Rank | Gene Set | Z-score |
---|---|---|
1 | chaperone-mediated protein transport (GO:0072321) | 9.58196208 |
2 | ribosomal small subunit biogenesis (GO:0042274) | 8.08224379 |
3 | nucleoside transmembrane transport (GO:1901642) | 7.95001770 |
4 | GDP-mannose metabolic process (GO:0019673) | 7.26855042 |
5 | mannose metabolic process (GO:0006013) | 7.09104665 |
6 | maturation of 5.8S rRNA (GO:0000460) | 6.52082918 |
7 | RNA localization (GO:0006403) | 6.38567476 |
8 | viral transcription (GO:0019083) | 6.32702562 |
9 | translational termination (GO:0006415) | 6.03732066 |
10 | nucleoside transport (GO:0015858) | 5.94491738 |
11 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 5.81679513 |
12 | positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517) | 5.77930712 |
13 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 5.65136038 |
14 | ribosomal small subunit assembly (GO:0000028) | 5.59399994 |
15 | translational elongation (GO:0006414) | 5.29092722 |
16 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.20436531 |
17 | cotranslational protein targeting to membrane (GO:0006613) | 5.12832642 |
18 | protein targeting to ER (GO:0045047) | 5.09812744 |
19 | signal complex assembly (GO:0007172) | 5.01940906 |
20 | cytochrome complex assembly (GO:0017004) | 4.98870383 |
21 | ATP synthesis coupled proton transport (GO:0015986) | 4.93139912 |
22 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.93139912 |
23 | megakaryocyte development (GO:0035855) | 4.89303631 |
24 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.83724957 |
25 | pyrimidine nucleotide catabolic process (GO:0006244) | 4.83022684 |
26 | DNA deamination (GO:0045006) | 4.79775206 |
27 | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 4.79178673 |
28 | protein localization to endoplasmic reticulum (GO:0070972) | 4.75171314 |
29 | positive regulation of translational initiation (GO:0045948) | 4.73161929 |
30 | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254) | 4.57109770 |
31 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.53755228 |
32 | interferon-gamma production (GO:0032609) | 4.53555666 |
33 | regulation of mitochondrial translation (GO:0070129) | 4.48343357 |
34 | positive regulation of signal transduction by p53 class mediator (GO:1901798) | 4.47338616 |
35 | cellular protein complex disassembly (GO:0043624) | 4.42874059 |
36 | viral life cycle (GO:0019058) | 4.37683030 |
37 | protein complex biogenesis (GO:0070271) | 4.34529933 |
38 | cofactor transport (GO:0051181) | 4.34264862 |
39 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.31437781 |
40 | pseudouridine synthesis (GO:0001522) | 4.23000222 |
41 | reproduction (GO:0000003) | 4.18762601 |
42 | translational initiation (GO:0006413) | 4.17666848 |
43 | cellular component biogenesis (GO:0044085) | 4.12952952 |
44 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 4.07760102 |
45 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 4.07760102 |
46 | translation (GO:0006412) | 4.05919705 |
47 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 4.04555638 |
48 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.02817742 |
49 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.99417945 |
50 | peroxisome fission (GO:0016559) | 3.98033686 |
51 | secretory granule organization (GO:0033363) | 3.96068342 |
52 | regulation of mitochondrial membrane potential (GO:0051881) | 3.87236960 |
53 | regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253) | 3.70067820 |
54 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.66800043 |
55 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.56834406 |
56 | protein targeting to membrane (GO:0006612) | 3.56328900 |
57 | intracellular protein transmembrane import (GO:0044743) | 3.54080515 |
58 | protein complex disassembly (GO:0043241) | 3.51872164 |
59 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.49376730 |
60 | respiratory chain complex IV assembly (GO:0008535) | 3.32603662 |
61 | modified amino acid transport (GO:0072337) | 3.32005878 |
62 | aerobic respiration (GO:0009060) | 3.30584570 |
63 | negative regulation of signal transduction by p53 class mediator (GO:1901797) | 3.28793782 |
64 | piRNA metabolic process (GO:0034587) | 3.24662380 |
