RPS5P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.42015089
2ATP synthesis coupled proton transport (GO:0015986)5.39036944
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.39036944
4chaperone-mediated protein transport (GO:0072321)5.06791869
5ribosomal small subunit assembly (GO:0000028)5.04633067
6negative regulation of mast cell activation (GO:0033004)5.02842229
7maturation of SSU-rRNA (GO:0030490)4.94160690
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.77050881
9viral transcription (GO:0019083)4.65115117
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.58474545
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.58474545
12NADH dehydrogenase complex assembly (GO:0010257)4.58474545
13translational termination (GO:0006415)4.52359027
14ribosomal large subunit biogenesis (GO:0042273)4.49689952
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.38360102
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.37528360
17protein targeting to ER (GO:0045047)4.31496244
18cotranslational protein targeting to membrane (GO:0006613)4.30156978
19behavioral response to nicotine (GO:0035095)4.29693875
20protein complex biogenesis (GO:0070271)4.28338199
21positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.24420306
22proteasome assembly (GO:0043248)4.18773280
23establishment of protein localization to endoplasmic reticulum (GO:0072599)4.16751216
24transcription elongation from RNA polymerase III promoter (GO:0006385)4.15991796
25termination of RNA polymerase III transcription (GO:0006386)4.15991796
26water-soluble vitamin biosynthetic process (GO:0042364)4.11226193
27GTP biosynthetic process (GO:0006183)4.10454017
28protein localization to endoplasmic reticulum (GO:0070972)4.08047261
29translational elongation (GO:0006414)4.00553215
30peptidyl-histidine modification (GO:0018202)3.99564744
31mitochondrial respiratory chain complex assembly (GO:0033108)3.97387270
32regulation of isotype switching to IgG isotypes (GO:0048302)3.93967831
33regulation of activation of Janus kinase activity (GO:0010533)3.89832601
34regulation of immunoglobulin secretion (GO:0051023)3.85126658
35cellular component biogenesis (GO:0044085)3.78892240
36DNA deamination (GO:0045006)3.78838970
37regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.78452570
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.78216655
39rRNA processing (GO:0006364)3.77380310
40ribonucleoprotein complex biogenesis (GO:0022613)3.77033980
41maturation of 5.8S rRNA (GO:0000460)3.72176082
42translation (GO:0006412)3.71596998
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71417507
44DNA replication checkpoint (GO:0000076)3.69704367
45rRNA metabolic process (GO:0016072)3.64955018
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.64523903
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.64523903
48UTP biosynthetic process (GO:0006228)3.63504349
49ncRNA 3-end processing (GO:0043628)3.60490299
50viral life cycle (GO:0019058)3.56695375
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55938314
52respiratory electron transport chain (GO:0022904)3.53303357
53electron transport chain (GO:0022900)3.53038741
54translational initiation (GO:0006413)3.48545145
55DNA damage response, detection of DNA damage (GO:0042769)3.48371049
56signal peptide processing (GO:0006465)3.47660573
57protein neddylation (GO:0045116)3.46355996
58cellular protein complex disassembly (GO:0043624)3.45312296
59regulation of cellular amino acid metabolic process (GO:0006521)3.43407872
60purine nucleoside triphosphate biosynthetic process (GO:0009145)3.40640565
61negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40111896
62negative regulation of ligase activity (GO:0051352)3.40111896
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39196940
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.38403704
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36217302
66response to redox state (GO:0051775)3.33041343
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26624278
68pseudouridine synthesis (GO:0001522)3.25833496
69rRNA modification (GO:0000154)3.24904856
70UTP metabolic process (GO:0046051)3.21076839
