RPS6KA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.72528051
2regulation of DNA endoreduplication (GO:0032875)5.40304715
3pre-miRNA processing (GO:0031054)5.04860050
4membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.94339687
5nuclear pore organization (GO:0006999)4.79852191
6DNA unwinding involved in DNA replication (GO:0006268)4.71248975
7regulation of gene silencing by miRNA (GO:0060964)4.66611886
8regulation of gene silencing by RNA (GO:0060966)4.66611886
9regulation of posttranscriptional gene silencing (GO:0060147)4.66611886
10parturition (GO:0007567)4.66273910
11nuclear pore complex assembly (GO:0051292)4.64605666
12behavioral response to nicotine (GO:0035095)4.61814735
13paraxial mesoderm development (GO:0048339)4.59253072
14membrane repolarization during action potential (GO:0086011)4.51210566
15regulation of sister chromatid cohesion (GO:0007063)4.20099822
16DNA replication-dependent nucleosome organization (GO:0034723)4.14572013
17DNA replication-dependent nucleosome assembly (GO:0006335)4.14572013
18sulfation (GO:0051923)4.11778353
19protein localization to kinetochore (GO:0034501)4.06529079
20magnesium ion transport (GO:0015693)4.04043208
21mitotic metaphase plate congression (GO:0007080)3.97450203
22regulation of glomerulus development (GO:0090192)3.93575121
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.87001253
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.87001253
25NADH dehydrogenase complex assembly (GO:0010257)3.87001253
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.79018768
27mitotic chromosome condensation (GO:0007076)3.71002417
28water-soluble vitamin biosynthetic process (GO:0042364)3.70154364
29regulation of skeletal muscle contraction (GO:0014819)3.64230149
30mitotic nuclear envelope disassembly (GO:0007077)3.62887236
31metaphase plate congression (GO:0051310)3.59652449
32mitotic sister chromatid cohesion (GO:0007064)3.59469374
33positive regulation of synapse maturation (GO:0090129)3.58454878
34kinetochore organization (GO:0051383)3.57947048
35DNA replication initiation (GO:0006270)3.55769431
36sister chromatid segregation (GO:0000819)3.52907860
37mitotic sister chromatid segregation (GO:0000070)3.50270853
38membrane disassembly (GO:0030397)3.47839567
39nuclear envelope disassembly (GO:0051081)3.47839567
40somite development (GO:0061053)3.47278500
41regulation of membrane repolarization (GO:0060306)3.44450240
42regulation of helicase activity (GO:0051095)3.43607438
43protein complex biogenesis (GO:0070271)3.43258585
44protein localization to chromosome, centromeric region (GO:0071459)3.42243253
45chromatin remodeling at centromere (GO:0031055)3.40942656
46heterochromatin organization (GO:0070828)3.38858691
47piRNA metabolic process (GO:0034587)3.37406251
48cell proliferation in forebrain (GO:0021846)3.37104821
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36471297
50regulation of histone H3-K9 methylation (GO:0051570)3.36098455
51positive regulation of potassium ion transmembrane transport (GO:1901381)3.35384277
52negative regulation of histone methylation (GO:0031061)3.33943731
53pore complex assembly (GO:0046931)3.33865901
54protein polyglutamylation (GO:0018095)3.32366755
55negative regulation of chromosome segregation (GO:0051985)3.30773532
56folic acid-containing compound biosynthetic process (GO:0009396)3.30269339
57spindle checkpoint (GO:0031577)3.29782968
58regulation of chromosome segregation (GO:0051983)3.29014790
59mitotic spindle checkpoint (GO:0071174)3.28882199
60CENP-A containing nucleosome assembly (GO:0034080)3.27670311
61nucleobase biosynthetic process (GO:0046112)3.27230692
62histone H2A monoubiquitination (GO:0035518)3.25294362
63negative regulation of mitotic sister chromatid separation (GO:2000816)3.25227443
64negative regulation of mitotic sister chromatid segregation (GO:0033048)3.25227443
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.25227443
66negative regulation of sister chromatid segregation (GO:0033046)3.25227443
67DNA replication-independent nucleosome organization (GO:0034724)3.24797035
68DNA replication-independent nucleosome assembly (GO:0006336)3.24797035
69regulation of centriole replication (GO:0046599)3.22406310
70peptidyl-arginine omega-N-methylation (GO:0035247)3.21810031
71spindle assembly checkpoint (GO:0071173)3.21120430
72regulation of centrosome cycle (GO:0046605)3.21051096
73ribosome assembly (GO:0042255)3.20215214
74membrane repolarization (GO:0086009)3.19224473
75mitotic spindle assembly checkpoint (GO:0007094)3.18887325
76mitochondrial respiratory chain complex assembly (GO:0033108)3.18654379
77histone exchange (GO:0043486)3.18009386
78negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17790192
79regulation of cell proliferation involved in kidney development (GO:1901722)3.16648348
80kinetochore assembly (GO:0051382)3.16432003
81regulation of telomere maintenance via telomerase (GO:0032210)3.16296375
82DNA methylation involved in gamete generation (GO:0043046)3.16017842
83histone arginine methylation (GO:0034969)3.15612050
84DNA duplex unwinding (GO:0032508)3.15362546
85cellular response to electrical stimulus (GO:0071257)3.14955260
86DNA geometric change (GO:0032392)3.14675345
87regulation of synapse maturation (GO:0090128)3.14452191
88regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13627029
89serotonin metabolic process (GO:0042428)3.11783832
90negative regulation of DNA repair (GO:0045738)3.11696437
91fat-soluble vitamin catabolic process (GO:0042363)3.10484727
92vitamin catabolic process (GO:0009111)3.10484727
93DNA deamination (GO:0045006)3.09090391
94negative regulation of DNA-dependent DNA replication (GO:2000104)3.08267455
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08143708
96maturation of SSU-rRNA (GO:0030490)3.08137507
97positive regulation of chromosome segregation (GO:0051984)3.07958197
98regulation of sister chromatid segregation (GO:0033045)3.07749182
99regulation of mitotic sister chromatid separation (GO:0010965)3.07749182
100regulation of mitotic sister chromatid segregation (GO:0033047)3.07749182
101cellular potassium ion homeostasis (GO:0030007)3.07692143
102chromatin assembly (GO:0031497)3.04177910
103DNA strand elongation involved in DNA replication (GO:0006271)3.03178992
104chromatin assembly or disassembly (GO:0006333)3.03079972
105establishment of chromosome localization (GO:0051303)3.02983249
106peptidyl-arginine N-methylation (GO:0035246)3.02405824
107peptidyl-arginine methylation (GO:0018216)3.02405824
108attachment of spindle microtubules to kinetochore (GO:0008608)3.01979428
109somatic hypermutation of immunoglobulin genes (GO:0016446)3.01531888
110somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01531888
111positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00969254
112positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00969254
