RPS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.26064670
2* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.69726735
3DNA deamination (GO:0045006)6.68706301
4transcription from mitochondrial promoter (GO:0006390)6.66974573
5* protein localization to endoplasmic reticulum (GO:0070972)6.60750065
6replication fork processing (GO:0031297)6.33480031
7embryonic process involved in female pregnancy (GO:0060136)6.09329783
8proline metabolic process (GO:0006560)6.04220710
9ribosomal large subunit biogenesis (GO:0042273)5.78509115
10* protein complex disassembly (GO:0043241)5.71864625
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.53318292
12* macromolecular complex disassembly (GO:0032984)5.37170971
13formation of translation preinitiation complex (GO:0001731)5.35797708
14positive regulation of protein homooligomerization (GO:0032464)5.19237848
15telomere maintenance via semi-conservative replication (GO:0032201)4.98102717
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.95135748
17somatic hypermutation of immunoglobulin genes (GO:0016446)4.95135748
18* protein targeting to membrane (GO:0006612)4.93065636
19* translation (GO:0006412)4.89732561
20viral mRNA export from host cell nucleus (GO:0046784)4.85097471
21regulation of integrin activation (GO:0033623)4.77858209
22establishment of apical/basal cell polarity (GO:0035089)4.76520571
23oxidative demethylation (GO:0070989)4.73900193
24* nuclear-transcribed mRNA catabolic process (GO:0000956)4.68971985
25mitochondrial DNA metabolic process (GO:0032042)4.62505307
26mitotic G1 DNA damage checkpoint (GO:0031571)4.47605340
27* mRNA catabolic process (GO:0006402)4.46832650
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.44525990
29DNA strand elongation involved in DNA replication (GO:0006271)4.39276910
30DNA strand renaturation (GO:0000733)4.37482041
31nucleotide-excision repair, DNA gap filling (GO:0006297)4.34394000
32regulation of protein homooligomerization (GO:0032462)4.32539177
33poly(A)+ mRNA export from nucleus (GO:0016973)4.21664171
34DNA strand elongation (GO:0022616)4.15424096
35cellular component biogenesis (GO:0044085)4.13858335
36* RNA catabolic process (GO:0006401)4.13453233
37* viral transcription (GO:0019083)4.13212047
38base-excision repair (GO:0006284)4.13053404
39telomere maintenance via recombination (GO:0000722)4.11859932
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.10380848
41chaperone-mediated protein transport (GO:0072321)4.05782249
42ATP synthesis coupled proton transport (GO:0015986)4.01380708
43energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01380708
44establishment or maintenance of monopolar cell polarity (GO:0061339)4.00780536
45establishment of monopolar cell polarity (GO:0061162)4.00780536
46mRNA cleavage (GO:0006379)3.98583663
47G1 DNA damage checkpoint (GO:0044783)3.95375932
48* translational termination (GO:0006415)3.93419112
49ribosomal small subunit assembly (GO:0000028)3.90046824
50mitotic G1/S transition checkpoint (GO:0044819)3.89450038
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.85667132
52negative regulation of cell cycle arrest (GO:0071157)3.78105321
53termination of RNA polymerase II transcription (GO:0006369)3.72871238
54* translational initiation (GO:0006413)3.72727213
55DNA integration (GO:0015074)3.67009722
56negative regulation of RNA splicing (GO:0033119)3.66263518
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.65754486
58DNA topological change (GO:0006265)3.63892135
59* translational elongation (GO:0006414)3.63541364
60regulation of mitochondrial translation (GO:0070129)3.63003419
61dosage compensation (GO:0007549)3.62494523
62negative regulation of mRNA processing (GO:0050686)3.60819414
63mitotic recombination (GO:0006312)3.59651053
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.58007503
65rRNA metabolic process (GO:0016072)3.56822366
66telomere maintenance via telomere lengthening (GO:0010833)3.55980859
67regulation of double-strand break repair via homologous recombination (GO:0010569)3.54677857
68meiotic chromosome segregation (GO:0045132)3.54349621
69negative regulation of JAK-STAT cascade (GO:0046426)3.54224676
70mitochondrial RNA metabolic process (GO:0000959)3.53492965
71spliceosomal tri-snRNP complex assembly (GO:0000244)3.52207902
72double-strand break repair via nonhomologous end joining (GO:0006303)3.51766558
73non-recombinational repair (GO:0000726)3.51766558
74cellular response to zinc ion (GO:0071294)3.51504535
75* establishment of protein localization to membrane (GO:0090150)3.48684394
76protein targeting to mitochondrion (GO:0006626)3.47811542
77kinetochore assembly (GO:0051382)3.46443616
78establishment of integrated proviral latency (GO:0075713)3.44055993
79ribosomal small subunit biogenesis (GO:0042274)3.41694591
80base-excision repair, AP site formation (GO:0006285)3.40345513
81* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37661922
82guanosine-containing compound biosynthetic process (GO:1901070)3.37619684
83regulation of sister chromatid cohesion (GO:0007063)3.34428004
84DNA ligation (GO:0006266)3.34229416
85DNA unwinding involved in DNA replication (GO:0006268)3.33688492
86embryonic placenta development (GO:0001892)3.32315207
87DNA double-strand break processing (GO:0000729)3.32176926
88maturation of 5.8S rRNA (GO:0000460)3.31320791
89* protein targeting (GO:0006605)3.29651556
90positive regulation of mitotic sister chromatid separation (GO:1901970)3.28939762
91positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28939762
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28939762
93maturation of SSU-rRNA (GO:0030490)3.28625093