65 | macromolecular complex disassembly (GO:0032984) | 3.22397291 |
66 | base-excision repair, AP site formation (GO:0006285) | 3.21425463 |
67 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.20240604 |
68 | outer ear morphogenesis (GO:0042473) | 3.20019361 |
69 | regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516) | 3.16502678 |
70 | maturation of SSU-rRNA (GO:0030490) | 3.14791430 |
71 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.13255927 |
72 | regulation of icosanoid secretion (GO:0032303) | 3.11892090 |
73 | ATP biosynthetic process (GO:0006754) | 3.11151566 |
74 | respiratory electron transport chain (GO:0022904) | 3.10443566 |
75 | deoxyribonucleotide catabolic process (GO:0009264) | 3.09121197 |
76 | ribosomal large subunit biogenesis (GO:0042273) | 3.07888933 |
77 | mitochondrion morphogenesis (GO:0070584) | 3.06683117 |
78 | electron transport chain (GO:0022900) | 3.04837459 |
79 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.02527740 |
80 | T cell apoptotic process (GO:0070231) | 3.02211790 |
81 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.01225793 |
82 | positive regulation of icosanoid secretion (GO:0032305) | 2.99176718 |
83 | platelet formation (GO:0030220) | 2.98589783 |
84 | mRNA catabolic process (GO:0006402) | 2.97698692 |
85 | negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665) | 2.97071064 |
86 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.94958187 |
87 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.94958187 |
88 | NADH dehydrogenase complex assembly (GO:0010257) | 2.94958187 |
89 | positive regulation of fatty acid transport (GO:2000193) | 2.90187100 |
90 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.89897154 |
91 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.88158081 |
92 | regulation of memory T cell differentiation (GO:0043380) | 2.85815940 |
93 | cellular response to estradiol stimulus (GO:0071392) | 2.85253130 |
94 | deoxyribose phosphate catabolic process (GO:0046386) | 2.84375102 |
95 | positive regulation of protein kinase C signaling (GO:0090037) | 2.81785058 |
96 | short-chain fatty acid metabolic process (GO:0046459) | 2.79999550 |
97 | signal peptide processing (GO:0006465) | 2.77833400 |
98 | negative regulation of membrane potential (GO:0045837) | 2.76692277 |
99 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.76510932 |
100 | GTP biosynthetic process (GO:0006183) | 2.75218956 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 6.17253082 |
2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.21417241 |
3 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 4.77965130 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.05084251 |
5 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.96092396 |
6 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 2.95197841 |
7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.87380930 |
8 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.81666900 |
9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.73840676 |
10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.63082173 |
11 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.57071869 |
12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.37199794 |
13 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.33171359 |
14 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.24011948 |
15 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.12531993 |
16 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.09998443 |
17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.01930536 |
18 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.96816024 |
19 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.82354753 |
20 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.81784434 |
21 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.81672128 |
22 | VDR_22108803_ChIP-Seq_LS180_Human | 1.81077306 |
23 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.79487132 |
24 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.71472657 |
25 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.68575540 |
26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.67389681 |
27 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.64730614 |
