ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	6.59286908
2	ATP synthesis coupled proton transport (GO:0015986)	6.56490923
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.56490923
4	DNA deamination (GO:0045006)	6.24870155
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.00455608
6	ribosomal small subunit assembly (GO:0000028)	5.91740781
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.87859970
8	chaperone-mediated protein transport (GO:0072321)	5.87475875
9	maturation of SSU-rRNA (GO:0030490)	5.55947494
10	viral transcription (GO:0019083)	5.52472763
11	translational termination (GO:0006415)	5.30142892
12	respiratory electron transport chain (GO:0022904)	5.16707675
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.11627595
14	NADH dehydrogenase complex assembly (GO:0010257)	5.11627595
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.11627595
16	electron transport chain (GO:0022900)	5.09592583
17	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.07788774
18	rRNA modification (GO:0000154)	4.83140054
19	translational elongation (GO:0006414)	4.81837910
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.73625581
21	protein complex biogenesis (GO:0070271)	4.70243495
22	pseudouridine synthesis (GO:0001522)	4.65575000
23	cotranslational protein targeting to membrane (GO:0006613)	4.62064636
24	protein targeting to ER (GO:0045047)	4.60345125
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.60232119
26	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.52759961
27	mitochondrial respiratory chain complex assembly (GO:0033108)	4.52596512
28	proteasome assembly (GO:0043248)	4.45329151
29	protein localization to endoplasmic reticulum (GO:0070972)	4.40377040
30	peptidyl-histidine modification (GO:0018202)	4.40297171
31	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.37353740
32	protein targeting to mitochondrion (GO:0006626)	4.18276713
33	GTP biosynthetic process (GO:0006183)	4.17444175
34	translation (GO:0006412)	4.09026686
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.08306180
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.07631640
37	ribosomal large subunit biogenesis (GO:0042273)	4.04859178
38	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.04121609
39	cellular component biogenesis (GO:0044085)	4.03596052
40	ribonucleoprotein complex biogenesis (GO:0022613)	4.00660519
41	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.99653163
42	viral life cycle (GO:0019058)	3.97487205
43	cellular protein complex disassembly (GO:0043624)	3.96065001
44	ATP biosynthetic process (GO:0006754)	3.94034948
45	translational initiation (GO:0006413)	3.91336021
46	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.83848097
47	establishment of protein localization to mitochondrion (GO:0072655)	3.81179594
48	pyrimidine nucleotide catabolic process (GO:0006244)	3.80326756
49	rRNA processing (GO:0006364)	3.79783149
50	termination of RNA polymerase III transcription (GO:0006386)	3.79755805
51	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.79755805
52	rRNA metabolic process (GO:0016072)	3.70938087
53	protein-cofactor linkage (GO:0018065)	3.69049609
54	UTP metabolic process (GO:0046051)	3.68913164
55	UTP biosynthetic process (GO:0006228)	3.66285133
56	rRNA methylation (GO:0031167)	3.66141314
57	protein neddylation (GO:0045116)	3.61469262
58	protein localization to mitochondrion (GO:0070585)	3.60818797
59	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.55925791
60	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47730327
61	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47730327
62	inner mitochondrial membrane organization (GO:0007007)	3.39167164
63	oxidative phosphorylation (GO:0006119)	3.34101780
64	base-excision repair, AP site formation (GO:0006285)	3.32825633
65	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.32199772
66	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.28338841
67	respiratory chain complex IV assembly (GO:0008535)	3.25718346
68	regulation of mitochondrial translation (GO:0070129)	3.24456432
69	protein complex disassembly (GO:0043241)	3.24187502
70	maturation of 5.8S rRNA (GO:0000460)	3.21957360
71	water-soluble vitamin biosynthetic process (GO:0042364)	3.21226383
72	tRNA processing (GO:0008033)	3.17968164
73	hydrogen ion transmembrane transport (GO:1902600)	3.17417043
