
63	MP0000372_irregular_coat_pigmentation	1.14658169
64	MP0001501_abnormal_sleep_pattern	1.12335560
65	MP0000427_abnormal_hair_cycle	1.11430371
66	MP0002138_abnormal_hepatobiliary_system	1.10558670
67	MP0009046_muscle_twitch	1.09418008
68	MP0001929_abnormal_gametogenesis	1.09183874
69	MP0005386_behavior/neurological_phenoty	1.06340637
70	MP0004924_abnormal_behavior	1.06340637
71	MP0001919_abnormal_reproductive_system	1.05825479
72	MP0002210_abnormal_sex_determination	1.05373935
73	MP0008775_abnormal_heart_ventricle	1.04230005
74	MP0001963_abnormal_hearing_physiology	1.04166524
75	MP0004742_abnormal_vestibular_system	1.04133808
76	MP0000026_abnormal_inner_ear	1.01833611
77	MP0002163_abnormal_gland_morphology	1.01324789
78	MP0003635_abnormal_synaptic_transmissio	1.00672277
79	MP0003183_abnormal_peptide_metabolism	1.00444712
80	MP0000230_abnormal_systemic_arterial	1.00370305
81	MP0002938_white_spotting	1.00339924
82	MP0003186_abnormal_redox_activity	1.00193472
83	MP0005195_abnormal_posterior_eye	0.99884843
84	MP0002752_abnormal_somatic_nervous	0.99752784
85	MP0002067_abnormal_sensory_capabilities	0.99726147
86	MP0003329_amyloid_beta_deposits	0.99580045
87	MP0003693_abnormal_embryo_hatching	0.96550217
88	MP0005253_abnormal_eye_physiology	0.95916847
89	MP0004130_abnormal_muscle_cell	0.94470474
90	MP0002064_seizures	0.94109252
91	MP0005379_endocrine/exocrine_gland_phen	0.93813346
92	MP0002184_abnormal_innervation	0.90991669
93	MP0003786_premature_aging	0.89286667
94	MP0005084_abnormal_gallbladder_morpholo	0.88548310
95	MP0002734_abnormal_mechanical_nocicepti	0.88423155
96	MP0003718_maternal_effect	0.88347418
97	MP0002102_abnormal_ear_morphology	0.84275535
98	MP0002882_abnormal_neuron_morphology	0.77842017
99	MP0001145_abnormal_male_reproductive	0.76746672
100	MP0002234_abnormal_pharynx_morphology	0.76690985

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.53093986
2	Molar tooth sign on MRI (HP:0002419)	4.29131268
3	Abnormality of midbrain morphology (HP:0002418)	4.29131268
4	Pancreatic cysts (HP:0001737)	4.18919353
5	Pancreatic fibrosis (HP:0100732)	3.96540521
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.80565930
7	Septo-optic dysplasia (HP:0100842)	3.79203122
8	Abnormality of the labia minora (HP:0012880)	3.67554316
9	Chronic hepatic failure (HP:0100626)	3.52928898
10	Acute necrotizing encephalopathy (HP:0006965)	3.40726691
11	True hermaphroditism (HP:0010459)	3.37774086
12	Absent thumb (HP:0009777)	3.31459539
13	Acute encephalopathy (HP:0006846)	3.27507803
14	Type II lissencephaly (HP:0007260)	3.24812506
15	Macrocytic anemia (HP:0001972)	3.14994819
16	Cystic liver disease (HP:0006706)	3.10955209
17	Abnormal mitochondria in muscle tissue (HP:0008316)	3.02362123
18	Mitochondrial inheritance (HP:0001427)	2.94111254
19	Nephronophthisis (HP:0000090)	2.93834193
20	Dyschromatopsia (HP:0007641)	2.93148873
21	Absent/shortened dynein arms (HP:0200106)	2.84799876
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.84799876
23	Colon cancer (HP:0003003)	2.78551515
24	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.75839974
25	Progressive macrocephaly (HP:0004481)	2.68836369
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.67223316
27	Abnormal number of erythroid precursors (HP:0012131)	2.66799796
28	Deep palmar crease (HP:0006191)	2.65210250
29	Abolished electroretinogram (ERG) (HP:0000550)	2.63376606
30	Asplenia (HP:0001746)	2.55580125
31	Stomatitis (HP:0010280)	2.55329345
32	Pallor (HP:0000980)	2.53248291
33	3-Methylglutaconic aciduria (HP:0003535)	2.50280278
34	Growth hormone deficiency (HP:0000824)	2.49299131
35	Absent septum pellucidum (HP:0001331)	2.49125787
36	Hepatocellular necrosis (HP:0001404)	2.46066904
37	Medial flaring of the eyebrow (HP:0010747)	2.43666807
38	Sclerocornea (HP:0000647)	2.43044211
