RPS6KA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.21164389
2axon ensheathment in central nervous system (GO:0032291)4.78111081
3central nervous system myelination (GO:0022010)4.78111081
4response to pheromone (GO:0019236)4.69625299
5glycoprotein catabolic process (GO:0006516)4.38635044
6megakaryocyte development (GO:0035855)4.26106047
7tryptophan catabolic process (GO:0006569)4.03066385
8indole-containing compound catabolic process (GO:0042436)4.03066385
9indolalkylamine catabolic process (GO:0046218)4.03066385
10kynurenine metabolic process (GO:0070189)3.94252188
11microtubule nucleation (GO:0007020)3.79547930
12indolalkylamine metabolic process (GO:0006586)3.78324725
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.70694761
14establishment of integrated proviral latency (GO:0075713)3.70667809
15nonmotile primary cilium assembly (GO:0035058)3.67883020
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.65867790
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.65867790
18regulation of translation, ncRNA-mediated (GO:0045974)3.65867790
19serotonin metabolic process (GO:0042428)3.56914719
20Golgi to endosome transport (GO:0006895)3.56283470
21primary amino compound metabolic process (GO:1901160)3.55765950
22tryptophan metabolic process (GO:0006568)3.49910646
23negative regulation of circadian rhythm (GO:0042754)3.49296386
24DNA replication checkpoint (GO:0000076)3.46479869
25cytoplasmic mRNA processing body assembly (GO:0033962)3.44071573
26cilium or flagellum-dependent cell motility (GO:0001539)3.43268095
27indole-containing compound metabolic process (GO:0042430)3.39927246
28centrosome duplication (GO:0051298)3.38967086
29sulfation (GO:0051923)3.36501931
30mitotic sister chromatid cohesion (GO:0007064)3.30887523
31DNA deamination (GO:0045006)3.29334105
32detection of light stimulus involved in sensory perception (GO:0050962)3.29329015
33detection of light stimulus involved in visual perception (GO:0050908)3.29329015
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.28531136
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27376371
36neural tube formation (GO:0001841)3.24631393
37neuronal action potential (GO:0019228)3.24394728
38nerve growth factor signaling pathway (GO:0038180)3.19363615
39interkinetic nuclear migration (GO:0022027)3.14396618
40synaptic vesicle exocytosis (GO:0016079)3.14333764
41L-amino acid import (GO:0043092)3.13070083
42cellular ketone body metabolic process (GO:0046950)3.12670752
43negative regulation of dendrite development (GO:2000171)3.11755589
44regulation of hippo signaling (GO:0035330)3.08484738
45positive regulation of gene expression, epigenetic (GO:0045815)3.07171572
46mRNA splice site selection (GO:0006376)3.05937540
47protein localization to microtubule cytoskeleton (GO:0072698)3.01158877
48negative regulation of neurotransmitter transport (GO:0051589)3.01044614
49regulation of collateral sprouting (GO:0048670)2.99143817
50NAD biosynthetic process (GO:0009435)2.95737232
51regulation of synapse structural plasticity (GO:0051823)2.94722628
52cellular response to exogenous dsRNA (GO:0071360)2.92170634
53epithelial cilium movement (GO:0003351)2.90923404
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90491940
55rRNA catabolic process (GO:0016075)2.88954763
56regulation of gene silencing by RNA (GO:0060966)2.86715424
57regulation of posttranscriptional gene silencing (GO:0060147)2.86715424
58regulation of gene silencing by miRNA (GO:0060964)2.86715424
59kidney morphogenesis (GO:0060993)2.85574624
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84472324
61spinal cord motor neuron differentiation (GO:0021522)2.83879816
62synaptic vesicle maturation (GO:0016188)2.82342731
63cilium movement (GO:0003341)2.82158390
64adenosine receptor signaling pathway (GO:0001973)2.79891010
65membrane depolarization during action potential (GO:0086010)2.79817998
66positive regulation of defense response to virus by host (GO:0002230)2.78557822
67axoneme assembly (GO:0035082)2.77899322
68ketone body metabolic process (GO:1902224)2.77644290
69piRNA metabolic process (GO:0034587)2.77512585
70negative regulation of transcription by competitive promoter binding (GO:0010944)2.75910219
71behavioral response to ethanol (GO:0048149)2.73358584
72reciprocal meiotic recombination (GO:0007131)2.73170725
73reciprocal DNA recombination (GO:0035825)2.73170725
74positive regulation of cell cycle checkpoint (GO:1901978)2.72417493
75negative regulation of telomere maintenance (GO:0032205)2.72399922
76regulation of action potential (GO:0098900)2.70051997
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70051396
78positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.69909982
79protein K11-linked deubiquitination (GO:0035871)2.69331703
80negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68775838
81microtubule polymerization or depolymerization (GO:0031109)2.65973459
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65712273
83reflex (GO:0060004)2.65668012
84positive regulation of sodium ion transmembrane transport (GO:1902307)2.64531711
85prepulse inhibition (GO:0060134)2.63790529
86protein polyglutamylation (GO:0018095)2.62786198
87long-term memory (GO:0007616)2.62530904
88negative regulation of reactive oxygen species metabolic process (GO:2000378)2.60953768
89protein K48-linked deubiquitination (GO:0071108)2.60567127
90myelin maintenance (GO:0043217)2.60392235
91neuronal action potential propagation (GO:0019227)2.59630713
92protein import into peroxisome matrix (GO:0016558)2.59486753
93substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.59339523
94substrate-independent telencephalic tangential migration (GO:0021826)2.59339523
95negative regulation of systemic arterial blood pressure (GO:0003085)2.59061349
96cellular response to ATP (GO:0071318)2.58827079
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58825155
98mechanosensory behavior (GO:0007638)2.57807767
99peristalsis (GO:0030432)2.57467775
100somite development (GO:0061053)2.56469916
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.55661592
102regulation of mesoderm development (GO:2000380)2.55105095
