RPS4XP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of multicellular organism growth (GO:0040015)9.52479490
2regulation of establishment of cell polarity (GO:2000114)8.71877562
3cytoplasmic mRNA processing body assembly (GO:0033962)8.61367483
4regulation of MHC class I biosynthetic process (GO:0045343)8.36615989
5sex differentiation (GO:0007548)8.17905733
6negative regulation of type 2 immune response (GO:0002829)7.66772798
7regulation of establishment or maintenance of cell polarity (GO:0032878)7.06133764
8sterol catabolic process (GO:0016127)6.67914492
9cholesterol catabolic process (GO:0006707)6.67914492
10regulation of interleukin-13 production (GO:0032656)6.38568770
11kynurenine metabolic process (GO:0070189)6.26125651
12positive regulation of vasculogenesis (GO:2001214)6.24345669
13ADP metabolic process (GO:0046031)6.13271001
14stress granule assembly (GO:0034063)6.09405009
15indole-containing compound catabolic process (GO:0042436)5.97142845
16indolalkylamine catabolic process (GO:0046218)5.97142845
17tryptophan catabolic process (GO:0006569)5.97142845
18cerebellar Purkinje cell differentiation (GO:0021702)5.93811411
19alternative mRNA splicing, via spliceosome (GO:0000380)5.56839550
20regulation of interleukin-5 production (GO:0032674)5.54256295
21nucleoside diphosphate catabolic process (GO:0009134)5.51515683
22negative regulation of receptor-mediated endocytosis (GO:0048261)5.21791664
23tryptophan metabolic process (GO:0006568)5.04491620
24regulation of vasculogenesis (GO:2001212)4.95508428
25centrosome duplication (GO:0051298)4.65871843
26bile acid biosynthetic process (GO:0006699)4.61662735
27indolalkylamine metabolic process (GO:0006586)4.48228182
28lipid particle organization (GO:0034389)4.42365817
29regulation of metalloenzyme activity (GO:0048552)4.38657814
30regulation of action potential (GO:0098900)4.31704252
31L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.09532637
32negative regulation of mast cell activation (GO:0033004)3.93190305
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.89034536
34amine catabolic process (GO:0009310)3.88427361
35cellular biogenic amine catabolic process (GO:0042402)3.88427361
36acrosome assembly (GO:0001675)3.87833928
37negative regulation of endothelial cell apoptotic process (GO:2000352)3.84235496
38regulation of triglyceride catabolic process (GO:0010896)3.78204593
39neuronal action potential propagation (GO:0019227)3.74403888
40aromatic amino acid family catabolic process (GO:0009074)3.71574995
41neural tube formation (GO:0001841)3.57716322
42synaptic transmission, cholinergic (GO:0007271)3.57493907
43central nervous system projection neuron axonogenesis (GO:0021952)3.53108243
44purine ribonucleoside diphosphate metabolic process (GO:0009179)3.52289667
45purine nucleoside diphosphate metabolic process (GO:0009135)3.52289667
46central nervous system neuron axonogenesis (GO:0021955)3.47895751
47somite rostral/caudal axis specification (GO:0032525)3.47538314
48NAD biosynthetic process (GO:0009435)3.46994563
49piRNA metabolic process (GO:0034587)3.40402074
50regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.40133753
51lipid translocation (GO:0034204)3.38223121
52phospholipid translocation (GO:0045332)3.38223121
53response to X-ray (GO:0010165)3.37322145
54L-methionine salvage (GO:0071267)3.37065983
55L-methionine biosynthetic process (GO:0071265)3.37065983
56amino acid salvage (GO:0043102)3.37065983
57cellular ketone body metabolic process (GO:0046950)3.35405147
58estrogen biosynthetic process (GO:0006703)3.33636228
59L-fucose catabolic process (GO:0042355)3.31031631
60fucose catabolic process (GO:0019317)3.31031631
61L-fucose metabolic process (GO:0042354)3.31031631
62auditory receptor cell stereocilium organization (GO:0060088)3.20052293
63seminiferous tubule development (GO:0072520)3.16510761
64negative regulation of endothelial cell proliferation (GO:0001937)3.14819940
65steroid catabolic process (GO:0006706)3.13210630
66protein autoprocessing (GO:0016540)3.12058247
67ketone body metabolic process (GO:1902224)3.09865015
68regulation of gene silencing by RNA (GO:0060966)3.09422056
69regulation of posttranscriptional gene silencing (GO:0060147)3.09422056
