ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.65721206
2	DNA deamination (GO:0045006)	5.93706161
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.38500617
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.24018013
5	ATP synthesis coupled proton transport (GO:0015986)	5.24018013
6	viral transcription (GO:0019083)	5.23794299
7	translational termination (GO:0006415)	5.01908709
8	cytidine deamination (GO:0009972)	4.78754269
9	cytidine metabolic process (GO:0046087)	4.78754269
10	cytidine catabolic process (GO:0006216)	4.78754269
11	translational elongation (GO:0006414)	4.57723011
12	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.49922307
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.45745045
14	cotranslational protein targeting to membrane (GO:0006613)	4.35463576
15	protein targeting to ER (GO:0045047)	4.33053107
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.29107909
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.15549538
18	protein localization to endoplasmic reticulum (GO:0070972)	4.12318275
19	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.03545097
20	respiratory electron transport chain (GO:0022904)	3.97958266
21	ribosomal large subunit biogenesis (GO:0042273)	3.96930951
22	electron transport chain (GO:0022900)	3.95570906
23	protein neddylation (GO:0045116)	3.93831084
24	viral life cycle (GO:0019058)	3.72529124
25	ribosomal small subunit biogenesis (GO:0042274)	3.70062241
26	cellular protein complex disassembly (GO:0043624)	3.69175368
27	maturation of SSU-rRNA (GO:0030490)	3.63515857
28	protein complex biogenesis (GO:0070271)	3.61911562
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.61284573
30	NADH dehydrogenase complex assembly (GO:0010257)	3.61284573
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.61284573
32	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.60884754
33	translational initiation (GO:0006413)	3.57737111
34	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.43727135
35	translation (GO:0006412)	3.42989585
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.23811873
37	response to pheromone (GO:0019236)	3.23702811
38	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.20743160
39	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.18475574
40	chaperone-mediated protein transport (GO:0072321)	3.10992147
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.06682236
42	ATP biosynthetic process (GO:0006754)	3.03009071
43	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.99963256
44	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.99457246
45	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.98430312
46	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.95243020
47	protein complex disassembly (GO:0043241)	2.94387936
48	GPI anchor biosynthetic process (GO:0006506)	2.94076225
49	hydrogen ion transmembrane transport (GO:1902600)	2.93481310
50	GTP biosynthetic process (GO:0006183)	2.90318174
51	GPI anchor metabolic process (GO:0006505)	2.88226995
52	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.86571149
53	termination of RNA polymerase III transcription (GO:0006386)	2.86571149
54	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.83681756
55	macromolecular complex disassembly (GO:0032984)	2.83573699
56	protein targeting to membrane (GO:0006612)	2.82543460
57	actin nucleation (GO:0045010)	2.81626510
58	proteasome assembly (GO:0043248)	2.79086218
59	positive regulation of interleukin-17 production (GO:0032740)	2.77638382
60	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.77156394
61	behavioral response to nicotine (GO:0035095)	2.73449274
62	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.73089736
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.73089736
64	preassembly of GPI anchor in ER membrane (GO:0016254)	2.72748077
65	proton transport (GO:0015992)	2.72220995
66	regulation of B cell receptor signaling pathway (GO:0050855)	2.69803880
67	hydrogen transport (GO:0006818)	2.68471083
68	sequestering of actin monomers (GO:0042989)	2.68272385
69	positive regulation of interleukin-8 secretion (GO:2000484)	2.68044623
70	positive regulation of prostaglandin secretion (GO:0032308)	2.67001517
71	cellular component biogenesis (GO:0044085)	2.65605882
72	mRNA catabolic process (GO:0006402)	2.64832385
73	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.64790899