94proteasome assembly (GO:0043248)3.28249450
95pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.26325815
96UTP biosynthetic process (GO:0006228)3.25096974
97rRNA modification (GO:0000154)3.24907669
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24814035
99nucleobase-containing small molecule interconversion (GO:0015949)3.23875334
100establishment of protein localization to mitochondrion (GO:0072655)3.23224413
101positive regulation of developmental pigmentation (GO:0048087)3.22773689
102negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.20143742
103oxidative phosphorylation (GO:0006119)3.18227272
104pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.17954869
105positive regulation by host of viral transcription (GO:0043923)3.17306228
106kinetochore organization (GO:0051383)3.14759126
107* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14101057
108positive regulation of protein oligomerization (GO:0032461)3.13319779
109* establishment of protein localization to organelle (GO:0072594)3.12150084
110respiratory electron transport chain (GO:0022904)3.12012709
111* viral life cycle (GO:0019058)3.10426694
112transcription elongation from RNA polymerase III promoter (GO:0006385)3.10145241
113termination of RNA polymerase III transcription (GO:0006386)3.10145241
114ncRNA 3-end processing (GO:0043628)3.08677705
115spliceosomal snRNP assembly (GO:0000387)3.08635518
116mitotic nuclear envelope reassembly (GO:0007084)3.08540185
117nuclear envelope reassembly (GO:0031468)3.08540185
118trophectodermal cell differentiation (GO:0001829)3.07976213
119regulation of double-strand break repair (GO:2000779)3.07418586
120pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.05841939
121* protein targeting to ER (GO:0045047)3.05311465
122protein localization to mitochondrion (GO:0070585)3.04784084
123regulation of DNA damage checkpoint (GO:2000001)3.04725425
124* cotranslational protein targeting to membrane (GO:0006613)3.04050564
125DNA replication initiation (GO:0006270)3.03012807
126electron transport chain (GO:0022900)3.02922670
127negative regulation of ligase activity (GO:0051352)3.02149451
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02149451
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01299282
130GTP biosynthetic process (GO:0006183)3.01295753
131cellular response to ATP (GO:0071318)3.00907970
132pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.00574957
133protein maturation by protein folding (GO:0022417)2.99934277
134mitotic chromosome condensation (GO:0007076)2.98040290
135nodal signaling pathway (GO:0038092)2.97753644
136regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97502177
137* cellular protein complex disassembly (GO:0043624)2.97210670
138histone H4-K12 acetylation (GO:0043983)2.97076691
139transcription-coupled nucleotide-excision repair (GO:0006283)2.96952031
140positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96720869
141GDP-mannose metabolic process (GO:0019673)2.95979758
142regulation of posttranscriptional gene silencing (GO:0060147)2.95960009
143regulation of gene silencing by miRNA (GO:0060964)2.95960009
144regulation of gene silencing by RNA (GO:0060966)2.95960009
145ribonucleoprotein complex biogenesis (GO:0022613)2.95415848
146rRNA processing (GO:0006364)2.95316573
147face development (GO:0060324)2.94923728
148establishment of viral latency (GO:0019043)2.94424507
149regulation of RNA export from nucleus (GO:0046831)2.93006713
150UTP metabolic process (GO:0046051)2.92781919
151inner mitochondrial membrane organization (GO:0007007)2.91801920
152ribosome biogenesis (GO:0042254)2.91713325
153positive regulation of chromosome segregation (GO:0051984)2.91132480
154pyrimidine nucleotide catabolic process (GO:0006244)2.90073690
155positive regulation of DNA repair (GO:0045739)2.89800362
156negative regulation of mRNA metabolic process (GO:1903312)2.89418385
157CTP biosynthetic process (GO:0006241)2.87908429
158CTP metabolic process (GO:0046036)2.87908429
159pseudouridine synthesis (GO:0001522)2.87496461
160pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.83044269
161ribosome assembly (GO:0042255)2.72866710
162mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.72406753
163DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70823203
164rRNA transcription (GO:0009303)2.69998358
165deoxyribonucleotide catabolic process (GO:0009264)2.69787711
166* protein localization to membrane (GO:0072657)2.69669468
167deoxyribose phosphate catabolic process (GO:0046386)2.69587224
168signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69419265
169signal transduction involved in DNA damage checkpoint (GO:0072422)2.69419265
170intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.69380893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.89548950
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.84562027
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35530352
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90452452
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78638945
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.69728330
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64121889
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.51749026
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41610572
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38395940
11VDR_21846776_ChIP-Seq_THP-1_Human2.37016766
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.27435860
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.26679174
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.26679174
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.26679174
