RPS5P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic chromosome segregation (GO:0045132)6.30477475
2regulation of DNA endoreduplication (GO:0032875)6.23244274
3negative regulation of heart rate (GO:0010459)5.89914109
4replication fork processing (GO:0031297)5.81789281
5resolution of meiotic recombination intermediates (GO:0000712)5.70357545
6negative regulation of appetite (GO:0032099)5.60794883
7negative regulation of response to food (GO:0032096)5.60794883
8DNA-dependent DNA replication (GO:0006261)5.01461392
9kinetochore organization (GO:0051383)4.98539653
10UDP-N-acetylglucosamine metabolic process (GO:0006047)4.78567782
11kinetochore assembly (GO:0051382)4.72552406
12somatic hypermutation of immunoglobulin genes (GO:0016446)4.70580601
13somatic diversification of immune receptors via somatic mutation (GO:0002566)4.70580601
14negative regulation of DNA-dependent DNA replication (GO:2000104)4.62648741
15regulation of nuclear cell cycle DNA replication (GO:0033262)4.61159197
16mismatch repair (GO:0006298)4.35759318
17regulation of meiosis I (GO:0060631)4.32997241
18protein K11-linked deubiquitination (GO:0035871)4.32402835
19maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.27422793
20proteasome assembly (GO:0043248)4.09176137
21inner ear receptor stereocilium organization (GO:0060122)4.04017677
22phosphatidylethanolamine biosynthetic process (GO:0006646)4.01074568
23phosphatidylethanolamine metabolic process (GO:0046337)3.98781648
24pyrimidine dimer repair (GO:0006290)3.97783084
25auditory receptor cell stereocilium organization (GO:0060088)3.95634595
26regulation of response to food (GO:0032095)3.90876034
27inflammatory response to antigenic stimulus (GO:0002437)3.85858022
28regulation of timing of cell differentiation (GO:0048505)3.76700151
29spinal cord development (GO:0021510)3.74945631
30replicative senescence (GO:0090399)3.71147078
31ventricular cardiac muscle cell development (GO:0055015)3.66956719
32DNA ligation (GO:0006266)3.65237032
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.61888314
34DNA damage induced protein phosphorylation (GO:0006975)3.55824772
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.48756859
36DNA double-strand break processing (GO:0000729)3.48005094
37phosphate ion transport (GO:0006817)3.39672748
38aggressive behavior (GO:0002118)3.34844032
39L-fucose catabolic process (GO:0042355)3.33120359
40fucose catabolic process (GO:0019317)3.33120359
41L-fucose metabolic process (GO:0042354)3.33120359
42snRNA processing (GO:0016180)3.33109913
43presynaptic membrane assembly (GO:0097105)3.24030444
44microtubule depolymerization (GO:0007019)3.22762614
45negative regulation of astrocyte differentiation (GO:0048712)3.22627359
46spindle assembly involved in mitosis (GO:0090307)3.21294258
47regulation of development, heterochronic (GO:0040034)3.18405256
48regulation of appetite (GO:0032098)3.12483903
49somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.11035295
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.11035295
51isotype switching (GO:0045190)3.11035295
52regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.01335866
53response to pheromone (GO:0019236)2.98309748
54somite development (GO:0061053)2.97718702
55reciprocal DNA recombination (GO:0035825)2.96231595
56reciprocal meiotic recombination (GO:0007131)2.96231595
57regulation of MHC class II biosynthetic process (GO:0045346)2.95895976
58intra-S DNA damage checkpoint (GO:0031573)2.95208133
59C-terminal protein lipidation (GO:0006501)2.93370500
60establishment of protein localization to mitochondrial membrane (GO:0090151)2.92190545
61secondary metabolite biosynthetic process (GO:0044550)2.91958379
62olfactory bulb development (GO:0021772)2.91748832
63acrosome assembly (GO:0001675)2.90721393
64base-excision repair (GO:0006284)2.90404041
65monoubiquitinated protein deubiquitination (GO:0035520)2.89773467
66negative regulation of meiosis (GO:0045835)2.87715104
67dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.84961954
68synapsis (GO:0007129)2.83394943
69mitochondrial DNA replication (GO:0006264)2.82574785
70oxidative phosphorylation (GO:0006119)2.82132436