74	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.64389441
75	regulation of cellular amino acid metabolic process (GO:0006521)	2.64342440
76	positive regulation of defense response to virus by host (GO:0002230)	2.63759919
77	mast cell activation (GO:0045576)	2.62896665
78	pseudouridine synthesis (GO:0001522)	2.62672396
79	negative regulation of heart rate (GO:0010459)	2.61413483
80	regulation of regulatory T cell differentiation (GO:0045589)	2.58408976
81	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.58092229
82	water-soluble vitamin biosynthetic process (GO:0042364)	2.58028643
83	negative regulation of T cell differentiation in thymus (GO:0033085)	2.57721248
84	metallo-sulfur cluster assembly (GO:0031163)	2.57497659
85	iron-sulfur cluster assembly (GO:0016226)	2.57497659
86	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.57020543
87	platelet dense granule organization (GO:0060155)	2.56908480
88	positive regulation of calcium-mediated signaling (GO:0050850)	2.56819838
89	regulation of interleukin-8 secretion (GO:2000482)	2.55586339
90	response to interferon-beta (GO:0035456)	2.54662248
91	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.48901319
92	deoxyribose phosphate catabolic process (GO:0046386)	2.48735703
93	regulation of activation of Janus kinase activity (GO:0010533)	2.48639303
94	negative regulation of mast cell activation (GO:0033004)	2.48453391
95	negative regulation of T cell apoptotic process (GO:0070233)	2.47976662
96	positive thymic T cell selection (GO:0045059)	2.47904864
97	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.46939376
98	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.46691074
99	peptidyl-histidine modification (GO:0018202)	2.45756697
100	kynurenine metabolic process (GO:0070189)	2.45349006

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.52906218
2	VDR_22108803_ChIP-Seq_LS180_Human	3.50111444
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.38820765
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.33582632
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.06088376
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.93837882
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.84688482
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.83090958
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.80918216
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.64528661
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46411457
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42282243
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.39518429
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.37922319
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.36996488
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25525237
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.21553364
18	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.20872912
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13796764
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.03737760
21	FUS_26573619_Chip-Seq_HEK293_Human	1.99743097
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88926073
23	EWS_26573619_Chip-Seq_HEK293_Human	1.79334982
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.74906258
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.74449940
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67762205
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65503016
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.64751425
29	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.63402503
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62881753
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.57831284
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55236111
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53713856
34	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.50199376
35	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.45199650
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44718797
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.40815254
38	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.38195134
39	AR_20517297_ChIP-Seq_VCAP_Human	1.37542669
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.37289467
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35992850
42	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.35579510