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18192156
72formation of translation preinitiation complex (GO:0001731)3.16815822
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16145992
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16145992
75ATP biosynthetic process (GO:0006754)3.15650974
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15469130
77signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15469130
78signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15469130
79piRNA metabolic process (GO:0034587)3.14668402
80protein targeting to mitochondrion (GO:0006626)3.14511723
81respiratory chain complex IV assembly (GO:0008535)3.13355372
82tRNA processing (GO:0008033)3.13213445
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09200748
84signal transduction involved in DNA damage checkpoint (GO:0072422)3.09200748
85rRNA methylation (GO:0031167)3.07784779
86establishment of protein localization to mitochondrion (GO:0072655)3.07749662
87negative regulation of B cell apoptotic process (GO:0002903)3.06724335
88positive regulation of prostaglandin secretion (GO:0032308)3.05892464
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.05208561
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04369662
91RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.04345476
92CTP metabolic process (GO:0046036)3.03442523
93CTP biosynthetic process (GO:0006241)3.03442523
94ribonucleoside triphosphate biosynthetic process (GO:0009201)3.02738718
95ncRNA processing (GO:0034470)3.02395000
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01273421
97protein complex disassembly (GO:0043241)2.99399604
98ribosome biogenesis (GO:0042254)2.97886448
99pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.92547373
100intracellular protein transmembrane import (GO:0044743)2.90110018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59024847
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.54952470
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.49963073
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.81899662
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73958544
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.49644574
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.47110773
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.46508313
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.43232641
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.16654985
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.06365447
12E2F7_22180533_ChIP-Seq_HELA_Human2.95555216
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85122492
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82175866
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60005406
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42654008
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40454839
18VDR_23849224_ChIP-Seq_CD4+_Human2.35115208
19XRN2_22483619_ChIP-Seq_HELA_Human2.33839234
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27929112
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.26490773
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19559288
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13403357
24FOXP3_21729870_ChIP-Seq_TREG_Human2.13010852
25TTF2_22483619_ChIP-Seq_HELA_Human2.12170307
26ZNF274_21170338_ChIP-Seq_K562_Hela2.09553488
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06671023
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.99211533
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93787300
30GABP_19822575_ChIP-Seq_HepG2_Human1.93121358
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.91046773
32ELK1_19687146_ChIP-ChIP_HELA_Human1.87786182
33MYC_18940864_ChIP-ChIP_HL60_Human1.87151260
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86407000
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86105951
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.85731731
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82085182
38IRF1_19129219_ChIP-ChIP_H3396_Human1.70269741
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67471855
40DCP1A_22483619_ChIP-Seq_HELA_Human1.67215279
