RPS6KA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77577961
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77577961
3detection of other organism (GO:0098543)4.65104250
4detection of bacterium (GO:0016045)4.53370495
5positive regulation of gamma-delta T cell activation (GO:0046645)4.35899857
6antigen processing and presentation of endogenous antigen (GO:0019883)4.31749974
7macrophage activation involved in immune response (GO:0002281)4.29408334
8ribosomal small subunit assembly (GO:0000028)3.85643926
9detection of external biotic stimulus (GO:0098581)3.82559672
10leukocyte aggregation (GO:0070486)3.77452055
11regulation of B cell receptor signaling pathway (GO:0050855)3.70609857
12Arp2/3 complex-mediated actin nucleation (GO:0034314)3.70258641
13positive regulation of B cell differentiation (GO:0045579)3.63460875
14neutrophil activation (GO:0042119)3.61161068
15negative regulation of lymphocyte mediated immunity (GO:0002707)3.60627165
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57408089
17regulation of mast cell degranulation (GO:0043304)3.51410445
18granulocyte activation (GO:0036230)3.46177294
19negative regulation of phagocytosis (GO:0050765)3.45467586
20response to host immune response (GO:0052572)3.42948184
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42948184
22DNA unwinding involved in DNA replication (GO:0006268)3.41679354
23DNA strand elongation involved in DNA replication (GO:0006271)3.41669134
24myeloid cell activation involved in immune response (GO:0002275)3.41620479
25detection of biotic stimulus (GO:0009595)3.38321334
26regulation of gamma-delta T cell differentiation (GO:0045586)3.37613645
27positive thymic T cell selection (GO:0045059)3.37351894
28regulation of myeloid leukocyte mediated immunity (GO:0002886)3.37219399
29detection of molecule of bacterial origin (GO:0032490)3.37068256
30negative regulation of leukocyte mediated immunity (GO:0002704)3.35732307
31regulation of leukocyte degranulation (GO:0043300)3.33304901
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32569082
33response to interleukin-15 (GO:0070672)3.32523277
34cellular response to type I interferon (GO:0071357)3.30832021
35type I interferon signaling pathway (GO:0060337)3.30832021
36response to type I interferon (GO:0034340)3.28295410
37negative thymic T cell selection (GO:0045060)3.27966848
38interferon-gamma-mediated signaling pathway (GO:0060333)3.27895431
39DNA strand elongation (GO:0022616)3.25066239
40regulation of gamma-delta T cell activation (GO:0046643)3.22540253
41germinal center formation (GO:0002467)3.21955438
42protein localization to kinetochore (GO:0034501)3.21898830
43immunoglobulin mediated immune response (GO:0016064)3.20866280
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.20729955
45regulation of B cell differentiation (GO:0045577)3.19409493
46negative regulation of T cell mediated immunity (GO:0002710)3.18944374
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18718389
48positive regulation of mast cell activation (GO:0033005)3.17974281
49regulation of mast cell activation involved in immune response (GO:0033006)3.17400566
50negative T cell selection (GO:0043383)3.16483788
51B cell mediated immunity (GO:0019724)3.15426648
52lipopolysaccharide-mediated signaling pathway (GO:0031663)3.14798653
53response to host (GO:0075136)3.14249216
54response to host defenses (GO:0052200)3.14249216
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14249216
56telomere maintenance via semi-conservative replication (GO:0032201)3.13453092
57respiratory burst (GO:0045730)3.07821667
58regulation of T cell tolerance induction (GO:0002664)3.06786921
59regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05088090
60macrophage activation (GO:0042116)3.02650591
61regulation of tolerance induction (GO:0002643)3.01722985
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01271003
63viral transcription (GO:0019083)3.00779885
64response to fungus (GO:0009620)2.99883566
65DNA replication initiation (GO:0006270)2.96560376
66microglial cell activation (GO:0001774)2.96247130
67regulation of mast cell activation (GO:0033003)2.96126877
68defense response to fungus (GO:0050832)2.95382181
69positive regulation of antigen processing and presentation (GO:0002579)2.94994804
70negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.94689467
71cellular response to interleukin-15 (GO:0071350)2.94511159
72regulation of antigen processing and presentation (GO:0002577)2.93916326
73T cell selection (GO:0045058)2.91656617
74leukocyte degranulation (GO:0043299)2.90911991
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90662903
76translational termination (GO:0006415)2.88796765
77production of molecular mediator involved in inflammatory response (GO:0002532)2.87254021
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87186344
79thymic T cell selection (GO:0045061)2.85123541
80regulation of T-helper 2 cell differentiation (GO:0045628)2.84034015
81response to peptidoglycan (GO:0032494)2.83631532
82leukocyte migration involved in inflammatory response (GO:0002523)2.83493323