28 | EGR1_19032775_ChIP-ChIP_M12_Human | 1.63678047 |
29 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.62405350 |
30 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.61970582 |
31 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.59043136 |
32 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.53971803 |
33 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.46706404 |
34 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.42226695 |
35 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.41300065 |
36 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.39559587 |
37 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.38442027 |
38 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.37098444 |
39 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.35394332 |
40 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.34990248 |
41 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.34385735 |
42 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.33907355 |
43 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.30150122 |
44 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.29631455 |
45 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.28244120 |
46 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.26533986 |
47 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.25898110 |
48 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.25723026 |
49 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25652368 |
50 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.24828991 |
51 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.22775655 |
52 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.20123466 |
53 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.19058458 |
54 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.18437212 |
55 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 1.18031177 |
56 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.17956244 |
57 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.16075320 |
58 | NCOR_22424771_ChIP-Seq_293T_Human | 1.14363187 |
59 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.13544265 |
60 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.13382650 |
61 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.13163949 |
62 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.12988753 |
63 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.12821177 |
64 | SA1_27219007_Chip-Seq_Bcells_Human | 1.09548277 |
65 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.08875800 |
66 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.07927689 |
67 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 1.07716141 |
68 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.06873403 |
69 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.06616044 |
70 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.06605855 |
71 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.05849571 |
72 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 1.05100638 |
73 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.04686466 |
74 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.04642981 |
75 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.04628927 |
76 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.04009504 |
77 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.02774604 |
78 | NFYA_21822215_ChIP-Seq_K562_Human | 1.02505105 |
79 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 1.02036188 |
80 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.00889928 |
81 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.00057121 |
82 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.00057121 |
83 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.99728151 |
84 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.99693189 |
85 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.99578052 |
86 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.98805613 |
87 | NFYB_21822215_ChIP-Seq_K562_Human | 0.98075000 |
88 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.97610027 |
89 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.97502406 |
90 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.96607692 |