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59117586
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55822834
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51766268
44EZH2_22144423_ChIP-Seq_EOC_Human1.46768919
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42898617
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42150869
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41259881
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37726872
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31606325
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30944862
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29857937
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29483779
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27548531
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27497082
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26916947
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26598722
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25065364
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24637296
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21053248
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15370573
61TP53_22573176_ChIP-Seq_HFKS_Human1.09898693
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08398505
63VDR_22108803_ChIP-Seq_LS180_Human1.08289546
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08146114
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06616687
66CIITA_25753668_ChIP-Seq_RAJI_Human1.05867084
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.04430288
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02656769
69KDM5A_27292631_Chip-Seq_BREAST_Human1.02158349
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99789161
71SOX2_16153702_ChIP-ChIP_HESCs_Human0.99225378
72ERA_21632823_ChIP-Seq_H3396_Human0.98951654
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94930320
74BCL6_27268052_Chip-Seq_Bcells_Human0.94708003
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94123892
76NCOR_22424771_ChIP-Seq_293T_Human0.93797173
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.93777364
78E2F1_21310950_ChIP-Seq_MCF-7_Human0.93777170
79TAF2_19829295_ChIP-Seq_ESCs_Human0.92691388
80FOXP1_21924763_ChIP-Seq_HESCs_Human0.90527125
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89784552
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89536602
83CTCF_20526341_ChIP-Seq_ESCs_Human0.89161249
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88859788
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87841577
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86978187
87EWS_26573619_Chip-Seq_HEK293_Human0.86420585
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85646056
89CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85292961
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85015168
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84599220
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82849169
93FOXA1_25329375_ChIP-Seq_VCAP_Human0.82402139
94FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82402139
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82074100
96NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80691039
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80519399
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80151005
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79543291
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.77119674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.18515400
2MP0003646_muscle_fatigue3.90245343
3MP0009379_abnormal_foot_pigmentation3.74372163
4MP0008877_abnormal_DNA_methylation3.54889201
5MP0002102_abnormal_ear_morphology3.10616506
6MP0008875_abnormal_xenobiotic_pharmacok3.01617723
7MP0003693_abnormal_embryo_hatching2.49743314
8MP0005645_abnormal_hypothalamus_physiol2.26667403
9MP0006276_abnormal_autonomic_nervous2.16456117
10MP0003878_abnormal_ear_physiology2.15405091
11MP0005377_hearing/vestibular/ear_phenot2.15405091
12MP0002138_abnormal_hepatobiliary_system2.11509903
13MP0001529_abnormal_vocalization2.05532516
14MP0004142_abnormal_muscle_tone2.04716422
