RPS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* ribosomal small subunit assembly (GO:0000028)7.34420904
2* viral transcription (GO:0019083)7.26650501
3* translational termination (GO:0006415)7.03523893
4* translational elongation (GO:0006414)6.16083958
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.07957101
6* ribosomal small subunit biogenesis (GO:0042274)6.01219149
7maturation of SSU-rRNA (GO:0030490)6.00187242
8* cotranslational protein targeting to membrane (GO:0006613)5.94847608
9* protein targeting to ER (GO:0045047)5.93328871
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.65631687
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.64586439
12* protein localization to endoplasmic reticulum (GO:0070972)5.56168159
13* viral life cycle (GO:0019058)5.44738089
14* cellular protein complex disassembly (GO:0043624)5.44691604
15* translational initiation (GO:0006413)5.42803167
16ribosomal large subunit biogenesis (GO:0042273)5.16726238
17* protein complex disassembly (GO:0043241)4.84818243
18* macromolecular complex disassembly (GO:0032984)4.54130444
19formation of translation preinitiation complex (GO:0001731)4.40921673
20* nuclear-transcribed mRNA catabolic process (GO:0000956)4.28643904
21DNA strand elongation involved in DNA replication (GO:0006271)4.17495573
22* ribonucleoprotein complex biogenesis (GO:0022613)4.14849781
23telomere maintenance via semi-conservative replication (GO:0032201)4.09738260
24* mRNA catabolic process (GO:0006402)4.07950004
25DNA strand elongation (GO:0022616)4.01124664
26* translation (GO:0006412)3.97818052
27DNA unwinding involved in DNA replication (GO:0006268)3.90865957
28* protein targeting to membrane (GO:0006612)3.89258267
29* RNA catabolic process (GO:0006401)3.88431688
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78205366
31DNA deamination (GO:0045006)3.76030535
32DNA replication initiation (GO:0006270)3.74804269
33telomere maintenance via recombination (GO:0000722)3.64972992
34* rRNA processing (GO:0006364)3.51249416
35mitotic recombination (GO:0006312)3.44276301
36* rRNA metabolic process (GO:0016072)3.39374900
37* protein targeting (GO:0006605)3.35695691
38telomere maintenance via telomere lengthening (GO:0010833)3.31218417
39nucleobase biosynthetic process (GO:0046112)3.31060675
40ATP synthesis coupled proton transport (GO:0015986)3.25971760
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25971760
42IMP biosynthetic process (GO:0006188)3.24765633
43protein localization to kinetochore (GO:0034501)3.17019679
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.16241746
45ribosome biogenesis (GO:0042254)3.14999012
46CENP-A containing nucleosome assembly (GO:0034080)3.09630062
47folic acid-containing compound biosynthetic process (GO:0009396)3.05446739
48* cellular component biogenesis (GO:0044085)3.03259202
49chromatin remodeling at centromere (GO:0031055)3.01428913
50DNA replication checkpoint (GO:0000076)2.99396271
51purine nucleobase biosynthetic process (GO:0009113)2.97653031
52IMP metabolic process (GO:0046040)2.96670416
53rRNA modification (GO:0000154)2.94667456
54mitotic nuclear envelope disassembly (GO:0007077)2.89524456
55negative regulation of RNA splicing (GO:0033119)2.89209418
56establishment of integrated proviral latency (GO:0075713)2.88359621
57DNA replication-independent nucleosome organization (GO:0034724)2.86627401
58DNA replication-independent nucleosome assembly (GO:0006336)2.86627401
59DNA replication-dependent nucleosome assembly (GO:0006335)2.85736031
60DNA replication-dependent nucleosome organization (GO:0034723)2.85736031
61pseudouridine synthesis (GO:0001522)2.85504469
62regulation of translational fidelity (GO:0006450)2.84267421
63* ribonucleoprotein complex assembly (GO:0022618)2.83973624
64spliceosomal snRNP assembly (GO:0000387)2.82765654
65* protein localization to membrane (GO:0072657)2.82407169
66ribosome assembly (GO:0042255)2.81008559
67establishment of viral latency (GO:0019043)2.79208003
68negative regulation of DNA repair (GO:0045738)2.77891871
69* gene expression (GO:0010467)2.76947078
70ncRNA 3-end processing (GO:0043628)2.74943433
71oxidative phosphorylation (GO:0006119)2.74540217
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74087798
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73902071
74nuclear pore complex assembly (GO:0051292)2.72119901
75viral mRNA export from host cell nucleus (GO:0046784)2.71835774
76chaperone-mediated protein transport (GO:0072321)2.71500569
77regulation of mitochondrial translation (GO:0070129)2.70937255
78protein localization to chromosome, centromeric region (GO:0071459)2.69570595
79telomere maintenance (GO:0000723)2.68414952
