RPS6P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1base-excision repair, AP site formation (GO:0006285)6.22279332
2aldehyde catabolic process (GO:0046185)5.83979912
3purine deoxyribonucleotide catabolic process (GO:0009155)5.39714584
4water-soluble vitamin biosynthetic process (GO:0042364)5.37637720
5cell wall macromolecule metabolic process (GO:0044036)5.03018740
6ribosomal large subunit biogenesis (GO:0042273)4.88971135
7regulation of translational termination (GO:0006449)4.85557223
8aspartate family amino acid catabolic process (GO:0009068)4.72711743
9galactose catabolic process (GO:0019388)4.59042215
10mitochondrial RNA metabolic process (GO:0000959)4.46442266
11interleukin-6-mediated signaling pathway (GO:0070102)4.41460116
12DNA deamination (GO:0045006)4.31123767
13purine nucleotide salvage (GO:0032261)4.26544888
14grooming behavior (GO:0007625)4.19079679
15purine deoxyribonucleotide metabolic process (GO:0009151)4.14198638
16vitamin catabolic process (GO:0009111)4.10083573
17fat-soluble vitamin catabolic process (GO:0042363)4.10083573
18glucosamine-containing compound catabolic process (GO:1901072)4.03599257
19ribosome assembly (GO:0042255)3.90759886
20purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.83880690
21behavioral response to ethanol (GO:0048149)3.73943095
22deoxyribonucleotide catabolic process (GO:0009264)3.73663687
23protein-cofactor linkage (GO:0018065)3.72986615
24cullin deneddylation (GO:0010388)3.68460251
25magnesium ion transport (GO:0015693)3.65662290
26single strand break repair (GO:0000012)3.65405666
27DNA double-strand break processing (GO:0000729)3.64245705
28DNA catabolic process, exonucleolytic (GO:0000738)3.63941554
29viral mRNA export from host cell nucleus (GO:0046784)3.58165821
30dicarboxylic acid catabolic process (GO:0043649)3.57977194
31adenosine metabolic process (GO:0046085)3.56741513
32vitamin biosynthetic process (GO:0009110)3.52386040
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50761800
34rRNA modification (GO:0000154)3.48400105
35deoxyribose phosphate catabolic process (GO:0046386)3.44446631
36negative regulation of thymocyte apoptotic process (GO:0070244)3.38809841
37negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.38780837
38behavioral response to nicotine (GO:0035095)3.37017956
39positive regulation of B cell differentiation (GO:0045579)3.31948388
40pseudouridine synthesis (GO:0001522)3.28110315
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.27671224
42protein deneddylation (GO:0000338)3.27197185
43tRNA aminoacylation for protein translation (GO:0006418)3.21166636
44amino acid activation (GO:0043038)3.17576258
45tRNA aminoacylation (GO:0043039)3.17576258
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16600302
47ATP synthesis coupled proton transport (GO:0015986)3.16600302
48tRNA modification (GO:0006400)3.13561816
49mismatch repair (GO:0006298)3.12319466
50replication fork processing (GO:0031297)3.08334628
51thrombin receptor signaling pathway (GO:0070493)3.07991607
52RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04078938
53positive regulation of chemokine secretion (GO:0090197)3.02453048
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00732938
55protein neddylation (GO:0045116)3.00470529
56rRNA methylation (GO:0031167)2.99802364
57tRNA metabolic process (GO:0006399)2.99624116
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99488309
59histamine secretion (GO:0001821)2.98861923
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97600550
61maturation of 5.8S rRNA (GO:0000460)2.97178254
62deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.91767419
63DNA demethylation (GO:0080111)2.90942150
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89949365
65regulation of mitotic spindle checkpoint (GO:1903504)2.89949365
66negative regulation of interleukin-1 beta production (GO:0032691)2.88984842
672-deoxyribonucleotide metabolic process (GO:0009394)2.88307643
68chaperone mediated protein folding requiring cofactor (GO:0051085)2.87475149
69proteasome assembly (GO:0043248)2.87043656
70response to nitrosative stress (GO:0051409)2.86938249
71GTP biosynthetic process (GO:0006183)2.85287070