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20436723
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19198487
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17715945
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13375950
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06482981
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02087095
22MYC_22102868_ChIP-Seq_BL_Human2.00137207
23* ETS1_20019798_ChIP-Seq_JURKAT_Human1.99138262
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94771794
25* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.92505512
26KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.90584751
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85160338
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83417044
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82923891
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77551107
31* XRN2_22483619_ChIP-Seq_HELA_Human1.76977994
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76208337
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74421045
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72022356
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70919341
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69393208
37SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.68876634
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.66554555
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66419176
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64643329
41DCP1A_22483619_ChIP-Seq_HELA_Human1.64044348
42* EST1_17652178_ChIP-ChIP_JURKAT_Human1.62667848
43TTF2_22483619_ChIP-Seq_HELA_Human1.60027909
44GABP_19822575_ChIP-Seq_HepG2_Human1.59131406
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.58775919
46* GABP_17652178_ChIP-ChIP_JURKAT_Human1.55670960
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54527647
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52221968
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50348760
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49654148
51NANOG_21062744_ChIP-ChIP_HESCs_Human1.48776188
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47269743
53* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46916543
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46618589
55* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46608599
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45924968
57PU.1_20513432_ChIP-Seq_Bcells_Mouse1.44858172
58* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44598070
59POU5F1_16518401_ChIP-PET_MESCs_Mouse1.42600445
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41711267
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41636964
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41606075
63* VDR_23849224_ChIP-Seq_CD4+_Human1.40390074
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39238317
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38807784
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38181630
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36644241
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36020734
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.35759763
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34439209
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34287461
72LXR_22292898_ChIP-Seq_THP-1_Human1.34038555
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33230992
74CIITA_25753668_ChIP-Seq_RAJI_Human1.31810366
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30928067
76KDM5A_27292631_Chip-Seq_BREAST_Human1.29896947
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29088599
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24782723
79* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24037497
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23008236
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22339165
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21867864
83ZNF263_19887448_ChIP-Seq_K562_Human1.17536549
84ELK1_19687146_ChIP-ChIP_HELA_Human1.16685744
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16341774
86* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15875223
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.15690509
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14770931
89FOXP3_21729870_ChIP-Seq_TREG_Human1.14609324
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14586428
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13788119
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13081060
93* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12001968
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.11850605
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11463286
96* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11061272
97* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10568773
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09690567
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09429304
100FOXP1_21924763_ChIP-Seq_HESCs_Human1.09148437
101* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08676843
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08503130
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07996381
104* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07864965
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06574304
106TFEB_21752829_ChIP-Seq_HELA_Human1.06547357
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04723345
108AR_21909140_ChIP-Seq_LNCAP_Human1.04658719
109RACK7_27058665_Chip-Seq_MCF-7_Human1.03957025
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03903932