71recombinational repair (GO:0000725)2.78089310
72melanin biosynthetic process (GO:0042438)2.77752976
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.77524253
74negative regulation of translation, ncRNA-mediated (GO:0040033)2.77524253
75regulation of translation, ncRNA-mediated (GO:0045974)2.77524253
76DNA strand renaturation (GO:0000733)2.76422409
77response to X-ray (GO:0010165)2.75967513
78retinal cone cell development (GO:0046549)2.73848872
79double-strand break repair via homologous recombination (GO:0000724)2.73549071
80snRNA metabolic process (GO:0016073)2.73346852
81generation of neurons (GO:0048699)2.72681960
82regulation of helicase activity (GO:0051095)2.69598490
83epithelial cilium movement (GO:0003351)2.69597205
84negative regulation of insulin secretion (GO:0046676)2.69140117
85negative regulation of response to nutrient levels (GO:0032108)2.67456706
86negative regulation of response to extracellular stimulus (GO:0032105)2.67456706
87axonemal dynein complex assembly (GO:0070286)2.66801019
88somatic diversification of immunoglobulins (GO:0016445)2.66675078
89axoneme assembly (GO:0035082)2.64272783
90cilium organization (GO:0044782)2.64017963
91CDP-diacylglycerol biosynthetic process (GO:0016024)2.62840072
92cilium assembly (GO:0042384)2.61934733
93presynaptic membrane organization (GO:0097090)2.61055848
94spindle checkpoint (GO:0031577)2.58877007
95response to nitrosative stress (GO:0051409)2.58405152
96sister chromatid segregation (GO:0000819)2.57873253
97negative regulation of heart contraction (GO:0045822)2.56149209
98phosphatidylinositol phosphorylation (GO:0046854)2.55603836
99SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.55140538
100chromatin remodeling at centromere (GO:0031055)2.53390643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.47095401
2IGF1R_20145208_ChIP-Seq_DFB_Human3.45289887
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.44623425
4ZNF274_21170338_ChIP-Seq_K562_Hela3.40327925
5AR_21572438_ChIP-Seq_LNCaP_Human3.25716597
6GBX2_23144817_ChIP-Seq_PC3_Human3.14243217
7E2F7_22180533_ChIP-Seq_HELA_Human2.92177260
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.82571331
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77830605
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.77254871
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72374398
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69118618
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.49497387
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38863606
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38862222
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38774419
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.36045867
18VDR_22108803_ChIP-Seq_LS180_Human2.34537680
19BCAT_22108803_ChIP-Seq_LS180_Human2.18468440
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14996623
21EWS_26573619_Chip-Seq_HEK293_Human2.09482746
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04822118
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.03183520
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98154416
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97077214
26TAF15_26573619_Chip-Seq_HEK293_Human1.93380970
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88650686
28P300_19829295_ChIP-Seq_ESCs_Human1.86077491
29FUS_26573619_Chip-Seq_HEK293_Human1.85886888
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82140811
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78998187
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.75925360
33ER_23166858_ChIP-Seq_MCF-7_Human1.72271722
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.71602133
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63558158
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62026515
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58397403
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57343866
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52364300
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42751207
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39437137
