RPS6P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)9.58196208
2ribosomal small subunit biogenesis (GO:0042274)8.08224379
3nucleoside transmembrane transport (GO:1901642)7.95001770
4GDP-mannose metabolic process (GO:0019673)7.26855042
5mannose metabolic process (GO:0006013)7.09104665
6maturation of 5.8S rRNA (GO:0000460)6.52082918
7RNA localization (GO:0006403)6.38567476
8viral transcription (GO:0019083)6.32702562
9translational termination (GO:0006415)6.03732066
10nucleoside transport (GO:0015858)5.94491738
11negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 5.81679513
12positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)5.77930712
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.65136038
14ribosomal small subunit assembly (GO:0000028)5.59399994
15translational elongation (GO:0006414)5.29092722
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.20436531
17cotranslational protein targeting to membrane (GO:0006613)5.12832642
18protein targeting to ER (GO:0045047)5.09812744
19signal complex assembly (GO:0007172)5.01940906
20cytochrome complex assembly (GO:0017004)4.98870383
21ATP synthesis coupled proton transport (GO:0015986)4.93139912
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.93139912
23megakaryocyte development (GO:0035855)4.89303631
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.83724957
25pyrimidine nucleotide catabolic process (GO:0006244)4.83022684
26DNA deamination (GO:0045006)4.79775206
27regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.79178673
28protein localization to endoplasmic reticulum (GO:0070972)4.75171314
29positive regulation of translational initiation (GO:0045948)4.73161929
30negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)4.57109770
31establishment of protein localization to mitochondrial membrane (GO:0090151)4.53755228
32interferon-gamma production (GO:0032609)4.53555666
33regulation of mitochondrial translation (GO:0070129)4.48343357
34positive regulation of signal transduction by p53 class mediator (GO:1901798)4.47338616
35cellular protein complex disassembly (GO:0043624)4.42874059
36viral life cycle (GO:0019058)4.37683030
37protein complex biogenesis (GO:0070271)4.34529933
38cofactor transport (GO:0051181)4.34264862
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.31437781
40pseudouridine synthesis (GO:0001522)4.23000222
41reproduction (GO:0000003)4.18762601
42translational initiation (GO:0006413)4.17666848
43cellular component biogenesis (GO:0044085)4.12952952
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.07760102
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.07760102
46translation (GO:0006412)4.05919705
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.04555638
48mitochondrial respiratory chain complex assembly (GO:0033108)4.02817742
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.99417945
50peroxisome fission (GO:0016559)3.98033686
51secretory granule organization (GO:0033363)3.96068342
52regulation of mitochondrial membrane potential (GO:0051881)3.87236960
53regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.70067820
54water-soluble vitamin biosynthetic process (GO:0042364)3.66800043
55pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.56834406
56protein targeting to membrane (GO:0006612)3.56328900
57intracellular protein transmembrane import (GO:0044743)3.54080515
58protein complex disassembly (GO:0043241)3.51872164
59ribonucleoprotein complex biogenesis (GO:0022613)3.49376730
60respiratory chain complex IV assembly (GO:0008535)3.32603662
61modified amino acid transport (GO:0072337)3.32005878
62aerobic respiration (GO:0009060)3.30584570
63negative regulation of signal transduction by p53 class mediator (GO:1901797)3.28793782
64piRNA metabolic process (GO:0034587)3.24662380
65macromolecular complex disassembly (GO:0032984)3.22397291
66base-excision repair, AP site formation (GO:0006285)3.21425463
67nuclear-transcribed mRNA catabolic process (GO:0000956)3.20240604
68outer ear morphogenesis (GO:0042473)3.20019361
69regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)3.16502678
70maturation of SSU-rRNA (GO:0030490)3.14791430
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13255927