39	Increased CSF lactate (HP:0002490)	2.38820198
40	Abnormality of the renal medulla (HP:0100957)	2.37176213
41	Anencephaly (HP:0002323)	2.35875831
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.32256395
43	Pendular nystagmus (HP:0012043)	2.31080877
44	Optic disc pallor (HP:0000543)	2.28166904
45	Optic nerve hypoplasia (HP:0000609)	2.24033982
46	Increased corneal curvature (HP:0100692)	2.20986004
47	Keratoconus (HP:0000563)	2.20986004
48	Broad-based gait (HP:0002136)	2.19351210
49	Lipid accumulation in hepatocytes (HP:0006561)	2.19179873
50	Hypoplasia of the radius (HP:0002984)	2.18197401
51	Type 2 muscle fiber atrophy (HP:0003554)	2.17734288
52	Abnormal biliary tract physiology (HP:0012439)	2.17478083
53	Bile duct proliferation (HP:0001408)	2.17478083
54	Oligodactyly (hands) (HP:0001180)	2.15821812
55	Abnormality of the aortic arch (HP:0012303)	2.13086343
56	Cerebral edema (HP:0002181)	2.11017588
57	Postaxial foot polydactyly (HP:0001830)	2.10558926
58	Anterior segment dysgenesis (HP:0007700)	2.08172427
59	Polyphagia (HP:0002591)	2.07983437
60	Increased hepatocellular lipid droplets (HP:0006565)	2.07906460
61	Tubulointerstitial nephritis (HP:0001970)	2.07901265
62	Hepatic necrosis (HP:0002605)	2.06643718
63	Cerebellar dysplasia (HP:0007033)	2.04944810
64	Abnormality of the renal collecting system (HP:0004742)	2.02645259
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00865954
66	Thyroid-stimulating hormone excess (HP:0002925)	2.00398269
67	Abnormal respiratory epithelium morphology (HP:0012253)	2.00250087
68	Abnormal respiratory motile cilium morphology (HP:0005938)	2.00250087
69	Increased serum lactate (HP:0002151)	2.00103795
70	Abnormal hemoglobin (HP:0011902)	1.99493640
71	Congenital stationary night blindness (HP:0007642)	1.98205269
72	Pachygyria (HP:0001302)	1.95283281
73	Impulsivity (HP:0100710)	1.95115815
74	Occipital encephalocele (HP:0002085)	1.94589455
75	Male pseudohermaphroditism (HP:0000037)	1.93847097
76	Hyperglycinuria (HP:0003108)	1.93006886
77	Chorioretinal atrophy (HP:0000533)	1.91133689
78	Abnormal ciliary motility (HP:0012262)	1.90981021
79	Hypoplasia of the brainstem (HP:0002365)	1.90624241
80	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.90624241
81	Abnormality of the septum pellucidum (HP:0007375)	1.90500767
82	IgG deficiency (HP:0004315)	1.90375848
83	Facial cleft (HP:0002006)	1.89698083
84	Ectopic kidney (HP:0000086)	1.89481461
85	Duplicated collecting system (HP:0000081)	1.88212825
86	Renal Fanconi syndrome (HP:0001994)	1.87734128
87	Decreased muscle mass (HP:0003199)	1.87285624
88	Oligodactyly (HP:0012165)	1.87170582
89	Depressed nasal ridge (HP:0000457)	1.87066594
90	Optic nerve coloboma (HP:0000588)	1.86333209
91	Gait imbalance (HP:0002141)	1.86187961
92	Forearm undergrowth (HP:0009821)	1.85388929
93	Congenital hepatic fibrosis (HP:0002612)	1.85338488
94	Stenosis of the external auditory canal (HP:0000402)	1.84600296
95	Myokymia (HP:0002411)	1.83229844
96	Anophthalmia (HP:0000528)	1.81603035
97	Flat capital femoral epiphysis (HP:0003370)	1.81281144
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79401852
99	Attenuation of retinal blood vessels (HP:0007843)	1.78853117
100	Testicular atrophy (HP:0000029)	1.77628556

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	3.20970411
2	DYRK2	2.88585654
3	VRK2	2.78366219
4	CDK19	2.77200294
5	WNK4	2.61665963
6	MAP4K2	2.41374619
7	EPHB2	2.32300935
8	ZAK	2.30537108
9	NUAK1	2.30533334
10	CAMKK2	2.13694918
11	MARK1	2.04599960
12	WNK3	2.04525156
13	GRK1	1.92557445
14	MAP2K2	1.88265817
15	LRRK2	1.84175402
16	PINK1	1.82625380
17	FRK	1.80409303
18	TYRO3	1.76784852
19	INSRR	1.76768639
20	ADRBK2	1.71250050
21	TXK	1.70795521
22	PLK2	1.60413632
23	PHKG2	1.57423620
24	PHKG1	1.57423620
25	MAP2K7	1.55425207
26	CAMK1	1.42238407