103presynaptic membrane organization (GO:0097090)2.54964521
104negative regulation of mast cell activation (GO:0033004)2.54640549
105nephron epithelium morphogenesis (GO:0072088)2.54257240
106nephron tubule morphogenesis (GO:0072078)2.54257240
107fucosylation (GO:0036065)2.53569564
108lymphoid progenitor cell differentiation (GO:0002320)2.52914881
109negative regulation of neurotransmitter secretion (GO:0046929)2.52826388
110multicellular organism reproduction (GO:0032504)2.52679965
111locomotory exploration behavior (GO:0035641)2.52542014
112retinal cone cell development (GO:0046549)2.52108334
113oxidative demethylation (GO:0070989)2.50086267
114action potential (GO:0001508)2.49741531
115phosphatidylinositol acyl-chain remodeling (GO:0036149)2.49686131
116atrial cardiac muscle cell action potential (GO:0086014)2.48499359
117adult walking behavior (GO:0007628)2.48498627
118establishment of viral latency (GO:0019043)2.46265756
119microtubule organizing center organization (GO:0031023)2.45538959
120myelination (GO:0042552)2.45441725
121positive regulation of oligodendrocyte differentiation (GO:0048714)2.44929709
122cilium organization (GO:0044782)2.43927884
123urinary tract smooth muscle contraction (GO:0014848)2.43199757
124positive regulation of translational initiation (GO:0045948)2.42623928
125L-fucose metabolic process (GO:0042354)2.42273925
126L-fucose catabolic process (GO:0042355)2.42273925
127fucose catabolic process (GO:0019317)2.42273925
128amine catabolic process (GO:0009310)2.42094184
129cellular biogenic amine catabolic process (GO:0042402)2.42094184
130cornea development in camera-type eye (GO:0061303)2.41881948
131protein K63-linked deubiquitination (GO:0070536)2.41203042
132ensheathment of neurons (GO:0007272)2.40743672
133axon ensheathment (GO:0008366)2.40743672
134centrosome organization (GO:0051297)2.40742396
135positive regulation of fatty acid oxidation (GO:0046321)2.40635325
136positive regulation of Rap GTPase activity (GO:0032854)2.40246356
137ionotropic glutamate receptor signaling pathway (GO:0035235)2.39404727
138myeloid cell development (GO:0061515)2.39154547
139parturition (GO:0007567)2.38690192
140response to methylmercury (GO:0051597)2.37319753
141synaptic transmission, cholinergic (GO:0007271)2.37198216
142cyclic nucleotide catabolic process (GO:0009214)2.36924417
143presynaptic membrane assembly (GO:0097105)2.36629356
144cardiovascular system development (GO:0072358)2.36166798
145regulation of Rap GTPase activity (GO:0032317)2.36047178
146regulation of pigment cell differentiation (GO:0050932)2.35849243
147cilium assembly (GO:0042384)2.35810480
148snRNA transcription (GO:0009301)2.34469193
149glycine transport (GO:0015816)2.34398617
150regulation of excitatory postsynaptic membrane potential (GO:0060079)2.34077176
151regulation of rhodopsin mediated signaling pathway (GO:0022400)2.34004632
152regulation of voltage-gated calcium channel activity (GO:1901385)2.33807618
153regulation of dendritic spine morphogenesis (GO:0061001)2.33670308
154protein localization to cytoskeleton (GO:0044380)2.33566852
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.33331206
156regulation of glutamate receptor signaling pathway (GO:1900449)2.32229624
157postsynaptic membrane organization (GO:0001941)2.31460312
158DNA methylation involved in gamete generation (GO:0043046)2.30698085
159rhodopsin mediated signaling pathway (GO:0016056)2.30668442
160startle response (GO:0001964)2.30631473
161neural tube development (GO:0021915)2.30180614
162auditory behavior (GO:0031223)2.29874489
163long-chain fatty acid biosynthetic process (GO:0042759)2.29598815
164positive regulation of receptor activity (GO:2000273)2.29241795
165intra-S DNA damage checkpoint (GO:0031573)2.28495453
166cAMP catabolic process (GO:0006198)2.27948258
167positive regulation of membrane potential (GO:0045838)2.27621702
168positive regulation of granulocyte differentiation (GO:0030854)2.27370770
169membrane tubulation (GO:0097320)2.27056464
170negative regulation of fibroblast apoptotic process (GO:2000270)2.26933637
171neuron-neuron synaptic transmission (GO:0007270)2.26932134
172mast cell activation (GO:0045576)2.25103271
173synaptic transmission, glutamatergic (GO:0035249)2.24778350
174mast cell activation involved in immune response (GO:0002279)2.24589182
175mast cell degranulation (GO:0043303)2.24589182
176negative regulation of DNA-dependent DNA replication (GO:2000104)2.23946388
177regulation of dendritic spine development (GO:0060998)2.22256211
178astrocyte development (GO:0014002)2.22224827
179neuromuscular process controlling balance (GO:0050885)2.20445660
180peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.20409433
181gamma-aminobutyric acid transport (GO:0015812)2.19734972
182negative regulation of necroptotic process (GO:0060546)2.19733770
183definitive hemopoiesis (GO:0060216)2.19187992
184G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.17592422
185positive regulation of neurotransmitter secretion (GO:0001956)2.16580837
186transmission of nerve impulse (GO:0019226)2.16358306
187negative regulation of protein oligomerization (GO:0032460)2.16312573
188establishment of mitochondrion localization (GO:0051654)2.16213993
189alternative mRNA splicing, via spliceosome (GO:0000380)2.15518793

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.15092182
2ZNF274_21170338_ChIP-Seq_K562_Hela3.65382391
3GBX2_23144817_ChIP-Seq_PC3_Human3.03044008
4VDR_22108803_ChIP-Seq_LS180_Human2.95498717
5EZH2_22144423_ChIP-Seq_EOC_Human2.74468524
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67000537
7SCL_19346495_ChIP-Seq_HPC-7_Human2.55875928
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.33291748
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31289300
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27532613
11IGF1R_20145208_ChIP-Seq_DFB_Human2.27086060
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21273537
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18798222
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16252378
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12160762