72ncRNA catabolic process (GO:0034661)2.84022529
73aggressive behavior (GO:0002118)2.83411118
74regulation of cellular amino acid metabolic process (GO:0006521)2.83081776
75immunoglobulin mediated immune response (GO:0016064)2.82952805
76purine-containing compound salvage (GO:0043101)2.80716163
77negative regulation of ligase activity (GO:0051352)2.79047542
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79047542
79production of molecular mediator involved in inflammatory response (GO:0002532)2.77367398
80cellular anion homeostasis (GO:0030002)2.77326559
81centriole replication (GO:0007099)2.77182601
82nuclear pore organization (GO:0006999)2.76704695
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.76231117
84NADH dehydrogenase complex assembly (GO:0010257)2.76231117
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76231117
86tRNA processing (GO:0008033)2.76072438
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74453054
88purine nucleobase biosynthetic process (GO:0009113)2.72917098
89AMP metabolic process (GO:0046033)2.71033648
90B cell mediated immunity (GO:0019724)2.70666052
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70504335
92rRNA processing (GO:0006364)2.68323386
93negative regulation of DNA-templated transcription, elongation (GO:0032785)2.68056470
94DNA catabolic process (GO:0006308)2.67324256
95positive regulation of histone H3-K4 methylation (GO:0051571)2.66921504
96rRNA metabolic process (GO:0016072)2.66119211
97mitochondrial respiratory chain complex assembly (GO:0033108)2.64301362
98L-ascorbic acid metabolic process (GO:0019852)2.63752263
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62105989
100aspartate family amino acid metabolic process (GO:0009066)2.61474522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62986980
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.20854405
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.83210939
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47858664
5VDR_22108803_ChIP-Seq_LS180_Human3.42560412
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32618877
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92887873
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91349974
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.83702493
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73279312
11ELK1_19687146_ChIP-ChIP_HELA_Human2.71488139
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.70305584
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66823143
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.64482280
15VDR_23849224_ChIP-Seq_CD4+_Human2.64392927
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.63278616
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43065438
18FOXP3_21729870_ChIP-Seq_TREG_Human2.36838878
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.26796948
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24843051
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23920710
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.23796009
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.16530901
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14601993
25IGF1R_20145208_ChIP-Seq_DFB_Human2.13776133
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13591245
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10236804
28ZNF274_21170338_ChIP-Seq_K562_Hela2.01954806
29MYC_18940864_ChIP-ChIP_HL60_Human1.94661538
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89691829
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85401006
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77655389
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.75704467
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74878215
35EWS_26573619_Chip-Seq_HEK293_Human1.71797150
36CIITA_25753668_ChIP-Seq_RAJI_Human1.68833045
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65597156
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.64342945
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63899314
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.60099069
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.59574896
42FUS_26573619_Chip-Seq_HEK293_Human1.54580954