113positive regulation of mitotic sister chromatid separation (GO:1901970)3.00969254
114purine nucleobase biosynthetic process (GO:0009113)2.99505990
115endoderm formation (GO:0001706)2.99354645
116pharyngeal system development (GO:0060037)2.99224183
117establishment of integrated proviral latency (GO:0075713)2.99023808
118regulation of spindle organization (GO:0090224)2.98319585
119IMP biosynthetic process (GO:0006188)2.96162682
120protein localization to chromosome (GO:0034502)2.94697059
121positive regulation of meiosis (GO:0045836)2.94667151
122regulation of RNA export from nucleus (GO:0046831)2.93458090
123notochord development (GO:0030903)2.92554391
124signal transduction involved in regulation of gene expression (GO:0023019)2.91987782
125DNA replication checkpoint (GO:0000076)2.91431431
126interkinetic nuclear migration (GO:0022027)2.91156273
127primary amino compound metabolic process (GO:1901160)2.90621647
128negative regulation of systemic arterial blood pressure (GO:0003085)2.88817333
129potassium ion import (GO:0010107)2.88231069
130ncRNA catabolic process (GO:0034661)2.87294117
131ovulation cycle (GO:0042698)2.86945584
132formation of translation preinitiation complex (GO:0001731)2.86042844
133ATP-dependent chromatin remodeling (GO:0043044)2.85925416
134DNA strand elongation (GO:0022616)2.85443243
135indolalkylamine metabolic process (GO:0006586)2.84559360
136membrane depolarization during action potential (GO:0086010)2.83233061
137microtubule depolymerization (GO:0007019)2.82012741
138detection of light stimulus involved in visual perception (GO:0050908)2.80976135
139detection of light stimulus involved in sensory perception (GO:0050962)2.80976135
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79794656
141dosage compensation (GO:0007549)2.79650777
142establishment of apical/basal cell polarity (GO:0035089)2.79393657
143regulation of potassium ion transmembrane transport (GO:1901379)2.78755382
144regulation of gene silencing (GO:0060968)2.77139830
145regulation of centrosome duplication (GO:0010824)2.76337976
146protein K6-linked ubiquitination (GO:0085020)2.75702059
147positive regulation of meiotic cell cycle (GO:0051446)2.74539321
148positive regulation of SMAD protein import into nucleus (GO:0060391)2.74351128
149gamma-aminobutyric acid transport (GO:0015812)2.73347486
150chromosome segregation (GO:0007059)2.72097775
151otic vesicle formation (GO:0030916)2.70325081
152negative regulation of appetite (GO:0032099)2.69094017
153negative regulation of response to food (GO:0032096)2.69094017
154positive regulation of cardiac muscle cell differentiation (GO:2000727)2.68747308
155cardiovascular system development (GO:0072358)2.67072792
156regulation of heart rate by cardiac conduction (GO:0086091)2.66475591
157regulation of meiosis I (GO:0060631)2.65586285
158fucose catabolic process (GO:0019317)2.65427266
159L-fucose metabolic process (GO:0042354)2.65427266
160L-fucose catabolic process (GO:0042355)2.65427266
161negative regulation of transcription regulatory region DNA binding (GO:2000678)2.65314382
162regulation of germinal center formation (GO:0002634)2.63787802
163positive regulation of male gonad development (GO:2000020)2.63048637
164oxidative demethylation (GO:0070989)2.62816843
165regulation of male gonad development (GO:2000018)2.61155209
166flavonoid metabolic process (GO:0009812)2.58975633
167negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58519877
168retinal ganglion cell axon guidance (GO:0031290)2.56455966
169indole-containing compound metabolic process (GO:0042430)2.56116227
170tryptophan catabolic process (GO:0006569)2.55808445
171indole-containing compound catabolic process (GO:0042436)2.55808445
172indolalkylamine catabolic process (GO:0046218)2.55808445
173nonmotile primary cilium assembly (GO:0035058)2.55485431
174kynurenine metabolic process (GO:0070189)2.55388553
175response to electrical stimulus (GO:0051602)2.54407831
176vitamin A metabolic process (GO:0006776)2.54054323
177transmission of nerve impulse (GO:0019226)2.53501378
178regulation of female receptivity (GO:0045924)2.52397606
179action potential (GO:0001508)2.52004525
180metanephric mesenchyme development (GO:0072075)2.49303672
181limb bud formation (GO:0060174)2.47898335
182axoneme assembly (GO:0035082)2.47125073
183multicellular organismal signaling (GO:0035637)2.46541711
184dorsal/ventral axis specification (GO:0009950)2.46250586
185cellular anion homeostasis (GO:0030002)2.46006115
186G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44442869
187prostate gland growth (GO:0060736)2.44266800
188mesonephros development (GO:0001823)2.42891153
189synapsis (GO:0007129)2.42456141
190mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41969607
191negative regulation of astrocyte differentiation (GO:0048712)2.41609463
192artery development (GO:0060840)2.41472282
193regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40923648
194neuronal action potential (GO:0019228)2.39340129
195positive regulation of cAMP-mediated signaling (GO:0043950)2.38748284
196dentate gyrus development (GO:0021542)2.38358445
197regulation of hippo signaling (GO:0035330)2.37557937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.07965574
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.98542540
3EZH2_22144423_ChIP-Seq_EOC_Human4.22561592
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.17451521
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.03655687
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.37326328
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.30743977
8GBX2_23144817_ChIP-Seq_PC3_Human3.06186512
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05016464
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.00579771
11VDR_22108803_ChIP-Seq_LS180_Human2.93337382
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80689613
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73142660
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.66443292
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63855513
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58408367
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.53046645
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35115538
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35115538
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35115538
21ZNF274_21170338_ChIP-Seq_K562_Hela2.34951047
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33953932
23AR_21909140_ChIP-Seq_LNCAP_Human2.32074159
24IGF1R_20145208_ChIP-Seq_DFB_Human2.27981295
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23692307
26SOX2_18555785_ChIP-Seq_MESCs_Mouse2.23669749
27TAF15_26573619_Chip-Seq_HEK293_Human2.23044553
28BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21821311
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.21159437
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20667873
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19545526
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18557494
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18028428
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14957653
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.13691862
36XRN2_22483619_ChIP-Seq_HELA_Human2.04660028
37E2F1_21310950_ChIP-Seq_MCF-7_Human2.03974395
38MYC_18358816_ChIP-ChIP_MESCs_Mouse2.03103651
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97871740
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.95860381
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.95573129
42P300_19829295_ChIP-Seq_ESCs_Human1.95535039
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94313305
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.92014497
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.90440203
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90409255
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88070101
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84547971
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83615762
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83606661
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.83067354
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.82611014
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.81269212
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.77330114
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76108342
56* RNF2_27304074_Chip-Seq_NSC_Mouse1.75665959
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75480523
58TCF3_18692474_ChIP-Seq_MESCs_Mouse1.74856079
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.73322314
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73107003
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.71405624
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71273632
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70119772
64TTF2_22483619_ChIP-Seq_HELA_Human1.70000043
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68523933
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.66559217
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.66257726
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64353827
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63728989
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63403044
71IRF1_19129219_ChIP-ChIP_H3396_Human1.62646440
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.61313479
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.61301569
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60960450
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.60847823
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60438575
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59661494
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57024326
79ER_23166858_ChIP-Seq_MCF-7_Human1.56881719
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.56455133
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55042994
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54847736
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53287122
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51255212
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51059131
86SMAD4_21799915_ChIP-Seq_A2780_Human1.49994968
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47526942
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.46761071
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46477030
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46282869
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45884432
92AR_25329375_ChIP-Seq_VCAP_Human1.45112478
93STAT3_23295773_ChIP-Seq_U87_Human1.44593219
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44482790
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44001762
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41906896
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41813437
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41436967
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40150369
100SOX2_16153702_ChIP-ChIP_HESCs_Human1.39922730
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39311192
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38896358
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38848591
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.38751588
105TCF4_23295773_ChIP-Seq_U87_Human1.37998368
106REST_21632747_ChIP-Seq_MESCs_Mouse1.37501412
107BCAT_22108803_ChIP-Seq_LS180_Human1.36220549
108JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34640864
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34597797
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33907407
111CBP_20019798_ChIP-Seq_JUKART_Human1.33907407
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.32849587
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32560496
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31221564
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30187406
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29270898
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28537152
118SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26902740
119NANOG_16153702_ChIP-ChIP_HESCs_Human1.26612699
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25557766
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25454064
122VDR_23849224_ChIP-Seq_CD4+_Human1.24610031
123EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22603072
124RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22603072
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22305339
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.20783060
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20722775
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20568243
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20230216
130RNF2_27304074_Chip-Seq_ESCs_Mouse1.19262649
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17913355
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17913355
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17878622
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15540870
135EZH2_27294783_Chip-Seq_NPCs_Mouse1.14962809
136SMAD4_21741376_ChIP-Seq_EPCs_Human1.14585135
137ELK1_19687146_ChIP-ChIP_HELA_Human1.13914231
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.13897423
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13868504
140NANOG_18555785_Chip-Seq_ESCs_Mouse1.13808310
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13683287
142SOX2_19829295_ChIP-Seq_ESCs_Human1.13458241
143NANOG_19829295_ChIP-Seq_ESCs_Human1.13458241
144STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13405043
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.13192975
146KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13086315
147BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12511807
148GABP_19822575_ChIP-Seq_HepG2_Human1.12398280
149FOXP3_21729870_ChIP-Seq_TREG_Human1.11374945
150POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11246869
151JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11217301
152POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10965769
153SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10956570
154RUNX2_22187159_ChIP-Seq_PCA_Human1.10634612
155PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10549458
156MYC_18940864_ChIP-ChIP_HL60_Human1.10306118
157KDM5A_27292631_Chip-Seq_BREAST_Human1.09935685
158TCF4_22108803_ChIP-Seq_LS180_Human1.09904763
159JUN_21703547_ChIP-Seq_K562_Human1.09406843
160EZH2_27294783_Chip-Seq_ESCs_Mouse1.09374702
161DCP1A_22483619_ChIP-Seq_HELA_Human1.09327169
162FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08960624
163FOXA1_25329375_ChIP-Seq_VCAP_Human1.08960624
164NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08570345
165* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08259940
166TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08047155
167NFE2_27457419_Chip-Seq_LIVER_Mouse1.07420513
168ARNT_22903824_ChIP-Seq_MCF-7_Human1.05868917
169AR_21572438_ChIP-Seq_LNCaP_Human1.05552816
170EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05415909
171P53_22387025_ChIP-Seq_ESCs_Mouse1.05105764
172SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04496932
173TAL1_26923725_Chip-Seq_HPCs_Mouse1.04092711
174E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03657845
175AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02669221
176SOX2_21211035_ChIP-Seq_LN229_Gbm1.02653184
177CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02509525
178TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02419616
179TP53_22573176_ChIP-Seq_HFKS_Human1.01600372
180CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00939493
181* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96150708
182ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94124630
183FUS_26573619_Chip-Seq_HEK293_Human0.93674999
184HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92588173
185DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92137284
186EWS_26573619_Chip-Seq_HEK293_Human0.92029297
187PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91734830
188NANOG_18692474_ChIP-Seq_MESCs_Mouse0.89681250
189POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.88013099
190CHD1_26751641_Chip-Seq_LNCaP_Human0.87538135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.99997281
2MP0003121_genomic_imprinting3.24018783
3MP0003941_abnormal_skin_development3.13742941
4MP0010094_abnormal_chromosome_stability3.11298574
5MP0004957_abnormal_blastocyst_morpholog3.07127600
6MP0003693_abnormal_embryo_hatching3.01862199
7MP0005646_abnormal_pituitary_gland2.91366247
8MP0003111_abnormal_nucleus_morphology2.84366721
9MP0004885_abnormal_endolymph2.81888962
10MP0000569_abnormal_digit_pigmentation2.73310261
11MP0003077_abnormal_cell_cycle2.67961445
12MP0000537_abnormal_urethra_morphology2.67692887
13MP0008057_abnormal_DNA_replication2.64936085
14MP0003890_abnormal_embryonic-extraembry2.62865111
15MP0010030_abnormal_orbit_morphology2.59349624
16MP0003122_maternal_imprinting2.57160909
17MP0010234_abnormal_vibrissa_follicle2.52119062
18MP0001968_abnormal_touch/_nociception2.13214327
19MP0001485_abnormal_pinna_reflex2.10263356
20MP0000631_abnormal_neuroendocrine_gland2.09267489
21MP0005389_reproductive_system_phenotype2.08454491
22MP0002837_dystrophic_cardiac_calcinosis2.07668819
23MP0002876_abnormal_thyroid_physiology2.07511660
24MP0004145_abnormal_muscle_electrophysio2.06225162
25MP0003119_abnormal_digestive_system2.04908675
26MP0009053_abnormal_anal_canal2.03907440
27MP0003646_muscle_fatigue2.03010735
28MP0008932_abnormal_embryonic_tissue2.02542932
29MP0001730_embryonic_growth_arrest2.01775816
30* MP0002084_abnormal_developmental_patter1.98840724
31MP0008058_abnormal_DNA_repair1.95288083
32MP0002653_abnormal_ependyma_morphology1.95164988
33MP0003937_abnormal_limbs/digits/tail_de1.89726874
34MP0002272_abnormal_nervous_system1.89422991
35MP0002638_abnormal_pupillary_reflex1.88618046
36MP0001293_anophthalmia1.87946225
37MP0003195_calcinosis1.87744350
38MP0009745_abnormal_behavioral_response1.85360593
39MP0002085_abnormal_embryonic_tissue1.85334333
40MP0001440_abnormal_grooming_behavior1.83974396
41MP0004197_abnormal_fetal_growth/weight/1.82394824
42MP0008877_abnormal_DNA_methylation1.79912879
43MP0005380_embryogenesis_phenotype1.77744925
44MP0001672_abnormal_embryogenesis/_devel1.77744925
45MP0002736_abnormal_nociception_after1.77153064
46MP0005551_abnormal_eye_electrophysiolog1.77054215
47MP0000350_abnormal_cell_proliferation1.74555069
48MP0002138_abnormal_hepatobiliary_system1.73519399
49MP0001697_abnormal_embryo_size1.69607329
50MP0003567_abnormal_fetal_cardiomyocyte1.68553974
51MP0004133_heterotaxia1.66966849
52MP0008007_abnormal_cellular_replicative1.64721776
53MP0009046_muscle_twitch1.61181100
54MP0010352_gastrointestinal_tract_polyps1.60074796
55MP0003315_abnormal_perineum_morphology1.60055712
56MP0002735_abnormal_chemical_nociception1.57461960
57MP0001486_abnormal_startle_reflex1.52650993
58MP0005076_abnormal_cell_differentiation1.52096505
59MP0002088_abnormal_embryonic_growth/wei1.51782398
60MP0003984_embryonic_growth_retardation1.51494789
61MP0004142_abnormal_muscle_tone1.46212290
62MP0001919_abnormal_reproductive_system1.45064639
63MP0002796_impaired_skin_barrier1.45039967
64* MP0002086_abnormal_extraembryonic_tissu1.43460628
65MP0002102_abnormal_ear_morphology1.43368861
66MP0003283_abnormal_digestive_organ1.41464966
67MP0003879_abnormal_hair_cell1.40558513
68MP0003385_abnormal_body_wall1.39491156
69MP0009672_abnormal_birth_weight1.37316938
70MP0008872_abnormal_physiological_respon1.36289740
71MP0002938_white_spotting1.35966516
72MP0003861_abnormal_nervous_system1.33457245
73MP0002064_seizures1.32828880
74MP0003880_abnormal_central_pattern1.31668702
75MP0000566_synostosis1.30531342
76MP0004215_abnormal_myocardial_fiber1.30240759
77MP0002080_prenatal_lethality1.29851632
78MP0006292_abnormal_olfactory_placode1.26568559
79MP0005253_abnormal_eye_physiology1.26285568
80MP0003635_abnormal_synaptic_transmissio1.25133215
81MP0003755_abnormal_palate_morphology1.24704763
82MP0004264_abnormal_extraembryonic_tissu1.23999420
83MP0010386_abnormal_urinary_bladder1.22989461
84MP0009703_decreased_birth_body1.22960096
85MP0010307_abnormal_tumor_latency1.22791135
86MP0003787_abnormal_imprinting1.21043590
87MP0002572_abnormal_emotion/affect_behav1.20589460
88MP0005423_abnormal_somatic_nervous1.20165352
89MP0002111_abnormal_tail_morphology1.19772937
90MP0002697_abnormal_eye_size1.19233107
91MP0001286_abnormal_eye_development1.18987444
92MP0002249_abnormal_larynx_morphology1.18004096
93MP0003942_abnormal_urinary_system1.17687214
94MP0005248_abnormal_Harderian_gland1.17289986
95MP0003935_abnormal_craniofacial_develop1.16436345
96MP0003705_abnormal_hypodermis_morpholog1.16114420
97MP0005187_abnormal_penis_morphology1.15873877
98MP0009780_abnormal_chondrocyte_physiolo1.15670370
99MP0006276_abnormal_autonomic_nervous1.13808970
100MP0008789_abnormal_olfactory_epithelium1.13372712
101MP0004019_abnormal_vitamin_homeostasis1.12654193
102MP0004043_abnormal_pH_regulation1.12620696
103MP0001188_hyperpigmentation1.12444333
104MP0004130_abnormal_muscle_cell1.10799057
105MP0004134_abnormal_chest_morphology1.10672745
106MP0010678_abnormal_skin_adnexa1.10489657
107MP0002063_abnormal_learning/memory/cond1.10307509
108MP0002733_abnormal_thermal_nociception1.10273924
109MP0005174_abnormal_tail_pigmentation1.09438178
110MP0001501_abnormal_sleep_pattern1.09186072
111MP0000516_abnormal_urinary_system1.09107536
112MP0005367_renal/urinary_system_phenotyp1.09107536
113MP0003115_abnormal_respiratory_system1.08544638
114MP0005501_abnormal_skin_physiology1.08083015
115MP0003011_delayed_dark_adaptation1.08050585
116MP0004085_abnormal_heartbeat1.07615291
117* MP0000432_abnormal_head_morphology1.07263804
118MP0002092_abnormal_eye_morphology1.06769858
119MP0001986_abnormal_taste_sensitivity1.06523691
120MP0001963_abnormal_hearing_physiology1.05644332
121MP0000026_abnormal_inner_ear1.05312293
122MP0002734_abnormal_mechanical_nocicepti1.05139928
123MP0002184_abnormal_innervation1.04844356
124MP0008995_early_reproductive_senescence1.04740561
125MP0000049_abnormal_middle_ear1.04734483
126MP0002932_abnormal_joint_morphology1.04563639
127MP0002233_abnormal_nose_morphology1.04220195
128MP0002282_abnormal_trachea_morphology1.03771164
129MP0002557_abnormal_social/conspecific_i1.03570510
130MP0001849_ear_inflammation1.03502200
131MP0001970_abnormal_pain_threshold1.03331563
132MP0005645_abnormal_hypothalamus_physiol1.02927413
133MP0003938_abnormal_ear_development1.01214344
134MP0000428_abnormal_craniofacial_morphol1.00910219
135MP0002210_abnormal_sex_determination0.98352646
136MP0004742_abnormal_vestibular_system0.98133857
137MP0002116_abnormal_craniofacial_bone0.94000933
138MP0003718_maternal_effect0.93106840
139MP0009384_cardiac_valve_regurgitation0.92544457
140MP0005499_abnormal_olfactory_system0.92270211
141MP0005394_taste/olfaction_phenotype0.92270211
142MP0002752_abnormal_somatic_nervous0.91835761
143MP0001905_abnormal_dopamine_level0.91318515
144MP0004233_abnormal_muscle_weight0.89712638
145MP0005195_abnormal_posterior_eye0.89211389
146MP0001145_abnormal_male_reproductive0.87814326
147MP0002067_abnormal_sensory_capabilities0.87643920
148MP0000230_abnormal_systemic_arterial0.87119186
149MP0001764_abnormal_homeostasis0.86104045
150MP0001502_abnormal_circadian_rhythm0.85655126
151MP0002114_abnormal_axial_skeleton0.85115370
152MP0000778_abnormal_nervous_system0.84819005
153MP0006072_abnormal_retinal_apoptosis0.82355810
154MP0000534_abnormal_ureter_morphology0.81217485
155MP0002081_perinatal_lethality0.80867319
156MP0002234_abnormal_pharynx_morphology0.80663349
157MP0009250_abnormal_appendicular_skeleto0.80659952
158MP0005410_abnormal_fertilization0.80539957
159MP0003786_premature_aging0.80439607
160MP0005623_abnormal_meninges_morphology0.79571398
161MP0005386_behavior/neurological_phenoty0.79500357
162MP0004924_abnormal_behavior0.79500357
163MP0003136_yellow_coat_color0.79464646
164MP0000613_abnormal_salivary_gland0.79310492
165MP0003137_abnormal_impulse_conducting0.78685066
166MP0001765_abnormal_ion_homeostasis0.78411560
167MP0000653_abnormal_sex_gland0.77647702
168MP0001929_abnormal_gametogenesis0.76771800
169MP0000678_abnormal_parathyroid_gland0.75877185
170MP0003698_abnormal_male_reproductive0.75420372
171MP0000383_abnormal_hair_follicle0.74977692
172MP0001915_intracranial_hemorrhage0.74612051
173MP0002160_abnormal_reproductive_system0.73997600
174MP0000762_abnormal_tongue_morphology0.72693077
175MP0001340_abnormal_eyelid_morphology0.71760318

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.80578603
2Colon cancer (HP:0003003)3.75353238
3True hermaphroditism (HP:0010459)3.72111184
4Pancreatic cysts (HP:0001737)3.45621343
5Ependymoma (HP:0002888)3.43115041
6Medulloblastoma (HP:0002885)3.39243322
7Abolished electroretinogram (ERG) (HP:0000550)3.29526889
8Supernumerary spleens (HP:0009799)3.28476580
9Nephronophthisis (HP:0000090)3.21821911
10Abnormality of the proximal phalanges of the hand (HP:0009834)3.14911326
11Abnormality of midbrain morphology (HP:0002418)3.10910710
12Molar tooth sign on MRI (HP:0002419)3.10910710
13Pancreatic fibrosis (HP:0100732)3.10168261
14Osteomalacia (HP:0002749)2.86378621
15Absent radius (HP:0003974)2.83835645
16Abnormal number of incisors (HP:0011064)2.83431931
17Short hallux (HP:0010109)2.82717596
18Chronic hepatic failure (HP:0100626)2.82156955
19Short 4th metacarpal (HP:0010044)2.81566176
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.81566176
21Congenital stationary night blindness (HP:0007642)2.81371837
22Selective tooth agenesis (HP:0001592)2.78145438
23Aplasia/Hypoplasia of the tibia (HP:0005772)2.76117194
24Rhabdomyosarcoma (HP:0002859)2.75508192
25Decreased circulating renin level (HP:0003351)2.75281291
26Abnormal lung lobation (HP:0002101)2.73314318
27Abnormality of the renal medulla (HP:0100957)2.73119316
28Congenital, generalized hypertrichosis (HP:0004540)2.70740851
29Abnormality of the phalanges of the 2nd finger (HP:0009541)2.70144860
30Abnormality of the middle phalanges of the toes (HP:0010183)2.69161358
31Aplasia/Hypoplasia of the hallux (HP:0008362)2.68961767
32Aplasia involving forearm bones (HP:0009822)2.68824760
33Absent forearm bone (HP:0003953)2.68824760
34Abnormality of the renal cortex (HP:0011035)2.67989822
35Abnormality of the astrocytes (HP:0100707)2.67601658
36Astrocytoma (HP:0009592)2.67601658
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.65795115
38Genetic anticipation (HP:0003743)2.65687107
39Abnormality of the renal collecting system (HP:0004742)2.65276697
40Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.64810140
41Birth length less than 3rd percentile (HP:0003561)2.63456755
42Volvulus (HP:0002580)2.62671090
43Patellar aplasia (HP:0006443)2.61104960
44Male pseudohermaphroditism (HP:0000037)2.59916926
45Chromsome breakage (HP:0040012)2.58514209
46Increased nuchal translucency (HP:0010880)2.58214270
47Nephroblastoma (Wilms tumor) (HP:0002667)2.57825574
48Rib fusion (HP:0000902)2.56151337
49Morphological abnormality of the middle ear (HP:0008609)2.55042257
50Abnormality of the phalanges of the 5th finger (HP:0004213)2.54835249
51Short tibia (HP:0005736)2.54672376
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54508157
53Pendular nystagmus (HP:0012043)2.54153200
54Aplasia/Hypoplasia of the patella (HP:0006498)2.53946715
55Facial hemangioma (HP:0000329)2.52181964
56Abnormality of abdominal situs (HP:0011620)2.52146376
57Abdominal situs inversus (HP:0003363)2.52146376
58Progressive cerebellar ataxia (HP:0002073)2.52045379
59Renal duplication (HP:0000075)2.50851334
60Hypoplasia of the uterus (HP:0000013)2.50642194
61Fibular aplasia (HP:0002990)2.49520537
62Clumsiness (HP:0002312)2.48194773
63Methylmalonic acidemia (HP:0002912)2.47699432
64Embryonal renal neoplasm (HP:0011794)2.46987996
65Proximal placement of thumb (HP:0009623)2.45890757
66Reticulocytopenia (HP:0001896)2.45710232
67Meckel diverticulum (HP:0002245)2.42811123
68Small hand (HP:0200055)2.41349265
69High anterior hairline (HP:0009890)2.40914803
70Missing ribs (HP:0000921)2.40882958
71Deviation of the thumb (HP:0009603)2.38511459
72Neoplasm of the oral cavity (HP:0100649)2.37421441
73Neoplasm of striated muscle (HP:0009728)2.34595299
74Biliary tract neoplasm (HP:0100574)2.32712183
75Asplenia (HP:0001746)2.32558594
76Abnormality of the ileum (HP:0001549)2.31686526
77Breast hypoplasia (HP:0003187)2.31160947
78Preauricular pit (HP:0004467)2.30669712
79Periauricular skin pits (HP:0100277)2.30669712
80Impulsivity (HP:0100710)2.29738328
81Glioma (HP:0009733)2.28121041
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.27899082
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27899082
84Aplasia/hypoplasia of the uterus (HP:0008684)2.26982762
85Atresia of the external auditory canal (HP:0000413)2.26531592
86Shawl scrotum (HP:0000049)2.25584060
87Aplasia/hypoplasia of the humerus (HP:0006507)2.25524457
88Aplasia/Hypoplasia of the spleen (HP:0010451)2.24753841
89Short 1st metacarpal (HP:0010034)2.24208152
90Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.24208152
91Anomalous pulmonary venous return (HP:0010772)2.23755697
92Abnormality of the nasal septum (HP:0000419)2.23733669
93Furrowed tongue (HP:0000221)2.22337180
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.20835268
95Anophthalmia (HP:0000528)2.20379110
96Skull defect (HP:0001362)2.17772424
97Broad-based gait (HP:0002136)2.16465431
98Decreased electroretinogram (ERG) amplitude (HP:0000654)2.16245640
99Supernumerary bones of the axial skeleton (HP:0009144)2.15896777
100Supernumerary ribs (HP:0005815)2.14746034
101Abnormality of the 4th metacarpal (HP:0010012)2.13783924
102Gaze-evoked nystagmus (HP:0000640)2.12592470
103Hyperventilation (HP:0002883)2.11004178
104Bilateral microphthalmos (HP:0007633)2.10658613
105Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.10151560
106Medial flaring of the eyebrow (HP:0010747)2.09787105
107Ectopic kidney (HP:0000086)2.09282085
108Renal cortical cysts (HP:0000803)2.09130899
109Symphalangism affecting the phalanges of the hand (HP:0009773)2.08180522
110Stenosis of the external auditory canal (HP:0000402)2.07551262
111Small intestinal stenosis (HP:0012848)2.06820238
112Duodenal stenosis (HP:0100867)2.06820238
113Short humerus (HP:0005792)2.05920916
114Hyperalaninemia (HP:0003348)2.04795636
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04795636
116Abnormality of alanine metabolism (HP:0010916)2.04795636
117Conjunctival hamartoma (HP:0100780)2.04226726
118Abnormality of chromosome stability (HP:0003220)2.04117209
119Malignant gastrointestinal tract tumors (HP:0006749)2.01437106
120Gastrointestinal carcinoma (HP:0002672)2.01437106
121Goiter (HP:0000853)2.00379418
122Abnormality of the 1st metacarpal (HP:0010009)2.00342575
123Tubular atrophy (HP:0000092)1.98923439
124Esophageal atresia (HP:0002032)1.98708062
125Abnormality of the pulmonary veins (HP:0011718)1.98397186
126Keratoconus (HP:0000563)1.97412623
127Increased corneal curvature (HP:0100692)1.97412623
128Shoulder girdle muscle weakness (HP:0003547)1.96966136
129Absent thumb (HP:0009777)1.96599585
130Hypoplastic labia majora (HP:0000059)1.96529335
131Short femoral neck (HP:0100864)1.95854288
132Facial cleft (HP:0002006)1.95146472
133Bifid tongue (HP:0010297)1.94721201
134Oligodactyly (HP:0012165)1.93935561
135Pelvic girdle muscle weakness (HP:0003749)1.93219368
136Intestinal polyp (HP:0005266)1.91670159
137Aplasia/Hypoplasia of the fibula (HP:0006492)1.90708562
138Hypoplasia of the ulna (HP:0003022)1.90708289
139Cystic liver disease (HP:0006706)1.90336775
140Agnosia (HP:0010524)1.90052106
141Intestinal polyposis (HP:0200008)1.89390907
142Hepatoblastoma (HP:0002884)1.88348900
143Abnormality of the preputium (HP:0100587)1.87465267
144Metabolic alkalosis (HP:0200114)1.86874614
145Abnormality of the duodenum (HP:0002246)1.86857008
146Decreased central vision (HP:0007663)1.86102822
147Broad thumb (HP:0011304)1.83925347
148Hyperglycinemia (HP:0002154)1.83069467
149Abnormality of renal resorption (HP:0011038)1.83028631
150Sclerocornea (HP:0000647)1.83026491
151Genital tract atresia (HP:0001827)1.82754046
152Megalencephaly (HP:0001355)1.82639255
153Synostosis of carpal bones (HP:0005048)1.82395360
154Congenital sensorineural hearing impairment (HP:0008527)1.82393821
155Chorioretinal atrophy (HP:0000533)1.82207803
156Ovarian neoplasm (HP:0100615)1.81782130
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80387970
158Febrile seizures (HP:0002373)1.79091783
159Diastasis recti (HP:0001540)1.79044020
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.78814685
161Absent/shortened dynein arms (HP:0200106)1.78814685
162Abnormality of DNA repair (HP:0003254)1.78644196
163Abnormal rod and cone electroretinograms (HP:0008323)1.77721928
164Vaginal atresia (HP:0000148)1.77456422
165Bony spicule pigmentary retinopathy (HP:0007737)1.77162881
166Short phalanx of the thumb (HP:0009660)1.76966468
1673-Methylglutaconic aciduria (HP:0003535)1.76125408
168Abnormality of cochlea (HP:0000375)1.76053212
169Abnormality of the labia majora (HP:0012881)1.76013443
170Bicornuate uterus (HP:0000813)1.73717962
171Neoplasm of the colon (HP:0100273)1.73454052
172Aplasia/Hypoplasia of the ulna (HP:0006495)1.73297560
173Neoplasm of the pancreas (HP:0002894)1.73284946
174Triphalangeal thumb (HP:0001199)1.73011235
175Oligodontia (HP:0000677)1.72353432
176Septo-optic dysplasia (HP:0100842)1.72016086
177Methylmalonic aciduria (HP:0012120)1.71942654
178Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.71862687
179Horseshoe kidney (HP:0000085)1.71809914
180Rectovaginal fistula (HP:0000143)1.71802874
181Rectal fistula (HP:0100590)1.71802874
182Adactyly (HP:0009776)1.70970187
183Abnormal drinking behavior (HP:0030082)1.70521141
184Papillary thyroid carcinoma (HP:0002895)1.70032238
185Hemivertebrae (HP:0002937)1.68890068
186Uterine neoplasm (HP:0010784)1.67712076
187Preauricular skin tag (HP:0000384)1.67364981
188Skin tags (HP:0010609)1.64820541
189Short thumb (HP:0009778)1.64529487
190Midline defect of the nose (HP:0004122)1.64370362
191Anal stenosis (HP:0002025)1.63334513
192Oral leukoplakia (HP:0002745)1.62565084
193Cutaneous finger syndactyly (HP:0010554)1.62345403
19411 pairs of ribs (HP:0000878)1.61854539
195Abnormality of the hip-girdle musculature (HP:0001445)1.60456246
196Abnormality of the musculature of the pelvis (HP:0001469)1.60456246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.80398033
2CDC74.46165409
3SRPK13.16034325
4WEE13.05841998
5GRK12.98058338
6CDK122.86107173
7ADRBK22.84000362
8BMPR1B2.81993027
9LATS22.78626245
10BUB12.69738855
11TTK2.63769193
12ZAK2.50444171
13NEK12.47159659
14CASK2.43400056
15NEK22.43003226
16LATS12.42898220
17STK38L2.15441596
18MKNK12.12374225
19NUAK12.01972812
20PASK2.00954401
21WNK41.99974536
22PLK41.93487183
23PLK31.93434553
24TSSK61.91130829
25TNIK1.90801577
26PLK11.88377912
27TAOK31.86793395
28PINK11.86118597
29CHEK21.80738403
30RPS6KB21.79129462
31PNCK1.72819292
32SGK21.63195679
33TGFBR11.55826242
34PHKG21.55425403
35PHKG11.55425403
36DYRK31.55281636
37AURKB1.52685650
38STK391.52474847
39MKNK21.49310940
40OXSR11.46599520
41CDK71.46528805
42MAP4K21.40860431
43MAPK131.39528226
44CHEK11.38454961
45ATR1.38275408
46INSRR1.37742045
47BRSK21.34368784
48BRD41.30347295
49ACVR1B1.28041748
50SGK2231.27723195
51SGK4941.27723195
52AURKA1.26855970
53KSR11.25705286
54FGFR11.25012350
55ERBB31.24809984
56NTRK31.22422767
57PLK21.21515356
58TLK11.20319968
59BCR1.19560383
60ATM1.17495176
61DYRK21.15747690
62MST41.09975285
63PAK41.09920778
64CDK61.09704233
65MAP3K81.07430142
66CSNK1G31.06241909
67EPHA21.05906447
68TAF11.05680470
69STK161.03051949
70ADRBK11.02855792
71MELK1.01351575
72SCYL21.00975123
73NEK91.00666428
74CDK21.00371625
75PRKCG0.99263303
76PAK30.99032489
77VRK10.98793010
78CDK40.98227690
79STK30.97065374
80EEF2K0.96784425
81MAP3K100.96632491
82MAP2K70.95897173
83DAPK20.93279850
84ALK0.92851788
85PRKCE0.91852776
86GRK70.91695729
87TYRO30.90535137
88EPHB20.89820054
89CSNK1G10.87315398
90NTRK20.86781490
91CDK10.84007635
92MAP3K90.82379033
93PIK3CA0.82267268
94ICK0.82125196
95RPS6KA60.81194773
96CSNK1E0.80825516
97SGK10.79058469
98SGK30.77585226
99CDK190.77378070
100TEC0.76769823
101CSNK1G20.76321156
102NLK0.76239160
103BRSK10.75837205
104MUSK0.75536089
105CSNK1D0.74772526
106WNK30.74510233
107TXK0.74135149
108MARK10.73633166
109MTOR0.71855543
110PDGFRA0.71323146
111CSNK1A1L0.70813638
112PRKACA0.70117065
113OBSCN0.70051004
114EIF2AK10.69733787
115MAPKAPK50.69452378
116CDK80.68176008
117AKT20.66855039
118STK100.66066458
119PKN10.66060593
120AKT30.64665326
121RPS6KA40.64239000
122PKN20.63616127
123GRK50.63439542
124RPS6KA20.62817867
125CSNK2A20.62286870
126ERBB40.59892496
127CAMK2A0.59812316
128CSNK1A10.57496288
129PRKCI0.57385804
130TIE10.55792403
131PTK2B0.54181172
132PRKDC0.53466044
133CDK90.51678668
134RPS6KA50.51488665
135WNK10.50097264
136RPS6KC10.49704110
137RPS6KL10.49704110
138MAPK150.47781251
139DYRK1A0.47290064
140STK110.46388873
141CSNK2A10.45959748
142FGFR20.45871506
143IKBKB0.45609350
144ERBB20.44869809
145BRAF0.44290258
146UHMK10.43633906
147MAPK140.43002964
148STK40.41524477
149FER0.40075928
150RPS6KA30.38763773
151GSK3B0.38630795
152PRKD30.38314775
153MAP2K20.38046235
154PRKCA0.37863677
155PRKG10.37716500
156MAP2K10.36588698
157CAMKK20.36222984
158PAK10.36045899
159EIF2AK30.35739461
160PRKACG0.35662830
161EPHA40.35220062
162AKT10.34876022
163MAP3K40.33495620
164PRKCQ0.33464461
165CDK180.33251923
166MAPK100.31963679
167CDK140.31892246
168CDK150.31849782
169CAMK10.31812381
170PDK40.31434055
171PDK30.31434055

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.95691914
2DNA replication_Homo sapiens_hsa030303.87531877
3RNA transport_Homo sapiens_hsa030133.57432363
4Spliceosome_Homo sapiens_hsa030403.52714844
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45808532
6Cell cycle_Homo sapiens_hsa041103.28078635
7mRNA surveillance pathway_Homo sapiens_hsa030152.69657079
8Nicotine addiction_Homo sapiens_hsa050332.67051650
9Nucleotide excision repair_Homo sapiens_hsa034202.52794050
10One carbon pool by folate_Homo sapiens_hsa006702.50221820
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.43543478
12Ribosome_Homo sapiens_hsa030102.39906899
13RNA polymerase_Homo sapiens_hsa030202.39199628
14Homologous recombination_Homo sapiens_hsa034402.37899388
15Fanconi anemia pathway_Homo sapiens_hsa034602.35425499
16Base excision repair_Homo sapiens_hsa034102.33396241
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32475463
18Basal cell carcinoma_Homo sapiens_hsa052172.25776380
19Protein export_Homo sapiens_hsa030602.21529599
20RNA degradation_Homo sapiens_hsa030182.17645504
21Oxidative phosphorylation_Homo sapiens_hsa001902.15815090
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.07147685
23Phototransduction_Homo sapiens_hsa047442.04043779
24Basal transcription factors_Homo sapiens_hsa030222.03597278
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03574590
26Hippo signaling pathway_Homo sapiens_hsa043902.01996858
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.01512304
28Systemic lupus erythematosus_Homo sapiens_hsa053222.00121732
29Linoleic acid metabolism_Homo sapiens_hsa005911.95472494
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94591358
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.85206849
32* Oocyte meiosis_Homo sapiens_hsa041141.84568817
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82275432
34Hedgehog signaling pathway_Homo sapiens_hsa043401.77155452
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75473972
36Morphine addiction_Homo sapiens_hsa050321.71831632
37Non-homologous end-joining_Homo sapiens_hsa034501.71251564
38Vitamin digestion and absorption_Homo sapiens_hsa049771.68457242
39Retinol metabolism_Homo sapiens_hsa008301.67583428
40Parkinsons disease_Homo sapiens_hsa050121.62612411
41p53 signaling pathway_Homo sapiens_hsa041151.62476508
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60238042
43Proteasome_Homo sapiens_hsa030501.59958215
44Taste transduction_Homo sapiens_hsa047421.59137217
45Pyrimidine metabolism_Homo sapiens_hsa002401.58779078
46* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.57033703
47Nitrogen metabolism_Homo sapiens_hsa009101.56490596
48Caffeine metabolism_Homo sapiens_hsa002321.55820474
49Cardiac muscle contraction_Homo sapiens_hsa042601.55671066
50Sulfur metabolism_Homo sapiens_hsa009201.54587098
51TGF-beta signaling pathway_Homo sapiens_hsa043501.52916128
52Chemical carcinogenesis_Homo sapiens_hsa052041.48799941
53Insulin secretion_Homo sapiens_hsa049111.48037096
54Circadian entrainment_Homo sapiens_hsa047131.44959326
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44067186
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.43764495
57Alcoholism_Homo sapiens_hsa050341.42870736
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42122058
59Serotonergic synapse_Homo sapiens_hsa047261.40200849
60MicroRNAs in cancer_Homo sapiens_hsa052061.40053075
61Tryptophan metabolism_Homo sapiens_hsa003801.39228003
62Glutamatergic synapse_Homo sapiens_hsa047241.38912435
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36751192
64Alzheimers disease_Homo sapiens_hsa050101.33310201
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32535781
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29304868
67Butanoate metabolism_Homo sapiens_hsa006501.22736450
68Adherens junction_Homo sapiens_hsa045201.20096935
69GABAergic synapse_Homo sapiens_hsa047271.19502177
70Viral carcinogenesis_Homo sapiens_hsa052031.17795132
71Tight junction_Homo sapiens_hsa045301.16837910
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13837887
73Intestinal immune network for IgA production_Homo sapiens_hsa046721.12710068
74Thyroid cancer_Homo sapiens_hsa052161.11527402
75Wnt signaling pathway_Homo sapiens_hsa043101.09935378
76Colorectal cancer_Homo sapiens_hsa052101.09918033
77Ether lipid metabolism_Homo sapiens_hsa005651.09696195
78Primary bile acid biosynthesis_Homo sapiens_hsa001201.09435845
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08828021
80Cholinergic synapse_Homo sapiens_hsa047251.03179327
81Renin secretion_Homo sapiens_hsa049241.01964387
82Olfactory transduction_Homo sapiens_hsa047401.01310765
83Gastric acid secretion_Homo sapiens_hsa049711.00170280
84Propanoate metabolism_Homo sapiens_hsa006400.94702809
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93732319
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93647796
87Calcium signaling pathway_Homo sapiens_hsa040200.92732992
88Epstein-Barr virus infection_Homo sapiens_hsa051690.92417978
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.89258803
90Notch signaling pathway_Homo sapiens_hsa043300.89135476
91HTLV-I infection_Homo sapiens_hsa051660.86498736
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83779313
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81093621
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80811431
95Regulation of autophagy_Homo sapiens_hsa041400.79606978
96Peroxisome_Homo sapiens_hsa041460.79585928
97Purine metabolism_Homo sapiens_hsa002300.79509798
98Amphetamine addiction_Homo sapiens_hsa050310.76197208
99Salivary secretion_Homo sapiens_hsa049700.75676911
100Biosynthesis of amino acids_Homo sapiens_hsa012300.75535095
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.74694713
102Circadian rhythm_Homo sapiens_hsa047100.73279549
103Glycerolipid metabolism_Homo sapiens_hsa005610.72032327
104Arachidonic acid metabolism_Homo sapiens_hsa005900.71329515
105Endometrial cancer_Homo sapiens_hsa052130.70654118
106Pathways in cancer_Homo sapiens_hsa052000.70431730
107Oxytocin signaling pathway_Homo sapiens_hsa049210.70313892
108Melanogenesis_Homo sapiens_hsa049160.67338059
109Cocaine addiction_Homo sapiens_hsa050300.65857765
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65832441
111cAMP signaling pathway_Homo sapiens_hsa040240.65174506
112Small cell lung cancer_Homo sapiens_hsa052220.65021634
113Selenocompound metabolism_Homo sapiens_hsa004500.62365219
114Axon guidance_Homo sapiens_hsa043600.61966885
115Type II diabetes mellitus_Homo sapiens_hsa049300.61140454
116Bladder cancer_Homo sapiens_hsa052190.60228918
117Ovarian steroidogenesis_Homo sapiens_hsa049130.59150545
118* mTOR signaling pathway_Homo sapiens_hsa041500.58719548
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58188962
120Prostate cancer_Homo sapiens_hsa052150.57408982
121Proteoglycans in cancer_Homo sapiens_hsa052050.55480226
122Mineral absorption_Homo sapiens_hsa049780.55419594
123beta-Alanine metabolism_Homo sapiens_hsa004100.55132302
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55058515
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.53478639
126Lysine degradation_Homo sapiens_hsa003100.53130869
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53106820
128ABC transporters_Homo sapiens_hsa020100.52897520
129Melanoma_Homo sapiens_hsa052180.51937807
130Herpes simplex infection_Homo sapiens_hsa051680.51003355
131Asthma_Homo sapiens_hsa053100.50966619
132Long-term depression_Homo sapiens_hsa047300.47148366
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47084666
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.46832781
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46505372
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43114129
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43024357
138Metabolic pathways_Homo sapiens_hsa011000.42746977
139Histidine metabolism_Homo sapiens_hsa003400.42729861
140Starch and sucrose metabolism_Homo sapiens_hsa005000.38669878
141Renal cell carcinoma_Homo sapiens_hsa052110.36293883
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35529364
143Chronic myeloid leukemia_Homo sapiens_hsa052200.34471304
144Viral myocarditis_Homo sapiens_hsa054160.33793381
145ErbB signaling pathway_Homo sapiens_hsa040120.31787964
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29995671
147Gap junction_Homo sapiens_hsa045400.29376815
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28036163
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27128441
150Estrogen signaling pathway_Homo sapiens_hsa049150.26602207
151HIF-1 signaling pathway_Homo sapiens_hsa040660.26251978
152Huntingtons disease_Homo sapiens_hsa050160.26219043
153FoxO signaling pathway_Homo sapiens_hsa040680.25410945
154AMPK signaling pathway_Homo sapiens_hsa041520.25148520
155Rap1 signaling pathway_Homo sapiens_hsa040150.23930430
156Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21771290
157Non-small cell lung cancer_Homo sapiens_hsa052230.21542943
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20751126
159Glucagon signaling pathway_Homo sapiens_hsa049220.16886390
160Antigen processing and presentation_Homo sapiens_hsa046120.16678336
161Glioma_Homo sapiens_hsa052140.15657377
162Dorso-ventral axis formation_Homo sapiens_hsa043200.15127725
163Pancreatic cancer_Homo sapiens_hsa052120.12671677
164Glutathione metabolism_Homo sapiens_hsa004800.10780408
165Carbon metabolism_Homo sapiens_hsa012000.10763051
166Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10496327
167Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10319360
168Dopaminergic synapse_Homo sapiens_hsa047280.08873292
169Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08872218
1702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.08770629
171Focal adhesion_Homo sapiens_hsa045100.08572005
172Regulation of actin cytoskeleton_Homo sapiens_hsa048100.07242156
173Insulin signaling pathway_Homo sapiens_hsa049100.05051706
174Ras signaling pathway_Homo sapiens_hsa040140.04881842
175Hepatitis B_Homo sapiens_hsa051610.04728842
176Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.03716305

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