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12037664
17* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10171233
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09795566
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09289943
20TAF15_26573619_Chip-Seq_HEK293_Human2.08986720
21FUS_26573619_Chip-Seq_HEK293_Human2.05162957
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.01590118
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.98278163
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97080060
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.96904323
26AR_21572438_ChIP-Seq_LNCaP_Human1.90704127
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84251304
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.83601166
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76884284
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76760538
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69476185
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65954381
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61719512
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.60789144
35* RUNX_20019798_ChIP-Seq_JUKART_Human1.60077055
36EWS_26573619_Chip-Seq_HEK293_Human1.56518432
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56312178
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.56301109
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56301109
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.54642538
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53998033
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.53877007
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.51611545
44BCAT_22108803_ChIP-Seq_LS180_Human1.50559812
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49312681
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.47862605
47IRF1_19129219_ChIP-ChIP_H3396_Human1.47391102
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46563474
49AR_25329375_ChIP-Seq_VCAP_Human1.46551432
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46012136
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44253166
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44244635
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42152733
54DROSHA_22980978_ChIP-Seq_HELA_Human1.41127528
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39921430
56* STAT3_23295773_ChIP-Seq_U87_Human1.39139179
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38752465
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37714994
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36467373
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35863501
61TP53_16413492_ChIP-PET_HCT116_Human1.35748250
62TCF4_23295773_ChIP-Seq_U87_Human1.34153321
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33422558
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32681448
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32347991
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30979938
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30184287
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.30099896
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29850282
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29448598
71CBP_20019798_ChIP-Seq_JUKART_Human1.29448598
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25936063
73SPI1_23127762_ChIP-Seq_K562_Human1.24882878
74RUNX2_22187159_ChIP-Seq_PCA_Human1.24609634
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.24100575
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23564017
77* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23420352
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23347823
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.20715072
80ER_23166858_ChIP-Seq_MCF-7_Human1.20120653
81TCF4_22108803_ChIP-Seq_LS180_Human1.19836798
82RNF2_27304074_Chip-Seq_NSC_Mouse1.19646528
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19082807
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.19059883
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19019545
86* TP53_22573176_ChIP-Seq_HFKS_Human1.17518976
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17434281
88E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17271793
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17178987
90P300_19829295_ChIP-Seq_ESCs_Human1.15829393
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.14844211
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.14656596
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14656596
94* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14142246
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.12713782
96SOX2_19829295_ChIP-Seq_ESCs_Human1.12677660
97NANOG_19829295_ChIP-Seq_ESCs_Human1.12677660
98AHR_22903824_ChIP-Seq_MCF-7_Human1.12451041
99VDR_24763502_ChIP-Seq_THP-1_Human1.10656105
100REST_21632747_ChIP-Seq_MESCs_Mouse1.10533293
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09931145
102* GATA3_21878914_ChIP-Seq_MCF-7_Human1.09919354
103JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09892522
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.09423941
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08849831
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.08804173
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08787682
108SMAD4_21799915_ChIP-Seq_A2780_Human1.08351154
109JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08344001
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.07894597
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06772872
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05561588
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04221383
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03145573
115EED_16625203_ChIP-ChIP_MESCs_Mouse1.02931574
116VDR_24787735_ChIP-Seq_THP-1_Human1.01681463
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00268891
118* HOXB7_26014856_ChIP-Seq_BT474_Human0.99600988
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.99534648
120E2F1_18555785_Chip-Seq_ESCs_Mouse0.99396088
121RXR_22108803_ChIP-Seq_LS180_Human0.99202334
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.98993754
123EGR1_19374776_ChIP-ChIP_THP-1_Human0.98751777
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98578811
125* MYB_26560356_Chip-Seq_TH2_Human0.98283615
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97489673
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97233821
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97204513
129P300_18555785_Chip-Seq_ESCs_Mouse0.95671059
130TCF7_22412390_ChIP-Seq_EML_Mouse0.95269817
131* SOX2_21211035_ChIP-Seq_LN229_Gbm0.93925918
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93268041
133NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92867357
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92547104
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92472635
136* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92203199
137RNF2_27304074_Chip-Seq_ESCs_Mouse0.92187391
138GATA3_27048872_Chip-Seq_THYMUS_Human0.91668064
139P53_22387025_ChIP-Seq_ESCs_Mouse0.90283751
140TAL1_26923725_Chip-Seq_HPCs_Mouse0.89520785
141PU_27001747_Chip-Seq_BMDM_Mouse0.89183713
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88625312
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.87823100
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87617466
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.86966598
146DPY_21335234_ChIP-Seq_ESCs_Mouse0.86436628
147MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85769864
148REST_18959480_ChIP-ChIP_MESCs_Mouse0.85061216
149SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.84375393
150KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84339502
151* FLI1_21867929_ChIP-Seq_TH2_Mouse0.84157541
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83213072
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82484142
154GATA1_19941826_ChIP-Seq_K562_Human0.82331541
155DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81545228
156SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81151807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.72990343
2MP0003646_muscle_fatigue3.00324390
3MP0003195_calcinosis2.79165556
4MP0002822_catalepsy2.67716638
5MP0005423_abnormal_somatic_nervous2.56341528
6MP0000920_abnormal_myelination2.54526250
7MP0004270_analgesia2.51075487
8MP0003635_abnormal_synaptic_transmissio2.49580470
9MP0003136_yellow_coat_color2.44653747
10MP0004043_abnormal_pH_regulation2.44422894
11MP0001486_abnormal_startle_reflex2.36074210
12MP0003880_abnormal_central_pattern2.31346274
13MP0005551_abnormal_eye_electrophysiolog2.30978386
14MP0003943_abnormal_hepatobiliary_system2.22922915
15MP0009046_muscle_twitch2.21698077
16* MP0009745_abnormal_behavioral_response2.16122762
17MP0003283_abnormal_digestive_organ2.12744932
18MP0002064_seizures2.09141526
19MP0002102_abnormal_ear_morphology2.08370588
20MP0002653_abnormal_ependyma_morphology2.06918730
21MP0004808_abnormal_hematopoietic_stem1.99679630
22MP0002272_abnormal_nervous_system1.98916889
23MP0000427_abnormal_hair_cycle1.97499594
24MP0001851_eye_inflammation1.97158637
25MP0004147_increased_porphyrin_level1.93288557
26MP0004130_abnormal_muscle_cell1.88235616
27* MP0002063_abnormal_learning/memory/cond1.85277096
28MP0002396_abnormal_hematopoietic_system1.84853858
29MP0005409_darkened_coat_color1.84156169
30MP0005171_absent_coat_pigmentation1.83069608
31MP0008872_abnormal_physiological_respon1.82340493
32MP0005646_abnormal_pituitary_gland1.81335095
33MP0001188_hyperpigmentation1.79209704
34MP0002735_abnormal_chemical_nociception1.75749168
35MP0002638_abnormal_pupillary_reflex1.70304364
36MP0003690_abnormal_glial_cell1.69816230
37MP0001849_ear_inflammation1.69768978
38MP0008569_lethality_at_weaning1.69660625
39MP0010678_abnormal_skin_adnexa1.66644576
40MP0002572_abnormal_emotion/affect_behav1.66204253
41MP0004145_abnormal_muscle_electrophysio1.64955532
42MP0001835_abnormal_antigen_presentation1.60369954
43MP0008877_abnormal_DNA_methylation1.58539495
44MP0004885_abnormal_endolymph1.58444769
45MP0003763_abnormal_thymus_physiology1.56231387
46MP0010094_abnormal_chromosome_stability1.55983516
47MP0002876_abnormal_thyroid_physiology1.55974179
48MP0001968_abnormal_touch/_nociception1.53063781
49MP0003632_abnormal_nervous_system1.51596728
50MP0002734_abnormal_mechanical_nocicepti1.46038728
51MP0000569_abnormal_digit_pigmentation1.46024741
52MP0005645_abnormal_hypothalamus_physiol1.45084896
53MP0002398_abnormal_bone_marrow1.44825304
54MP0003878_abnormal_ear_physiology1.42531439
55MP0005377_hearing/vestibular/ear_phenot1.42531439
56MP0000383_abnormal_hair_follicle1.42149800
57MP0002736_abnormal_nociception_after1.42109569
58MP0000631_abnormal_neuroendocrine_gland1.41275117
59MP0003631_nervous_system_phenotype1.38628293
60MP0004924_abnormal_behavior1.38042277
61MP0005386_behavior/neurological_phenoty1.38042277
62MP0002837_dystrophic_cardiac_calcinosis1.36876763
63MP0005075_abnormal_melanosome_morpholog1.36262072
64MP0006292_abnormal_olfactory_placode1.35362397
65MP0001529_abnormal_vocalization1.33362401
66MP0005167_abnormal_blood-brain_barrier1.30089651
67MP0002928_abnormal_bile_duct1.29492379
68MP0002067_abnormal_sensory_capabilities1.29036495
69MP0001986_abnormal_taste_sensitivity1.28755573
70MP0005253_abnormal_eye_physiology1.27488244
71MP0008057_abnormal_DNA_replication1.25742199
72MP0008875_abnormal_xenobiotic_pharmacok1.24002770
73MP0006276_abnormal_autonomic_nervous1.22992633
74MP0002160_abnormal_reproductive_system1.22628869
75MP0001800_abnormal_humoral_immune1.22377178
76MP0003633_abnormal_nervous_system1.22138234
77MP0004133_heterotaxia1.20294713
78MP0004811_abnormal_neuron_physiology1.20028676
79MP0000955_abnormal_spinal_cord1.19491877
80MP0001819_abnormal_immune_cell1.19292583
81MP0002420_abnormal_adaptive_immunity1.19121151
82MP0005389_reproductive_system_phenotype1.18996557
83MP0000465_gastrointestinal_hemorrhage1.18655451
84MP0008961_abnormal_basal_metabolism1.17156912
85MP0005671_abnormal_response_to1.15296409
86MP0004742_abnormal_vestibular_system1.13616718
87MP0008874_decreased_physiological_sensi1.13058854
88MP0000716_abnormal_immune_system1.12893708
89MP0005174_abnormal_tail_pigmentation1.12491090
90MP0001970_abnormal_pain_threshold1.12397403
91MP0005464_abnormal_platelet_physiology1.10289477
92MP0010386_abnormal_urinary_bladder1.10286498
93MP0002723_abnormal_immune_serum1.09760034
94MP0002229_neurodegeneration1.08287943
95MP0002452_abnormal_antigen_presenting1.07929155
96MP0003950_abnormal_plasma_membrane1.04886268
97MP0000778_abnormal_nervous_system1.04720833
98MP0001919_abnormal_reproductive_system1.03736133
99MP0003077_abnormal_cell_cycle1.03669006
100MP0003634_abnormal_glial_cell1.03003339
101MP0000703_abnormal_thymus_morphology1.02805425
102MP0001545_abnormal_hematopoietic_system1.02380522
103MP0005397_hematopoietic_system_phenotyp1.02380522
104MP0010307_abnormal_tumor_latency1.02241407
105MP0002277_abnormal_respiratory_mucosa1.02162546
106MP0003828_pulmonary_edema1.02160533
107MP0003300_gastrointestinal_ulcer1.02000767
108MP0003787_abnormal_imprinting1.01907204
109MP0001485_abnormal_pinna_reflex1.01125905
110MP0000230_abnormal_systemic_arterial1.00863365
111MP0002066_abnormal_motor_capabilities/c0.98738082
112MP0001905_abnormal_dopamine_level0.98360461
113MP0004510_myositis0.96290713
114MP0003137_abnormal_impulse_conducting0.95892289
115MP0000689_abnormal_spleen_morphology0.95780901
116MP0002095_abnormal_skin_pigmentation0.95169532
117MP0003329_amyloid_beta_deposits0.94405813
118MP0003890_abnormal_embryonic-extraembry0.93910135
119MP0002557_abnormal_social/conspecific_i0.93733595
120MP0002882_abnormal_neuron_morphology0.93207146
121MP0002938_white_spotting0.93167110
122MP0004142_abnormal_muscle_tone0.93159082
123MP0002733_abnormal_thermal_nociception0.92933961
124MP0005195_abnormal_posterior_eye0.92576584
125MP0005000_abnormal_immune_tolerance0.91972764
126MP0003111_abnormal_nucleus_morphology0.91843852
127MP0000372_irregular_coat_pigmentation0.90521913
128MP0005448_abnormal_energy_balance0.89924800
129MP0002234_abnormal_pharynx_morphology0.89497764
130MP0002419_abnormal_innate_immunity0.89049214
131MP0006072_abnormal_retinal_apoptosis0.88454544
132MP0004215_abnormal_myocardial_fiber0.88270880
133MP0003172_abnormal_lysosome_physiology0.88153289
134MP0001501_abnormal_sleep_pattern0.88122805
135MP0002429_abnormal_blood_cell0.87813157
136MP0000470_abnormal_stomach_morphology0.86824083
137MP0003045_fibrosis0.85839635
138MP0000026_abnormal_inner_ear0.84038854
139MP0002152_abnormal_brain_morphology0.83928557
140MP0001177_atelectasis0.83920210
141MP0003075_altered_response_to0.83274193
142MP0001664_abnormal_digestion0.82851866
143MP0003119_abnormal_digestive_system0.82808758
144MP0001963_abnormal_hearing_physiology0.82460036
145MP0003698_abnormal_male_reproductive0.81596188
146MP0001873_stomach_inflammation0.81420714
147MP0001440_abnormal_grooming_behavior0.81049779
148MP0002722_abnormal_immune_system0.79023199
149MP0005085_abnormal_gallbladder_physiolo0.78977103
150MP0009785_altered_susceptibility_to0.78488031
151MP0002075_abnormal_coat/hair_pigmentati0.77529237
152MP0002752_abnormal_somatic_nervous0.76278138
153MP0002184_abnormal_innervation0.75447256
154MP0001790_abnormal_immune_system0.75191729
155MP0001502_abnormal_circadian_rhythm0.74849697
156MP0001324_abnormal_eye_pigmentation0.72592626
157MP0001765_abnormal_ion_homeostasis0.71044194
158MP0005266_abnormal_metabolism0.70715138
159MP0000538_abnormal_urinary_bladder0.70281427

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.57183237
2Genetic anticipation (HP:0003743)4.20974321
3Mutism (HP:0002300)3.98812483
4Congenital stationary night blindness (HP:0007642)3.91534330
5Nephronophthisis (HP:0000090)3.69934922
6Focal motor seizures (HP:0011153)3.63105453
7Molar tooth sign on MRI (HP:0002419)3.60666988
8Abnormality of midbrain morphology (HP:0002418)3.60666988
9Myokymia (HP:0002411)3.60404204
10Disinhibition (HP:0000734)3.37769096
11Acute lymphatic leukemia (HP:0006721)3.34395080
12Action tremor (HP:0002345)3.32804752
13Abnormality of the renal cortex (HP:0011035)3.30341211
14Abnormality of the renal medulla (HP:0100957)3.28358176
15Inappropriate behavior (HP:0000719)3.25865127
16Abnormality of alanine metabolism (HP:0010916)3.24716100
17Hyperalaninemia (HP:0003348)3.24716100
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.24716100
19Trigonocephaly (HP:0000243)3.16988591
20Visual hallucinations (HP:0002367)3.15075580
21Attenuation of retinal blood vessels (HP:0007843)3.12539013
22Chronic hepatic failure (HP:0100626)3.04666118
23Chronic otitis media (HP:0000389)2.99531711
24Tubular atrophy (HP:0000092)2.98810131
25Inability to walk (HP:0002540)2.96712051
26Type II lissencephaly (HP:0007260)2.96464321
27Epileptic encephalopathy (HP:0200134)2.88275377
28Patellar aplasia (HP:0006443)2.88171335
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.86669428
30Absent/shortened dynein arms (HP:0200106)2.86669428
31Abnormality of the fingertips (HP:0001211)2.84339536
32B lymphocytopenia (HP:0010976)2.82067561
33Abnormality of B cell number (HP:0010975)2.82067561
34Cystic liver disease (HP:0006706)2.81200555
35Clumsiness (HP:0002312)2.80853109
36Large for gestational age (HP:0001520)2.76579988
37Loss of speech (HP:0002371)2.74494062
38Broad-based gait (HP:0002136)2.71993729
39Decreased circulating renin level (HP:0003351)2.71892936
40Aplasia/Hypoplasia of the patella (HP:0006498)2.70248497
41Polydipsia (HP:0001959)2.68429356
42Abnormal drinking behavior (HP:0030082)2.68429356
43Intention tremor (HP:0002080)2.67256480
44Papilledema (HP:0001085)2.57256712
45Dysmetria (HP:0001310)2.56042285
46Medial flaring of the eyebrow (HP:0010747)2.55779207
47Protruding tongue (HP:0010808)2.54835539
48Furrowed tongue (HP:0000221)2.54716187
49Aqueductal stenosis (HP:0002410)2.53349425
50Febrile seizures (HP:0002373)2.45724316
51Abnormality of the corticospinal tract (HP:0002492)2.45327413
52Stomach cancer (HP:0012126)2.43045261
53Abolished electroretinogram (ERG) (HP:0000550)2.42977274
54Ankle clonus (HP:0011448)2.41481612
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.40779827
56Macroorchidism (HP:0000053)2.39109344
57Lower limb amyotrophy (HP:0007210)2.38213883
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38145101
59Fair hair (HP:0002286)2.37465190
60Absent frontal sinuses (HP:0002688)2.36816007
61Congenital, generalized hypertrichosis (HP:0004540)2.36712032
62Duplicated collecting system (HP:0000081)2.34978585
63Concave nail (HP:0001598)2.34691719
64Decreased central vision (HP:0007663)2.32709254
65Gaze-evoked nystagmus (HP:0000640)2.29867997
66Abnormality of the periventricular white matter (HP:0002518)2.28143156
67Small hand (HP:0200055)2.26332150
68Postural instability (HP:0002172)2.25993218
69Focal seizures (HP:0007359)2.25918909
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24064370
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.24064370
72Abnormality of chromosome stability (HP:0003220)2.23392776
73Pendular nystagmus (HP:0012043)2.23003786
74Neurodegeneration (HP:0002180)2.22754887
75Lissencephaly (HP:0001339)2.22151281
76Sclerocornea (HP:0000647)2.21822264
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.20862689
78Spastic gait (HP:0002064)2.20162982
79Abnormal ciliary motility (HP:0012262)2.20162633
80Abnormal respiratory motile cilium morphology (HP:0005938)2.19658477
81Abnormal respiratory epithelium morphology (HP:0012253)2.19658477
82Clubbing of toes (HP:0100760)2.18971659
83Onion bulb formation (HP:0003383)2.17352497
84Poor eye contact (HP:0000817)2.17241409
85Chromsome breakage (HP:0040012)2.16829437
86Acute myeloid leukemia (HP:0004808)2.14927379
87Progressive cerebellar ataxia (HP:0002073)2.14773132
88Slow saccadic eye movements (HP:0000514)2.14659095
89Abnormality of the renal collecting system (HP:0004742)2.14107644
90Termporal pattern (HP:0011008)2.12940857
91Insidious onset (HP:0003587)2.12940857
92Chorioretinal atrophy (HP:0000533)2.11612641
93Resting tremor (HP:0002322)2.11410630
94Dysdiadochokinesis (HP:0002075)2.09124012
95Abnormal rod and cone electroretinograms (HP:0008323)2.08515938
96Generalized hypopigmentation of hair (HP:0011358)2.07775269
97Congenital hepatic fibrosis (HP:0002612)2.07290333
98Partial agenesis of the corpus callosum (HP:0001338)2.06936716
99Polyuria (HP:0000103)2.06927027
100Peripheral hypomyelination (HP:0007182)2.06634114
101Keratoconus (HP:0000563)2.05624447
102Increased corneal curvature (HP:0100692)2.05624447
103IgM deficiency (HP:0002850)2.04998517
104Absent speech (HP:0001344)2.03662005
105Apathy (HP:0000741)2.03022587
106Cerebellar dysplasia (HP:0007033)2.02409764
107Gait imbalance (HP:0002141)2.02028292
108Anencephaly (HP:0002323)2.00882612
109Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00459206
110Recurrent bronchitis (HP:0002837)2.00163550
111Supranuclear gaze palsy (HP:0000605)1.99422967
112Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99140150
113Progressive inability to walk (HP:0002505)1.98901707
114Neuronal loss in central nervous system (HP:0002529)1.98818517
115Bile duct proliferation (HP:0001408)1.98597976
116Abnormal biliary tract physiology (HP:0012439)1.98597976
117Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98392055
118Widely spaced teeth (HP:0000687)1.97336188
119Abnormal social behavior (HP:0012433)1.95879026
120Impaired social interactions (HP:0000735)1.95879026
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.95584393
122Breast hypoplasia (HP:0003187)1.95400205
123T lymphocytopenia (HP:0005403)1.94960322
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94093278
125Stereotypic behavior (HP:0000733)1.92122636
126Depression (HP:0000716)1.89410279
127Congenital primary aphakia (HP:0007707)1.89371374
128Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89062402
129Abnormality of the pons (HP:0007361)1.88790534
130Pancreatic fibrosis (HP:0100732)1.88710438
131Male pseudohermaphroditism (HP:0000037)1.88559853
132Bony spicule pigmentary retinopathy (HP:0007737)1.87933444
133Abnormality of the anterior horn cell (HP:0006802)1.86909074
134Degeneration of anterior horn cells (HP:0002398)1.86909074
135Truncal ataxia (HP:0002078)1.85761494
136Parakeratosis (HP:0001036)1.84918224
137Increased neuronal autofluorescent lipopigment (HP:0002074)1.84542522
138Congenital sensorineural hearing impairment (HP:0008527)1.84384568
139Severe muscular hypotonia (HP:0006829)1.83642716
140Hemiparesis (HP:0001269)1.79747367
141Birth length less than 3rd percentile (HP:0003561)1.79627370
142Hypoplasia of the pons (HP:0012110)1.79197284
143Scanning speech (HP:0002168)1.79080359
144Renal cortical cysts (HP:0000803)1.78649977
145Hypoplastic ischia (HP:0003175)1.78367296
146Abnormality of T cell number (HP:0011839)1.77935656
147Abnormality of the vasculature of the conjunctiva (HP:0008054)1.77690218
148Increased number of teeth (HP:0011069)1.77492609
149Distal lower limb amyotrophy (HP:0008944)1.77427894
150Diminished motivation (HP:0000745)1.77324227
151Mediastinal lymphadenopathy (HP:0100721)1.76569646
1522-3 toe syndactyly (HP:0004691)1.75990120
153Fatigue (HP:0012378)1.75681983
154Abnormality of saccadic eye movements (HP:0000570)1.75176232
155Specific learning disability (HP:0001328)1.73983828
156Atonic seizures (HP:0010819)1.73561055
157Postaxial foot polydactyly (HP:0001830)1.72647597
158Increased cerebral lipofuscin (HP:0011813)1.72631898
159Nephrogenic diabetes insipidus (HP:0009806)1.72319235
160Abnormal respiratory motile cilium physiology (HP:0012261)1.72046372
161Elevated erythrocyte sedimentation rate (HP:0003565)1.72030635
162Volvulus (HP:0002580)1.70737886
163True hermaphroditism (HP:0010459)1.70312993
164Hemiplegia (HP:0002301)1.70184768
165Abnormality of binocular vision (HP:0011514)1.69326971
166Diplopia (HP:0000651)1.69326971
167Annular pancreas (HP:0001734)1.68641322
168Narrow nasal bridge (HP:0000446)1.67680084
169Abnormality of renin-angiotensin system (HP:0000847)1.67393620
170Poor coordination (HP:0002370)1.67179771
171Bulbous nose (HP:0000414)1.65285083
172Excessive salivation (HP:0003781)1.63248023
173Drooling (HP:0002307)1.63248023
174Dyskinesia (HP:0100660)1.63032073
175Tachypnea (HP:0002789)1.62844848
176Recurrent viral infections (HP:0004429)1.62150439
177Hypoplasia of the thymus (HP:0000778)1.61158656
178Hypoplastic iliac wings (HP:0002866)1.60239746
179Hyperventilation (HP:0002883)1.59885814
180Neurofibrillary tangles (HP:0002185)1.59423891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.50002464
2CDC75.57378722
3ACVR1B4.19767649
4BMPR1B3.67262835
5ADRBK23.18812690
6MAP3K132.80514902
7CCNB12.74119439
8INSRR2.61571332
9MAPKAPK52.58986766
10WNK42.47522688
11EEF2K2.27798630
12ZAK2.16787078
13DAPK22.15795082
14GRK12.12105482
15MAP3K92.01234236
16TLK12.00513132
17CDK81.94415968
18EPHB11.86195086
19FES1.80143443
20CSF1R1.80038868
21CLK11.78647125
22BRSK21.75347534
23WNK31.71577115
24PINK11.69448347
25ARAF1.69273056
26PNCK1.65968271
27EPHA41.64523817
28NEK61.64403957
29CAMKK21.62498181
30MAPK131.61437422
31MAPK151.58044801
32ADRBK11.56867496
33TXK1.53779582
34TGFBR11.52136912
35FGR1.48874398
36KIT1.45384572
37PRKCH1.43020087
38NUAK11.41106457
39TAOK31.40670725
40MAP2K71.38771251
41MAP3K41.38264032
42NTRK21.35205327
43PIK3CA1.33595433
44MAP4K11.32501798
45PKN11.30222106
46MELK1.28163395
47SGK4941.26698512
48SGK2231.26698512
49WNK11.24642238
50MAP4K21.21984274
51RIPK41.19841082
52CAMK1G1.19569801
53CAMK1D1.16464742
54FGFR21.15394265
55CAMKK11.12536940
56BRSK11.10610599
57PDK11.09601600
58NTRK31.09241525
59ALK1.07926823
60NEK21.07037885
61MINK11.05816545
62PRKD21.05078184
63PTK2B1.04395745
64STK391.03912116
65EPHA31.02188587
66MUSK1.01826727
67SGK20.97537526
68CDK190.97180297
69TRPM70.95423360
70RET0.93247030
71TNIK0.91903035
72OXSR10.91705061
73MARK10.91147471
74RAF10.91038376
75PAK30.89640166
76UHMK10.85986240
77MKNK10.83929468
78MAP2K60.83664161
79PRKCG0.83619330
80MAP3K140.83335154
81CDK50.82354612
82MAP3K60.80349378
83SRPK10.79290483
84STK110.78976932
85VRK10.77797774
86PDPK10.77552721
87SIK20.77043213
88DMPK0.76374052
89CAMK10.76017528
90PRKCQ0.75867738
91PRKD30.74993865
92SYK0.73530053
93IRAK10.71806604
94KSR20.71500495
95TSSK60.70489334
96MAPKAPK30.70236538
97CASK0.67380924
98ITK0.65794554
99CAMK40.65448396
100PRPF4B0.64250689
101CDK120.63580953
102SGK30.63344086
103IRAK40.63308176
104RPS6KB10.62338327
105MAP3K120.61378128
106HIPK20.61342038
107OBSCN0.61246050
108TNK20.60476756
109ATR0.60354367
110SGK10.59796935
111MAP2K10.59239268
112WEE10.58084191
113DAPK10.58060926
114IKBKB0.57283220
115PRKCE0.57246353
116CAMK2A0.56103662
117MAP3K70.54334122
118TYRO30.53662066
119NLK0.53567701
120HCK0.53403857
121CHUK0.52513326
122AKT30.52169518
123PRKAA20.51898159
124TIE10.51071923
125MKNK20.49164744
126IKBKE0.48779857
127ERBB20.48698935
128BMPR20.48095984
129PIK3CG0.47588878
130DYRK20.47383875
131STK38L0.45321181
132MAPK110.44948395
133PLK20.44412455
134TEC0.44395029
135MAP2K20.42144610
136GRK60.41543460
137PRKAA10.41452732
138BLK0.41113679
139PHKG10.40291992
140PHKG20.40291992
141PRKCZ0.40241741
142FGFR30.39829978
143MAP2K40.39033959
144MARK30.38403728
145PRKACA0.38230648
146BTK0.37576665
147PLK30.37095908
148LCK0.36791790
149MATK0.35255573
150MAP3K20.34960273
151RPS6KA30.34868298
152DYRK1A0.34792579
153BRD40.34274268
154CSNK1G20.34053472
155GRK50.33577726
156PDGFRB0.33172970
157PRKACB0.32751170
158CSNK1D0.32731334
159CDK20.32480819
160MAP3K10.32422716
161MAPK80.30830776

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.87713441
2Linoleic acid metabolism_Homo sapiens_hsa005912.76141689
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.70105230
4Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.28354272
5Olfactory transduction_Homo sapiens_hsa047402.18873779
6Morphine addiction_Homo sapiens_hsa050322.16272955
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15156592
8Glutamatergic synapse_Homo sapiens_hsa047242.07493273
9Butanoate metabolism_Homo sapiens_hsa006501.90055825
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88404294
11Selenocompound metabolism_Homo sapiens_hsa004501.85909831
12* Circadian entrainment_Homo sapiens_hsa047131.85810250
13GABAergic synapse_Homo sapiens_hsa047271.72175398
14ABC transporters_Homo sapiens_hsa020101.71310700
15Long-term potentiation_Homo sapiens_hsa047201.71001049
16DNA replication_Homo sapiens_hsa030301.68359781
17Tryptophan metabolism_Homo sapiens_hsa003801.66636295
18Nicotine addiction_Homo sapiens_hsa050331.64299234
19Homologous recombination_Homo sapiens_hsa034401.61242590
20Long-term depression_Homo sapiens_hsa047301.56677050
21Cholinergic synapse_Homo sapiens_hsa047251.54184270
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53186641
23B cell receptor signaling pathway_Homo sapiens_hsa046621.51624358
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.50812959
25Dopaminergic synapse_Homo sapiens_hsa047281.46801417
26Caffeine metabolism_Homo sapiens_hsa002321.41236676
27Renin secretion_Homo sapiens_hsa049241.40737650
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39730121
29Dorso-ventral axis formation_Homo sapiens_hsa043201.37157092
30Salivary secretion_Homo sapiens_hsa049701.36418811
31Chemokine signaling pathway_Homo sapiens_hsa040621.30457074
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30192526
33Serotonergic synapse_Homo sapiens_hsa047261.29816773
34Amphetamine addiction_Homo sapiens_hsa050311.29445169
35Non-homologous end-joining_Homo sapiens_hsa034501.29349390
36Oocyte meiosis_Homo sapiens_hsa041141.27436866
37Gastric acid secretion_Homo sapiens_hsa049711.24828518
38Ovarian steroidogenesis_Homo sapiens_hsa049131.23852576
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23737545
40Mismatch repair_Homo sapiens_hsa034301.20667625
41African trypanosomiasis_Homo sapiens_hsa051431.18610421
42Oxytocin signaling pathway_Homo sapiens_hsa049211.17606989
43Cocaine addiction_Homo sapiens_hsa050301.17038732
44Fanconi anemia pathway_Homo sapiens_hsa034601.15924325
45Histidine metabolism_Homo sapiens_hsa003401.15319532
46Cell cycle_Homo sapiens_hsa041101.14222440
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11325825
48Sphingolipid signaling pathway_Homo sapiens_hsa040711.11023221
49Platelet activation_Homo sapiens_hsa046111.10389430
50Inositol phosphate metabolism_Homo sapiens_hsa005621.08803420
51* MAPK signaling pathway_Homo sapiens_hsa040101.07502935
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07458837
53RNA degradation_Homo sapiens_hsa030181.03523715
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02226960
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02192439
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.01141835
57Shigellosis_Homo sapiens_hsa051310.99840721
58Non-small cell lung cancer_Homo sapiens_hsa052230.99028843
59Arachidonic acid metabolism_Homo sapiens_hsa005900.98830809
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98316153
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98066043
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96898092
63* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96728542
64Base excision repair_Homo sapiens_hsa034100.94631845
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92253878
66cAMP signaling pathway_Homo sapiens_hsa040240.92149945
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.91248534
68Chemical carcinogenesis_Homo sapiens_hsa052040.90702720
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90420008
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90217694
71Vitamin B6 metabolism_Homo sapiens_hsa007500.89222008
72Calcium signaling pathway_Homo sapiens_hsa040200.88228068
73Synaptic vesicle cycle_Homo sapiens_hsa047210.87736654
74Ether lipid metabolism_Homo sapiens_hsa005650.87130824
75Glycerolipid metabolism_Homo sapiens_hsa005610.86537880
76Alcoholism_Homo sapiens_hsa050340.86112779
77Hepatitis B_Homo sapiens_hsa051610.85376910
78GnRH signaling pathway_Homo sapiens_hsa049120.84529561
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83778514
80mRNA surveillance pathway_Homo sapiens_hsa030150.82666924
81Gap junction_Homo sapiens_hsa045400.82467351
82Graft-versus-host disease_Homo sapiens_hsa053320.82462608
83Asthma_Homo sapiens_hsa053100.82217606
84T cell receptor signaling pathway_Homo sapiens_hsa046600.81516939
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80456763
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80048854
87Chronic myeloid leukemia_Homo sapiens_hsa052200.79791264
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79472511
89Leishmaniasis_Homo sapiens_hsa051400.79326348
90Osteoclast differentiation_Homo sapiens_hsa043800.78064158
91Salmonella infection_Homo sapiens_hsa051320.78002009
92Herpes simplex infection_Homo sapiens_hsa051680.77675667
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.77623892
94Primary immunodeficiency_Homo sapiens_hsa053400.77381403
95Fatty acid biosynthesis_Homo sapiens_hsa000610.77205638
96* Neurotrophin signaling pathway_Homo sapiens_hsa047220.76791936
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76416128
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76145185
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75521717
100Taste transduction_Homo sapiens_hsa047420.74591222
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74422341
102Basal transcription factors_Homo sapiens_hsa030220.74389477
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74387133
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.73507482
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73412790
106ErbB signaling pathway_Homo sapiens_hsa040120.73140775
107Estrogen signaling pathway_Homo sapiens_hsa049150.70661433
108Cardiac muscle contraction_Homo sapiens_hsa042600.70432219
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68531743
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68504631
111Measles_Homo sapiens_hsa051620.68112853
112Axon guidance_Homo sapiens_hsa043600.67531838
113Insulin secretion_Homo sapiens_hsa049110.67210174
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66662628
115Nucleotide excision repair_Homo sapiens_hsa034200.66067303
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65913753
117Phototransduction_Homo sapiens_hsa047440.65444752
118Retinol metabolism_Homo sapiens_hsa008300.64632526
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63665046
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.63038477
121beta-Alanine metabolism_Homo sapiens_hsa004100.62689541
122Regulation of autophagy_Homo sapiens_hsa041400.62436035
123Endocytosis_Homo sapiens_hsa041440.62430244
124Peroxisome_Homo sapiens_hsa041460.62055516
125Toxoplasmosis_Homo sapiens_hsa051450.60475980
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59581906
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59452154
128Choline metabolism in cancer_Homo sapiens_hsa052310.58564275
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58160209
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.58083133
131Type II diabetes mellitus_Homo sapiens_hsa049300.57881837
132Ras signaling pathway_Homo sapiens_hsa040140.57338356
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57118365
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56930280
135VEGF signaling pathway_Homo sapiens_hsa043700.56780496
136Vitamin digestion and absorption_Homo sapiens_hsa049770.55847675
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55544497
138Mineral absorption_Homo sapiens_hsa049780.54962550
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54757416
140Hematopoietic cell lineage_Homo sapiens_hsa046400.53178596
141Circadian rhythm_Homo sapiens_hsa047100.52515164
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52094646
143Pancreatic cancer_Homo sapiens_hsa052120.51375365
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.51038534
145RNA polymerase_Homo sapiens_hsa030200.50787169
146Autoimmune thyroid disease_Homo sapiens_hsa053200.50775642
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49738532
148Allograft rejection_Homo sapiens_hsa053300.47557474
149Sulfur relay system_Homo sapiens_hsa041220.46351126
150Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45642050
151Oxidative phosphorylation_Homo sapiens_hsa001900.44343255
152Bile secretion_Homo sapiens_hsa049760.42651825
153One carbon pool by folate_Homo sapiens_hsa006700.41375238
154Pancreatic secretion_Homo sapiens_hsa049720.41189015
155Type I diabetes mellitus_Homo sapiens_hsa049400.38222331
156Propanoate metabolism_Homo sapiens_hsa006400.34349116
157Fat digestion and absorption_Homo sapiens_hsa049750.32419130

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