83negative regulation of innate immune response (GO:0045824)2.82799941
84regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81724222
85protein localization to chromosome, centromeric region (GO:0071459)2.81446773
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.80862303
87regulation of natural killer cell mediated immunity (GO:0002715)2.80862303
88myeloid dendritic cell activation (GO:0001773)2.80530851
89formation of translation preinitiation complex (GO:0001731)2.78964225
90telomere maintenance via recombination (GO:0000722)2.78384080
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78374991
92macrophage differentiation (GO:0030225)2.77153000
93regulation of regulated secretory pathway (GO:1903305)2.76739433
94myeloid dendritic cell differentiation (GO:0043011)2.76165641
95positive regulation of mast cell activation involved in immune response (GO:0033008)2.75403221
96pentose-phosphate shunt (GO:0006098)2.73873235
97IMP metabolic process (GO:0046040)2.73482349
98neutrophil mediated immunity (GO:0002446)2.73214856
99cellular extravasation (GO:0045123)2.72500748
100negative regulation of erythrocyte differentiation (GO:0045647)2.71356963
101regulation of interferon-beta biosynthetic process (GO:0045357)2.70278968
102antigen processing and presentation via MHC class Ib (GO:0002475)2.66829614
103IMP biosynthetic process (GO:0006188)2.65814602
1043-UTR-mediated mRNA stabilization (GO:0070935)2.63612601
105translational elongation (GO:0006414)2.62619867
106actin nucleation (GO:0045010)2.62117632
107mitotic recombination (GO:0006312)2.60986478
108negative regulation of interleukin-12 production (GO:0032695)2.60934829
109hepatocyte apoptotic process (GO:0097284)2.59584016
110response to protozoan (GO:0001562)2.58628044
111B cell receptor signaling pathway (GO:0050853)2.58507485
112neutrophil activation involved in immune response (GO:0002283)2.57520216
113maturation of SSU-rRNA (GO:0030490)2.56498549
114negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53839673
115negative regulation of cell killing (GO:0031342)2.53839673
116nucleobase biosynthetic process (GO:0046112)2.53497596
117modulation by symbiont of host defense response (GO:0052031)2.52761458
118modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52761458
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52761458
120positive regulation by organism of defense response of other organism involved in symbiotic interact2.52761458
121modulation by symbiont of host immune response (GO:0052553)2.52761458
122positive regulation by symbiont of host defense response (GO:0052509)2.52761458
123defense response to protozoan (GO:0042832)2.51198382
124positive regulation of lamellipodium assembly (GO:0010592)2.50172850
125T cell migration (GO:0072678)2.48392576
126nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.47843883
127cellular response to zinc ion (GO:0071294)2.47053212
128mitotic nuclear envelope disassembly (GO:0007077)2.45271551
129pinocytosis (GO:0006907)2.45170317
130leukocyte cell-cell adhesion (GO:0007159)2.40737832
131SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.40450893
132DNA duplex unwinding (GO:0032508)2.39392226
133ribosomal small subunit biogenesis (GO:0042274)2.39058077
134translational initiation (GO:0006413)2.37563070
135DNA deamination (GO:0045006)2.36683634
136DNA geometric change (GO:0032392)2.36538553
137regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35539020
138NADPH regeneration (GO:0006740)2.35330772
139regulation of erythrocyte differentiation (GO:0045646)2.34340397
140negative regulation of granulocyte differentiation (GO:0030853)2.34247662
141leukocyte mediated cytotoxicity (GO:0001909)2.34087455
142mast cell activation (GO:0045576)2.33903648
143DNA replication checkpoint (GO:0000076)2.33260940
144telomere maintenance via telomere lengthening (GO:0010833)2.32244195
145protein targeting to ER (GO:0045047)2.32115064
146NIK/NF-kappaB signaling (GO:0038061)2.32083311
147cotranslational protein targeting to membrane (GO:0006613)2.31403450
148response to muramyl dipeptide (GO:0032495)2.31318116
149viral life cycle (GO:0019058)2.30271650
150angiogenesis involved in wound healing (GO:0060055)2.28930467
151T cell homeostasis (GO:0043029)2.28644230
152interferon-gamma production (GO:0032609)2.27948790
153response to interferon-beta (GO:0035456)2.25399862
154positive regulation of lamellipodium organization (GO:1902745)2.25122061
155regulation of response to interferon-gamma (GO:0060330)2.24877325
156positive regulation of interferon-alpha production (GO:0032727)2.23964954
157killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.23877095
158disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.23877095
159regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.22353397
160nuclear pore complex assembly (GO:0051292)2.22139108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.00357087
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.04937356
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93535864
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.85482901
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.77753052