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39263671
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.39263671
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39188077
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37595463
46TCF4_23295773_ChIP-Seq_U87_Human1.34965394
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33827101
48ELK1_19687146_ChIP-ChIP_HELA_Human1.32698137
49IRF1_19129219_ChIP-ChIP_H3396_Human1.31164667
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30774939
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30644424
52TCF4_22108803_ChIP-Seq_LS180_Human1.29326596
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.29154281
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26757115
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.25306801
56SMAD4_21799915_ChIP-Seq_A2780_Human1.25071325
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21949256
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21741053
59CBP_20019798_ChIP-Seq_JUKART_Human1.21741053
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21308643
61MYC_18940864_ChIP-ChIP_HL60_Human1.20683614
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19398414
63CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.17994195
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.16437155
65STAT3_23295773_ChIP-Seq_U87_Human1.15565546
66AR_25329375_ChIP-Seq_VCAP_Human1.15092161
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15024114
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14682665
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.13460950
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13005556
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.12749772
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.10786531
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10458939
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07479276
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.07281920
76NANOG_19829295_ChIP-Seq_ESCs_Human1.07189943
77SOX2_19829295_ChIP-Seq_ESCs_Human1.07189943
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07040755
79AHR_22903824_ChIP-Seq_MCF-7_Human1.05939837
80LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05199037
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04617149
82HOXB7_26014856_ChIP-Seq_BT474_Human0.97782671
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97341008
84FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96776032
85FOXA1_25329375_ChIP-Seq_VCAP_Human0.96776032
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96731810
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96629994
88SOX9_26525672_Chip-Seq_HEART_Mouse0.96523962
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.96330098
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95725877
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95263570
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94740937
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.94559270
94JUN_21703547_ChIP-Seq_K562_Human0.94477933
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93532447
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93458446
97AR_20517297_ChIP-Seq_VCAP_Human0.93328917
98TP53_22573176_ChIP-Seq_HFKS_Human0.92839618
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90934577
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90457486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.81042671
2MP0000569_abnormal_digit_pigmentation3.23496626
3MP0006292_abnormal_olfactory_placode3.12103159
4MP0003136_yellow_coat_color2.88030433
5MP0005646_abnormal_pituitary_gland2.85248022
6MP0005551_abnormal_eye_electrophysiolog2.81039632
7MP0009764_decreased_sensitivity_to2.68866599
8MP0010368_abnormal_lymphatic_system2.65171375
9MP0008877_abnormal_DNA_methylation2.62489675
10MP0000372_irregular_coat_pigmentation2.46726553
11MP0002090_abnormal_vision2.34911786
12MP0002938_white_spotting2.33532879
13MP0008872_abnormal_physiological_respon2.21373680
14MP0004742_abnormal_vestibular_system2.19598567
15MP0002102_abnormal_ear_morphology2.18609286
16MP0003646_muscle_fatigue2.14228121
17MP0003718_maternal_effect1.91276333
