ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	8.74178089
2	viral transcription (GO:0019083)	7.38409907
3	translational termination (GO:0006415)	7.09187354
4	ribosomal small subunit biogenesis (GO:0042274)	6.79067115
5	GDP-mannose metabolic process (GO:0019673)	6.57650115
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.45820056
7	ATP synthesis coupled proton transport (GO:0015986)	6.45820056
8	ribosomal small subunit assembly (GO:0000028)	6.26765551
9	translational elongation (GO:0006414)	6.25149533
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.02013596
11	cotranslational protein targeting to membrane (GO:0006613)	5.90040622
12	mannose metabolic process (GO:0006013)	5.89485154
13	protein targeting to ER (GO:0045047)	5.85758543
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.60584765
15	protein localization to endoplasmic reticulum (GO:0070972)	5.51056857
16	DNA deamination (GO:0045006)	5.35605406
17	nucleoside transmembrane transport (GO:1901642)	5.35044921
18	cellular protein complex disassembly (GO:0043624)	5.34988079
19	viral life cycle (GO:0019058)	5.32664042
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.20735087
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.87823353
22	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.84154513
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.60994137
24	maturation of SSU-rRNA (GO:0030490)	4.55477607
25	translational initiation (GO:0006413)	4.53000404
26	protein complex disassembly (GO:0043241)	4.43332473
27	ribosomal large subunit biogenesis (GO:0042273)	4.30495394
28	water-soluble vitamin biosynthetic process (GO:0042364)	4.23954909
29	macromolecular complex disassembly (GO:0032984)	4.20707869
30	protein neddylation (GO:0045116)	4.19778787
31	protein targeting to membrane (GO:0006612)	4.08772941
32	translation (GO:0006412)	4.07261832
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.01961115
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.01961115
35	nucleoside transport (GO:0015858)	4.00696084
36	behavioral response to nicotine (GO:0035095)	3.99481869
37	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.98090954
38	mRNA catabolic process (GO:0006402)	3.76493195
39	respiratory electron transport chain (GO:0022904)	3.67111076
40	electron transport chain (GO:0022900)	3.66665721
41	positive regulation of fatty acid transport (GO:2000193)	3.61576257
42	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.60876083
43	ATP biosynthetic process (GO:0006754)	3.55039363
44	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.53654576
45	interferon-gamma production (GO:0032609)	3.53025376
46	GTP biosynthetic process (GO:0006183)	3.49269418
47	positive regulation of icosanoid secretion (GO:0032305)	3.46232587
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.45482636
49	cellular component biogenesis (GO:0044085)	3.41856788
50	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.41798407
51	RNA catabolic process (GO:0006401)	3.35894473
52	ribonucleoprotein complex biogenesis (GO:0022613)	3.30976530
53	coenzyme A biosynthetic process (GO:0015937)	3.30321151
54	hydrogen ion transmembrane transport (GO:1902600)	3.28803094
55	lateral ventricle development (GO:0021670)	3.28193054
56	negative regulation of cAMP-mediated signaling (GO:0043951)	3.21051365
57	peroxisome fission (GO:0016559)	3.18534656
58	reproduction (GO:0000003)	3.18478292
59	pantothenate metabolic process (GO:0015939)	3.14219178
60	cytidine metabolic process (GO:0046087)	3.07561706
61	cytidine catabolic process (GO:0006216)	3.07561706
62	cytidine deamination (GO:0009972)	3.07561706
63	spliceosomal complex assembly (GO:0000245)	3.03150474
64	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.02787897
65	proton transport (GO:0015992)	2.99196454
66	short-chain fatty acid metabolic process (GO:0046459)	2.98532200
67	intracellular protein transmembrane import (GO:0044743)	2.97289445
68	cofactor transport (GO:0051181)	2.97163523
69	modified amino acid transport (GO:0072337)	2.96513882
70	hydrogen transport (GO:0006818)	2.93758995
71	positive regulation of respiratory burst (GO:0060267)	2.93235752
72	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.92017559
73	meiotic chromosome segregation (GO:0045132)	2.91177892
74	UTP biosynthetic process (GO:0006228)	2.89753853