80* ribonucleoprotein complex subunit organization (GO:0071826)2.68167471
81transcription-coupled nucleotide-excision repair (GO:0006283)2.68140438
82telomere organization (GO:0032200)2.67495539
83negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67193161
84establishment of protein localization to mitochondrial membrane (GO:0090151)2.65610578
85mitotic chromosome condensation (GO:0007076)2.64027370
86kinetochore organization (GO:0051383)2.63678539
87nuclear envelope disassembly (GO:0051081)2.63313476
88membrane disassembly (GO:0030397)2.63313476
89antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.63051520
90antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.63051520
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.62577385
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60188069
93* ncRNA processing (GO:0034470)2.59572871
94DNA ligation (GO:0006266)2.59483874
95regulation of histone H3-K9 methylation (GO:0051570)2.59205957
96RNA splicing, via transesterification reactions (GO:0000375)2.59158916
97mRNA splicing, via spliceosome (GO:0000398)2.59090462
98RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.59090462
99transcription from mitochondrial promoter (GO:0006390)2.58586038
100* establishment of protein localization to membrane (GO:0090150)2.58304865
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.57023764
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55945748
103histone mRNA metabolic process (GO:0008334)2.55214964
104anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55187109
105positive regulation of histone H3-K4 methylation (GO:0051571)2.54033247
106nuclear pore organization (GO:0006999)2.53772784
107DNA duplex unwinding (GO:0032508)2.53475809
108negative regulation of ligase activity (GO:0051352)2.53303520
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53303520
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.51992648
111DNA geometric change (GO:0032392)2.51569348
112spliceosomal complex assembly (GO:0000245)2.51537112
113regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51356823
114mitotic metaphase plate congression (GO:0007080)2.50590766
115* establishment of protein localization to organelle (GO:0072594)2.50456375
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49928452
117signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.49928452
118negative regulation of translational initiation (GO:0045947)2.49017850
119regulation of translational initiation (GO:0006446)2.48959506
120termination of RNA polymerase II transcription (GO:0006369)2.47678786
121* protein localization to organelle (GO:0033365)2.47620742
122maturation of 5.8S rRNA (GO:0000460)2.47403003
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.47213955
124DNA topological change (GO:0006265)2.47098153
125* ncRNA metabolic process (GO:0034660)2.46889501
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.46875027
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.46875027
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.46875027
129termination of RNA polymerase III transcription (GO:0006386)2.45576152
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.45576152
131nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45519014
132rRNA methylation (GO:0031167)2.39356147
133* cellular component disassembly (GO:0022411)2.38851058
134protein targeting to mitochondrion (GO:0006626)2.38284521
135DNA-templated transcription, termination (GO:0006353)2.38127132
136aerobic respiration (GO:0009060)2.37984583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.45251148
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.35531407
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83861768
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14554076
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04665513
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.96343062
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.91268087
8* GABP_17652178_ChIP-ChIP_JURKAT_Human2.82035624
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77517063
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68962743
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68615835
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66968756
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.66641252
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63597079
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49861634
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48035366
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46670656
18* XRN2_22483619_ChIP-Seq_HELA_Human2.41002944
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39147055
