RPS4Y2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ribosomal protein that is highly similar to RPS4Y1. This gene is located in the male-specific region of the Y chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)8.13512478
2dendritic spine morphogenesis (GO:0060997)6.40881555
3B cell mediated immunity (GO:0019724)6.24440269
4positive thymic T cell selection (GO:0045059)6.09269631
5chaperone mediated protein folding requiring cofactor (GO:0051085)5.99108696
6L-fucose catabolic process (GO:0042355)5.05381552
7fucose catabolic process (GO:0019317)5.05381552
8L-fucose metabolic process (GO:0042354)5.05381552
9brain morphogenesis (GO:0048854)4.93423389
10negative regulation of granulocyte differentiation (GO:0030853)4.91361458
11regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.88193604
12transcription from mitochondrial promoter (GO:0006390)4.80811375
13regulation of oxidative stress-induced neuron death (GO:1903203)4.80029279
14auditory behavior (GO:0031223)4.73531432
15prostate gland growth (GO:0060736)4.66807149
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.66468814
17positive T cell selection (GO:0043368)4.64427260
18positive regulation of protein homodimerization activity (GO:0090073)4.53845533
19neurotransmitter-gated ion channel clustering (GO:0072578)4.46646987
20negative regulation of protein oligomerization (GO:0032460)4.44801682
21regulation of synapse structural plasticity (GO:0051823)4.19491900
22response to auditory stimulus (GO:0010996)4.03288676
23phospholipid translocation (GO:0045332)3.99623585
24lipid translocation (GO:0034204)3.99623585
25negative regulation of defense response to virus (GO:0050687)3.98415532
26cytokine biosynthetic process (GO:0042089)3.90218223
27platelet dense granule organization (GO:0060155)3.84921524
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.81378976
29response to lipoprotein particle (GO:0055094)3.71684708
30gonadal mesoderm development (GO:0007506)3.63930088
31behavioral response to nicotine (GO:0035095)3.59589344
32interferon-gamma-mediated signaling pathway (GO:0060333)3.56396380
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.52168405
34forebrain morphogenesis (GO:0048853)3.46002099
35respiratory chain complex IV assembly (GO:0008535)3.44095488
36negative regulation of B cell apoptotic process (GO:0002903)3.38128894
37protein neddylation (GO:0045116)3.37100942
38regulation of nuclear cell cycle DNA replication (GO:0033262)3.31686878
39regulation of cilium movement (GO:0003352)3.28404404
40regulation of B cell apoptotic process (GO:0002902)3.26423728
41positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.23466957
42cytokine metabolic process (GO:0042107)3.22168234
43protein import into peroxisome matrix (GO:0016558)3.20340738
44mechanosensory behavior (GO:0007638)3.17884634
45mitochondrial RNA metabolic process (GO:0000959)3.17525642
46negative regulation of actin filament bundle assembly (GO:0032232)3.17052764
47artery smooth muscle contraction (GO:0014824)3.14008391
48cytochrome complex assembly (GO:0017004)3.11799753
49positive regulation of interleukin-17 production (GO:0032740)3.11003951
50detection of light stimulus involved in sensory perception (GO:0050962)3.09344834
51detection of light stimulus involved in visual perception (GO:0050908)3.09344834
52response to interferon-beta (GO:0035456)3.07849219
53negative regulation of response to food (GO:0032096)3.04838671
54negative regulation of appetite (GO:0032099)3.04838671
55positive regulation of vesicle fusion (GO:0031340)3.03097439
56preassembly of GPI anchor in ER membrane (GO:0016254)3.00292768
57maturation of 5.8S rRNA (GO:0000460)2.96399726
58cellular response to leptin stimulus (GO:0044320)2.93180973
59drug metabolic process (GO:0017144)2.92608998
60dendritic spine organization (GO:0097061)2.91755884
61replicative senescence (GO:0090399)2.87892723
62cellular response to ethanol (GO:0071361)2.87682781
63left/right pattern formation (GO:0060972)2.84427657
64synaptic transmission, cholinergic (GO:0007271)2.83882941
65negative regulation of mast cell activation (GO:0033004)2.83879215