6MYC_22102868_ChIP-Seq_BL_Human2.66033327
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58143260
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.47953498
9* VDR_21846776_ChIP-Seq_THP-1_Human2.47606444
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42737765
11SCL_19346495_ChIP-Seq_HPC-7_Human2.37579364
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.33713944
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.29433007
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26959095
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20545571
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17789053
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17377594
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15978212
19* SPI1_23547873_ChIP-Seq_NB4_Human2.01836911
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98064600
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.94909620
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93989869
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91984632
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90335381
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84906962
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81409340
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78326808
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77712847
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77526303
30MYB_26560356_Chip-Seq_TH2_Human1.76228710
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75899638
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.75724699
33* MAF_26560356_Chip-Seq_TH1_Human1.75637598
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75547753
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73287672
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.71582332
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.69792527
38* LXR_22292898_ChIP-Seq_THP-1_Human1.69657565
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68402835
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66589342
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62807300
42* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60887999
43* MYB_26560356_Chip-Seq_TH1_Human1.60180597
44* VDR_24763502_ChIP-Seq_THP-1_Human1.59344001
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59189079
46* UTX_26944678_Chip-Seq_JUKART_Human1.57313781
47* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56012778
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55692202
49TCF7_22412390_ChIP-Seq_EML_Mouse1.52362210
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47830335
51CIITA_25753668_ChIP-Seq_RAJI_Human1.46948904
52* GATA1_19941827_ChIP-Seq_MEL_Mouse1.46179438
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41286010
54VDR_24787735_ChIP-Seq_THP-1_Human1.40780471
55XRN2_22483619_ChIP-Seq_HELA_Human1.40406326
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38295989
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37459883
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36716573
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35414110
60VDR_23849224_ChIP-Seq_CD4+_Human1.34480386
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.33744452
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33288982
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33094503
64* E2F1_21310950_ChIP-Seq_MCF-7_Human1.32847836
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31843638
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31143102
67FOXP3_21729870_ChIP-Seq_TREG_Human1.29742118
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29499989
69* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29211163
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.29022652
71GATA1_22025678_ChIP-Seq_K562_Human1.28980159
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27225083
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26712121
74GATA1_19941826_ChIP-Seq_K562_Human1.24459755
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23139294
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21969442
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21035859
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.20708366
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19362279
80* SPI1_23127762_ChIP-Seq_K562_Human1.18948440
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18865203
82BCOR_27268052_Chip-Seq_Bcells_Human1.18017467
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17664738
84BCL6_27268052_Chip-Seq_Bcells_Human1.17482135
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17189914
86NCOR1_26117541_ChIP-Seq_K562_Human1.16820915
87* MAF_26560356_Chip-Seq_TH2_Human1.16694627
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15977437
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15976732
90AR_21909140_ChIP-Seq_LNCAP_Human1.15799375
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15555672
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15534434
93RUNX_20019798_ChIP-Seq_JUKART_Human1.15282796