20* VDR_23849224_ChIP-Seq_CD4+_Human2.30751401
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25058021
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22630992
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17599443
24* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10165354
25FOXP3_21729870_ChIP-Seq_TREG_Human2.05244899
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.04383408
27MYC_22102868_ChIP-Seq_BL_Human1.99139735
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98096001
29* TTF2_22483619_ChIP-Seq_HELA_Human1.91704398
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88091321
31* DCP1A_22483619_ChIP-Seq_HELA_Human1.86753592
32ELK1_19687146_ChIP-ChIP_HELA_Human1.86284928
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76519085
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76026037
35* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73512989
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70321221
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69435034
38GABP_19822575_ChIP-Seq_HepG2_Human1.68293542
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.68145773
40CIITA_25753668_ChIP-Seq_RAJI_Human1.67077287
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63186007
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60503077
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58983212
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56356789
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56205347
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53688362
47AR_21909140_ChIP-Seq_LNCAP_Human1.52416753
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52189172
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49599722
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49176068
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49172705
52VDR_21846776_ChIP-Seq_THP-1_Human1.47808441
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47555702
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45812656
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42071707
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40130863
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36693541
58* SPI1_23547873_ChIP-Seq_NB4_Human1.35527873
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34269060
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.34191750
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.31829859
62KDM5A_27292631_Chip-Seq_BREAST_Human1.30237935
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.26992591
64GATA1_22025678_ChIP-Seq_K562_Human1.26644053
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26642751
66SCL_19346495_ChIP-Seq_HPC-7_Human1.25590977
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.23789042
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16190267
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15549689
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13224167
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12494352
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11827458
73TFEB_21752829_ChIP-Seq_HELA_Human1.11653440
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10135586
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08681974
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07768900
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07117454
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04829904
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.04771207
80MYB_26560356_Chip-Seq_TH2_Human1.04467628
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04376391
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03280346
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02139135
84* ELK1_22589737_ChIP-Seq_MCF10A_Human1.01826455
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01762499
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01204009
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00272539
88* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00018870
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99614030
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98848278
91MYC_18940864_ChIP-ChIP_HL60_Human0.98630031
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98127857
93MAF_26560356_Chip-Seq_TH1_Human0.97749974
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97417966
95* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97274587
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95119003
97UTX_26944678_Chip-Seq_JUKART_Human0.95094408
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95071770
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94979644