66negative regulation of type I interferon production (GO:0032480)2.81900846
67cellular response to exogenous dsRNA (GO:0071360)2.81405964
68cellular response to interferon-gamma (GO:0071346)2.78657976
69ribosome assembly (GO:0042255)2.74914440
70activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.73930919
71vocalization behavior (GO:0071625)2.72505475
72regulation of triglyceride biosynthetic process (GO:0010866)2.71252424
73negative regulation of telomere maintenance (GO:0032205)2.70840837
74male meiosis I (GO:0007141)2.70641226
75nephron tubule morphogenesis (GO:0072078)2.70560690
76nephron epithelium morphogenesis (GO:0072088)2.70560690
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.65953522
78regulation of protein homooligomerization (GO:0032462)2.65768371
79tonic smooth muscle contraction (GO:0014820)2.64563734
80negative regulation of phagocytosis (GO:0050765)2.63773119
81glyoxylate metabolic process (GO:0046487)2.63547835
82mast cell activation involved in immune response (GO:0002279)2.62892334
83mast cell degranulation (GO:0043303)2.62892334
84thymic T cell selection (GO:0045061)2.62864411
85synaptic vesicle maturation (GO:0016188)2.60424239
86regulation of interferon-beta production (GO:0032648)2.59602316
87response to xenobiotic stimulus (GO:0009410)2.58643851
88adaptation of signaling pathway (GO:0023058)2.56816620
89negative regulation of thymocyte apoptotic process (GO:0070244)2.56771503
90response to muscle activity (GO:0014850)2.55588673
91protein K48-linked ubiquitination (GO:0070936)2.55434530
92detection of mechanical stimulus involved in sensory perception (GO:0050974)2.53923804
93positive regulation of antigen processing and presentation (GO:0002579)2.53297711
94negative regulation of digestive system process (GO:0060457)2.52473539
95RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52356639
96positive regulation by host of viral transcription (GO:0043923)2.52013191
97vascular smooth muscle contraction (GO:0014829)2.51861024
98positive regulation of chemokine biosynthetic process (GO:0045080)2.51733054
99adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.50869400
100positive regulation of response to oxidative stress (GO:1902884)2.50452367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.33301312
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.97812569
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.37641278
4ZNF274_21170338_ChIP-Seq_K562_Hela3.35521160
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18759962
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83070921
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.57818805
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53133872
9VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.33493478
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31711796
11IRF1_19129219_ChIP-ChIP_H3396_Human2.29091805
12GATA3_26560356_Chip-Seq_TH2_Human2.22255733
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.08800841
14EGR1_19032775_ChIP-ChIP_M12_Human1.97527823
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97085021
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95925634
17IRF8_21731497_ChIP-ChIP_J774_Mouse1.95507321
18ETV2_25802403_ChIP-Seq_MESCs_Mouse1.80836411
19SCL_19346495_ChIP-Seq_HPC-7_Human1.71346786
20TP53_22573176_ChIP-Seq_HFKS_Human1.59687512
21CIITA_25753668_ChIP-Seq_RAJI_Human1.59045883
22MYC_18940864_ChIP-ChIP_HL60_Human1.58446524
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53714617
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53714617
25GATA3_27048872_Chip-Seq_THYMUS_Human1.44510305
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44365818
27STAT1_20625510_ChIP-Seq_HELA_Human1.39553170
28VDR_24787735_ChIP-Seq_THP-1_Human1.38513596
29NANOG_19829295_ChIP-Seq_ESCs_Human1.38469511
30SOX2_19829295_ChIP-Seq_ESCs_Human1.38469511
31RUNX_20019798_ChIP-Seq_JUKART_Human1.37461332
32FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35332432
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33066102
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32733834
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32445966