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13814632
95* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13752985
96RACK7_27058665_Chip-Seq_MCF-7_Human1.13533868
97KDM5A_27292631_Chip-Seq_BREAST_Human1.12639052
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12016030
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11548048
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11495693
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11112508
102CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10649398
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.07384582
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07101530
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06725862
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06606284
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.05146952
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.04410032
109* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04181773
110GABP_19822575_ChIP-Seq_HepG2_Human1.03087428
111* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02096170
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01287844
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00456574
114TFEB_21752829_ChIP-Seq_HELA_Human1.00327337
115HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00104701
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99795842
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99137658
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.98328810
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.97781632
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97322316
121KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96159971
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96093289
123PU_27001747_Chip-Seq_BMDM_Mouse0.95929798
124MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95509688
125GATA3_26560356_Chip-Seq_TH2_Human0.94553124
126* KDM2B_26808549_Chip-Seq_DND41_Human0.94152447
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93845274
128* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92122747
129GATA3_27048872_Chip-Seq_THYMUS_Human0.92067717
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91454597
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91373580
132DCP1A_22483619_ChIP-Seq_HELA_Human0.90715744
133* SA1_27219007_Chip-Seq_ERYTHROID_Human0.90560576
134GATA2_19941826_ChIP-Seq_K562_Human0.90338748
135* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88990703
136P68_20966046_ChIP-Seq_HELA_Human0.88288775
137* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87624174
138NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87415171
139VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86724676
140* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85460065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.35268248
2MP0002396_abnormal_hematopoietic_system2.95570295
3MP0003693_abnormal_embryo_hatching2.76009014
4MP0003436_decreased_susceptibility_to2.55011769
5MP0005671_abnormal_response_to2.52242810
6MP0000685_abnormal_immune_system2.41428947
7MP0009785_altered_susceptibility_to2.41189943
8MP0005025_abnormal_response_to2.29988838
9MP0001800_abnormal_humoral_immune2.29833924
10MP0003303_peritoneal_inflammation2.29235530
11MP0005451_abnormal_body_composition2.22752499
12MP0005464_abnormal_platelet_physiology2.22609126
13MP0002452_abnormal_antigen_presenting2.18210364
14MP0000490_abnormal_crypts_of2.15602992
15MP0003763_abnormal_thymus_physiology2.14332169
16MP0001819_abnormal_immune_cell2.14282727
17MP0002420_abnormal_adaptive_immunity2.14258271
18MP0002398_abnormal_bone_marrow2.13549007
19MP0002419_abnormal_innate_immunity2.11461160
20MP0010094_abnormal_chromosome_stability2.10001397
21MP0004957_abnormal_blastocyst_morpholog2.07870761
22MP0009333_abnormal_splenocyte_physiolog2.04789868
23MP0010155_abnormal_intestine_physiology2.03418158
24MP0002723_abnormal_immune_serum2.03365256
25MP0005000_abnormal_immune_tolerance2.02439467
26MP0010352_gastrointestinal_tract_polyps2.02360210
27MP0003111_abnormal_nucleus_morphology2.00946501
28MP0001873_stomach_inflammation1.97487640
29MP0003077_abnormal_cell_cycle1.96710332
30MP0008260_abnormal_autophagy1.96053060
31MP0008057_abnormal_DNA_replication1.91150167
32MP0004808_abnormal_hematopoietic_stem1.89852512
33MP0000716_abnormal_immune_system1.86985090
34MP0002722_abnormal_immune_system1.86063930
35MP0000689_abnormal_spleen_morphology1.85831664
36MP0001790_abnormal_immune_system1.84899791
37MP0005387_immune_system_phenotype1.84899791
38MP0002166_altered_tumor_susceptibility1.84628933
39MP0002148_abnormal_hypersensitivity_rea1.83859348
40MP0002405_respiratory_system_inflammati1.82881073
41MP0001545_abnormal_hematopoietic_system1.80372078
42MP0005397_hematopoietic_system_phenotyp1.80372078
43MP0000465_gastrointestinal_hemorrhage1.79249778
44MP0003300_gastrointestinal_ulcer1.76432852
45MP0009278_abnormal_bone_marrow1.75799159
46MP0003866_abnormal_defecation1.75493583
47MP0002429_abnormal_blood_cell1.71953107
48MP0006054_spinal_hemorrhage1.68359940
49MP0006082_CNS_inflammation1.62132145