70regulation of gene silencing by miRNA (GO:0060964)3.09422056
71one-carbon compound transport (GO:0019755)3.07262285
72indole-containing compound metabolic process (GO:0042430)3.07076602
73negative regulation of T cell differentiation (GO:0045581)3.04210533
74regulation of sequestering of triglyceride (GO:0010889)3.03791749
75positive regulation of triglyceride biosynthetic process (GO:0010867)2.98347406
76detection of light stimulus involved in visual perception (GO:0050908)2.97904061
77detection of light stimulus involved in sensory perception (GO:0050962)2.97904061
78positive regulation of heat generation (GO:0031652)2.96244680
79behavioral response to ethanol (GO:0048149)2.95547601
80positive regulation of fatty acid beta-oxidation (GO:0032000)2.93801264
81negative regulation of organ growth (GO:0046621)2.92612962
82aromatic amino acid family metabolic process (GO:0009072)2.89969709
83regulation of receptor internalization (GO:0002090)2.88174739
84killing of cells of other organism (GO:0031640)2.87716400
85disruption of cells of other organism (GO:0044364)2.87716400
86metallo-sulfur cluster assembly (GO:0031163)2.84107465
87iron-sulfur cluster assembly (GO:0016226)2.84107465
88cell differentiation in hindbrain (GO:0021533)2.83758746
89regulation of superoxide metabolic process (GO:0090322)2.82292417
90phosphatidylglycerol biosynthetic process (GO:0006655)2.82181602
91regulation of collateral sprouting (GO:0048670)2.81508526
92histone H3-K4 trimethylation (GO:0080182)2.80501657
93methionine biosynthetic process (GO:0009086)2.80296632
94DNA methylation involved in gamete generation (GO:0043046)2.79052690
95cardiolipin metabolic process (GO:0032048)2.78237251
96regulation of sarcomere organization (GO:0060297)2.77960575
97adult walking behavior (GO:0007628)2.75635897
98DNA demethylation (GO:0080111)2.75377157
99benzene-containing compound metabolic process (GO:0042537)2.74127614
100regulation of memory T cell differentiation (GO:0043380)10.4079223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.57110611
2VDR_22108803_ChIP-Seq_LS180_Human4.22235695
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.89326516
4GBX2_23144817_ChIP-Seq_PC3_Human3.38040933
5TAF15_26573619_Chip-Seq_HEK293_Human3.26345497
6IGF1R_20145208_ChIP-Seq_DFB_Human2.98113008
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74024520
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.73837546
9EZH2_22144423_ChIP-Seq_EOC_Human2.60599518
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45073642
11BCAT_22108803_ChIP-Seq_LS180_Human2.43121363
12ZNF274_21170338_ChIP-Seq_K562_Hela2.42865236
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42198428
14ER_23166858_ChIP-Seq_MCF-7_Human2.38744627
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28566352
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27308125
17FUS_26573619_Chip-Seq_HEK293_Human2.09723343
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00419156
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96412549
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95890139
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.90440050
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89691163
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.88507845
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86988616
25P300_19829295_ChIP-Seq_ESCs_Human1.82204126
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74189410
27STAT3_23295773_ChIP-Seq_U87_Human1.65216193
28AR_25329375_ChIP-Seq_VCAP_Human1.63525180
29NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61499592
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60000604
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58895199
32TCF4_23295773_ChIP-Seq_U87_Human1.56640352
33SMAD4_21799915_ChIP-Seq_A2780_Human1.55225964
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52234146
35CBP_20019798_ChIP-Seq_JUKART_Human1.46654158
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46654158
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.45947397
38EWS_26573619_Chip-Seq_HEK293_Human1.43743114
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42674553