100MYB_26560356_Chip-Seq_TH1_Human0.94719142
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94098371
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93885257
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93868669
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93241398
105SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93010108
106RUNX1_22412390_ChIP-Seq_EML_Mouse0.91675771
107ZNF263_19887448_ChIP-Seq_K562_Human0.90083765
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89330085
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87134664
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82554836
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81603307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.22015586
2MP0010094_abnormal_chromosome_stability3.56142863
3MP0004957_abnormal_blastocyst_morpholog3.49928920
4MP0002396_abnormal_hematopoietic_system3.30432639
5MP0003111_abnormal_nucleus_morphology3.07556304
6* MP0003077_abnormal_cell_cycle3.04009185
7MP0008057_abnormal_DNA_replication3.03146296
8MP0008058_abnormal_DNA_repair2.66379971
9MP0009379_abnormal_foot_pigmentation2.50947737
10MP0008007_abnormal_cellular_replicative2.50366156
11MP0003763_abnormal_thymus_physiology2.33855187
12MP0002009_preneoplasia2.28969099
13MP0004808_abnormal_hematopoietic_stem2.20508545
14MP0001835_abnormal_antigen_presentation2.13927769
15MP0000490_abnormal_crypts_of2.07873932
16MP0010352_gastrointestinal_tract_polyps2.02548463
17MP0003806_abnormal_nucleotide_metabolis1.99595425
18MP0006292_abnormal_olfactory_placode1.97556338
19MP0009333_abnormal_splenocyte_physiolog1.90817452
20MP0002398_abnormal_bone_marrow1.83039331
21MP0006054_spinal_hemorrhage1.80273798
22MP0003786_premature_aging1.79468544
23MP0008932_abnormal_embryonic_tissue1.77339047
24MP0005397_hematopoietic_system_phenotyp1.73446186
25MP0001545_abnormal_hematopoietic_system1.73446186
26MP0000685_abnormal_immune_system1.73040173
27MP0000350_abnormal_cell_proliferation1.68876651
28MP0005671_abnormal_response_to1.64576723
29MP0008995_early_reproductive_senescence1.64086807
30MP0002166_altered_tumor_susceptibility1.63902927
31MP0001730_embryonic_growth_arrest1.63430838
32MP0003123_paternal_imprinting1.62040734
33MP0002722_abnormal_immune_system1.59870960
34MP0001800_abnormal_humoral_immune1.59780993
35MP0000703_abnormal_thymus_morphology1.57727543
36MP0000689_abnormal_spleen_morphology1.55761139
37MP0002019_abnormal_tumor_incidence1.51622751
38MP0002420_abnormal_adaptive_immunity1.44480341
39MP0002429_abnormal_blood_cell1.42431892
40MP0000716_abnormal_immune_system1.42007086
41MP0001819_abnormal_immune_cell1.41712903
42MP0002452_abnormal_antigen_presenting1.40582132
43MP0000465_gastrointestinal_hemorrhage1.39279310
44MP0009697_abnormal_copulation1.39271279
45MP0010307_abnormal_tumor_latency1.38828146
46MP0009785_altered_susceptibility_to1.36749787
47MP0002006_tumorigenesis1.36565445
48MP0001873_stomach_inflammation1.33516691
49MP0003567_abnormal_fetal_cardiomyocyte1.32724215
50MP0000313_abnormal_cell_death1.32456687
51MP0005174_abnormal_tail_pigmentation1.30929178
52MP0002723_abnormal_immune_serum1.29923419
53MP0001853_heart_inflammation1.29791938
54MP0002405_respiratory_system_inflammati1.24436069
55MP0002095_abnormal_skin_pigmentation1.22770613
56MP0005075_abnormal_melanosome_morpholog1.22471416
57MP0005025_abnormal_response_to1.21455918
58MP0005000_abnormal_immune_tolerance1.19916913
59MP0006036_abnormal_mitochondrial_physio1.19677868
60MP0010155_abnormal_intestine_physiology1.19547786
61MP0002080_prenatal_lethality1.18633865
62MP0001697_abnormal_embryo_size1.18226272
63MP0002163_abnormal_gland_morphology1.16288883
64MP0003436_decreased_susceptibility_to1.14642615
65MP0000858_altered_metastatic_potential1.13257010
66MP0001672_abnormal_embryogenesis/_devel1.09791873
67MP0005380_embryogenesis_phenotype1.09791873
68MP0002132_abnormal_respiratory_system1.08130030
69MP0005464_abnormal_platelet_physiology1.05687368
70MP0002148_abnormal_hypersensitivity_rea1.05373178
71MP0002796_impaired_skin_barrier1.04778299
72MP0003984_embryonic_growth_retardation1.02781913
73MP0004197_abnormal_fetal_growth/weight/1.02129810
74MP0002086_abnormal_extraembryonic_tissu1.01368240
75MP0002160_abnormal_reproductive_system1.01266282
76MP0002088_abnormal_embryonic_growth/wei1.00825480
77MP0003866_abnormal_defecation1.00017145
78MP0006035_abnormal_mitochondrial_morpho0.99204857
79MP0009278_abnormal_bone_marrow0.98745497
80MP0004147_increased_porphyrin_level0.98563337
81MP0001790_abnormal_immune_system0.97932593
82MP0005387_immune_system_phenotype0.97932593
83MP0001145_abnormal_male_reproductive0.97764052