15MP0003787_abnormal_imprinting2.04184668
16MP0005084_abnormal_gallbladder_morpholo1.98512452
17MP0001919_abnormal_reproductive_system1.97122058
18MP0003122_maternal_imprinting1.91199857
19MP0005394_taste/olfaction_phenotype1.83336284
20MP0005499_abnormal_olfactory_system1.83336284
21MP0008789_abnormal_olfactory_epithelium1.82944982
22MP0008058_abnormal_DNA_repair1.76618890
23MP0003786_premature_aging1.75218590
24MP0006072_abnormal_retinal_apoptosis1.68944484
25MP0008872_abnormal_physiological_respon1.68146536
26MP0002653_abnormal_ependyma_morphology1.57330707
27MP0005389_reproductive_system_phenotype1.57212352
28MP0004742_abnormal_vestibular_system1.50724647
29MP0003195_calcinosis1.50629375
30MP0003186_abnormal_redox_activity1.47924364
31MP0004957_abnormal_blastocyst_morpholog1.46455219
32MP0006036_abnormal_mitochondrial_physio1.46076266
33MP0003718_maternal_effect1.45313549
34MP0002210_abnormal_sex_determination1.43684147
35MP0001293_anophthalmia1.43243255
36MP0005551_abnormal_eye_electrophysiolog1.34782616
37MP0001984_abnormal_olfaction1.34263092
38MP0003567_abnormal_fetal_cardiomyocyte1.32806058
39MP0001348_abnormal_lacrimal_gland1.27500653
40MP0001929_abnormal_gametogenesis1.26659086
41MP0005360_urolithiasis1.22556817
42MP0000049_abnormal_middle_ear1.18985220
43MP0009046_muscle_twitch1.18090326
44MP0002163_abnormal_gland_morphology1.17997979
45MP0001853_heart_inflammation1.14978174
46MP0002837_dystrophic_cardiac_calcinosis1.14848313
47MP0001905_abnormal_dopamine_level1.12524354
48MP0002736_abnormal_nociception_after1.11043364
49MP0010094_abnormal_chromosome_stability1.11033955
50MP0001502_abnormal_circadian_rhythm1.10853954
51MP0004885_abnormal_endolymph1.09258575
52MP0002557_abnormal_social/conspecific_i1.07572534
53MP0000465_gastrointestinal_hemorrhage1.05258967
54MP0001485_abnormal_pinna_reflex1.05144465
55MP0003121_genomic_imprinting1.05017848
56MP0010386_abnormal_urinary_bladder1.02258721
57MP0001661_extended_life_span1.00524727
58MP0001968_abnormal_touch/_nociception0.99687891
59MP0005365_abnormal_bile_salt0.99505237
60MP0002160_abnormal_reproductive_system0.98808011
61MP0000653_abnormal_sex_gland0.98805758
62MP0003119_abnormal_digestive_system0.97512137
63MP0001145_abnormal_male_reproductive0.96937597
64MP0005085_abnormal_gallbladder_physiolo0.96498251
65MP0004145_abnormal_muscle_electrophysio0.95479557
66MP0002876_abnormal_thyroid_physiology0.93024019
67MP0003938_abnormal_ear_development0.92978138
68MP0005410_abnormal_fertilization0.91807545
69MP0003698_abnormal_male_reproductive0.88825890
70MP0009745_abnormal_behavioral_response0.88313247
71MP0001119_abnormal_female_reproductive0.88266733
72MP0005636_abnormal_mineral_homeostasis0.87418580
73MP0002277_abnormal_respiratory_mucosa0.87366775
74MP0002272_abnormal_nervous_system0.86965826
75MP0005174_abnormal_tail_pigmentation0.84256321
76MP0006035_abnormal_mitochondrial_morpho0.83734826
77MP0008932_abnormal_embryonic_tissue0.82772852
78MP0005332_abnormal_amino_acid0.82273718
79MP0001835_abnormal_antigen_presentation0.81287002
80MP0008995_early_reproductive_senescence0.80607771
81MP0001873_stomach_inflammation0.80091620
82MP0002733_abnormal_thermal_nociception0.80002913
83MP0009764_decreased_sensitivity_to0.79744224
84MP0005167_abnormal_blood-brain_barrier0.79528079
85MP0003123_paternal_imprinting0.79000722
86MP0004019_abnormal_vitamin_homeostasis0.78147509
87MP0001501_abnormal_sleep_pattern0.77980737
88MP0003252_abnormal_bile_duct0.77708631
89MP0003806_abnormal_nucleotide_metabolis0.76635302
90MP0005195_abnormal_posterior_eye0.76040418
91MP0001188_hyperpigmentation0.75829256
92MP0005253_abnormal_eye_physiology0.73936724
93MP0000631_abnormal_neuroendocrine_gland0.73008536
94MP0000015_abnormal_ear_pigmentation0.72800210
95MP0005646_abnormal_pituitary_gland0.72387988
96MP0000026_abnormal_inner_ear0.70381269
97MP0003937_abnormal_limbs/digits/tail_de0.69500098
98MP0008775_abnormal_heart_ventricle0.68395355
99MP0004133_heterotaxia0.68357261
100MP0002938_white_spotting0.67919460

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.29900418
2Abnormal mitochondria in muscle tissue (HP:0008316)4.72922698