18MP0003787_abnormal_imprinting1.84604433
19MP0000015_abnormal_ear_pigmentation1.82420579
20MP0000631_abnormal_neuroendocrine_gland1.81796630
21MP0003195_calcinosis1.80923124
22MP0010094_abnormal_chromosome_stability1.80051575
23MP0003880_abnormal_central_pattern1.77906434
24MP0001177_atelectasis1.73168061
25MP0004484_altered_response_of1.68397111
26MP0005171_absent_coat_pigmentation1.65659862
27MP0002736_abnormal_nociception_after1.60741629
28MP0005253_abnormal_eye_physiology1.60536512
29MP0000427_abnormal_hair_cycle1.58338498
30MP0006072_abnormal_retinal_apoptosis1.56335929
31MP0000467_abnormal_esophagus_morphology1.43509896
32MP0005395_other_phenotype1.42407371
33MP0004885_abnormal_endolymph1.42105190
34MP0002234_abnormal_pharynx_morphology1.41417020
35MP0001968_abnormal_touch/_nociception1.41139666
36MP0004215_abnormal_myocardial_fiber1.39132132
37MP0005174_abnormal_tail_pigmentation1.38527731
38MP0005647_abnormal_sex_gland1.37564917
39MP0002168_other_aberrant_phenotype1.35766383
40MP0008873_increased_physiological_sensi1.34693919
41MP0003937_abnormal_limbs/digits/tail_de1.34098731
42MP0004145_abnormal_muscle_electrophysio1.29877653
43MP0000383_abnormal_hair_follicle1.25382909
44MP0002557_abnormal_social/conspecific_i1.24122490
45MP0002282_abnormal_trachea_morphology1.23909324
46MP0003936_abnormal_reproductive_system1.19851697
47MP0002095_abnormal_skin_pigmentation1.17890573
48MP0003077_abnormal_cell_cycle1.17021900
49MP0003121_genomic_imprinting1.12214423
50MP0006035_abnormal_mitochondrial_morpho1.11021515
51MP0002210_abnormal_sex_determination1.10267638
52MP0003123_paternal_imprinting1.09469213
53MP0001293_anophthalmia1.07787182
54MP0004147_increased_porphyrin_level1.07530781
55MP0009745_abnormal_behavioral_response1.05032168
56MP0000778_abnormal_nervous_system1.03057804
57MP0001324_abnormal_eye_pigmentation1.02276804
58MP0009046_muscle_twitch1.02149157
59MP0001764_abnormal_homeostasis1.02099058
60MP0005310_abnormal_salivary_gland1.00807267
61MP0001119_abnormal_female_reproductive1.00354964
62MP0008775_abnormal_heart_ventricle1.00336413
63MP0000647_abnormal_sebaceous_gland0.99271058
64MP0002254_reproductive_system_inflammat0.98247940
65MP0002233_abnormal_nose_morphology0.97330348
66MP0005367_renal/urinary_system_phenotyp0.96930890
67MP0000516_abnormal_urinary_system0.96930890
68MP0009053_abnormal_anal_canal0.94428956
69MP0000026_abnormal_inner_ear0.92947662
70MP0003698_abnormal_male_reproductive0.92765240
71MP0003011_delayed_dark_adaptation0.89597227
72MP0003045_fibrosis0.87173014
73MP0001929_abnormal_gametogenesis0.85970401
74MP0002752_abnormal_somatic_nervous0.85238029
75MP0005408_hypopigmentation0.84677259
76MP0005195_abnormal_posterior_eye0.82179669
77MP0005410_abnormal_fertilization0.81729194
78MP0003938_abnormal_ear_development0.81602142
79MP0002098_abnormal_vibrissa_morphology0.80758841
80MP0005332_abnormal_amino_acid0.79213186
81MP0005391_vision/eye_phenotype0.79189451
82MP0002067_abnormal_sensory_capabilities0.78969521
83MP0002876_abnormal_thyroid_physiology0.77800868
84MP0004043_abnormal_pH_regulation0.76780077
85MP0003111_abnormal_nucleus_morphology0.75436117
86MP0002272_abnormal_nervous_system0.75269827
87MP0000653_abnormal_sex_gland0.73945856
88MP0003890_abnormal_embryonic-extraembry0.73701946
89MP0009697_abnormal_copulation0.73431425
90MP0004142_abnormal_muscle_tone0.73428755
91MP0001286_abnormal_eye_development0.73037080
92MP0003567_abnormal_fetal_cardiomyocyte0.70618577
93MP0006054_spinal_hemorrhage0.70053224
94MP0004858_abnormal_nervous_system0.69635702
95MP0000579_abnormal_nail_morphology0.69617892
96MP0005645_abnormal_hypothalamus_physiol0.67976574
97MP0001145_abnormal_male_reproductive0.67322946
98MP0005085_abnormal_gallbladder_physiolo0.66679035
99MP0002751_abnormal_autonomic_nervous0.66064430
100MP0000627_abnormal_mammary_gland0.65184389

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the adrenal cortex (HP:0100641)4.92632728
2Glioma (HP:0009733)4.90090330
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.80924309
4Ependymoma (HP:0002888)4.29734047
5Absent rod-and cone-mediated responses on ERG (HP:0007688)4.28961778