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.34302101
44	GATA3_26560356_Chip-Seq_TH2_Human	1.31603723
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.31235936
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.30969952
47	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28578572
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26014975
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26014975
50	P300_19829295_ChIP-Seq_ESCs_Human	1.23752298
51	MYB_26560356_Chip-Seq_TH2_Human	1.23374993
52	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22871816
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19066770
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19066770
55	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18544007
56	NCOR_22424771_ChIP-Seq_293T_Human	1.15774904
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13810812
58	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12892591
59	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12658761
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12519195
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11983472
62	CIITA_25753668_ChIP-Seq_RAJI_Human	1.11171776
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10652171
64	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10383994
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09892126
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09763666
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09201391
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08321957
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07761571
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.07761571
71	ERG_20517297_ChIP-Seq_VCAP_Human	1.07564110
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05951325
73	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05124963
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04218360
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04087280
76	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03823478
77	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02484603
78	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.02100130
79	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00839691
80	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00413405
81	TTF2_22483619_ChIP-Seq_HELA_Human	1.00068567
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96982172
83	MYC_19829295_ChIP-Seq_ESCs_Human	0.96893064
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96804320
85	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.96726808
86	RUNX_20019798_ChIP-Seq_JUKART_Human	0.96692623
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.96112961
88	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.95391846
89	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.95236201
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94000435
91	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91059170
92	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90194105
93	GATA3_27048872_Chip-Seq_THYMUS_Human	0.89487701
94	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.89348860
95	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.88850384
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.88825232
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.88743256
98	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.87646301
99	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.87375725
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.86973009

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.77094583
2	MP0009379_abnormal_foot_pigmentation	3.42695990
3	MP0001835_abnormal_antigen_presentation	3.31527231
4	MP0006072_abnormal_retinal_apoptosis	2.73703878
5	MP0006292_abnormal_olfactory_placode	2.68106176
6	MP0005646_abnormal_pituitary_gland	2.33769420
7	MP0003646_muscle_fatigue	1.96302955
8	MP0009785_altered_susceptibility_to	1.95973588
9	MP0000372_irregular_coat_pigmentation	1.94166104
10	MP0008875_abnormal_xenobiotic_pharmacok	1.89701228
11	MP0004145_abnormal_muscle_electrophysio	1.85285593
12	MP0002148_abnormal_hypersensitivity_rea	1.82390461
13	MP0002166_altered_tumor_susceptibility	1.78017253
14	MP0005645_abnormal_hypothalamus_physiol	1.76375750
15	MP0005377_hearing/vestibular/ear_phenot	1.75611068
16	MP0003878_abnormal_ear_physiology	1.75611068