3Acute encephalopathy (HP:0006846)4.55804571
43-Methylglutaconic aciduria (HP:0003535)4.36605427
5Progressive macrocephaly (HP:0004481)4.29858749
6Reticulocytopenia (HP:0001896)4.25794850
7Increased CSF lactate (HP:0002490)4.09791540
8Mitochondrial inheritance (HP:0001427)4.08957671
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.94988131
10Microvesicular hepatic steatosis (HP:0001414)3.66240087
11Cerebral edema (HP:0002181)3.47230954
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.36705746
13Increased hepatocellular lipid droplets (HP:0006565)3.34912792
14Lipid accumulation in hepatocytes (HP:0006561)3.25232542
15Increased serum lactate (HP:0002151)3.12362443
16Renal Fanconi syndrome (HP:0001994)3.05869352
17Increased intramyocellular lipid droplets (HP:0012240)2.95726793
18Molar tooth sign on MRI (HP:0002419)2.95129278
19Abnormality of midbrain morphology (HP:0002418)2.95129278
20Abnormality of cells of the erythroid lineage (HP:0012130)2.94662472
21Abnormal rod and cone electroretinograms (HP:0008323)2.90634467
22Hepatic necrosis (HP:0002605)2.85632086
23Abnormal biliary tract physiology (HP:0012439)2.82263883
24Bile duct proliferation (HP:0001408)2.82263883
25Type II lissencephaly (HP:0007260)2.78154117
26Macrocytic anemia (HP:0001972)2.74992679
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74210760
28Increased serum pyruvate (HP:0003542)2.73528922
29Testicular atrophy (HP:0000029)2.72955820
30Optic disc pallor (HP:0000543)2.67730503
31Abnormal number of erythroid precursors (HP:0012131)2.65163218
32Renovascular hypertension (HP:0100817)2.64400184
33Pendular nystagmus (HP:0012043)2.62280918
34Exercise intolerance (HP:0003546)2.61112866
35Hepatocellular necrosis (HP:0001404)2.60492555
36Lactic acidosis (HP:0003128)2.58266404
37Increased muscle lipid content (HP:0009058)2.57705255
38Methylmalonic aciduria (HP:0012120)2.52351465
39Nephronophthisis (HP:0000090)2.50146963
40Colon cancer (HP:0003003)2.47853856
41Abnormality of urine glucose concentration (HP:0011016)2.47728729
42Glycosuria (HP:0003076)2.47728729
43Polydipsia (HP:0001959)2.44918002
44Abnormal drinking behavior (HP:0030082)2.44918002
45Severe visual impairment (HP:0001141)2.43899848
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42719043
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42719043
48Absent thumb (HP:0009777)2.41993790
49Abnormality of the labia minora (HP:0012880)2.39630015
50Respiratory failure (HP:0002878)2.33462622
51Leukodystrophy (HP:0002415)2.32817089
52Abnormality of the renal cortex (HP:0011035)2.30709041
53Lethargy (HP:0001254)2.29428618
54Abnormality of glycolysis (HP:0004366)2.28206910
55Methylmalonic acidemia (HP:0002912)2.26559731
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26279362
57Dicarboxylic aciduria (HP:0003215)2.26279362
58Generalized aminoaciduria (HP:0002909)2.23698353
59Pachygyria (HP:0001302)2.22661906
60Overriding aorta (HP:0002623)2.19984012
61Hyperglycinemia (HP:0002154)2.18799054
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17591280
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17324744
64Abnormality of alanine metabolism (HP:0010916)2.17324744
65Hyperalaninemia (HP:0003348)2.17324744
66Congenital stationary night blindness (HP:0007642)2.14734738
67Respiratory difficulties (HP:0002880)2.14257622
68Elfin facies (HP:0004428)2.12717338
69Agitation (HP:0000713)2.12679557
70Pancreatic cysts (HP:0001737)2.11308938
71Pallor (HP:0000980)2.09121361
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07777437
73Exertional dyspnea (HP:0002875)2.06869390
74Abnormality of the renal medulla (HP:0100957)1.97325662
75Tubular atrophy (HP:0000092)1.92921482
76Lissencephaly (HP:0001339)1.91797612
77Renal cortical cysts (HP:0000803)1.90114190
78Confusion (HP:0001289)1.89307643
79Hypoglycemic coma (HP:0001325)1.85374334
80Hypoplasia of the radius (HP:0002984)1.85137674
81Polyuria (HP:0000103)1.84907036
82Abolished electroretinogram (ERG) (HP:0000550)1.82988448
83Abnormality of the carotid arteries (HP:0005344)1.81257993
84Chromsome breakage (HP:0040012)1.80603871
85Pancytopenia (HP:0001876)1.77397064
86Horseshoe kidney (HP:0000085)1.75977749
87Opisthotonus (HP:0002179)1.74816185
