RPS6KA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1apoptotic cell clearance (GO:0043277)4.41320032
2negative regulation of erythrocyte differentiation (GO:0045647)4.20990733
3skin morphogenesis (GO:0043589)4.04811882
4cell adhesion mediated by integrin (GO:0033627)3.97924422
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.91386074
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91386074
7activation of Rac GTPase activity (GO:0032863)3.85469004
8hemidesmosome assembly (GO:0031581)3.74952470
9stress fiber assembly (GO:0043149)3.70986633
10positive regulation of Cdc42 GTPase activity (GO:0043089)3.69498387
11antigen processing and presentation of endogenous antigen (GO:0019883)3.67264154
12positive regulation of natural killer cell differentiation (GO:0032825)3.62121148
13endodermal cell differentiation (GO:0035987)3.53150027
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.48054357
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.46030162
16positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.45586170
17pinocytosis (GO:0006907)3.40022913
18low-density lipoprotein particle clearance (GO:0034383)3.35203834
19protein heterotrimerization (GO:0070208)3.34188591
20cellular response to interferon-alpha (GO:0035457)3.34118671
21negative regulation of fatty acid transport (GO:2000192)3.25966637
22protein localization to endosome (GO:0036010)3.20466054
23focal adhesion assembly (GO:0048041)3.20151449
24cell-substrate adherens junction assembly (GO:0007045)3.20151449
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17504573
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16583548
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16583548
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.16583548
29modulation by symbiont of host immune response (GO:0052553)3.16583548
30positive regulation by symbiont of host defense response (GO:0052509)3.16583548
31modulation by symbiont of host defense response (GO:0052031)3.16583548
32wound healing, spreading of epidermal cells (GO:0035313)3.14893755
33cell-substrate junction assembly (GO:0007044)3.07226034
34regulation of leukocyte degranulation (GO:0043300)3.07198608
35apoptotic process involved in morphogenesis (GO:0060561)3.04931108
36adherens junction assembly (GO:0034333)3.03928075
37regulation of tight junction assembly (GO:2000810)3.01763402
38plasma membrane repair (GO:0001778)2.98355834
39platelet aggregation (GO:0070527)2.97420534
40barbed-end actin filament capping (GO:0051016)2.97151940
41cortical actin cytoskeleton organization (GO:0030866)2.95388187
42collagen fibril organization (GO:0030199)2.92392844
43positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.89636694
44modulation by symbiont of host cellular process (GO:0044068)2.88380140
45detection of other organism (GO:0098543)2.87711922
46response to laminar fluid shear stress (GO:0034616)2.87080482
47Arp2/3 complex-mediated actin nucleation (GO:0034314)2.86585982
48regulation of membrane protein ectodomain proteolysis (GO:0051043)2.84674676
49COPI coating of Golgi vesicle (GO:0048205)2.84178808
50Golgi transport vesicle coating (GO:0048200)2.84178808
51detection of bacterium (GO:0016045)2.83410965
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82308914
53embryonic process involved in female pregnancy (GO:0060136)2.81367105
54regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81033172
55regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.80294184
56hypotonic response (GO:0006971)2.80239182
57negative regulation of cell killing (GO:0031342)2.78694527
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78694527
59regulation of cholesterol storage (GO:0010885)2.78259440
60regulation of early endosome to late endosome transport (GO:2000641)2.77292886
61epithelial cell differentiation involved in prostate gland development (GO:0060742)2.76759201
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.76494942
63response to muramyl dipeptide (GO:0032495)2.76459700
64positive regulation of endothelial cell apoptotic process (GO:2000353)2.76379568
65regulation of interleukin-12 biosynthetic process (GO:0045075)2.75339731
66positive regulation of receptor recycling (GO:0001921)2.74057555
67neutrophil activation involved in immune response (GO:0002283)2.70181197
68peptidyl-proline hydroxylation (GO:0019511)2.70116354
69signal complex assembly (GO:0007172)2.69949509
70modulation by virus of host process (GO:0019054)2.69169701
71macrophage activation involved in immune response (GO:0002281)2.68961349
72natural killer cell differentiation (GO:0001779)2.66138558
73vascular endothelial growth factor signaling pathway (GO:0038084)2.64911496
74pentose-phosphate shunt (GO:0006098)2.64384139
75maternal placenta development (GO:0001893)2.63560578
76chondrocyte proliferation (GO:0035988)2.62526833
77regulation of macrophage cytokine production (GO:0010935)2.60986366
78response to interferon-alpha (GO:0035455)2.60912263
79positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60339810
