RPS6KC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.27245105
2synaptic vesicle maturation (GO:0016188)4.78272219
3nuclear pore organization (GO:0006999)4.59731296
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.49281687
5pore complex assembly (GO:0046931)4.22776780
6COPI coating of Golgi vesicle (GO:0048205)4.21374136
7Golgi transport vesicle coating (GO:0048200)4.21374136
8COPII vesicle coating (GO:0048208)4.19392781
9locomotory exploration behavior (GO:0035641)4.19089067
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.11900747
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.02188810
12layer formation in cerebral cortex (GO:0021819)4.01582536
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97601927
14synaptic vesicle exocytosis (GO:0016079)3.94262998
15glutamate secretion (GO:0014047)3.92703371
16regulation of synaptic vesicle exocytosis (GO:2000300)3.91108238
17vocalization behavior (GO:0071625)3.81313624
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.74976536
19regulation of synapse structural plasticity (GO:0051823)3.61389140
20neuron cell-cell adhesion (GO:0007158)3.60666420
21activation of protein kinase A activity (GO:0034199)3.57455252
22vesicle coating (GO:0006901)3.54050680
23regulation of mitotic spindle organization (GO:0060236)3.47430866
24protein localization to synapse (GO:0035418)3.44975430
25regulation of glutamate receptor signaling pathway (GO:1900449)3.42717151
26exploration behavior (GO:0035640)3.39994092
27proline transport (GO:0015824)3.37679859
28regulation of synaptic vesicle transport (GO:1902803)3.34190487
29cell adhesion mediated by integrin (GO:0033627)3.31765438
30regulation of neuronal synaptic plasticity (GO:0048168)3.30036182
31negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.29582016
32axonal fasciculation (GO:0007413)3.26068412
33vesicle transport along microtubule (GO:0047496)3.19447588
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18943175
35dendritic spine morphogenesis (GO:0060997)3.15889514
36neurotransmitter-gated ion channel clustering (GO:0072578)3.13666832
37neuron recognition (GO:0008038)3.12131242
38dendrite morphogenesis (GO:0048813)3.11535011
39clathrin coat assembly (GO:0048268)3.09808802
40neurotransmitter secretion (GO:0007269)3.09178111
41positive regulation of synapse maturation (GO:0090129)3.04640232
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02594395
43regulation of long-term neuronal synaptic plasticity (GO:0048169)2.98452060
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.97728018
45cellular potassium ion homeostasis (GO:0030007)2.95106162
46neuromuscular process controlling balance (GO:0050885)2.93462044
47establishment of chromosome localization (GO:0051303)2.92058093
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92004388
49regulation of voltage-gated calcium channel activity (GO:1901385)2.90928015
50regulation of nucleobase-containing compound transport (GO:0032239)2.89786531
51neuronal action potential propagation (GO:0019227)2.89720922
52monoubiquitinated protein deubiquitination (GO:0035520)2.89586625
53cerebellar Purkinje cell differentiation (GO:0021702)2.89181083
54regulation of RNA export from nucleus (GO:0046831)2.89169716
55cytoskeletal anchoring at plasma membrane (GO:0007016)2.84891766
56nerve growth factor signaling pathway (GO:0038180)2.84128070
57regulation of NFAT protein import into nucleus (GO:0051532)2.82312675
58regulation of early endosome to late endosome transport (GO:2000641)2.78847089
59morphogenesis of an epithelial sheet (GO:0002011)2.78455982
60regulation of clathrin-mediated endocytosis (GO:2000369)2.78316597
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.77885925
62ionotropic glutamate receptor signaling pathway (GO:0035235)2.77729460
63protein targeting to vacuole (GO:0006623)2.77440581
64protein targeting to lysosome (GO:0006622)2.77440581
65establishment of protein localization to vacuole (GO:0072666)2.77440581
66negative regulation of DNA repair (GO:0045738)2.75058194
67mating behavior (GO:0007617)2.73736535
68centrosome duplication (GO:0051298)2.73627952
69regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73511053
70cerebellar Purkinje cell layer development (GO:0021680)2.73224209
71synaptic vesicle endocytosis (GO:0048488)2.73091748
72organelle transport along microtubule (GO:0072384)2.72896917
73sodium ion export (GO:0071436)2.72755116
74alanine transport (GO:0032328)2.72031834
75iron ion import (GO:0097286)2.70561431
76protein localization to endosome (GO:0036010)2.70159233
77regulation of postsynaptic membrane potential (GO:0060078)2.70058997
78protein targeting to Golgi (GO:0000042)2.69902015
79cell migration in hindbrain (GO:0021535)2.69573943
80negative regulation of vascular permeability (GO:0043116)2.68944042
81regulation of synaptic plasticity (GO:0048167)2.68312499
82retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67434909
83response to auditory stimulus (GO:0010996)2.66670601
84glutamate receptor signaling pathway (GO:0007215)2.66612221
85regulation of centriole replication (GO:0046599)2.66100049
86regulation of spindle organization (GO:0090224)2.65431872
87establishment of protein localization to Golgi (GO:0072600)2.63013566
88membrane depolarization during action potential (GO:0086010)2.62846808
89histone H3-K9 demethylation (GO:0033169)2.62546852
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.61936651
91plasma membrane repair (GO:0001778)2.61768409
92retrograde transport, vesicle recycling within Golgi (GO:0000301)2.61133153
93mitotic G2 DNA damage checkpoint (GO:0007095)2.60279929
94regulation of neurotransmitter secretion (GO:0046928)2.59451239
95establishment of nucleus localization (GO:0040023)2.59296017
96cell communication by electrical coupling (GO:0010644)2.58945657
97negative regulation of microtubule polymerization (GO:0031115)2.58938802
98regulation of dendritic spine morphogenesis (GO:0061001)2.58634178
99interkinetic nuclear migration (GO:0022027)2.56899259
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.56379943
101cellular response to interferon-alpha (GO:0035457)2.55163162
102stress fiber assembly (GO:0043149)2.53565680
103chondrocyte development (GO:0002063)2.52925543
104axon extension (GO:0048675)2.52215798