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.03689331
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02810572
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02180478
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00487154
115* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00365206
116* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98314198
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98074091
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97684450
119* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96746125
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96592629
121SRF_21415370_ChIP-Seq_HL-1_Mouse0.95591474
122ETS1_21867929_ChIP-Seq_TH2_Mouse0.95090087
123* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94048113
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93614501
125P68_20966046_ChIP-Seq_HELA_Human0.93611416
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93391061
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92997114
128MAF_26560356_Chip-Seq_TH1_Human0.92416567
129CTCF_26484167_Chip-Seq_Bcells_Mouse0.92271101
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92111531
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91147406
132ELF1_20517297_ChIP-Seq_JURKAT_Human0.90183654
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89449675
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88619328
135* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88453707

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.08050974
2MP0008057_abnormal_DNA_replication5.87055738
3MP0009278_abnormal_bone_marrow3.78315342
4MP0010094_abnormal_chromosome_stability3.23780533
5MP0010030_abnormal_orbit_morphology3.23181195
6MP0004957_abnormal_blastocyst_morpholog2.98021641
7MP0005171_absent_coat_pigmentation2.92372083
8MP0002009_preneoplasia2.78259289
9MP0003693_abnormal_embryo_hatching2.69564066
10MP0003111_abnormal_nucleus_morphology2.53018665
11MP0005397_hematopoietic_system_phenotyp2.44096931
12MP0001545_abnormal_hematopoietic_system2.44096931
13MP0005451_abnormal_body_composition2.34952205
14MP0008058_abnormal_DNA_repair2.29545036
15MP0003077_abnormal_cell_cycle2.29495847
16MP0004233_abnormal_muscle_weight2.26406398
17MP0003186_abnormal_redox_activity2.25892294
18MP0003786_premature_aging2.24036624
19MP0008995_early_reproductive_senescence2.20382377
20MP0005174_abnormal_tail_pigmentation2.11271626
21MP0010352_gastrointestinal_tract_polyps2.08388128
22MP0003806_abnormal_nucleotide_metabolis2.02312908
23MP0000490_abnormal_crypts_of1.98663124
24MP0008932_abnormal_embryonic_tissue1.94126926
25MP0006292_abnormal_olfactory_placode1.92936535
26MP0006036_abnormal_mitochondrial_physio1.91843388
27MP0003890_abnormal_embryonic-extraembry1.86604747
28MP0004133_heterotaxia1.82145217
29MP0003119_abnormal_digestive_system1.69831096
30MP0006035_abnormal_mitochondrial_morpho1.69192212
31MP0003567_abnormal_fetal_cardiomyocyte1.67520834
32MP0002086_abnormal_extraembryonic_tissu1.65756032
33MP0001293_anophthalmia1.65426109
34MP0001697_abnormal_embryo_size1.65280385
35MP0002396_abnormal_hematopoietic_system1.60217050
36MP0005075_abnormal_melanosome_morpholog1.58188767
37MP0005076_abnormal_cell_differentiation1.57825929
38MP0002163_abnormal_gland_morphology1.56126945
39MP0003123_paternal_imprinting1.55984922
40MP0002084_abnormal_developmental_patter1.55813513
41MP0003283_abnormal_digestive_organ1.55096457
42MP0008877_abnormal_DNA_methylation1.55021486
43MP0000350_abnormal_cell_proliferation1.53772089
44MP0002249_abnormal_larynx_morphology1.52509252
45MP0003453_abnormal_keratinocyte_physiol1.50114182
46MP0004197_abnormal_fetal_growth/weight/1.49492677
47MP0002085_abnormal_embryonic_tissue1.47413402
48MP0003315_abnormal_perineum_morphology1.47244530
49MP0001730_embryonic_growth_arrest1.45958287
50MP0002282_abnormal_trachea_morphology1.44824711
51MP0000358_abnormal_cell_content/1.41147147
52MP0002653_abnormal_ependyma_morphology1.39045646
53MP0001672_abnormal_embryogenesis/_devel1.38802799
54MP0005380_embryogenesis_phenotype1.38802799
55MP0000537_abnormal_urethra_morphology1.38157778
56MP0001661_extended_life_span1.34804027
57MP0000678_abnormal_parathyroid_gland1.34479831
58MP0002019_abnormal_tumor_incidence1.34363607
59MP0006072_abnormal_retinal_apoptosis1.33639047
60MP0004185_abnormal_adipocyte_glucose1.30866110
61MP0002210_abnormal_sex_determination1.28475363
62MP0000685_abnormal_immune_system1.28256400
63MP0000372_irregular_coat_pigmentation1.25115632
64MP0009333_abnormal_splenocyte_physiolog1.25001971
65MP0002080_prenatal_lethality1.21934471
66MP0000371_diluted_coat_color1.17327691
67MP0008007_abnormal_cellular_replicative1.16354180
68MP0000015_abnormal_ear_pigmentation1.16317731
69MP0000470_abnormal_stomach_morphology1.15481703
70MP0000566_synostosis1.14959862
71MP0003984_embryonic_growth_retardation1.12707120
72MP0003763_abnormal_thymus_physiology1.10946669
73MP0000313_abnormal_cell_death1.09436017
74MP0001873_stomach_inflammation1.09151488
75MP0002088_abnormal_embryonic_growth/wei1.08468578
76MP0002111_abnormal_tail_morphology1.08290209
77MP0002938_white_spotting1.06690372
78MP0002796_impaired_skin_barrier1.05574431
79MP0008260_abnormal_autophagy1.05417754
80MP0001881_abnormal_mammary_gland1.05044863
81MP0010307_abnormal_tumor_latency1.04706289
82MP0009672_abnormal_birth_weight1.02558710
83MP0002160_abnormal_reproductive_system1.02379744
84MP0002166_altered_tumor_susceptibility1.01468839
85MP0002405_respiratory_system_inflammati1.01143296
86MP0001346_abnormal_lacrimal_gland0.98321643
87MP0000579_abnormal_nail_morphology0.97888713
88MP0005501_abnormal_skin_physiology0.97200850