84MP0003186_abnormal_redox_activity0.96024958
85MP0005023_abnormal_wound_healing0.93620579
86MP0001929_abnormal_gametogenesis0.90944214
87MP0002085_abnormal_embryonic_tissue0.90703960
88MP0002084_abnormal_developmental_patter0.90470663
89MP0004185_abnormal_adipocyte_glucose0.90189075
90MP0008877_abnormal_DNA_methylation0.89462795
91MP0001188_hyperpigmentation0.88069206
92MP0002938_white_spotting0.86797060
93MP0001293_anophthalmia0.85428458
94MP0000372_irregular_coat_pigmentation0.83980578
95MP0003315_abnormal_perineum_morphology0.82819572
96MP0001881_abnormal_mammary_gland0.81348172
97MP0003121_genomic_imprinting0.81234975
98MP0005220_abnormal_exocrine_pancreas0.79917211
99MP0000653_abnormal_sex_gland0.79395377
100MP0002419_abnormal_innate_immunity0.78993604
101MP0001845_abnormal_inflammatory_respons0.78072786
102MP0000477_abnormal_intestine_morphology0.76441868
103MP0004947_skin_inflammation0.72715016
104MP0009672_abnormal_birth_weight0.72105835
105MP0005389_reproductive_system_phenotype0.68563414
106MP0010030_abnormal_orbit_morphology0.66736990
107MP0003941_abnormal_skin_development0.66405488
108MP0003448_altered_tumor_morphology0.66296344
109MP0001286_abnormal_eye_development0.65925523
110MP0005076_abnormal_cell_differentiation0.65449620
111MP0002877_abnormal_melanocyte_morpholog0.63724698
112MP0005501_abnormal_skin_physiology0.63115216
113MP0001119_abnormal_female_reproductive0.62074061
114MP0003566_abnormal_cell_adhesion0.62051920
115MP0002933_joint_inflammation0.61960598
116MP0000537_abnormal_urethra_morphology0.60745411
117MP0003724_increased_susceptibility_to0.60743721
118MP0003943_abnormal_hepatobiliary_system0.58862915
119MP0002210_abnormal_sex_determination0.58048291
120* MP0000358_abnormal_cell_content/0.57999066
121MP0003718_maternal_effect0.57502879
122MP0001915_intracranial_hemorrhage0.57417885
123* MP0005384_cellular_phenotype0.55811621

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.35475163
2Abnormal number of erythroid precursors (HP:0012131)6.60383160
3Reticulocytopenia (HP:0001896)6.57305657
4Macrocytic anemia (HP:0001972)4.56126855
5Pallor (HP:0000980)4.50632041
6Thrombocytosis (HP:0001894)4.48899219
7Aplastic anemia (HP:0001915)3.87785614
8Colon cancer (HP:0003003)3.59810988
911 pairs of ribs (HP:0000878)3.58597652
10Increased hepatocellular lipid droplets (HP:0006565)3.49494722
11IgM deficiency (HP:0002850)3.41889905
12Birth length less than 3rd percentile (HP:0003561)3.27299144
13Lipid accumulation in hepatocytes (HP:0006561)3.10903783
14Oral leukoplakia (HP:0002745)3.00458099
15Acute lymphatic leukemia (HP:0006721)2.88582857
16Respiratory difficulties (HP:0002880)2.76691145
17Myelodysplasia (HP:0002863)2.67131208
18Selective tooth agenesis (HP:0001592)2.65124977
19Absent thumb (HP:0009777)2.65021388
20Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56688993
21Increased intramyocellular lipid droplets (HP:0012240)2.55102670
22Chronic otitis media (HP:0000389)2.54579816
23Recurrent bronchitis (HP:0002837)2.47359276
24Acute necrotizing encephalopathy (HP:0006965)2.46790099
25Elevated erythrocyte sedimentation rate (HP:0003565)2.46401358
26Mitochondrial inheritance (HP:0001427)2.42442547
27Petechiae (HP:0000967)2.41165205
28Increased CSF lactate (HP:0002490)2.40274106
29Lymphoma (HP:0002665)2.38689686
30Basal cell carcinoma (HP:0002671)2.38034011
31Abnormal mitochondria in muscle tissue (HP:0008316)2.37909331
32Rough bone trabeculation (HP:0100670)2.36783989
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34016583
34Amaurosis fugax (HP:0100576)2.33071326
35Abnormality of reticulocytes (HP:0004312)2.31706391
36Short middle phalanx of the 5th finger (HP:0004220)2.30783552
37Acute encephalopathy (HP:0006846)2.29929384
38Abnormality of T cell physiology (HP:0011840)2.27533455
39Renal Fanconi syndrome (HP:0001994)2.26587519
403-Methylglutaconic aciduria (HP:0003535)2.25028415
41Carpal bone hypoplasia (HP:0001498)2.24880841
42Abnormality of T cells (HP:0002843)2.23615376
43Microretrognathia (HP:0000308)2.21473713
44Chromsome breakage (HP:0040012)2.21308208
45Poikiloderma (HP:0001029)2.20394208
46Premature graying of hair (HP:0002216)2.18009708
47Increased muscle lipid content (HP:0009058)2.16242418
48Asplenia (HP:0001746)2.15851856
49Recurrent viral infections (HP:0004429)2.15584795
50Type I transferrin isoform profile (HP:0003642)2.15237831
51Hepatocellular necrosis (HP:0001404)2.14271761
52Missing ribs (HP:0000921)2.13554048
53Abnormality of the anterior horn cell (HP:0006802)2.12953992
54Degeneration of anterior horn cells (HP:0002398)2.12953992
55Stenosis of the external auditory canal (HP:0000402)2.12016330
56Agnosia (HP:0010524)2.11793551
