

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit biogenesis (GO:0042274) | 5.42015089 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 5.39036944 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.39036944 |
| 4 | chaperone-mediated protein transport (GO:0072321) | 5.06791869 |
| 5 | ribosomal small subunit assembly (GO:0000028) | 5.04633067 |
| 6 | negative regulation of mast cell activation (GO:0033004) | 5.02842229 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 4.94160690 |
| 8 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.77050881 |
| 9 | viral transcription (GO:0019083) | 4.65115117 |
| 10 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.58474545 |
| 11 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.58474545 |
| 12 | NADH dehydrogenase complex assembly (GO:0010257) | 4.58474545 |
| 13 | translational termination (GO:0006415) | 4.52359027 |
| 14 | ribosomal large subunit biogenesis (GO:0042273) | 4.49689952 |
| 15 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.38360102 |
| 16 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.37528360 |
| 17 | protein targeting to ER (GO:0045047) | 4.31496244 |
| 18 | cotranslational protein targeting to membrane (GO:0006613) | 4.30156978 |
| 19 | behavioral response to nicotine (GO:0035095) | 4.29693875 |
| 20 | protein complex biogenesis (GO:0070271) | 4.28338199 |
| 21 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 4.24420306 |
| 22 | proteasome assembly (GO:0043248) | 4.18773280 |
| 23 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.16751216 |
| 24 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.15991796 |
| 25 | termination of RNA polymerase III transcription (GO:0006386) | 4.15991796 |
| 26 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.11226193 |
| 27 | GTP biosynthetic process (GO:0006183) | 4.10454017 |
| 28 | protein localization to endoplasmic reticulum (GO:0070972) | 4.08047261 |
| 29 | translational elongation (GO:0006414) | 4.00553215 |
| 30 | peptidyl-histidine modification (GO:0018202) | 3.99564744 |
| 31 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.97387270 |
| 32 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.93967831 |
| 33 | regulation of activation of Janus kinase activity (GO:0010533) | 3.89832601 |
| 34 | regulation of immunoglobulin secretion (GO:0051023) | 3.85126658 |
| 35 | cellular component biogenesis (GO:0044085) | 3.78892240 |
| 36 | DNA deamination (GO:0045006) | 3.78838970 |
| 37 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.78452570 |
| 38 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.78216655 |
| 39 | rRNA processing (GO:0006364) | 3.77380310 |
| 40 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.77033980 |
| 41 | maturation of 5.8S rRNA (GO:0000460) | 3.72176082 |
| 42 | translation (GO:0006412) | 3.71596998 |
| 43 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.71417507 |
| 44 | DNA replication checkpoint (GO:0000076) | 3.69704367 |
| 45 | rRNA metabolic process (GO:0016072) | 3.64955018 |
| 46 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.64523903 |
| 47 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.64523903 |
| 48 | UTP biosynthetic process (GO:0006228) | 3.63504349 |
| 49 | ncRNA 3-end processing (GO:0043628) | 3.60490299 |
| 50 | viral life cycle (GO:0019058) | 3.56695375 |
| 51 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.55938314 |
| 52 | respiratory electron transport chain (GO:0022904) | 3.53303357 |
| 53 | electron transport chain (GO:0022900) | 3.53038741 |
| 54 | translational initiation (GO:0006413) | 3.48545145 |
| 55 | DNA damage response, detection of DNA damage (GO:0042769) | 3.48371049 |
| 56 | signal peptide processing (GO:0006465) | 3.47660573 |
| 57 | protein neddylation (GO:0045116) | 3.46355996 |
| 58 | cellular protein complex disassembly (GO:0043624) | 3.45312296 |
| 59 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.43407872 |
| 60 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.40640565 |
| 61 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.40111896 |
| 62 | negative regulation of ligase activity (GO:0051352) | 3.40111896 |
| 63 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.39196940 |
| 64 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.38403704 |
| 65 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.36217302 |