36EZH2_22144423_ChIP-Seq_EOC_Human1.32424746
37P300_19829295_ChIP-Seq_ESCs_Human1.31517198
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31166982
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.26251769
40TAF2_19829295_ChIP-Seq_ESCs_Human1.23697547
41TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23214816
42HOXB7_26014856_ChIP-Seq_BT474_Human1.23091146
43PRDM14_20953172_ChIP-Seq_ESCs_Human1.21943052
44NCOR_22424771_ChIP-Seq_293T_Human1.21930638
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.20646986
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20646986
47GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.20525106
48MYB_26560356_Chip-Seq_TH2_Human1.20305684
49GBX2_23144817_ChIP-Seq_PC3_Human1.19255030
50GATA3_26560356_Chip-Seq_TH1_Human1.19014147
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18218023
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16285068
53FOXH1_21741376_ChIP-Seq_EPCs_Human1.16244963
54TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.15910674
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15593346
56E2F1_20622854_ChIP-Seq_HELA_Human1.12035840
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.11674791
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.10912974
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10893173
60FOXP3_21729870_ChIP-Seq_TREG_Human1.08017473
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07675653
62ER_23166858_ChIP-Seq_MCF-7_Human1.07153466
63SPI1_20517297_ChIP-Seq_HL60_Human1.07059988
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07041722
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05366185
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05215421
67TCF4_23295773_ChIP-Seq_U87_Human1.04693177
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03951205
69BCAT_22108803_ChIP-Seq_LS180_Human1.02890015
70RXR_22108803_ChIP-Seq_LS180_Human1.01567524
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01191664
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00633043
73SALL1_21062744_ChIP-ChIP_HESCs_Human0.99526225
74OCT4_20526341_ChIP-Seq_ESCs_Human0.99293294
75VDR_22108803_ChIP-Seq_LS180_Human0.99140658
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98602875
77POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98427432
78MYC_19829295_ChIP-Seq_ESCs_Human0.96459845
79P300_27268052_Chip-Seq_Bcells_Human0.96298069
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95853999
81MYB_26560356_Chip-Seq_TH1_Human0.95638988
82STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95312248
83RAC3_21632823_ChIP-Seq_H3396_Human0.95041193
84CEBPB_22108803_ChIP-Seq_LS180_Human0.94857033
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94407895
86TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93902457
87VDR_24763502_ChIP-Seq_THP-1_Human0.93818748
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93807732
89FUS_26573619_Chip-Seq_HEK293_Human0.93523051
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89846727
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89841737
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88441823
93TP53_22127205_ChIP-Seq_IMR90_Human0.88380372
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.88232804
95SPI1_23547873_ChIP-Seq_NB4_Human0.88100269
96RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87882607
97CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86829384
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84144115
99EWS_26573619_Chip-Seq_HEK293_Human0.83715082
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.82335500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.91435503
2MP0004084_abnormal_cardiac_muscle3.48896117
3MP0005220_abnormal_exocrine_pancreas3.44145649
4MP0002138_abnormal_hepatobiliary_system3.27184538
5MP0006292_abnormal_olfactory_placode3.18284925
6MP0003123_paternal_imprinting3.05985942
7MP0009764_decreased_sensitivity_to2.56721381
8MP0008775_abnormal_heart_ventricle2.38078034
9MP0009278_abnormal_bone_marrow2.36825299
10MP0001986_abnormal_taste_sensitivity2.36455846
11MP0008007_abnormal_cellular_replicative2.35354577