105L-amino acid import (GO:0043092)2.51824908
106prepulse inhibition (GO:0060134)2.51706969
107regulation of dendritic spine development (GO:0060998)2.51557901
108auditory behavior (GO:0031223)2.51497331
109mitotic sister chromatid cohesion (GO:0007064)2.51467291
110regulation of fever generation (GO:0031620)2.49676632
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.49636816
112membrane hyperpolarization (GO:0060081)2.49363447
113metaphase plate congression (GO:0051310)2.49013991
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48667532
115interleukin-6-mediated signaling pathway (GO:0070102)2.48164802
116intra-Golgi vesicle-mediated transport (GO:0006891)2.48101794
117positive regulation of axon extension (GO:0045773)2.47683779
118membrane depolarization (GO:0051899)2.46926095
119innervation (GO:0060384)2.46085580
120long-term synaptic potentiation (GO:0060291)2.45469562
121regulation of ARF protein signal transduction (GO:0032012)2.43387920
122positive regulation of neurotransmitter transport (GO:0051590)2.43237222
123long-term memory (GO:0007616)2.43111125
124neuron-neuron synaptic transmission (GO:0007270)2.43055415
125anterior/posterior axis specification, embryo (GO:0008595)2.42891955
126synaptic transmission, glutamatergic (GO:0035249)2.42619998
127macroautophagy (GO:0016236)2.42356783
128neuromuscular process controlling posture (GO:0050884)2.41996165
129regulation of transforming growth factor beta2 production (GO:0032909)2.41845903
130sensory perception of smell (GO:0007608)2.41794056
131positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41789395
132mitotic G2/M transition checkpoint (GO:0044818)2.41743665
133adult walking behavior (GO:0007628)2.41216832
134neurotransmitter transport (GO:0006836)2.40604544
135collagen fibril organization (GO:0030199)2.40490164
136regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.40420080
137positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.40420080
138maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.40244868
139regulation of ARF GTPase activity (GO:0032312)2.40211270
140neuron projection extension (GO:1990138)2.39408118
141gamma-aminobutyric acid transport (GO:0015812)2.39149434
142response to histamine (GO:0034776)2.37168781
143long-chain fatty acid biosynthetic process (GO:0042759)2.36987331
144Golgi organization (GO:0007030)2.36051140
145amino acid import (GO:0043090)2.34970139
146gamma-aminobutyric acid signaling pathway (GO:0007214)2.34943786
147establishment of spindle orientation (GO:0051294)2.34836461
148regulation of neurotransmitter transport (GO:0051588)2.34694773
149positive regulation of astrocyte differentiation (GO:0048711)2.34570087
150UDP-N-acetylglucosamine metabolic process (GO:0006047)2.34288794
151neuromuscular process (GO:0050905)2.33434653
152positive regulation of fibroblast migration (GO:0010763)2.32917604
153negative regulation of dendrite development (GO:2000171)2.32886410
154positive regulation of neurotransmitter secretion (GO:0001956)2.31649957
155positive regulation of membrane potential (GO:0045838)2.31552391
156positive regulation of protein import into nucleus, translocation (GO:0033160)2.30026029
157oligosaccharide catabolic process (GO:0009313)2.29584196
158Golgi to plasma membrane protein transport (GO:0043001)2.26139991
159melanin biosynthetic process (GO:0042438)2.25816305
160Golgi to plasma membrane transport (GO:0006893)2.24536695
161regulation of cAMP-dependent protein kinase activity (GO:2000479)2.23296592
162protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.22501538
163negative regulation of protein localization to plasma membrane (GO:1903077)2.22115173
164Notch signaling involved in heart development (GO:0061314)2.21517305
165embryonic viscerocranium morphogenesis (GO:0048703)2.21241579
166lipid translocation (GO:0034204)2.20965160
167phospholipid translocation (GO:0045332)2.20965160
168hepatocyte differentiation (GO:0070365)2.20708364
169mitotic metaphase plate congression (GO:0007080)2.20551017
170regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.20173388
171ganglion development (GO:0061548)2.19079584
172cytoskeleton-dependent cytokinesis (GO:0061640)2.18651098
173ribonucleoprotein complex disassembly (GO:0032988)2.18080825
174microtubule anchoring (GO:0034453)2.17565613
175substrate adhesion-dependent cell spreading (GO:0034446)2.17186375
176cortical cytoskeleton organization (GO:0030865)2.16985380
177positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.16976739
178regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.16827959
179protein localization to cell surface (GO:0034394)2.16644320
180positive regulation of muscle hypertrophy (GO:0014742)2.15497220
181positive regulation of cardiac muscle hypertrophy (GO:0010613)2.15497220
182cortical actin cytoskeleton organization (GO:0030866)2.15496702
183ER to Golgi vesicle-mediated transport (GO:0006888)2.14867209
184negative regulation of NF-kappaB import into nucleus (GO:0042347)2.13863661
185protein retention in ER lumen (GO:0006621)2.13766455
186corticosteroid receptor signaling pathway (GO:0031958)2.13544916
187peptidyl-threonine modification (GO:0018210)2.13034544
188sister chromatid segregation (GO:0000819)2.12909686
189alpha-linolenic acid metabolic process (GO:0036109)2.12162598
190osteoclast differentiation (GO:0030316)2.11871825
191nucleus localization (GO:0051647)2.10576950
192negative regulation of receptor-mediated endocytosis (GO:0048261)2.09471137
193histone H2B ubiquitination (GO:0033523)2.07530718
194glomerular visceral epithelial cell development (GO:0072015)2.07431621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.39224355
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.27491354
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.10506049
4WT1_19549856_ChIP-ChIP_CCG9911_Human2.75727744
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75231514
6DROSHA_22980978_ChIP-Seq_HELA_Human2.55790341
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42781152
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30108435
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28323249
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.27862284
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.24672892
12* GBX2_23144817_ChIP-Seq_PC3_Human2.19434122
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17554458
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17554458
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14462514
16PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.12426290
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08556821
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07665319
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.07297881
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07219114
21FUS_26573619_Chip-Seq_HEK293_Human2.05565439
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04517508
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03653559
24AR_21909140_ChIP-Seq_LNCAP_Human2.01180459
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.01080000
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00290615
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99436460
28GATA1_22025678_ChIP-Seq_K562_Human1.97697879
29* REST_21632747_ChIP-Seq_MESCs_Mouse1.95901071
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95448307
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93742687
32IGF1R_20145208_ChIP-Seq_DFB_Human1.93721024
33BRD4_25478319_ChIP-Seq_HGPS_Human1.92520061
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85716319
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.83345834
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83175908
37AR_21572438_ChIP-Seq_LNCaP_Human1.79778383
38* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77425809
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76244227
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.74996699
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.72866191
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71986343
43KDM2B_26808549_Chip-Seq_K562_Human1.70047062
44* NANOG_18555785_Chip-Seq_ESCs_Mouse1.66426497
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65661111
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.65147436
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.62394369
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.61036241
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.60421952
50SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59007252
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54829897
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.53219917
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.52475757
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51138154
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50236612
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48635985
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48589091
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47728565
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47704093
60* E2F1_18555785_Chip-Seq_ESCs_Mouse1.46904325
61CJUN_26792858_Chip-Seq_BT549_Human1.42362720
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42168331
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41097501
64* EZH2_27294783_Chip-Seq_NPCs_Mouse1.40784233
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.40255667
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37894276
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37386569
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37192508
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34779411
70EWS_26573619_Chip-Seq_HEK293_Human1.34341119
71CLOCK_20551151_ChIP-Seq_293T_Human1.33986258
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33617397
73* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32206645
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31978614
75TP53_16413492_ChIP-PET_HCT116_Human1.31096289
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30439924
77* CMYC_18555785_Chip-Seq_ESCs_Mouse1.29594700
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28548667
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28283724
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.27837186
81* SMAD4_21799915_ChIP-Seq_A2780_Human1.27815666
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27641350
83ZNF274_21170338_ChIP-Seq_K562_Hela1.26819775
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26781110
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26709292
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26110876
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26001181
88* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25858978
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25449319
90* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24718640
91ELK1_19687146_ChIP-ChIP_HELA_Human1.24263132
92TP53_18474530_ChIP-ChIP_U2OS_Human1.21059028
93* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20931709
94* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20313763
95* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19394234
96ZNF263_19887448_ChIP-Seq_K562_Human1.19317717
97AHR_22903824_ChIP-Seq_MCF-7_Human1.18467169
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17737771
99* P53_22387025_ChIP-Seq_ESCs_Mouse1.16907085
100RXR_22108803_ChIP-Seq_LS180_Human1.16590716
101* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16553167
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16506208
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.15348732
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.14812517
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.13751791
106* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13220573
107* SOX2_18555785_Chip-Seq_ESCs_Mouse1.12702083
108* AR_19668381_ChIP-Seq_PC3_Human1.12577514
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12008651
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11902325
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11202334
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11093720
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10381508
114* NMYC_18555785_Chip-Seq_ESCs_Mouse1.10322870
115* P300_18555785_Chip-Seq_ESCs_Mouse1.09500899
116MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09164390
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08860807
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08805049
119* TAF15_26573619_Chip-Seq_HEK293_Human1.08289628
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08251319
121ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08212674
122JUN_21703547_ChIP-Seq_K562_Human1.07873060
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06691617
124NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06691617
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06404921
126* TCF4_23295773_ChIP-Seq_U87_Human1.05839436
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05746797
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05690097
129* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05436329
130* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05391296
131* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05153796
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04640312
133SOX9_26525672_Chip-Seq_HEART_Mouse1.03322658
134TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02821566
135SMAD3_21741376_ChIP-Seq_EPCs_Human1.02730942
136PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02724358
137* CRX_20693478_ChIP-Seq_RETINA_Mouse1.02238797
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01968933
139TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01633538
140* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00255713
141* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99632413
142* OCT4_18555785_Chip-Seq_ESCs_Mouse0.99533712
143STAT3_23295773_ChIP-Seq_U87_Human0.99264469
144KDM2B_26808549_Chip-Seq_DND41_Human0.98527130
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98030482
146* RING1B_27294783_Chip-Seq_ESCs_Mouse0.97697518
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.97631371
148RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97480162
149* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97127848
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96794048
151* SMAD3_21741376_ChIP-Seq_ESCs_Human0.95922562
152EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95836350
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.95314960
154* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95196439
155TRIM28_21343339_ChIP-Seq_HEK293_Human0.95031397
156KDM2B_26808549_Chip-Seq_JURKAT_Human0.94128225
157* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93806305
158P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92034328
159YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90958928
160P300_19829295_ChIP-Seq_ESCs_Human0.90914084
161CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90471107
162AR_25329375_ChIP-Seq_VCAP_Human0.89407646
163TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89238705
164RING1B_27294783_Chip-Seq_NPCs_Mouse0.88947263
165SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88759407
166RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87700932
167* SMAD3_21741376_ChIP-Seq_HESCs_Human0.86616921
168P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84633548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.29100314
2MP0003880_abnormal_central_pattern4.00850922
3MP0000569_abnormal_digit_pigmentation3.98932970
4MP0004270_analgesia3.32376123
5MP0003635_abnormal_synaptic_transmissio3.27708858
6MP0008057_abnormal_DNA_replication2.95680290
7MP0002877_abnormal_melanocyte_morpholog2.83221843
8MP0006054_spinal_hemorrhage2.80220544
9MP0002063_abnormal_learning/memory/cond2.59347401
10MP0003329_amyloid_beta_deposits2.58864044
11MP0004272_abnormal_basement_membrane2.55581517
12MP0002064_seizures2.49396103
13MP0009046_muscle_twitch2.44811200
14MP0004858_abnormal_nervous_system2.43099554
15MP0009745_abnormal_behavioral_response2.33969183
16MP0003950_abnormal_plasma_membrane2.33280029
17MP0002734_abnormal_mechanical_nocicepti2.33051386
18MP0001968_abnormal_touch/_nociception2.23294057
19MP0010352_gastrointestinal_tract_polyps2.22604313
20MP0003890_abnormal_embryonic-extraembry2.21646141
21MP0003183_abnormal_peptide_metabolism2.20700227
22MP0005171_absent_coat_pigmentation2.20142977
23MP0000604_amyloidosis2.18380850
24MP0009840_abnormal_foam_cell2.06528264
25MP0009780_abnormal_chondrocyte_physiolo2.03888566
26MP0005423_abnormal_somatic_nervous2.01155432
27MP0002572_abnormal_emotion/affect_behav2.00954569
28MP0001984_abnormal_olfaction2.00351245
29MP0005623_abnormal_meninges_morphology1.97497209
30MP0001486_abnormal_startle_reflex1.96925877
31MP0003941_abnormal_skin_development1.92123844
32MP0002909_abnormal_adrenal_gland1.90925977
33MP0005058_abnormal_lysosome_morphology1.90811561
34MP0000751_myopathy1.83623225
35MP0002736_abnormal_nociception_after1.80519365
36MP0003705_abnormal_hypodermis_morpholog1.79268939
37MP0002272_abnormal_nervous_system1.77535763
38MP0003221_abnormal_cardiomyocyte_apopto1.76176308
39MP0002733_abnormal_thermal_nociception1.75398287
40MP0004811_abnormal_neuron_physiology1.70449105
41MP0003690_abnormal_glial_cell1.67858240
42MP0003075_altered_response_to1.66783079
43MP0003656_abnormal_erythrocyte_physiolo1.66011848
44MP0002332_abnormal_exercise_endurance1.64106318
45MP0001970_abnormal_pain_threshold1.63315805
46MP0002735_abnormal_chemical_nociception1.63246221
47MP0001440_abnormal_grooming_behavior1.61232294
48MP0004510_myositis1.60299281
49MP0003566_abnormal_cell_adhesion1.57484855
50MP0000778_abnormal_nervous_system1.57277494
51MP0003633_abnormal_nervous_system1.55217093
52MP0002184_abnormal_innervation1.52388160
53MP0005076_abnormal_cell_differentiation1.51904113
54MP0001501_abnormal_sleep_pattern1.51387015
55MP0002067_abnormal_sensory_capabilities1.46888256
56MP0001348_abnormal_lacrimal_gland1.46227445
57MP0003303_peritoneal_inflammation1.44248037
58MP0008438_abnormal_cutaneous_collagen1.42860724
59MP0009697_abnormal_copulation1.38376842
60MP0005275_abnormal_skin_tensile1.36075864
61MP0002090_abnormal_vision1.34498062
62MP0003634_abnormal_glial_cell1.33021016
63MP0005248_abnormal_Harderian_gland1.32830900
64MP0000955_abnormal_spinal_cord1.29844572
65MP0001915_intracranial_hemorrhage1.29748451
66MP0002822_catalepsy1.29637159
67MP0000749_muscle_degeneration1.27839570
68MP0002557_abnormal_social/conspecific_i1.25632656
69MP0003172_abnormal_lysosome_physiology1.25063567
70MP0000015_abnormal_ear_pigmentation1.24250480
71MP0000371_diluted_coat_color1.22422860
72MP0001299_abnormal_eye_distance/1.21933479
73MP0005386_behavior/neurological_phenoty1.21698027
74MP0004924_abnormal_behavior1.21698027
75MP0003385_abnormal_body_wall1.21475781
76MP0008932_abnormal_embryonic_tissue1.21153720
77MP0003077_abnormal_cell_cycle1.20825472
78MP0002882_abnormal_neuron_morphology1.20026216
79MP0002269_muscular_atrophy1.19787140
80MP0005621_abnormal_cell_physiology1.18854667
81MP0004957_abnormal_blastocyst_morpholog1.18672923
82MP0008569_lethality_at_weaning1.17997255
83MP0004084_abnormal_cardiac_muscle1.17655940
84MP0004145_abnormal_muscle_electrophysio1.17021002
85MP0003631_nervous_system_phenotype1.16505435
86MP0005451_abnormal_body_composition1.16139271
87MP0005408_hypopigmentation1.15663997
88MP0004130_abnormal_muscle_cell1.11982901
89MP0004808_abnormal_hematopoietic_stem1.10650078
90MP0002066_abnormal_motor_capabilities/c1.10495925
91MP0003279_aneurysm1.09755840
92MP0004885_abnormal_endolymph1.08604316
93MP0006276_abnormal_autonomic_nervous1.05772571
94MP0005645_abnormal_hypothalamus_physiol1.05493323
95MP0000013_abnormal_adipose_tissue1.04406342
96MP0000920_abnormal_myelination1.04067514
97MP0001730_embryonic_growth_arrest1.02729780
98MP0004036_abnormal_muscle_relaxation0.99553243
99MP0003879_abnormal_hair_cell0.98906562
100MP0003091_abnormal_cell_migration0.97905775
101MP0004233_abnormal_muscle_weight0.97078793
102MP0002084_abnormal_developmental_patter0.96261456
103MP0000428_abnormal_craniofacial_morphol0.96172495
104MP0002009_preneoplasia0.93401500
105MP0005384_cellular_phenotype0.93321470
106MP0003283_abnormal_digestive_organ0.93110001
107MP0000747_muscle_weakness0.92119843
108MP0001672_abnormal_embryogenesis/_devel0.91107541
109MP0005380_embryogenesis_phenotype0.91107541
110MP0008004_abnormal_stomach_pH0.90086733
111MP0001958_emphysema0.89302208
112MP0002152_abnormal_brain_morphology0.89094355
113MP0003632_abnormal_nervous_system0.87754018
114MP0008874_decreased_physiological_sensi0.87602454
115MP0005166_decreased_susceptibility_to0.85699876
116MP0002229_neurodegeneration0.85419480
117MP0005197_abnormal_uvea_morphology0.85137313
118MP0005174_abnormal_tail_pigmentation0.84957955
119MP0003937_abnormal_limbs/digits/tail_de0.84825514
120MP0002896_abnormal_bone_mineralization0.84016341
121MP0010307_abnormal_tumor_latency0.84013389
122MP0005551_abnormal_eye_electrophysiolog0.83833913
123MP0003045_fibrosis0.82844629
124MP0000733_abnormal_muscle_development0.81918684
125MP0008260_abnormal_autophagy0.81856716
126MP0005167_abnormal_blood-brain_barrier0.81645576
127MP0003984_embryonic_growth_retardation0.81132874
128MP0003448_altered_tumor_morphology0.80406787
129MP0002086_abnormal_extraembryonic_tissu0.80216517
130MP0000372_irregular_coat_pigmentation0.79107104
131MP0005395_other_phenotype0.78675767
132MP0004134_abnormal_chest_morphology0.78388788
133MP0003122_maternal_imprinting0.77869975
134MP0002088_abnormal_embryonic_growth/wei0.77187107
135MP0002177_abnormal_outer_ear0.74149186
136MP0002972_abnormal_cardiac_muscle0.73760004
137MP0003718_maternal_effect0.73560803
138MP0008007_abnormal_cellular_replicative0.73523531
139MP0002168_other_aberrant_phenotype0.73431758
140MP0000767_abnormal_smooth_muscle0.73391994
141MP0006138_congestive_heart_failure0.72453329
142MP0002837_dystrophic_cardiac_calcinosis0.72435119
143MP0001661_extended_life_span0.72283967
144MP0010386_abnormal_urinary_bladder0.71535722
145MP0009703_decreased_birth_body0.70970656
146MP0002163_abnormal_gland_morphology0.70608065
147MP0004197_abnormal_fetal_growth/weight/0.70330559
148MP0000350_abnormal_cell_proliferation0.70003377
149MP0010234_abnormal_vibrissa_follicle0.69907032
150MP0005646_abnormal_pituitary_gland0.69861627
151MP0004883_abnormal_blood_vessel0.69611735
152MP0002092_abnormal_eye_morphology0.68719321
153MP0005187_abnormal_penis_morphology0.68676768
154MP0003300_gastrointestinal_ulcer0.68230798
155MP0009384_cardiac_valve_regurgitation0.67682578
156MP0004484_altered_response_of0.67672086
157MP0001293_anophthalmia0.67589275
158MP0000759_abnormal_skeletal_muscle0.67391631
159MP0008961_abnormal_basal_metabolism0.64840570
160MP0002089_abnormal_postnatal_growth/wei0.62646864
161MP0004085_abnormal_heartbeat0.59362073
162MP0001177_atelectasis0.58413508
163MP0004742_abnormal_vestibular_system0.57378440
164MP0005379_endocrine/exocrine_gland_phen0.57088068
165MP0002069_abnormal_eating/drinking_beha0.56957885
166MP0004142_abnormal_muscle_tone0.54926754
167MP0002295_abnormal_pulmonary_circulatio0.54639875
168MP0004087_abnormal_muscle_fiber0.54614342
169MP0005535_abnormal_body_temperature0.54397653
170MP0005257_abnormal_intraocular_pressure0.53701338

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.30673276
2Myokymia (HP:0002411)4.14248855
3Focal seizures (HP:0007359)3.95635498
4Cerebral inclusion bodies (HP:0100314)3.84215390
5Abnormal auditory evoked potentials (HP:0006958)3.82926044
6Cortical dysplasia (HP:0002539)3.80016050
7Visual hallucinations (HP:0002367)3.75097610
8Supranuclear gaze palsy (HP:0000605)3.75094777
9Focal motor seizures (HP:0011153)3.73507590
10Action tremor (HP:0002345)3.70326891
11Neurofibrillary tangles (HP:0002185)3.65263652
12Scanning speech (HP:0002168)3.59605979
13Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.35754023
14Atonic seizures (HP:0010819)2.92822766
15Ankyloglossia (HP:0010296)2.90033796
16Termporal pattern (HP:0011008)2.88023639
17Insidious onset (HP:0003587)2.88023639
18Ankle clonus (HP:0011448)2.85178546
19Mutism (HP:0002300)2.83995028
20Progressive cerebellar ataxia (HP:0002073)2.79959631
21Premature rupture of membranes (HP:0001788)2.79704116
22Absence seizures (HP:0002121)2.75718056
23Thyroid carcinoma (HP:0002890)2.67170836
24Cerebral aneurysm (HP:0004944)2.66046883
25Volvulus (HP:0002580)2.65970789
26Generalized tonic-clonic seizures (HP:0002069)2.65422060
27Epileptic encephalopathy (HP:0200134)2.62904251
28Exercise-induced muscle cramps (HP:0003710)2.61867528
29Abnormality of the lower motor neuron (HP:0002366)2.60468916
30Truncal ataxia (HP:0002078)2.57799348
31Urinary bladder sphincter dysfunction (HP:0002839)2.57274519
32Dialeptic seizures (HP:0011146)2.54769816
33Postural instability (HP:0002172)2.49177203
34Hypoplasia of the iris (HP:0007676)2.46981434
35Lower limb amyotrophy (HP:0007210)2.45655360
36Increased cerebral lipofuscin (HP:0011813)2.45185203
37Relative macrocephaly (HP:0004482)2.42392372
38Depression (HP:0000716)2.39122710
39Medulloblastoma (HP:0002885)2.38916976
40Apathy (HP:0000741)2.35727686
41Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.35237815
42Dysmetric saccades (HP:0000641)2.34108827
43Disinhibition (HP:0000734)2.26922369
44Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.26912873
45Wormian bones (HP:0002645)2.26824272
46Inappropriate behavior (HP:0000719)2.26263086
47Absent frontal sinuses (HP:0002688)2.26046772
48Syringomyelia (HP:0003396)2.25966455
49Spinal cord lesions (HP:0100561)2.25966455
50Dysdiadochokinesis (HP:0002075)2.25816058
51Abnormality of the epiphyses of the hand (HP:0005924)2.25176405
52Decreased lacrimation (HP:0000633)2.23359518
53Large earlobe (HP:0009748)2.23221850
54Resting tremor (HP:0002322)2.22058801
55Febrile seizures (HP:0002373)2.20904703
56Neuronal loss in central nervous system (HP:0002529)2.20067378
57Abnormality of binocular vision (HP:0011514)2.18879830
58Diplopia (HP:0000651)2.18879830
59Global brain atrophy (HP:0002283)2.17753870
60Rapidly progressive (HP:0003678)2.17264064
61Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.15564889
62Urinary urgency (HP:0000012)2.14910775
63Distal upper limb amyotrophy (HP:0007149)2.10522782
64Upper limb amyotrophy (HP:0009129)2.10522782
65Diminished motivation (HP:0000745)2.08800461
66Papilledema (HP:0001085)2.08534759
67Genetic anticipation (HP:0003743)2.08394563
68Tubulointerstitial nephritis (HP:0001970)2.07671597
69Abnormality of glycolipid metabolism (HP:0010969)2.07347437
70Abnormality of liposaccharide metabolism (HP:0010968)2.07347437
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.07347437
72Autoamputation (HP:0001218)2.06611750
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.06302337
74Osteolytic defects of the hand bones (HP:0009699)2.06302337
75Insomnia (HP:0100785)2.06028165
76Arterial tortuosity (HP:0005116)2.05059413
77Torticollis (HP:0000473)2.04006306
78Aortic dissection (HP:0002647)2.03909239
79Abnormality of oral frenula (HP:0000190)2.03518279
80Macroorchidism (HP:0000053)2.02094734
81Myocardial infarction (HP:0001658)2.01038578
82Impaired smooth pursuit (HP:0007772)2.00987512
83Pheochromocytoma (HP:0002666)2.00434145
84Freckling (HP:0001480)1.99820420
85Dysmetria (HP:0001310)1.99306182
86Blue irides (HP:0000635)1.98377859
87Bifid tongue (HP:0010297)1.97747935
88Ankle contracture (HP:0006466)1.96532127
89Truncal obesity (HP:0001956)1.95611900
90Impaired vibration sensation in the lower limbs (HP:0002166)1.95225865
91Abnormality of the ischium (HP:0003174)1.94839106
92Abnormality of the hip-girdle musculature (HP:0001445)1.94540889
93Abnormality of the musculature of the pelvis (HP:0001469)1.94540889
94Spastic gait (HP:0002064)1.94279613
95Deep philtrum (HP:0002002)1.91112562
96Drooling (HP:0002307)1.90544980
97Excessive salivation (HP:0003781)1.90544980
98Amblyopia (HP:0000646)1.90292934
99Lower limb muscle weakness (HP:0007340)1.89609983
100Distal lower limb amyotrophy (HP:0008944)1.88361756
101Degeneration of the lateral corticospinal tracts (HP:0002314)1.87665858
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.87665858
103Decreased motor nerve conduction velocity (HP:0003431)1.87565974
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87542022
105Peripheral hypomyelination (HP:0007182)1.87400321
106Heterotopia (HP:0002282)1.86639701
107Hemiparesis (HP:0001269)1.86554912
108Hammertoe (HP:0001765)1.86484541
109Embryonal renal neoplasm (HP:0011794)1.84916823
110Bradykinesia (HP:0002067)1.84827868
111Poor eye contact (HP:0000817)1.83946524
112J-shaped sella turcica (HP:0002680)1.83813398
113Vascular tortuosity (HP:0004948)1.83656194
114Spastic paraplegia (HP:0001258)1.83609573
115Atrophic scars (HP:0001075)1.83427718
116Hemiplegia (HP:0002301)1.83213413
117Increased nuchal translucency (HP:0010880)1.82854616
118Gaze-evoked nystagmus (HP:0000640)1.82683371
119Hyperacusis (HP:0010780)1.82324858
120Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82170404
121Anxiety (HP:0000739)1.80337379
122Pointed chin (HP:0000307)1.80200500
123Abnormality of ocular smooth pursuit (HP:0000617)1.79974490
124Protrusio acetabuli (HP:0003179)1.79933797
125Short middle phalanx of the 5th finger (HP:0004220)1.79918166
126Abnormal social behavior (HP:0012433)1.79655558
127Impaired social interactions (HP:0000735)1.79655558
128Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.79368718
129Neoplasm of the heart (HP:0100544)1.78796597
130Pulmonic stenosis (HP:0001642)1.78769663
131Achilles tendon contracture (HP:0001771)1.78356534
132Cystic hygroma (HP:0000476)1.78263311
133Anosmia (HP:0000458)1.77686208
134Nemaline bodies (HP:0003798)1.77195202
135Patchy hypopigmentation of hair (HP:0011365)1.77025968
136Increased variability in muscle fiber diameter (HP:0003557)1.77007113
137Systemic lupus erythematosus (HP:0002725)1.76974607
138Postural tremor (HP:0002174)1.76750306
139Broad ribs (HP:0000885)1.76501564
140Abnormality of the corticospinal tract (HP:0002492)1.76359786
141Aortic aneurysm (HP:0004942)1.75345345
142Decreased skull ossification (HP:0004331)1.74832668
143Failure to thrive in infancy (HP:0001531)1.74744017
144Dysostosis multiplex (HP:0000943)1.74007222
145Overgrowth (HP:0001548)1.73881311
146Striae distensae (HP:0001065)1.73811263
147Dementia (HP:0000726)1.73562760
148Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.73383123
149Increased neuronal autofluorescent lipopigment (HP:0002074)1.73319774
150Shallow orbits (HP:0000586)1.72931051
151Intention tremor (HP:0002080)1.72904267
152Split foot (HP:0001839)1.72581174
153Sensorimotor neuropathy (HP:0007141)1.72186554
154Spondylolisthesis (HP:0003302)1.71249911
155Axonal loss (HP:0003447)1.70834886
156Nephroblastoma (Wilms tumor) (HP:0002667)1.70637257
157Hand muscle atrophy (HP:0009130)1.69658044
158Bladder diverticulum (HP:0000015)1.68970121
159Pelvic girdle muscle weakness (HP:0003749)1.67871446
160Abnormality of the left ventricular outflow tract (HP:0011103)1.67378833
161Subaortic stenosis (HP:0001682)1.67378833
162Upper limb muscle weakness (HP:0003484)1.66956144
163Bilateral sensorineural hearing impairment (HP:0008619)1.66854817
164Turricephaly (HP:0000262)1.66555374
165Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65934686
166Subacute progressive viral hepatitis (HP:0006572)1.65807949
167Difficulty running (HP:0009046)1.65228986
168Loss of speech (HP:0002371)1.64930410
169Bowel diverticulosis (HP:0005222)1.64927811
170Focal dystonia (HP:0004373)1.64401880
171Mitral valve prolapse (HP:0001634)1.63820495
172Craniofacial dystonia (HP:0012179)1.62978264
173Rigidity (HP:0002063)1.62649964
174Fatigue (HP:0012378)1.62593434
175White forelock (HP:0002211)1.61668110
176Muscle fiber inclusion bodies (HP:0100299)1.61544086
177Abnormality of skull ossification (HP:0002703)1.59923478
178Pectus carinatum (HP:0000768)1.58660042
179Generalized hypopigmentation of hair (HP:0011358)1.56159760
180Acute myeloid leukemia (HP:0004808)1.55636092
181Soft skin (HP:0000977)1.55131271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.32453558
2PBK3.67946760
3EPHA43.37489988
4MARK12.90893704
5DAPK22.87201314
6PDK22.78973625
7BRD42.78193463
8NTRK32.66634192
9MAP3K42.51076961
10BMPR22.45608583
11BCR2.40868802
12PAK62.32364941
13NTRK12.29247373
14RIPK42.19720169
15KSR22.14579916
16MINK12.13449175
17NEK92.08906128
18LMTK22.03211668
19TRIM282.00612400
20PHKG11.83318701
21PHKG21.83318701
22TRIB31.78519571
23CAMKK11.78119512
24SIK21.76308160
25MAP2K41.70068681
26RIPK11.68968127
27AKT31.68108196
28NEK61.67357104
29NEK11.66402316
30EIF2AK11.64370387
31MAP3K61.62329250
32STK38L1.59729304
33NTRK21.59444100
34SCYL21.56481953
35KSR11.46324736
36RET1.43636619
37CDK121.42084992
38WEE11.38579202
39MAP2K71.36119394
40SRPK11.35671953
41CDK51.34693804
42TTN1.33054592
43TAOK21.32463171
44TTK1.28850551
45DAPK11.25938577
46PLK21.25023525
47MAP3K131.22256791
48GRK51.21239575
49FGR1.20833478
50PKN21.19346920
51MKNK11.18496944
52MAP3K21.17721613
53MAP3K121.16310356
54EIF2AK31.15072522
55DDR21.10509858
56PTK2B1.09381220
57BMX1.09038563
58ERBB41.08595913
59CAMKK21.08555666
60EPHA31.05491159
61CSNK1A1L1.05388011
62CAMK1G1.04623333
63LATS21.03759036
64TYRO31.00684260
65LATS11.00168681
66PAK30.98699788
67TSSK60.98514199
68CDK60.98092644
69PRKD30.94622107
70PIK3CG0.93703536
71STK380.93276584
72CAMK1D0.91103839
73ALK0.89019416
74GRK70.88087442
75ARAF0.87502972
76PRPF4B0.86080042
77RAF10.84498306
78ICK0.84181997
79IRAK30.84108894
80DAPK30.84070360
81OBSCN0.84007439
82PLK40.83567381
83PTK60.83460232
84MAP3K50.81271132
85PLK30.80506255
86STK110.79977126
87TGFBR20.76425901
88PDPK10.75842202
89ACVR1B0.75827850
90PDGFRA0.73512955
91PRKCG0.72179971
92PDK10.71559594
93UHMK10.71106977
94CDK190.70965117
95TNIK0.70298088
96MOS0.70095597
97MAP3K140.69484376
98RPS6KA20.69373299
99CSNK1G20.68998385
100BRSK20.68561090
101ERBB30.68202757
102EIF2AK20.67845795
103CDK140.67369883
104CASK0.67327866
105CDK150.66432349
106CDK180.65052938
107DYRK30.64680185
108STK30.64672151
109CAMK2A0.62461105
110PRKCH0.61557694
111MELK0.61262676
112PKN10.60442314
113TAOK10.60090175
114PRKCZ0.58869994
115JAK20.58347284
116FLT30.58239655
117FES0.57918095
118PNCK0.56799805
119MAP2K10.56576758
120MAP3K70.56085628
121FER0.55191270
122YES10.54646200
123MAP3K100.53522882
124CLK10.53144566
125FYN0.52545356
126MST40.52236328
127CSNK1G30.52012246
128PTK20.51339133
129MAP3K10.50467629
130PDGFRB0.50171605
131CDK11A0.49293154
132FGFR20.48856718
133SGK10.48708204
134MAPK100.48596149
135CAMK2B0.48352454
136FGFR10.48338696
137PAK20.47973236
138MET0.47498601
139SGK30.46773962
140JAK10.46374762
141SGK4940.45218584
142SGK2230.45218584
143RPS6KA30.44748472
144CAMK2D0.44552530
145PRKCE0.44332224
146PRKG20.43330200
147TBK10.42110681
148ROCK20.41398196
149WNK10.41342631
150CSNK1G10.40427709
151MARK20.39719598
152MAPK130.39621349
153PLK10.39518629
154ATM0.38770488
155MAPK150.38537915
156DMPK0.37611254
157MTOR0.37268298
158EGFR0.37077917
159DYRK1A0.36080243
160PRKACB0.33612393

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.83948938
2Olfactory transduction_Homo sapiens_hsa047402.82640396
3Nicotine addiction_Homo sapiens_hsa050331.98836398
4Nitrogen metabolism_Homo sapiens_hsa009101.88938220
5Circadian entrainment_Homo sapiens_hsa047131.84909691
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84214877
7GABAergic synapse_Homo sapiens_hsa047271.78210542
8Long-term potentiation_Homo sapiens_hsa047201.72798176
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72519610
10Adherens junction_Homo sapiens_hsa045201.71064083
11Dopaminergic synapse_Homo sapiens_hsa047281.67396115
12Circadian rhythm_Homo sapiens_hsa047101.66199296
13Morphine addiction_Homo sapiens_hsa050321.66164255
14Glutamatergic synapse_Homo sapiens_hsa047241.64653440
15Salivary secretion_Homo sapiens_hsa049701.59681760
16Amphetamine addiction_Homo sapiens_hsa050311.57165397
17Cholinergic synapse_Homo sapiens_hsa047251.55977707
18Insulin secretion_Homo sapiens_hsa049111.52697350
19Renin secretion_Homo sapiens_hsa049241.51506502
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47796743
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47297324
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46511887
23Gastric acid secretion_Homo sapiens_hsa049711.42425935
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39423291
25Type II diabetes mellitus_Homo sapiens_hsa049301.37749765
26Oxytocin signaling pathway_Homo sapiens_hsa049211.37082324
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35826913
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35493919
29TGF-beta signaling pathway_Homo sapiens_hsa043501.35093044
30GnRH signaling pathway_Homo sapiens_hsa049121.33204606
31Propanoate metabolism_Homo sapiens_hsa006401.32439346
32ECM-receptor interaction_Homo sapiens_hsa045121.31433365
33Cell cycle_Homo sapiens_hsa041101.31383256
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30939079
35Collecting duct acid secretion_Homo sapiens_hsa049661.30828004
36Steroid biosynthesis_Homo sapiens_hsa001001.28297245
37Cocaine addiction_Homo sapiens_hsa050301.28037645
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28010609
39MicroRNAs in cancer_Homo sapiens_hsa052061.25767030
40Glioma_Homo sapiens_hsa052141.22361515
41Gap junction_Homo sapiens_hsa045401.22356248
42Shigellosis_Homo sapiens_hsa051311.20236087
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.19612582
44Estrogen signaling pathway_Homo sapiens_hsa049151.18293769
45Phototransduction_Homo sapiens_hsa047441.17728917
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17217038
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14729720
48Small cell lung cancer_Homo sapiens_hsa052221.12793313
49Pancreatic cancer_Homo sapiens_hsa052121.11654445
50Calcium signaling pathway_Homo sapiens_hsa040201.11098162
51Vibrio cholerae infection_Homo sapiens_hsa051101.10847994
52Taste transduction_Homo sapiens_hsa047421.08303676
53Long-term depression_Homo sapiens_hsa047301.06691155
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05888935
55Hepatitis B_Homo sapiens_hsa051611.05579118
56cAMP signaling pathway_Homo sapiens_hsa040241.05467568
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.03710010
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02525486
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02110775
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01145521
61mTOR signaling pathway_Homo sapiens_hsa041501.00169044
62ErbB signaling pathway_Homo sapiens_hsa040120.99275488
63Dilated cardiomyopathy_Homo sapiens_hsa054140.98954780
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98652095
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97049683
66Legionellosis_Homo sapiens_hsa051340.96599454
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95785466
68Thyroid cancer_Homo sapiens_hsa052160.95185437
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94688856
70Serotonergic synapse_Homo sapiens_hsa047260.93973747
71Dorso-ventral axis formation_Homo sapiens_hsa043200.92573212
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92550288
73Prolactin signaling pathway_Homo sapiens_hsa049170.91625142
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91088533
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90160601
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89757752
77Other glycan degradation_Homo sapiens_hsa005110.87943209
78Axon guidance_Homo sapiens_hsa043600.86359585
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.82110212
80Lysosome_Homo sapiens_hsa041420.81656778
81mRNA surveillance pathway_Homo sapiens_hsa030150.80229612
82MAPK signaling pathway_Homo sapiens_hsa040100.80096430
83TNF signaling pathway_Homo sapiens_hsa046680.79632010
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79401654
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78598289
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78489448
87Melanogenesis_Homo sapiens_hsa049160.78393192
88Renal cell carcinoma_Homo sapiens_hsa052110.76649592
89RNA transport_Homo sapiens_hsa030130.75929098
90Fatty acid metabolism_Homo sapiens_hsa012120.75776383
91Phagosome_Homo sapiens_hsa041450.75130889
92Prion diseases_Homo sapiens_hsa050200.74509357
93HIF-1 signaling pathway_Homo sapiens_hsa040660.73920890
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73561506
95Viral carcinogenesis_Homo sapiens_hsa052030.72436828
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72270188
97VEGF signaling pathway_Homo sapiens_hsa043700.72114106
98Endocytosis_Homo sapiens_hsa041440.72061480
99Fatty acid biosynthesis_Homo sapiens_hsa000610.71929862
100Hippo signaling pathway_Homo sapiens_hsa043900.70894456
101Basal transcription factors_Homo sapiens_hsa030220.70188658
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70034212
103Tight junction_Homo sapiens_hsa045300.68885967
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67737768
105Insulin signaling pathway_Homo sapiens_hsa049100.66319295
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65499454
107Prostate cancer_Homo sapiens_hsa052150.65388944
108Pertussis_Homo sapiens_hsa051330.64484880
109Sphingolipid metabolism_Homo sapiens_hsa006000.64189391
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.64049473
111Osteoclast differentiation_Homo sapiens_hsa043800.63438784
112Rap1 signaling pathway_Homo sapiens_hsa040150.63413848
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.63317346
114Tuberculosis_Homo sapiens_hsa051520.63268015
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63254011
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.62617207
117Chemokine signaling pathway_Homo sapiens_hsa040620.62354453
118Salmonella infection_Homo sapiens_hsa051320.62185266
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61620561
120Amoebiasis_Homo sapiens_hsa051460.61328753
121Non-homologous end-joining_Homo sapiens_hsa034500.61181111
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60147348
123Pancreatic secretion_Homo sapiens_hsa049720.60086253
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59932155
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59042939
126Rheumatoid arthritis_Homo sapiens_hsa053230.58759421
127Non-small cell lung cancer_Homo sapiens_hsa052230.58736405
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58329499
129Protein export_Homo sapiens_hsa030600.57598246
130Glucagon signaling pathway_Homo sapiens_hsa049220.57030573
131Pathways in cancer_Homo sapiens_hsa052000.56048128
132Proteoglycans in cancer_Homo sapiens_hsa052050.55891672
133FoxO signaling pathway_Homo sapiens_hsa040680.55729082
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55669557
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55465056
136Chronic myeloid leukemia_Homo sapiens_hsa052200.55318895
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55309726
138Colorectal cancer_Homo sapiens_hsa052100.54571800
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54257846
140Endometrial cancer_Homo sapiens_hsa052130.53367742
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52434739
142Focal adhesion_Homo sapiens_hsa045100.52293841
143B cell receptor signaling pathway_Homo sapiens_hsa046620.52190476
144Insulin resistance_Homo sapiens_hsa049310.51753399
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.51528387
146Platelet activation_Homo sapiens_hsa046110.50760413
147Bile secretion_Homo sapiens_hsa049760.50163646
148Inositol phosphate metabolism_Homo sapiens_hsa005620.49734128
149Thyroid hormone synthesis_Homo sapiens_hsa049180.49655067
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49204380
151Oocyte meiosis_Homo sapiens_hsa041140.48913195

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