80basement membrane organization (GO:0071711)2.60266992
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59318885
82positive regulation of interferon-alpha production (GO:0032727)2.59107430
83regulation of integrin activation (GO:0033623)2.55078762
84negative regulation of interleukin-12 production (GO:0032695)2.54991776
85JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.54543322
86regulation of mammary gland epithelial cell proliferation (GO:0033599)2.54194250
87response to peptidoglycan (GO:0032494)2.53133642
88regulation of mast cell degranulation (GO:0043304)2.52736848
89lipopolysaccharide-mediated signaling pathway (GO:0031663)2.52601801
90regulation of podosome assembly (GO:0071801)2.52260454
91cytoskeletal anchoring at plasma membrane (GO:0007016)2.52037735
92regulation of defense response to virus by virus (GO:0050690)2.51595473
93regulation of interferon-beta biosynthetic process (GO:0045357)2.50785709
94semaphorin-plexin signaling pathway (GO:0071526)2.50018505
95epithelial cell-cell adhesion (GO:0090136)2.49978984
96cortical cytoskeleton organization (GO:0030865)2.49943273
97wound healing, spreading of cells (GO:0044319)2.49918738
98positive regulation of gamma-delta T cell activation (GO:0046645)2.49090584
99positive regulation of p38MAPK cascade (GO:1900745)2.48576390
100regulation of glucose import in response to insulin stimulus (GO:2001273)2.48531433
101regulation of regulated secretory pathway (GO:1903305)2.48388218
102response to fluid shear stress (GO:0034405)2.48340003
103integrin-mediated signaling pathway (GO:0007229)2.48292655
104glucose catabolic process (GO:0006007)2.47799895
105positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.46034113
106regulation of interferon-alpha production (GO:0032647)2.44028566
107leukocyte aggregation (GO:0070486)2.43525536
108maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43333476
109regulation of superoxide anion generation (GO:0032928)2.42313453
110positive regulation of protein dephosphorylation (GO:0035307)2.42151730
111substrate-dependent cell migration (GO:0006929)2.41322908
112actin filament bundle assembly (GO:0051017)2.38772669
113actin filament bundle organization (GO:0061572)2.38772669
114collagen metabolic process (GO:0032963)2.38192099
115immunoglobulin mediated immune response (GO:0016064)2.37409103
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.37262131
117negative regulation of viral release from host cell (GO:1902187)2.37258747
118protein hydroxylation (GO:0018126)2.37221514
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.37114816
120activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.36161324
121mannose metabolic process (GO:0006013)2.35895413
122positive regulation of histone deacetylation (GO:0031065)2.35662278
123regulation of extracellular matrix disassembly (GO:0010715)2.35080208
124regulation of monocyte chemotaxis (GO:0090025)2.34235774
125response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34030766
126response to host (GO:0075136)2.34030766
127response to host defenses (GO:0052200)2.34030766
128positive regulation of lamellipodium assembly (GO:0010592)2.33915889
129regulation of dendritic cell antigen processing and presentation (GO:0002604)2.33632521
130activation of JUN kinase activity (GO:0007257)2.33504767
131thymic T cell selection (GO:0045061)2.33221386
132detection of external biotic stimulus (GO:0098581)2.32385911
133positive thymic T cell selection (GO:0045059)2.31922592
134substrate adhesion-dependent cell spreading (GO:0034446)2.31636388
135protein retention in ER lumen (GO:0006621)2.31332313
136cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.30769604
137collagen catabolic process (GO:0030574)2.30317307
138antigen processing and presentation via MHC class Ib (GO:0002475)2.30176936
139positive regulation of chemokine biosynthetic process (GO:0045080)2.29542651
140response to manganese ion (GO:0010042)2.29314270
1413-UTR-mediated mRNA stabilization (GO:0070935)2.29088459
142regulation of necrotic cell death (GO:0010939)2.28353782
143membrane raft organization (GO:0031579)2.27609990
144desmosome organization (GO:0002934)2.27341912
145response to progesterone (GO:0032570)2.26815380
146NIK/NF-kappaB signaling (GO:0038061)2.25702213
147multicellular organismal macromolecule metabolic process (GO:0044259)2.25051135
148positive regulation of nuclease activity (GO:0032075)2.24950504
149negative regulation of cell size (GO:0045792)2.24601992
150extracellular matrix disassembly (GO:0022617)2.24318497
151cellular response to virus (GO:0098586)2.22818946
152regulation of T-helper 2 cell differentiation (GO:0045628)2.22320931
153modulation by virus of host morphology or physiology (GO:0019048)2.22064710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.19288172
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.67342562
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.45330465
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.99246175