50MP0001845_abnormal_inflammatory_respons1.54805293
51MP0010307_abnormal_tumor_latency1.54701837
52MP0001853_heart_inflammation1.54544102
53MP0002006_tumorigenesis1.53445362
54MP0003191_abnormal_cellular_cholesterol1.51708991
55MP0000703_abnormal_thymus_morphology1.49407868
56MP0003172_abnormal_lysosome_physiology1.47374239
57MP0004947_skin_inflammation1.42791335
58MP0000858_altered_metastatic_potential1.41142160
59MP0005058_abnormal_lysosome_morphology1.37912043
60MP0008058_abnormal_DNA_repair1.36729917
61MP0005174_abnormal_tail_pigmentation1.36029906
62MP0002998_abnormal_bone_remodeling1.32611857
63MP0003075_altered_response_to1.29164739
64MP0008007_abnormal_cellular_replicative1.28808422
65MP0002019_abnormal_tumor_incidence1.28750594
66MP0004510_myositis1.26618324
67MP0009764_decreased_sensitivity_to1.25684625
68MP0009840_abnormal_foam_cell1.24205477
69MP0004264_abnormal_extraembryonic_tissu1.22906317
70MP0000604_amyloidosis1.19213329
71MP0003724_increased_susceptibility_to1.18822173
72MP0003806_abnormal_nucleotide_metabolis1.18736847
73MP0005075_abnormal_melanosome_morpholog1.18663108
74MP0005166_decreased_susceptibility_to1.14714893
75MP0003566_abnormal_cell_adhesion1.12073703
76MP0000350_abnormal_cell_proliferation1.11851076
77MP0003183_abnormal_peptide_metabolism1.11499767
78MP0008469_abnormal_protein_level1.10774932
79MP0004381_abnormal_hair_follicle1.09534839
80MP0000313_abnormal_cell_death1.05679266
81MP0003448_altered_tumor_morphology1.05162994
82MP0001533_abnormal_skeleton_physiology1.04437715
83MP0001730_embryonic_growth_arrest1.04104693
84MP0005023_abnormal_wound_healing1.03440970
85MP0000477_abnormal_intestine_morphology0.99458855
86MP0003656_abnormal_erythrocyte_physiolo0.98296659
87MP0000343_altered_response_to0.96781180
88MP0004883_abnormal_blood_vessel0.96402683
89MP0008004_abnormal_stomach_pH0.93516715
90MP0001851_eye_inflammation0.93152907
91MP0005310_abnormal_salivary_gland0.93081285
92MP0003690_abnormal_glial_cell0.90868255
93MP0001663_abnormal_digestive_system0.90484019
94MP0005076_abnormal_cell_differentiation0.89549762
95MP0010234_abnormal_vibrissa_follicle0.88151286
96MP0002086_abnormal_extraembryonic_tissu0.86897580
97MP0003453_abnormal_keratinocyte_physiol0.86890463
98MP0002277_abnormal_respiratory_mucosa0.85368979
99MP0001915_intracranial_hemorrhage0.79591508
100MP0005164_abnormal_response_to0.77517326
101MP0005380_embryogenesis_phenotype0.76430114
102MP0001672_abnormal_embryogenesis/_devel0.76430114
103MP0002080_prenatal_lethality0.75894475
104MP0003984_embryonic_growth_retardation0.75221204
105MP0001697_abnormal_embryo_size0.74857692
106MP0008873_increased_physiological_sensi0.74730699
107MP0001849_ear_inflammation0.74130415
108MP0002088_abnormal_embryonic_growth/wei0.72554223
109MP0003091_abnormal_cell_migration0.69120743
110MP0005390_skeleton_phenotype0.68713904
111MP0002933_joint_inflammation0.67973656
112MP0002132_abnormal_respiratory_system0.67886775
113MP0003795_abnormal_bone_structure0.67321886
114MP0002877_abnormal_melanocyte_morpholog0.66624126
115MP0002138_abnormal_hepatobiliary_system0.65749485
116MP0008932_abnormal_embryonic_tissue0.64651238
117MP0004185_abnormal_adipocyte_glucose0.63735416
118MP0002139_abnormal_hepatobiliary_system0.63340961
119MP0003828_pulmonary_edema0.63292441
120MP0000015_abnormal_ear_pigmentation0.63291821
121MP0000609_abnormal_liver_physiology0.63211127
122MP0009765_abnormal_xenobiotic_induced0.62928435
123MP0009763_increased_sensitivity_to0.62590980
124MP0000371_diluted_coat_color0.62232944
125MP0000598_abnormal_liver_morphology0.61589657
126MP0003329_amyloid_beta_deposits0.61291736
127MP0000249_abnormal_blood_vessel0.60121077
128MP0008874_decreased_physiological_sensi0.58448224
129MP0005319_abnormal_enzyme/_coenzyme0.57352048
130MP0003045_fibrosis0.55174810

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.75048746
2Recurrent bacterial skin infections (HP:0005406)5.24463049
3Eczematoid dermatitis (HP:0000976)4.88432597
4Thrombocytosis (HP:0001894)4.24029786
5Agnosia (HP:0010524)4.04169254
6IgM deficiency (HP:0002850)3.99481292
7Elevated erythrocyte sedimentation rate (HP:0003565)3.86252166
8Myositis (HP:0100614)3.64813062
9Recurrent fungal infections (HP:0002841)3.58966914
10Recurrent viral infections (HP:0004429)3.48267868
11Pustule (HP:0200039)3.36387678
12Petechiae (HP:0000967)3.35483167
13Chronic otitis media (HP:0000389)3.32203559
14Abnormality of glycolipid metabolism (HP:0010969)3.29569742
15Abnormality of liposaccharide metabolism (HP:0010968)3.29569742
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.29569742
17Gastrointestinal infarctions (HP:0005244)3.27863389
18Recurrent skin infections (HP:0001581)3.26200431
19Chronic obstructive pulmonary disease (HP:0006510)3.22582495
20Obstructive lung disease (HP:0006536)3.22582495
21Increased cerebral lipofuscin (HP:0011813)3.19110516
22Abnormality of macrophages (HP:0004311)3.17448145
23Recurrent gram-negative bacterial infections (HP:0005420)3.06702621
24Abnormality of T cell physiology (HP:0011840)3.05104067
25Mediastinal lymphadenopathy (HP:0100721)2.94752134