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54062838
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.53406870
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50083336
46TP53_22573176_ChIP-Seq_HFKS_Human1.43769372
47DCP1A_22483619_ChIP-Seq_HELA_Human1.42264532
48BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41918106
49AR_20517297_ChIP-Seq_VCAP_Human1.39511909
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38930955
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38314153
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36155757
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35438667
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33679419
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28916194
56TTF2_22483619_ChIP-Seq_HELA_Human1.28365854
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28280586
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22503888
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22139573
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21122113
61GBX2_23144817_ChIP-Seq_PC3_Human1.15551359
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15230317
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13978353
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13781300
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.13781300
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13128514
67GATA3_26560356_Chip-Seq_TH2_Human1.13113364
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11138320
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09100633
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06079615
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.04322089
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03682335
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03308076
74CBP_20019798_ChIP-Seq_JUKART_Human1.03308076
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.02134484
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00899280
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98834547
78HOXB7_26014856_ChIP-Seq_BT474_Human0.98742215
79YY1_22570637_ChIP-Seq_MALME-3M_Human0.96106221
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95877064
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95562930
82SOX2_19829295_ChIP-Seq_ESCs_Human0.95480912
83NANOG_19829295_ChIP-Seq_ESCs_Human0.95480912
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94526200
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93764299
86XRN2_22483619_ChIP-Seq_HELA_Human0.93702402
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93263937
88NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92941468
89P300_19829295_ChIP-Seq_ESCs_Human0.92259857
90GABP_19822575_ChIP-Seq_HepG2_Human0.91895658
91TAF15_26573619_Chip-Seq_HEK293_Human0.90780184
92SPI1_23547873_ChIP-Seq_NB4_Human0.89186118
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89143176
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89009926
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88153680
96GATA3_26560356_Chip-Seq_TH1_Human0.88148594
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87992616
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86953303
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86642504
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86308156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland5.13284741
2MP0003806_abnormal_nucleotide_metabolis4.61547839
3MP0003303_peritoneal_inflammation4.36652087
4MP0001764_abnormal_homeostasis3.64174263
5MP0002736_abnormal_nociception_after3.11444119
6MP0002138_abnormal_hepatobiliary_system3.02782028
7MP0001968_abnormal_touch/_nociception2.92731031
8MP0008877_abnormal_DNA_methylation2.74530666
9MP0005084_abnormal_gallbladder_morpholo2.70729076
10MP0009697_abnormal_copulation2.62228315
11MP0008058_abnormal_DNA_repair2.40560859
12MP0008775_abnormal_heart_ventricle2.36730190
13MP0003718_maternal_effect2.32258605
14MP0002160_abnormal_reproductive_system2.07685678
15MP0002396_abnormal_hematopoietic_system1.96024863
16MP0005389_reproductive_system_phenotype1.81224341
17MP0002139_abnormal_hepatobiliary_system1.77459773