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.71590947
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.62191649
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.60130584
8* ELK3_25401928_ChIP-Seq_HUVEC_Human2.40249909
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25891975
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23941737
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20792487
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.19734899
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.17579348
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10544953
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08468499
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07953858
17* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06528359
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.05427097
19LXR_22292898_ChIP-Seq_THP-1_Human2.04803969
20CLOCK_20551151_ChIP-Seq_293T_Human2.04566842
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99532570
22KDM2B_26808549_Chip-Seq_DND41_Human1.89968334
23VDR_21846776_ChIP-Seq_THP-1_Human1.86912907
24MYC_22102868_ChIP-Seq_BL_Human1.80634266
25* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80567005
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80401102
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79837502
28* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77140925
29RACK7_27058665_Chip-Seq_MCF-7_Human1.75820062
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71387742
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71362321
32TCF7_22412390_ChIP-Seq_EML_Mouse1.68380635
33ATF3_27146783_Chip-Seq_COLON_Human1.68217535
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.66384945
35VDR_24763502_ChIP-Seq_THP-1_Human1.65232065
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63580086
37MAF_26560356_Chip-Seq_TH1_Human1.63170906
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61905230
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59443750
40* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57748915
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56451846
42SPI1_23127762_ChIP-Seq_K562_Human1.54869599
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53650892
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52741759
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.52338208
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50488632
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46865701
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.45753417
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43079144
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43032578
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.41153342
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40298948
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40231707
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39564186
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39564186
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.38769846
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38028029
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38000691
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35954739
60P68_20966046_ChIP-Seq_HELA_Human1.35910843
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34904413
62UTX_26944678_Chip-Seq_JUKART_Human1.34049177
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33263548
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.32670790
65JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32598653
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32366526
67ZNF263_19887448_ChIP-Seq_K562_Human1.31903613
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31738263
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31349692
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31129920
71* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29878621
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.29392897
73MAF_26560356_Chip-Seq_TH2_Human1.29061330
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29029209
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28728950
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27960073
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27564803
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27234563
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26288531
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23808913
81SMC4_20622854_ChIP-Seq_HELA_Human1.23078675
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22078135
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18652939
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17378131
85KDM2B_26808549_Chip-Seq_K562_Human1.17265300
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.16290095
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16115615
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16044787
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15003591