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.91120083
27Abnormality of cells of the erythroid lineage (HP:0012130)2.88966946
28Keratoconjunctivitis sicca (HP:0001097)2.88723822
29Abnormal number of erythroid precursors (HP:0012131)2.85036323
30Cellulitis (HP:0100658)2.81886701
31Meningitis (HP:0001287)2.78505486
32Nasal polyposis (HP:0100582)2.77993389
33Abnormality of T cells (HP:0002843)2.74888997
34Agammaglobulinemia (HP:0004432)2.74809610
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.73599274
36Reticulocytopenia (HP:0001896)2.73478044
37Pulmonary infiltrates (HP:0002113)2.64975980
38Gastrointestinal inflammation (HP:0004386)2.62334657
39Loss of speech (HP:0002371)2.61651783
40Recurrent bronchitis (HP:0002837)2.61275906
41Inflammation of the large intestine (HP:0002037)2.60793067
42Keratoconjunctivitis (HP:0001096)2.60470103
43Gingivitis (HP:0000230)2.58550717
44Abnormality of the nasal mucosa (HP:0000433)2.55106503
45Interstitial pulmonary disease (HP:0006530)2.53114121
46Periodontitis (HP:0000704)2.52553915
47Vacuolated lymphocytes (HP:0001922)2.47056099
48Purpura (HP:0000979)2.45620079
49Colitis (HP:0002583)2.40660122
50Amaurosis fugax (HP:0100576)2.39569254
51Chronic mucocutaneous candidiasis (HP:0002728)2.39365839
52Recurrent cutaneous fungal infections (HP:0011370)2.39365839
53Increased IgM level (HP:0003496)2.38927181
54Hepatosplenomegaly (HP:0001433)2.38150884
55Spontaneous hematomas (HP:0007420)2.37226271
56Abnormality of the prostate (HP:0008775)2.37052991
57Orchitis (HP:0100796)2.36608830
58Autoimmune thrombocytopenia (HP:0001973)2.34256092
59Panhypogammaglobulinemia (HP:0003139)2.33874770
60Abnormal platelet function (HP:0011869)2.33854479
61Impaired platelet aggregation (HP:0003540)2.33854479
62Amyloidosis (HP:0011034)2.33798875
63Gastrointestinal stroma tumor (HP:0100723)2.33202796
64Abnormal platelet volume (HP:0011876)2.31523877
65Granulocytopenia (HP:0001913)2.29646833
66Leukocytosis (HP:0001974)2.28471353
67Aplastic anemia (HP:0001915)2.26964786
68Prolonged bleeding time (HP:0003010)2.26855646
69Sepsis (HP:0100806)2.26850498
70Dysostosis multiplex (HP:0000943)2.26562758
71Basal cell carcinoma (HP:0002671)2.26206501
72Eosinophilia (HP:0001880)2.26051119
73B lymphocytopenia (HP:0010976)2.23306321
74Abnormality of B cell number (HP:0010975)2.23306321
75Stomatitis (HP:0010280)2.21596290
76Pulmonary embolism (HP:0002204)2.21278569
77Epistaxis (HP:0000421)2.21146963
78Increased serum ferritin (HP:0003281)2.21061379
79Increased IgE level (HP:0003212)2.20958078
80Chest pain (HP:0100749)2.20169107
81Spinal cord lesions (HP:0100561)2.19947972
82Syringomyelia (HP:0003396)2.19947972
83Premature loss of primary teeth (HP:0006323)2.19112595
84Malnutrition (HP:0004395)2.18200862
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.18186313
86Myelodysplasia (HP:0002863)2.17770313
87T lymphocytopenia (HP:0005403)2.16666924
88Hypochromic anemia (HP:0001931)2.15920678
89Lymphopenia (HP:0001888)2.15897672
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.15876644
91Disinhibition (HP:0000734)2.14873311
92Skin ulcer (HP:0200042)2.14535181
93Lymphoma (HP:0002665)2.14356493
94Anorexia (HP:0002039)2.12184927
95Episodic fever (HP:0001954)2.11219647
96Vasculitis (HP:0002633)2.11002680
97Viral hepatitis (HP:0006562)2.08050487
98Autoimmune hemolytic anemia (HP:0001890)2.04859732
99Urticaria (HP:0001025)2.03983901
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03438878
101Abnormality of T cell number (HP:0011839)2.02139102
102Restrictive lung disease (HP:0002091)2.01463025
103Poikiloderma (HP:0001029)2.01395634
104Systemic lupus erythematosus (HP:0002725)1.98813666
105Abnormality of the fingertips (HP:0001211)1.97753627
106Abnormality of eosinophils (HP:0001879)1.97539938
107Recurrent pneumonia (HP:0006532)1.96890560
108Recurrent sinusitis (HP:0011108)1.96059568
109Abnormality of iron homeostasis (HP:0011031)1.95800122
110Retrobulbar optic neuritis (HP:0100654)1.94837879
111Optic neuritis (HP:0100653)1.94837879
112Combined immunodeficiency (HP:0005387)1.94591435
113Chronic diarrhea (HP:0002028)1.93747001
114Skin rash (HP:0000988)1.92475026
115Gangrene (HP:0100758)1.92349172
116Encephalitis (HP:0002383)1.91657677
117Ependymoma (HP:0002888)1.91576704
118Abnormality of the pleura (HP:0002103)1.90374801
119Hemoptysis (HP:0002105)1.90090734
120Increased mean platelet volume (HP:0011877)1.88978224
121Glomerulopathy (HP:0100820)1.87814642
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87593362
123Cheilitis (HP:0100825)1.87504851
124IgA deficiency (HP:0002720)1.87111126
125Gingival bleeding (HP:0000225)1.85721590
126Spondylolisthesis (HP:0003302)1.85441707
127Prostate neoplasm (HP:0100787)1.85222477
128Osteomyelitis (HP:0002754)1.84559398
129Arterial thrombosis (HP:0004420)1.83486140
130Leukopenia (HP:0001882)1.83467281
131Acute myeloid leukemia (HP:0004808)1.81048713
132Bone marrow hypocellularity (HP:0005528)1.77520146
133Degeneration of anterior horn cells (HP:0002398)1.77427302
134Abnormality of the anterior horn cell (HP:0006802)1.77427302
135Chromsome breakage (HP:0040012)1.76758291
136IgG deficiency (HP:0004315)1.76379597