57Multiple enchondromatosis (HP:0005701)2.11575777
58Breast hypoplasia (HP:0003187)2.11348423
59Depressed nasal ridge (HP:0000457)2.11262066
60IgG deficiency (HP:0004315)2.11236957
61Increased serum lactate (HP:0002151)2.10304620
62Panhypogammaglobulinemia (HP:0003139)2.07091223
63Progressive muscle weakness (HP:0003323)2.05619298
64Medulloblastoma (HP:0002885)2.04435104
65Cerebral edema (HP:0002181)2.02319207
66Abnormality of the preputium (HP:0100587)2.02045237
67Abnormality of chromosome stability (HP:0003220)2.01657801
68Trismus (HP:0000211)2.01191360
69Entropion (HP:0000621)2.00966992
70Neoplasm of the pancreas (HP:0002894)2.00800393
71Glossoptosis (HP:0000162)1.99973949
72Abnormality of small intestinal villus morphology (HP:0011472)1.98977855
73Villous atrophy (HP:0011473)1.98977855
74Cellular immunodeficiency (HP:0005374)1.97966064
75Pancytopenia (HP:0001876)1.97195048
76Progressive macrocephaly (HP:0004481)1.97159192
77Patellar aplasia (HP:0006443)1.96812920
78Horseshoe kidney (HP:0000085)1.96349629
79Exertional dyspnea (HP:0002875)1.96285379
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.95127088
81Squamous cell carcinoma (HP:0002860)1.94865255
82Progressive external ophthalmoplegia (HP:0000590)1.94684874
83Bone marrow hypocellularity (HP:0005528)1.94239442
84Reduced antithrombin III activity (HP:0001976)1.94136487
85Muscle fiber atrophy (HP:0100295)1.93648192
86Colitis (HP:0002583)1.93024247
87Abnormal number of incisors (HP:0011064)1.92522991
88Hepatic necrosis (HP:0002605)1.92359368
89Abnormality of B cell number (HP:0010975)1.91421869
90B lymphocytopenia (HP:0010976)1.91421869
91Abnormality of the prostate (HP:0008775)1.88764811
92T lymphocytopenia (HP:0005403)1.88219549
93Ependymoma (HP:0002888)1.87313558
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85648345
95Aplasia/Hypoplasia of the patella (HP:0006498)1.85141644
96Premature ovarian failure (HP:0008209)1.84922691
97Seborrheic dermatitis (HP:0001051)1.83162211
98Abnormality of DNA repair (HP:0003254)1.82440302
99Lactic acidosis (HP:0003128)1.81419424
100Gastrointestinal inflammation (HP:0004386)1.81219507
101Meckel diverticulum (HP:0002245)1.80544135
102Autoimmune hemolytic anemia (HP:0001890)1.80057949
103Atresia of the external auditory canal (HP:0000413)1.79812898
104Severe combined immunodeficiency (HP:0004430)1.79537153
105Abnormality of cells of the lymphoid lineage (HP:0012140)1.79398647
106Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78702806
107Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78702806
108Abnormal hemoglobin (HP:0011902)1.78593693
109Thick lower lip vermilion (HP:0000179)1.78078917
110Lymphopenia (HP:0001888)1.77623909
111Myositis (HP:0100614)1.77040811
112Abnormality of methionine metabolism (HP:0010901)1.76789583
113Hypoplasia of the radius (HP:0002984)1.76037528
114Congenital, generalized hypertrichosis (HP:0004540)1.75833458
115Abnormality of the parietal bone (HP:0002696)1.75584117
116Aplasia/Hypoplasia of the thymus (HP:0010515)1.75037661
117Abnormality of T cell number (HP:0011839)1.74780955
118Cellulitis (HP:0100658)1.73955579
119Abnormality of the ileum (HP:0001549)1.73952515
120Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73912031
121Neutropenia (HP:0001875)1.73579406
122Combined immunodeficiency (HP:0005387)1.72475533
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.71875723
124Cutaneous melanoma (HP:0012056)1.70524402
125Triphalangeal thumb (HP:0001199)1.70213326
126Proximal placement of thumb (HP:0009623)1.69698652
127Deviation of the thumb (HP:0009603)1.69403588
128Acute myeloid leukemia (HP:0004808)1.69392170
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.68323361
130Exercise intolerance (HP:0003546)1.67985794
131Microvesicular hepatic steatosis (HP:0001414)1.67524756
132Optic nerve coloboma (HP:0000588)1.67254696
133Prolonged bleeding time (HP:0003010)1.67139940
134Nephroblastoma (Wilms tumor) (HP:0002667)1.66397574
135Migraine (HP:0002076)1.66378625
136Cleft eyelid (HP:0000625)1.65977028
137Abnormality of the heme biosynthetic pathway (HP:0010472)1.65641199
138Type 2 muscle fiber atrophy (HP:0003554)1.65109190
139Granulocytopenia (HP:0001913)1.64446054
140Abnormal lung lobation (HP:0002101)1.64116150
141Agammaglobulinemia (HP:0004432)1.63994866
142Abnormal trabecular bone morphology (HP:0100671)1.63839148
143Inflammation of the large intestine (HP:0002037)1.63239432
144Small intestinal stenosis (HP:0012848)1.62710504
145Duodenal stenosis (HP:0100867)1.62710504
146Neoplasm of the colon (HP:0100273)1.62649224
147Viral hepatitis (HP:0006562)1.62475133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.98229261
2NME23.69361093