12MP0010368_abnormal_lymphatic_system2.28714015
13MP0003567_abnormal_fetal_cardiomyocyte2.25206421
14MP0004782_abnormal_surfactant_physiolog2.13994397
15MP0009697_abnormal_copulation2.09232068
16MP0002166_altered_tumor_susceptibility2.09023306
17MP0002148_abnormal_hypersensitivity_rea2.02545286
18MP0001501_abnormal_sleep_pattern2.02428959
19MP0004043_abnormal_pH_regulation2.01394915
20MP0003075_altered_response_to2.00353985
21MP0001790_abnormal_immune_system1.95885704
22MP0005387_immune_system_phenotype1.95885704
23MP0010155_abnormal_intestine_physiology1.92451574
24MP0008875_abnormal_xenobiotic_pharmacok1.90583688
25MP0005360_urolithiasis1.84942640
26MP0003172_abnormal_lysosome_physiology1.82983335
27MP0005167_abnormal_blood-brain_barrier1.76800192
28MP0005464_abnormal_platelet_physiology1.73481671
29MP0005646_abnormal_pituitary_gland1.70893195
30MP0003195_calcinosis1.70501846
31MP0003646_muscle_fatigue1.70357934
32MP0001984_abnormal_olfaction1.69735896
33MP0000604_amyloidosis1.65435626
34MP0001800_abnormal_humoral_immune1.62127263
35MP0000685_abnormal_immune_system1.58440034
36MP0002006_tumorigenesis1.57489183
37MP0005647_abnormal_sex_gland1.54590144
38MP0005671_abnormal_response_to1.50996155
39MP0003191_abnormal_cellular_cholesterol1.48275064
40MP0008789_abnormal_olfactory_epithelium1.45081982
41MP0009785_altered_susceptibility_to1.42828555
42MP0001529_abnormal_vocalization1.35066637
43MP0004036_abnormal_muscle_relaxation1.34465381
44MP0000230_abnormal_systemic_arterial1.33252784
45MP0002876_abnormal_thyroid_physiology1.28605593
46MP0006072_abnormal_retinal_apoptosis1.23235101
47MP0008872_abnormal_physiological_respon1.18575635
48MP0005165_increased_susceptibility_to1.14044966
49MP0005397_hematopoietic_system_phenotyp1.13661005
50MP0001545_abnormal_hematopoietic_system1.13661005
51MP0002723_abnormal_immune_serum1.12574257
52MP0004133_heterotaxia1.12355182
53MP0008877_abnormal_DNA_methylation1.09066314
54MP0002102_abnormal_ear_morphology1.08818520
55MP0002452_abnormal_antigen_presenting1.08557585
56MP0004215_abnormal_myocardial_fiber1.08380736
57MP0000470_abnormal_stomach_morphology1.07386520
58MP0005595_abnormal_vascular_smooth1.05890492
59MP0005389_reproductive_system_phenotype1.05791936
60MP0010329_abnormal_lipoprotein_level1.05521495
61MP0005386_behavior/neurological_phenoty1.04964365
62MP0004924_abnormal_behavior1.04964365
63MP0002420_abnormal_adaptive_immunity1.03487780
64MP0003950_abnormal_plasma_membrane1.03074169
65MP0000427_abnormal_hair_cycle1.00670690
66MP0001819_abnormal_immune_cell1.00430976
67MP0002419_abnormal_innate_immunity0.97782252
68MP0005000_abnormal_immune_tolerance0.94462525
69MP0001968_abnormal_touch/_nociception0.91242410
70MP0002160_abnormal_reproductive_system0.89717032
71MP0000716_abnormal_immune_system0.89379862
72MP0005394_taste/olfaction_phenotype0.88711531
73MP0005499_abnormal_olfactory_system0.88711531
74MP0002909_abnormal_adrenal_gland0.87470363
75MP0001485_abnormal_pinna_reflex0.86111673
76MP0002127_abnormal_cardiovascular_syste0.84572250
77MP0002398_abnormal_bone_marrow0.84343179
78MP0003186_abnormal_redox_activity0.82774785
79MP0002928_abnormal_bile_duct0.82740722
80MP0001845_abnormal_inflammatory_respons0.82392745
81MP0001879_abnormal_lymphatic_vessel0.81753959
82MP0001853_heart_inflammation0.80383565
83MP0005085_abnormal_gallbladder_physiolo0.79060361
84MP0005025_abnormal_response_to0.77966250
85MP0000372_irregular_coat_pigmentation0.77920948
86MP0006276_abnormal_autonomic_nervous0.77352288
87MP0002733_abnormal_thermal_nociception0.75462438
88MP0003121_genomic_imprinting0.74342368
89MP0000689_abnormal_spleen_morphology0.74325832
90MP0008469_abnormal_protein_level0.73279272
91MP0002332_abnormal_exercise_endurance0.72087266
92MP0001544_abnormal_cardiovascular_syste0.71624016
93MP0005385_cardiovascular_system_phenoty0.71624016
94MP0002837_dystrophic_cardiac_calcinosis0.70493306
95MP0000490_abnormal_crypts_of0.70268009
96MP0000249_abnormal_blood_vessel0.70020208
97MP0001905_abnormal_dopamine_level0.69806575
98MP0003252_abnormal_bile_duct0.69556622
99MP0005253_abnormal_eye_physiology0.69534200
100MP0004883_abnormal_blood_vessel0.68798949