137Hypergammaglobulinemia (HP:0010702)1.72553404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.10785341
2PRPF4B2.98459976
3EEF2K2.78834544
4STK102.50398322
5JAK32.44525280
6IRAK42.20935066
7BLK2.20297032
8BTK2.12171527
9TYK22.04545998
10ZAP702.03546133
11CSF1R2.01094225
12MAP3K131.99641304
13PKN21.99267674
14GRK61.98337117
15SMG11.95190339
16MAP2K31.87878394
17FLT31.87447404
18WEE11.78737308
19BUB11.72453987
20TXK1.71847991
21KIT1.64120756
22CDC71.64001397
23NME21.62448517
24TGFBR21.61227557
25NEK21.60346708
26FGR1.60291343
27TNK21.59691818
28PAK41.57319296
29ERN11.52975027
30RPS6KB21.49626597
31PIM11.46415784
32CDK121.46112833
33TESK21.42604230
34TBK11.40816726
35CLK11.40002763
36TEC1.37849588
37MAP3K11.29125225
38SYK1.28227595
39CSK1.27850950
40LRRK21.27180319
41MAP3K101.26934228
42CDK41.23822472
43EPHB11.20866865
44TSSK61.20093216
45TAOK21.20026096
46KSR21.17693652
47CDK71.14616720
48MST41.14319402
49IKBKB1.13915311
50RPS6KA41.13498198
51IRAK31.13285385
52TAOK31.12863605
53ITK1.12457828
54IKBKE1.10902753
55LCK1.10641068
56SCYL21.09407956
57SIK31.06737473
58STK41.03289187
59HCK1.03287820
60MATK1.02256941
61TRIB31.01745973
62BRSK20.99559514
63TGFBR10.98498927
64KDR0.98145773
65MAP3K140.95199363
66* MAP3K80.94480101
67FES0.92897136
68ATR0.91863679
69MAP3K110.90590984
70VRK10.86028881
71BMPR20.85853070
72YES10.85298863
73PASK0.84069081
74LYN0.83545538
75EIF2AK10.82705142
76JAK10.81546107
77CDK60.81007274
78EPHA20.80486499
79TTK0.79480118
80MARK20.78679649
81ALK0.78339226
82JAK20.76756810
83PTK60.75670932
84CDC42BPA0.73931985
85PIM20.73624844
86AURKB0.73400468
87IRAK20.73005629
88PRKG20.71287574
89TESK10.67384937
90SIK10.67061213
91IRAK10.66731746
92* PDK10.66636929
93MAPK120.66567836
94MAPKAPK30.65187860
95RIPK40.64726303
96MAP3K60.63770511
97PRKD20.63256715
98ACVR1B0.59773725
99PRKCQ0.59497115
100FGFR40.59189803
101* PDPK10.58343011
102FYN0.57954729
103CHUK0.57773957
104TRPM70.57741550
105MAP3K20.56796087
106FGFR30.55943279
107MAP2K60.55766741
108EIF2AK30.55667245
109MAPKAPK20.55631747
110SIK20.55343936
111PLK10.54941002
112MAPK110.54765695
113HIPK20.53616565
114NEK90.52575937
115STK160.52395091
116MARK30.51948799
117CDK190.51943318
118MAP3K30.50695921
119ICK0.49222414
120RIPK10.48865422
121GRK70.46865522
122TAOK10.46302696
123MAPK70.46096332
124MAP3K50.46040165
125RAF10.42435841
126RET0.41925915
127CAMKK10.40495017
128CAMKK20.39720377
129MAP2K20.39608051
130MAP3K70.37078373
131CHEK10.36392513
132CHEK20.36246550
133PIK3CG0.36052037
134TLK10.33922599
135PAK10.33593682
136DYRK30.33582464
137ARAF0.33057191
138MAP3K120.32981283
139PLK40.32226136
140PRKCD0.31949546
141DYRK1B0.29016195

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.76349159
2Mismatch repair_Homo sapiens_hsa034302.87771520
3Autoimmune thyroid disease_Homo sapiens_hsa053202.54600690
4Primary immunodeficiency_Homo sapiens_hsa053402.30054057
5Leishmaniasis_Homo sapiens_hsa051402.28012319
6Ribosome_Homo sapiens_hsa030102.21112908
7Antigen processing and presentation_Homo sapiens_hsa046122.20298993
8Base excision repair_Homo sapiens_hsa034102.16759873
9Other glycan degradation_Homo sapiens_hsa005112.05662953
10Type I diabetes mellitus_Homo sapiens_hsa049401.98340237
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91282201
12Spliceosome_Homo sapiens_hsa030401.83211784
13Homologous recombination_Homo sapiens_hsa034401.75706423
14Measles_Homo sapiens_hsa051621.66001918
15B cell receptor signaling pathway_Homo sapiens_hsa046621.65977120
16Herpes simplex infection_Homo sapiens_hsa051681.61000569
17Osteoclast differentiation_Homo sapiens_hsa043801.59687019
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59132749
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.55363702
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54573443
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.54243571
22Legionellosis_Homo sapiens_hsa051341.50319081
23Nucleotide excision repair_Homo sapiens_hsa034201.47721326
24RNA transport_Homo sapiens_hsa030131.45393471
25Cell cycle_Homo sapiens_hsa041101.43940886
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43716550
27Hematopoietic cell lineage_Homo sapiens_hsa046401.42124221
28Phagosome_Homo sapiens_hsa041451.39390146
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.36799379
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36013959
31Rheumatoid arthritis_Homo sapiens_hsa053231.34622443
32Staphylococcus aureus infection_Homo sapiens_hsa051501.33762674
33Shigellosis_Homo sapiens_hsa051311.33634586
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33210134
35Pentose phosphate pathway_Homo sapiens_hsa000301.31690359
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.30423187
37One carbon pool by folate_Homo sapiens_hsa006701.29456963
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25804375
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21813355
40Influenza A_Homo sapiens_hsa051641.20603241
41Apoptosis_Homo sapiens_hsa042101.19128167
42Fanconi anemia pathway_Homo sapiens_hsa034601.18462070
43Toxoplasmosis_Homo sapiens_hsa051451.17302814