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.14614891
91CJUN_26792858_Chip-Seq_BT549_Human1.14108084
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.14040943
93CREB1_26743006_Chip-Seq_LNCaP_Human1.13173192
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13116693
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.13088703
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12915919
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.12830935
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12552256
99TP53_22127205_ChIP-Seq_IMR90_Human1.11917638
100MYB_26560356_Chip-Seq_TH2_Human1.10761623
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10195171
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09969039
103BCOR_27268052_Chip-Seq_Bcells_Human1.09113048
104* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08791822
105RUNX_20019798_ChIP-Seq_JUKART_Human1.07097480
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06600426
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06240038
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.06214895
109NCOR1_26117541_ChIP-Seq_K562_Human1.06196625
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05497941
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03318741
112SOX2_20726797_ChIP-Seq_SW620_Human1.01271768
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01160591
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01094778
115* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00598428
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00179963
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00101492
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99673633
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99286198
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99046329
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98819862
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98654837
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97742965
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96604779
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96487382
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96176519
127MYB_26560356_Chip-Seq_TH1_Human0.95903952
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.95777312
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.95777312
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.95613623
131BRD4_25478319_ChIP-Seq_HGPS_Human0.94881695
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94539105
133SPI1_23547873_ChIP-Seq_NB4_Human0.94151389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.70519002
2MP0003705_abnormal_hypodermis_morpholog4.53382805
3MP0005275_abnormal_skin_tensile3.31848163
4MP0003303_peritoneal_inflammation3.12733757
5MP0005451_abnormal_body_composition2.90507216
6MP0003566_abnormal_cell_adhesion2.69527992
7MP0003279_aneurysm2.61557961
8MP0001958_emphysema2.57566941
9MP0003300_gastrointestinal_ulcer2.54085166
10MP0008260_abnormal_autophagy2.33548115
11MP0003436_decreased_susceptibility_to2.33325665
12MP0010352_gastrointestinal_tract_polyps2.22497727
13MP0005023_abnormal_wound_healing2.11036579
14MP0005058_abnormal_lysosome_morphology2.07400682
15MP0006054_spinal_hemorrhage1.94568898
16MP0002877_abnormal_melanocyte_morpholog1.94003842
17MP0004510_myositis1.94000661
18MP0003091_abnormal_cell_migration1.93508011
19* MP0004947_skin_inflammation1.79621402
20MP0001533_abnormal_skeleton_physiology1.75461252
21MP0001835_abnormal_antigen_presentation1.68006674
22MP0005409_darkened_coat_color1.67459733
23MP0002060_abnormal_skin_morphology1.66809823
24MP0000685_abnormal_immune_system1.62801893
25MP0010234_abnormal_vibrissa_follicle1.59701673
26MP0009840_abnormal_foam_cell1.59387064
27MP0005000_abnormal_immune_tolerance1.56576396
28MP0002419_abnormal_innate_immunity1.55407986
29MP0009278_abnormal_bone_marrow1.54139416
30MP0009785_altered_susceptibility_to1.52388590
31MP0005076_abnormal_cell_differentiation1.51467905
32MP0003075_altered_response_to1.50913531
33MP0005464_abnormal_platelet_physiology1.50578111
34MP0004272_abnormal_basement_membrane1.49141832
35MP0006082_CNS_inflammation1.48780974
36MP0003045_fibrosis1.48541251
37MP0003191_abnormal_cellular_cholesterol1.47728214
38MP0000858_altered_metastatic_potential1.45103548
39MP0005623_abnormal_meninges_morphology1.41784743
40MP0002998_abnormal_bone_remodeling1.41776656
41MP0005387_immune_system_phenotype1.41592458
42MP0001790_abnormal_immune_system1.41592458
43MP0005503_abnormal_tendon_morphology1.39760437
44MP0004858_abnormal_nervous_system1.38314142
45MP0003828_pulmonary_edema1.37674204
46MP0001243_abnormal_dermal_layer1.35547396
47MP0005257_abnormal_intraocular_pressure1.35141052
48MP0003453_abnormal_keratinocyte_physiol1.33620045
49MP0003448_altered_tumor_morphology1.33594385
50MP0005025_abnormal_response_to1.33413349
51MP0002148_abnormal_hypersensitivity_rea1.32121680
52MP0003724_increased_susceptibility_to1.31861650