72regulation of icosanoid secretion (GO:0032303)3.11892090
73ATP biosynthetic process (GO:0006754)3.11151566
74respiratory electron transport chain (GO:0022904)3.10443566
75deoxyribonucleotide catabolic process (GO:0009264)3.09121197
76ribosomal large subunit biogenesis (GO:0042273)3.07888933
77mitochondrion morphogenesis (GO:0070584)3.06683117
78electron transport chain (GO:0022900)3.04837459
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02527740
80T cell apoptotic process (GO:0070231)3.02211790
81purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01225793
82positive regulation of icosanoid secretion (GO:0032305)2.99176718
83platelet formation (GO:0030220)2.98589783
84mRNA catabolic process (GO:0006402)2.97698692
85negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.97071064
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94958187
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.94958187
88NADH dehydrogenase complex assembly (GO:0010257)2.94958187
89positive regulation of fatty acid transport (GO:2000193)2.90187100
90mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89897154
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.88158081
92regulation of memory T cell differentiation (GO:0043380)2.85815940
93cellular response to estradiol stimulus (GO:0071392)2.85253130
94deoxyribose phosphate catabolic process (GO:0046386)2.84375102
95positive regulation of protein kinase C signaling (GO:0090037)2.81785058
96short-chain fatty acid metabolic process (GO:0046459)2.79999550
97signal peptide processing (GO:0006465)2.77833400
98negative regulation of membrane potential (GO:0045837)2.76692277
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76510932
100GTP biosynthetic process (GO:0006183)2.75218956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.17253082
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.21417241
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.77965130
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.05084251
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96092396
6SRY_22984422_ChIP-ChIP_TESTIS_Rat2.95197841
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87380930
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.81666900
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.73840676
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.63082173
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.57071869
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37199794
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33171359
14YY1_21170310_ChIP-Seq_MESCs_Mouse2.24011948
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12531993
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.09998443
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01930536
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.96816024
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82354753
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.81784434
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81672128
22VDR_22108803_ChIP-Seq_LS180_Human1.81077306
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79487132
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.71472657
25GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.68575540
26FOXP3_21729870_ChIP-Seq_TREG_Human1.67389681
27RNF2_27304074_Chip-Seq_NSC_Mouse1.64730614
28EGR1_19032775_ChIP-ChIP_M12_Human1.63678047
29VDR_23849224_ChIP-Seq_CD4+_Human1.62405350
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.61970582
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59043136
32KDM5A_27292631_Chip-Seq_BREAST_Human1.53971803
33EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.46706404
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42226695
35NANOG_20526341_ChIP-Seq_ESCs_Human1.41300065
36GATA6_21074721_ChIP-Seq_CACO-2_Human1.39559587
37MYC_18940864_ChIP-ChIP_HL60_Human1.38442027
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37098444
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35394332
40ZNF274_21170338_ChIP-Seq_K562_Hela1.34990248
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34385735