75	protein complex biogenesis (GO:0070271)	2.85766476
76	cell proliferation in forebrain (GO:0021846)	2.80835146
77	response to pheromone (GO:0019236)	2.80736405
78	nonmotile primary cilium assembly (GO:0035058)	2.78880225
79	establishment of protein localization to membrane (GO:0090150)	2.78714246
80	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78473903
81	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78473903
82	NADH dehydrogenase complex assembly (GO:0010257)	2.78473903
83	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.74482862
84	sulfur compound transport (GO:0072348)	2.74331625
85	antibacterial humoral response (GO:0019731)	2.69058053
86	regulation of female receptivity (GO:0045924)	2.69026045
87	aerobic respiration (GO:0009060)	2.68791505
88	negative regulation of appetite (GO:0032099)	2.64970790
89	negative regulation of response to food (GO:0032096)	2.64970790
90	negative regulation of heart rate (GO:0010459)	2.63819828
91	piRNA metabolic process (GO:0034587)	2.62843145
92	UTP metabolic process (GO:0046051)	2.62032096
93	indolalkylamine metabolic process (GO:0006586)	2.61447893
94	mannosylation (GO:0097502)	2.59662837
95	regulation of mitochondrial membrane potential (GO:0051881)	2.59407346
96	regulation of cilium movement (GO:0003352)	2.58206444
97	mitochondrial respiratory chain complex assembly (GO:0033108)	2.58161237
98	rRNA processing (GO:0006364)	2.57340171
99	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.56901653
100	cellular response to estradiol stimulus (GO:0071392)	2.56843816

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.78095554
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.69219788
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.56144796
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.27624228
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.14386423
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.07339124
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86284499
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.85516848
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.83253416
10	VDR_22108803_ChIP-Seq_LS180_Human	2.62375557
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.49681721
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.46629329
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40461460
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.01620073
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.76596587
16	VDR_23849224_ChIP-Seq_CD4+_Human	1.76291439
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.74460069
18	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.72321575
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.69055628
20	FUS_26573619_Chip-Seq_HEK293_Human	1.68582631
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.68014927
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67002138
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63277097
24	NANOG_20526341_ChIP-Seq_ESCs_Human	1.63023282
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.62508008
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.58255692
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.55176632
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54015329
29	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.49415306
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43915609
31	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.42200735
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.37639631
33	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.35352781
34	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.33786634
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32392740
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31438578
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31438578
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29863767
39	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.29805575
40	EWS_26573619_Chip-Seq_HEK293_Human	1.26773327
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25116985
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23693578
43	TTF2_22483619_ChIP-Seq_HELA_Human	1.22680424
44	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21718425
45	MYC_19829295_ChIP-Seq_ESCs_Human	1.20171086
46	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.19642689