3WEE13.41069916
4BUB13.31692766
5EEF2K3.08539500
6CDC72.82764704
7PASK2.41076571
8PBK2.40253552
9MAP4K12.39639877
10EIF2AK12.39468688
11TGFBR12.39381527
12SMG12.31098691
13TSSK62.17622582
14TAF12.14059864
15STK162.12330435
16SRPK11.97900441
17VRK11.92160694
18EIF2AK31.90225829
19ACVR1B1.90127726
20NEK21.87733004
21LRRK21.84693721
22FLT31.81441268
23TLK11.79395731
24PIM21.76971076
25BRSK21.69035905
26MKNK11.68239322
27PRPF4B1.59002396
28DYRK31.55108135
29NUAK11.52348165
30BTK1.47055639
31TEC1.44761086
32NME11.43714476
33AURKB1.42270897
34RPS6KA41.41057771
35CDK71.38482960
36ATR1.38352951
37STK101.36839482
38KIT1.35275946
39PKN21.32898864
40MST41.29161661
41SCYL21.29000680
42PIM11.24202770
43ZAP701.20175522
44PLK41.19958504
45PLK11.19650869
46* RPS6KB21.18029929
47MAP2K31.16774850
48MAP3K101.15681631
49MAPKAPK31.13341198
50CDK41.10795959
51PAK41.08951857
52TESK21.06385404
53NEK11.05788377
54MAP3K81.04904580
55JAK31.04598372
56TTK1.01757731
57TXK0.99937216
58STK40.93803511
59KDR0.92993147
60CSF1R0.90902615
61ILK0.89296282
62MKNK20.89201258
63EPHA20.89045292
64MAP3K130.87230359
65ZAK0.84660577
66TYK20.84055423
67CDK80.83891762
68GRK60.82357061
69STK240.80249257
70PLK30.79636785
71CHEK10.79319124
72IKBKB0.78264083
73MAP3K140.75877862
74BRSK10.74712934
75SYK0.73787833
76NLK0.72050751
77CSNK2A20.72036424
78RPS6KA50.70057523
79MAP3K30.69786383
80CHEK20.67487257
81ITK0.67200806
82CLK10.66937477
83AURKA0.63448676
84BLK0.63046384
85IRAK40.61444865
86LCK0.59460384
87CSNK2A10.59410756
88CDK90.57922454
89CDK60.57556831
90LYN0.56129847
91MAP2K20.54275999
92FES0.53804997
93* ATM0.51391194
94TBK10.51174729
95CCNB10.50890764
96CDK190.50778022
97BMPR20.50635287
98CDK20.49816482
99CDK30.48237052
100PAK10.47934540
101MAPKAPK50.47377002
102EIF2AK20.47141416
103DAPK30.46408325
104ALK0.45462621
105STK30.45334631
106DAPK10.44179365
107IKBKE0.43259686
108TAOK30.41991362
109CDK120.41518341
110BRD40.38000187
111MATK0.37869294
112CDK10.37403432
113BCKDK0.36268959
114TGFBR20.35225709
115TESK10.34604521
116MELK0.34218929
117CHUK0.33867977
118MAP3K110.33828053
119RAF10.33353197
120CSNK1E0.33135065
121TRPM70.32837641
122MAPKAPK20.31901899
123BRAF0.29735701

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.75455479
2DNA replication_Homo sapiens_hsa030304.44503585
3Mismatch repair_Homo sapiens_hsa034303.72901423
4Proteasome_Homo sapiens_hsa030503.08227631
5Spliceosome_Homo sapiens_hsa030403.03168081
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95732405
7RNA polymerase_Homo sapiens_hsa030202.85460150
8Base excision repair_Homo sapiens_hsa034102.71994039
9Nucleotide excision repair_Homo sapiens_hsa034202.62267402
10Homologous recombination_Homo sapiens_hsa034402.54648782
11RNA transport_Homo sapiens_hsa030132.46847225
12Pyrimidine metabolism_Homo sapiens_hsa002402.25817880
13Non-homologous end-joining_Homo sapiens_hsa034502.15165002
14One carbon pool by folate_Homo sapiens_hsa006702.12686418
15Cell cycle_Homo sapiens_hsa041102.03214146
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01463465
17RNA degradation_Homo sapiens_hsa030181.72542200
18Fanconi anemia pathway_Homo sapiens_hsa034601.68633124
19Primary immunodeficiency_Homo sapiens_hsa053401.64680684
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55890292
21Basal transcription factors_Homo sapiens_hsa030221.46408429
22Antigen processing and presentation_Homo sapiens_hsa046121.43238953
23Protein export_Homo sapiens_hsa030601.43084829
24p53 signaling pathway_Homo sapiens_hsa041151.38176908
25Systemic lupus erythematosus_Homo sapiens_hsa053221.35362034
26mRNA surveillance pathway_Homo sapiens_hsa030151.22215456
27Epstein-Barr virus infection_Homo sapiens_hsa051691.17421120
28Herpes simplex infection_Homo sapiens_hsa051681.17064131
29Purine metabolism_Homo sapiens_hsa002301.10864874
30Autoimmune thyroid disease_Homo sapiens_hsa053201.02959289
31Alzheimers disease_Homo sapiens_hsa050100.98542834
32Viral carcinogenesis_Homo sapiens_hsa052030.96748642
33Measles_Homo sapiens_hsa051620.89061062
34Hematopoietic cell lineage_Homo sapiens_hsa046400.87324732
35NF-kappa B signaling pathway_Homo sapiens_hsa040640.85709223
36Legionellosis_Homo sapiens_hsa051340.85507343
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83027966
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81540744
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80097740
40Intestinal immune network for IgA production_Homo sapiens_hsa046720.78980853
41HTLV-I infection_Homo sapiens_hsa051660.77392131
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74561853
43Type I diabetes mellitus_Homo sapiens_hsa049400.73115965
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71893429