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33907355
43ETV1_20927104_ChIP-Seq_GIST48_Human1.30150122
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29631455
45RBPJ_21746931_ChIP-Seq_IB4_Human1.28244120
46XRN2_22483619_ChIP-Seq_HELA_Human1.26533986
47PHF8_20622853_ChIP-Seq_HELA_Human1.25898110
48IRF1_19129219_ChIP-ChIP_H3396_Human1.25723026
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25652368
50FOXH1_21741376_ChIP-Seq_ESCs_Human1.24828991
51TAF2_19829295_ChIP-Seq_ESCs_Human1.22775655
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20123466
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19058458
54DCP1A_22483619_ChIP-Seq_HELA_Human1.18437212
55PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18031177
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17956244
57CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.16075320
58NCOR_22424771_ChIP-Seq_293T_Human1.14363187
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13544265
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13382650
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13163949
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12988753
63YY1_22570637_ChIP-Seq_MALME-3M_Human1.12821177
64SA1_27219007_Chip-Seq_Bcells_Human1.09548277
65AR_21572438_ChIP-Seq_LNCaP_Human1.08875800
66MYC_19829295_ChIP-Seq_ESCs_Human1.07927689
67BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.07716141
68ELK1_19687146_ChIP-ChIP_HELA_Human1.06873403
69TTF2_22483619_ChIP-Seq_HELA_Human1.06616044
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06605855
71RUNX_20019798_ChIP-Seq_JUKART_Human1.05849571
72SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.05100638
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.04686466
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04642981
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04628927
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04009504
77CBX2_22325352_ChIP-Seq_293T-Rex_Human1.02774604
78NFYA_21822215_ChIP-Seq_K562_Human1.02505105
79STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02036188
80STAT1_20625510_ChIP-Seq_HELA_Human1.00889928
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.00057121
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00057121
83SOX2_21211035_ChIP-Seq_LN229_Human0.99728151
84IRF8_22096565_ChIP-ChIP_GC-B_Human0.99693189
85OCT4_20526341_ChIP-Seq_ESCs_Human0.99578052
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98805613
87NFYB_21822215_ChIP-Seq_K562_Human0.98075000
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97610027
89E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97502406
90E2F1_20622854_ChIP-Seq_HELA_Human0.96607692
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95358495
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94931259
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94920698
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94087289
95ERA_21632823_ChIP-Seq_H3396_Human0.93896380
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92990805
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92220927
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91755964
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91380098
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.90269050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.99362278
2MP0002638_abnormal_pupillary_reflex4.63381488
3MP0009379_abnormal_foot_pigmentation2.80185684
4MP0001727_abnormal_embryo_implantation2.66723131
5MP0006072_abnormal_retinal_apoptosis2.59973471
6MP0005671_abnormal_response_to2.57380806
7MP0004043_abnormal_pH_regulation2.44908149
8MP0003195_calcinosis2.39469197
9MP0002277_abnormal_respiratory_mucosa2.27346776
10MP0004885_abnormal_endolymph2.26242167
11MP0003878_abnormal_ear_physiology2.22541306
12MP0005377_hearing/vestibular/ear_phenot2.22541306
13MP0004145_abnormal_muscle_electrophysio2.19855801
14MP0001348_abnormal_lacrimal_gland2.12960829
15MP0005503_abnormal_tendon_morphology2.11910647
16MP0006292_abnormal_olfactory_placode2.08377224
17MP0003436_decreased_susceptibility_to2.05842510
18MP0002837_dystrophic_cardiac_calcinosis1.94115059
19MP0002163_abnormal_gland_morphology1.93797787