6Congenital stationary night blindness (HP:0007642)4.15850998
7Stomach cancer (HP:0012126)3.96554965
8Colon cancer (HP:0003003)3.95463158
9Abnormality of midbrain morphology (HP:0002418)3.46005986
10Molar tooth sign on MRI (HP:0002419)3.46005986
11Pancreatic cysts (HP:0001737)3.40032552
12Astrocytoma (HP:0009592)3.29670559
13Abnormality of the astrocytes (HP:0100707)3.29670559
14Abnormal rod and cone electroretinograms (HP:0008323)3.18464802
15Pigmentary retinal degeneration (HP:0001146)3.03308568
16Chronic bronchitis (HP:0004469)3.03272042
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.02259738
18Absent/shortened dynein arms (HP:0200106)3.02259738
19Poor head control (HP:0002421)3.00724341
20Hyperventilation (HP:0002883)2.98865396
21Pancreatic fibrosis (HP:0100732)2.93360157
22Nephronophthisis (HP:0000090)2.81141693
23True hermaphroditism (HP:0010459)2.76945709
24Abnormal respiratory motile cilium physiology (HP:0012261)2.75504830
25Breast carcinoma (HP:0003002)2.74259209
26Rhinitis (HP:0012384)2.69561644
27Decreased central vision (HP:0007663)2.69199783
28Acute necrotizing encephalopathy (HP:0006965)2.67911298
29Neoplasm of the colon (HP:0100273)2.60238254
30Biliary tract neoplasm (HP:0100574)2.56635172
31Neoplasm of the adrenal gland (HP:0100631)2.54001855
32Increased CSF lactate (HP:0002490)2.48711095
33Chorioretinal atrophy (HP:0000533)2.47220516
34Agnosia (HP:0010524)2.45711890
35Intestinal atresia (HP:0011100)2.40722016
36Attenuation of retinal blood vessels (HP:0007843)2.40290241
37Abnormality of the renal medulla (HP:0100957)2.37200389
38Dyschromatopsia (HP:0007641)2.35803113
39Abnormal mitochondria in muscle tissue (HP:0008316)2.34948023
40Acute encephalopathy (HP:0006846)2.34001615
41Meckel diverticulum (HP:0002245)2.33074802
42Abnormality of the ileum (HP:0001549)2.31936054
43Progressive macrocephaly (HP:0004481)2.30950392
44Hypoplasia of the fovea (HP:0007750)2.30922496
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.30922496
46Cerebellar dysplasia (HP:0007033)2.29925927
47Abnormal ciliary motility (HP:0012262)2.29546598
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.29176357
49Inability to walk (HP:0002540)2.28289801
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.27508861
51Abnormality of the renal cortex (HP:0011035)2.24796115
52Abnormal respiratory epithelium morphology (HP:0012253)2.23893896
53Abnormal respiratory motile cilium morphology (HP:0005938)2.23893896
54Bony spicule pigmentary retinopathy (HP:0007737)2.23108217
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20891091
56Progressive microcephaly (HP:0000253)2.20801248
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20213592
58Optic nerve hypoplasia (HP:0000609)2.19975498
59Neoplasm of the oral cavity (HP:0100649)2.19244322
60Benign neoplasm of the central nervous system (HP:0100835)2.18444520
61Bile duct proliferation (HP:0001408)2.18165232
62Abnormal biliary tract physiology (HP:0012439)2.18165232
63Thyroid-stimulating hormone excess (HP:0002925)2.16870866
64Shawl scrotum (HP:0000049)2.15964369
65Narrow forehead (HP:0000341)2.14282093
66Abnormal biliary tract morphology (HP:0012440)2.13155148
67Sloping forehead (HP:0000340)2.10500836
68Ectopic kidney (HP:0000086)2.09481861
69Abnormality of the fovea (HP:0000493)2.09044896
70Poor suck (HP:0002033)2.08987250
71Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04383836
72Tubular atrophy (HP:0000092)2.01470167
73IgM deficiency (HP:0002850)1.99033198
74Short tibia (HP:0005736)1.98767196
75Rhabdomyosarcoma (HP:0002859)1.97544554
76Duodenal stenosis (HP:0100867)1.96526397
77Small intestinal stenosis (HP:0012848)1.96526397
78Abnormality of the duodenum (HP:0002246)1.90067895
79Abnormality of chromosome stability (HP:0003220)1.88865238
80Progressive inability to walk (HP:0002505)1.85758102
81Mitochondrial inheritance (HP:0001427)1.84960004
82Chromsome breakage (HP:0040012)1.84489830
83Septo-optic dysplasia (HP:0100842)1.81189897
84Volvulus (HP:0002580)1.81099001
85Cutaneous finger syndactyly (HP:0010554)1.78282631
86Astigmatism (HP:0000483)1.76768360
87Abnormality of the preputium (HP:0100587)1.75343624
88Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74962472
89Neoplasm of the small intestine (HP:0100833)1.74480732
90Type II lissencephaly (HP:0007260)1.73004201
91Generalized hypopigmentation (HP:0007513)1.72744978
92Hypoplastic iliac wings (HP:0002866)1.71929777
93Cystic liver disease (HP:0006706)1.71873127
94Neoplasm of striated muscle (HP:0009728)1.71056357
95Abnormality of the labia minora (HP:0012880)1.70517592
96Optic disc pallor (HP:0000543)1.69907912
97Broad-based gait (HP:0002136)1.69384779
98Abnormality of alanine metabolism (HP:0010916)1.68377702
99Hyperalaninemia (HP:0003348)1.68377702
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68377702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK8.22127276
2LATS14.51357297
3NUAK14.32643987
4WEE13.36346203
5FRK2.81183720
6TTK2.26018070
7TRIM282.23612407
8PLK31.96044760
9BLK1.85861341
10EPHB21.80434991
11VRK21.72612136
12STK31.69216986
13TNIK1.67977343
14WNK31.62198574
15ACVR1B1.54644917
16TAF11.51140248
17ADRBK21.50690075
18MKNK21.43192612
19PNCK1.40315219
20CCNB11.39729860
21MAP3K41.31060467
22MAP3K101.29417358
23PLK21.27589826
24STK391.23719568
25DYRK21.23680758
26EIF2AK11.23419059
27PBK1.22257146
28MAP4K21.20358281
29BMPR1B1.15706832
30TNK21.15009804
31PLK11.14821657
32EIF2AK21.13375994
33PDK21.11350884
34BUB11.11233319
35EPHA41.08621619
36CDC71.03589939
37OXSR11.02153262
38CASK1.00765480
39SRPK10.97923377
40STK38L0.96743249
41INSRR0.92377298
42CHEK20.89702871
43ATR0.82039759
44MKNK10.81534464
45PRKCG0.79679210
46GRK10.78638179
47BCR0.76257938
48MAPK130.75546681
49MELK0.74019723
50NEK20.71361478
51PLK40.70087609
52CAMKK20.69546939
53EIF2AK30.68981019
54VRK10.68884363
55NEK10.67915388
56PRKCI0.66545409
57PAK30.65879181
58CDK190.65204159
59MST40.63443004
60MAPKAPK50.62435210
61TSSK60.61277309
62ADRBK10.59144699
63ERBB30.57892878
64SIK30.56848815
65BRSK20.54273456
66PRKCE0.52864632
67CSNK1G20.50061464
68CLK10.49511764
69CSNK1G10.48934109
70WNK40.48619068
71MAP2K60.48523776
72FGFR10.46241768
73HIPK20.44919416
74ATM0.44211664
75FLT30.43357124
76PKN10.43112326
77ERBB20.42793401
78TGFBR10.42787247
79GRK50.39051458
80CAMK1D0.38811748
81STK40.36282094
82CSNK1E0.35853641
83CSNK1A1L0.32997161
84PRKAA20.32716570
85AURKB0.31470132
86PINK10.30957204
87PRKCQ0.30033639
88CSNK1G30.29695970
89MUSK0.28858066
90CAMK1G0.28213735
91CAMK40.27153045
92GSK3A0.26640731
93FER0.25719944
94MAP2K70.25331212
95MAPK120.25252057
96CAMK2A0.24760139
97CHEK10.22042117
98KSR10.21639894
99CSNK2A10.21581984
100TGFBR20.21441693

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034103.90411715
2Mismatch repair_Homo sapiens_hsa034303.76806800
3Homologous recombination_Homo sapiens_hsa034402.96691710
4Non-homologous end-joining_Homo sapiens_hsa034502.94856914
5Propanoate metabolism_Homo sapiens_hsa006402.70609988
6Fanconi anemia pathway_Homo sapiens_hsa034602.57373474
7Proteasome_Homo sapiens_hsa030502.44809307
8Phototransduction_Homo sapiens_hsa047442.41782459
9Regulation of autophagy_Homo sapiens_hsa041402.24220186
10Linoleic acid metabolism_Homo sapiens_hsa005912.08139846
11Ether lipid metabolism_Homo sapiens_hsa005651.94726079
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92463331
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92100626
14Caffeine metabolism_Homo sapiens_hsa002321.92080061
15Selenocompound metabolism_Homo sapiens_hsa004501.86149368
16One carbon pool by folate_Homo sapiens_hsa006701.78784123
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74756391
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68876106
19Cell cycle_Homo sapiens_hsa041101.61730961
20Protein export_Homo sapiens_hsa030601.45135166
21Butanoate metabolism_Homo sapiens_hsa006501.42774249
22RNA polymerase_Homo sapiens_hsa030201.40399852
23Basal transcription factors_Homo sapiens_hsa030221.39124599
24RNA transport_Homo sapiens_hsa030131.39115366
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33784764
26Nitrogen metabolism_Homo sapiens_hsa009101.32529461
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31702195
28Oxidative phosphorylation_Homo sapiens_hsa001901.31588456
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.31360572