89MP0009697_abnormal_copulation0.95865605
90MP0001929_abnormal_gametogenesis0.94940563
91MP0000689_abnormal_spleen_morphology0.93875356
92MP0003828_pulmonary_edema0.93235762
93MP0002932_abnormal_joint_morphology0.92214150
94MP0000750_abnormal_muscle_regeneration0.89518010
95MP0004858_abnormal_nervous_system0.89314673
96MP0003172_abnormal_lysosome_physiology0.88456581
97MP0004264_abnormal_extraembryonic_tissu0.87804095
98MP0003718_maternal_effect0.87798484
99MP0002075_abnormal_coat/hair_pigmentati0.86806327
100MP0008789_abnormal_olfactory_epithelium0.86173280
101MP0000762_abnormal_tongue_morphology0.86147872
102MP0000653_abnormal_sex_gland0.85884728
103MP0002060_abnormal_skin_morphology0.85755724
104MP0009053_abnormal_anal_canal0.84025804
105MP0002398_abnormal_bone_marrow0.83552426
106MP0002006_tumorigenesis0.83458905
107MP0005023_abnormal_wound_healing0.82834521
108MP0001853_heart_inflammation0.82698989
109MP0003941_abnormal_skin_development0.82241188
110MP0000462_abnormal_digestive_system0.81649390
111MP0001764_abnormal_homeostasis0.81520788
112MP0000703_abnormal_thymus_morphology0.81288367
113MP0001340_abnormal_eyelid_morphology0.80343977
114MP0000477_abnormal_intestine_morphology0.79417289
115MP0002722_abnormal_immune_system0.79398944
116MP0002269_muscular_atrophy0.77975567
117MP0005408_hypopigmentation0.76758812
118MP0000049_abnormal_middle_ear0.75144017
119MP0002114_abnormal_axial_skeleton0.74374432
120MP0003656_abnormal_erythrocyte_physiolo0.73885816
121MP0001186_pigmentation_phenotype0.73835206
122MP0001145_abnormal_male_reproductive0.73416663
123MP0005058_abnormal_lysosome_morphology0.72226009
124MP0004808_abnormal_hematopoietic_stem0.71916990
125MP0003935_abnormal_craniofacial_develop0.71875919
126MP0003566_abnormal_cell_adhesion0.71209848
127MP0002132_abnormal_respiratory_system0.70442734
128MP0010155_abnormal_intestine_physiology0.69606912
129MP0010234_abnormal_vibrissa_follicle0.68836928
130MP0000639_abnormal_adrenal_gland0.67748734
131MP0005266_abnormal_metabolism0.67401065
132MP0002697_abnormal_eye_size0.66161047
133MP0005384_cellular_phenotype0.66144970
134MP0005367_renal/urinary_system_phenotyp0.65908599
135MP0000516_abnormal_urinary_system0.65908599
136MP0003755_abnormal_palate_morphology0.65855666
137MP0005499_abnormal_olfactory_system0.65289252
138MP0005394_taste/olfaction_phenotype0.65289252
139MP0000432_abnormal_head_morphology0.64243365
140MP0001727_abnormal_embryo_implantation0.62411637
141MP0002095_abnormal_skin_pigmentation0.62115552
142MP0003699_abnormal_female_reproductive0.61929521
143MP0001119_abnormal_female_reproductive0.60166204
144MP0003943_abnormal_hepatobiliary_system0.59806263
145MP0000627_abnormal_mammary_gland0.59675204
146MP0009931_abnormal_skin_appearance0.59522064
147MP0010771_integument_phenotype0.57529287
148MP0002429_abnormal_blood_cell0.57179033
149MP0002161_abnormal_fertility/fecundity0.55963876

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.85654424
2Pustule (HP:0200039)4.71702253
3Poikiloderma (HP:0001029)4.64315399
4Concave nail (HP:0001598)4.62329812
5Facial hemangioma (HP:0000329)4.36650537
6Rectovaginal fistula (HP:0000143)4.29900360
7Rectal fistula (HP:0100590)4.29900360
8Abnormal mitochondria in muscle tissue (HP:0008316)4.29792347
9Microvesicular hepatic steatosis (HP:0001414)4.25484297
10Acute necrotizing encephalopathy (HP:0006965)4.21454939
11Annular pancreas (HP:0001734)4.17649949
12Mitochondrial inheritance (HP:0001427)4.08035246
13Increased IgM level (HP:0003496)3.96799135
14Hepatocellular necrosis (HP:0001404)3.94656218
15Abnormal hemoglobin (HP:0011902)3.91180897
16Acute encephalopathy (HP:0006846)3.90660972
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.87628091
18Increased hepatocellular lipid droplets (HP:0006565)3.86644406
19Intestinal fistula (HP:0100819)3.82578081
20Increased CSF lactate (HP:0002490)3.77058412
21Vaginal fistula (HP:0004320)3.76741775
22Alopecia of scalp (HP:0002293)3.67858829
23Ulnar bowing (HP:0003031)3.64094124
24Absent thumb (HP:0009777)3.60211063
25Abnormality of cells of the erythroid lineage (HP:0012130)3.57355968
26Tongue fasciculations (HP:0001308)3.54957320
27Hepatic necrosis (HP:0002605)3.54917218
28Increased intramyocellular lipid droplets (HP:0012240)3.54840419
29Lipid accumulation in hepatocytes (HP:0006561)3.42146873
30Selective tooth agenesis (HP:0001592)3.37611564
31Hypochromic microcytic anemia (HP:0004840)3.36077771
32Abnormal number of erythroid precursors (HP:0012131)3.34947388
33Aplasia/hypoplasia of the humerus (HP:0006507)3.33906521
34Vertebral hypoplasia (HP:0008417)3.33464804
35Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.33464804
36Absent radius (HP:0003974)3.28763680
37Short humerus (HP:0005792)3.27530883
38Basal cell carcinoma (HP:0002671)3.25688799
39Squamous cell carcinoma (HP:0002860)3.24873365
40Muscle fibrillation (HP:0010546)3.21679542
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.20464311
42Intestinal atresia (HP:0011100)3.20225419
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16764978
44Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16764978
45Respiratory difficulties (HP:0002880)3.16287410
46Progressive macrocephaly (HP:0004481)3.13634605
47Patellar aplasia (HP:0006443)3.13589047
48Abnormality of reticulocytes (HP:0004312)3.13335972
49Orthostatic hypotension (HP:0001278)3.11696137
50Progressive muscle weakness (HP:0003323)3.11632578
51Renal Fanconi syndrome (HP:0001994)3.09633544
52Increased muscle lipid content (HP:0009058)3.09555144
53Reticulocytopenia (HP:0001896)3.09456482
54Absent forearm bone (HP:0003953)3.06238107