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.19515266
48	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.18653146
49	NCOR_22424771_ChIP-Seq_293T_Human	1.17865864
50	E2F1_20622854_ChIP-Seq_HELA_Human	1.16878950
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14663824
52	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.13868723
53	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12328723
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10923818
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10738093
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10652146
57	AR_20517297_ChIP-Seq_VCAP_Human	1.10169007
58	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09730507
59	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.09484216
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08876452
61	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08788666
62	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.08460120
63	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.07725366
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.07547777
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.07065956
66	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.06206909
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.05537448
68	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.05313498
69	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.03991473
70	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.03851013
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.03007490
72	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.02848015
73	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02380078
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02203897
75	RBPJ_21746931_ChIP-Seq_IB4_Human	1.02123895
76	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.01339726
77	ERA_21632823_ChIP-Seq_H3396_Human	1.01309068
78	PHF8_20622853_ChIP-Seq_HELA_Human	1.01013119
79	SOX2_21211035_ChIP-Seq_LN229_Human	1.00429613
80	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00134376
81	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00134376
82	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.99697660
83	P300_19829295_ChIP-Seq_ESCs_Human	0.99625713
84	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.98656353
85	ETV1_20927104_ChIP-Seq_GIST48_Human	0.98588158
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98104822
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97469557
88	XRN2_22483619_ChIP-Seq_HELA_Human	0.94529457
89	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.94148073
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.93882113
91	RAC3_21632823_ChIP-Seq_H3396_Human	0.92856366
92	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.92851728
93	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.87936710
94	REST_21632747_ChIP-Seq_MESCs_Mouse	0.85526499
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.85167565
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.84724657
97	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84400816
98	DCP1A_22483619_ChIP-Seq_HELA_Human	0.84215134
99	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.83999281
100	STAT1_20625510_ChIP-Seq_HELA_Human	0.83575164

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.98232887
2	MP0006072_abnormal_retinal_apoptosis	3.49769384
3	MP0006292_abnormal_olfactory_placode	3.40253827
4	MP0002638_abnormal_pupillary_reflex	3.40225885
5	MP0003646_muscle_fatigue	2.57451177
6	MP0002163_abnormal_gland_morphology	2.54095448
7	MP0001968_abnormal_touch/_nociception	2.24078297
8	MP0001529_abnormal_vocalization	2.14500888
9	MP0005671_abnormal_response_to	2.07458275
10	MP0003880_abnormal_central_pattern	1.86779181
11	MP0001986_abnormal_taste_sensitivity	1.83716276
12	MP0002160_abnormal_reproductive_system	1.80950162
13	MP0004885_abnormal_endolymph	1.80366828
14	MP0008877_abnormal_DNA_methylation	1.78015532
15	MP0004142_abnormal_muscle_tone	1.72055279
16	MP0003136_yellow_coat_color	1.68622187
17	MP0008872_abnormal_physiological_respon	1.68176633
18	MP0001485_abnormal_pinna_reflex	1.62238262
19	MP0004043_abnormal_pH_regulation	1.61438705
20	MP0008789_abnormal_olfactory_epithelium	1.58275555
21	MP0003787_abnormal_imprinting	1.57211627
22	MP0005645_abnormal_hypothalamus_physiol	1.55685569