| 66 | response to redox state (GO:0051775) | 3.33041343 |
| 67 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.26624278 |
| 68 | pseudouridine synthesis (GO:0001522) | 3.25833496 |
| 69 | rRNA modification (GO:0000154) | 3.24904856 |
| 70 | UTP metabolic process (GO:0046051) | 3.21076839 |
| 71 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.18192156 |
| 72 | formation of translation preinitiation complex (GO:0001731) | 3.16815822 |
| 73 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.16145992 |
| 74 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.16145992 |
| 75 | ATP biosynthetic process (GO:0006754) | 3.15650974 |
| 76 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.15469130 |
| 77 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.15469130 |
| 78 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.15469130 |
| 79 | piRNA metabolic process (GO:0034587) | 3.14668402 |
| 80 | protein targeting to mitochondrion (GO:0006626) | 3.14511723 |
| 81 | respiratory chain complex IV assembly (GO:0008535) | 3.13355372 |
| 82 | tRNA processing (GO:0008033) | 3.13213445 |
| 83 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.09200748 |
| 84 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.09200748 |
| 85 | rRNA methylation (GO:0031167) | 3.07784779 |
| 86 | establishment of protein localization to mitochondrion (GO:0072655) | 3.07749662 |
| 87 | negative regulation of B cell apoptotic process (GO:0002903) | 3.06724335 |
| 88 | positive regulation of prostaglandin secretion (GO:0032308) | 3.05892464 |
| 89 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.05208561 |
| 90 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.04369662 |
| 91 | RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502) | 3.04345476 |
| 92 | CTP metabolic process (GO:0046036) | 3.03442523 |
| 93 | CTP biosynthetic process (GO:0006241) | 3.03442523 |
| 94 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.02738718 |
| 95 | ncRNA processing (GO:0034470) | 3.02395000 |
| 96 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.01273421 |
| 97 | protein complex disassembly (GO:0043241) | 2.99399604 |
| 98 | ribosome biogenesis (GO:0042254) | 2.97886448 |
| 99 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.92547373 |
| 100 | intracellular protein transmembrane import (GO:0044743) | 2.90110018 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.59024847 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.54952470 |
| 3 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.49963073 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.81899662 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.73958544 |
| 6 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.49644574 |
| 7 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 3.47110773 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.46508313 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.43232641 |
| 10 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.16654985 |
| 11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.06365447 |
| 12 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.95555216 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.85122492 |
| 14 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.82175866 |
| 15 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.60005406 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.42654008 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.40454839 |
| 18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.35115208 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.33839234 |
| 20 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.27929112 |
| 21 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.26490773 |
| 22 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.19559288 |
| 23 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.13403357 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.13010852 |
| 25 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.12170307 |
| 26 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.09553488 |
| 27 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.06671023 |
| 28 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.99211533 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.93787300 |