91 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.95358495 |
92 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.94931259 |
93 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.94920698 |
94 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.94087289 |
95 | ERA_21632823_ChIP-Seq_H3396_Human | 0.93896380 |
96 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.92990805 |
97 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.92220927 |
98 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.91755964 |
99 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.91380098 |
100 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.90269050 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003646_muscle_fatigue | 4.99362278 |
2 | MP0002638_abnormal_pupillary_reflex | 4.63381488 |
3 | MP0009379_abnormal_foot_pigmentation | 2.80185684 |
4 | MP0001727_abnormal_embryo_implantation | 2.66723131 |
5 | MP0006072_abnormal_retinal_apoptosis | 2.59973471 |
6 | MP0005671_abnormal_response_to | 2.57380806 |
7 | MP0004043_abnormal_pH_regulation | 2.44908149 |
8 | MP0003195_calcinosis | 2.39469197 |
9 | MP0002277_abnormal_respiratory_mucosa | 2.27346776 |
10 | MP0004885_abnormal_endolymph | 2.26242167 |
11 | MP0003878_abnormal_ear_physiology | 2.22541306 |
12 | MP0005377_hearing/vestibular/ear_phenot | 2.22541306 |
13 | MP0004145_abnormal_muscle_electrophysio | 2.19855801 |
14 | MP0001348_abnormal_lacrimal_gland | 2.12960829 |
15 | MP0005503_abnormal_tendon_morphology | 2.11910647 |
16 | MP0006292_abnormal_olfactory_placode | 2.08377224 |
17 | MP0003436_decreased_susceptibility_to | 2.05842510 |
18 | MP0002837_dystrophic_cardiac_calcinosis | 1.94115059 |
19 | MP0002163_abnormal_gland_morphology | 1.93797787 |
20 | MP0002876_abnormal_thyroid_physiology | 1.91907210 |
21 | MP0002160_abnormal_reproductive_system | 1.90122608 |
22 | MP0005174_abnormal_tail_pigmentation | 1.86310675 |
23 | MP0008875_abnormal_xenobiotic_pharmacok | 1.86126608 |
24 | MP0004147_increased_porphyrin_level | 1.79504340 |
25 | MP0001790_abnormal_immune_system | 1.77910382 |
26 | MP0005387_immune_system_phenotype | 1.77910382 |
27 | MP0002148_abnormal_hypersensitivity_rea | 1.73474481 |
28 | MP0002736_abnormal_nociception_after | 1.66699554 |
29 | MP0006035_abnormal_mitochondrial_morpho | 1.58762788 |
30 | MP0005379_endocrine/exocrine_gland_phen | 1.58345592 |
31 | MP0001501_abnormal_sleep_pattern | 1.53211103 |
32 | MP0005253_abnormal_eye_physiology | 1.53100760 |
33 | MP0005389_reproductive_system_phenotype | 1.48622011 |
34 | MP0004130_abnormal_muscle_cell | 1.47825396 |
35 | MP0001968_abnormal_touch/_nociception | 1.47216828 |
36 | MP0001188_hyperpigmentation | 1.47188920 |
37 | MP0001661_extended_life_span | 1.47069302 |
38 | MP0001835_abnormal_antigen_presentation | 1.46779454 |
39 | MP0009333_abnormal_splenocyte_physiolog | 1.45834638 |
40 | MP0009764_decreased_sensitivity_to | 1.45586347 |
41 | MP0003011_delayed_dark_adaptation | 1.43505111 |
42 | MP0005410_abnormal_fertilization | 1.40122448 |
43 | MP0004133_heterotaxia | 1.34873292 |
44 | MP0002102_abnormal_ear_morphology | 1.34628395 |
45 | MP0004142_abnormal_muscle_tone | 1.28053283 |
46 | MP0001986_abnormal_taste_sensitivity | 1.26023721 |
47 | MP0005084_abnormal_gallbladder_morpholo | 1.25625720 |
48 | MP0001873_stomach_inflammation | 1.25419967 |
49 | MP0009785_altered_susceptibility_to | 1.24428418 |
50 | MP0008872_abnormal_physiological_respon | 1.21280625 |
51 | MP0002938_white_spotting | 1.19375408 |
52 | MP0004858_abnormal_nervous_system | 1.18137111 |
53 | MP0005000_abnormal_immune_tolerance | 1.17440189 |
54 | MP0008775_abnormal_heart_ventricle | 1.14379969 |
55 | MP0009250_abnormal_appendicular_skeleto | 1.12760994 |
56 | MP0006036_abnormal_mitochondrial_physio | 1.12026511 |
57 | MP0001800_abnormal_humoral_immune | 1.08397509 |
58 | MP0005646_abnormal_pituitary_gland | 1.08036738 |
59 | MP0005332_abnormal_amino_acid | 1.07226573 |
60 | MP0005551_abnormal_eye_electrophysiolog | 1.00514117 |
61 | MP0001533_abnormal_skeleton_physiology | 1.00103089 |
62 | MP0002933_joint_inflammation | 0.96170801 |
63 | MP0002095_abnormal_skin_pigmentation | 0.95850494 |
64 | MP0008260_abnormal_autophagy | 0.92591826 |
65 | MP0002723_abnormal_immune_serum | 0.91002260 |
66 | MP0001529_abnormal_vocalization | 0.90933146 |
67 | MP0001881_abnormal_mammary_gland | 0.90205711 |
68 | MP0001485_abnormal_pinna_reflex | 0.89189341 |
69 | MP0001905_abnormal_dopamine_level | 0.88441623 |
70 | MP0006082_CNS_inflammation | 0.87793600 |
71 | MP0000685_abnormal_immune_system | 0.87286736 |
72 | MP0001542_abnormal_bone_strength | 0.87193313 |
73 | MP0001502_abnormal_circadian_rhythm | 0.85940737 |
74 | MP0000372_irregular_coat_pigmentation | 0.85547476 |
75 | MP0006276_abnormal_autonomic_nervous | 0.82967601 |
76 | MP0000343_altered_response_to | 0.82486774 |
77 | MP0009745_abnormal_behavioral_response | 0.81934084 |
78 | MP0002971_abnormal_brown_adipose | 0.81236460 |
79 | MP0002234_abnormal_pharynx_morphology | 0.80358959 |
80 | MP0002557_abnormal_social/conspecific_i | 0.79983581 |
81 | MP0004215_abnormal_myocardial_fiber | 0.79942802 |
82 | MP0003786_premature_aging | 0.78367070 |
83 | MP0000579_abnormal_nail_morphology | 0.76630658 |
84 | MP0004742_abnormal_vestibular_system | 0.72535157 |
85 | MP0002210_abnormal_sex_determination | 0.72139875 |
86 | MP0000049_abnormal_middle_ear | 0.71551046 |
87 | MP0005195_abnormal_posterior_eye | 0.69320025 |
88 | MP0003879_abnormal_hair_cell | 0.68825329 |
89 | MP0005025_abnormal_response_to | 0.68716861 |
90 | MP0001663_abnormal_digestive_system | 0.68261597 |
91 | MP0005636_abnormal_mineral_homeostasis | 0.68171365 |
92 | MP0008995_early_reproductive_senescence | 0.66623526 |
93 | MP0001919_abnormal_reproductive_system | 0.65238585 |
94 | MP0004957_abnormal_blastocyst_morpholog | 0.64995162 |
95 | MP0000462_abnormal_digestive_system | 0.64548297 |
96 | MP0009765_abnormal_xenobiotic_induced | 0.63963660 |
97 | MP0001119_abnormal_female_reproductive | 0.63456188 |
98 | MP0001819_abnormal_immune_cell | 0.63420875 |
99 | MP0002420_abnormal_adaptive_immunity | 0.62963354 |
100 | MP0010155_abnormal_intestine_physiology | 0.62802977 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Global brain atrophy (HP:0002283) | 5.10690878 |
2 | Hypobetalipoproteinemia (HP:0003563) | 5.03637134 |
3 | Methylmalonic acidemia (HP:0002912) | 4.11594157 |
4 | Acanthocytosis (HP:0001927) | 3.90752905 |
5 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 3.71777494 |
6 | Increased hepatocellular lipid droplets (HP:0006565) | 3.68118245 |
7 | Patent foramen ovale (HP:0001655) | 3.67839986 |
8 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.58032679 |
9 | Renal Fanconi syndrome (HP:0001994) | 3.48599489 |
10 | Dyskinesia (HP:0100660) | 3.46769186 |
11 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.45459394 |
12 | Hyperglycinemia (HP:0002154) | 3.44439326 |
13 | Agitation (HP:0000713) | 3.38234803 |
14 | Neurodegeneration (HP:0002180) | 3.30843548 |
15 | Lipid accumulation in hepatocytes (HP:0006561) | 3.23961325 |
16 | Broad distal phalanx of finger (HP:0009836) | 3.23741219 |
17 | Macrocytic anemia (HP:0001972) | 3.16419519 |
18 | Increased CSF lactate (HP:0002490) | 3.15922570 |
19 | Mitochondrial inheritance (HP:0001427) | 3.02844449 |
20 | Microretrognathia (HP:0000308) | 2.93343235 |
21 | 3-Methylglutaconic aciduria (HP:0003535) | 2.91943787 |
22 | Akinesia (HP:0002304) | 2.90927894 |
23 | Methylmalonic aciduria (HP:0012120) | 2.89901173 |
24 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.85661400 |
25 | Abnormality of alanine metabolism (HP:0010916) | 2.85661400 |
26 | Hyperalaninemia (HP:0003348) | 2.85661400 |
27 | Congenital stationary night blindness (HP:0007642) | 2.76110545 |
28 | Acute necrotizing encephalopathy (HP:0006965) | 2.69980490 |
29 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.67492744 |
30 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.65812292 |
31 | Abnormal number of erythroid precursors (HP:0012131) | 2.65529612 |
32 | CNS demyelination (HP:0007305) | 2.64853077 |
33 | Restlessness (HP:0000711) | 2.62611169 |
34 | Increased intramyocellular lipid droplets (HP:0012240) | 2.61074430 |
35 | Pallor (HP:0000980) | 2.55755458 |
36 | Renal tubular dysfunction (HP:0000124) | 2.55216224 |
37 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.54658237 |
38 | Dysphonia (HP:0001618) | 2.50824898 |
39 | Exertional dyspnea (HP:0002875) | 2.50295680 |
40 | Cerebral hypomyelination (HP:0006808) | 2.50010301 |
41 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.48165803 |
42 | Partial duplication of the phalanx of hand (HP:0009999) | 2.47935665 |
43 | Abnormality of vitamin B metabolism (HP:0004340) | 2.42513730 |
44 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.37476365 |
45 | Orchitis (HP:0100796) | 2.35878131 |
46 | Abnormality of midbrain morphology (HP:0002418) | 2.34077508 |
47 | Molar tooth sign on MRI (HP:0002419) | 2.34077508 |
48 | Abnormality of the 2nd finger (HP:0004100) | 2.32138968 |
49 | Delayed CNS myelination (HP:0002188) | 2.29838701 |
50 | Progressive macrocephaly (HP:0004481) | 2.29556115 |
51 | Hepatocellular necrosis (HP:0001404) | 2.26464760 |
52 | Tubulointerstitial nephritis (HP:0001970) | 2.25275882 |
53 | Increased serum lactate (HP:0002151) | 2.21047923 |
54 | Hepatic necrosis (HP:0002605) | 2.19923965 |
55 | Ketosis (HP:0001946) | 2.19864755 |
56 | Reticulocytopenia (HP:0001896) | 2.18617311 |
57 | Progressive muscle weakness (HP:0003323) | 2.16886688 |
58 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.16143681 |
59 | Concave nail (HP:0001598) | 2.13990556 |
60 | Acute encephalopathy (HP:0006846) | 2.13317808 |
61 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.12811197 |
62 | Renal cortical cysts (HP:0000803) | 2.11597354 |
63 | Increased muscle lipid content (HP:0009058) | 2.10746616 |
64 | Respiratory difficulties (HP:0002880) | 2.10148731 |
65 | Abnormality of the pons (HP:0007361) | 2.09425197 |
66 | Hypoplasia of the pons (HP:0012110) | 2.09419766 |
67 | Brushfield spots (HP:0001088) | 2.08953897 |
68 | Hypolipoproteinemia (HP:0010981) | 2.08512165 |
69 | Decreased muscle mass (HP:0003199) | 2.07577931 |
70 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.03490441 |
71 | Abnormality of renal resorption (HP:0011038) | 2.02850895 |
72 | Hemiplegia (HP:0002301) | 2.02489100 |
73 | Asplenia (HP:0001746) | 2.00167886 |
74 | Abnormality of the renal cortex (HP:0011035) | 2.00015066 |
75 | Lethargy (HP:0001254) | 1.98086079 |
76 | Abnormality of the basal ganglia (HP:0002134) | 1.97538919 |
77 | Myositis (HP:0100614) | 1.96508345 |
78 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.95441572 |
79 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.94619149 |
80 | Diminished movement (HP:0002374) | 1.92125918 |
81 | Lactic acidosis (HP:0003128) | 1.91931241 |
82 | Glycosuria (HP:0003076) | 1.91147500 |
83 | Abnormality of urine glucose concentration (HP:0011016) | 1.91147500 |
84 | Carpal bone hypoplasia (HP:0001498) | 1.89543774 |
85 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.88415587 |
86 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.85749735 |
87 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.84515358 |
88 | Abnormality of serum amino acid levels (HP:0003112) | 1.84307714 |
89 | Cerebral edema (HP:0002181) | 1.83303049 |
90 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.83262054 |
91 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.83262054 |
92 | Personality changes (HP:0000751) | 1.81924846 |
93 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 1.81110341 |
94 | Absent thumb (HP:0009777) | 1.80773258 |
95 | Amblyopia (HP:0000646) | 1.79677818 |
96 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.79251363 |
97 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.76046238 |
98 | Absent/shortened dynein arms (HP:0200106) | 1.76046238 |
99 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.74190571 |
100 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.74190571 |
Rank | Gene Set | Z-score |
---|---|---|
1 | RIPK1 | 8.37400841 |
2 | PDK2 | 3.39449321 |
3 | ERN1 | 3.06617590 |
4 | PRKCI | 3.05259311 |
5 | BMPR2 | 2.68139418 |
6 | MAP4K1 | 2.65276641 |
7 | TXK | 2.58907518 |
8 | STK16 | 2.52404526 |
9 | BCKDK | 2.39275793 |
10 | MAP4K2 | 2.28449418 |
11 | NME2 | 2.28046007 |
12 | MAP2K6 | 2.15360417 |
13 | PASK | 1.98119835 |
14 | GRK1 | 1.94477971 |
15 | PDPK1 | 1.91410309 |
16 | WNK4 | 1.90861125 |
17 | PRKCG | 1.82897185 |
18 | ADRBK2 | 1.71445458 |
19 | TIE1 | 1.71234926 |
20 | ZAK | 1.66117615 |
21 | FRK | 1.62543126 |
22 | NEK1 | 1.55239826 |
23 | YES1 | 1.23099085 |
24 | TLK1 | 1.21992213 |
25 | PRKCE | 1.14302739 |
26 | LCK | 1.12904745 |
27 | STK38 | 1.12149960 |
28 | WNK3 | 1.08746155 |
29 | NUAK1 | 1.05512886 |
30 | PRKCD | 1.04803425 |
31 | IKBKB | 0.97470855 |
32 | KIT | 0.96408835 |
33 | STK4 | 0.92026604 |
34 | DAPK3 | 0.90437608 |
35 | MAPKAPK3 | 0.87270527 |
36 | AKT2 | 0.85874097 |
37 | INSRR | 0.85300928 |
38 | MATK | 0.81040899 |
39 | STK3 | 0.79089057 |
40 | PRKCZ | 0.76797467 |
41 | SYK | 0.76056901 |
42 | OBSCN | 0.73810405 |
43 | STK38L | 0.72638483 |
44 | NME1 | 0.72396041 |
45 | FES | 0.72169518 |
46 | GRK6 | 0.71785383 |
47 | TEC | 0.69709844 |
48 | ADRBK1 | 0.69000677 |
49 | TAOK3 | 0.68366706 |
50 | CSNK2A2 | 0.66238233 |
51 | CSNK2A1 | 0.66188527 |
52 | BMPR1B | 0.66001695 |
53 | PINK1 | 0.62948888 |
54 | PKN1 | 0.61854102 |
55 | EIF2AK3 | 0.61663826 |
56 | OXSR1 | 0.59740497 |
57 | KDR | 0.59685008 |
58 | ABL2 | 0.58608986 |
59 | PRKCQ | 0.58159305 |
60 | STK39 | 0.56664871 |
61 | TRIM28 | 0.55763544 |
62 | BUB1 | 0.55727146 |
63 | ITK | 0.55238408 |
64 | BTK | 0.54469212 |
65 | PIM1 | 0.52714442 |
66 | PIK3CG | 0.49813829 |
67 | RPS6KB2 | 0.49167266 |
68 | MAPK15 | 0.47230927 |
69 | MAP2K2 | 0.46208496 |
70 | FYN | 0.45354170 |
71 | PRKCA | 0.44863924 |
72 | PLK4 | 0.44662845 |
73 | TGFBR1 | 0.43845682 |
74 | CSK | 0.42648948 |
75 | STK24 | 0.41363621 |
76 | PRKCB | 0.40702067 |
77 | PRKCH | 0.36375083 |
78 | BRAF | 0.35781342 |
79 | RPS6KB1 | 0.33021624 |
80 | PTK2B | 0.31963761 |
81 | CAMK2A | 0.31368005 |
82 | INSR | 0.31359783 |
83 | IGF1R | 0.31150928 |
84 | ATR | 0.30916742 |
85 | MUSK | 0.30388209 |
86 | PRKACA | 0.30102807 |
87 | CSNK1A1 | 0.28686770 |
88 | MAP2K4 | 0.28553525 |
89 | RIPK4 | 0.27795976 |
90 | PDK1 | 0.26937205 |
91 | IKBKE | 0.25310210 |
92 | RPS6KA6 | 0.24033465 |
93 | GRK7 | 0.23988520 |
94 | PIK3CA | 0.23680443 |
95 | CDK4 | 0.23470823 |
96 | LYN | 0.23365414 |
97 | PIM2 | 0.21852686 |
98 | ILK | 0.21784142 |
99 | FLT3 | 0.21442757 |
100 | PHKG2 | 0.21277110 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 6.35290818 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.51565768 |
3 | Parkinsons disease_Homo sapiens_hsa05012 | 2.96621459 |
4 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.88964797 |
5 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.77547812 |
6 | Tyrosine metabolism_Homo sapiens_hsa00350 | 2.46016953 |
7 | RNA degradation_Homo sapiens_hsa03018 | 2.19709052 |
8 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 2.16387144 |
9 | Alzheimers disease_Homo sapiens_hsa05010 | 1.96693261 |
10 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.96003659 |
11 | Huntingtons disease_Homo sapiens_hsa05016 | 1.89873761 |
12 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.89787454 |
13 | Protein export_Homo sapiens_hsa03060 | 1.89655437 |
14 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.83094391 |
15 | Sulfur relay system_Homo sapiens_hsa04122 | 1.78950173 |
16 | RNA polymerase_Homo sapiens_hsa03020 | 1.77283047 |
17 | Proteasome_Homo sapiens_hsa03050 | 1.66964751 |
18 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.63597571 |
19 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.61944548 |
20 | Asthma_Homo sapiens_hsa05310 | 1.61060490 |
21 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.53938360 |
22 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.52581795 |
23 | Allograft rejection_Homo sapiens_hsa05330 | 1.50096953 |
24 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.41317125 |
25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.39853420 |
26 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.35936588 |
27 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.28040974 |
28 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.23440853 |
29 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.21167048 |
30 | Peroxisome_Homo sapiens_hsa04146 | 1.16421722 |
31 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.14547979 |
32 | Phototransduction_Homo sapiens_hsa04744 | 1.09961152 |
33 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.08314379 |
34 | Olfactory transduction_Homo sapiens_hsa04740 | 1.07046867 |
35 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.03828448 |
36 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.99631242 |