17	MP0001800_abnormal_humoral_immune	1.75420816
18	MP0002876_abnormal_thyroid_physiology	1.70381707
19	MP0005389_reproductive_system_phenotype	1.69909284
20	MP0002102_abnormal_ear_morphology	1.69852148
21	MP0005551_abnormal_eye_electrophysiolog	1.62821875
22	MP0008872_abnormal_physiological_respon	1.62622875
23	MP0009333_abnormal_splenocyte_physiolog	1.59410125
24	MP0001873_stomach_inflammation	1.58052572
25	MP0001919_abnormal_reproductive_system	1.57515006
26	MP0005253_abnormal_eye_physiology	1.53869403
27	MP0002138_abnormal_hepatobiliary_system	1.51868437
28	MP0000685_abnormal_immune_system	1.49626123
29	MP0004885_abnormal_endolymph	1.49270535
30	MP0005075_abnormal_melanosome_morpholog	1.49064996
31	MP0001986_abnormal_taste_sensitivity	1.48557056
32	MP0002006_tumorigenesis	1.48312672
33	MP0005000_abnormal_immune_tolerance	1.47594211
34	MP0009764_decreased_sensitivity_to	1.46531094
35	MP0002163_abnormal_gland_morphology	1.45998099
36	MP0001905_abnormal_dopamine_level	1.45709862
37	MP0005084_abnormal_gallbladder_morpholo	1.45338974
38	MP0003787_abnormal_imprinting	1.44134911
39	MP0002723_abnormal_immune_serum	1.43184088
40	MP0001968_abnormal_touch/_nociception	1.40700829
41	MP0006276_abnormal_autonomic_nervous	1.40135926
42	MP0003763_abnormal_thymus_physiology	1.39388821
43	MP0002160_abnormal_reproductive_system	1.38333621
44	MP0004147_increased_porphyrin_level	1.37494710
45	MP0004142_abnormal_muscle_tone	1.37213987
46	MP0003866_abnormal_defecation	1.37003617
47	MP0008877_abnormal_DNA_methylation	1.35573635
48	MP0003806_abnormal_nucleotide_metabolis	1.30687033
49	MP0002095_abnormal_skin_pigmentation	1.30495333
50	MP0002420_abnormal_adaptive_immunity	1.29561352
51	MP0002837_dystrophic_cardiac_calcinosis	1.29116368
52	MP0001819_abnormal_immune_cell	1.28273834
53	MP0000631_abnormal_neuroendocrine_gland	1.27169433
54	MP0002277_abnormal_respiratory_mucosa	1.26258347
55	MP0002452_abnormal_antigen_presenting	1.25319180
56	MP0002736_abnormal_nociception_after	1.20318891
57	MP0002638_abnormal_pupillary_reflex	1.15711635
58	MP0000049_abnormal_middle_ear	1.14603624
59	MP0005387_immune_system_phenotype	1.13395105
60	MP0001790_abnormal_immune_system	1.13395105
61	MP0008995_early_reproductive_senescence	1.12184508
62	MP0003567_abnormal_fetal_cardiomyocyte	1.11449411
63	MP0002272_abnormal_nervous_system	1.11040657
64	MP0005025_abnormal_response_to	1.09509677
65	MP0001485_abnormal_pinna_reflex	1.09331841
66	MP0006036_abnormal_mitochondrial_physio	1.07744906
67	MP0003786_premature_aging	1.03792703
68	MP0003011_delayed_dark_adaptation	1.03507554
69	MP0000716_abnormal_immune_system	1.02779542
70	MP0003283_abnormal_digestive_organ	1.01325065
71	MP0002398_abnormal_bone_marrow	0.99992035
72	MP0001764_abnormal_homeostasis	0.98240060
73	MP0001970_abnormal_pain_threshold	0.94614220
74	MP0010155_abnormal_intestine_physiology	0.94336178
75	MP0003880_abnormal_central_pattern	0.93073439
76	MP0002735_abnormal_chemical_nociception	0.91748075
77	MP0003252_abnormal_bile_duct	0.91669163
78	MP0001765_abnormal_ion_homeostasis	0.91620851
79	MP0001188_hyperpigmentation	0.89186709
80	MP0009745_abnormal_behavioral_response	0.88901546
81	MP0000689_abnormal_spleen_morphology	0.87710328
82	MP0001529_abnormal_vocalization	0.85672410
83	MP0008789_abnormal_olfactory_epithelium	0.85195134
84	MP0002733_abnormal_thermal_nociception	0.84947286
85	MP0000703_abnormal_thymus_morphology	0.83205091
86	MP0004134_abnormal_chest_morphology	0.80867342
87	MP0004742_abnormal_vestibular_system	0.80019283
88	MP0000681_abnormal_thyroid_gland	0.79652796
89	MP0005636_abnormal_mineral_homeostasis	0.79259368
90	MP0005410_abnormal_fertilization	0.75859778
91	MP0002429_abnormal_blood_cell	0.75505756
92	MP0001845_abnormal_inflammatory_respons	0.74266228
93	MP0001963_abnormal_hearing_physiology	0.73969897
94	MP0001501_abnormal_sleep_pattern	0.72630019
95	MP0002722_abnormal_immune_system	0.72247846
96	MP0008469_abnormal_protein_level	0.72009614
97	MP0005379_endocrine/exocrine_gland_phen	0.71790099
98	MP0005195_abnormal_posterior_eye	0.71055338
99	MP0001486_abnormal_startle_reflex	0.69441527
100	MP0009765_abnormal_xenobiotic_induced	0.66732418

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.47282198
2	Acute necrotizing encephalopathy (HP:0006965)	4.41663259
3	Mitochondrial inheritance (HP:0001427)	4.26333107
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.87514864