27	MAPK13	1.30605320
28	CAMK1G	1.28878767
29	CAMK1D	1.27850965
30	BMPR1B	1.23884665
31	BCKDK	1.21137034
32	VRK1	1.20854047
33	TAOK3	1.20748596
34	BRAF	1.20726770
35	PRKCQ	1.18012706
36	TIE1	1.16766485
37	WNK1	1.13607531
38	STK16	1.13536805
39	PRKCG	1.06229696
40	PAK6	1.03172386
41	DAPK2	1.01675666
42	MAP3K4	1.00963384
43	EIF2AK2	0.99479482
44	LIMK1	0.96617961
45	DAPK3	0.94308974
46	PIK3CA	0.93809097
47	OXSR1	0.93608227
48	CAMKK1	0.92947471
49	MAPKAPK3	0.91796805
50	PLK3	0.84888077
51	EPHA3	0.84751836
52	GRK5	0.84101200
53	NME2	0.81236369
54	PIM2	0.80144016
55	IKBKB	0.75865178
56	STK11	0.75304263
57	SGK223	0.75192491
58	SGK494	0.75192491
59	NME1	0.75023556
60	NTRK2	0.73895745
61	PRKCI	0.73025444
62	TLK1	0.71204009
63	CASK	0.69848546
64	ARAF	0.69642394
65	STK39	0.69427379
66	MINK1	0.69015442
67	ABL2	0.68858124
68	PRKCZ	0.68117022
69	RPS6KA6	0.67341602
70	DYRK1B	0.65831084
71	RPS6KA5	0.64535111
72	AKT3	0.63800705
73	PNCK	0.62851964
74	PRKCH	0.61859554
75	PRKACA	0.61680634
76	MAPK15	0.60616368
77	CAMK4	0.60143830
78	PRKCD	0.55479526
79	TAF1	0.54124600
80	NEK6	0.53216870
81	CSNK1G2	0.52891986
82	TEC	0.51975121
83	SGK1	0.47340710
84	CSNK2A2	0.47305242
85	RPS6KC1	0.45636129
86	RPS6KL1	0.45636129
87	RPS6KA1	0.45475465
88	ACVR1B	0.44332518
89	ADRBK1	0.43610968
90	PRKD3	0.40043115
91	ITK	0.38016983
92	OBSCN	0.37356157
93	PKN1	0.36795425
94	SYK	0.35692616
95	PRKACG	0.35401279
96	MUSK	0.35326653
97	PRKG1	0.34831976
98	CDK14	0.32096685
99	PRKCA	0.31429919
100	IKBKE	0.30335326

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.03761925
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.08100549
3	Parkinsons disease_Homo sapiens_hsa05012	3.49032907
4	RNA polymerase_Homo sapiens_hsa03020	2.83950752
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.78168298
6	Huntingtons disease_Homo sapiens_hsa05016	2.50951528
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.39937011
8	Alzheimers disease_Homo sapiens_hsa05010	2.35340718
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.26092863
10	Proteasome_Homo sapiens_hsa03050	2.14959513
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.09820051
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.02134095
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99991097
14	Sulfur relay system_Homo sapiens_hsa04122	1.90409768
15	Basal transcription factors_Homo sapiens_hsa03022	1.88790995
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.52224321
17	Phototransduction_Homo sapiens_hsa04744	1.51363087
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.36738041
19	RNA degradation_Homo sapiens_hsa03018	1.36605117
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.32780142
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.32443947
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31221727
23	Nicotine addiction_Homo sapiens_hsa05033	1.30853524
24	Protein export_Homo sapiens_hsa03060	1.29176988
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27526316
26	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25907385
27	RNA transport_Homo sapiens_hsa03013	1.20403609
28	Butanoate metabolism_Homo sapiens_hsa00650	1.18348212
29	Morphine addiction_Homo sapiens_hsa05032	1.17751638
30	Caffeine metabolism_Homo sapiens_hsa00232	1.14291777
31	Homologous recombination_Homo sapiens_hsa03440	1.12594993
32	Asthma_Homo sapiens_hsa05310	1.10779209
33	Primary immunodeficiency_Homo sapiens_hsa05340	1.07906285
34	Olfactory transduction_Homo sapiens_hsa04740	1.06857614
35	Fat digestion and absorption_Homo sapiens_hsa04975	1.06190143
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05927353
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97139601
38	Fanconi anemia pathway_Homo sapiens_hsa03460	0.93701030
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92205796