20MP0002876_abnormal_thyroid_physiology1.91907210
21MP0002160_abnormal_reproductive_system1.90122608
22MP0005174_abnormal_tail_pigmentation1.86310675
23MP0008875_abnormal_xenobiotic_pharmacok1.86126608
24MP0004147_increased_porphyrin_level1.79504340
25MP0001790_abnormal_immune_system1.77910382
26MP0005387_immune_system_phenotype1.77910382
27MP0002148_abnormal_hypersensitivity_rea1.73474481
28MP0002736_abnormal_nociception_after1.66699554
29MP0006035_abnormal_mitochondrial_morpho1.58762788
30MP0005379_endocrine/exocrine_gland_phen1.58345592
31MP0001501_abnormal_sleep_pattern1.53211103
32MP0005253_abnormal_eye_physiology1.53100760
33MP0005389_reproductive_system_phenotype1.48622011
34MP0004130_abnormal_muscle_cell1.47825396
35MP0001968_abnormal_touch/_nociception1.47216828
36MP0001188_hyperpigmentation1.47188920
37MP0001661_extended_life_span1.47069302
38MP0001835_abnormal_antigen_presentation1.46779454
39MP0009333_abnormal_splenocyte_physiolog1.45834638
40MP0009764_decreased_sensitivity_to1.45586347
41MP0003011_delayed_dark_adaptation1.43505111
42MP0005410_abnormal_fertilization1.40122448
43MP0004133_heterotaxia1.34873292
44MP0002102_abnormal_ear_morphology1.34628395
45MP0004142_abnormal_muscle_tone1.28053283
46MP0001986_abnormal_taste_sensitivity1.26023721
47MP0005084_abnormal_gallbladder_morpholo1.25625720
48MP0001873_stomach_inflammation1.25419967
49MP0009785_altered_susceptibility_to1.24428418
50MP0008872_abnormal_physiological_respon1.21280625
51MP0002938_white_spotting1.19375408
52MP0004858_abnormal_nervous_system1.18137111
53MP0005000_abnormal_immune_tolerance1.17440189
54MP0008775_abnormal_heart_ventricle1.14379969
55MP0009250_abnormal_appendicular_skeleto1.12760994
56MP0006036_abnormal_mitochondrial_physio1.12026511
57MP0001800_abnormal_humoral_immune1.08397509
58MP0005646_abnormal_pituitary_gland1.08036738
59MP0005332_abnormal_amino_acid1.07226573
60MP0005551_abnormal_eye_electrophysiolog1.00514117
61MP0001533_abnormal_skeleton_physiology1.00103089
62MP0002933_joint_inflammation0.96170801
63MP0002095_abnormal_skin_pigmentation0.95850494
64MP0008260_abnormal_autophagy0.92591826
65MP0002723_abnormal_immune_serum0.91002260
66MP0001529_abnormal_vocalization0.90933146
67MP0001881_abnormal_mammary_gland0.90205711
68MP0001485_abnormal_pinna_reflex0.89189341
69MP0001905_abnormal_dopamine_level0.88441623
70MP0006082_CNS_inflammation0.87793600
71MP0000685_abnormal_immune_system0.87286736
72MP0001542_abnormal_bone_strength0.87193313
73MP0001502_abnormal_circadian_rhythm0.85940737
74MP0000372_irregular_coat_pigmentation0.85547476
75MP0006276_abnormal_autonomic_nervous0.82967601
76MP0000343_altered_response_to0.82486774
77MP0009745_abnormal_behavioral_response0.81934084
78MP0002971_abnormal_brown_adipose0.81236460
79MP0002234_abnormal_pharynx_morphology0.80358959
80MP0002557_abnormal_social/conspecific_i0.79983581
81MP0004215_abnormal_myocardial_fiber0.79942802
82MP0003786_premature_aging0.78367070
83MP0000579_abnormal_nail_morphology0.76630658
84MP0004742_abnormal_vestibular_system0.72535157
85MP0002210_abnormal_sex_determination0.72139875
86MP0000049_abnormal_middle_ear0.71551046
87MP0005195_abnormal_posterior_eye0.69320025
88MP0003879_abnormal_hair_cell0.68825329
89MP0005025_abnormal_response_to0.68716861
90MP0001663_abnormal_digestive_system0.68261597
91MP0005636_abnormal_mineral_homeostasis0.68171365
92MP0008995_early_reproductive_senescence0.66623526
93MP0001919_abnormal_reproductive_system0.65238585
94MP0004957_abnormal_blastocyst_morpholog0.64995162
95MP0000462_abnormal_digestive_system0.64548297
96MP0009765_abnormal_xenobiotic_induced0.63963660
97MP0001119_abnormal_female_reproductive0.63456188
98MP0001819_abnormal_immune_cell0.63420875
99MP0002420_abnormal_adaptive_immunity0.62963354
100MP0010155_abnormal_intestine_physiology0.62802977

Predicted human phenotypes

RankGene SetZ-score
1Global brain atrophy (HP:0002283)5.10690878
2Hypobetalipoproteinemia (HP:0003563)5.03637134
3Methylmalonic acidemia (HP:0002912)4.11594157
4Acanthocytosis (HP:0001927)3.90752905
5Abnormality of the phalanges of the 2nd finger (HP:0009541)3.71777494
6Increased hepatocellular lipid droplets (HP:0006565)3.68118245