53MP0002452_abnormal_antigen_presenting1.30779524
54MP0000343_altered_response_to1.30766719
55MP0000013_abnormal_adipose_tissue1.30668539
56MP0003763_abnormal_thymus_physiology1.29839353
57MP0003329_amyloid_beta_deposits1.28166576
58MP0002396_abnormal_hematopoietic_system1.27740426
59MP0003172_abnormal_lysosome_physiology1.25919995
60MP0002933_joint_inflammation1.22174652
61MP0004264_abnormal_extraembryonic_tissu1.21228955
62MP0000733_abnormal_muscle_development1.17105210
63MP0000537_abnormal_urethra_morphology1.16128641
64MP0002405_respiratory_system_inflammati1.15526316
65MP0002796_impaired_skin_barrier1.14027687
66* MP0002723_abnormal_immune_serum1.11108128
67MP0005390_skeleton_phenotype1.11020543
68MP0002254_reproductive_system_inflammat1.10995324
69MP0000490_abnormal_crypts_of1.10734943
70MP0001800_abnormal_humoral_immune1.09656633
71MP0000467_abnormal_esophagus_morphology1.09422418
72MP0000750_abnormal_muscle_regeneration1.09194876
73MP0000604_amyloidosis1.07846159
74MP0009384_cardiac_valve_regurgitation1.06134844
75MP0001545_abnormal_hematopoietic_system1.05876503
76MP0005397_hematopoietic_system_phenotyp1.05876503
77MP0008004_abnormal_stomach_pH1.04982617
78* MP0001819_abnormal_immune_cell1.04261023
79MP0000767_abnormal_smooth_muscle1.03603515
80* MP0002420_abnormal_adaptive_immunity1.03467978
81MP0002295_abnormal_pulmonary_circulatio1.03018565
82MP0001849_ear_inflammation1.01952266
83MP0000678_abnormal_parathyroid_gland1.01131586
84MP0009333_abnormal_splenocyte_physiolog1.01069835
85MP0004185_abnormal_adipocyte_glucose1.00126467
86MP0001542_abnormal_bone_strength0.99793259
87MP0010155_abnormal_intestine_physiology0.99603962
88* MP0001845_abnormal_inflammatory_respons0.98798464
89MP0001873_stomach_inflammation0.97515428
90MP0004808_abnormal_hematopoietic_stem0.96507127
91MP0005167_abnormal_blood-brain_barrier0.96191214
92MP0000579_abnormal_nail_morphology0.96071410
93MP0001348_abnormal_lacrimal_gland0.95503373
94MP0005166_decreased_susceptibility_to0.94565472
95MP0005621_abnormal_cell_physiology0.93786615
96MP0001216_abnormal_epidermal_layer0.92229042
97MP0002896_abnormal_bone_mineralization0.91890878
98MP0004381_abnormal_hair_follicle0.90895409
99MP0009053_abnormal_anal_canal0.90158986
100MP0000003_abnormal_adipose_tissue0.87416461
101MP0000249_abnormal_blood_vessel0.87324475
102MP0003795_abnormal_bone_structure0.87040040
103MP0001853_heart_inflammation0.84568391
104MP0002166_altered_tumor_susceptibility0.84124953
105MP0010368_abnormal_lymphatic_system0.83767484
106* MP0002398_abnormal_bone_marrow0.83182168
107MP0005164_abnormal_response_to0.82315560
108MP0008961_abnormal_basal_metabolism0.81176700
109MP0002006_tumorigenesis0.80849023
110MP0005501_abnormal_skin_physiology0.80779659
111MP0001851_eye_inflammation0.80184759
112MP0003183_abnormal_peptide_metabolism0.78588492
113MP0005375_adipose_tissue_phenotype0.78368135
114* MP0000716_abnormal_immune_system0.77758012
115MP0002098_abnormal_vibrissa_morphology0.77555734
116MP0010307_abnormal_tumor_latency0.75694407
117* MP0008469_abnormal_protein_level0.74974415
118MP0009931_abnormal_skin_appearance0.74948723
119MP0005310_abnormal_salivary_gland0.74910608
120MP0000751_myopathy0.74869289
121MP0002168_other_aberrant_phenotype0.74866403
122MP0010771_integument_phenotype0.74771561
123MP0000747_muscle_weakness0.73612533
124MP0009764_decreased_sensitivity_to0.73494495
125MP0005666_abnormal_adipose_tissue0.71885370

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.54929172
2Premature rupture of membranes (HP:0001788)5.35301498
3Peritonitis (HP:0002586)4.12977594
4Cerebral aneurysm (HP:0004944)3.98544562
5Atrophic scars (HP:0001075)3.94411758
6Dilatation of the ascending aorta (HP:0005111)3.51466998
7Cervical subluxation (HP:0003308)3.50811982
8Increased connective tissue (HP:0009025)3.41528561
9Ankle contracture (HP:0006466)3.33478637
10Aortic dissection (HP:0002647)3.31912881
11Vertebral compression fractures (HP:0002953)3.30150213
12Broad face (HP:0000283)3.20886423
13Shallow orbits (HP:0000586)3.15689510
14Aortic aneurysm (HP:0004942)3.13681582
15Fragile skin (HP:0001030)3.12907819
16Upper limb amyotrophy (HP:0009129)2.97559932
17Distal upper limb amyotrophy (HP:0007149)2.97559932
18Eczematoid dermatitis (HP:0000976)2.94414793
19Hyperacusis (HP:0010780)2.90190445
20Osteolytic defects of the hand bones (HP:0009699)2.76045757
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.76045757
22Genu recurvatum (HP:0002816)2.74613572
23Achilles tendon contracture (HP:0001771)2.72513110
24Spinal rigidity (HP:0003306)2.63750964
25Increased density of long bones (HP:0006392)2.62333260
26Distal lower limb muscle weakness (HP:0009053)2.61062803
27Mitral valve prolapse (HP:0001634)2.60456442
28Difficulty climbing stairs (HP:0003551)2.54220379
29Type 1 muscle fiber predominance (HP:0003803)2.53961259
30Hand muscle atrophy (HP:0009130)2.53095237
31Soft skin (HP:0000977)2.51595220
32Bladder diverticulum (HP:0000015)2.50020405
33Follicular hyperkeratosis (HP:0007502)2.48445717