30Nicotine addiction_Homo sapiens_hsa050331.28504283
31Pyrimidine metabolism_Homo sapiens_hsa002401.27454457
32DNA replication_Homo sapiens_hsa030301.25936502
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24477567
34Sulfur metabolism_Homo sapiens_hsa009201.22269973
35Hedgehog signaling pathway_Homo sapiens_hsa043401.20031970
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.18534567
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18453366
38Glycerolipid metabolism_Homo sapiens_hsa005611.16254498
39p53 signaling pathway_Homo sapiens_hsa041151.16114165
40Nucleotide excision repair_Homo sapiens_hsa034201.14002070
41Tryptophan metabolism_Homo sapiens_hsa003801.07935315
42Parkinsons disease_Homo sapiens_hsa050121.06962196
43Spliceosome_Homo sapiens_hsa030401.06944704
44Fatty acid degradation_Homo sapiens_hsa000711.06422540
45Huntingtons disease_Homo sapiens_hsa050160.92024003
46Pyruvate metabolism_Homo sapiens_hsa006200.91908280
47RNA degradation_Homo sapiens_hsa030180.91446784
48Lysine degradation_Homo sapiens_hsa003100.91098202
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90776327
50Fatty acid elongation_Homo sapiens_hsa000620.90436375
51Steroid biosynthesis_Homo sapiens_hsa001000.89809602
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87663685
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86684053
54Purine metabolism_Homo sapiens_hsa002300.83467008
55Fatty acid metabolism_Homo sapiens_hsa012120.83399049
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80975928
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80651331
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.78889033
59TGF-beta signaling pathway_Homo sapiens_hsa043500.78078499
60Olfactory transduction_Homo sapiens_hsa047400.77558675
61Oocyte meiosis_Homo sapiens_hsa041140.74918387
62Glutathione metabolism_Homo sapiens_hsa004800.74044390
63Basal cell carcinoma_Homo sapiens_hsa052170.73295082
64Chemical carcinogenesis_Homo sapiens_hsa052040.69873046
65Metabolic pathways_Homo sapiens_hsa011000.69364768
66Circadian rhythm_Homo sapiens_hsa047100.66742885
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63871678
68Retinol metabolism_Homo sapiens_hsa008300.63070338
69Morphine addiction_Homo sapiens_hsa050320.62365769
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.61925324
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.61785978
72Ovarian steroidogenesis_Homo sapiens_hsa049130.61162087
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59614041
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57628822
75Fat digestion and absorption_Homo sapiens_hsa049750.56828249
76Taste transduction_Homo sapiens_hsa047420.55321567
77Peroxisome_Homo sapiens_hsa041460.54798559
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54756353
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53709595
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.53233078
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51167644
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50690310
83Arachidonic acid metabolism_Homo sapiens_hsa005900.50340539
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50082124
85N-Glycan biosynthesis_Homo sapiens_hsa005100.50008587
86Asthma_Homo sapiens_hsa053100.46912345
87Alzheimers disease_Homo sapiens_hsa050100.46600772
88PPAR signaling pathway_Homo sapiens_hsa033200.45690785
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45132511
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44219073
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44076110
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.42082757
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42033636
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37453434
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36084395
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33591975
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33405957
98Hippo signaling pathway_Homo sapiens_hsa043900.32507854
99beta-Alanine metabolism_Homo sapiens_hsa004100.27570097
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27086040

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