RPS4XP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.65721206
2DNA deamination (GO:0045006)5.93706161
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.38500617
4ATP synthesis coupled proton transport (GO:0015986)5.24018013
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.24018013
6viral transcription (GO:0019083)5.23794299
7translational termination (GO:0006415)5.01908709
8cytidine metabolic process (GO:0046087)4.78754269
9cytidine catabolic process (GO:0006216)4.78754269
10cytidine deamination (GO:0009972)4.78754269
11translational elongation (GO:0006414)4.57723011
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.49922307
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.45745045
14cotranslational protein targeting to membrane (GO:0006613)4.35463576
15protein targeting to ER (GO:0045047)4.33053107
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.29107909
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.15549538
18protein localization to endoplasmic reticulum (GO:0070972)4.12318275
19pyrimidine ribonucleoside catabolic process (GO:0046133)4.03545097
20respiratory electron transport chain (GO:0022904)3.97958266
21ribosomal large subunit biogenesis (GO:0042273)3.96930951
22electron transport chain (GO:0022900)3.95570906
23protein neddylation (GO:0045116)3.93831084
24viral life cycle (GO:0019058)3.72529124
25ribosomal small subunit biogenesis (GO:0042274)3.70062241
26cellular protein complex disassembly (GO:0043624)3.69175368
27maturation of SSU-rRNA (GO:0030490)3.63515857
28protein complex biogenesis (GO:0070271)3.61911562
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.61284573
30NADH dehydrogenase complex assembly (GO:0010257)3.61284573
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61284573
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60884754
33translational initiation (GO:0006413)3.57737111
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43727135
35translation (GO:0006412)3.42989585
36mitochondrial respiratory chain complex assembly (GO:0033108)3.23811873
37response to pheromone (GO:0019236)3.23702811
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20743160
39positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.18475574
40chaperone-mediated protein transport (GO:0072321)3.10992147
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.06682236
42ATP biosynthetic process (GO:0006754)3.03009071
43purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99963256
44purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99457246
45regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.98430312
46Arp2/3 complex-mediated actin nucleation (GO:0034314)2.95243020
47protein complex disassembly (GO:0043241)2.94387936
48GPI anchor biosynthetic process (GO:0006506)2.94076225
49hydrogen ion transmembrane transport (GO:1902600)2.93481310
50GTP biosynthetic process (GO:0006183)2.90318174
51GPI anchor metabolic process (GO:0006505)2.88226995
52termination of RNA polymerase III transcription (GO:0006386)2.86571149
53transcription elongation from RNA polymerase III promoter (GO:0006385)2.86571149
54nuclear-transcribed mRNA catabolic process (GO:0000956)2.83681756
55macromolecular complex disassembly (GO:0032984)2.83573699
56protein targeting to membrane (GO:0006612)2.82543460
57actin nucleation (GO:0045010)2.81626510
58proteasome assembly (GO:0043248)2.79086218
59positive regulation of interleukin-17 production (GO:0032740)2.77638382
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77156394
61behavioral response to nicotine (GO:0035095)2.73449274
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73089736
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73089736
64preassembly of GPI anchor in ER membrane (GO:0016254)2.72748077
65proton transport (GO:0015992)2.72220995
66regulation of B cell receptor signaling pathway (GO:0050855)2.69803880
67hydrogen transport (GO:0006818)2.68471083
68sequestering of actin monomers (GO:0042989)2.68272385
69positive regulation of interleukin-8 secretion (GO:2000484)2.68044623
70positive regulation of prostaglandin secretion (GO:0032308)2.67001517
71cellular component biogenesis (GO:0044085)2.65605882