| 30 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.93121358 |
| 31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.91046773 |
| 32 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.87786182 |
| 33 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.87151260 |
| 34 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.86407000 |
| 35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.86105951 |
| 36 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.85731731 |
| 37 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.82085182 |
| 38 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.70269741 |
| 39 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.67471855 |
| 40 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.67215279 |
| 41 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.59117586 |
| 42 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.55822834 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.51766268 |
| 44 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.46768919 |
| 45 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.42898617 |
| 46 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.42150869 |
| 47 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.41259881 |
| 48 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.37726872 |
| 49 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.31606325 |
| 50 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.30944862 |
| 51 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.29857937 |
| 52 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.29483779 |
| 53 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.27548531 |
| 54 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27497082 |
| 55 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.26916947 |
| 56 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.26598722 |
| 57 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.25065364 |
| 58 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.24637296 |
| 59 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.21053248 |
| 60 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.15370573 |
| 61 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.09898693 |
| 62 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.08398505 |
| 63 | VDR_22108803_ChIP-Seq_LS180_Human | 1.08289546 |
| 64 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.08146114 |
| 65 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.06616687 |
| 66 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.05867084 |
| 67 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.04430288 |
| 68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.02656769 |
| 69 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.02158349 |
| 70 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99789161 |
| 71 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.99225378 |
| 72 | ERA_21632823_ChIP-Seq_H3396_Human | 0.98951654 |
| 73 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.94930320 |
| 74 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.94708003 |
| 75 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.94123892 |
| 76 | NCOR_22424771_ChIP-Seq_293T_Human | 0.93797173 |
| 77 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.93777364 |
| 78 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.93777170 |
| 79 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.92691388 |
| 80 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.90527125 |
| 81 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.89784552 |
| 82 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.89536602 |
| 83 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.89161249 |
| 84 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.88859788 |
| 85 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.87841577 |
| 86 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86978187 |
| 87 | EWS_26573619_Chip-Seq_HEK293_Human | 0.86420585 |
| 88 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.85646056 |
| 89 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.85292961 |
| 90 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.85015168 |
| 91 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.84599220 |
| 92 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82849169 |