45Pentose phosphate pathway_Homo sapiens_hsa000300.71831124
46Thyroid cancer_Homo sapiens_hsa052160.70165007
47N-Glycan biosynthesis_Homo sapiens_hsa005100.69235752
48Folate biosynthesis_Homo sapiens_hsa007900.67141221
49Apoptosis_Homo sapiens_hsa042100.65420207
50Small cell lung cancer_Homo sapiens_hsa052220.65408378
51Parkinsons disease_Homo sapiens_hsa050120.65146180
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63053251
53Allograft rejection_Homo sapiens_hsa053300.61453707
54Carbon metabolism_Homo sapiens_hsa012000.61337659
55Sulfur relay system_Homo sapiens_hsa041220.59454566
56B cell receptor signaling pathway_Homo sapiens_hsa046620.59305996
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58607703
58Leishmaniasis_Homo sapiens_hsa051400.58075905
59Huntingtons disease_Homo sapiens_hsa050160.57018514
60Hepatitis B_Homo sapiens_hsa051610.56078975
61Acute myeloid leukemia_Homo sapiens_hsa052210.55877387
62Pyruvate metabolism_Homo sapiens_hsa006200.55790764
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.53882239
64Shigellosis_Homo sapiens_hsa051310.53587433
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.52600712
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51909313
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50449950
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48839614
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48814591
70Propanoate metabolism_Homo sapiens_hsa006400.47260320
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.46550879
72Influenza A_Homo sapiens_hsa051640.46344026
73Alcoholism_Homo sapiens_hsa050340.45390576
74Chronic myeloid leukemia_Homo sapiens_hsa052200.44758402
75Asthma_Homo sapiens_hsa053100.44596363
76T cell receptor signaling pathway_Homo sapiens_hsa046600.42604911
77Selenocompound metabolism_Homo sapiens_hsa004500.42437851
78MicroRNAs in cancer_Homo sapiens_hsa052060.42220752
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38086891
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37107144
81Oxidative phosphorylation_Homo sapiens_hsa001900.36703303
82Toxoplasmosis_Homo sapiens_hsa051450.36521784
83Colorectal cancer_Homo sapiens_hsa052100.36289481
84Viral myocarditis_Homo sapiens_hsa054160.36040937
85Biosynthesis of amino acids_Homo sapiens_hsa012300.35944579
86Pancreatic cancer_Homo sapiens_hsa052120.34934753
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.34627167
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34428241
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.34420278
90Metabolic pathways_Homo sapiens_hsa011000.33624749
91Glutathione metabolism_Homo sapiens_hsa004800.33481704
92Notch signaling pathway_Homo sapiens_hsa043300.33324781
93Graft-versus-host disease_Homo sapiens_hsa053320.32206073
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32135145
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32037094
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31200150
97Vitamin digestion and absorption_Homo sapiens_hsa049770.28433753
98Cardiac muscle contraction_Homo sapiens_hsa042600.27453459
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26828581
100Pathways in cancer_Homo sapiens_hsa052000.26686267
101Galactose metabolism_Homo sapiens_hsa000520.25958057
102Oocyte meiosis_Homo sapiens_hsa041140.25758499
103Other glycan degradation_Homo sapiens_hsa005110.24184214
104TGF-beta signaling pathway_Homo sapiens_hsa043500.23732036
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23549837
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23454205
107Platelet activation_Homo sapiens_hsa046110.23146218
108Osteoclast differentiation_Homo sapiens_hsa043800.23129736
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22897101
110Fatty acid elongation_Homo sapiens_hsa000620.21913565
111Renin-angiotensin system_Homo sapiens_hsa046140.21814747
112* HIF-1 signaling pathway_Homo sapiens_hsa040660.20576248
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19603220
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19527177
115Non-small cell lung cancer_Homo sapiens_hsa052230.19032033
116Regulation of autophagy_Homo sapiens_hsa041400.18400050
117Prostate cancer_Homo sapiens_hsa052150.16289386
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14020735
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13978363
120Peroxisome_Homo sapiens_hsa041460.10017890
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.09672401
122Arachidonic acid metabolism_Homo sapiens_hsa005900.09058607
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08715502
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08563906

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