55Aplasia involving forearm bones (HP:0009822)3.06238107
56Turricephaly (HP:0000262)3.02726618
57Increased serum lactate (HP:0002151)3.00849430
58Premature graying of hair (HP:0002216)2.95667218
59Cerebral edema (HP:0002181)2.94595032
60Aplasia/Hypoplasia of the patella (HP:0006498)2.90553283
61Abnormality of male internal genitalia (HP:0000022)2.89520693
62Exercise intolerance (HP:0003546)2.86369802
63Lactic acidosis (HP:0003128)2.82148346
64Coronal craniosynostosis (HP:0004440)2.79733944
65Male infertility (HP:0003251)2.78431887
66Albinism (HP:0001022)2.70462665
67Broad alveolar ridges (HP:0000187)2.68574558
68Congenital hip dislocation (HP:0001374)2.68221543
69Trismus (HP:0000211)2.67620166
70Premature skin wrinkling (HP:0100678)2.64092481
71Thrombocytosis (HP:0001894)2.61598748
72Abnormality of glycolysis (HP:0004366)2.60824192
73Rough bone trabeculation (HP:0100670)2.59782456
74Testicular atrophy (HP:0000029)2.59591861
75Anteriorly placed anus (HP:0001545)2.58667413
76Hypoplasia of the radius (HP:0002984)2.57013493
77Hypochromic anemia (HP:0001931)2.56995950
78Aplastic anemia (HP:0001915)2.55537312
79Short chin (HP:0000331)2.54873122
80Type I transferrin isoform profile (HP:0003642)2.54675034
81Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54502014
82Hypotrichosis (HP:0001006)2.52443794
83Multiple enchondromatosis (HP:0005701)2.52306622
84Volvulus (HP:0002580)2.52246751
85Ragged-red muscle fibers (HP:0003200)2.48759743
86Alacrima (HP:0000522)2.48119662
87Abnormality of the aortic arch (HP:0012303)2.47742114
88Abnormal number of incisors (HP:0011064)2.44096314
89Acute lymphatic leukemia (HP:0006721)2.44084931
90Bifid uvula (HP:0000193)2.41009951
91Diaphragmatic weakness (HP:0009113)2.40857183
92IgA deficiency (HP:0002720)2.39516410
93Increased serum pyruvate (HP:0003542)2.38741324
94Respiratory failure (HP:0002878)2.37779801
95Joint stiffness (HP:0001387)2.36425734
96Muscle fiber atrophy (HP:0100295)2.35931210
97Dysautonomia (HP:0002459)2.35491301
98Broad distal phalanx of finger (HP:0009836)2.30888185
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30421565
100Chromsome breakage (HP:0040012)2.26928644
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25411632
102Hypotelorism (HP:0000601)2.24925065
103Capillary hemangiomas (HP:0005306)2.22278763
104Premature ovarian failure (HP:0008209)2.22148104
105Mucopolysacchariduria (HP:0008155)2.20300253
106Urinary glycosaminoglycan excretion (HP:0003541)2.20300253
107Exertional dyspnea (HP:0002875)2.18206311
108Large for gestational age (HP:0001520)2.17487911
109Pancreatic islet-cell hyperplasia (HP:0004510)2.16959981
110Bowing of the arm (HP:0006488)2.15362216
111Bowed forearm bones (HP:0003956)2.15362216
112Microretrognathia (HP:0000308)2.15332111
113Breast hypoplasia (HP:0003187)2.13969275
114Pancytopenia (HP:0001876)2.13273937
115Abnormality of the ileum (HP:0001549)2.11200674
116Gastrointestinal atresia (HP:0002589)2.09203581
117Cleft eyelid (HP:0000625)2.09003268
118Hamartoma (HP:0010566)2.08508309
119Oral leukoplakia (HP:0002745)2.08130534
120Horseshoe kidney (HP:0000085)2.08036393
121Abnormality of the labia minora (HP:0012880)2.07906125
122Choanal stenosis (HP:0000452)2.07773742
12311 pairs of ribs (HP:0000878)2.07672284
124Type 2 muscle fiber atrophy (HP:0003554)2.07448237
125Cholecystitis (HP:0001082)2.06677236
126Abnormal gallbladder physiology (HP:0012438)2.06677236
127Vertebral fusion (HP:0002948)2.06498652
128Birth length less than 3rd percentile (HP:0003561)2.04588540
129Growth hormone excess (HP:0000845)2.02995122
130Short thumb (HP:0009778)2.02214834
131Abnormal protein glycosylation (HP:0012346)2.01708435
132Abnormal glycosylation (HP:0012345)2.01708435
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01708435
134Abnormal protein N-linked glycosylation (HP:0012347)2.01708435
135Polycythemia (HP:0001901)2.01429371
136Abnormality of the preputium (HP:0100587)2.01006113
137Redundant skin (HP:0001582)2.00093499
138Short 5th finger (HP:0009237)2.00062393
139Facial cleft (HP:0002006)1.99276424
1403-Methylglutaconic aciduria (HP:0003535)1.96089508
141Colon cancer (HP:0003003)1.94423954
142Increased number of teeth (HP:0011069)1.93585599
143Neoplasm of the oral cavity (HP:0100649)1.93220289
144Abnormal trabecular bone morphology (HP:0100671)1.91770303
145Aplasia of the musculature (HP:0100854)1.91246571
146Decreased lacrimation (HP:0000633)1.91218105
147Hypoplasia of the ulna (HP:0003022)1.89740641
148Pallor (HP:0000980)1.89662795
149Missing ribs (HP:0000921)1.88663133
150Abnormality of the astrocytes (HP:0100707)1.88310724
151Astrocytoma (HP:0009592)1.88310724
152Emotional lability (HP:0000712)1.87627995
153Leukodystrophy (HP:0002415)1.87401316
154Cerebral aneurysm (HP:0004944)1.87332583
155Macrocytic anemia (HP:0001972)1.87242323
156Abnormality of polysaccharide metabolism (HP:0011012)1.87226031
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87226031
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87226031
159Reduced antithrombin III activity (HP:0001976)1.86956216
160Cerebral hypomyelination (HP:0006808)1.84673995
161Dysostosis multiplex (HP:0000943)1.84540993
162Seborrheic dermatitis (HP:0001051)1.84143170
163Depressed nasal ridge (HP:0000457)1.83305757
164Secondary amenorrhea (HP:0000869)1.81844658
165Sparse eyelashes (HP:0000653)1.80744098
166Abnormality of the umbilical cord (HP:0010881)1.80428963
167Abnormality of the anterior horn cell (HP:0006802)1.79156765
168Degeneration of anterior horn cells (HP:0002398)1.79156765
169Hypergonadotropic hypogonadism (HP:0000815)1.76274149
170Progressive external ophthalmoplegia (HP:0000590)1.76107856
171Triphalangeal thumb (HP:0001199)1.74194553