44Pyrimidine metabolism_Homo sapiens_hsa002401.15839646
45Non-homologous end-joining_Homo sapiens_hsa034501.15365870
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14402080
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12957258
48Acute myeloid leukemia_Homo sapiens_hsa052211.12165761
49p53 signaling pathway_Homo sapiens_hsa041151.12015020
50Pertussis_Homo sapiens_hsa051331.11282114
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09113940
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07616001
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.06540388
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06178107
55Epstein-Barr virus infection_Homo sapiens_hsa051691.06176783
56Viral carcinogenesis_Homo sapiens_hsa052031.03657483
57T cell receptor signaling pathway_Homo sapiens_hsa046601.01551690
58Hepatitis B_Homo sapiens_hsa051611.01415008
59Tuberculosis_Homo sapiens_hsa051521.00587866
60Viral myocarditis_Homo sapiens_hsa054160.99393913
61African trypanosomiasis_Homo sapiens_hsa051430.98943427
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97253370
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97059708
64Chronic myeloid leukemia_Homo sapiens_hsa052200.95384108
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93256472
66RNA polymerase_Homo sapiens_hsa030200.91635910
67RNA degradation_Homo sapiens_hsa030180.91517846
68Proteasome_Homo sapiens_hsa030500.91022324
69Platelet activation_Homo sapiens_hsa046110.89343075
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87735676
71Salmonella infection_Homo sapiens_hsa051320.86183173
72Galactose metabolism_Homo sapiens_hsa000520.83528612
73Graft-versus-host disease_Homo sapiens_hsa053320.82974764
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82936724
75HTLV-I infection_Homo sapiens_hsa051660.82528968
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80976471
77Notch signaling pathway_Homo sapiens_hsa043300.78311049
78Chemokine signaling pathway_Homo sapiens_hsa040620.78264509
79Renin-angiotensin system_Homo sapiens_hsa046140.77055791
80Pancreatic cancer_Homo sapiens_hsa052120.75721691
81Systemic lupus erythematosus_Homo sapiens_hsa053220.75273208
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74201873
83Fructose and mannose metabolism_Homo sapiens_hsa000510.74162065
84Asthma_Homo sapiens_hsa053100.71732708
85mRNA surveillance pathway_Homo sapiens_hsa030150.71483157
86Prolactin signaling pathway_Homo sapiens_hsa049170.71130655
87Allograft rejection_Homo sapiens_hsa053300.68825147
88Lysosome_Homo sapiens_hsa041420.67659318
89Renal cell carcinoma_Homo sapiens_hsa052110.67512582
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.67451525
91Hepatitis C_Homo sapiens_hsa051600.66932573
92Small cell lung cancer_Homo sapiens_hsa052220.66115799
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65779157
94TNF signaling pathway_Homo sapiens_hsa046680.65771659
95Endocytosis_Homo sapiens_hsa041440.64731001
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.64368644
97N-Glycan biosynthesis_Homo sapiens_hsa005100.62271883
98Non-small cell lung cancer_Homo sapiens_hsa052230.58332843
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.57847266
100Amoebiasis_Homo sapiens_hsa051460.55627401
101Thyroid cancer_Homo sapiens_hsa052160.55363134
102Malaria_Homo sapiens_hsa051440.55248597
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52822105
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51620354
105Endometrial cancer_Homo sapiens_hsa052130.49807742
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49145151
107Bladder cancer_Homo sapiens_hsa052190.48758937
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48736376
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.48091299
110HIF-1 signaling pathway_Homo sapiens_hsa040660.45488046
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44272223
112* Neurotrophin signaling pathway_Homo sapiens_hsa047220.43786399
113GnRH signaling pathway_Homo sapiens_hsa049120.43362222
114Colorectal cancer_Homo sapiens_hsa052100.41723060
115Inositol phosphate metabolism_Homo sapiens_hsa005620.40866709
116Choline metabolism in cancer_Homo sapiens_hsa052310.40598651
117Caffeine metabolism_Homo sapiens_hsa002320.38775819
118VEGF signaling pathway_Homo sapiens_hsa043700.38699831
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.38157877
120FoxO signaling pathway_Homo sapiens_hsa040680.37762375
121Purine metabolism_Homo sapiens_hsa002300.37468617
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36518030
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36450904
124Basal transcription factors_Homo sapiens_hsa030220.35338928
125* Insulin resistance_Homo sapiens_hsa049310.35014833
126MicroRNAs in cancer_Homo sapiens_hsa052060.34115100
127Glutathione metabolism_Homo sapiens_hsa004800.33080017
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29569885
129ErbB signaling pathway_Homo sapiens_hsa040120.28004876
130Type II diabetes mellitus_Homo sapiens_hsa049300.27356278
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.27188385

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