7Patent foramen ovale (HP:0001655)3.67839986
8Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.58032679
9Renal Fanconi syndrome (HP:0001994)3.48599489
10Dyskinesia (HP:0100660)3.46769186
11Abnormality of cells of the erythroid lineage (HP:0012130)3.45459394
12Hyperglycinemia (HP:0002154)3.44439326
13Agitation (HP:0000713)3.38234803
14Neurodegeneration (HP:0002180)3.30843548
15Lipid accumulation in hepatocytes (HP:0006561)3.23961325
16Broad distal phalanx of finger (HP:0009836)3.23741219
17Macrocytic anemia (HP:0001972)3.16419519
18Increased CSF lactate (HP:0002490)3.15922570
19Mitochondrial inheritance (HP:0001427)3.02844449
20Microretrognathia (HP:0000308)2.93343235
213-Methylglutaconic aciduria (HP:0003535)2.91943787
22Akinesia (HP:0002304)2.90927894
23Methylmalonic aciduria (HP:0012120)2.89901173
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85661400
25Abnormality of alanine metabolism (HP:0010916)2.85661400
26Hyperalaninemia (HP:0003348)2.85661400
27Congenital stationary night blindness (HP:0007642)2.76110545
28Acute necrotizing encephalopathy (HP:0006965)2.69980490
29Elevated erythrocyte sedimentation rate (HP:0003565)2.67492744
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65812292
31Abnormal number of erythroid precursors (HP:0012131)2.65529612
32CNS demyelination (HP:0007305)2.64853077
33Restlessness (HP:0000711)2.62611169
34Increased intramyocellular lipid droplets (HP:0012240)2.61074430
35Pallor (HP:0000980)2.55755458
36Renal tubular dysfunction (HP:0000124)2.55216224
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54658237
38Dysphonia (HP:0001618)2.50824898
39Exertional dyspnea (HP:0002875)2.50295680
40Cerebral hypomyelination (HP:0006808)2.50010301
41Abnormality of the vitamin B12 metabolism (HP:0004341)2.48165803
42Partial duplication of the phalanx of hand (HP:0009999)2.47935665
43Abnormality of vitamin B metabolism (HP:0004340)2.42513730
44Abnormal mitochondria in muscle tissue (HP:0008316)2.37476365
45Orchitis (HP:0100796)2.35878131
46Abnormality of midbrain morphology (HP:0002418)2.34077508
47Molar tooth sign on MRI (HP:0002419)2.34077508
48Abnormality of the 2nd finger (HP:0004100)2.32138968
49Delayed CNS myelination (HP:0002188)2.29838701
50Progressive macrocephaly (HP:0004481)2.29556115
51Hepatocellular necrosis (HP:0001404)2.26464760
52Tubulointerstitial nephritis (HP:0001970)2.25275882
53Increased serum lactate (HP:0002151)2.21047923
54Hepatic necrosis (HP:0002605)2.19923965
55Ketosis (HP:0001946)2.19864755
56Reticulocytopenia (HP:0001896)2.18617311
57Progressive muscle weakness (HP:0003323)2.16886688
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16143681
59Concave nail (HP:0001598)2.13990556
60Acute encephalopathy (HP:0006846)2.13317808
61Abnormality of fatty-acid metabolism (HP:0004359)2.12811197
62Renal cortical cysts (HP:0000803)2.11597354
63Increased muscle lipid content (HP:0009058)2.10746616
64Respiratory difficulties (HP:0002880)2.10148731
65Abnormality of the pons (HP:0007361)2.09425197
66Hypoplasia of the pons (HP:0012110)2.09419766
67Brushfield spots (HP:0001088)2.08953897
68Hypolipoproteinemia (HP:0010981)2.08512165
69Decreased muscle mass (HP:0003199)2.07577931
70Abnormal rod and cone electroretinograms (HP:0008323)2.03490441
71Abnormality of renal resorption (HP:0011038)2.02850895
72Hemiplegia (HP:0002301)2.02489100
73Asplenia (HP:0001746)2.00167886
74Abnormality of the renal cortex (HP:0011035)2.00015066
75Lethargy (HP:0001254)1.98086079
76Abnormality of the basal ganglia (HP:0002134)1.97538919
77Myositis (HP:0100614)1.96508345
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.95441572
79Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.94619149
80Diminished movement (HP:0002374)1.92125918
81Lactic acidosis (HP:0003128)1.91931241
82Glycosuria (HP:0003076)1.91147500
83Abnormality of urine glucose concentration (HP:0011016)1.91147500
84Carpal bone hypoplasia (HP:0001498)1.89543774
85Abnormality of the phalanges of the 5th finger (HP:0004213)1.88415587
86Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.85749735
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84515358
88Abnormality of serum amino acid levels (HP:0003112)1.84307714