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.89980311
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.89400021
42	One carbon pool by folate_Homo sapiens_hsa00670	0.86265508
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.84995128
44	Propanoate metabolism_Homo sapiens_hsa00640	0.84756774
45	Purine metabolism_Homo sapiens_hsa00230	0.82707284
46	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81719849
47	Mismatch repair_Homo sapiens_hsa03430	0.81344645
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.80393730
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79859350
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79850663
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77229566
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.75211988
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74913437
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74219089
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73043947
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.72986875
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.67776773
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66761169
59	Metabolic pathways_Homo sapiens_hsa01100	0.62949281
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.60637376
61	Allograft rejection_Homo sapiens_hsa05330	0.60347417
62	Salivary secretion_Homo sapiens_hsa04970	0.59855937
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58589057
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57159100
65	Fatty acid degradation_Homo sapiens_hsa00071	0.57116244
66	Circadian entrainment_Homo sapiens_hsa04713	0.56606587
67	Retinol metabolism_Homo sapiens_hsa00830	0.56543535
68	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.55851409
69	Insulin secretion_Homo sapiens_hsa04911	0.55629413
70	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55235268
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.55088970
72	Serotonergic synapse_Homo sapiens_hsa04726	0.54857837
73	Peroxisome_Homo sapiens_hsa04146	0.54238433
74	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.53089607
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.52224074
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49813437
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47602368
78	GABAergic synapse_Homo sapiens_hsa04727	0.44256741
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43574415
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42645886
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40468037
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.40413452
83	Taste transduction_Homo sapiens_hsa04742	0.38708771
84	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.38143092
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.35709165
86	Spliceosome_Homo sapiens_hsa03040	0.34097998
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.31375043
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.31057366
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.28559713
90	Mineral absorption_Homo sapiens_hsa04978	0.28258099
91	Rheumatoid arthritis_Homo sapiens_hsa05323	0.28166665
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27639881
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25951075
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.25529427
95	Non-homologous end-joining_Homo sapiens_hsa03450	0.25374591
96	Axon guidance_Homo sapiens_hsa04360	0.24286427
97	DNA replication_Homo sapiens_hsa03030	0.24166999
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.20576776
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.20551508
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.19906686

RPS4XP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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