Predicted human phenotypes

RankGene SetZ-score
1Fair hair (HP:0002286)5.76858616
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.72124574
3Stomach cancer (HP:0012126)5.53742578
4Delayed CNS myelination (HP:0002188)5.25364605
5Short chin (HP:0000331)4.93464910
6Increased IgM level (HP:0003496)4.78383964
7Broad-based gait (HP:0002136)4.58537675
8Clumsiness (HP:0002312)4.52637051
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.49902294
10Elevated erythrocyte sedimentation rate (HP:0003565)4.27466300
11Renal cortical cysts (HP:0000803)4.22620588
12Generalized hypopigmentation of hair (HP:0011358)4.20389096
13Abnormality of calcium-phosphate metabolism (HP:0100530)3.99453338
14Abnormality of the periventricular white matter (HP:0002518)3.98054702
15Tubulointerstitial nephritis (HP:0001970)3.92766067
16Agammaglobulinemia (HP:0004432)3.82210986
17Abnormality of the renal cortex (HP:0011035)3.69449042
18Hyperphosphatemia (HP:0002905)3.67279198
19Progressive macrocephaly (HP:0004481)3.60904013
20Panhypogammaglobulinemia (HP:0003139)3.18572627
21Acute necrotizing encephalopathy (HP:0006965)3.14071141
22Hyperkalemia (HP:0002153)3.08174611
23Pulmonary infiltrates (HP:0002113)2.94532082
24Abnormality of T cell physiology (HP:0011840)2.86941380
25Protruding tongue (HP:0010808)2.81742370
26Absent speech (HP:0001344)2.76425955
27Abnormal mitochondria in muscle tissue (HP:0008316)2.76296613
28Poor eye contact (HP:0000817)2.74972459
29Autoimmune thrombocytopenia (HP:0001973)2.72518162
30Abnormality of B cell number (HP:0010975)2.68861124
31Polygenic inheritance (HP:0010982)2.65479237
32Attenuation of retinal blood vessels (HP:0007843)2.61954119
33Acute encephalopathy (HP:0006846)2.61213743
34Recurrent cutaneous fungal infections (HP:0011370)2.55605691
35Chronic mucocutaneous candidiasis (HP:0002728)2.55605691
36Pendular nystagmus (HP:0012043)2.53767911
37Abnormality of the pleura (HP:0002103)2.51325219
38Abnormality of the renal medulla (HP:0100957)2.49921194
39Abolished electroretinogram (ERG) (HP:0000550)2.49121480
40Bulbous nose (HP:0000414)2.48069579
41Enlarged kidneys (HP:0000105)2.47606667
42Widely spaced teeth (HP:0000687)2.47525760
43Tubulointerstitial abnormality (HP:0001969)2.38924662
442-3 toe syndactyly (HP:0004691)2.38829433
45Hematochezia (HP:0002573)2.34999851
46Rectovaginal fistula (HP:0000143)2.34707679
47Rectal fistula (HP:0100590)2.34707679
48Medial flaring of the eyebrow (HP:0010747)2.29999245
49Optic disc pallor (HP:0000543)2.29449669
50Inability to walk (HP:0002540)2.28933800
51Septate vagina (HP:0001153)2.28175570
52Viral hepatitis (HP:0006562)2.26444209
53Pancreatic cysts (HP:0001737)2.25213958
54Periorbital edema (HP:0100539)2.23909849
55Macroglossia (HP:0000158)2.23635264
56Amelogenesis imperfecta (HP:0000705)2.23310754
57Prolonged QT interval (HP:0001657)2.18321467
58Impaired social interactions (HP:0000735)2.13775738
59Abnormal social behavior (HP:0012433)2.13775738
60Facial edema (HP:0000282)2.09647412
61Pancreatic fibrosis (HP:0100732)2.08167751
62Recurrent fungal infections (HP:0002841)2.07117523
63Congenital hepatic fibrosis (HP:0002612)2.05935912
64Abnormality of the prostate (HP:0008775)2.04905094
65Abnormality of T cells (HP:0002843)2.03395033
66Concave nail (HP:0001598)2.01618008
67Urticaria (HP:0001025)2.00549346
68Hemoptysis (HP:0002105)1.99872753
69Exotropia (HP:0000577)1.98730420
70Congenital, generalized hypertrichosis (HP:0004540)1.98128858
71Hyperventilation (HP:0002883)1.96135749
72Meningitis (HP:0001287)1.94416176
73Type II lissencephaly (HP:0007260)1.94373221
74Alveolar cell carcinoma (HP:0006519)1.93682400
75Hypomagnesemia (HP:0002917)1.93238412
76Polydipsia (HP:0001959)1.90575567
77Abnormal drinking behavior (HP:0030082)1.90575567
78Large eyes (HP:0001090)1.90314533
79Mitochondrial inheritance (HP:0001427)1.88916898
80Multifactorial inheritance (HP:0001426)1.87315039
81Hamartoma of the eye (HP:0010568)1.85447828
82Intestinal fistula (HP:0100819)1.82085771
833-Methylglutaconic aciduria (HP:0003535)1.81334303
84Eosinophilia (HP:0001880)1.80839064
85Vaginal fistula (HP:0004320)1.80711730
86Stomatitis (HP:0010280)1.80138445