40OCT1_27270436_Chip-Seq_PROSTATE_Human1.42557273
41CDX2_22108803_ChIP-Seq_LS180_Human1.42493115
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42137778
43DROSHA_22980978_ChIP-Seq_HELA_Human1.37961905
44SMAD4_21741376_ChIP-Seq_EPCs_Human1.37182077
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34742635
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34146589
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.32476338
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32476338
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31889767
50TCF4_22108803_ChIP-Seq_LS180_Human1.31490956
51RUNX2_22187159_ChIP-Seq_PCA_Human1.30560556
52IRF1_19129219_ChIP-ChIP_H3396_Human1.29140302
53KDM2B_26808549_Chip-Seq_REH_Human1.28507731
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26994979
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25721595
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25588828
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23492704
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.22813681
59REST_21632747_ChIP-Seq_MESCs_Mouse1.21727071
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21051311
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20320005
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.19700401
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.17741184
64TP53_22573176_ChIP-Seq_HFKS_Human1.17699860
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.15472765
66TP53_18474530_ChIP-ChIP_U2OS_Human1.14245971
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.14102655
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13752238
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.13414923
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.13023570
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12562477
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12562477
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11467174
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10721429
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10211094
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.10031281
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.09551828
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07065909
79NCOR_22424771_ChIP-Seq_293T_Human1.06307422
80TBL1_22424771_ChIP-Seq_293T_Human1.05836446
81RXR_22108803_ChIP-Seq_LS180_Human1.05016181
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04156813
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03787688
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03372581
85AR_20517297_ChIP-Seq_VCAP_Human1.02848018
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02828198
87TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01373621
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.01279489
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.99002316
90OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98900274
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98897493
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97490067
93CJUN_26792858_Chip-Seq_BT549_Human0.97472087
94AR_21572438_ChIP-Seq_LNCaP_Human0.96982877
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95498828
96NMYC_18555785_Chip-Seq_ESCs_Mouse0.95339337
97P53_22387025_ChIP-Seq_ESCs_Mouse0.94888729
98AHR_22903824_ChIP-Seq_MCF-7_Human0.93051383
99NANOG_19829295_ChIP-Seq_ESCs_Human0.92899254
100SOX2_19829295_ChIP-Seq_ESCs_Human0.92899254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003252_abnormal_bile_duct5.63201914
2MP0003011_delayed_dark_adaptation5.12790667
3MP0002736_abnormal_nociception_after4.71435315
4MP0000569_abnormal_digit_pigmentation4.53595883
5MP0001968_abnormal_touch/_nociception3.86575038
6MP0001986_abnormal_taste_sensitivity3.38664749
7MP0003195_calcinosis2.69431940
8MP0000371_diluted_coat_color2.57877864
9MP0001501_abnormal_sleep_pattern2.43495038
10MP0005646_abnormal_pituitary_gland2.42922758
11MP0002234_abnormal_pharynx_morphology2.34434028
12MP0005551_abnormal_eye_electrophysiolog2.29661155
13MP0009745_abnormal_behavioral_response2.29504907
14MP0003950_abnormal_plasma_membrane2.24903444
15MP0002837_dystrophic_cardiac_calcinosis2.19215333