72mRNA catabolic process (GO:0006402)2.64832385
73ribonucleoside triphosphate biosynthetic process (GO:0009201)2.64790899
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.64389441
75regulation of cellular amino acid metabolic process (GO:0006521)2.64342440
76positive regulation of defense response to virus by host (GO:0002230)2.63759919
77mast cell activation (GO:0045576)2.62896665
78pseudouridine synthesis (GO:0001522)2.62672396
79negative regulation of heart rate (GO:0010459)2.61413483
80regulation of regulatory T cell differentiation (GO:0045589)2.58408976
81positive regulation of alpha-beta T cell proliferation (GO:0046641)2.58092229
82water-soluble vitamin biosynthetic process (GO:0042364)2.58028643
83negative regulation of T cell differentiation in thymus (GO:0033085)2.57721248
84iron-sulfur cluster assembly (GO:0016226)2.57497659
85metallo-sulfur cluster assembly (GO:0031163)2.57497659
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57020543
87platelet dense granule organization (GO:0060155)2.56908480
88positive regulation of calcium-mediated signaling (GO:0050850)2.56819838
89regulation of interleukin-8 secretion (GO:2000482)2.55586339
90response to interferon-beta (GO:0035456)2.54662248
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48901319
92deoxyribose phosphate catabolic process (GO:0046386)2.48735703
93regulation of activation of Janus kinase activity (GO:0010533)2.48639303
94negative regulation of mast cell activation (GO:0033004)2.48453391
95negative regulation of T cell apoptotic process (GO:0070233)2.47976662
96positive thymic T cell selection (GO:0045059)2.47904864
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46939376
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.46691074
99peptidyl-histidine modification (GO:0018202)2.45756697
100kynurenine metabolic process (GO:0070189)2.45349006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.52906218
2VDR_22108803_ChIP-Seq_LS180_Human3.50111444
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.38820765
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.33582632
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06088376
6EZH2_22144423_ChIP-Seq_EOC_Human2.93837882
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.84688482
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83090958
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80918216
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64528661
11IGF1R_20145208_ChIP-Seq_DFB_Human2.46411457
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42282243
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39518429
14ZNF274_21170338_ChIP-Seq_K562_Hela2.37922319
15VDR_23849224_ChIP-Seq_CD4+_Human2.36996488
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.25525237
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.21553364
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20872912
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13796764
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03737760
21FUS_26573619_Chip-Seq_HEK293_Human1.99743097
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88926073
23EWS_26573619_Chip-Seq_HEK293_Human1.79334982
24FOXP3_21729870_ChIP-Seq_TREG_Human1.74906258
25TAF15_26573619_Chip-Seq_HEK293_Human1.74449940
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.67762205
27ELK1_19687146_ChIP-ChIP_HELA_Human1.65503016
28MYC_18940864_ChIP-ChIP_HL60_Human1.64751425
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63402503
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62881753
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57831284
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55236111
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53713856
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50199376
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.45199650
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44718797
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40815254
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.38195134
39AR_20517297_ChIP-Seq_VCAP_Human1.37542669
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37289467
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35992850
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35579510
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.34302101
44GATA3_26560356_Chip-Seq_TH2_Human1.31603723
45ER_23166858_ChIP-Seq_MCF-7_Human1.31235936
46TP53_22573176_ChIP-Seq_HFKS_Human1.30969952
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28578572
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26014975
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.26014975
50P300_19829295_ChIP-Seq_ESCs_Human1.23752298
51MYB_26560356_Chip-Seq_TH2_Human1.23374993
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22871816
53NANOG_19829295_ChIP-Seq_ESCs_Human1.19066770
54SOX2_19829295_ChIP-Seq_ESCs_Human1.19066770
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18544007
56NCOR_22424771_ChIP-Seq_293T_Human1.15774904
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13810812
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12892591
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.12658761
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12519195
61IRF1_19129219_ChIP-ChIP_H3396_Human1.11983472
62CIITA_25753668_ChIP-Seq_RAJI_Human1.11171776
63NANOG_20526341_ChIP-Seq_ESCs_Human1.10652171
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10383994
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09892126
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.09763666
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09201391
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08321957
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07761571
70CBP_20019798_ChIP-Seq_JUKART_Human1.07761571
71ERG_20517297_ChIP-Seq_VCAP_Human1.07564110
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05951325
73TAF2_19829295_ChIP-Seq_ESCs_Human1.05124963
74RNF2_27304074_Chip-Seq_NSC_Mouse1.04218360
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.04087280
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03823478
77HTT_18923047_ChIP-ChIP_STHdh_Human1.02484603
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02100130
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00839691
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00413405
81TTF2_22483619_ChIP-Seq_HELA_Human1.00068567
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96982172
83MYC_19829295_ChIP-Seq_ESCs_Human0.96893064
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.96804320
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96726808
86RUNX_20019798_ChIP-Seq_JUKART_Human0.96692623
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96112961
88EED_16625203_ChIP-ChIP_MESCs_Mouse0.95391846
89MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95236201
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94000435
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91059170
92P53_21459846_ChIP-Seq_SAOS-2_Human0.90194105
93GATA3_27048872_Chip-Seq_THYMUS_Human0.89487701
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89348860
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88850384
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88825232
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88743256
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87646301
99ELK1_22589737_ChIP-Seq_MCF10A_Human0.87375725
100EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86973009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.77094583
2MP0009379_abnormal_foot_pigmentation3.42695990
3MP0001835_abnormal_antigen_presentation3.31527231
4MP0006072_abnormal_retinal_apoptosis2.73703878
5MP0006292_abnormal_olfactory_placode2.68106176
6MP0005646_abnormal_pituitary_gland2.33769420
7MP0003646_muscle_fatigue1.96302955
8MP0009785_altered_susceptibility_to1.95973588
9MP0000372_irregular_coat_pigmentation1.94166104
10MP0008875_abnormal_xenobiotic_pharmacok1.89701228
11MP0004145_abnormal_muscle_electrophysio1.85285593
12MP0002148_abnormal_hypersensitivity_rea1.82390461
13MP0002166_altered_tumor_susceptibility1.78017253
14MP0005645_abnormal_hypothalamus_physiol1.76375750
15MP0003878_abnormal_ear_physiology1.75611068
16MP0005377_hearing/vestibular/ear_phenot1.75611068
17MP0001800_abnormal_humoral_immune1.75420816
18MP0002876_abnormal_thyroid_physiology1.70381707
19MP0005389_reproductive_system_phenotype1.69909284
20MP0002102_abnormal_ear_morphology1.69852148
21MP0005551_abnormal_eye_electrophysiolog1.62821875
22MP0008872_abnormal_physiological_respon1.62622875
23MP0009333_abnormal_splenocyte_physiolog1.59410125
24MP0001873_stomach_inflammation1.58052572
25MP0001919_abnormal_reproductive_system1.57515006
26MP0005253_abnormal_eye_physiology1.53869403
27MP0002138_abnormal_hepatobiliary_system1.51868437
28MP0000685_abnormal_immune_system1.49626123
29MP0004885_abnormal_endolymph1.49270535
30MP0005075_abnormal_melanosome_morpholog1.49064996
31MP0001986_abnormal_taste_sensitivity1.48557056
32MP0002006_tumorigenesis1.48312672
33MP0005000_abnormal_immune_tolerance1.47594211
34MP0009764_decreased_sensitivity_to1.46531094
35MP0002163_abnormal_gland_morphology1.45998099
36MP0001905_abnormal_dopamine_level1.45709862
37MP0005084_abnormal_gallbladder_morpholo1.45338974
38MP0003787_abnormal_imprinting1.44134911
39MP0002723_abnormal_immune_serum1.43184088
40MP0001968_abnormal_touch/_nociception1.40700829
41MP0006276_abnormal_autonomic_nervous1.40135926
42MP0003763_abnormal_thymus_physiology1.39388821
43MP0002160_abnormal_reproductive_system1.38333621
44MP0004147_increased_porphyrin_level1.37494710
45MP0004142_abnormal_muscle_tone1.37213987
46MP0003866_abnormal_defecation1.37003617
47MP0008877_abnormal_DNA_methylation1.35573635
48MP0003806_abnormal_nucleotide_metabolis1.30687033
49MP0002095_abnormal_skin_pigmentation1.30495333
50MP0002420_abnormal_adaptive_immunity1.29561352
51MP0002837_dystrophic_cardiac_calcinosis1.29116368
52MP0001819_abnormal_immune_cell1.28273834
53MP0000631_abnormal_neuroendocrine_gland1.27169433
54MP0002277_abnormal_respiratory_mucosa1.26258347
55MP0002452_abnormal_antigen_presenting1.25319180
56MP0002736_abnormal_nociception_after1.20318891
57MP0002638_abnormal_pupillary_reflex1.15711635
58MP0000049_abnormal_middle_ear1.14603624
59MP0001790_abnormal_immune_system1.13395105
60MP0005387_immune_system_phenotype1.13395105
61MP0008995_early_reproductive_senescence1.12184508
62MP0003567_abnormal_fetal_cardiomyocyte1.11449411
63MP0002272_abnormal_nervous_system1.11040657
64MP0005025_abnormal_response_to1.09509677
65MP0001485_abnormal_pinna_reflex1.09331841
66MP0006036_abnormal_mitochondrial_physio1.07744906
67MP0003786_premature_aging1.03792703
68MP0003011_delayed_dark_adaptation1.03507554
69MP0000716_abnormal_immune_system1.02779542
70MP0003283_abnormal_digestive_organ1.01325065
71MP0002398_abnormal_bone_marrow0.99992035
72MP0001764_abnormal_homeostasis0.98240060
73MP0001970_abnormal_pain_threshold0.94614220
74MP0010155_abnormal_intestine_physiology0.94336178
75MP0003880_abnormal_central_pattern0.93073439
76MP0002735_abnormal_chemical_nociception0.91748075
77MP0003252_abnormal_bile_duct0.91669163
78MP0001765_abnormal_ion_homeostasis0.91620851
79MP0001188_hyperpigmentation0.89186709
80MP0009745_abnormal_behavioral_response0.88901546
81MP0000689_abnormal_spleen_morphology0.87710328
82MP0001529_abnormal_vocalization0.85672410
83MP0008789_abnormal_olfactory_epithelium0.85195134
84MP0002733_abnormal_thermal_nociception0.84947286
85MP0000703_abnormal_thymus_morphology0.83205091
86MP0004134_abnormal_chest_morphology0.80867342
87MP0004742_abnormal_vestibular_system0.80019283
88MP0000681_abnormal_thyroid_gland0.79652796
89MP0005636_abnormal_mineral_homeostasis0.79259368
90MP0005410_abnormal_fertilization0.75859778
91MP0002429_abnormal_blood_cell0.75505756
92MP0001845_abnormal_inflammatory_respons0.74266228
93MP0001963_abnormal_hearing_physiology0.73969897
94MP0001501_abnormal_sleep_pattern0.72630019
95MP0002722_abnormal_immune_system0.72247846
96MP0008469_abnormal_protein_level0.72009614
97MP0005379_endocrine/exocrine_gland_phen0.71790099
98MP0005195_abnormal_posterior_eye0.71055338
99MP0001486_abnormal_startle_reflex0.69441527
100MP0009765_abnormal_xenobiotic_induced0.66732418

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.47282198
2Acute necrotizing encephalopathy (HP:0006965)4.41663259
3Mitochondrial inheritance (HP:0001427)4.26333107
4Abnormal mitochondria in muscle tissue (HP:0008316)3.87514864
5Progressive macrocephaly (HP:0004481)3.77133457
6Increased CSF lactate (HP:0002490)3.72469264
7Acute encephalopathy (HP:0006846)3.54988768
8Hepatocellular necrosis (HP:0001404)3.45776898
9Congenital stationary night blindness (HP:0007642)3.41314979
103-Methylglutaconic aciduria (HP:0003535)3.33215329
11Pancreatic cysts (HP:0001737)3.33212287
12Increased hepatocellular lipid droplets (HP:0006565)3.31777221
13Hepatic necrosis (HP:0002605)3.25986877
14Abolished electroretinogram (ERG) (HP:0000550)3.23188102
15Elevated erythrocyte sedimentation rate (HP:0003565)3.20743776
16Abnormal rod and cone electroretinograms (HP:0008323)3.19721833
17Molar tooth sign on MRI (HP:0002419)3.17963103
18Abnormality of midbrain morphology (HP:0002418)3.17963103
19IgG deficiency (HP:0004315)3.14311307
20Abnormality of cells of the erythroid lineage (HP:0012130)3.10113248
21Hypoproteinemia (HP:0003075)3.08875500
22True hermaphroditism (HP:0010459)3.06495840
23Cerebral edema (HP:0002181)2.99271067
24Lipid accumulation in hepatocytes (HP:0006561)2.98843582
25Reticulocytopenia (HP:0001896)2.91333272
26Severe combined immunodeficiency (HP:0004430)2.88394238
27Abnormality of the phalanges of the 2nd finger (HP:0009541)2.87594332
28Aplastic anemia (HP:0001915)2.85970110
29Pancreatic fibrosis (HP:0100732)2.84673387
30Abnormal number of erythroid precursors (HP:0012131)2.82760247
31Renal Fanconi syndrome (HP:0001994)2.82092499
32Optic disc pallor (HP:0000543)2.73850431
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.73190681
34Absent/shortened dynein arms (HP:0200106)2.73190681
35Thyroiditis (HP:0100646)2.71293213
36Abnormality of B cell number (HP:0010975)2.65979329
37B lymphocytopenia (HP:0010976)2.63125678
38Attenuation of retinal blood vessels (HP:0007843)2.61531861
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59883410
40Decreased central vision (HP:0007663)2.58119773
41Abnormality of the prostate (HP:0008775)2.56281555
42Stenosis of the external auditory canal (HP:0000402)2.52588319
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.51981475
44Increased serum lactate (HP:0002151)2.50724486
45Increased intramyocellular lipid droplets (HP:0012240)2.49876809
46Constricted visual fields (HP:0001133)2.48337226
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40891535
48Pendular nystagmus (HP:0012043)2.37104972
49Panhypogammaglobulinemia (HP:0003139)2.35059124
50Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.34036231
51Nephronophthisis (HP:0000090)2.33447953
52Exertional dyspnea (HP:0002875)2.32365297
53Macrocytic anemia (HP:0001972)2.32179397
54Lactic acidosis (HP:0003128)2.28052606
55Stomatitis (HP:0010280)2.25565065
56Generalized aminoaciduria (HP:0002909)2.23842502
57T lymphocytopenia (HP:0005403)2.23842050
58Abnormality of the phalanges of the 5th finger (HP:0004213)2.22283099
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19718780
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19718780
61Congenital, generalized hypertrichosis (HP:0004540)2.14304918
62Symphalangism affecting the phalanges of the hand (HP:0009773)2.10569135
63Abnormality of T cell number (HP:0011839)2.08757466
64Pallor (HP:0000980)2.08140474
65Respiratory failure (HP:0002878)2.06240915
66Aplasia/Hypoplasia of the spleen (HP:0010451)2.06128421
67Type 2 muscle fiber atrophy (HP:0003554)2.05332918
68Aplasia/hypoplasia of the uterus (HP:0008684)2.02918003
69Increased muscle lipid content (HP:0009058)2.01250701
70Abnormal respiratory epithelium morphology (HP:0012253)1.99931426
71Abnormal respiratory motile cilium morphology (HP:0005938)1.99931426
72Asplenia (HP:0001746)1.99740706
73Combined immunodeficiency (HP:0005387)1.98636264
74Palpebral edema (HP:0100540)1.98258796
75Abnormality of urine glucose concentration (HP:0011016)1.94768217
76Glycosuria (HP:0003076)1.94768217
77Cystic liver disease (HP:0006706)1.93783565
78Exercise intolerance (HP:0003546)1.89931844
79Lethargy (HP:0001254)1.88741479
80Abnormal ciliary motility (HP:0012262)1.87858197
81Abnormality of renal resorption (HP:0011038)1.87296636
82Hypoplasia of the uterus (HP:0000013)1.86639705
83Abnormality of the renal medulla (HP:0100957)1.86636657
84Colon cancer (HP:0003003)1.84076540
85Sclerocornea (HP:0000647)1.84041904
86Leukodystrophy (HP:0002415)1.80715446
87Abnormality of the renal cortex (HP:0011035)1.79675241
88Furrowed tongue (HP:0000221)1.78337470
89Type II lissencephaly (HP:0007260)1.76969246
90Abnormality of T cells (HP:0002843)1.76458224
91Abnormal respiratory motile cilium physiology (HP:0012261)1.76391540
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72065196
93Abnormality of alanine metabolism (HP:0010916)1.72065196
94Hyperalaninemia (HP:0003348)1.72065196
95Renal cortical cysts (HP:0000803)1.71292918
96Agammaglobulinemia (HP:0004432)1.70605552
97Absent thumb (HP:0009777)1.69558074
98Severe visual impairment (HP:0001141)1.68055648
99Muscle fiber atrophy (HP:0100295)1.67957049
100Chronic sinusitis (HP:0011109)1.67410325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.14305599
2CDK193.40405147
3BCKDK3.03616342
4ZAK2.84645124
5STK162.83836709
6TAOK32.65229350
7MAP4K22.64432152
8ADRBK22.59615963
9TLK12.52388197
10NUAK12.46178874
11KDR2.44185429
12GRK12.24153223
13TESK22.21668329
14FRK2.11134457
15VRK22.03475465
16MAP3K121.99692556
17NME21.76290799
18TIE11.76005730
19BMPR21.75877511
20TEC1.62915464
21MAP4K11.62473579
22ITK1.50204311
23LIMK11.44357675
24VRK11.36580970
25SCYL21.35950068
26KIT1.29837649
27DYRK21.27306070
28CSNK1G31.18072909
29MST41.16845666
30WNK41.16446793
31SYK1.13386272
32PINK11.11367390
33WNK31.06437384
34CSNK1G21.05026697
35DAPK11.03708215
36BMPR1B1.00273305
37IKBKB0.98916075
38CAMKK20.98828772
39GRK60.97205808
40MYLK0.96831246
41BTK0.96084298
42CSNK1A1L0.94046602
43OXSR10.92793408
44PIK3CG0.91681908
45CSF1R0.91102207
46PHKG20.89594357
47PHKG10.89594357
48INSRR0.85566349
49MAP2K70.84313157
50OBSCN0.84075988
51LCK0.83839498
52CSNK1G10.83800019
53PRKCQ0.81923528
54TNK20.81866488
55RPS6KA50.80644061
56FES0.77863439
57TNIK0.77243821
58PASK0.76964672
59LYN0.76208899
60EIF2AK30.75195730
61DAPK30.72446737
62JAK30.65358519
63TAF10.64110055
64PIK3CA0.62639647
65MAPK130.61526814
66ERBB30.61118291
67ILK0.60001650
68CDK80.58558175
69MATK0.57363914
70MUSK0.55652432
71ADRBK10.55613118
72IKBKE0.55382173
73DAPK20.54305194
74RPS6KA40.53591362
75MAP3K40.53115669
76GRK70.52863922
77FLT30.49448127
78PRKCE0.49373722
79PIM10.49017673
80CAMKK10.45248937
81AURKA0.44756312
82IGF1R0.43931611
83PRKACA0.42374818
84CSNK2A10.37263321
85CSNK2A20.36266336
86PRKCA0.35541411
87GRK50.33212009
88TRIM280.32703151
89ABL10.30538845
90PLK40.30326963
91PRKCD0.30202992
92CCNB10.29829728
93PRKCH0.28151273
94PRKCG0.28124915
95CSNK1A10.27865197
96STK390.27300852
97MAP2K60.27088790
98SRPK10.24868256
99TBK10.24665941
100TYRO30.23595107

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.54062607
2Asthma_Homo sapiens_hsa053103.97731446
3Oxidative phosphorylation_Homo sapiens_hsa001903.70621907
4Proteasome_Homo sapiens_hsa030503.32506650
5Allograft rejection_Homo sapiens_hsa053303.25480781
6Autoimmune thyroid disease_Homo sapiens_hsa053203.24567749
7Parkinsons disease_Homo sapiens_hsa050123.04103807
8Graft-versus-host disease_Homo sapiens_hsa053323.01614680
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.81052155
10Type I diabetes mellitus_Homo sapiens_hsa049402.59617414
11Primary immunodeficiency_Homo sapiens_hsa053402.59346674
12RNA polymerase_Homo sapiens_hsa030202.10649610
13Alzheimers disease_Homo sapiens_hsa050102.02721910
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98649079
15Antigen processing and presentation_Homo sapiens_hsa046121.90681036
16Huntingtons disease_Homo sapiens_hsa050161.87574640
17Cardiac muscle contraction_Homo sapiens_hsa042601.84863852
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76968787
19Protein export_Homo sapiens_hsa030601.72238297
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68976024
21Phototransduction_Homo sapiens_hsa047441.68669422
22Rheumatoid arthritis_Homo sapiens_hsa053231.66004915
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51183743
24Linoleic acid metabolism_Homo sapiens_hsa005911.43937296
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33662975
26RNA degradation_Homo sapiens_hsa030181.27863640
27Caffeine metabolism_Homo sapiens_hsa002321.27127735
28Viral myocarditis_Homo sapiens_hsa054161.22402404
29Hematopoietic cell lineage_Homo sapiens_hsa046401.18417118
30Systemic lupus erythematosus_Homo sapiens_hsa053221.07260090
31Homologous recombination_Homo sapiens_hsa034401.04393268
32Pyrimidine metabolism_Homo sapiens_hsa002401.03993517
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01240483
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98772567
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97777131
36Nitrogen metabolism_Homo sapiens_hsa009100.96534593
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87630342
38Staphylococcus aureus infection_Homo sapiens_hsa051500.87282400
39Arachidonic acid metabolism_Homo sapiens_hsa005900.83931985
40Chemical carcinogenesis_Homo sapiens_hsa052040.83507997
41Purine metabolism_Homo sapiens_hsa002300.82207351
42Peroxisome_Homo sapiens_hsa041460.81660364
43Olfactory transduction_Homo sapiens_hsa047400.80208438
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.79609374
45One carbon pool by folate_Homo sapiens_hsa006700.78955690
46Spliceosome_Homo sapiens_hsa030400.78724285
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77774000
48Tryptophan metabolism_Homo sapiens_hsa003800.76808281
49Regulation of autophagy_Homo sapiens_hsa041400.72243219
50Retinol metabolism_Homo sapiens_hsa008300.70235810
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68777989
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.67012629
53Collecting duct acid secretion_Homo sapiens_hsa049660.63874517
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63258572
55Nucleotide excision repair_Homo sapiens_hsa034200.63032562
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62649178
57T cell receptor signaling pathway_Homo sapiens_hsa046600.62453307
58Fanconi anemia pathway_Homo sapiens_hsa034600.61841926
59Butanoate metabolism_Homo sapiens_hsa006500.61437909
60Nicotine addiction_Homo sapiens_hsa050330.60967118
61Leishmaniasis_Homo sapiens_hsa051400.60728722
62Propanoate metabolism_Homo sapiens_hsa006400.60661994
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59244232
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.57390866
65Basal transcription factors_Homo sapiens_hsa030220.57245477
66Ether lipid metabolism_Homo sapiens_hsa005650.56216403
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55497971
68Morphine addiction_Homo sapiens_hsa050320.54431549
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54063426
70Taste transduction_Homo sapiens_hsa047420.53427541
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52644537
72RNA transport_Homo sapiens_hsa030130.51824429
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51211345
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49425901
75DNA replication_Homo sapiens_hsa030300.47862073
76Sulfur metabolism_Homo sapiens_hsa009200.47742395
77Mismatch repair_Homo sapiens_hsa034300.45324696
78Metabolic pathways_Homo sapiens_hsa011000.44318861
79Salivary secretion_Homo sapiens_hsa049700.42434642
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.39122597
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.38158303
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31907234
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31375797
84Serotonergic synapse_Homo sapiens_hsa047260.29125412
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.28948687
86Herpes simplex infection_Homo sapiens_hsa051680.28817430
87Circadian entrainment_Homo sapiens_hsa047130.28178614
88Epstein-Barr virus infection_Homo sapiens_hsa051690.27708418
89Base excision repair_Homo sapiens_hsa034100.27278547
90Glutathione metabolism_Homo sapiens_hsa004800.25541711
91Fat digestion and absorption_Homo sapiens_hsa049750.25272904
92GABAergic synapse_Homo sapiens_hsa047270.25257601
93Sulfur relay system_Homo sapiens_hsa041220.20581157
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19576072
95Measles_Homo sapiens_hsa051620.16179269
96Tuberculosis_Homo sapiens_hsa051520.15977684
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14698946
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12990923
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12917956
100Selenocompound metabolism_Homo sapiens_hsa004500.12598078

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