87Sporadic (HP:0003745)1.78185571
88Respiratory failure (HP:0002878)1.76767818
89Tubular atrophy (HP:0000092)1.76618584
90Increased CSF lactate (HP:0002490)1.75423296
91Cellulitis (HP:0100658)1.75330335
92Retrobulbar optic neuritis (HP:0100654)1.74980488
93Optic neuritis (HP:0100653)1.74980488
94Autoimmune hemolytic anemia (HP:0001890)1.73435656
95Blue irides (HP:0000635)1.72898670
96Lymphedema (HP:0001004)1.72855784
97Abnormality of T cell number (HP:0011839)1.70751559
98Hypergammaglobulinemia (HP:0010702)1.70730221
99Postaxial foot polydactyly (HP:0001830)1.70146006
100Cystic liver disease (HP:0006706)1.69515408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K106.40947280
2BMPR1B4.69725187
3WNK44.34168165
4FRK4.05692979
5ADRBK23.16636546
6TGFBR12.72699231
7CDK82.51675288
8TLK12.06150061
9TEC2.02978343
10DAPK22.00900572
11SCYL21.98819055
12ZAK1.98502786
13KIT1.97891067
14STK381.81102965
15PLK21.78981789
16MAP4K21.77460055
17WNK11.62136665
18ITK1.50892447
19FES1.46556164
20MET1.44755151
21STK41.29233659
22MAP4K11.27884510
23TAOK31.26028205
24PINK11.22656084
25GRK11.21755581
26FLT31.21196346
27PTK2B1.19016115
28FGFR21.15908352
29MAP3K111.14432757
30TIE11.11755609
31RIPK11.11234493
32SYK1.10125642
33PHKG21.08763114
34PHKG11.08763114
35BTK0.99857500
36BRAF0.96425857
37CHUK0.96244534
38IKBKB0.94575223
39KDR0.91889893
40CDK190.89045464
41LRRK20.84934361
42CAMKK20.83353799
43LYN0.82951648
44RIPK40.81314220
45ADRBK10.80552065
46MAP3K130.79700403
47PRKCI0.78510509
48DAPK10.76828680
49CAMKK10.75346416
50PIK3CA0.74557684
51ABL20.73846972
52HIPK20.72479992
53TBK10.70925518
54TTK0.69800732
55MAP2K20.69718478
56CCNB10.67905577
57PRKCE0.66254251
58PLK30.65311570
59HCK0.65031932
60CSF1R0.64322718
61PRKD20.63777931
62OXSR10.61995880
63ACVR1B0.58062397
64VRK10.54725890
65YES10.54537741
66CLK10.50167743
67MAP3K80.50071717
68IKBKE0.49591475
69CDK90.48624945
70LCK0.46834703
71MAPK130.46553891
72RPS6KA60.46330129
73DAPK30.45003049
74STK30.43762961
75MARK20.43715412
76ABL10.43424437
77TYRO30.42322821
78PRKACA0.42053997
79TXK0.41712763
80CDK40.39358995
81MAP3K30.39023065
82INSRR0.38362624
83PRKCA0.38268017
84CSK0.38089562
85GRK70.37476981
86RPS6KC10.35930984
87RPS6KL10.35930984
88PRKCQ0.33663582
89NLK0.33179715
90SGK30.32852091
91MAPK110.31790818
92PDK10.29279284
93PRKACG0.28634116
94SGK20.28505015
95ATM0.28310352
96BRSK20.28002637
97SGK10.27669935
98AKT30.27368448
99PRKAA10.25874028
100CSNK1G10.25731810

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.77789347
2Allograft rejection_Homo sapiens_hsa053304.65980088
3Autoimmune thyroid disease_Homo sapiens_hsa053204.45490889
4Graft-versus-host disease_Homo sapiens_hsa053324.35155835
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.94383380
6Type I diabetes mellitus_Homo sapiens_hsa049403.71845759
7SNARE interactions in vesicular transport_Homo sapiens_hsa041303.13858616
8Staphylococcus aureus infection_Homo sapiens_hsa051502.67877484
9Antigen processing and presentation_Homo sapiens_hsa046122.50671937
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46060333
11Viral myocarditis_Homo sapiens_hsa054162.44395981
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.39872499
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32867593
14Leishmaniasis_Homo sapiens_hsa051402.04519170
15Systemic lupus erythematosus_Homo sapiens_hsa053221.71009231
16Rheumatoid arthritis_Homo sapiens_hsa053231.67926224
17Nitrogen metabolism_Homo sapiens_hsa009101.64759404
18Caffeine metabolism_Homo sapiens_hsa002321.45207810
19Linoleic acid metabolism_Homo sapiens_hsa005911.36565995
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.34737479
21Hematopoietic cell lineage_Homo sapiens_hsa046401.33426973
22Proteasome_Homo sapiens_hsa030501.31897044
23Selenocompound metabolism_Homo sapiens_hsa004501.30180384
24Peroxisome_Homo sapiens_hsa041461.12006563
25Toxoplasmosis_Homo sapiens_hsa051451.09559215
26Regulation of autophagy_Homo sapiens_hsa041401.08507265
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04839034
28RNA degradation_Homo sapiens_hsa030181.00352021
29Tuberculosis_Homo sapiens_hsa051520.98165527
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95080729
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92322979
32Primary immunodeficiency_Homo sapiens_hsa053400.92221018
33Retinol metabolism_Homo sapiens_hsa008300.86651998
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.82787317
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81279860
36p53 signaling pathway_Homo sapiens_hsa041150.75480672
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73744090
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73534983
39Arachidonic acid metabolism_Homo sapiens_hsa005900.73517749
40Ether lipid metabolism_Homo sapiens_hsa005650.63904823
41Influenza A_Homo sapiens_hsa051640.62483248
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62339234
43Fat digestion and absorption_Homo sapiens_hsa049750.60857453
44Phototransduction_Homo sapiens_hsa047440.59688884
45Herpes simplex infection_Homo sapiens_hsa051680.58948845
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57704253
47Dorso-ventral axis formation_Homo sapiens_hsa043200.56985610
48Phagosome_Homo sapiens_hsa041450.53359513
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47308189
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45300157
51African trypanosomiasis_Homo sapiens_hsa051430.44778280
52B cell receptor signaling pathway_Homo sapiens_hsa046620.43287466
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.43055211
54Salivary secretion_Homo sapiens_hsa049700.42192341
55Legionellosis_Homo sapiens_hsa051340.42147948
56Base excision repair_Homo sapiens_hsa034100.41491644
57Long-term depression_Homo sapiens_hsa047300.41191355
58Pertussis_Homo sapiens_hsa051330.39595457
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38753794
60Pyrimidine metabolism_Homo sapiens_hsa002400.36550289
61Platelet activation_Homo sapiens_hsa046110.36459337
62Oxidative phosphorylation_Homo sapiens_hsa001900.34592290
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33583920
64Glutamatergic synapse_Homo sapiens_hsa047240.28750870
65Fatty acid degradation_Homo sapiens_hsa000710.27234255
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26845667
67Parkinsons disease_Homo sapiens_hsa050120.26831471
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26627042
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25911404
70Olfactory transduction_Homo sapiens_hsa047400.25515000
71Arginine and proline metabolism_Homo sapiens_hsa003300.23880690
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23808347
73Collecting duct acid secretion_Homo sapiens_hsa049660.22595912
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21485396
75Serotonergic synapse_Homo sapiens_hsa047260.20844450
76Sulfur metabolism_Homo sapiens_hsa009200.20492760
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.20294436
78Ovarian steroidogenesis_Homo sapiens_hsa049130.20044395
79Alzheimers disease_Homo sapiens_hsa050100.19356049
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19114407
81Oxytocin signaling pathway_Homo sapiens_hsa049210.18684622
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.17853006
83Alcoholism_Homo sapiens_hsa050340.17387445
84Tryptophan metabolism_Homo sapiens_hsa003800.16967798
85Insulin secretion_Homo sapiens_hsa049110.16286027
86Pancreatic secretion_Homo sapiens_hsa049720.16127314
87Purine metabolism_Homo sapiens_hsa002300.14735254
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14601966
89Morphine addiction_Homo sapiens_hsa050320.14046743
90Histidine metabolism_Homo sapiens_hsa003400.13272604
91Renal cell carcinoma_Homo sapiens_hsa052110.10834180
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09367473
93Malaria_Homo sapiens_hsa051440.08283318
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.07823725
95Acute myeloid leukemia_Homo sapiens_hsa052210.07672730
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.07208848
97T cell receptor signaling pathway_Homo sapiens_hsa046600.07003658
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.06371160
99Insulin resistance_Homo sapiens_hsa049310.06241823
100Chemical carcinogenesis_Homo sapiens_hsa052040.05205345

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