18MP0008004_abnormal_stomach_pH1.76844105
19MP0006036_abnormal_mitochondrial_physio1.74137032
20MP0004782_abnormal_surfactant_physiolog1.65287020
21MP0000230_abnormal_systemic_arterial1.60649832
22MP0005464_abnormal_platelet_physiology1.57962088
23MP0004957_abnormal_blastocyst_morpholog1.57696730
24MP0001984_abnormal_olfaction1.54488530
25MP0003567_abnormal_fetal_cardiomyocyte1.51405376
26MP0005220_abnormal_exocrine_pancreas1.46480913
27MP0001440_abnormal_grooming_behavior1.45687616
28MP0008872_abnormal_physiological_respon1.44502469
29MP0003111_abnormal_nucleus_morphology1.42738199
30MP0010094_abnormal_chromosome_stability1.40555189
31MP0004043_abnormal_pH_regulation1.38350417
32MP0001542_abnormal_bone_strength1.35170331
33MP0006072_abnormal_retinal_apoptosis1.33580922
34MP0010368_abnormal_lymphatic_system1.33421951
35MP0002837_dystrophic_cardiac_calcinosis1.25914247
36MP0008995_early_reproductive_senescence1.23544947
37MP0001919_abnormal_reproductive_system1.23304555
38MP0005410_abnormal_fertilization1.22069108
39MP0001663_abnormal_digestive_system1.20927951
40MP0003693_abnormal_embryo_hatching1.20385452
41MP0005266_abnormal_metabolism1.20371536
42MP0006054_spinal_hemorrhage1.18989565
43MP0003195_calcinosis1.18959882
44MP0009764_decreased_sensitivity_to1.17633825
45MP0004215_abnormal_myocardial_fiber1.14393546
46MP0004145_abnormal_muscle_electrophysio1.12835400
47MP0003724_increased_susceptibility_to1.12733249
48MP0008789_abnormal_olfactory_epithelium1.12159909
49MP0004084_abnormal_cardiac_muscle1.12061972
50MP0005332_abnormal_amino_acid1.10709166
51MP0009765_abnormal_xenobiotic_induced1.10097890
52MP0008007_abnormal_cellular_replicative1.08245307
53MP0005376_homeostasis/metabolism_phenot1.08243835
54MP0008932_abnormal_embryonic_tissue1.08006562
55MP0000372_irregular_coat_pigmentation1.06560295
56MP0002735_abnormal_chemical_nociception1.05105049
57MP0001544_abnormal_cardiovascular_syste1.04552961
58MP0005385_cardiovascular_system_phenoty1.04552961
59MP0008873_increased_physiological_sensi1.03026732
60MP0006276_abnormal_autonomic_nervous1.02710511
61MP0002089_abnormal_postnatal_growth/wei1.02651162
62MP0002332_abnormal_exercise_endurance1.01393863
63MP0002254_reproductive_system_inflammat1.00772624
64MP0001853_heart_inflammation0.98177599
65MP0005551_abnormal_eye_electrophysiolog0.98010365
66MP0006035_abnormal_mitochondrial_morpho0.96784651
67MP0006138_congestive_heart_failure0.96496889
68MP0003077_abnormal_cell_cycle0.95551973
69MP0003186_abnormal_redox_activity0.94629263
70MP0005319_abnormal_enzyme/_coenzyme0.94438380
71MP0008875_abnormal_xenobiotic_pharmacok0.91178759
72MP0001835_abnormal_antigen_presentation0.89064312
73MP0001664_abnormal_digestion0.84357370
74MP0003252_abnormal_bile_duct0.83292930
75MP0005595_abnormal_vascular_smooth0.81331722
76MP0004019_abnormal_vitamin_homeostasis0.78559043
77MP0001177_atelectasis0.75962642
78MP0002019_abnormal_tumor_incidence0.74533267
79MP0001765_abnormal_ion_homeostasis0.73574488
80MP0004036_abnormal_muscle_relaxation0.73283514
81MP0000689_abnormal_spleen_morphology0.72384867
82MP0000467_abnormal_esophagus_morphology0.72048755
83MP0003646_muscle_fatigue0.71097432
84MP0001929_abnormal_gametogenesis0.70032583
85MP0005381_digestive/alimentary_phenotyp0.69142156
86MP0002148_abnormal_hypersensitivity_rea0.69139841
87MP0005075_abnormal_melanosome_morpholog0.68519974
88MP0002277_abnormal_respiratory_mucosa0.68030015
89MP0003786_premature_aging0.67374966
90MP0004484_altered_response_of0.66978516
91MP0005000_abnormal_immune_tolerance0.63791027
92MP0004147_increased_porphyrin_level0.63518896
93MP0003436_decreased_susceptibility_to0.62597266
94MP0001293_anophthalmia0.62384754
95MP0002733_abnormal_thermal_nociception0.61356795
96MP0008469_abnormal_protein_level0.60204900
97MP0001881_abnormal_mammary_gland0.59706312
98MP0001873_stomach_inflammation0.57017427
99MP0001800_abnormal_humoral_immune0.56871349
100MP0001756_abnormal_urination0.56230532

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)8.48717295
2Absent/shortened dynein arms (HP:0200106)5.90899368
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.90899368
4Stomach cancer (HP:0012126)4.84819853