88Abnormality of the diencephalon (HP:0010662)1.74268852
89Constricted visual fields (HP:0001133)1.74222036
90Pancreatic fibrosis (HP:0100732)1.74076695
91Ependymoma (HP:0002888)1.73695657
92Hypomagnesemia (HP:0002917)1.73324882
93Degeneration of anterior horn cells (HP:0002398)1.72778268
94Abnormality of the anterior horn cell (HP:0006802)1.72778268
95Cerebral hypomyelination (HP:0006808)1.72617933
96Hypoplasia of the pons (HP:0012110)1.70937837
97X-linked dominant inheritance (HP:0001423)1.70470388
98Congenital, generalized hypertrichosis (HP:0004540)1.69434833
99Oligodactyly (HP:0012165)1.69366002
100Ragged-red muscle fibers (HP:0003200)1.68826893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.27858382
2LIMK13.63641570
3ZAK3.36255848
4TRIM282.80772131
5CDC72.79409605
6SRPK12.72239026
7BCKDK2.49942877
8TIE12.48249697
9BUB12.37272415
10STK162.37010491
11BMPR1B2.33082689
12TSSK62.28340134
13PBK2.16749984
14ADRBK22.16211789
15WNK42.09773676
16GRK12.09633950
17CDK81.92995024
18NME21.92717215
19CDK191.88772546
20TXK1.84077648
21VRK21.67436361
22BRSK11.58880069
23DYRK21.55188201
24VRK11.47460401
25PDK21.47354847
26EIF2AK11.46229736
27CAMKK21.42985344
28MST41.41420271
29AURKA1.38649669
30RPS6KA51.36333505
31PINK11.36184049
32STK391.29883349
33NME11.26330096
34NEK11.23147756
35PLK11.10483699
36CSNK1G21.07869199
37CSNK1G31.06671560
38ATR1.05581242
39MAP4K11.00621719
40NUAK11.00097226
41CDC42BPA0.94343404
42ITK0.90806532
43FRK0.89885842
44PLK30.89433945
45CSNK1G10.88369604
46ICK0.87060344
47CSNK1A1L0.86446314
48TEC0.85542402
49MAP3K110.84722608
50ALK0.80937466
51INSRR0.80412203
52OXSR10.76677838
53CHEK10.76631835
54CSNK2A20.75191947
55AURKB0.73795697
56CAMK1D0.72482813
57EPHB20.68495561
58PRKCG0.68406678
59TNIK0.66755264
60EIF2AK30.64679134
61CAMKK10.62904059
62BCR0.61464396
63NTRK20.59242335
64AKT20.57240655
65MAP4K20.56826118
66CSNK1E0.56503701
67PAK40.55867444
68CSNK2A10.53666147
69CDK70.51737167
70PIK3CA0.50445077
71CHEK20.50326008
72FES0.50055931
73MKNK20.49229751
74PRKCQ0.46693424
75ACVR1B0.44391447
76KDR0.41721208
77WNK30.40841551
78CLK10.40728108
79CCNB10.40172306
80PAK30.38102523
81CAMK10.37904395
82MAPK110.37107210
83DAPK30.37075862
84STK40.35528415
85PTK60.34582417
86TAF10.33298770
87PRKCI0.33111952
88EIF2AK20.32585763
89ATM0.32208367
90IRAK40.30934014
91CSNK1D0.29408448
92MAP3K90.29102205
93IKBKB0.29080002
94CDK10.28873600
95PHKG20.28862025
96PHKG10.28862025
97MAP2K20.28389045
98ABL20.27825350
99PRKACA0.27780170
100PAK10.27408426

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.21137224
2Proteasome_Homo sapiens_hsa030503.91456038
3Oxidative phosphorylation_Homo sapiens_hsa001903.63921032
4RNA polymerase_Homo sapiens_hsa030203.35061791
5Parkinsons disease_Homo sapiens_hsa050123.11161434
6Protein export_Homo sapiens_hsa030603.04482842
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50742363
8Huntingtons disease_Homo sapiens_hsa050162.21763666
9DNA replication_Homo sapiens_hsa030302.09765390
10Sulfur metabolism_Homo sapiens_hsa009202.04269753
11Systemic lupus erythematosus_Homo sapiens_hsa053221.89417354
12Pyrimidine metabolism_Homo sapiens_hsa002401.88199048
13Sulfur relay system_Homo sapiens_hsa041221.85042620
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80697010
15Alzheimers disease_Homo sapiens_hsa050101.80031682
16RNA degradation_Homo sapiens_hsa030181.75767549
17Nitrogen metabolism_Homo sapiens_hsa009101.75696031
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72755043
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68396629
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68317437
21Spliceosome_Homo sapiens_hsa030401.68217490
22Cardiac muscle contraction_Homo sapiens_hsa042601.60232286
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49849367
24Homologous recombination_Homo sapiens_hsa034401.49591878
25Mismatch repair_Homo sapiens_hsa034301.49060619
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48385163
27Fanconi anemia pathway_Homo sapiens_hsa034601.47915805
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46177502
29One carbon pool by folate_Homo sapiens_hsa006701.43871049