23	MP0006276_abnormal_autonomic_nervous	1.54899361
24	MP0001501_abnormal_sleep_pattern	1.52867288
25	MP0005389_reproductive_system_phenotype	1.51682771
26	MP0002876_abnormal_thyroid_physiology	1.50421998
27	MP0004145_abnormal_muscle_electrophysio	1.49622003
28	MP0003195_calcinosis	1.49317817
29	MP0005379_endocrine/exocrine_gland_phen	1.49007331
30	MP0005360_urolithiasis	1.46574195
31	MP0001727_abnormal_embryo_implantation	1.43504805
32	MP0000372_irregular_coat_pigmentation	1.43011020
33	MP0008875_abnormal_xenobiotic_pharmacok	1.40243070
34	MP0002736_abnormal_nociception_after	1.38907722
35	MP0001905_abnormal_dopamine_level	1.37790732
36	MP0002234_abnormal_pharynx_morphology	1.37749517
37	MP0001835_abnormal_antigen_presentation	1.37111903
38	MP0001873_stomach_inflammation	1.34919310
39	MP0005551_abnormal_eye_electrophysiolog	1.32895329
40	MP0002148_abnormal_hypersensitivity_rea	1.32019251
41	MP0000049_abnormal_middle_ear	1.31234630
42	MP0004133_heterotaxia	1.31216583
43	MP0005253_abnormal_eye_physiology	1.29502595
44	MP0009764_decreased_sensitivity_to	1.28684686
45	MP0002272_abnormal_nervous_system	1.26946744
46	MP0002277_abnormal_respiratory_mucosa	1.25935566
47	MP0001970_abnormal_pain_threshold	1.18177026
48	MP0003806_abnormal_nucleotide_metabolis	1.16133476
49	MP0002733_abnormal_thermal_nociception	1.15172254
50	MP0001984_abnormal_olfaction	1.13136333
51	MP0005394_taste/olfaction_phenotype	1.12943333
52	MP0005499_abnormal_olfactory_system	1.12943333
53	MP0005195_abnormal_posterior_eye	1.12026513
54	MP0005085_abnormal_gallbladder_physiolo	1.10282782
55	MP0005174_abnormal_tail_pigmentation	1.09062686
56	MP0002837_dystrophic_cardiac_calcinosis	1.08717717
57	MP0001919_abnormal_reproductive_system	1.08266128
58	MP0000678_abnormal_parathyroid_gland	1.07901276
59	MP0003011_delayed_dark_adaptation	1.06199156
60	MP0009745_abnormal_behavioral_response	1.05472738
61	MP0001293_anophthalmia	1.02231602
62	MP0002572_abnormal_emotion/affect_behav	1.01884175
63	MP0002938_white_spotting	1.01730743
64	MP0008775_abnormal_heart_ventricle	1.01565069
65	MP0001440_abnormal_grooming_behavior	0.97340834
66	MP0004742_abnormal_vestibular_system	0.96604879
67	MP0002653_abnormal_ependyma_morphology	0.96372384
68	MP0009333_abnormal_splenocyte_physiolog	0.96072596
69	MP0002734_abnormal_mechanical_nocicepti	0.92742839
70	MP0005332_abnormal_amino_acid	0.91800371
71	MP0003718_maternal_effect	0.91512908
72	MP0001664_abnormal_digestion	0.90963090
73	MP0004019_abnormal_vitamin_homeostasis	0.90550638
74	MP0009780_abnormal_chondrocyte_physiolo	0.88790025
75	MP0001790_abnormal_immune_system	0.87571747
76	MP0005387_immune_system_phenotype	0.87571747
77	MP0005503_abnormal_tendon_morphology	0.87241803
78	MP0002557_abnormal_social/conspecific_i	0.86502590
79	MP0009250_abnormal_appendicular_skeleto	0.86096049
80	MP0000631_abnormal_neuroendocrine_gland	0.85501863
81	MP0002210_abnormal_sex_determination	0.85193454
82	MP0005084_abnormal_gallbladder_morpholo	0.82040687
83	MP0002095_abnormal_skin_pigmentation	0.80877988
84	MP0003879_abnormal_hair_cell	0.80471423
85	MP0005075_abnormal_melanosome_morpholog	0.80354000
86	MP0005646_abnormal_pituitary_gland	0.80005073
87	MP0002735_abnormal_chemical_nociception	0.79446509
88	MP0001765_abnormal_ion_homeostasis	0.78170589
89	MP0003183_abnormal_peptide_metabolism	0.77269578
90	MP0006036_abnormal_mitochondrial_physio	0.76571446
91	MP0003878_abnormal_ear_physiology	0.75866261
92	MP0005377_hearing/vestibular/ear_phenot	0.75866261
93	MP0002249_abnormal_larynx_morphology	0.73085241
94	MP0001663_abnormal_digestive_system	0.71998437
95	MP0000427_abnormal_hair_cycle	0.71387048
96	MP0002752_abnormal_somatic_nervous	0.71170322
97	MP0005636_abnormal_mineral_homeostasis	0.70806188
98	MP0003567_abnormal_fetal_cardiomyocyte	0.67054586
99	MP0003638_abnormal_response/metabolism_	0.67034025
100	MP0004924_abnormal_behavior	0.66351097

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Global brain atrophy (HP:0002283)	4.81478087
2	Hyperglycinemia (HP:0002154)	4.28216744
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.07172216
4	3-Methylglutaconic aciduria (HP:0003535)	3.85289035
5	Methylmalonic acidemia (HP:0002912)	3.83728161
6	Reticulocytopenia (HP:0001896)	3.57688371
7	Macrocytic anemia (HP:0001972)	3.52473993
8	Hypobetalipoproteinemia (HP:0003563)	3.47819748
9	Stenosis of the external auditory canal (HP:0000402)	3.33198139
10	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.25182843
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.24516825
12	Methylmalonic aciduria (HP:0012120)	3.23849013
13	Type II lissencephaly (HP:0007260)	3.22185225
14	Mitochondrial inheritance (HP:0001427)	3.21177278
15	Abnormality of midbrain morphology (HP:0002418)	3.14808460
16	Molar tooth sign on MRI (HP:0002419)	3.14808460
17	Acute necrotizing encephalopathy (HP:0006965)	3.08409977
18	Increased CSF lactate (HP:0002490)	3.01973548
19	Abnormality of alanine metabolism (HP:0010916)	2.97672624
20	Hyperalaninemia (HP:0003348)	2.97672624
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.97672624
22	Hepatocellular necrosis (HP:0001404)	2.97370669
23	Akinesia (HP:0002304)	2.97152192
24	Patent foramen ovale (HP:0001655)	2.96142966
25	Dyskinesia (HP:0100660)	2.83649516
26	Acanthocytosis (HP:0001927)	2.81415624
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.78424914
28	Increased hepatocellular lipid droplets (HP:0006565)	2.74311221
29	Agitation (HP:0000713)	2.74119209
30	Abnormal number of erythroid precursors (HP:0012131)	2.73227251
31	Congenital stationary night blindness (HP:0007642)	2.73120457
32	Microretrognathia (HP:0000308)	2.69292355
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.67662869
34	Hepatic necrosis (HP:0002605)	2.64524946
35	Elevated erythrocyte sedimentation rate (HP:0003565)	2.64384404
36	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.62801043
37	Pallor (HP:0000980)	2.61944909
38	Progressive macrocephaly (HP:0004481)	2.60656093
39	Delayed CNS myelination (HP:0002188)	2.60275002
40	Neurodegeneration (HP:0002180)	2.59602909
41	Acute encephalopathy (HP:0006846)	2.56654849
42	Pancreatic cysts (HP:0001737)	2.56346344
43	Renal Fanconi syndrome (HP:0001994)	2.55602995
44	Abnormality of vitamin B metabolism (HP:0004340)	2.49322789
45	Thyroid-stimulating hormone excess (HP:0002925)	2.49289710
46	Lipid accumulation in hepatocytes (HP:0006561)	2.48435885
47	Abnormality of serum amino acid levels (HP:0003112)	2.43858794
48	Congenital, generalized hypertrichosis (HP:0004540)	2.43669031
49	Abnormality of glycine metabolism (HP:0010895)	2.40702725
50	Abnormality of serine family amino acid metabolism (HP:0010894)	2.40702725
51	Cerebellar dysplasia (HP:0007033)	2.39848385
52	Decreased muscle mass (HP:0003199)	2.39530011
53	Partial duplication of the phalanx of hand (HP:0009999)	2.37845745
54	Abolished electroretinogram (ERG) (HP:0000550)	2.36715738
55	Large eyes (HP:0001090)	2.36077211
56	Aplasia/hypoplasia of the uterus (HP:0008684)	2.33835193
57	Dysphonia (HP:0001618)	2.32311159
58	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.28914967
59	Tubulointerstitial nephritis (HP:0001970)	2.28828697
60	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.27640221
61	Medial flaring of the eyebrow (HP:0010747)	2.22179917
62	Nephronophthisis (HP:0000090)	2.18804303
63	Pancreatic fibrosis (HP:0100732)	2.17930574
64	Hypoplasia of the uterus (HP:0000013)	2.16801027
65	Increased serum lactate (HP:0002151)	2.16646916
66	Brushfield spots (HP:0001088)	2.13003075
67	Abnormality of the 2nd finger (HP:0004100)	2.10904328
68	Optic disc pallor (HP:0000543)	2.10237460
69	Respiratory difficulties (HP:0002880)	2.08163874
70	Restlessness (HP:0000711)	2.07024860
71	Ketosis (HP:0001946)	2.05617485
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.05177897
73	Hypoplasia of the radius (HP:0002984)	2.03873807
74	CNS demyelination (HP:0007305)	1.98745992
75	Increased intramyocellular lipid droplets (HP:0012240)	1.97862300
76	Glycosuria (HP:0003076)	1.96847210
77	Abnormality of urine glucose concentration (HP:0011016)	1.96847210
78	True hermaphroditism (HP:0010459)	1.96717261
79	Absent thumb (HP:0009777)	1.94537545
80	Septo-optic dysplasia (HP:0100842)	1.94204402
81	Exertional dyspnea (HP:0002875)	1.90571974
82	Lactic acidosis (HP:0003128)	1.90515060
83	Clumsiness (HP:0002312)	1.88881377
84	Abnormality of magnesium homeostasis (HP:0004921)	1.87535861
85	Impulsivity (HP:0100710)	1.87395992
86	Diminished movement (HP:0002374)	1.87031837
87	Abnormality of the renal medulla (HP:0100957)	1.85759857
88	Hypomagnesemia (HP:0002917)	1.85341769
89	Abnormal drinking behavior (HP:0030082)	1.85187788
90	Polydipsia (HP:0001959)	1.85187788
91	Broad distal phalanx of finger (HP:0009836)	1.84862866
92	Metabolic alkalosis (HP:0200114)	1.83743968
93	Abnormality of renal resorption (HP:0011038)	1.81673935
94	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.80825125
95	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.80699956
96	Dicarboxylic aciduria (HP:0003215)	1.80699956
97	Cerebral edema (HP:0002181)	1.78871713
98	Abnormality of the labia minora (HP:0012880)	1.78611949
99	Tubular atrophy (HP:0000092)	1.78206874
100	Buphthalmos (HP:0000557)	1.77066023

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ADRBK2	3.43342777
2	TLK1	3.23710509
3	MAP4K2	3.12743922
4	ZAK	3.03366513
5	CDK19	2.88294579
6	FRK	2.85807259
7	NUAK1	2.64284156
8	WNK4	2.50356601
9	WNK3	2.48905259
10	PDK2	2.42053216
11	ERN1	2.38134308
12	NME2	2.08037245
13	GRK1	2.07999708
14	PINK1	1.97092511
15	TAOK3	1.86433270
16	MAP2K6	1.81940285
17	TXK	1.75800485
18	BCKDK	1.71398679
19	PASK	1.71349423
20	DYRK2	1.68105326
21	OXSR1	1.61266311
22	EPHA4	1.53212967
23	PLK4	1.50775519
24	MAP3K12	1.39076542
25	BMPR1B	1.37706526
26	VRK1	1.24948377
27	VRK2	1.19559661
28	ADRBK1	1.14805757
29	LRRK2	1.13860085
30	STK39	1.05510408
31	NEK2	1.04147769
32	TGFBR1	0.98219354
33	AKT2	0.98181798
34	BUB1	0.96026546
35	PRKCG	0.92921426
36	RPS6KA5	0.88041096
37	CSF1R	0.85573423
38	STK16	0.84715988
39	TIE1	0.84411000
40	CAMKK2	0.83167347
41	MAP4K1	0.81031198
42	INSRR	0.80207123
43	KIT	0.80030058
44	MAP3K4	0.79979975
45	LCK	0.78520234
46	TEC	0.77014368
47	SYK	0.76972358
48	PKN1	0.76744296
49	DAPK3	0.70953678
50	ACVR1B	0.70613058
51	OBSCN	0.70139822
52	MAP2K4	0.67302732
53	MAP2K2	0.66806542
54	CDK8	0.66656902
55	IKBKB	0.65721829
56	MYLK	0.65060360
57	MAPKAPK5	0.64977134
58	CSNK2A2	0.64582075
59	PRKACA	0.64247069
60	PIM1	0.64227996
61	PRKCE	0.63070607
62	MAP2K7	0.60580229
63	CSNK2A1	0.57962108
64	SRPK1	0.57247202
65	KDR	0.56664629
66	BMPR2	0.56226016
67	PRKCQ	0.55585217
68	ITK	0.55302803
69	PRKCD	0.54945047
70	PHKG2	0.53781850
71	PHKG1	0.53781850
72	IRAK4	0.53008217
73	PRKCA	0.52952388
74	CAMK1	0.52894891
75	MARK3	0.52876512
76	FLT3	0.52286265
77	MAPK13	0.50893115
78	CAMK2A	0.50823486
79	PIK3CG	0.50769936
80	MKNK1	0.50595880
81	GRK6	0.49121707
82	AURKA	0.46959675
83	ABL2	0.46759936
84	MATK	0.46431245
85	FES	0.44542023
86	MAP3K6	0.43625942
87	BRAF	0.43084520
88	CASK	0.42927746
89	PRKG2	0.42309015
90	ATR	0.41586591
91	CAMKK1	0.41268873
92	PRKCZ	0.40503781
93	AURKB	0.39876138
94	ILK	0.38692156
95	LYN	0.38474512
96	TRIM28	0.37958717
97	BTK	0.37259424
98	EPHB2	0.36998795
99	TYRO3	0.35583823
100	SIK2	0.35425256

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.89605581
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.64427762
3	Asthma_Homo sapiens_hsa05310	3.26731046
4	Parkinsons disease_Homo sapiens_hsa05012	3.09780315
5	Allograft rejection_Homo sapiens_hsa05330	2.41226619
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.36936084
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.25588894
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.22943728
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.21597313
10	Sulfur metabolism_Homo sapiens_hsa00920	2.21237466
11	Alzheimers disease_Homo sapiens_hsa05010	2.09518975
12	RNA polymerase_Homo sapiens_hsa03020	2.07507584
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.06465882
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.99564454
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96644314
16	Huntingtons disease_Homo sapiens_hsa05016	1.92193688
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.88627963
18	Proteasome_Homo sapiens_hsa03050	1.76213782
19	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.72466528
20	RNA degradation_Homo sapiens_hsa03018	1.67984329
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53467192
22	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.41231396
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38915114
24	Protein export_Homo sapiens_hsa03060	1.32162291
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.32065781
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.28975645
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19743129
28	Phototransduction_Homo sapiens_hsa04744	1.18498338
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.17825900