5Abnormal respiratory motile cilium morphology (HP:0005938)4.43759480
6Abnormal respiratory epithelium morphology (HP:0012253)4.43759480
7Abnormal ciliary motility (HP:0012262)3.90821876
8Abnormality of methionine metabolism (HP:0010901)3.89127860
9Colon cancer (HP:0003003)3.83950928
10Abnormality of aspartate family amino acid metabolism (HP:0010899)3.66689680
11Methylmalonic aciduria (HP:0012120)3.61134836
12Abnormality of sulfur amino acid metabolism (HP:0004339)3.52907519
13Methylmalonic acidemia (HP:0002912)3.50475126
14Abnormal number of erythroid precursors (HP:0012131)3.38307337
15Osteomalacia (HP:0002749)3.29871461
16Absent thumb (HP:0009777)3.05610625
17Papilledema (HP:0001085)2.98182428
18Abnormal respiratory motile cilium physiology (HP:0012261)2.97511787
19Abolished electroretinogram (ERG) (HP:0000550)2.97447395
20Abnormality of the prostate (HP:0008775)2.95413282
21Acute necrotizing encephalopathy (HP:0006965)2.85248509
22Volvulus (HP:0002580)2.80743579
23Atonic seizures (HP:0010819)2.79507031
24Abnormality of cells of the erythroid lineage (HP:0012130)2.79405665
25Abnormality of homocysteine metabolism (HP:0010919)2.77928083
26Homocystinuria (HP:0002156)2.77928083
27Amyotrophic lateral sclerosis (HP:0007354)2.69779125
28Limb hypertonia (HP:0002509)2.60553628
29Premature ovarian failure (HP:0008209)2.57039828
30Acute encephalopathy (HP:0006846)2.54145977
31Abnormal mitochondria in muscle tissue (HP:0008316)2.52680610
32Abnormality of the vitamin B12 metabolism (HP:0004341)2.45426026
33Progressive macrocephaly (HP:0004481)2.44256589
343-Methylglutaconic aciduria (HP:0003535)2.43560862
35Increased serum lactate (HP:0002151)2.41173005
36Abnormal spermatogenesis (HP:0008669)2.37856888
37Pancreatic cysts (HP:0001737)2.36850405
38Type I transferrin isoform profile (HP:0003642)2.33963253
39Panhypogammaglobulinemia (HP:0003139)2.33000633
40Abnormality of renal resorption (HP:0011038)2.32744658
41Abnormality of macular pigmentation (HP:0008002)2.24706519
42Abnormality of vitamin B metabolism (HP:0004340)2.23127550
43Hypergonadotropic hypogonadism (HP:0000815)2.21512988
44Attenuation of retinal blood vessels (HP:0007843)2.12276541
45Increased CSF lactate (HP:0002490)2.12146802
46Recurrent sinusitis (HP:0011108)2.10717125
47Aplastic anemia (HP:0001915)2.06760937
48Palpitations (HP:0001962)2.06752571
49Mitochondrial inheritance (HP:0001427)2.05057207
50Decreased central vision (HP:0007663)2.04968804
51Metabolic acidosis (HP:0001942)2.04893494
52Cerebral edema (HP:0002181)2.04243561
53Ketoacidosis (HP:0001993)2.02945824
54Abnormality of serum amino acid levels (HP:0003112)1.99412093
55Pancreatic fibrosis (HP:0100732)1.98179454
56Macrocytic anemia (HP:0001972)1.98052039
57Lactic acidosis (HP:0003128)1.94216239
58Pendular nystagmus (HP:0012043)1.93257686
59Lethargy (HP:0001254)1.90133813
60Chronic otitis media (HP:0000389)1.90074161
61Hyperammonemia (HP:0001987)1.87361915
62Infantile muscular hypotonia (HP:0008947)1.87155229
63True hermaphroditism (HP:0010459)1.85413770
64Elevated erythrocyte sedimentation rate (HP:0003565)1.85135689
65Dry hair (HP:0011359)1.84997866
66Atrophy/Degeneration involving motor neurons (HP:0007373)1.84250682
67Increased serum pyruvate (HP:0003542)1.79953004
68Abnormal drinking behavior (HP:0030082)1.77513880
69Polydipsia (HP:0001959)1.77513880
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77307249
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77307249
72Ketosis (HP:0001946)1.75855759
73Short tibia (HP:0005736)1.75435856
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72659909
75Bilateral microphthalmos (HP:0007633)1.69024836
76Increased hepatocellular lipid droplets (HP:0006565)1.68898484
77Dialeptic seizures (HP:0011146)1.67769589
78Microvesicular hepatic steatosis (HP:0001414)1.67573793
79Abnormality of male internal genitalia (HP:0000022)1.67457092
80Ectopic kidney (HP:0000086)1.67126186
81Hyperglycinuria (HP:0003108)1.67034739
82Myoglobinuria (HP:0002913)1.66290873
83Vascular calcification (HP:0004934)1.66185975
84Oral leukoplakia (HP:0002745)1.65834162
85Mesangial abnormality (HP:0001966)1.65174736
86Long nose (HP:0003189)1.65083285