16MP0005253_abnormal_eye_physiology2.18588437
17MP0002102_abnormal_ear_morphology2.11106192
18MP0009046_muscle_twitch1.93540596
19MP0003646_muscle_fatigue1.91129287
20MP0000427_abnormal_hair_cycle1.87090629
21MP0005647_abnormal_sex_gland1.81822984
22MP0006072_abnormal_retinal_apoptosis1.77981472
23MP0010386_abnormal_urinary_bladder1.73766976
24MP0003718_maternal_effect1.61900406
25MP0002272_abnormal_nervous_system1.52963816
26MP0005085_abnormal_gallbladder_physiolo1.51333342
27MP0005171_absent_coat_pigmentation1.50305612
28MP0003137_abnormal_impulse_conducting1.44050949
29MP0002876_abnormal_thyroid_physiology1.43758759
30MP0005310_abnormal_salivary_gland1.42924637
31MP0001486_abnormal_startle_reflex1.42867008
32MP0002138_abnormal_hepatobiliary_system1.41301360
33MP0005174_abnormal_tail_pigmentation1.41147404
34MP0000383_abnormal_hair_follicle1.38445058
35MP0004130_abnormal_muscle_cell1.37049167
36MP0005410_abnormal_fertilization1.33675065
37MP0005075_abnormal_melanosome_morpholog1.33274239
38MP0002064_seizures1.27395616
39MP0006035_abnormal_mitochondrial_morpho1.24999200
40MP0004043_abnormal_pH_regulation1.21552315
41MP0003186_abnormal_redox_activity1.17291679
42MP0003890_abnormal_embryonic-extraembry1.14927398
43MP0004145_abnormal_muscle_electrophysio1.14213311
44MP0002282_abnormal_trachea_morphology1.11942485
45MP0002733_abnormal_thermal_nociception1.09535503
46MP0005334_abnormal_fat_pad1.08512980
47MP0000372_irregular_coat_pigmentation1.06324846
48MP0004147_increased_porphyrin_level1.05905328
49MP0002693_abnormal_pancreas_physiology1.05017566
50MP0004924_abnormal_behavior1.04725366
51MP0005386_behavior/neurological_phenoty1.04725366
52MP0003119_abnormal_digestive_system1.04576430
53MP0002075_abnormal_coat/hair_pigmentati1.03348833
54MP0001764_abnormal_homeostasis1.01385432
55MP0001666_abnormal_nutrient_absorption1.00075399
56MP0002067_abnormal_sensory_capabilities0.94906427
57MP0008877_abnormal_DNA_methylation0.92680686
58MP0008872_abnormal_physiological_respon0.90626454
59MP0000631_abnormal_neuroendocrine_gland0.90003137
60MP0000653_abnormal_sex_gland0.89012078
61MP0003880_abnormal_central_pattern0.88709459
62MP0001970_abnormal_pain_threshold0.88426324
63MP0002160_abnormal_reproductive_system0.88331461
64MP0006276_abnormal_autonomic_nervous0.88171779
65MP0004381_abnormal_hair_follicle0.88002000
66MP0004885_abnormal_endolymph0.87127673
67MP0002638_abnormal_pupillary_reflex0.86885866
68MP0003136_yellow_coat_color0.86017947
69MP0002229_neurodegeneration0.81173950
70MP0001324_abnormal_eye_pigmentation0.80272589
71MP0002163_abnormal_gland_morphology0.80230367
72MP0002118_abnormal_lipid_homeostasis0.78968615
73MP0003635_abnormal_synaptic_transmissio0.78806467
74MP0004742_abnormal_vestibular_system0.77367641
75MP0005083_abnormal_biliary_tract0.76939150
76MP0009384_cardiac_valve_regurgitation0.73681931
77MP0005395_other_phenotype0.72751166
78MP0003172_abnormal_lysosome_physiology0.72676512
79MP0001485_abnormal_pinna_reflex0.71002716
80MP0003935_abnormal_craniofacial_develop0.70821901
81MP0005636_abnormal_mineral_homeostasis0.70626669
82MP0002572_abnormal_emotion/affect_behav0.70224018
83MP0001145_abnormal_male_reproductive0.70051812
84MP0005670_abnormal_white_adipose0.69573635
85MP0006036_abnormal_mitochondrial_physio0.69346841
86MP0002938_white_spotting0.68412067
87MP0008875_abnormal_xenobiotic_pharmacok0.67877868
88MP0009250_abnormal_appendicular_skeleto0.67160255
89MP0008961_abnormal_basal_metabolism0.67051849
90MP0001963_abnormal_hearing_physiology0.66424715
91MP0005367_renal/urinary_system_phenotyp0.66015447
92MP0000516_abnormal_urinary_system0.66015447
93MP0005645_abnormal_hypothalamus_physiol0.65779438
94MP0003698_abnormal_male_reproductive0.65654562
95MP0001664_abnormal_digestion0.64064915
96MP0002752_abnormal_somatic_nervous0.62637819
97MP0010678_abnormal_skin_adnexa0.62595543
98MP0000749_muscle_degeneration0.62017090
99MP0001944_abnormal_pancreas_morphology0.61745994
100MP0002751_abnormal_autonomic_nervous0.61473817

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)9.73465051
2Dysmetric saccades (HP:0000641)8.46874364
3Action tremor (HP:0002345)8.17283435
4Progressive cerebellar ataxia (HP:0002073)7.46907449