5	Progressive macrocephaly (HP:0004481)	3.77133457
6	Increased CSF lactate (HP:0002490)	3.72469264
7	Acute encephalopathy (HP:0006846)	3.54988768
8	Hepatocellular necrosis (HP:0001404)	3.45776898
9	Congenital stationary night blindness (HP:0007642)	3.41314979
10	3-Methylglutaconic aciduria (HP:0003535)	3.33215329
11	Pancreatic cysts (HP:0001737)	3.33212287
12	Increased hepatocellular lipid droplets (HP:0006565)	3.31777221
13	Hepatic necrosis (HP:0002605)	3.25986877
14	Abolished electroretinogram (ERG) (HP:0000550)	3.23188102
15	Elevated erythrocyte sedimentation rate (HP:0003565)	3.20743776
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.19721833
17	Abnormality of midbrain morphology (HP:0002418)	3.17963103
18	Molar tooth sign on MRI (HP:0002419)	3.17963103
19	IgG deficiency (HP:0004315)	3.14311307
20	Abnormality of cells of the erythroid lineage (HP:0012130)	3.10113248
21	Hypoproteinemia (HP:0003075)	3.08875500
22	True hermaphroditism (HP:0010459)	3.06495840
23	Cerebral edema (HP:0002181)	2.99271067
24	Lipid accumulation in hepatocytes (HP:0006561)	2.98843582
25	Reticulocytopenia (HP:0001896)	2.91333272
26	Severe combined immunodeficiency (HP:0004430)	2.88394238
27	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.87594332
28	Aplastic anemia (HP:0001915)	2.85970110
29	Pancreatic fibrosis (HP:0100732)	2.84673387
30	Abnormal number of erythroid precursors (HP:0012131)	2.82760247
31	Renal Fanconi syndrome (HP:0001994)	2.82092499
32	Optic disc pallor (HP:0000543)	2.73850431
33	Absent/shortened dynein arms (HP:0200106)	2.73190681
34	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.73190681
35	Thyroiditis (HP:0100646)	2.71293213
36	Abnormality of B cell number (HP:0010975)	2.65979329
37	B lymphocytopenia (HP:0010976)	2.63125678
38	Attenuation of retinal blood vessels (HP:0007843)	2.61531861
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.59883410
40	Decreased central vision (HP:0007663)	2.58119773
41	Abnormality of the prostate (HP:0008775)	2.56281555
42	Stenosis of the external auditory canal (HP:0000402)	2.52588319
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.51981475
44	Increased serum lactate (HP:0002151)	2.50724486
45	Increased intramyocellular lipid droplets (HP:0012240)	2.49876809
46	Constricted visual fields (HP:0001133)	2.48337226
47	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.40891535
48	Pendular nystagmus (HP:0012043)	2.37104972
49	Panhypogammaglobulinemia (HP:0003139)	2.35059124
50	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.34036231
51	Nephronophthisis (HP:0000090)	2.33447953
52	Exertional dyspnea (HP:0002875)	2.32365297
53	Macrocytic anemia (HP:0001972)	2.32179397
54	Lactic acidosis (HP:0003128)	2.28052606
55	Stomatitis (HP:0010280)	2.25565065
56	Generalized aminoaciduria (HP:0002909)	2.23842502
57	T lymphocytopenia (HP:0005403)	2.23842050
58	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.22283099
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.19718780
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.19718780
61	Congenital, generalized hypertrichosis (HP:0004540)	2.14304918
62	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.10569135
63	Abnormality of T cell number (HP:0011839)	2.08757466
64	Pallor (HP:0000980)	2.08140474
65	Respiratory failure (HP:0002878)	2.06240915
66	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.06128421
67	Type 2 muscle fiber atrophy (HP:0003554)	2.05332918
68	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02918003
69	Increased muscle lipid content (HP:0009058)	2.01250701
70	Abnormal respiratory epithelium morphology (HP:0012253)	1.99931426
71	Abnormal respiratory motile cilium morphology (HP:0005938)	1.99931426
72	Asplenia (HP:0001746)	1.99740706
73	Combined immunodeficiency (HP:0005387)	1.98636264
74	Palpebral edema (HP:0100540)	1.98258796
75	Abnormality of urine glucose concentration (HP:0011016)	1.94768217
76	Glycosuria (HP:0003076)	1.94768217
77	Cystic liver disease (HP:0006706)	1.93783565
78	Exercise intolerance (HP:0003546)	1.89931844
79	Lethargy (HP:0001254)	1.88741479
80	Abnormal ciliary motility (HP:0012262)	1.87858197
81	Abnormality of renal resorption (HP:0011038)	1.87296636
82	Hypoplasia of the uterus (HP:0000013)	1.86639705
83	Abnormality of the renal medulla (HP:0100957)	1.86636657
84	Colon cancer (HP:0003003)	1.84076540
85	Sclerocornea (HP:0000647)	1.84041904