87Spastic tetraparesis (HP:0001285)1.63191175
88Myelodysplasia (HP:0002863)1.63084549
89Medial flaring of the eyebrow (HP:0010747)1.61098031
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.60977883
91Respiratory failure (HP:0002878)1.60394323
92Lipid accumulation in hepatocytes (HP:0006561)1.58692070
93Dicarboxylic aciduria (HP:0003215)1.58020990
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.58020990
95Neoplasm of the colon (HP:0100273)1.57900738
96Abnormality of renal excretion (HP:0011036)1.56521489
97Hypoproteinemia (HP:0003075)1.55636083
98Abnormal protein N-linked glycosylation (HP:0012347)1.55386090
99Abnormal protein glycosylation (HP:0012346)1.55386090
100Abnormal glycosylation (HP:0012345)1.55386090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.54084720
2EIF2AK35.09210419
3STK164.81444441
4ZAK3.28890930
5TEC2.95423545
6FRK2.61219308
7PBK2.59093153
8TLK12.30817585
9SIK22.23986523
10ITK2.07054911
11TIE12.03359828
12TNIK2.02966302
13TAOK31.81046422
14FES1.80989806
15WNK31.75873115
16PLK41.67693580
17OXSR11.64924159
18PLK31.63344301
19TTK1.58395553
20SRPK11.57112458
21IRAK41.53859590
22NEK21.38764355
23NUAK11.38581807
24CDC71.37162362
25CDK191.34217419
26KDR1.33987497
27BTK1.31886036
28MST41.31477411
29EIF2AK21.20320456
30PIK3CA1.20284146
31IRAK11.13997052
32VRK21.08911174
33PHKG21.01213150
34PHKG11.01213150
35SYK0.96779648
36RPS6KB20.91875530
37GRK10.90334984
38IKBKE0.87100846
39EIF2AK10.87002090
40TSSK60.86679138
41PRKG20.84235537
42ADRBK20.83345290
43PIK3CG0.82112094
44IKBKB0.81502887
45SCYL20.79038403
46VRK10.78989928
47KIT0.78709142
48NEK10.78377034
49WNK40.78362415
50SIK30.76081509
51MAPKAPK30.75102622
52TBK10.73175513
53IRAK20.71588420
54NEK60.70814331
55LYN0.70245141
56BUB10.68666291
57CHEK20.68235879
58ABL20.65625688
59ATM0.64465524
60PLK20.59225455
61MKNK10.57392333
62PLK10.57376834
63DAPK20.56069926
64ABL10.55858866
65TRPM70.54434976
66PAK20.52151278
67BRSK20.52077756
68ERBB30.50516148
69PINK10.49135554
70IGF1R0.48385068
71MAPKAPK50.47859127
72ATR0.44944381
73TRIM280.44481515
74ZAP700.43238733
75HCK0.43201964
76LCK0.42512214
77ADRBK10.41486770
78BRD40.40624744
79MAP3K140.40602210
80MAP2K60.40125645
81BMPR20.39609269
82FGFR20.39477078
83INSRR0.39288472
84PRKCQ0.38429609
85CDK90.37152419
86FER0.35786596
87STK390.35629189
88BMPR1B0.34079306
89CCNB10.33270146
90GRK70.32440387
91CSNK2A10.31612891
92TESK20.31437003
93AURKB0.30015909
94PRKCA0.29578220
95MARK30.29056516
96RPS6KA10.28187453
97WNK10.27525880
98CHUK0.27242905
99DYRK1A0.27127258
100FLT30.24912130

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.07399745
2Proteasome_Homo sapiens_hsa030503.44450022
3Allograft rejection_Homo sapiens_hsa053303.15144603
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.94567021
5Autoimmune thyroid disease_Homo sapiens_hsa053202.84938855
6Graft-versus-host disease_Homo sapiens_hsa053322.74904525
7Homologous recombination_Homo sapiens_hsa034402.70079107
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61423953
9Type I diabetes mellitus_Homo sapiens_hsa049402.44591367
10Base excision repair_Homo sapiens_hsa034102.17234728
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16822058
12Fatty acid elongation_Homo sapiens_hsa000621.95324486
13Sulfur metabolism_Homo sapiens_hsa009201.92188164
14Ribosome_Homo sapiens_hsa030101.80986255
15Fanconi anemia pathway_Homo sapiens_hsa034601.79138148
16Spliceosome_Homo sapiens_hsa030401.77253066
17Protein export_Homo sapiens_hsa030601.69639167
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69043641
19Mismatch repair_Homo sapiens_hsa034301.64686730
20Oxidative phosphorylation_Homo sapiens_hsa001901.63765164
21Staphylococcus aureus infection_Homo sapiens_hsa051501.63504300
22Antigen processing and presentation_Homo sapiens_hsa046121.60422058
23RNA polymerase_Homo sapiens_hsa030201.59389895
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54633940
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54509813
26Leishmaniasis_Homo sapiens_hsa051401.49390443
27Phototransduction_Homo sapiens_hsa047441.45561192
28Parkinsons disease_Homo sapiens_hsa050121.42370757
29DNA replication_Homo sapiens_hsa030301.40378873
30Non-homologous end-joining_Homo sapiens_hsa034501.27736928
31RNA transport_Homo sapiens_hsa030131.27211457
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26732566
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25446996
34Rheumatoid arthritis_Homo sapiens_hsa053231.23098374
35Caffeine metabolism_Homo sapiens_hsa002321.22343631
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21927743
37Selenocompound metabolism_Homo sapiens_hsa004501.20658279
38RNA degradation_Homo sapiens_hsa030181.18748448
39Tryptophan metabolism_Homo sapiens_hsa003801.15589639
40Viral myocarditis_Homo sapiens_hsa054161.14489915
41Chemical carcinogenesis_Homo sapiens_hsa052041.10666396
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10383690
43Linoleic acid metabolism_Homo sapiens_hsa005911.06473922
44Nucleotide excision repair_Homo sapiens_hsa034201.03414795
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.03329617
46Purine metabolism_Homo sapiens_hsa002300.97992892
47Arachidonic acid metabolism_Homo sapiens_hsa005900.95946502
48Systemic lupus erythematosus_Homo sapiens_hsa053220.95025289
49Fatty acid degradation_Homo sapiens_hsa000710.93726702
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89029164
51Propanoate metabolism_Homo sapiens_hsa006400.86902789
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86660619
53Vitamin digestion and absorption_Homo sapiens_hsa049770.86094192
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84784588
55Regulation of autophagy_Homo sapiens_hsa041400.83880030
56Peroxisome_Homo sapiens_hsa041460.83273197
57Sulfur relay system_Homo sapiens_hsa041220.83083211
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81437387
59Alzheimers disease_Homo sapiens_hsa050100.79218761
60Retinol metabolism_Homo sapiens_hsa008300.77773231
61Huntingtons disease_Homo sapiens_hsa050160.76985962
62Nitrogen metabolism_Homo sapiens_hsa009100.76749474
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73805102
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70957397
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70757867
66Basal transcription factors_Homo sapiens_hsa030220.69035023
67Pyrimidine metabolism_Homo sapiens_hsa002400.68549310
68Pyruvate metabolism_Homo sapiens_hsa006200.64074213
69Fatty acid metabolism_Homo sapiens_hsa012120.62861900
70One carbon pool by folate_Homo sapiens_hsa006700.61884215
71Herpes simplex infection_Homo sapiens_hsa051680.61511166
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59108890
73Salivary secretion_Homo sapiens_hsa049700.58766286
74Primary immunodeficiency_Homo sapiens_hsa053400.56931276
75Ether lipid metabolism_Homo sapiens_hsa005650.56068830
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55109539
77Olfactory transduction_Homo sapiens_hsa047400.54475223
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53621391
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52213007
80Glycerolipid metabolism_Homo sapiens_hsa005610.50322852
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49851069
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49711988
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.45285234
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45267605
85Ovarian steroidogenesis_Homo sapiens_hsa049130.44499693
86Metabolic pathways_Homo sapiens_hsa011000.43345810
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.42054874
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39235179
89Arginine and proline metabolism_Homo sapiens_hsa003300.35822005
90Galactose metabolism_Homo sapiens_hsa000520.35183859
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33698255
92Tyrosine metabolism_Homo sapiens_hsa003500.33314200
93Hematopoietic cell lineage_Homo sapiens_hsa046400.33217127
94Fat digestion and absorption_Homo sapiens_hsa049750.33150887
95Nicotine addiction_Homo sapiens_hsa050330.29520043
96Taste transduction_Homo sapiens_hsa047420.26774526
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.21950794
98Collecting duct acid secretion_Homo sapiens_hsa049660.20698070
99Carbon metabolism_Homo sapiens_hsa012000.20498887
100Starch and sucrose metabolism_Homo sapiens_hsa005000.20245612

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