5Prostate neoplasm (HP:0100787)6.99127329
6Gaze-evoked nystagmus (HP:0000640)5.84380147
7Pendular nystagmus (HP:0012043)5.19159687
8Absence seizures (HP:0002121)5.18271382
9Abnormality of the hepatic vasculature (HP:0006707)4.74549740
10Urinary bladder sphincter dysfunction (HP:0002839)4.66166668
11Dialeptic seizures (HP:0011146)4.42002535
12Focal seizures (HP:0007359)4.40377866
13Dysdiadochokinesis (HP:0002075)4.19625617
14Postural instability (HP:0002172)4.08160464
15Severe visual impairment (HP:0001141)3.99394303
16Postural tremor (HP:0002174)3.98741625
17Slow saccadic eye movements (HP:0000514)3.79803629
18Hypochromic microcytic anemia (HP:0004840)3.77101353
19Hyperventilation (HP:0002883)3.74724770
20Impaired vibratory sensation (HP:0002495)3.71579147
21Abnormality of the prostate (HP:0008775)3.66171928
22Abnormality of macular pigmentation (HP:0008002)3.57099810
23Focal motor seizures (HP:0011153)3.55650096
24Limb ataxia (HP:0002070)3.50449680
25Impaired smooth pursuit (HP:0007772)3.36731987
26Pancreatic cysts (HP:0001737)3.07031952
27Increased corneal curvature (HP:0100692)2.86613430
28Keratoconus (HP:0000563)2.86613430
29Impaired proprioception (HP:0010831)2.76646428
30Chorioretinal atrophy (HP:0000533)2.60444078
31Pancreatic fibrosis (HP:0100732)2.58175365
32True hermaphroditism (HP:0010459)2.57290435
33Retinitis pigmentosa (HP:0000510)2.52634675
34Febrile seizures (HP:0002373)2.51726860
35Fair hair (HP:0002286)2.44732338
36Oculomotor apraxia (HP:0000657)2.40576700
37Clumsiness (HP:0002312)2.38727276
38Vitreoretinal degeneration (HP:0000655)2.36824892
39Bilateral microphthalmos (HP:0007633)2.30866185
40Congenital sensorineural hearing impairment (HP:0008527)2.29252465
41Abnormality of ocular smooth pursuit (HP:0000617)2.26976711
42Areflexia of lower limbs (HP:0002522)2.26152393
43Absent/shortened dynein arms (HP:0200106)2.25744558
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.25744558
45Molar tooth sign on MRI (HP:0002419)2.25492155
46Abnormality of midbrain morphology (HP:0002418)2.25492155
47Absent speech (HP:0001344)2.24162552
48Postnatal microcephaly (HP:0005484)2.23945961
49Proximal tubulopathy (HP:0000114)2.20326620
50Abolished electroretinogram (ERG) (HP:0000550)2.18905418
51Atonic seizures (HP:0010819)2.17950853
52Bony spicule pigmentary retinopathy (HP:0007737)2.17451174
53Abnormality of male internal genitalia (HP:0000022)2.16949674
54Attenuation of retinal blood vessels (HP:0007843)2.16083006
55Abnormality of vision evoked potentials (HP:0000649)2.15450849
56Congenital stationary night blindness (HP:0007642)2.13199798
57Severe Myopia (HP:0011003)2.13146938
58Nephronophthisis (HP:0000090)2.12264015
59Abnormal respiratory motile cilium physiology (HP:0012261)2.12241474
60Abnormality of the renal cortex (HP:0011035)2.11853987
61Hypochromic anemia (HP:0001931)2.10776843
62Inability to walk (HP:0002540)2.09761840
63Biliary tract neoplasm (HP:0100574)2.09013553
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.08514863
65Abnormal ciliary motility (HP:0012262)2.02432968
66Protruding tongue (HP:0010808)2.00678603
67Decreased muscle mass (HP:0003199)1.97411165
68Rib fusion (HP:0000902)1.97039382
69Hemiparesis (HP:0001269)1.91944756
70Decreased central vision (HP:0007663)1.89961221
71Hypoplasia of the fovea (HP:0007750)1.88955804
72Aplasia/Hypoplasia of the fovea (HP:0008060)1.88955804
73Sclerocornea (HP:0000647)1.84833187
74Generalized hypopigmentation of hair (HP:0011358)1.83302006
75Abnormality of the renal medulla (HP:0100957)1.81119267
76Aplasia/Hypoplasia of the macula (HP:0008059)1.79310296
77Facial diplegia (HP:0001349)1.78100695
78Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77667322
79Cystic liver disease (HP:0006706)1.77374652
80Disproportionate short-trunk short stature (HP:0003521)1.77012218
81Portal hypertension (HP:0001409)1.76745571
82Macular degeneration (HP:0000608)1.75329842
83Tinnitus (HP:0000360)1.73984347
84Tubular atrophy (HP:0000092)1.70842441
85Abnormality of saccadic eye movements (HP:0000570)1.70150854
86Broad-based gait (HP:0002136)1.68542139
87Horizontal nystagmus (HP:0000666)1.68467803
88Renal cortical cysts (HP:0000803)1.67004790
89Hypoproteinemia (HP:0003075)1.66346702
90Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65835263
91Hyperthyroidism (HP:0000836)1.65279140
92Chromosomal breakage induced by crosslinking agents (HP:0003221)1.64695078
93Aplasia/Hypoplasia affecting the retina (HP:0008061)1.64580604
94Chromsome breakage (HP:0040012)1.64041417
95Hyperglycinuria (HP:0003108)1.60272816
96Medial flaring of the eyebrow (HP:0010747)1.60098653
97Abnormality of alanine metabolism (HP:0010916)1.59322703
98Hyperalaninemia (HP:0003348)1.59322703
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59322703
100Progressive inability to walk (HP:0002505)1.58060510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK198.70230682
2FRK7.91353891
3OXSR15.17908320
4ACVR1B3.09326477
5BMPR1B2.83380832
6TNK22.44816669
7GRK12.30830494
8MAP3K71.98734162
9ADRBK21.93022591
10PINK11.79888340
11MKNK21.66816191
12ZAK1.51997880
13NEK11.48556530
14BCR1.47987882
15NUAK11.46850511
16FER1.44974236
17INSRR1.41364236
18WNK31.34134554
19TXK1.33909847
20MAP4K21.29420757
21STK31.23479141
22STK38L1.23305185
23CASK1.19004892
24TGFBR11.15669691
25MAPK131.01620620
26TAOK30.99177657
27MKNK10.97510813
28RPS6KB20.94818705
29VRK20.89690828
30STK380.87298458
31TAF10.82578082
32ADRBK10.79497018
33STK110.78121311
34TRIM280.70378255
35MAPKAPK50.66465146
36TNIK0.57743377
37ALK0.55799495
38PTK2B0.55053847
39PRKAA20.54053736
40WNK40.52313078
41DAPK20.52011411
42MAP3K40.51527857
43BRSK20.50825231
44TIE10.50481870
45PAK30.49233167
46CSNK1G20.49158982
47PRKCE0.46862056
48PLK20.46610657
49PRKCG0.46310745
50CHEK20.45993860
51MUSK0.45708986
52MARK10.45026844
53TEC0.44851881
54CSNK1G10.43784160
55PIK3CG0.43023503
56CAMKK20.42493861
57NTRK30.41617077
58STK390.40565236
59PLK40.38923423
60VRK10.37216100
61CSNK1A1L0.35934942
62LATS10.34967380
63CSNK1G30.34939067
64GRK50.33377094
65NEK20.32566075
66PIK3CA0.31902165
67CAMK2A0.30107300
68EIF2AK30.29859700
69PDK10.29709248
70CSNK1A10.28521963
71OBSCN0.26775544
72MAP2K70.26195818
73PRKG10.25219579
74AKT30.24973106
75EPHA40.24593915
76ERBB30.23624631
77PRKD30.22387893
78ERBB20.22314071
79MELK0.21966203
80PRKAA10.21159133
81MAP2K10.20637178
82CHEK10.20256269
83PRKACA0.19817811
84PDPK10.19792063
85BCKDK0.19774302
86PIM20.19726082
87PKN10.19660798
88CDK50.16777585
89JAK20.16315811
90CSNK1D0.15726134
91MATK0.15610800
92PRKCA0.15119988
93MAP2K60.12965482
94RPS6KB10.12874152
95FGFR20.12864483
96PRKCI0.12852747
97PLK30.12716223
98IGF1R0.12138801
99ABL10.10791528
100CDK180.09550337

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001207.07233363
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.40038533
3Butanoate metabolism_Homo sapiens_hsa006502.55566079
4Tryptophan metabolism_Homo sapiens_hsa003802.41105730
5Caffeine metabolism_Homo sapiens_hsa002322.40323729
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.32052102
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26097414
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.12201544
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06354257
10Fatty acid biosynthesis_Homo sapiens_hsa000612.06218847
11Propanoate metabolism_Homo sapiens_hsa006402.02845075
12Ether lipid metabolism_Homo sapiens_hsa005652.02521668
13Retinol metabolism_Homo sapiens_hsa008302.00832303
14Olfactory transduction_Homo sapiens_hsa047402.00153762
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98723899
16Linoleic acid metabolism_Homo sapiens_hsa005911.98575138
17RNA polymerase_Homo sapiens_hsa030201.94955210
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94925149
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80256565
20Phototransduction_Homo sapiens_hsa047441.79947474
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78886842
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63109985
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37094520
24Nicotine addiction_Homo sapiens_hsa050331.34082472
25ABC transporters_Homo sapiens_hsa020101.29277253
26Nitrogen metabolism_Homo sapiens_hsa009101.25515173
27Taste transduction_Homo sapiens_hsa047421.24716206
28Chemical carcinogenesis_Homo sapiens_hsa052041.22340415
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21627232
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.15002870
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14451371
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.12651734
33Homologous recombination_Homo sapiens_hsa034401.10722778
34Salivary secretion_Homo sapiens_hsa049701.08514107
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03786060
36Morphine addiction_Homo sapiens_hsa050320.99627537
37Fatty acid degradation_Homo sapiens_hsa000710.99368681
38Purine metabolism_Homo sapiens_hsa002300.89943197
39Glutamatergic synapse_Homo sapiens_hsa047240.89629923
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88895813
41Fanconi anemia pathway_Homo sapiens_hsa034600.88177167
42Glycerolipid metabolism_Homo sapiens_hsa005610.86751027
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85625419
44beta-Alanine metabolism_Homo sapiens_hsa004100.84137403
45PPAR signaling pathway_Homo sapiens_hsa033200.82775822
46Arachidonic acid metabolism_Homo sapiens_hsa005900.80601293
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80528803
48Sphingolipid metabolism_Homo sapiens_hsa006000.80320908
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79278566
50Ovarian steroidogenesis_Homo sapiens_hsa049130.76953414
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.75835875
52Peroxisome_Homo sapiens_hsa041460.75806656
53Fatty acid metabolism_Homo sapiens_hsa012120.75121401
54Renin-angiotensin system_Homo sapiens_hsa046140.75104746
55Long-term depression_Homo sapiens_hsa047300.74503270
56N-Glycan biosynthesis_Homo sapiens_hsa005100.73859199
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.71816177
58Gastric acid secretion_Homo sapiens_hsa049710.69766204
59Non-homologous end-joining_Homo sapiens_hsa034500.68690423
60Dorso-ventral axis formation_Homo sapiens_hsa043200.64561410
61cAMP signaling pathway_Homo sapiens_hsa040240.64401138
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63627950
63Circadian entrainment_Homo sapiens_hsa047130.62921036
64Pyrimidine metabolism_Homo sapiens_hsa002400.61113948
65Calcium signaling pathway_Homo sapiens_hsa040200.60197050
66Circadian rhythm_Homo sapiens_hsa047100.59810308
67Serotonergic synapse_Homo sapiens_hsa047260.59269465
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58449198
69Melanoma_Homo sapiens_hsa052180.57613397
70GABAergic synapse_Homo sapiens_hsa047270.56142141
71Basal transcription factors_Homo sapiens_hsa030220.54266762
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53357267
73Glutathione metabolism_Homo sapiens_hsa004800.52286680
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.52118678
75Insulin secretion_Homo sapiens_hsa049110.51457243
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50379743
77Metabolic pathways_Homo sapiens_hsa011000.49941568
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49592993
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.45865568
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.44872786
81Starch and sucrose metabolism_Homo sapiens_hsa005000.43901125
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.43294087
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41492733
84Pyruvate metabolism_Homo sapiens_hsa006200.41436647
85Histidine metabolism_Homo sapiens_hsa003400.38644553
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35547400
87Fat digestion and absorption_Homo sapiens_hsa049750.31696147
88Renin secretion_Homo sapiens_hsa049240.31098405
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30754313
90Oxytocin signaling pathway_Homo sapiens_hsa049210.29212812
91Rap1 signaling pathway_Homo sapiens_hsa040150.28852297
92Ras signaling pathway_Homo sapiens_hsa040140.27272717
93Mineral absorption_Homo sapiens_hsa049780.25681130
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25130963
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23916992
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21851009
97Pancreatic secretion_Homo sapiens_hsa049720.21346118
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21024776
99Arginine and proline metabolism_Homo sapiens_hsa003300.20400111
100RNA degradation_Homo sapiens_hsa030180.19755028

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