172Partial duplication of thumb phalanx (HP:0009944)1.68424603
173Myelodysplasia (HP:0002863)1.68307927
174Sensory axonal neuropathy (HP:0003390)1.68149529
175Duplication of thumb phalanx (HP:0009942)1.63872011
176Thick lower lip vermilion (HP:0000179)1.61071204
177Death in infancy (HP:0001522)1.60241000
178Truncus arteriosus (HP:0001660)1.58364835
179Lethargy (HP:0001254)1.57786590
180Abnormalities of placenta or umbilical cord (HP:0001194)1.55650278
181Hypertensive crisis (HP:0100735)1.55078411
182Meckel diverticulum (HP:0002245)1.54682724
183Partial duplication of the phalanx of hand (HP:0009999)1.54633832
184Abnormality of DNA repair (HP:0003254)1.54369842
185Dicarboxylic aciduria (HP:0003215)1.51054304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.18789309
2VRK24.79881740
3DDR24.38551745
4MAP3K64.06152096
5MAPK154.01337171
6MAP3K113.54250364
7MATK2.90802857
8STK162.88960055
9SMG12.79794258
10PIM22.76980149
11PINK12.48837501
12PBK2.43280347
13FGR2.38809528
14TYRO32.33245646
15ARAF2.32657429
16NME12.20000905
17DAPK12.18581471
18CDK72.16443219
19CDK192.09443452
20YES12.00775569
21UHMK12.00520690
22PRKD21.92501673
23BMX1.88098359
24CSK1.87100290
25DYRK1B1.87031484
26PIM11.73663302
27BCKDK1.73551730
28WEE11.66945027
29PDGFRA1.63117528
30NME21.60518027
31CDK61.59009440
32IRAK31.56982931
33BRAF1.55947359
34DYRK31.55614630
35RPS6KB21.52320812
36BUB11.51851863
37TRPM71.48215354
38SCYL21.42921278
39ZAK1.42099850
40MAP3K101.36704686
41RPS6KC11.35387616
42RPS6KL11.35387616
43CDC71.32429321
44TAF11.25191658
45PLK11.24831914
46RPS6KA61.21952839
47CHEK21.18366164
48BRSK11.12904924
49NEK21.12382476
50PRPF4B1.06898257
51ABL21.05594129
52ATR1.04607955
53MAPK111.03079835
54MAP4K10.96622895
55MUSK0.90313167
56KDR0.89537158
57AKT30.89493200
58LATS20.85284350
59TAOK20.85208621
60PLK40.84839739
61EPHA20.84311859
62GSK3A0.83534369
63AURKB0.77717386
64PDK20.77094878
65CDC42BPA0.75785885
66SIK10.75675322
67DAPK30.74879584
68FLT30.73244795
69ERN10.72812075
70TESK10.72331609
71PRKCI0.71685103
72TLK10.71377498
73MST1R0.71363493
74RPS6KA10.71115031
75EEF2K0.70241818
76HIPK20.69488065
77CDK40.64788371
78MTOR0.64749519
79AURKA0.64615133
80BRSK20.63982311
81EIF2AK30.63182319
82RPS6KA50.62466224
83CDK120.62041524
84TSSK60.61966536
85CDK20.61490041
86MAPKAPK30.61217756
87MAP2K20.59201857
88AKT20.55977120
89* CSNK2A10.55240687
90STK100.54061068
91CHEK10.53697211
92PLK30.53387021
93CSNK2A20.53157966
94LYN0.53144126
95RAF10.50832963
96TTK0.50248084
97ACVR1B0.50109503
98NEK10.49974040
99PKN20.49713296
100CCNB10.49409962
101PHKG20.49391667
102PHKG10.49391667
103PAK40.47876737
104IRAK20.46946276
105TGFBR10.46634854
106TRIB30.46558413
107CDK90.45732171
108MAP2K30.45134110
109SRPK10.43836432
110MAP3K80.43420459
111ATM0.43322902
112LRRK20.42896256
113CDK80.42601618
114RPS6KB10.42045229
115TESK20.41176023
116PASK0.38412922
117MAPKAPK20.37967681
118DYRK20.37961404
119MAPK30.37175290
120EGFR0.37041624
121PRKAA10.36111537
122VRK10.35951958
123IKBKB0.35320722
124RPS6KA40.33962932
125IRAK40.33806545
126MAPK10.33090501
127PAK10.32667888
128MST40.32230247
129ALK0.32135185
130PTK60.31949886
131PAK20.31924480
132CLK10.30751549
133MAPK40.30658409
134CDK10.30390507
135ERBB30.30378429
136CSNK1G10.29925062
137ILK0.29121599
138STK30.29077812
139STK40.29044700
140LMTK20.28340751
141CDK11A0.27937088
142PRKD30.27493223
143LCK0.27017091
144MAP3K120.26863903
145EIF2AK10.25637998

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.28350089
2DNA replication_Homo sapiens_hsa030304.96009532
3Base excision repair_Homo sapiens_hsa034104.54950793
4* Ribosome_Homo sapiens_hsa030103.67912463
5Fatty acid biosynthesis_Homo sapiens_hsa000612.99379333
6Spliceosome_Homo sapiens_hsa030402.91797651
7Nucleotide excision repair_Homo sapiens_hsa034202.89954900
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87987989
9Oxidative phosphorylation_Homo sapiens_hsa001902.81812785
10Parkinsons disease_Homo sapiens_hsa050122.62431433
11Homologous recombination_Homo sapiens_hsa034402.59725605
12RNA transport_Homo sapiens_hsa030132.54534918
13Fanconi anemia pathway_Homo sapiens_hsa034602.00782975
14Cell cycle_Homo sapiens_hsa041101.96758901
15mRNA surveillance pathway_Homo sapiens_hsa030151.92741127
16Proteasome_Homo sapiens_hsa030501.86892593
17p53 signaling pathway_Homo sapiens_hsa041151.81154055
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74809628
19RNA polymerase_Homo sapiens_hsa030201.73752511
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64355543
21Alzheimers disease_Homo sapiens_hsa050101.62128624
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57658217
23Notch signaling pathway_Homo sapiens_hsa043301.48032010
24One carbon pool by folate_Homo sapiens_hsa006701.41606341
25Sulfur relay system_Homo sapiens_hsa041221.39477441
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38691080
27Pyrimidine metabolism_Homo sapiens_hsa002401.38408816
28Hippo signaling pathway_Homo sapiens_hsa043901.31152024
29Hedgehog signaling pathway_Homo sapiens_hsa043401.29953764
30Carbon metabolism_Homo sapiens_hsa012001.25151910
31Primary immunodeficiency_Homo sapiens_hsa053401.24597679
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22179041
33Folate biosynthesis_Homo sapiens_hsa007901.21616642
34mTOR signaling pathway_Homo sapiens_hsa041501.21398555
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17139522
36Biosynthesis of amino acids_Homo sapiens_hsa012301.13095971
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09635744
38RNA degradation_Homo sapiens_hsa030181.08769882
39Arginine and proline metabolism_Homo sapiens_hsa003301.07570144