74	nucleoside triphosphate biosynthetic process (GO:0009142)	3.15574808
75	ribosome biogenesis (GO:0042254)	3.14980616
76	macromolecular complex disassembly (GO:0032984)	3.13693369
77	guanosine-containing compound biosynthetic process (GO:1901070)	3.12672342
78	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.09990134
79	mitochondrial transport (GO:0006839)	3.06441047
80	CTP biosynthetic process (GO:0006241)	3.06243509
81	CTP metabolic process (GO:0046036)	3.06243509
82	ncRNA processing (GO:0034470)	2.98596903
83	mRNA catabolic process (GO:0006402)	2.97174692
84	protein targeting to membrane (GO:0006612)	2.94194510
85	positive regulation of prostaglandin secretion (GO:0032308)	2.92684037
86	proton transport (GO:0015992)	2.90698672
87	transcription from mitochondrial promoter (GO:0006390)	2.90172614
88	purine nucleotide salvage (GO:0032261)	2.89889047
89	cytochrome complex assembly (GO:0017004)	2.86929983
90	hydrogen transport (GO:0006818)	2.86098192
91	intracellular protein transmembrane import (GO:0044743)	2.84648801
92	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.83161878
93	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.83161878
94	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.82730810
95	aldehyde catabolic process (GO:0046185)	2.82440185
96	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.82189150
97	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81502471
98	ncRNA metabolic process (GO:0034660)	2.80656532
99	deoxyribonucleotide catabolic process (GO:0009264)	2.78489732
100	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.75473127

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.73922032
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.58724245
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.43516581
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.14478726
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.83772074
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.64218304
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.62490462
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.43424714
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.33310921
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.84333022
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.77101435
12	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.73251066
13	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.62751104
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.60256043
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.56537891
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.55950314
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.55143972
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.52275350
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.28117176
20	GABP_19822575_ChIP-Seq_HepG2_Human	2.09518047
21	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.08303354
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.01375880
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98459279
24	DCP1A_22483619_ChIP-Seq_HELA_Human	1.98017915
25	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.97428840
26	XRN2_22483619_ChIP-Seq_HELA_Human	1.94149303
27	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.92493494
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.91798559
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.91782336
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.91620430
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.89731058
32	VDR_22108803_ChIP-Seq_LS180_Human	1.72934784
33	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.72615959
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69876358
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.69181838
36	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.60597612
37	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.59904384
38	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.58743081
39	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.57621252
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.57462143
41	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.57125155
42	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.53239797
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.49823069
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44501319
45	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43453360
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.41757982
47	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.41606923
48	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.41351665
49	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.35886257
50	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.34935061
51	CIITA_25753668_ChIP-Seq_RAJI_Human	1.33842198
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.31162737
53	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.29545459
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.29195973
55	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.25944013
56	ZNF263_19887448_ChIP-Seq_K562_Human	1.24795970
57	KDM5A_27292631_Chip-Seq_BREAST_Human	1.23248142
58	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.18082610
59	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.13065421
60	IGF1R_20145208_ChIP-Seq_DFB_Human	1.11958210
61	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.08695996
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.08404271
63	FUS_26573619_Chip-Seq_HEK293_Human	1.08181429
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08172709
65	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.06840382
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06045884
67	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.05664074
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03845476
69	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03313348
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02703099
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02015039
72	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.00120659
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99380490
74	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.99239644
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.99128774
76	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.97576926
77	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.96390135
78	AR_20517297_ChIP-Seq_VCAP_Human	0.95220881
79	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.94615428
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93975256
81	P53_21459846_ChIP-Seq_SAOS-2_Human	0.93326452
82	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.92047343
83	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91495338
84	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91257744
85	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.90631988
86	NCOR_22424771_ChIP-Seq_293T_Human	0.89645816
87	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.89426338
88	ERA_21632823_ChIP-Seq_H3396_Human	0.89235413
89	ERG_20517297_ChIP-Seq_VCAP_Human	0.87942417
90	BCL6_27268052_Chip-Seq_Bcells_Human	0.87420836
91	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.86227695
92	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.86173188
93	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.86103678
94	CTCF_20526341_ChIP-Seq_ESCs_Human	0.85370991
95	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.85370607
96	GATA3_26560356_Chip-Seq_TH2_Human	0.84793984
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84120605
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84120605
99	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.82130147
100	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.81289556

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.62415044
2	MP0005646_abnormal_pituitary_gland	4.04972993
3	MP0005360_urolithiasis	3.41116844
4	MP0003806_abnormal_nucleotide_metabolis	3.37418175
5	MP0006292_abnormal_olfactory_placode	2.92927091
6	MP0006036_abnormal_mitochondrial_physio	2.85999443
7	MP0008875_abnormal_xenobiotic_pharmacok	2.82163552
8	MP0002163_abnormal_gland_morphology	2.44544777
9	MP0001835_abnormal_antigen_presentation	2.23598930
10	MP0002138_abnormal_hepatobiliary_system	2.17296565
11	MP0003693_abnormal_embryo_hatching	2.17206277
12	MP0002876_abnormal_thyroid_physiology	2.14084136
13	MP0002102_abnormal_ear_morphology	2.04967014
14	MP0002837_dystrophic_cardiac_calcinosis	2.03227055
15	MP0003786_premature_aging	1.96962689
16	MP0002234_abnormal_pharynx_morphology	1.93332909
17	MP0008872_abnormal_physiological_respon	1.83085002
18	MP0003186_abnormal_redox_activity	1.80814099
19	MP0004043_abnormal_pH_regulation	1.79636305
20	MP0004142_abnormal_muscle_tone	1.76147456
21	MP0006035_abnormal_mitochondrial_morpho	1.75726157
22	MP0008058_abnormal_DNA_repair	1.75419874
23	MP0001764_abnormal_homeostasis	1.74368328
24	MP0004145_abnormal_muscle_electrophysio	1.67678223
25	MP0005379_endocrine/exocrine_gland_phen	1.61824465
26	MP0001968_abnormal_touch/_nociception	1.58417356
27	MP0004147_increased_porphyrin_level	1.57307256
28	MP0002160_abnormal_reproductive_system	1.56528867
29	MP0001986_abnormal_taste_sensitivity	1.52503594
30	MP0002148_abnormal_hypersensitivity_rea	1.52201408
31	MP0005671_abnormal_response_to	1.50202786
32	MP0003718_maternal_effect	1.46513763
33	MP0002736_abnormal_nociception_after	1.42462983
34	MP0009046_muscle_twitch	1.37671800
35	MP0005389_reproductive_system_phenotype	1.35252621
36	MP0008995_early_reproductive_senescence	1.32479898
37	MP0000372_irregular_coat_pigmentation	1.28602702
38	MP0009333_abnormal_splenocyte_physiolog	1.26832417
39	MP0002277_abnormal_respiratory_mucosa	1.26579855
40	MP0001905_abnormal_dopamine_level	1.26442625
41	MP0005332_abnormal_amino_acid	1.23238751
42	MP0003195_calcinosis	1.21361245
43	MP0001188_hyperpigmentation	1.20976485
44	MP0000685_abnormal_immune_system	1.18584199
45	MP0001348_abnormal_lacrimal_gland	1.18336895
46	MP0008789_abnormal_olfactory_epithelium	1.17734663
47	MP0008007_abnormal_cellular_replicative	1.15606379
48	MP0000681_abnormal_thyroid_gland	1.13677202
49	MP0008877_abnormal_DNA_methylation	1.12206176
50	MP0000678_abnormal_parathyroid_gland	1.12041460
51	MP0005410_abnormal_fertilization	1.09741557
52	MP0001800_abnormal_humoral_immune	1.08108125
53	MP0005645_abnormal_hypothalamus_physiol	1.07630190
54	MP0006276_abnormal_autonomic_nervous	1.07556852
55	MP0005551_abnormal_eye_electrophysiolog	1.07289032
56	MP0000631_abnormal_neuroendocrine_gland	1.06874824
57	MP0004885_abnormal_endolymph	1.03352093
58	MP0001529_abnormal_vocalization	1.01892345
59	MP0005670_abnormal_white_adipose	1.00802487
60	MP0009697_abnormal_copulation	1.00084304
61	MP0003646_muscle_fatigue	0.98300126
62	MP0001881_abnormal_mammary_gland	0.97753244
63	MP0008775_abnormal_heart_ventricle	0.97333237
64	MP0000049_abnormal_middle_ear	0.96313486
65	MP0001919_abnormal_reproductive_system	0.95996453
66	MP0001756_abnormal_urination	0.94214245
67	MP0009765_abnormal_xenobiotic_induced	0.92705903
68	MP0002272_abnormal_nervous_system	0.92360439
69	MP0003315_abnormal_perineum_morphology	0.91381264
70	MP0006072_abnormal_retinal_apoptosis	0.89430387
71	MP0008873_increased_physiological_sensi	0.88753235
72	MP0009764_decreased_sensitivity_to	0.88205166
73	MP0005084_abnormal_gallbladder_morpholo	0.88125049
74	MP0002733_abnormal_thermal_nociception	0.86684841
75	MP0000013_abnormal_adipose_tissue	0.86469580
76	MP0003567_abnormal_fetal_cardiomyocyte	0.86330488
77	MP0005085_abnormal_gallbladder_physiolo	0.85481637
78	MP0005499_abnormal_olfactory_system	0.82855652
79	MP0005394_taste/olfaction_phenotype	0.82855652
80	MP0005636_abnormal_mineral_homeostasis	0.82694242
81	MP0003724_increased_susceptibility_to	0.80192449
82	MP0009745_abnormal_behavioral_response	0.79650908
83	MP0000538_abnormal_urinary_bladder	0.78222775
84	MP0001970_abnormal_pain_threshold	0.77331155
85	MP0001790_abnormal_immune_system	0.75672802
86	MP0005387_immune_system_phenotype	0.75672802
87	MP0003787_abnormal_imprinting	0.75298739
88	MP0003866_abnormal_defecation	0.74796447
89	MP0005319_abnormal_enzyme/_coenzyme	0.73461346
90	MP0001270_distended_abdomen	0.72220242
91	MP0005253_abnormal_eye_physiology	0.72007630
92	MP0002723_abnormal_immune_serum	0.71441313
93	MP0004782_abnormal_surfactant_physiolog	0.70029858
94	MP0001293_anophthalmia	0.69888884
95	MP0002452_abnormal_antigen_presenting	0.68911432
96	MP0005000_abnormal_immune_tolerance	0.68726794
97	MP0001873_stomach_inflammation	0.68604685
98	MP0009643_abnormal_urine_homeostasis	0.68591591
99	MP0005647_abnormal_sex_gland	0.68307692
100	MP0008932_abnormal_embryonic_tissue	0.68060507

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.51556204
2	Mitochondrial inheritance (HP:0001427)	5.14133059
3	Abnormal mitochondria in muscle tissue (HP:0008316)	5.05823119
4	Acute encephalopathy (HP:0006846)	4.87659548
5	Increased CSF lactate (HP:0002490)	4.73330479
6	3-Methylglutaconic aciduria (HP:0003535)	4.71713450
7	Progressive macrocephaly (HP:0004481)	4.53355962
8	Hepatocellular necrosis (HP:0001404)	4.42799923
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.42785440
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.42785440
11	Hepatic necrosis (HP:0002605)	4.40721331
12	Abnormal number of erythroid precursors (HP:0012131)	3.92338673
13	Increased hepatocellular lipid droplets (HP:0006565)	3.81909885
14	Increased serum lactate (HP:0002151)	3.72193208
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.70616889
16	Cerebral edema (HP:0002181)	3.67665529
17	Lactic acidosis (HP:0003128)	3.65549619
18	Lipid accumulation in hepatocytes (HP:0006561)	3.55913330
19	Renal Fanconi syndrome (HP:0001994)	3.53141947
20	Increased intramyocellular lipid droplets (HP:0012240)	3.51500747
21	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.26527854
22	Testicular atrophy (HP:0000029)	3.21336489
23	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.15574978
24	Increased muscle lipid content (HP:0009058)	2.99479224
25	Respiratory failure (HP:0002878)	2.92188169
26	Generalized aminoaciduria (HP:0002909)	2.88083709
27	Optic disc pallor (HP:0000543)	2.85119692
28	Type II lissencephaly (HP:0007260)	2.84843265
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.75982048
30	Macrocytic anemia (HP:0001972)	2.75912720
31	Congenital stationary night blindness (HP:0007642)	2.75883578
32	Exercise intolerance (HP:0003546)	2.71963209
33	Reticulocytopenia (HP:0001896)	2.62380577
34	Exertional dyspnea (HP:0002875)	2.59620034
35	Lethargy (HP:0001254)	2.53074263
36	Renal cortical cysts (HP:0000803)	2.52999144
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.51270333
38	Abnormality of alanine metabolism (HP:0010916)	2.51270333
39	Hyperalaninemia (HP:0003348)	2.51270333
40	Progressive microcephaly (HP:0000253)	2.50003814
41	Pancreatic fibrosis (HP:0100732)	2.48825841
42	Microvesicular hepatic steatosis (HP:0001414)	2.45771948
43	Abnormality of magnesium homeostasis (HP:0004921)	2.45725644
44	Pancreatic cysts (HP:0001737)	2.44558371
45	Hypoplasia of the uterus (HP:0000013)	2.43227894
46	Type 2 muscle fiber atrophy (HP:0003554)	2.42699938
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.40559499
48	Leukodystrophy (HP:0002415)	2.40543243
49	Molar tooth sign on MRI (HP:0002419)	2.40189730
50	Abnormality of midbrain morphology (HP:0002418)	2.40189730
51	Abnormality of the renal cortex (HP:0011035)	2.37084800
52	Glycosuria (HP:0003076)	2.35361993
53	Abnormality of urine glucose concentration (HP:0011016)	2.35361993
54	Colon cancer (HP:0003003)	2.34121021
55	Stomatitis (HP:0010280)	2.33761551
56	Hyperglycinemia (HP:0002154)	2.28817121
57	Muscle fiber atrophy (HP:0100295)	2.27118191
58	Hypomagnesemia (HP:0002917)	2.21502670
59	Elevated erythrocyte sedimentation rate (HP:0003565)	2.19854174
60	Abolished electroretinogram (ERG) (HP:0000550)	2.18686860
61	Absent thumb (HP:0009777)	2.15686461
62	Severe muscular hypotonia (HP:0006829)	2.14773021
63	Aplasia/hypoplasia of the uterus (HP:0008684)	2.12355020
64	Microretrognathia (HP:0000308)	2.12206369
65	Reduced antithrombin III activity (HP:0001976)	2.11919122
66	Cerebellar dysplasia (HP:0007033)	2.11175382
67	Type I transferrin isoform profile (HP:0003642)	2.08967391
68	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03764654
69	Absent/shortened dynein arms (HP:0200106)	2.03764654
70	Cleft eyelid (HP:0000625)	2.01344810
71	True hermaphroditism (HP:0010459)	1.93310751
72	Hyperglycinuria (HP:0003108)	1.93057300
73	CNS demyelination (HP:0007305)	1.91866181
74	Pallor (HP:0000980)	1.91626886
75	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.89884887
76	Abnormality of T cell physiology (HP:0011840)	1.89864808
77	Respiratory difficulties (HP:0002880)	1.86416352
78	Abnormality of renal resorption (HP:0011038)	1.84319151
79	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.84098554
80	Dicarboxylic aciduria (HP:0003215)	1.84098554
81	IgG deficiency (HP:0004315)	1.83732722
82	Hyperphosphaturia (HP:0003109)	1.81739186
83	Sclerocornea (HP:0000647)	1.81572046
84	Abnormal rod and cone electroretinograms (HP:0008323)	1.81273744
85	Nausea (HP:0002018)	1.79268618
86	Nephronophthisis (HP:0000090)	1.75982867
87	Occipital encephalocele (HP:0002085)	1.75223631
88	Decreased central vision (HP:0007663)	1.75109441
89	Abnormal respiratory epithelium morphology (HP:0012253)	1.74657457
90	Abnormal respiratory motile cilium morphology (HP:0005938)	1.74657457
91	Constricted visual fields (HP:0001133)	1.74537626
92	Redundant skin (HP:0001582)	1.73348512
93	Aplastic anemia (HP:0001915)	1.71347048
94	Death in infancy (HP:0001522)	1.70291744
95	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.66703919
96	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.66041322
97	Abnormal protein N-linked glycosylation (HP:0012347)	1.66041322
98	Abnormal protein glycosylation (HP:0012346)	1.66041322
99	Abnormal glycosylation (HP:0012345)	1.66041322
100	Congenital, generalized hypertrichosis (HP:0004540)	1.65853194

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.00702952
2	TLK1	3.44696091
3	BCKDK	3.41956027
4	ZAK	3.30859491
5	TAOK3	3.26575615
6	EIF2AK1	2.83663277
7	NUAK1	2.38990726
8	VRK2	2.32985228
9	ADRBK2	2.31967521
10	GRK1	2.06083216
11	WNK4	2.03976903
12	BMPR1B	1.79936786
13	TXK	1.76624617
14	STK16	1.73519675
15	CDK8	1.70430541
16	MAP4K2	1.70014810
17	TIE1	1.64251636
18	MST4	1.60853818
19	IKBKB	1.53267241
20	PBK	1.48827148
21	KIT	1.48041961
22	RPS6KA5	1.40855285
23	PDK2	1.31252021
24	VRK1	1.31235917
25	TEC	1.29381934
26	PHKG2	1.27960231
27	PHKG1	1.27960231
28	MAP3K13	1.27825178
29	MAPKAPK3	1.24136609
30	CAMKK2	1.22259786
31	PINK1	1.21395261
32	MKNK1	1.20560781
33	DYRK2	1.19473626
34	ITK	1.18016367
35	IKBKE	1.17517080
36	FES	1.16138246
37	MAP3K14	1.01001340
38	MAPKAPK5	1.00004829
39	ABL2	0.97712982
40	KDR	0.95846941
41	TNK2	0.95629081
42	BUB1	0.95615191
43	SRPK1	0.94811324
44	DAPK1	0.94065970
45	FRK	0.88950745
46	EIF2AK3	0.87967819
47	FLT3	0.82743081
48	TYK2	0.81862506
49	NME1	0.80746668
50	OXSR1	0.77643595
51	CSNK1G3	0.76738883
52	TSSK6	0.76322811
53	SYK	0.76222336
54	MAP4K1	0.74952826
55	GRK6	0.74409595
56	INSRR	0.74159952
57	ADRBK1	0.68436944
58	MAP3K12	0.67358973
59	EIF2AK2	0.66200811
60	DAPK2	0.66030761
61	CSNK1G2	0.65805545
62	PLK4	0.65169199
63	MAP2K6	0.64969482
64	CSNK2A2	0.63804214
65	PRKCQ	0.63769030
66	ILK	0.62037229
67	MAP3K11	0.61246483
68	CSNK2A1	0.61181880
69	GRK5	0.60140973
70	TGFBR1	0.59191119
71	OBSCN	0.58007462
72	CSNK1A1L	0.57322989
73	PRKCG	0.57276510
74	CSF1R	0.54255806
75	ATR	0.54080791
76	PIK3CA	0.53173716
77	BTK	0.52828870
78	PRKG2	0.52364793
79	AURKB	0.51703759
80	LYN	0.50458773
81	PIM2	0.45916058
82	LRRK2	0.45523193
83	CDC7	0.44460278
84	STK4	0.44364616
85	CSNK1A1	0.43343322
86	TAF1	0.43189631
87	MAP2K2	0.42091990
88	CSNK1G1	0.42055002
89	WNK3	0.41873839
90	CHEK2	0.41685127
91	PLK1	0.39965715
92	STK39	0.39788671
93	PRKCI	0.37687919
94	PRKCA	0.37448921
95	PRKCD	0.37015574
96	TRIM28	0.34873077
97	MATK	0.34083656
98	TBK1	0.34079735
99	PRKACA	0.32460360
100	AURKA	0.32037060

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.90147263
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.20146839
3	Parkinsons disease_Homo sapiens_hsa05012	3.74311220
4	Asthma_Homo sapiens_hsa05310	3.24131043
5	RNA polymerase_Homo sapiens_hsa03020	2.86677777
6	Proteasome_Homo sapiens_hsa03050	2.70269414
7	Allograft rejection_Homo sapiens_hsa05330	2.59850218
8	Huntingtons disease_Homo sapiens_hsa05016	2.45616151
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.42902600
10	Alzheimers disease_Homo sapiens_hsa05010	2.42554777
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.37089803
12	One carbon pool by folate_Homo sapiens_hsa00670	2.35272994
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.22149258
14	Protein export_Homo sapiens_hsa03060	1.95446573
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86207005
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.85778525
17	DNA replication_Homo sapiens_hsa03030	1.78202269
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72913804
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.70759896
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.70142103
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.60586458
22	Mismatch repair_Homo sapiens_hsa03430	1.60108076
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.53881010
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50626026
25	RNA degradation_Homo sapiens_hsa03018	1.47309699
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.43680064
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.42404619
28	Homologous recombination_Homo sapiens_hsa03440	1.41337013
29	Sulfur metabolism_Homo sapiens_hsa00920	1.41144108
30	Spliceosome_Homo sapiens_hsa03040	1.38337813
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34749982
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23271291
33	Propanoate metabolism_Homo sapiens_hsa00640	1.21279788
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16697621
35	Purine metabolism_Homo sapiens_hsa00230	1.16206943
36	Base excision repair_Homo sapiens_hsa03410	1.12978942
37	Sulfur relay system_Homo sapiens_hsa04122	1.11927839
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07417415
39	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.00453678
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.99255977
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.95317555
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95168819
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93226390
44	Phototransduction_Homo sapiens_hsa04744	0.90126676
45	RNA transport_Homo sapiens_hsa03013	0.89184301
46	Fatty acid elongation_Homo sapiens_hsa00062	0.88491160
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88433809
48	Primary immunodeficiency_Homo sapiens_hsa05340	0.84743058
49	Rheumatoid arthritis_Homo sapiens_hsa05323	0.82789464
50	Antigen processing and presentation_Homo sapiens_hsa04612	0.82275264
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.80995241
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79863213
53	Metabolic pathways_Homo sapiens_hsa01100	0.78144054
54	Folate biosynthesis_Homo sapiens_hsa00790	0.74351900
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.72181643
56	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.69158429
57	Viral myocarditis_Homo sapiens_hsa05416	0.65000927
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.62385757
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61821176
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.61382476
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.61077610
62	Basal transcription factors_Homo sapiens_hsa03022	0.59470933
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58257593
64	Peroxisome_Homo sapiens_hsa04146	0.57684023
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54493269
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.54235348
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.53679868
68	Butanoate metabolism_Homo sapiens_hsa00650	0.50177188
69	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.46741896
70	Caffeine metabolism_Homo sapiens_hsa00232	0.46151791
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.46024134
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45937882
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45193516
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44870969
75	Leishmaniasis_Homo sapiens_hsa05140	0.40638232
76	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.39891116
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38365610
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38322752
79	Retinol metabolism_Homo sapiens_hsa00830	0.37778517
80	Olfactory transduction_Homo sapiens_hsa04740	0.35598654
81	Regulation of autophagy_Homo sapiens_hsa04140	0.33438798
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31677889
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31524647
84	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.31182031
85	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.31043806
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.30882123
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.30080470
88	Fatty acid degradation_Homo sapiens_hsa00071	0.30079120
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29263789
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28860237
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28475993
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.27666916
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.25651615
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.24651317
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.23060232
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.22240529
97	Glutathione metabolism_Homo sapiens_hsa00480	0.20300106
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.19961024
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.18788147
100	Carbon metabolism_Homo sapiens_hsa01200	0.18398051

RPS4XP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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