89Cerebral edema (HP:0002181)1.83303049
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83262054
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83262054
92Personality changes (HP:0000751)1.81924846
93Symphalangism affecting the phalanges of the hand (HP:0009773)1.81110341
94Absent thumb (HP:0009777)1.80773258
95Amblyopia (HP:0000646)1.79677818
96Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.79251363
97Dynein arm defect of respiratory motile cilia (HP:0012255)1.76046238
98Absent/shortened dynein arms (HP:0200106)1.76046238
99Abnormal respiratory motile cilium morphology (HP:0005938)1.74190571
100Abnormal respiratory epithelium morphology (HP:0012253)1.74190571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK18.37400841
2PDK23.39449321
3ERN13.06617590
4PRKCI3.05259311
5BMPR22.68139418
6MAP4K12.65276641
7TXK2.58907518
8STK162.52404526
9BCKDK2.39275793
10MAP4K22.28449418
11NME22.28046007
12MAP2K62.15360417
13PASK1.98119835
14GRK11.94477971
15PDPK11.91410309
16WNK41.90861125
17PRKCG1.82897185
18ADRBK21.71445458
19TIE11.71234926
20ZAK1.66117615
21FRK1.62543126
22NEK11.55239826
23YES11.23099085
24TLK11.21992213
25PRKCE1.14302739
26LCK1.12904745
27STK381.12149960
28WNK31.08746155
29NUAK11.05512886
30PRKCD1.04803425
31IKBKB0.97470855
32KIT0.96408835
33STK40.92026604
34DAPK30.90437608
35MAPKAPK30.87270527
36AKT20.85874097
37INSRR0.85300928
38MATK0.81040899
39STK30.79089057
40PRKCZ0.76797467
41SYK0.76056901
42OBSCN0.73810405
43STK38L0.72638483
44NME10.72396041
45FES0.72169518
46GRK60.71785383
47TEC0.69709844
48ADRBK10.69000677
49TAOK30.68366706
50CSNK2A20.66238233
51CSNK2A10.66188527
52BMPR1B0.66001695
53PINK10.62948888
54PKN10.61854102
55EIF2AK30.61663826
56OXSR10.59740497
57KDR0.59685008
58ABL20.58608986
59PRKCQ0.58159305
60STK390.56664871
61TRIM280.55763544
62BUB10.55727146
63ITK0.55238408
64BTK0.54469212
65PIM10.52714442
66PIK3CG0.49813829
67RPS6KB20.49167266
68MAPK150.47230927
69MAP2K20.46208496
70FYN0.45354170
71PRKCA0.44863924
72PLK40.44662845
73TGFBR10.43845682
74CSK0.42648948
75STK240.41363621
76PRKCB0.40702067
77PRKCH0.36375083
78BRAF0.35781342
79RPS6KB10.33021624
80PTK2B0.31963761
81CAMK2A0.31368005
82INSR0.31359783
83IGF1R0.31150928
84ATR0.30916742
85MUSK0.30388209
86PRKACA0.30102807
87CSNK1A10.28686770
88MAP2K40.28553525
89RIPK40.27795976
90PDK10.26937205
91IKBKE0.25310210
92RPS6KA60.24033465
93GRK70.23988520
94PIK3CA0.23680443
95CDK40.23470823
96LYN0.23365414
97PIM20.21852686
98ILK0.21784142
99FLT30.21442757
100PHKG20.21277110

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.35290818
2Oxidative phosphorylation_Homo sapiens_hsa001903.51565768
3Parkinsons disease_Homo sapiens_hsa050122.96621459
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.88964797
5Sulfur metabolism_Homo sapiens_hsa009202.77547812
6Tyrosine metabolism_Homo sapiens_hsa003502.46016953
7RNA degradation_Homo sapiens_hsa030182.19709052
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.16387144
9Alzheimers disease_Homo sapiens_hsa050101.96693261
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96003659
11Huntingtons disease_Homo sapiens_hsa050161.89873761
12Cardiac muscle contraction_Homo sapiens_hsa042601.89787454
13Protein export_Homo sapiens_hsa030601.89655437
14Graft-versus-host disease_Homo sapiens_hsa053321.83094391
15Sulfur relay system_Homo sapiens_hsa041221.78950173
16RNA polymerase_Homo sapiens_hsa030201.77283047
17Proteasome_Homo sapiens_hsa030501.66964751
18Linoleic acid metabolism_Homo sapiens_hsa005911.63597571
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61944548
20Asthma_Homo sapiens_hsa053101.61060490
21Regulation of autophagy_Homo sapiens_hsa041401.53938360
22Autoimmune thyroid disease_Homo sapiens_hsa053201.52581795
23Allograft rejection_Homo sapiens_hsa053301.50096953
24Caffeine metabolism_Homo sapiens_hsa002321.41317125
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39853420
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35936588
27Tryptophan metabolism_Homo sapiens_hsa003801.28040974
28Pyrimidine metabolism_Homo sapiens_hsa002401.23440853
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.21167048
30Peroxisome_Homo sapiens_hsa041461.16421722