40Adherens junction_Homo sapiens_hsa045201.07403272
41Shigellosis_Homo sapiens_hsa051311.06359421
42TGF-beta signaling pathway_Homo sapiens_hsa043501.04464390
43Fatty acid elongation_Homo sapiens_hsa000621.01995007
44Bladder cancer_Homo sapiens_hsa052191.00405475
45Pyruvate metabolism_Homo sapiens_hsa006200.95273085
46Basal cell carcinoma_Homo sapiens_hsa052170.95180050
47Circadian rhythm_Homo sapiens_hsa047100.93713776
48Basal transcription factors_Homo sapiens_hsa030220.92951138
49Protein export_Homo sapiens_hsa030600.91233699
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85336484
51Non-homologous end-joining_Homo sapiens_hsa034500.82730751
52Herpes simplex infection_Homo sapiens_hsa051680.81616341
53Epstein-Barr virus infection_Homo sapiens_hsa051690.80461820
54Cardiac muscle contraction_Homo sapiens_hsa042600.78416304
55Viral carcinogenesis_Homo sapiens_hsa052030.77714816
56Legionellosis_Homo sapiens_hsa051340.76410657
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74400775
58Oocyte meiosis_Homo sapiens_hsa041140.74079503
59Wnt signaling pathway_Homo sapiens_hsa043100.73054370
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72545301
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70997797
62Small cell lung cancer_Homo sapiens_hsa052220.70889752
63Vitamin B6 metabolism_Homo sapiens_hsa007500.70417709
64Colorectal cancer_Homo sapiens_hsa052100.69377080
65MicroRNAs in cancer_Homo sapiens_hsa052060.68899801
66Thyroid cancer_Homo sapiens_hsa052160.67462806
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66476472
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66265632
69Metabolic pathways_Homo sapiens_hsa011000.64416033
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64050443
71Fructose and mannose metabolism_Homo sapiens_hsa000510.63771314
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62633612
73Chronic myeloid leukemia_Homo sapiens_hsa052200.60975732
74Acute myeloid leukemia_Homo sapiens_hsa052210.60794924
75Viral myocarditis_Homo sapiens_hsa054160.58342784
76HTLV-I infection_Homo sapiens_hsa051660.57705405
77Glutathione metabolism_Homo sapiens_hsa004800.57117820
78VEGF signaling pathway_Homo sapiens_hsa043700.57051285
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55866170
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54030559
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53716950
82Lysine degradation_Homo sapiens_hsa003100.50490616
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49973093
84Galactose metabolism_Homo sapiens_hsa000520.49779749
85Sulfur metabolism_Homo sapiens_hsa009200.47001144
86Systemic lupus erythematosus_Homo sapiens_hsa053220.45557594
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44667947
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43763015
89Hepatitis B_Homo sapiens_hsa051610.40537192
90Measles_Homo sapiens_hsa051620.39265241
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.37484808
92Tight junction_Homo sapiens_hsa045300.36425401
93Purine metabolism_Homo sapiens_hsa002300.36342287
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36260940
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35619577
96N-Glycan biosynthesis_Homo sapiens_hsa005100.35321645
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.34941895
98Antigen processing and presentation_Homo sapiens_hsa046120.33779263
99Alcoholism_Homo sapiens_hsa050340.33450986
100Phenylalanine metabolism_Homo sapiens_hsa003600.32151340
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31105862
102Apoptosis_Homo sapiens_hsa042100.29911286
103Fatty acid metabolism_Homo sapiens_hsa012120.29003227
104Tyrosine metabolism_Homo sapiens_hsa003500.28744855
105Pathways in cancer_Homo sapiens_hsa052000.28340871
106Selenocompound metabolism_Homo sapiens_hsa004500.28006600
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.26714349
108B cell receptor signaling pathway_Homo sapiens_hsa046620.26546292
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.25986516
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.25659282
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25449057
112Huntingtons disease_Homo sapiens_hsa050160.24244809
113HIF-1 signaling pathway_Homo sapiens_hsa040660.23672710
114Proteoglycans in cancer_Homo sapiens_hsa052050.22759104
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21595091
116Steroid biosynthesis_Homo sapiens_hsa001000.21573082
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20655454
118Pentose phosphate pathway_Homo sapiens_hsa000300.19750300
119AMPK signaling pathway_Homo sapiens_hsa041520.19262398
120Non-small cell lung cancer_Homo sapiens_hsa052230.19014407
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18422802
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17475863
123Vitamin digestion and absorption_Homo sapiens_hsa049770.17472593
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16967964
125Prostate cancer_Homo sapiens_hsa052150.16757513
126Arginine biosynthesis_Homo sapiens_hsa002200.16371251
127Vibrio cholerae infection_Homo sapiens_hsa051100.15869473
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15727026
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15480662
130Peroxisome_Homo sapiens_hsa041460.15379980
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.14416641
132Propanoate metabolism_Homo sapiens_hsa006400.14403114
133Pancreatic cancer_Homo sapiens_hsa052120.11135538
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09110507
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06528747
136Other glycan degradation_Homo sapiens_hsa005110.04752072

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