30Basal transcription factors_Homo sapiens_hsa030221.41004259
31RNA transport_Homo sapiens_hsa030131.39530527
32Linoleic acid metabolism_Homo sapiens_hsa005911.32333957
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30900983
34Peroxisome_Homo sapiens_hsa041461.30861173
35Base excision repair_Homo sapiens_hsa034101.29916238
36Nucleotide excision repair_Homo sapiens_hsa034201.27733907
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27540061
38Phototransduction_Homo sapiens_hsa047441.25248509
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14907420
40Alcoholism_Homo sapiens_hsa050341.13986461
41Propanoate metabolism_Homo sapiens_hsa006401.06482906
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.04355368
43Allograft rejection_Homo sapiens_hsa053301.02333412
44Tryptophan metabolism_Homo sapiens_hsa003800.98862009
45Fat digestion and absorption_Homo sapiens_hsa049750.98778204
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98496336
47Autoimmune thyroid disease_Homo sapiens_hsa053200.98418752
48Asthma_Homo sapiens_hsa053100.96998087
49Purine metabolism_Homo sapiens_hsa002300.95956323
50Steroid biosynthesis_Homo sapiens_hsa001000.94665162
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.90538831
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90535749
53Pyruvate metabolism_Homo sapiens_hsa006200.88243153
54Type I diabetes mellitus_Homo sapiens_hsa049400.84299685
55Glutathione metabolism_Homo sapiens_hsa004800.82639473
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.79407010
57Ether lipid metabolism_Homo sapiens_hsa005650.76762717
58Metabolic pathways_Homo sapiens_hsa011000.74489581
59Collecting duct acid secretion_Homo sapiens_hsa049660.72166024
60Carbon metabolism_Homo sapiens_hsa012000.71143230
61beta-Alanine metabolism_Homo sapiens_hsa004100.70461395
62Selenocompound metabolism_Homo sapiens_hsa004500.69348801
63Arachidonic acid metabolism_Homo sapiens_hsa005900.69320241
64Folate biosynthesis_Homo sapiens_hsa007900.69042197
65Arginine and proline metabolism_Homo sapiens_hsa003300.66604991
66Fatty acid degradation_Homo sapiens_hsa000710.63538995
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61246729
68Non-homologous end-joining_Homo sapiens_hsa034500.61198156
69Fatty acid elongation_Homo sapiens_hsa000620.60807004
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55806972
71Arginine biosynthesis_Homo sapiens_hsa002200.54123419
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53989952
73Caffeine metabolism_Homo sapiens_hsa002320.53841148
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53769794
75Cell cycle_Homo sapiens_hsa041100.53093143
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.51010253
77Butanoate metabolism_Homo sapiens_hsa006500.47871786
78Vibrio cholerae infection_Homo sapiens_hsa051100.46702496
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45923893
80Biosynthesis of amino acids_Homo sapiens_hsa012300.45531456
81p53 signaling pathway_Homo sapiens_hsa041150.43813306
82Regulation of autophagy_Homo sapiens_hsa041400.42949771
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41539199
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39328404
85Graft-versus-host disease_Homo sapiens_hsa053320.38847029
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38112641
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32720194
88Nicotine addiction_Homo sapiens_hsa050330.31363626
89Primary immunodeficiency_Homo sapiens_hsa053400.30128891
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29954832
91Chemical carcinogenesis_Homo sapiens_hsa052040.29923443
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27765228
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27759226
94Synaptic vesicle cycle_Homo sapiens_hsa047210.25478525
95Tyrosine metabolism_Homo sapiens_hsa003500.24942329
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24863636
97Vitamin B6 metabolism_Homo sapiens_hsa007500.24758300
98Hematopoietic cell lineage_Homo sapiens_hsa046400.24427426
99Ovarian steroidogenesis_Homo sapiens_hsa049130.24324189
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22786487

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