| 93 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.82402139 |
| 94 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.82402139 |
| 95 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.82074100 |
| 96 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.80691039 |
| 97 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.80519399 |
| 98 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.80151005 |
| 99 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.79543291 |
| 100 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.77119674 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 4.18515400 |
| 2 | MP0003646_muscle_fatigue | 3.90245343 |
| 3 | MP0009379_abnormal_foot_pigmentation | 3.74372163 |
| 4 | MP0008877_abnormal_DNA_methylation | 3.54889201 |
| 5 | MP0002102_abnormal_ear_morphology | 3.10616506 |
| 6 | MP0008875_abnormal_xenobiotic_pharmacok | 3.01617723 |
| 7 | MP0003693_abnormal_embryo_hatching | 2.49743314 |
| 8 | MP0005645_abnormal_hypothalamus_physiol | 2.26667403 |
| 9 | MP0006276_abnormal_autonomic_nervous | 2.16456117 |
| 10 | MP0003878_abnormal_ear_physiology | 2.15405091 |
| 11 | MP0005377_hearing/vestibular/ear_phenot | 2.15405091 |
| 12 | MP0002138_abnormal_hepatobiliary_system | 2.11509903 |
| 13 | MP0001529_abnormal_vocalization | 2.05532516 |
| 14 | MP0004142_abnormal_muscle_tone | 2.04716422 |
| 15 | MP0003787_abnormal_imprinting | 2.04184668 |
| 16 | MP0005084_abnormal_gallbladder_morpholo | 1.98512452 |
| 17 | MP0001919_abnormal_reproductive_system | 1.97122058 |
| 18 | MP0003122_maternal_imprinting | 1.91199857 |
| 19 | MP0005394_taste/olfaction_phenotype | 1.83336284 |
| 20 | MP0005499_abnormal_olfactory_system | 1.83336284 |
| 21 | MP0008789_abnormal_olfactory_epithelium | 1.82944982 |
| 22 | MP0008058_abnormal_DNA_repair | 1.76618890 |
| 23 | MP0003786_premature_aging | 1.75218590 |
| 24 | MP0006072_abnormal_retinal_apoptosis | 1.68944484 |
| 25 | MP0008872_abnormal_physiological_respon | 1.68146536 |
| 26 | MP0002653_abnormal_ependyma_morphology | 1.57330707 |
| 27 | MP0005389_reproductive_system_phenotype | 1.57212352 |
| 28 | MP0004742_abnormal_vestibular_system | 1.50724647 |
| 29 | MP0003195_calcinosis | 1.50629375 |
| 30 | MP0003186_abnormal_redox_activity | 1.47924364 |
| 31 | MP0004957_abnormal_blastocyst_morpholog | 1.46455219 |
| 32 | MP0006036_abnormal_mitochondrial_physio | 1.46076266 |
| 33 | MP0003718_maternal_effect | 1.45313549 |
| 34 | MP0002210_abnormal_sex_determination | 1.43684147 |
| 35 | MP0001293_anophthalmia | 1.43243255 |
| 36 | MP0005551_abnormal_eye_electrophysiolog | 1.34782616 |
| 37 | MP0001984_abnormal_olfaction | 1.34263092 |
| 38 | MP0003567_abnormal_fetal_cardiomyocyte | 1.32806058 |
| 39 | MP0001348_abnormal_lacrimal_gland | 1.27500653 |
| 40 | MP0001929_abnormal_gametogenesis | 1.26659086 |
| 41 | MP0005360_urolithiasis | 1.22556817 |
| 42 | MP0000049_abnormal_middle_ear | 1.18985220 |
| 43 | MP0009046_muscle_twitch | 1.18090326 |
| 44 | MP0002163_abnormal_gland_morphology | 1.17997979 |
| 45 | MP0001853_heart_inflammation | 1.14978174 |
| 46 | MP0002837_dystrophic_cardiac_calcinosis | 1.14848313 |
| 47 | MP0001905_abnormal_dopamine_level | 1.12524354 |
| 48 | MP0002736_abnormal_nociception_after | 1.11043364 |
| 49 | MP0010094_abnormal_chromosome_stability | 1.11033955 |
| 50 | MP0001502_abnormal_circadian_rhythm | 1.10853954 |
| 51 | MP0004885_abnormal_endolymph | 1.09258575 |
| 52 | MP0002557_abnormal_social/conspecific_i | 1.07572534 |
| 53 | MP0000465_gastrointestinal_hemorrhage | 1.05258967 |
| 54 | MP0001485_abnormal_pinna_reflex | 1.05144465 |
| 55 | MP0003121_genomic_imprinting | 1.05017848 |
| 56 | MP0010386_abnormal_urinary_bladder | 1.02258721 |
| 57 | MP0001661_extended_life_span | 1.00524727 |
| 58 | MP0001968_abnormal_touch/_nociception | 0.99687891 |
| 59 | MP0005365_abnormal_bile_salt | 0.99505237 |
| 60 | MP0002160_abnormal_reproductive_system | 0.98808011 |
| 61 | MP0000653_abnormal_sex_gland | 0.98805758 |
| 62 | MP0003119_abnormal_digestive_system | 0.97512137 |
| 63 | MP0001145_abnormal_male_reproductive | 0.96937597 |
| 64 | MP0005085_abnormal_gallbladder_physiolo | 0.96498251 |
| 65 | MP0004145_abnormal_muscle_electrophysio | 0.95479557 |
| 66 | MP0002876_abnormal_thyroid_physiology | 0.93024019 |
| 67 | MP0003938_abnormal_ear_development | 0.92978138 |