30	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.17137012
31	One carbon pool by folate_Homo sapiens_hsa00670	1.17030327
32	Regulation of autophagy_Homo sapiens_hsa04140	1.16788131
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.16438504
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12381995
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.11117393
36	Fat digestion and absorption_Homo sapiens_hsa04975	1.06777327
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06241892
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01415762
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.00354776
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99296434
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94991920
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.94068488
43	Propanoate metabolism_Homo sapiens_hsa00640	0.91416645
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.90482468
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.89980480
46	Nicotine addiction_Homo sapiens_hsa05033	0.89380587
47	Sulfur relay system_Homo sapiens_hsa04122	0.88694130
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.87426812
49	Homologous recombination_Homo sapiens_hsa03440	0.87068822
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.85415573
51	Peroxisome_Homo sapiens_hsa04146	0.85199806
52	Rheumatoid arthritis_Homo sapiens_hsa05323	0.80940829
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80715317
54	Retinol metabolism_Homo sapiens_hsa00830	0.78096782
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.77656888
56	Butanoate metabolism_Homo sapiens_hsa00650	0.77655344
57	Caffeine metabolism_Homo sapiens_hsa00232	0.75054997
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74962052
59	Olfactory transduction_Homo sapiens_hsa04740	0.74840777
60	Antigen processing and presentation_Homo sapiens_hsa04612	0.73761414
61	Primary immunodeficiency_Homo sapiens_hsa05340	0.72884906
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70439047
63	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.68522066
64	Metabolic pathways_Homo sapiens_hsa01100	0.67064728
65	Basal transcription factors_Homo sapiens_hsa03022	0.65141328
66	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.65122367
67	Purine metabolism_Homo sapiens_hsa00230	0.64264901
68	Glutathione metabolism_Homo sapiens_hsa00480	0.58967454
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.58348335
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.54743318
71	Salivary secretion_Homo sapiens_hsa04970	0.54564725
72	Morphine addiction_Homo sapiens_hsa05032	0.54124388
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53234112
74	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.52559379
75	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.51971961
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49599020
77	Mismatch repair_Homo sapiens_hsa03430	0.48608886
78	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.46522985
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46038782
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45715804
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43198757
82	Taste transduction_Homo sapiens_hsa04742	0.41295021
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38871977
84	Viral myocarditis_Homo sapiens_hsa05416	0.37896256
85	Serotonergic synapse_Homo sapiens_hsa04726	0.36433992
86	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33625423
87	Fatty acid degradation_Homo sapiens_hsa00071	0.33372818
88	Renin-angiotensin system_Homo sapiens_hsa04614	0.33060436
89	GABAergic synapse_Homo sapiens_hsa04727	0.32878042
90	Leishmaniasis_Homo sapiens_hsa05140	0.32614405
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32524723
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32328494
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31463563
94	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30069872
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29313265
96	Spliceosome_Homo sapiens_hsa03040	0.28237443
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27053971
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26567200
99	Circadian entrainment_Homo sapiens_hsa04713	0.25719707
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.25631478

RPS4XP8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »