

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.85030849 |
| 2 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.70650015 |
| 3 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.69934207 |
| 4 | vocalization behavior (GO:0071625) | 5.66813853 |
| 5 | synaptic vesicle exocytosis (GO:0016079) | 5.66578290 |
| 6 | synaptic vesicle maturation (GO:0016188) | 5.64124483 |
| 7 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.51567737 |
| 8 | protein localization to synapse (GO:0035418) | 5.25652767 |
| 9 | neuron cell-cell adhesion (GO:0007158) | 5.22202773 |
| 10 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.12923440 |
| 11 | locomotory exploration behavior (GO:0035641) | 4.96276143 |
| 12 | glutamate secretion (GO:0014047) | 4.95531942 |
| 13 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.87991514 |
| 14 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.82105557 |
| 15 | behavioral response to nicotine (GO:0035095) | 4.79968502 |
| 16 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.51765169 |
| 17 | neuronal action potential propagation (GO:0019227) | 4.39676524 |
| 18 | synaptic transmission, glutamatergic (GO:0035249) | 4.39597584 |
| 19 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.39287655 |
| 20 | neurotransmitter secretion (GO:0007269) | 4.39165553 |
| 21 | glutamate receptor signaling pathway (GO:0007215) | 4.39125832 |
| 22 | positive regulation of synapse maturation (GO:0090129) | 4.36298508 |
| 23 | regulation of synaptic vesicle transport (GO:1902803) | 4.34353830 |
| 24 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.32436237 |
| 25 | exploration behavior (GO:0035640) | 4.24606424 |
| 26 | neuron-neuron synaptic transmission (GO:0007270) | 4.23724139 |
| 27 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.20156347 |
| 28 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.19432558 |
| 29 | dendritic spine morphogenesis (GO:0060997) | 4.07414659 |
| 30 | layer formation in cerebral cortex (GO:0021819) | 3.97481712 |
| 31 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.97285142 |
| 32 | positive regulation of membrane potential (GO:0045838) | 3.89040290 |
| 33 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.88214096 |
| 34 | proline transport (GO:0015824) | 3.84618191 |
| 35 | long-term memory (GO:0007616) | 3.84031184 |
| 36 | neuron recognition (GO:0008038) | 3.83555235 |
| 37 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.78832166 |
| 38 | synaptic vesicle endocytosis (GO:0048488) | 3.77417748 |
| 39 | regulation of synapse structural plasticity (GO:0051823) | 3.76004461 |
| 40 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.75577478 |
| 41 | regulation of postsynaptic membrane potential (GO:0060078) | 3.74900809 |
| 42 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.69444672 |
| 43 | neurotransmitter transport (GO:0006836) | 3.66450231 |
| 44 | transmission of nerve impulse (GO:0019226) | 3.63658625 |
| 45 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.63016823 |
| 46 | postsynaptic membrane organization (GO:0001941) | 3.62360703 |
| 47 | nucleobase catabolic process (GO:0046113) | 3.62249321 |
| 48 | neuromuscular process controlling posture (GO:0050884) | 3.62030336 |
| 49 | presynaptic membrane assembly (GO:0097105) | 3.56595489 |
| 50 | cell migration in hindbrain (GO:0021535) | 3.51910081 |
| 51 | regulation of synaptic plasticity (GO:0048167) | 3.51244598 |
| 52 | gamma-aminobutyric acid transport (GO:0015812) | 3.50624741 |
| 53 | neuromuscular synaptic transmission (GO:0007274) | 3.47956360 |
| 54 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.47472752 |
| 55 | response to histamine (GO:0034776) | 3.46300334 |
| 56 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.44263705 |
| 57 | long-term synaptic potentiation (GO:0060291) | 3.40635582 |
| 58 | regulation of vesicle fusion (GO:0031338) | 3.39939943 |
| 59 | regulation of synapse maturation (GO:0090128) | 3.39418903 |
| 60 | presynaptic membrane organization (GO:0097090) | 3.35791692 |
| 61 | neuromuscular process controlling balance (GO:0050885) | 3.35219055 |
| 62 | regulation of neurotransmitter levels (GO:0001505) | 3.35171633 |
| 63 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.34938622 |
| 64 | axonal fasciculation (GO:0007413) | 3.34261784 |
| 65 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.33486014 |
| 66 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.33203910 |
| 67 | cellular potassium ion homeostasis (GO:0030007) | 3.32595252 |
| 68 | negative regulation of microtubule polymerization (GO:0031115) | 3.32196366 |
| 69 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.32149926 |
| 70 | regulation of neurotransmitter secretion (GO:0046928) | 3.30317422 |
| 71 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.28143679 |
| 72 | behavioral defense response (GO:0002209) | 3.27952689 |
| 73 | behavioral fear response (GO:0001662) | 3.27952689 |
| 74 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.24656486 |
| 75 | positive regulation of dendritic spine development (GO:0060999) | 3.24430864 |
| 76 | startle response (GO:0001964) | 3.21871857 |
| 77 | membrane depolarization (GO:0051899) | 3.20344482 |
| 78 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.19631795 |
| 79 | positive regulation of neurotransmitter transport (GO:0051590) | 3.17638009 |
| 80 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.17451794 |
| 81 | regulation of glutamate secretion (GO:0014048) | 3.15817363 |
| 82 | membrane hyperpolarization (GO:0060081) | 3.13773096 |
| 83 | fear response (GO:0042596) | 3.12863595 |
| 84 | learning (GO:0007612) | 3.11571247 |
| 85 | auditory behavior (GO:0031223) | 3.09552197 |
| 86 | dendritic spine organization (GO:0097061) | 3.09076614 |
| 87 | regulation of dendritic spine development (GO:0060998) | 3.07966719 |
| 88 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.07546391 |
| 89 | detection of light stimulus involved in visual perception (GO:0050908) | 3.07326247 |
| 90 | detection of light stimulus involved in sensory perception (GO:0050962) | 3.07326247 |
| 91 | synapse assembly (GO:0007416) | 3.07271049 |
| 92 | synaptic transmission (GO:0007268) | 3.06624036 |
| 93 | mating behavior (GO:0007617) | 3.06477482 |
| 94 | regulation of respiratory system process (GO:0044065) | 3.05625764 |
| 95 | innervation (GO:0060384) | 3.05038595 |
| 96 | regulation of neurotransmitter transport (GO:0051588) | 3.04720474 |
| 97 | membrane depolarization during action potential (GO:0086010) | 3.04111394 |
| 98 | neuromuscular process (GO:0050905) | 3.02500262 |
| 99 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.00920809 |
| 100 | activation of protein kinase A activity (GO:0034199) | 2.99380688 |
| 101 | mechanosensory behavior (GO:0007638) | 2.99009992 |
| 102 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.96733030 |
| 103 | regulation of action potential (GO:0098900) | 2.96520125 |
| 104 | neuronal action potential (GO:0019228) | 2.95838410 |
| 105 | behavioral response to cocaine (GO:0048148) | 2.95188000 |
| 106 | regulation of synaptic transmission (GO:0050804) | 2.94750159 |
| 107 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.94563498 |
| 108 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.93826782 |
| 109 | establishment of mitochondrion localization (GO:0051654) | 2.93088889 |
| 110 | intraspecies interaction between organisms (GO:0051703) | 2.92604637 |
| 111 | social behavior (GO:0035176) | 2.92604637 |
| 112 | neuronal ion channel clustering (GO:0045161) | 2.91328770 |
| 113 | serotonin metabolic process (GO:0042428) | 2.89882706 |
| 114 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.89633325 |
| 115 | primary amino compound metabolic process (GO:1901160) | 2.84390125 |
| 116 | behavioral response to ethanol (GO:0048149) | 2.82436657 |
| 117 | righting reflex (GO:0060013) | 2.80159800 |
| 118 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.80081314 |
| 119 | tachykinin receptor signaling pathway (GO:0007217) | 2.78316325 |
| 120 | adult walking behavior (GO:0007628) | 2.78131052 |
| 121 | response to pheromone (GO:0019236) | 2.76960157 |
| 122 | reflex (GO:0060004) | 2.72534288 |
| 123 | protein localization to cilium (GO:0061512) | 2.72528249 |
| 124 | axon ensheathment in central nervous system (GO:0032291) | 2.70063981 |
| 125 | central nervous system myelination (GO:0022010) | 2.70063981 |
| 126 | dendrite morphogenesis (GO:0048813) | 2.68539145 |
| 127 | response to auditory stimulus (GO:0010996) | 2.66396321 |
| 128 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.63566701 |
| 129 | synaptic transmission, cholinergic (GO:0007271) | 2.62092355 |
| 130 | retinal cone cell development (GO:0046549) | 2.60041988 |
| 131 | synapse organization (GO:0050808) | 2.58633763 |
| 132 | central nervous system neuron axonogenesis (GO:0021955) | 2.57648142 |
| 133 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.57425299 |
| 134 | adult behavior (GO:0030534) | 2.56826911 |
| 135 | indolalkylamine metabolic process (GO:0006586) | 2.55001442 |
| 136 | calcium ion-dependent exocytosis (GO:0017156) | 2.53058238 |
| 137 | cochlea development (GO:0090102) | 2.52862068 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.65926119 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.44120639 |
| 3 | REST_21632747_ChIP-Seq_MESCs_Mouse | 3.21062697 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.19999633 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.10711325 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.93036126 |
| 7 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.89307111 |
| 8 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.70916232 |
| 9 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.69738341 |
| 10 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.69738341 |
| 11 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.69652869 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.58020921 |
| 13 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.50612570 |
| 14 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.48804927 |
| 15 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.43990968 |
| 16 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.43089781 |
| 17 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.42528457 |
| 18 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.41790441 |
| 19 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.38710365 |
| 20 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.32068929 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.27658442 |
| 22 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.23837609 |
| 23 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.22800440 |
| 24 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.17529287 |
| 25 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 2.17256168 |
| 26 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.16419054 |
| 27 | * EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.15720659 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.14779887 |
| 29 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.12336530 |
| 30 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.80257206 |
| 31 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.71367174 |
| 32 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.69730843 |
| 33 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.67964800 |
| 34 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.65941885 |
| 35 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.57810803 |
| 36 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.57552697 |
| 37 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.57200245 |
| 38 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.53046900 |
| 39 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.50648252 |
| 40 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.50648252 |
| 41 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.50238596 |
| 42 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.48598859 |
| 43 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.42866674 |
| 44 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.42177864 |
| 45 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.41212894 |
| 46 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.40343770 |
| 47 | EWS_26573619_Chip-Seq_HEK293_Human | 1.36434087 |
| 48 | * ER_23166858_ChIP-Seq_MCF-7_Human | 1.35403336 |
| 49 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.34269651 |
| 50 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.32766456 |
| 51 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.31012394 |
| 52 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.30560870 |
| 53 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.30375222 |
| 54 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.29799776 |
| 55 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.26896438 |
| 56 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.26408353 |
| 57 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.26274294 |
| 58 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.26274294 |
| 59 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.24226238 |
| 60 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.21798678 |
| 61 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.20075645 |
| 62 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.19563091 |
| 63 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.19442452 |
| 64 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.19309097 |
| 65 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.15557502 |
| 66 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.14977934 |
| 67 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.14595788 |
| 68 | P300_19829295_ChIP-Seq_ESCs_Human | 1.13054873 |
| 69 | AR_19668381_ChIP-Seq_PC3_Human | 1.12194290 |
| 70 | VDR_22108803_ChIP-Seq_LS180_Human | 1.12149122 |
| 71 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.12102637 |
| 72 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11594075 |
| 73 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.10675393 |
| 74 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.09446550 |
| 75 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.08319487 |
| 76 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.08144119 |
| 77 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.08027315 |
| 78 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.07955792 |
| 79 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.07085321 |
| 80 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.07018000 |
| 81 | KDM2B_26808549_Chip-Seq_K562_Human | 1.05516702 |
| 82 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.03326146 |
| 83 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.03311889 |
| 84 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.03287596 |
| 85 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.03039243 |
| 86 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.02417981 |
| 87 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.01535058 |
| 88 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.01429368 |
| 89 | FUS_26573619_Chip-Seq_HEK293_Human | 1.01108267 |
| 90 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.01052853 |
| 91 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.00509161 |
| 92 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.99303579 |
| 93 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.98745445 |
| 94 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.98270597 |
| 95 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.97089552 |
| 96 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.96735214 |
| 97 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.96666110 |
| 98 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.96501254 |
| 99 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.96450603 |
| 100 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.96359577 |
| 101 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.95294385 |
| 102 | AR_25329375_ChIP-Seq_VCAP_Human | 0.94230371 |
| 103 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.93291256 |
| 104 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.92053384 |
| 105 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.91195070 |
| 106 | TCF4_23295773_ChIP-Seq_U87_Human | 0.90644720 |
| 107 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.89792437 |
| 108 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89703674 |
| 109 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.89664849 |
| 110 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.89578394 |
| 111 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.89487744 |
| 112 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.89270881 |
| 113 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.88325966 |
| 114 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.87435096 |
| 115 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.86772990 |
| 116 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.86494439 |
| 117 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.85774673 |
| 118 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.85480831 |
| 119 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.84758551 |
| 120 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.83842020 |
| 121 | * STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.81763110 |
| 122 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.81328873 |
| 123 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.80714545 |
| 124 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.80483865 |
| 125 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.80349007 |
| 126 | JUN_21703547_ChIP-Seq_K562_Human | 0.79122533 |
| 127 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.78124557 |
| 128 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.78058592 |
| 129 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.77680588 |
| 130 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.77659062 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.85977499 |
| 2 | MP0003880_abnormal_central_pattern | 4.99782727 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.00153117 |
| 4 | MP0004270_analgesia | 3.69114392 |
| 5 | MP0009745_abnormal_behavioral_response | 3.32483671 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.25463318 |
| 7 | MP0009046_muscle_twitch | 3.07275862 |
| 8 | MP0002064_seizures | 3.07190852 |
| 9 | MP0001968_abnormal_touch/_nociception | 3.04996848 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.87168531 |
| 11 | MP0005423_abnormal_somatic_nervous | 2.68276667 |
| 12 | MP0002734_abnormal_mechanical_nocicepti | 2.63929469 |
| 13 | MP0002272_abnormal_nervous_system | 2.61718430 |
| 14 | MP0002822_catalepsy | 2.45843787 |
| 15 | MP0002736_abnormal_nociception_after | 2.40162697 |
| 16 | MP0001486_abnormal_startle_reflex | 2.39741791 |
| 17 | MP0002735_abnormal_chemical_nociception | 2.27893529 |
| 18 | MP0001501_abnormal_sleep_pattern | 2.21699170 |
| 19 | MP0002733_abnormal_thermal_nociception | 2.15160642 |
| 20 | MP0001440_abnormal_grooming_behavior | 2.14526016 |
| 21 | MP0002184_abnormal_innervation | 2.05449060 |
| 22 | MP0001970_abnormal_pain_threshold | 2.03712886 |
| 23 | MP0006276_abnormal_autonomic_nervous | 2.00413478 |
| 24 | MP0002067_abnormal_sensory_capabilities | 1.98669579 |
| 25 | MP0000778_abnormal_nervous_system | 1.90183348 |
| 26 | MP0004858_abnormal_nervous_system | 1.84679197 |
| 27 | MP0001529_abnormal_vocalization | 1.74801059 |
| 28 | MP0001986_abnormal_taste_sensitivity | 1.73315768 |
| 29 | MP0002557_abnormal_social/conspecific_i | 1.72502049 |
| 30 | MP0001984_abnormal_olfaction | 1.71203092 |
| 31 | MP0004924_abnormal_behavior | 1.70837693 |
| 32 | MP0005386_behavior/neurological_phenoty | 1.70837693 |
| 33 | MP0005645_abnormal_hypothalamus_physiol | 1.69179093 |
| 34 | MP0004811_abnormal_neuron_physiology | 1.66165881 |
| 35 | MP0003787_abnormal_imprinting | 1.64590486 |
| 36 | MP0004142_abnormal_muscle_tone | 1.64533747 |
| 37 | MP0002102_abnormal_ear_morphology | 1.63668958 |
| 38 | MP0000955_abnormal_spinal_cord | 1.62815716 |
| 39 | MP0002909_abnormal_adrenal_gland | 1.60478379 |
| 40 | MP0003329_amyloid_beta_deposits | 1.59583393 |
| 41 | MP0003122_maternal_imprinting | 1.54012901 |
| 42 | MP0008569_lethality_at_weaning | 1.53646448 |
| 43 | MP0001905_abnormal_dopamine_level | 1.46686070 |
| 44 | MP0002882_abnormal_neuron_morphology | 1.46395054 |
| 45 | MP0002066_abnormal_motor_capabilities/c | 1.43597646 |
| 46 | MP0003136_yellow_coat_color | 1.39082974 |
| 47 | MP0006292_abnormal_olfactory_placode | 1.36270430 |
| 48 | MP0009780_abnormal_chondrocyte_physiolo | 1.29947393 |
| 49 | MP0005646_abnormal_pituitary_gland | 1.27884428 |
| 50 | MP0003879_abnormal_hair_cell | 1.26451254 |
| 51 | MP0010386_abnormal_urinary_bladder | 1.26015198 |
| 52 | MP0000569_abnormal_digit_pigmentation | 1.23938449 |
| 53 | MP0004147_increased_porphyrin_level | 1.22727575 |
| 54 | MP0001502_abnormal_circadian_rhythm | 1.21117980 |
| 55 | MP0001188_hyperpigmentation | 1.18727153 |
| 56 | MP0004885_abnormal_endolymph | 1.16776872 |
| 57 | MP0003195_calcinosis | 1.16375948 |
| 58 | MP0004145_abnormal_muscle_electrophysio | 1.15358966 |
| 59 | MP0002152_abnormal_brain_morphology | 1.15261397 |
| 60 | MP0005253_abnormal_eye_physiology | 1.13724477 |
| 61 | MP0003646_muscle_fatigue | 1.10878901 |
| 62 | MP0005499_abnormal_olfactory_system | 1.10750606 |
| 63 | MP0005394_taste/olfaction_phenotype | 1.10750606 |
| 64 | MP0004043_abnormal_pH_regulation | 1.10145705 |
| 65 | MP0003633_abnormal_nervous_system | 1.08675661 |
| 66 | MP0008872_abnormal_physiological_respon | 1.07090202 |
| 67 | MP0000751_myopathy | 1.05939852 |
| 68 | MP0002837_dystrophic_cardiac_calcinosis | 1.03654926 |
| 69 | MP0005551_abnormal_eye_electrophysiolog | 1.00097500 |
| 70 | MP0002876_abnormal_thyroid_physiology | 0.99879584 |
| 71 | MP0006072_abnormal_retinal_apoptosis | 0.99835708 |
| 72 | MP0002928_abnormal_bile_duct | 0.99575665 |
| 73 | MP0002229_neurodegeneration | 0.98266981 |
| 74 | MP0002653_abnormal_ependyma_morphology | 0.95068866 |
| 75 | MP0003631_nervous_system_phenotype | 0.94543573 |
| 76 | MP0002752_abnormal_somatic_nervous | 0.93659359 |
| 77 | MP0000631_abnormal_neuroendocrine_gland | 0.90646395 |
| 78 | MP0004133_heterotaxia | 0.90375025 |
| 79 | MP0002069_abnormal_eating/drinking_beha | 0.89434383 |
| 80 | MP0004742_abnormal_vestibular_system | 0.89349046 |
| 81 | MP0004233_abnormal_muscle_weight | 0.88396104 |
| 82 | MP0002638_abnormal_pupillary_reflex | 0.87066314 |
| 83 | MP0000013_abnormal_adipose_tissue | 0.85665306 |
| 84 | MP0003137_abnormal_impulse_conducting | 0.85178564 |
| 85 | MP0003283_abnormal_digestive_organ | 0.83676622 |
| 86 | MP0004085_abnormal_heartbeat | 0.82967271 |
| 87 | MP0005174_abnormal_tail_pigmentation | 0.82073691 |
| 88 | MP0005171_absent_coat_pigmentation | 0.82021453 |
| 89 | MP0001963_abnormal_hearing_physiology | 0.81886537 |
| 90 | MP0008874_decreased_physiological_sensi | 0.81173835 |
| 91 | MP0008995_early_reproductive_senescence | 0.79678364 |
| 92 | MP0004130_abnormal_muscle_cell | 0.78179772 |
| 93 | MP0003634_abnormal_glial_cell | 0.78082094 |
| 94 | MP0003123_paternal_imprinting | 0.78007840 |
| 95 | MP0003878_abnormal_ear_physiology | 0.77991594 |
| 96 | MP0005377_hearing/vestibular/ear_phenot | 0.77991594 |
| 97 | MP0000372_irregular_coat_pigmentation | 0.76004944 |
| 98 | MP0005195_abnormal_posterior_eye | 0.74889460 |
| 99 | MP0003698_abnormal_male_reproductive | 0.74878646 |
| 100 | MP0003861_abnormal_nervous_system | 0.74457209 |
| 101 | MP0003121_genomic_imprinting | 0.73261401 |
| 102 | MP0003119_abnormal_digestive_system | 0.71163528 |
| 103 | MP0008877_abnormal_DNA_methylation | 0.71026535 |
| 104 | MP0002234_abnormal_pharynx_morphology | 0.70482018 |
| 105 | MP0002751_abnormal_autonomic_nervous | 0.70359753 |
| 106 | MP0002160_abnormal_reproductive_system | 0.69774209 |
| 107 | MP0004215_abnormal_myocardial_fiber | 0.68809369 |
| 108 | MP0003632_abnormal_nervous_system | 0.68581323 |
| 109 | MP0001485_abnormal_pinna_reflex | 0.67646231 |
| 110 | MP0005535_abnormal_body_temperature | 0.65195763 |
| 111 | MP0000427_abnormal_hair_cycle | 0.64523909 |
| 112 | MP0005409_darkened_coat_color | 0.64367434 |
| 113 | MP0003890_abnormal_embryonic-extraembry | 0.61662925 |
| 114 | MP0001664_abnormal_digestion | 0.61106656 |
| 115 | MP0002332_abnormal_exercise_endurance | 0.60756061 |
| 116 | MP0010769_abnormal_survival | 0.60658051 |
| 117 | MP0010768_mortality/aging | 0.58379733 |
| 118 | MP0001943_abnormal_respiration | 0.58370483 |
| 119 | MP0010770_preweaning_lethality | 0.58105526 |
| 120 | MP0002082_postnatal_lethality | 0.58105526 |
| 121 | MP0006035_abnormal_mitochondrial_morpho | 0.58058752 |
| 122 | MP0000026_abnormal_inner_ear | 0.55612565 |
| 123 | MP0000920_abnormal_myelination | 0.54283361 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.96098779 |
| 2 | Myokymia (HP:0002411) | 6.59729829 |
| 3 | Focal seizures (HP:0007359) | 5.49624538 |
| 4 | Visual hallucinations (HP:0002367) | 5.29411263 |
| 5 | Epileptic encephalopathy (HP:0200134) | 5.04986990 |
| 6 | Atonic seizures (HP:0010819) | 4.95794237 |
| 7 | Febrile seizures (HP:0002373) | 4.75731287 |
| 8 | Absence seizures (HP:0002121) | 4.44639646 |
| 9 | Dialeptic seizures (HP:0011146) | 4.13601723 |
| 10 | Progressive cerebellar ataxia (HP:0002073) | 3.90563350 |
| 11 | Generalized tonic-clonic seizures (HP:0002069) | 3.87827548 |
| 12 | Hyperventilation (HP:0002883) | 3.51138234 |
| 13 | Congenital stationary night blindness (HP:0007642) | 3.44585257 |
| 14 | Broad-based gait (HP:0002136) | 3.41555416 |
| 15 | Amblyopia (HP:0000646) | 3.39858028 |
| 16 | Abnormality of the lower motor neuron (HP:0002366) | 3.21624825 |
| 17 | Supranuclear gaze palsy (HP:0000605) | 3.20864003 |
| 18 | Type II lissencephaly (HP:0007260) | 3.12944177 |
| 19 | Nephronophthisis (HP:0000090) | 3.12680620 |
| 20 | Action tremor (HP:0002345) | 3.10305730 |
| 21 | Dysdiadochokinesis (HP:0002075) | 3.05375535 |
| 22 | Abnormality of midbrain morphology (HP:0002418) | 3.03985425 |
| 23 | Molar tooth sign on MRI (HP:0002419) | 3.03985425 |
| 24 | Poor eye contact (HP:0000817) | 3.01375743 |
| 25 | Pancreatic cysts (HP:0001737) | 2.99809882 |
| 26 | Dysmetria (HP:0001310) | 2.87326004 |
| 27 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.86024577 |
| 28 | Anxiety (HP:0000739) | 2.85690373 |
| 29 | Gaze-evoked nystagmus (HP:0000640) | 2.85265341 |
| 30 | Hemiparesis (HP:0001269) | 2.85192233 |
| 31 | Pancreatic fibrosis (HP:0100732) | 2.81605580 |
| 32 | Depression (HP:0000716) | 2.79014210 |
| 33 | Ankle clonus (HP:0011448) | 2.78230693 |
| 34 | Cerebellar dysplasia (HP:0007033) | 2.74849198 |
| 35 | Drooling (HP:0002307) | 2.69952985 |
| 36 | Excessive salivation (HP:0003781) | 2.69952985 |
| 37 | Impaired social interactions (HP:0000735) | 2.66574972 |
| 38 | Abnormal social behavior (HP:0012433) | 2.66574972 |
| 39 | True hermaphroditism (HP:0010459) | 2.66274328 |
| 40 | Limb dystonia (HP:0002451) | 2.61779493 |
| 41 | Amyotrophic lateral sclerosis (HP:0007354) | 2.60728754 |
| 42 | Attenuation of retinal blood vessels (HP:0007843) | 2.55893367 |
| 43 | Truncal ataxia (HP:0002078) | 2.55683771 |
| 44 | Lissencephaly (HP:0001339) | 2.55462170 |
| 45 | Mutism (HP:0002300) | 2.55200855 |
| 46 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.54887854 |
| 47 | Cerebral inclusion bodies (HP:0100314) | 2.53448590 |
| 48 | Abnormality of the renal medulla (HP:0100957) | 2.50242856 |
| 49 | Impaired smooth pursuit (HP:0007772) | 2.47867966 |
| 50 | Spastic gait (HP:0002064) | 2.47761688 |
| 51 | Absent speech (HP:0001344) | 2.47198056 |
| 52 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.44991086 |
| 53 | Delusions (HP:0000746) | 2.43567456 |
| 54 | Abnormal drinking behavior (HP:0030082) | 2.43336216 |
| 55 | Polydipsia (HP:0001959) | 2.43336216 |
| 56 | Epileptiform EEG discharges (HP:0011182) | 2.41235338 |
| 57 | Abnormal eating behavior (HP:0100738) | 2.41081195 |
| 58 | Status epilepticus (HP:0002133) | 2.37650066 |
| 59 | Abnormality of the corticospinal tract (HP:0002492) | 2.36310575 |
| 60 | Medial flaring of the eyebrow (HP:0010747) | 2.34492923 |
| 61 | Pachygyria (HP:0001302) | 2.33144809 |
| 62 | Urinary urgency (HP:0000012) | 2.30111264 |
| 63 | Progressive inability to walk (HP:0002505) | 2.27396860 |
| 64 | EEG with generalized epileptiform discharges (HP:0011198) | 2.26967549 |
| 65 | Bradykinesia (HP:0002067) | 2.25714684 |
| 66 | Postural instability (HP:0002172) | 2.24360650 |
| 67 | Chronic hepatic failure (HP:0100626) | 2.24271160 |
| 68 | Fetal akinesia sequence (HP:0001989) | 2.23774681 |
| 69 | Scanning speech (HP:0002168) | 2.22125298 |
| 70 | Neurofibrillary tangles (HP:0002185) | 2.18676480 |
| 71 | Generalized myoclonic seizures (HP:0002123) | 2.17861578 |
| 72 | Diplopia (HP:0000651) | 2.17454733 |
| 73 | Abnormality of binocular vision (HP:0011514) | 2.17454733 |
| 74 | Annular pancreas (HP:0001734) | 2.16886727 |
| 75 | Inability to walk (HP:0002540) | 2.16105992 |
| 76 | Abnormality of macular pigmentation (HP:0008002) | 2.15348643 |
| 77 | Tubular atrophy (HP:0000092) | 2.15042366 |
| 78 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.14393172 |
| 79 | Abnormality of the labia minora (HP:0012880) | 2.13693135 |
| 80 | Insidious onset (HP:0003587) | 2.12461865 |
| 81 | Termporal pattern (HP:0011008) | 2.12461865 |
| 82 | Pheochromocytoma (HP:0002666) | 2.08802274 |
| 83 | Cystic liver disease (HP:0006706) | 2.08610644 |
| 84 | Hypsarrhythmia (HP:0002521) | 2.08325427 |
| 85 | Intention tremor (HP:0002080) | 2.06770707 |
| 86 | Torticollis (HP:0000473) | 2.05483731 |
| 87 | Abnormality of the renal cortex (HP:0011035) | 2.03723406 |
| 88 | Patellar aplasia (HP:0006443) | 2.01842012 |
| 89 | Abolished electroretinogram (ERG) (HP:0000550) | 2.01599453 |
| 90 | Focal dystonia (HP:0004373) | 1.99185806 |
| 91 | Polyphagia (HP:0002591) | 1.97434967 |
| 92 | Genetic anticipation (HP:0003743) | 1.95785192 |
| 93 | Horizontal nystagmus (HP:0000666) | 1.95428678 |
| 94 | Neuroendocrine neoplasm (HP:0100634) | 1.94718975 |
| 95 | Specific learning disability (HP:0001328) | 1.92084557 |
| 96 | Gait imbalance (HP:0002141) | 1.91583287 |
| 97 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.91356980 |
| 98 | Psychosis (HP:0000709) | 1.90810776 |
| 99 | Failure to thrive in infancy (HP:0001531) | 1.89126426 |
| 100 | Stereotypic behavior (HP:0000733) | 1.88657115 |
| 101 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.88602930 |
| 102 | Impaired vibratory sensation (HP:0002495) | 1.87896687 |
| 103 | Lower limb muscle weakness (HP:0007340) | 1.85954331 |
| 104 | Severe muscular hypotonia (HP:0006829) | 1.84439046 |
| 105 | Clumsiness (HP:0002312) | 1.84027745 |
| 106 | Incomplete penetrance (HP:0003829) | 1.84019374 |
| 107 | Rapidly progressive (HP:0003678) | 1.82610765 |
| 108 | Akinesia (HP:0002304) | 1.82546808 |
| 109 | Decreased central vision (HP:0007663) | 1.82356167 |
| 110 | Generalized hypotonia (HP:0001290) | 1.81160112 |
| 111 | Sclerocornea (HP:0000647) | 1.80859803 |
| 112 | Gait ataxia (HP:0002066) | 1.80026608 |
| 113 | Cerebral hypomyelination (HP:0006808) | 1.79690995 |
| 114 | Ventricular fibrillation (HP:0001663) | 1.79361664 |
| 115 | Hypothermia (HP:0002045) | 1.78062285 |
| 116 | Intellectual disability, severe (HP:0010864) | 1.77551810 |
| 117 | Genital tract atresia (HP:0001827) | 1.76491668 |
| 118 | Polyuria (HP:0000103) | 1.76376236 |
| 119 | Craniofacial dystonia (HP:0012179) | 1.76068198 |
| 120 | Chorioretinal atrophy (HP:0000533) | 1.75946620 |
| 121 | Unsteady gait (HP:0002317) | 1.74972275 |
| 122 | Resting tremor (HP:0002322) | 1.74401876 |
| 123 | Congenital primary aphakia (HP:0007707) | 1.74310955 |
| 124 | Protruding tongue (HP:0010808) | 1.74157688 |
| 125 | Decreased circulating renin level (HP:0003351) | 1.73536321 |
| 126 | Poor suck (HP:0002033) | 1.73485644 |
| 127 | Pendular nystagmus (HP:0012043) | 1.73079588 |
| 128 | Hyperthyroidism (HP:0000836) | 1.72925025 |
| 129 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.72636909 |
| 130 | Prolonged QT interval (HP:0001657) | 1.71966009 |
| 131 | Dysmetric saccades (HP:0000641) | 1.71899316 |
| 132 | Abnormal EKG (HP:0003115) | 1.70865429 |
| 133 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.70681957 |
| 134 | Hypoplasia of the brainstem (HP:0002365) | 1.70681957 |
| 135 | Neuronal loss in central nervous system (HP:0002529) | 1.70514947 |
| 136 | Abnormality of salivation (HP:0100755) | 1.70391427 |
| 137 | Retinal dysplasia (HP:0007973) | 1.70329336 |
| 138 | Polymicrogyria (HP:0002126) | 1.69034757 |
| 139 | Oligodactyly (hands) (HP:0001180) | 1.68998270 |
| 140 | Thyroid-stimulating hormone excess (HP:0002925) | 1.68368948 |
| 141 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.68083609 |
| 142 | Agitation (HP:0000713) | 1.67990417 |
| 143 | Exotropia (HP:0000577) | 1.67946579 |
| 144 | Hemiplegia (HP:0002301) | 1.67479202 |
| 145 | Large for gestational age (HP:0001520) | 1.66297558 |
| 146 | Vaginal atresia (HP:0000148) | 1.66003464 |
| 147 | Spastic tetraplegia (HP:0002510) | 1.63447354 |
| 148 | Nephrogenic diabetes insipidus (HP:0009806) | 1.62889927 |
| 149 | Anencephaly (HP:0002323) | 1.62391337 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 4.80531898 |
| 2 | NTRK3 | 4.41923272 |
| 3 | EPHA4 | 4.28554636 |
| 4 | MAP3K9 | 3.69040211 |
| 5 | MAP3K4 | 2.96358652 |
| 6 | MARK1 | 2.92384820 |
| 7 | BMPR1B | 2.66992494 |
| 8 | MINK1 | 2.57816031 |
| 9 | CASK | 2.54258308 |
| 10 | MAP2K7 | 2.31027865 |
| 11 | DAPK2 | 2.30816676 |
| 12 | GRK5 | 2.26558499 |
| 13 | MAP4K2 | 2.22314312 |
| 14 | MAP3K12 | 2.18342641 |
| 15 | PAK6 | 2.11793989 |
| 16 | NTRK2 | 2.06007985 |
| 17 | PNCK | 2.03409020 |
| 18 | RIPK4 | 1.96575861 |
| 19 | DAPK1 | 1.96054610 |
| 20 | KSR2 | 1.90849302 |
| 21 | MAP2K4 | 1.85959152 |
| 22 | NTRK1 | 1.85809411 |
| 23 | SIK2 | 1.72046255 |
| 24 | ZAK | 1.68841284 |
| 25 | WNK4 | 1.68172424 |
| 26 | INSRR | 1.66850676 |
| 27 | PRPF4B | 1.66435841 |
| 28 | ARAF | 1.64652169 |
| 29 | CDK19 | 1.53759221 |
| 30 | UHMK1 | 1.53207622 |
| 31 | TLK1 | 1.51678541 |
| 32 | GRK1 | 1.51530144 |
| 33 | TYRO3 | 1.49143285 |
| 34 | CDK5 | 1.40956734 |
| 35 | PRKD3 | 1.40765481 |
| 36 | KSR1 | 1.40192973 |
| 37 | PHKG1 | 1.38378184 |
| 38 | PHKG2 | 1.38378184 |
| 39 | PLK2 | 1.33547486 |
| 40 | NME1 | 1.23203499 |
| 41 | STK38 | 1.22474365 |
| 42 | MAPK15 | 1.20632037 |
| 43 | PRKCG | 1.17728117 |
| 44 | TNIK | 1.16802711 |
| 45 | MAPK13 | 1.15992637 |
| 46 | PKN1 | 1.14665771 |
| 47 | CAMK2A | 1.11297019 |
| 48 | MAP3K13 | 1.07038079 |
| 49 | FES | 1.06014247 |
| 50 | NUAK1 | 1.02281799 |
| 51 | MKNK2 | 0.99418670 |
| 52 | CAMK2B | 0.99233749 |
| 53 | LATS2 | 0.97943374 |
| 54 | CAMKK1 | 0.96376703 |
| 55 | MAP2K6 | 0.95269722 |
| 56 | CSNK1A1L | 0.94305390 |
| 57 | CDK14 | 0.93962451 |
| 58 | CDK18 | 0.93782028 |
| 59 | CDK15 | 0.92894179 |
| 60 | AKT3 | 0.87980766 |
| 61 | FGR | 0.86722606 |
| 62 | GRK6 | 0.85272897 |
| 63 | MARK2 | 0.84164726 |
| 64 | MUSK | 0.83946293 |
| 65 | CDK11A | 0.83752423 |
| 66 | RAF1 | 0.82114214 |
| 67 | PINK1 | 0.80897196 |
| 68 | BMPR2 | 0.80251119 |
| 69 | DYRK1A | 0.79388518 |
| 70 | GRK7 | 0.77454600 |
| 71 | CSNK1G1 | 0.76248059 |
| 72 | FGFR2 | 0.76237570 |
| 73 | STK39 | 0.75367232 |
| 74 | ACVR1B | 0.73753544 |
| 75 | TAOK1 | 0.73196032 |
| 76 | STK11 | 0.72210697 |
| 77 | MAP3K2 | 0.72157871 |
| 78 | CSNK1G2 | 0.71843110 |
| 79 | PAK3 | 0.67048598 |
| 80 | OXSR1 | 0.65203100 |
| 81 | CAMK1 | 0.64271737 |
| 82 | SGK2 | 0.63330356 |
| 83 | TAOK3 | 0.61595446 |
| 84 | PRKAA1 | 0.61231373 |
| 85 | ALK | 0.60901451 |
| 86 | PTK2B | 0.60645508 |
| 87 | CDK3 | 0.57894813 |
| 88 | CAMK2D | 0.57644917 |
| 89 | ICK | 0.57339524 |
| 90 | OBSCN | 0.57299849 |
| 91 | CAMK1G | 0.56979136 |
| 92 | SGK494 | 0.54427285 |
| 93 | SGK223 | 0.54427285 |
| 94 | NEK1 | 0.54321642 |
| 95 | CAMK2G | 0.53940645 |
| 96 | CAMK1D | 0.53491264 |
| 97 | TNK2 | 0.52413082 |
| 98 | CSNK1D | 0.51441502 |
| 99 | STK38L | 0.51094726 |
| 100 | BRAF | 0.50923413 |
| 101 | MAPK10 | 0.50901244 |
| 102 | SGK1 | 0.50278395 |
| 103 | ADRBK1 | 0.49743865 |
| 104 | BCKDK | 0.47650965 |
| 105 | VRK1 | 0.47128222 |
| 106 | MAP3K6 | 0.46940101 |
| 107 | DAPK3 | 0.46077985 |
| 108 | CSNK1A1 | 0.44681699 |
| 109 | CSNK1G3 | 0.44458332 |
| 110 | CSNK1E | 0.43426375 |
| 111 | PRKCH | 0.43157304 |
| 112 | ADRBK2 | 0.43136914 |
| 113 | PRKD2 | 0.42528492 |
| 114 | CAMK4 | 0.42523441 |
| 115 | PRKG1 | 0.42410344 |
| 116 | TGFBR1 | 0.42318481 |
| 117 | PRKCZ | 0.42259950 |
| 118 | WNK1 | 0.41995012 |
| 119 | BCR | 0.41353307 |
| 120 | RPS6KA3 | 0.41121848 |
| 121 | NEK6 | 0.40309956 |
| 122 | WNK3 | 0.39039102 |
| 123 | MAP3K7 | 0.38724626 |
| 124 | CDC42BPA | 0.38306509 |
| 125 | TRIM28 | 0.37958369 |
| 126 | GSK3B | 0.37832083 |
| 127 | CAMKK2 | 0.37786308 |
| 128 | ERBB2 | 0.36237294 |
| 129 | PRKACB | 0.35845712 |
| 130 | MAPK8 | 0.35804122 |
| 131 | MAP3K1 | 0.34601534 |
| 132 | PDK1 | 0.33857495 |
| 133 | MAP3K11 | 0.33517532 |
| 134 | PRKCE | 0.33154247 |
| 135 | RET | 0.33021521 |
| 136 | PRKCA | 0.32863738 |
| 137 | PRKACA | 0.32470002 |
| 138 | MOS | 0.31297419 |
| 139 | FYN | 0.31281211 |
| 140 | SIK3 | 0.31269500 |
| 141 | DYRK2 | 0.31214238 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.39394570 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.59329791 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.88736213 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.87124410 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.86246553 |
| 6 | Long-term potentiation_Homo sapiens_hsa04720 | 2.72913800 |
| 7 | Circadian entrainment_Homo sapiens_hsa04713 | 2.67285090 |
| 8 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.64396852 |
| 9 | Morphine addiction_Homo sapiens_hsa05032 | 2.63302904 |
| 10 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.62550023 |
| 11 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.30949181 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.30054073 |
| 13 | Taste transduction_Homo sapiens_hsa04742 | 2.18468809 |
| 14 | Salivary secretion_Homo sapiens_hsa04970 | 2.14608096 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 2.02384701 |
| 16 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.88437262 |
| 17 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.84315799 |
| 18 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.82064926 |
| 19 | Long-term depression_Homo sapiens_hsa04730 | 1.81681291 |
| 20 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.81421883 |
| 21 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.70211282 |
| 22 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.67985984 |
| 23 | Renin secretion_Homo sapiens_hsa04924 | 1.66771036 |
| 24 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.66685295 |
| 25 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.66211369 |
| 26 | Cocaine addiction_Homo sapiens_hsa05030 | 1.63307825 |
| 27 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.61429604 |
| 28 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.54027588 |
| 29 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.53341121 |
| 30 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.47287499 |
| 31 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.46992299 |
| 32 | Gap junction_Homo sapiens_hsa04540 | 1.46642828 |
| 33 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.41397947 |
| 34 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.35028818 |
| 35 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.31746320 |
| 36 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.31449707 |
| 37 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.28615765 |
| 38 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.26943906 |
| 39 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.24853129 |
| 40 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.22403819 |
| 41 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.18083094 |
| 42 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.17854123 |
| 43 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.13821504 |
| 44 | ABC transporters_Homo sapiens_hsa02010 | 1.12984813 |
| 45 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.10718827 |
| 46 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.10642270 |
| 47 | Axon guidance_Homo sapiens_hsa04360 | 1.08775963 |
| 48 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.08646720 |
| 49 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.08409670 |
| 50 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.05352045 |
| 51 | Alzheimers disease_Homo sapiens_hsa05010 | 1.03481372 |
| 52 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.03401017 |
| 53 | Phototransduction_Homo sapiens_hsa04744 | 1.03269131 |
| 54 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.02432263 |
| 55 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.02203592 |
| 56 | Sulfur relay system_Homo sapiens_hsa04122 | 0.99552785 |
| 57 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.97874888 |
| 58 | Melanogenesis_Homo sapiens_hsa04916 | 0.97647655 |
| 59 | Parkinsons disease_Homo sapiens_hsa05012 | 0.96747824 |
| 60 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.93822058 |
| 61 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.93326286 |
| 62 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.93300215 |
| 63 | Glioma_Homo sapiens_hsa05214 | 0.89646432 |
| 64 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.89410484 |
| 65 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.87351903 |
| 66 | Basal transcription factors_Homo sapiens_hsa03022 | 0.85519678 |
| 67 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.84706915 |
| 68 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.84177858 |
| 69 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.83777105 |
| 70 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.82367300 |
| 71 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.77298253 |
| 72 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.75413077 |
| 73 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.73516974 |
| 74 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.73467287 |
| 75 | Huntingtons disease_Homo sapiens_hsa05016 | 0.70341735 |
| 76 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.69627881 |
| 77 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.69464449 |
| 78 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.69420192 |
| 79 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.67828791 |
| 80 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.67266420 |
| 81 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.67148611 |
| 82 | Alcoholism_Homo sapiens_hsa05034 | 0.66034267 |
| 83 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.64183255 |
| 84 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.63654655 |
| 85 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.63520860 |
| 86 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.62961449 |
| 87 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.57838461 |
| 88 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.56267117 |
| 89 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.56055626 |
| 90 | RNA polymerase_Homo sapiens_hsa03020 | 0.55878803 |
| 91 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.55675161 |
| 92 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.54261727 |
| 93 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.53902767 |
| 94 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.53688179 |
| 95 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.53471179 |
| 96 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.52677278 |
| 97 | Homologous recombination_Homo sapiens_hsa03440 | 0.51273128 |
| 98 | Bile secretion_Homo sapiens_hsa04976 | 0.51135931 |
| 99 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.48847533 |
| 100 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.48829281 |
| 101 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.48738704 |
| 102 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.48039642 |
| 103 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.47573387 |
| 104 | Lysine degradation_Homo sapiens_hsa00310 | 0.47501263 |
| 105 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.47273372 |
| 106 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.47109397 |
| 107 | Circadian rhythm_Homo sapiens_hsa04710 | 0.46075743 |
| 108 | Peroxisome_Homo sapiens_hsa04146 | 0.45927905 |
| 109 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.44776076 |
| 110 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.44746799 |
| 111 | Prion diseases_Homo sapiens_hsa05020 | 0.43425311 |
| 112 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.40635553 |
| 113 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.39986990 |
| 114 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.39883540 |
| 115 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.38691502 |
| 116 | Histidine metabolism_Homo sapiens_hsa00340 | 0.36940363 |
| 117 | Endocytosis_Homo sapiens_hsa04144 | 0.35571411 |
| 118 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.34029325 |
| 119 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.33959189 |
| 120 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.33761748 |
| 121 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.33613664 |
| 122 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.32935549 |
| 123 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.31818357 |
| 124 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.30240841 |
| 125 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.29187507 |
| 126 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.28958858 |
| 127 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.27500751 |
| 128 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.27233471 |
| 129 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.26733998 |
| 130 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.26348419 |
| 131 | Endometrial cancer_Homo sapiens_hsa05213 | 0.22232832 |
| 132 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.21251734 |
| 133 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.20508777 |
| 134 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.20080561 |
| 135 | Colorectal cancer_Homo sapiens_hsa05210 | 0.18923905 |
| 136 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.18733182 |