34Wormian bones (HP:0002645)2.47506376
35Abnormality of macrophages (HP:0004311)2.47126320
36Interstitial pulmonary disease (HP:0006530)2.44844345
37Abnormality of the Achilles tendon (HP:0005109)2.44617088
38Distal lower limb amyotrophy (HP:0008944)2.38543734
39Dysostosis multiplex (HP:0000943)2.36360985
40Thick nail (HP:0001805)2.36053096
41Urinary glycosaminoglycan excretion (HP:0003541)2.35980580
42Mucopolysacchariduria (HP:0008155)2.35980580
43Increased cerebral lipofuscin (HP:0011813)2.34503390
44Milia (HP:0001056)2.32960306
45Short nail (HP:0001799)2.32221482
46Recurrent abscess formation (HP:0002722)2.32005029
47Aneurysm (HP:0002617)2.31183304
48Flat acetabular roof (HP:0003180)2.29555012
49Vascular tortuosity (HP:0004948)2.28314100
50Blue sclerae (HP:0000592)2.28000544
51Biconcave vertebral bodies (HP:0004586)2.27797880
52Myocardial infarction (HP:0001658)2.23090334
53Frequent falls (HP:0002359)2.20622267
54Axonal loss (HP:0003447)2.18094529
55Elevated erythrocyte sedimentation rate (HP:0003565)2.17478217
56Obstructive sleep apnea (HP:0002870)2.17094663
57Broad metatarsal (HP:0001783)2.16325680
58Neonatal short-limb short stature (HP:0008921)2.14905687
59Abnormality of polysaccharide metabolism (HP:0011012)2.12821990
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12821990
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12821990
62Radial bowing (HP:0002986)2.12614002
63Abnormality of the nasal mucosa (HP:0000433)2.11874036
64Slender build (HP:0001533)2.10609477
65Alopecia of scalp (HP:0002293)2.09594203
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.06807824
67Cellulitis (HP:0100658)2.06645097
68Polygenic inheritance (HP:0010982)2.06216417
69Abnormality of oral frenula (HP:0000190)2.05687937
70Ankyloglossia (HP:0010296)2.04583204
71Elbow flexion contracture (HP:0002987)2.03018612
72Increased IgE level (HP:0003212)2.02520701
73Mildly elevated creatine phosphokinase (HP:0008180)2.02297113
74Abnormality of glycolipid metabolism (HP:0010969)2.00893130
75Abnormality of liposaccharide metabolism (HP:0010968)2.00893130
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.00893130
77Hematochezia (HP:0002573)2.00734962
78Nonimmune hydrops fetalis (HP:0001790)2.00686979
79Ulnar bowing (HP:0003031)2.00532910
80Abnormality of the acetabulum (HP:0003170)2.00276016
81Increased variability in muscle fiber diameter (HP:0003557)1.99889651
82Abnormality of dentin (HP:0010299)1.99029960
83Disproportionate tall stature (HP:0001519)1.97864083
84Joint stiffness (HP:0001387)1.96859042
85Arterial tortuosity (HP:0005116)1.96688846
86Thin bony cortex (HP:0002753)1.96614468
87Nail dystrophy (HP:0008404)1.95846766
88Autoimmune thrombocytopenia (HP:0001973)1.95345102
89Spondylolisthesis (HP:0003302)1.94560237
90Scapular winging (HP:0003691)1.94447369
91Cerebral inclusion bodies (HP:0100314)1.94200525
92Nasal polyposis (HP:0100582)1.93377822
93Abnormality of skeletal muscle fiber size (HP:0012084)1.92515670
94Recurrent bacterial skin infections (HP:0005406)1.92224440
95Systemic lupus erythematosus (HP:0002725)1.92199877
96Gingivitis (HP:0000230)1.91911083
97Lower limb amyotrophy (HP:0007210)1.90920809
98Hemorrhage of the eye (HP:0011885)1.90119477
99Hyperextensible skin (HP:0000974)1.89162767
100Amyloidosis (HP:0011034)1.88874567
101Long toe (HP:0010511)1.88613925
102Wrist flexion contracture (HP:0001239)1.88438579
103Ridged nail (HP:0001807)1.86994664
104Abnormality of the peritoneum (HP:0002585)1.86871869
105Bowed forearm bones (HP:0003956)1.82006038
106Bowing of the arm (HP:0006488)1.82006038
107Long palpebral fissure (HP:0000637)1.81975538
108Camptodactyly of toe (HP:0001836)1.81154846
109Gastrointestinal inflammation (HP:0004386)1.80604704
110Coxa vara (HP:0002812)1.80415124
111Trismus (HP:0000211)1.79761206
112Abnormal blistering of the skin (HP:0008066)1.79307008
113Bowel diverticulosis (HP:0005222)1.78928791
114Emphysema (HP:0002097)1.78656441
115Mitral regurgitation (HP:0001653)1.78623722
116Generalized amyotrophy (HP:0003700)1.78295074
117Loss of speech (HP:0002371)1.77538643
118Stridor (HP:0010307)1.77055923
119Selective tooth agenesis (HP:0001592)1.75449340
120J-shaped sella turcica (HP:0002680)1.75407853
121Striae distensae (HP:0001065)1.74842852
122Hypertriglyceridemia (HP:0002155)1.74280107
123Increased neuronal autofluorescent lipopigment (HP:0002074)1.74155315
124Ulnar deviation of the wrist (HP:0003049)1.72787893
125Recurrent gram-negative bacterial infections (HP:0005420)1.72456709
126Abnormality of the distal phalanges of the toes (HP:0010182)1.72368164
127Asymmetric septal hypertrophy (HP:0001670)1.72256536
128Ectopia lentis (HP:0001083)1.72131139
129Colitis (HP:0002583)1.71923265
130Right ventricular cardiomyopathy (HP:0011663)1.71612717
131Beaking of vertebral bodies (HP:0004568)1.71433973
132Tetraparesis (HP:0002273)1.70992219
133Syringomyelia (HP:0003396)1.70922054
134Spinal cord lesions (HP:0100561)1.70922054
135Insomnia (HP:0100785)1.69963568
136Abnormality of nail color (HP:0100643)1.69941731
137Neurofibrillary tangles (HP:0002185)1.69896044
138Supranuclear gaze palsy (HP:0000605)1.68644389
139Bone pain (HP:0002653)1.67183842
140Abnormality of the thoracic spine (HP:0100711)1.66477134
141Acanthosis nigricans (HP:0000956)1.65822538
142Advanced eruption of teeth (HP:0006288)1.64637988
143Myositis (HP:0100614)1.63853993
144Pustule (HP:0200039)1.63552461
145Natal tooth (HP:0000695)1.63314712
146Neuronal loss in central nervous system (HP:0002529)1.62685169
147Upper motor neuron abnormality (HP:0002127)1.62161397
148Malnutrition (HP:0004395)1.62159037
149Plantar hyperkeratosis (HP:0007556)1.60278147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.00564188
2ERN13.56519841
3TTN3.37265611
4PRPF4B3.23482982
5PKN23.13263950
6SMG12.66705098
7EEF2K2.46230522
8ICK2.05770503
9TBK11.94779255
10LRRK21.92071252
11TESK11.89261534
12DDR21.86684256
13BLK1.83521150
14BMX1.83222637
15MAP2K31.74604016
16RIPK41.68416296
17PDGFRA1.67223757
18PTK61.64823492
19MAP4K11.64177955
20TYK21.63340159
21RIPK11.56447059
22IRAK41.50025331
23JAK31.49298560
24KSR21.44557716
25TAOK11.39983605
26EPHB11.39372192
27JAK11.39267048
28TRPM71.37617560
29TGFBR21.34613182
30PIM21.34591297
31SCYL21.29364692
32PRKD21.28657747
33MAP3K101.25494966
34MAP3K141.25328068
35SIK11.25145514
36TESK21.24570654
37MAP3K31.21986469
38NME21.21431650
39MAP3K111.20457417
40CDK121.20335723
41MST1R1.20248952
42STK101.20017593
43IRAK21.19781401
44DMPK1.19675506
45ZAP701.19405034
46LMTK21.18946644
47MOS1.18833093
48PTK21.18583462
49CAMKK11.18023484
50KIT1.16636067
51MAPKAPK31.15835181
52PAK41.15696553
53MAP3K131.12170421
54KDR1.10860655
55LATS21.08407328
56PAK21.05158572
57PTK2B1.04577269
58MAP3K61.03122146
59FGFR40.99289439
60MARK20.99205741
61HCK0.95750982
62TNK20.92394740
63CSK0.92225309
64CDC42BPA0.89774419
65MAP3K10.88238347
66ARAF0.86043758
67RET0.83802577
68IKBKE0.81424394
69GRK60.79554712
70PRKG20.79090456
71EPHA20.78765966
72ILK0.78073985
73LIMK10.77058716
74PAK60.76689101
75IKBKB0.75070255
76STK380.74564624
77PRKCH0.73031410
78FER0.72876852
79CAMKK20.72458583
80MAP3K80.69063461
81NEK90.68719041
82SIK30.67390189
83PDGFRB0.66728946
84ALK0.65454980
85NTRK10.64292726
86PRKD30.63460486
87FLT30.61900437
88EPHA30.61884964
89BRAF0.61817365
90MAP3K90.60829438
91RPS6KC10.60685024
92RPS6KL10.60685024
93SIK20.60189971
94DAPK30.59052054
95PDK10.58896543
96MAPK110.58509698
97CSF1R0.58380101
98JAK20.58252409
99MET0.57591366
100PDPK10.56749729
101MAP3K20.54855012
102TAOK20.54650186
103ABL20.54375551
104PRKD10.52443451
105MAP2K20.52422436
106IRAK30.52263680
107RAF10.52102711
108EPHB20.52044951
109PIK3CG0.51753715
110BTK0.50720101
111FGFR30.49753164
112MAPK120.49624070
113MAPKAPK20.48491230
114HIPK20.48345504
115FGR0.48223505
116CDK60.47461818
117FES0.45826871
118RPS6KA20.45226127
119CAMK1D0.44303115
120CHUK0.44073184
121MTOR0.43769656
122PAK30.42758567
123CDK40.42148135
124MARK30.41086137
125PAK10.40479989
126* MAP2K10.39868552
127RPS6KA60.37205500
128RPS6KB20.36706504
129MAP3K70.35918109

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.41984884
2Osteoclast differentiation_Homo sapiens_hsa043801.98961336
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.98438507
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83682855
5AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.82414375
6Shigellosis_Homo sapiens_hsa051311.80271054
7Amoebiasis_Homo sapiens_hsa051461.78743718
8Malaria_Homo sapiens_hsa051441.75288845
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.70863040
10Focal adhesion_Homo sapiens_hsa045101.70677186
11Pertussis_Homo sapiens_hsa051331.70352231
12Toxoplasmosis_Homo sapiens_hsa051451.68045570
13ECM-receptor interaction_Homo sapiens_hsa045121.67423292
14Salmonella infection_Homo sapiens_hsa051321.67238128
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64508970
16Tuberculosis_Homo sapiens_hsa051521.64411578
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61489498
18Legionellosis_Homo sapiens_hsa051341.59654703
19Lysosome_Homo sapiens_hsa041421.55240368
20* TNF signaling pathway_Homo sapiens_hsa046681.53138767
21Chronic myeloid leukemia_Homo sapiens_hsa052201.51295783
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.50375398
23Proteoglycans in cancer_Homo sapiens_hsa052051.48007454
24B cell receptor signaling pathway_Homo sapiens_hsa046621.42290697
25VEGF signaling pathway_Homo sapiens_hsa043701.42289144
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39119929
27Notch signaling pathway_Homo sapiens_hsa043301.38882537
28Staphylococcus aureus infection_Homo sapiens_hsa051501.37260628
29Apoptosis_Homo sapiens_hsa042101.36008749
30Platelet activation_Homo sapiens_hsa046111.33742103
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32830923
32Pentose phosphate pathway_Homo sapiens_hsa000301.28704025
33Bladder cancer_Homo sapiens_hsa052191.28497879
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.23971700
35Small cell lung cancer_Homo sapiens_hsa052221.22044320
36Acute myeloid leukemia_Homo sapiens_hsa052211.18625744
37Antigen processing and presentation_Homo sapiens_hsa046121.15564277
38Phagosome_Homo sapiens_hsa041451.13782139
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.12726712
40Fructose and mannose metabolism_Homo sapiens_hsa000511.10620277
41Measles_Homo sapiens_hsa051621.10021294
42Galactose metabolism_Homo sapiens_hsa000521.09539835
43Thyroid cancer_Homo sapiens_hsa052161.07373411
44Pancreatic cancer_Homo sapiens_hsa052121.06299915
45Adipocytokine signaling pathway_Homo sapiens_hsa049201.05812586
46Other glycan degradation_Homo sapiens_hsa005111.05530328
47Chemokine signaling pathway_Homo sapiens_hsa040621.05218046
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04403233
49Influenza A_Homo sapiens_hsa051641.04387293
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04274125
51Hepatitis B_Homo sapiens_hsa051611.00752019
52Adherens junction_Homo sapiens_hsa045201.00611639
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00098658
54ErbB signaling pathway_Homo sapiens_hsa040120.99645502
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99130931
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98882251
57Viral myocarditis_Homo sapiens_hsa054160.97521287
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95435185
59Glioma_Homo sapiens_hsa052140.95229880
60HIF-1 signaling pathway_Homo sapiens_hsa040660.92723335
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89968776
62Dilated cardiomyopathy_Homo sapiens_hsa054140.88535224
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.87841572
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87316610
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86724882
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85842332
67Endocytosis_Homo sapiens_hsa041440.85803286
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.84337023
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84034354
70Prolactin signaling pathway_Homo sapiens_hsa049170.82361352
71Insulin resistance_Homo sapiens_hsa049310.80836854
72Inositol phosphate metabolism_Homo sapiens_hsa005620.80257719
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79546712
74Hematopoietic cell lineage_Homo sapiens_hsa046400.78885154
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77926544
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77791007
77Rap1 signaling pathway_Homo sapiens_hsa040150.76519424
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75517691
79Prion diseases_Homo sapiens_hsa050200.74344911
80Non-small cell lung cancer_Homo sapiens_hsa052230.74324301
81Vibrio cholerae infection_Homo sapiens_hsa051100.73887503
82Rheumatoid arthritis_Homo sapiens_hsa053230.73684182
83Protein digestion and absorption_Homo sapiens_hsa049740.71871714
84Choline metabolism in cancer_Homo sapiens_hsa052310.71432865
85mTOR signaling pathway_Homo sapiens_hsa041500.71029945
86Herpes simplex infection_Homo sapiens_hsa051680.70631706
87T cell receptor signaling pathway_Homo sapiens_hsa046600.69671655
88African trypanosomiasis_Homo sapiens_hsa051430.69619449
89Colorectal cancer_Homo sapiens_hsa052100.69605080
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66814344
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66633797
92Hepatitis C_Homo sapiens_hsa051600.66185980
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.66032782
94MicroRNAs in cancer_Homo sapiens_hsa052060.65816654
95Prostate cancer_Homo sapiens_hsa052150.64683243
96Long-term potentiation_Homo sapiens_hsa047200.63627012
97GnRH signaling pathway_Homo sapiens_hsa049120.63480587
98Estrogen signaling pathway_Homo sapiens_hsa049150.62730621
99Renal cell carcinoma_Homo sapiens_hsa052110.62497124
100Graft-versus-host disease_Homo sapiens_hsa053320.62451220
101Caffeine metabolism_Homo sapiens_hsa002320.62351087
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62031011
103HTLV-I infection_Homo sapiens_hsa051660.58737521
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.57484167
105AMPK signaling pathway_Homo sapiens_hsa041520.57482858
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56458488
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54949714
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54842529
109Type II diabetes mellitus_Homo sapiens_hsa049300.54558164
110Pathways in cancer_Homo sapiens_hsa052000.53547257
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53441277
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53426819
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51542995
114Endometrial cancer_Homo sapiens_hsa052130.51037902
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50754850
116Viral carcinogenesis_Homo sapiens_hsa052030.50352747
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47927796
118Insulin signaling pathway_Homo sapiens_hsa049100.46692792
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46675348
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46557359

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