| 68 | MP0005410_abnormal_fertilization | 0.91807545 |
| 69 | MP0003698_abnormal_male_reproductive | 0.88825890 |
| 70 | MP0009745_abnormal_behavioral_response | 0.88313247 |
| 71 | MP0001119_abnormal_female_reproductive | 0.88266733 |
| 72 | MP0005636_abnormal_mineral_homeostasis | 0.87418580 |
| 73 | MP0002277_abnormal_respiratory_mucosa | 0.87366775 |
| 74 | MP0002272_abnormal_nervous_system | 0.86965826 |
| 75 | MP0005174_abnormal_tail_pigmentation | 0.84256321 |
| 76 | MP0006035_abnormal_mitochondrial_morpho | 0.83734826 |
| 77 | MP0008932_abnormal_embryonic_tissue | 0.82772852 |
| 78 | MP0005332_abnormal_amino_acid | 0.82273718 |
| 79 | MP0001835_abnormal_antigen_presentation | 0.81287002 |
| 80 | MP0008995_early_reproductive_senescence | 0.80607771 |
| 81 | MP0001873_stomach_inflammation | 0.80091620 |
| 82 | MP0002733_abnormal_thermal_nociception | 0.80002913 |
| 83 | MP0009764_decreased_sensitivity_to | 0.79744224 |
| 84 | MP0005167_abnormal_blood-brain_barrier | 0.79528079 |
| 85 | MP0003123_paternal_imprinting | 0.79000722 |
| 86 | MP0004019_abnormal_vitamin_homeostasis | 0.78147509 |
| 87 | MP0001501_abnormal_sleep_pattern | 0.77980737 |
| 88 | MP0003252_abnormal_bile_duct | 0.77708631 |
| 89 | MP0003806_abnormal_nucleotide_metabolis | 0.76635302 |
| 90 | MP0005195_abnormal_posterior_eye | 0.76040418 |
| 91 | MP0001188_hyperpigmentation | 0.75829256 |
| 92 | MP0005253_abnormal_eye_physiology | 0.73936724 |
| 93 | MP0000631_abnormal_neuroendocrine_gland | 0.73008536 |
| 94 | MP0000015_abnormal_ear_pigmentation | 0.72800210 |
| 95 | MP0005646_abnormal_pituitary_gland | 0.72387988 |
| 96 | MP0000026_abnormal_inner_ear | 0.70381269 |
| 97 | MP0003937_abnormal_limbs/digits/tail_de | 0.69500098 |
| 98 | MP0008775_abnormal_heart_ventricle | 0.68395355 |
| 99 | MP0004133_heterotaxia | 0.68357261 |
| 100 | MP0002938_white_spotting | 0.67919460 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.29900418 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.72922698 |
| 3 | Acute encephalopathy (HP:0006846) | 4.55804571 |
| 4 | 3-Methylglutaconic aciduria (HP:0003535) | 4.36605427 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.29858749 |
| 6 | Reticulocytopenia (HP:0001896) | 4.25794850 |
| 7 | Increased CSF lactate (HP:0002490) | 4.09791540 |
| 8 | Mitochondrial inheritance (HP:0001427) | 4.08957671 |
| 9 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 3.94988131 |
| 10 | Microvesicular hepatic steatosis (HP:0001414) | 3.66240087 |
| 11 | Cerebral edema (HP:0002181) | 3.47230954 |
| 12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.36705746 |
| 13 | Increased hepatocellular lipid droplets (HP:0006565) | 3.34912792 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.25232542 |
| 15 | Increased serum lactate (HP:0002151) | 3.12362443 |
| 16 | Renal Fanconi syndrome (HP:0001994) | 3.05869352 |
| 17 | Increased intramyocellular lipid droplets (HP:0012240) | 2.95726793 |
| 18 | Molar tooth sign on MRI (HP:0002419) | 2.95129278 |
| 19 | Abnormality of midbrain morphology (HP:0002418) | 2.95129278 |
| 20 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.94662472 |
| 21 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.90634467 |
| 22 | Hepatic necrosis (HP:0002605) | 2.85632086 |
| 23 | Abnormal biliary tract physiology (HP:0012439) | 2.82263883 |
| 24 | Bile duct proliferation (HP:0001408) | 2.82263883 |
| 25 | Type II lissencephaly (HP:0007260) | 2.78154117 |
| 26 | Macrocytic anemia (HP:0001972) | 2.74992679 |
| 27 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.74210760 |
| 28 | Increased serum pyruvate (HP:0003542) | 2.73528922 |
| 29 | Testicular atrophy (HP:0000029) | 2.72955820 |
| 30 | Optic disc pallor (HP:0000543) | 2.67730503 |
| 31 | Abnormal number of erythroid precursors (HP:0012131) | 2.65163218 |
| 32 | Renovascular hypertension (HP:0100817) | 2.64400184 |
| 33 | Pendular nystagmus (HP:0012043) | 2.62280918 |
| 34 | Exercise intolerance (HP:0003546) | 2.61112866 |
| 35 | Hepatocellular necrosis (HP:0001404) | 2.60492555 |
| 36 | Lactic acidosis (HP:0003128) | 2.58266404 |
| 37 | Increased muscle lipid content (HP:0009058) | 2.57705255 |
| 38 | Methylmalonic aciduria (HP:0012120) | 2.52351465 |
| 39 | Nephronophthisis (HP:0000090) | 2.50146963 |
| 40 | Colon cancer (HP:0003003) | 2.47853856 |
| 41 | Abnormality of urine glucose concentration (HP:0011016) | 2.47728729 |
| 42 | Glycosuria (HP:0003076) | 2.47728729 |
| 43 | Polydipsia (HP:0001959) | 2.44918002 |
| 44 | Abnormal drinking behavior (HP:0030082) | 2.44918002 |
| 45 | Severe visual impairment (HP:0001141) | 2.43899848 |
| 46 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.42719043 |
| 47 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.42719043 |
| 48 | Absent thumb (HP:0009777) | 2.41993790 |
| 49 | Abnormality of the labia minora (HP:0012880) | 2.39630015 |
| 50 | Respiratory failure (HP:0002878) | 2.33462622 |
| 51 | Leukodystrophy (HP:0002415) | 2.32817089 |
| 52 | Abnormality of the renal cortex (HP:0011035) | 2.30709041 |
| 53 | Lethargy (HP:0001254) | 2.29428618 |
| 54 | Abnormality of glycolysis (HP:0004366) | 2.28206910 |
| 55 | Methylmalonic acidemia (HP:0002912) | 2.26559731 |
| 56 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.26279362 |
| 57 | Dicarboxylic aciduria (HP:0003215) | 2.26279362 |
| 58 | Generalized aminoaciduria (HP:0002909) | 2.23698353 |
| 59 | Pachygyria (HP:0001302) | 2.22661906 |
| 60 | Overriding aorta (HP:0002623) | 2.19984012 |
| 61 | Hyperglycinemia (HP:0002154) | 2.18799054 |
| 62 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.17591280 |
| 63 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.17324744 |
| 64 | Abnormality of alanine metabolism (HP:0010916) | 2.17324744 |
| 65 | Hyperalaninemia (HP:0003348) | 2.17324744 |
| 66 | Congenital stationary night blindness (HP:0007642) | 2.14734738 |
| 67 | Respiratory difficulties (HP:0002880) | 2.14257622 |
| 68 | Elfin facies (HP:0004428) | 2.12717338 |
| 69 | Agitation (HP:0000713) | 2.12679557 |
| 70 | Pancreatic cysts (HP:0001737) | 2.11308938 |
| 71 | Pallor (HP:0000980) | 2.09121361 |
| 72 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.07777437 |
| 73 | Exertional dyspnea (HP:0002875) | 2.06869390 |
| 74 | Abnormality of the renal medulla (HP:0100957) | 1.97325662 |
| 75 | Tubular atrophy (HP:0000092) | 1.92921482 |
| 76 | Lissencephaly (HP:0001339) | 1.91797612 |
| 77 | Renal cortical cysts (HP:0000803) | 1.90114190 |
| 78 | Confusion (HP:0001289) | 1.89307643 |
| 79 | Hypoglycemic coma (HP:0001325) | 1.85374334 |
| 80 | Hypoplasia of the radius (HP:0002984) | 1.85137674 |
| 81 | Polyuria (HP:0000103) | 1.84907036 |
| 82 | Abolished electroretinogram (ERG) (HP:0000550) | 1.82988448 |
| 83 | Abnormality of the carotid arteries (HP:0005344) | 1.81257993 |
| 84 | Chromsome breakage (HP:0040012) | 1.80603871 |
| 85 | Pancytopenia (HP:0001876) | 1.77397064 |
| 86 | Horseshoe kidney (HP:0000085) | 1.75977749 |
| 87 | Opisthotonus (HP:0002179) | 1.74816185 |
| 88 | Abnormality of the diencephalon (HP:0010662) | 1.74268852 |
| 89 | Constricted visual fields (HP:0001133) | 1.74222036 |
| 90 | Pancreatic fibrosis (HP:0100732) | 1.74076695 |
| 91 | Ependymoma (HP:0002888) | 1.73695657 |
| 92 | Hypomagnesemia (HP:0002917) | 1.73324882 |
| 93 | Degeneration of anterior horn cells (HP:0002398) | 1.72778268 |
| 94 | Abnormality of the anterior horn cell (HP:0006802) | 1.72778268 |
| 95 | Cerebral hypomyelination (HP:0006808) | 1.72617933 |
| 96 | Hypoplasia of the pons (HP:0012110) | 1.70937837 |
| 97 | X-linked dominant inheritance (HP:0001423) | 1.70470388 |
| 98 | Congenital, generalized hypertrichosis (HP:0004540) | 1.69434833 |
| 99 | Oligodactyly (HP:0012165) | 1.69366002 |
| 100 | Ragged-red muscle fibers (HP:0003200) | 1.68826893 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TLK1 | 4.27858382 |
| 2 | LIMK1 | 3.63641570 |
| 3 | ZAK | 3.36255848 |
| 4 | TRIM28 | 2.80772131 |
| 5 | CDC7 | 2.79409605 |
| 6 | SRPK1 | 2.72239026 |
| 7 | BCKDK | 2.49942877 |
| 8 | TIE1 | 2.48249697 |
| 9 | BUB1 | 2.37272415 |
| 10 | STK16 | 2.37010491 |
| 11 | BMPR1B | 2.33082689 |
| 12 | TSSK6 | 2.28340134 |
| 13 | PBK | 2.16749984 |
| 14 | ADRBK2 | 2.16211789 |
| 15 | WNK4 | 2.09773676 |
| 16 | GRK1 | 2.09633950 |
| 17 | CDK8 | 1.92995024 |
| 18 | NME2 | 1.92717215 |
| 19 | CDK19 | 1.88772546 |
| 20 | TXK | 1.84077648 |
| 21 | VRK2 | 1.67436361 |
| 22 | BRSK1 | 1.58880069 |
| 23 | DYRK2 | 1.55188201 |
| 24 | VRK1 | 1.47460401 |
| 25 | PDK2 | 1.47354847 |
| 26 | EIF2AK1 | 1.46229736 |
| 27 | CAMKK2 | 1.42985344 |
| 28 | MST4 | 1.41420271 |
| 29 | AURKA | 1.38649669 |
| 30 | RPS6KA5 | 1.36333505 |
| 31 | PINK1 | 1.36184049 |
| 32 | STK39 | 1.29883349 |
| 33 | NME1 | 1.26330096 |
| 34 | NEK1 | 1.23147756 |
| 35 | PLK1 | 1.10483699 |
| 36 | CSNK1G2 | 1.07869199 |
| 37 | CSNK1G3 | 1.06671560 |
| 38 | ATR | 1.05581242 |
| 39 | MAP4K1 | 1.00621719 |
| 40 | NUAK1 | 1.00097226 |
| 41 | CDC42BPA | 0.94343404 |
| 42 | ITK | 0.90806532 |
| 43 | FRK | 0.89885842 |
| 44 | PLK3 | 0.89433945 |
| 45 | CSNK1G1 | 0.88369604 |
| 46 | ICK | 0.87060344 |
| 47 | CSNK1A1L | 0.86446314 |
| 48 | TEC | 0.85542402 |
| 49 | MAP3K11 | 0.84722608 |
| 50 | ALK | 0.80937466 |
| 51 | INSRR | 0.80412203 |
| 52 | OXSR1 | 0.76677838 |
| 53 | CHEK1 | 0.76631835 |
| 54 | CSNK2A2 | 0.75191947 |
| 55 | AURKB | 0.73795697 |
| 56 | CAMK1D | 0.72482813 |
| 57 | EPHB2 | 0.68495561 |
| 58 | PRKCG | 0.68406678 |
| 59 | TNIK | 0.66755264 |
| 60 | EIF2AK3 | 0.64679134 |
| 61 | CAMKK1 | 0.62904059 |
| 62 | BCR | 0.61464396 |
| 63 | NTRK2 | 0.59242335 |
| 64 | AKT2 | 0.57240655 |
| 65 | MAP4K2 | 0.56826118 |
| 66 | CSNK1E | 0.56503701 |
| 67 | PAK4 | 0.55867444 |
| 68 | CSNK2A1 | 0.53666147 |
| 69 | CDK7 | 0.51737167 |
| 70 | PIK3CA | 0.50445077 |
| 71 | CHEK2 | 0.50326008 |
| 72 | FES | 0.50055931 |
| 73 | MKNK2 | 0.49229751 |
| 74 | PRKCQ | 0.46693424 |
| 75 | ACVR1B | 0.44391447 |
| 76 | KDR | 0.41721208 |
| 77 | WNK3 | 0.40841551 |
| 78 | CLK1 | 0.40728108 |
| 79 | CCNB1 | 0.40172306 |
| 80 | PAK3 | 0.38102523 |
| 81 | CAMK1 | 0.37904395 |
| 82 | MAPK11 | 0.37107210 |
| 83 | DAPK3 | 0.37075862 |
| 84 | STK4 | 0.35528415 |
| 85 | PTK6 | 0.34582417 |
| 86 | TAF1 | 0.33298770 |
| 87 | PRKCI | 0.33111952 |
| 88 | EIF2AK2 | 0.32585763 |
| 89 | ATM | 0.32208367 |
| 90 | IRAK4 | 0.30934014 |
| 91 | CSNK1D | 0.29408448 |
| 92 | MAP3K9 | 0.29102205 |
| 93 | IKBKB | 0.29080002 |
| 94 | CDK1 | 0.28873600 |
| 95 | PHKG2 | 0.28862025 |
| 96 | PHKG1 | 0.28862025 |
| 97 | MAP2K2 | 0.28389045 |
| 98 | ABL2 | 0.27825350 |
| 99 | PRKACA | 0.27780170 |
| 100 | PAK1 | 0.27408426 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.21137224 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.91456038 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.63921032 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.35061791 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.11161434 |
| 6 | Protein export_Homo sapiens_hsa03060 | 3.04482842 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.50742363 |
| 8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.21763666 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.09765390 |
| 10 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.04269753 |
| 11 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.89417354 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.88199048 |
| 13 | Sulfur relay system_Homo sapiens_hsa04122 | 1.85042620 |
| 14 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.80697010 |
| 15 | Alzheimers disease_Homo sapiens_hsa05010 | 1.80031682 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 1.75767549 |
| 17 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.75696031 |
| 18 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.72755043 |
| 19 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.68396629 |
| 20 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.68317437 |
| 21 | Spliceosome_Homo sapiens_hsa03040 | 1.68217490 |
| 22 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.60232286 |
| 23 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.49849367 |
| 24 | Homologous recombination_Homo sapiens_hsa03440 | 1.49591878 |
| 25 | Mismatch repair_Homo sapiens_hsa03430 | 1.49060619 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.48385163 |
| 27 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.47915805 |
| 28 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.46177502 |
| 29 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.43871049 |
| 30 | Basal transcription factors_Homo sapiens_hsa03022 | 1.41004259 |
| 31 | RNA transport_Homo sapiens_hsa03013 | 1.39530527 |
| 32 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.32333957 |
| 33 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.30900983 |
| 34 | Peroxisome_Homo sapiens_hsa04146 | 1.30861173 |
| 35 | Base excision repair_Homo sapiens_hsa03410 | 1.29916238 |
| 36 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.27733907 |
| 37 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.27540061 |
| 38 | Phototransduction_Homo sapiens_hsa04744 | 1.25248509 |
| 39 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.14907420 |
| 40 | Alcoholism_Homo sapiens_hsa05034 | 1.13986461 |
| 41 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.06482906 |
| 42 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.04355368 |
| 43 | Allograft rejection_Homo sapiens_hsa05330 | 1.02333412 |
| 44 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.98862009 |
| 45 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.98778204 |
| 46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.98496336 |
| 47 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.98418752 |
| 48 | Asthma_Homo sapiens_hsa05310 | 0.96998087 |
| 49 | Purine metabolism_Homo sapiens_hsa00230 | 0.95956323 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.94665162 |
| 51 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.90538831 |
| 52 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.90535749 |
| 53 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.88243153 |
| 54 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.84299685 |
| 55 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.82639473 |
| 56 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.79407010 |
| 57 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.76762717 |
| 58 | Metabolic pathways_Homo sapiens_hsa01100 | 0.74489581 |
| 59 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.72166024 |
| 60 | Carbon metabolism_Homo sapiens_hsa01200 | 0.71143230 |
| 61 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.70461395 |
| 62 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.69348801 |
| 63 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.69320241 |
| 64 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.69042197 |
| 65 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.66604991 |
| 66 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.63538995 |
| 67 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.61246729 |
| 68 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.61198156 |
| 69 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.60807004 |
| 70 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.55806972 |
| 71 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.54123419 |
| 72 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.53989952 |
| 73 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.53841148 |
| 74 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.53769794 |
| 75 | Cell cycle_Homo sapiens_hsa04110 | 0.53093143 |
| 76 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.51010253 |
| 77 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.47871786 |
| 78 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.46702496 |
| 79 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.45923893 |
| 80 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.45531456 |
| 81 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.43813306 |
| 82 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.42949771 |
| 83 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.41539199 |
| 84 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.39328404 |
| 85 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.38847029 |
| 86 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.38112641 |
| 87 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.32720194 |
| 88 | Nicotine addiction_Homo sapiens_hsa05033 | 0.31363626 |
| 89 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.30128891 |
| 90 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.29954832 |
| 91 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.29923443 |
| 92 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.27765228 |
| 93 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.27759226 |
| 94 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.25478525 |
| 95 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.24942329 |
| 96 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.24863636 |
| 97 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.24758300 |
| 98 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.24427426 |
| 99 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.24324189 |
| 100 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.22786487 |