86	Leukodystrophy (HP:0002415)	1.80715446
87	Abnormality of the renal cortex (HP:0011035)	1.79675241
88	Furrowed tongue (HP:0000221)	1.78337470
89	Type II lissencephaly (HP:0007260)	1.76969246
90	Abnormality of T cells (HP:0002843)	1.76458224
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76391540
92	Abnormality of alanine metabolism (HP:0010916)	1.72065196
93	Hyperalaninemia (HP:0003348)	1.72065196
94	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.72065196
95	Renal cortical cysts (HP:0000803)	1.71292918
96	Agammaglobulinemia (HP:0004432)	1.70605552
97	Absent thumb (HP:0009777)	1.69558074
98	Severe visual impairment (HP:0001141)	1.68055648
99	Muscle fiber atrophy (HP:0100295)	1.67957049
100	Chronic sinusitis (HP:0011109)	1.67410325

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.14305599
2	CDK19	3.40405147
3	BCKDK	3.03616342
4	ZAK	2.84645124
5	STK16	2.83836709
6	TAOK3	2.65229350
7	MAP4K2	2.64432152
8	ADRBK2	2.59615963
9	TLK1	2.52388197
10	NUAK1	2.46178874
11	KDR	2.44185429
12	GRK1	2.24153223
13	TESK2	2.21668329
14	FRK	2.11134457
15	VRK2	2.03475465
16	MAP3K12	1.99692556
17	NME2	1.76290799
18	TIE1	1.76005730
19	BMPR2	1.75877511
20	TEC	1.62915464
21	MAP4K1	1.62473579
22	ITK	1.50204311
23	LIMK1	1.44357675
24	VRK1	1.36580970
25	SCYL2	1.35950068
26	KIT	1.29837649
27	DYRK2	1.27306070
28	CSNK1G3	1.18072909
29	MST4	1.16845666
30	WNK4	1.16446793
31	SYK	1.13386272
32	PINK1	1.11367390
33	WNK3	1.06437384
34	CSNK1G2	1.05026697
35	DAPK1	1.03708215
36	BMPR1B	1.00273305
37	IKBKB	0.98916075
38	CAMKK2	0.98828772
39	GRK6	0.97205808
40	MYLK	0.96831246
41	BTK	0.96084298
42	CSNK1A1L	0.94046602
43	OXSR1	0.92793408
44	PIK3CG	0.91681908
45	CSF1R	0.91102207
46	PHKG1	0.89594357
47	PHKG2	0.89594357
48	INSRR	0.85566349
49	MAP2K7	0.84313157
50	OBSCN	0.84075988
51	LCK	0.83839498
52	CSNK1G1	0.83800019
53	PRKCQ	0.81923528
54	TNK2	0.81866488
55	RPS6KA5	0.80644061
56	FES	0.77863439
57	TNIK	0.77243821
58	PASK	0.76964672
59	LYN	0.76208899
60	EIF2AK3	0.75195730
61	DAPK3	0.72446737
62	JAK3	0.65358519
63	TAF1	0.64110055
64	PIK3CA	0.62639647
65	MAPK13	0.61526814
66	ERBB3	0.61118291
67	ILK	0.60001650
68	CDK8	0.58558175
69	MATK	0.57363914
70	MUSK	0.55652432
71	ADRBK1	0.55613118
72	IKBKE	0.55382173
73	DAPK2	0.54305194
74	RPS6KA4	0.53591362
75	MAP3K4	0.53115669
76	GRK7	0.52863922
77	FLT3	0.49448127
78	PRKCE	0.49373722
79	PIM1	0.49017673
80	CAMKK1	0.45248937
81	AURKA	0.44756312
82	IGF1R	0.43931611
83	PRKACA	0.42374818
84	CSNK2A1	0.37263321
85	CSNK2A2	0.36266336
86	PRKCA	0.35541411
87	GRK5	0.33212009
88	TRIM28	0.32703151
89	ABL1	0.30538845
90	PLK4	0.30326963
91	PRKCD	0.30202992
92	CCNB1	0.29829728
93	PRKCH	0.28151273
94	PRKCG	0.28124915
95	CSNK1A1	0.27865197
96	STK39	0.27300852
97	MAP2K6	0.27088790
98	SRPK1	0.24868256
99	TBK1	0.24665941
100	TYRO3	0.23595107

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.54062607
2	Asthma_Homo sapiens_hsa05310	3.97731446
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.70621907
4	Proteasome_Homo sapiens_hsa03050	3.32506650
5	Allograft rejection_Homo sapiens_hsa05330	3.25480781
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.24567749
7	Parkinsons disease_Homo sapiens_hsa05012	3.04103807
8	Graft-versus-host disease_Homo sapiens_hsa05332	3.01614680
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.81052155
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.59617414
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.59346674
12	RNA polymerase_Homo sapiens_hsa03020	2.10649610
13	Alzheimers disease_Homo sapiens_hsa05010	2.02721910
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98649079
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.90681036
16	Huntingtons disease_Homo sapiens_hsa05016	1.87574640
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.84863852
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.76968787
19	Protein export_Homo sapiens_hsa03060	1.72238297
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.68976024
21	Phototransduction_Homo sapiens_hsa04744	1.68669422
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.66004915
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.51183743
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43937296
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33662975
26	RNA degradation_Homo sapiens_hsa03018	1.27863640
27	Caffeine metabolism_Homo sapiens_hsa00232	1.27127735
28	Viral myocarditis_Homo sapiens_hsa05416	1.22402404