37 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.99123588 |
38 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.98654366 |
39 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.96085771 |
40 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.95007934 |
41 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.92981691 |
42 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.92735833 |
43 | Purine metabolism_Homo sapiens_hsa00230 | 0.92257604 |
44 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.90774228 |
45 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.89222187 |
46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.88523106 |
47 | DNA replication_Homo sapiens_hsa03030 | 0.85506357 |
48 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.84450337 |
49 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.81789831 |
50 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.80924412 |
51 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.78920892 |
52 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.75245912 |
53 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.74970270 |
54 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.73438346 |
55 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.72426734 |
56 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.70540145 |
57 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.69511762 |
58 | Base excision repair_Homo sapiens_hsa03410 | 0.68852225 |
59 | Homologous recombination_Homo sapiens_hsa03440 | 0.68660010 |
60 | Lysine degradation_Homo sapiens_hsa00310 | 0.68434537 |
61 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67931349 |
62 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.66855591 |
63 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.66346378 |
64 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.65145101 |
65 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.62670239 |
66 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.60769025 |
67 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.60225255 |
68 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.57616989 |
69 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.57560658 |
70 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.56244655 |
71 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.56184921 |
72 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.54866671 |
73 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.53965547 |
74 | Retinol metabolism_Homo sapiens_hsa00830 | 0.53386171 |
75 | Mismatch repair_Homo sapiens_hsa03430 | 0.53168127 |
76 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.51866502 |
77 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.51494121 |
78 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.49572465 |
79 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.49004748 |
80 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.48815693 |
81 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.46532749 |
82 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.46524410 |
83 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.46395031 |
84 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.45015272 |
85 | Spliceosome_Homo sapiens_hsa03040 | 0.44505507 |
86 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.43850359 |
87 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.42431132 |
88 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.41586432 |
89 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.39861287 |
90 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.38187960 |
91 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.37002158 |
92 | RNA transport_Homo sapiens_hsa03013 | 0.34717989 |
93 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.33867483 |
94 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.31077104 |
95 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.29817530 |
96 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.27267554 |
97 | Morphine addiction_Homo sapiens_hsa05032 | 0.27183790 |
98 | Malaria_Homo sapiens_hsa05144 | 0.26500427 |
99 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.24385266 |
100 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.24265279 |