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14547979
32Phototransduction_Homo sapiens_hsa047441.09961152
33Type I diabetes mellitus_Homo sapiens_hsa049401.08314379
34Olfactory transduction_Homo sapiens_hsa047401.07046867
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03828448
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99631242
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99123588
38Fructose and mannose metabolism_Homo sapiens_hsa000510.98654366
39One carbon pool by folate_Homo sapiens_hsa006700.96085771
40Nitrogen metabolism_Homo sapiens_hsa009100.95007934
41Selenocompound metabolism_Homo sapiens_hsa004500.92981691
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.92735833
43Purine metabolism_Homo sapiens_hsa002300.92257604
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90774228
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89222187
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88523106
47DNA replication_Homo sapiens_hsa030300.85506357
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84450337
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.81789831
50Arachidonic acid metabolism_Homo sapiens_hsa005900.80924412
51Fat digestion and absorption_Homo sapiens_hsa049750.78920892
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75245912
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74970270
54Folate biosynthesis_Homo sapiens_hsa007900.73438346
55Propanoate metabolism_Homo sapiens_hsa006400.72426734
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70540145
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69511762
58Base excision repair_Homo sapiens_hsa034100.68852225
59Homologous recombination_Homo sapiens_hsa034400.68660010
60Lysine degradation_Homo sapiens_hsa003100.68434537
61Metabolic pathways_Homo sapiens_hsa011000.67931349
62Primary immunodeficiency_Homo sapiens_hsa053400.66855591
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66346378
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65145101
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62670239
66Fanconi anemia pathway_Homo sapiens_hsa034600.60769025
67Antigen processing and presentation_Homo sapiens_hsa046120.60225255
68Butanoate metabolism_Homo sapiens_hsa006500.57616989
69Rheumatoid arthritis_Homo sapiens_hsa053230.57560658
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.56244655
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56184921
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54866671
73Ether lipid metabolism_Homo sapiens_hsa005650.53965547
74Retinol metabolism_Homo sapiens_hsa008300.53386171
75Mismatch repair_Homo sapiens_hsa034300.53168127
76Chemical carcinogenesis_Homo sapiens_hsa052040.51866502
77Hematopoietic cell lineage_Homo sapiens_hsa046400.51494121
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.49572465
79T cell receptor signaling pathway_Homo sapiens_hsa046600.49004748
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48815693
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46532749
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46524410
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46395031
84Collecting duct acid secretion_Homo sapiens_hsa049660.45015272
85Spliceosome_Homo sapiens_hsa030400.44505507
86Glutathione metabolism_Homo sapiens_hsa004800.43850359
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42431132
88Fatty acid metabolism_Homo sapiens_hsa012120.41586432
89Vitamin B6 metabolism_Homo sapiens_hsa007500.39861287
90Fatty acid degradation_Homo sapiens_hsa000710.38187960
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37002158
92RNA transport_Homo sapiens_hsa030130.34717989
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33867483
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.31077104
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29817530
96beta-Alanine metabolism_Homo sapiens_hsa004100.27267554
97Morphine addiction_Homo sapiens_hsa050320.27183790
98Malaria_Homo sapiens_hsa051440.26500427
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24385266
100Vitamin digestion and absorption_Homo sapiens_hsa049770.24265279

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