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.18417118
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.07260090
31	Homologous recombination_Homo sapiens_hsa03440	1.04393268
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03993517
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.01240483
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.98772567
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97777131
36	Nitrogen metabolism_Homo sapiens_hsa00910	0.96534593
37	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.87630342
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.87282400
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83931985
40	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83507997
41	Purine metabolism_Homo sapiens_hsa00230	0.82207351
42	Peroxisome_Homo sapiens_hsa04146	0.81660364
43	Olfactory transduction_Homo sapiens_hsa04740	0.80208438
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79609374
45	One carbon pool by folate_Homo sapiens_hsa00670	0.78955690
46	Spliceosome_Homo sapiens_hsa03040	0.78724285
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.77774000
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.76808281
49	Regulation of autophagy_Homo sapiens_hsa04140	0.72243219
50	Retinol metabolism_Homo sapiens_hsa00830	0.70235810
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68777989
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67012629
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63874517
54	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.63258572
55	Nucleotide excision repair_Homo sapiens_hsa03420	0.63032562
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62649178
57	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.62453307
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.61841926
59	Butanoate metabolism_Homo sapiens_hsa00650	0.61437909
60	Nicotine addiction_Homo sapiens_hsa05033	0.60967118
61	Leishmaniasis_Homo sapiens_hsa05140	0.60728722
62	Propanoate metabolism_Homo sapiens_hsa00640	0.60661994
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59244232
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57390866
65	Basal transcription factors_Homo sapiens_hsa03022	0.57245477
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.56216403
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55497971
68	Morphine addiction_Homo sapiens_hsa05032	0.54431549
69	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.54063426
70	Taste transduction_Homo sapiens_hsa04742	0.53427541
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52644537
72	RNA transport_Homo sapiens_hsa03013	0.51824429
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51211345
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49425901
75	DNA replication_Homo sapiens_hsa03030	0.47862073
76	Sulfur metabolism_Homo sapiens_hsa00920	0.47742395
77	Mismatch repair_Homo sapiens_hsa03430	0.45324696
78	Metabolic pathways_Homo sapiens_hsa01100	0.44318861
79	Salivary secretion_Homo sapiens_hsa04970	0.42434642
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.39122597
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38158303
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31907234
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31375797
84	Serotonergic synapse_Homo sapiens_hsa04726	0.29125412
85	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.28948687
86	Herpes simplex infection_Homo sapiens_hsa05168	0.28817430
87	Circadian entrainment_Homo sapiens_hsa04713	0.28178614
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27708418
89	Base excision repair_Homo sapiens_hsa03410	0.27278547
90	Glutathione metabolism_Homo sapiens_hsa00480	0.25541711
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.25272904
92	GABAergic synapse_Homo sapiens_hsa04727	0.25257601
93	Sulfur relay system_Homo sapiens_hsa04122	0.20581157
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.19576072
95	Measles_Homo sapiens_hsa05162	0.16179269
96	Tuberculosis_Homo sapiens_hsa05152	0.15977684
97	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.14698946
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.12990923
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.12917956
100	Selenocompound metabolism_Homo sapiens_hsa00450	0.12598078

RPS4XP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »