RPS6P21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)7.85908206
2sperm motility (GO:0030317)7.57646250
3fusion of sperm to egg plasma membrane (GO:0007342)6.84703913
4response to pheromone (GO:0019236)6.73908395
5multicellular organism reproduction (GO:0032504)6.21990371
6rRNA methylation (GO:0031167)5.90511928
7spermatid development (GO:0007286)5.52261615
8sperm-egg recognition (GO:0035036)5.37327162
9calcium ion-dependent exocytosis (GO:0017156)5.35447323
10rRNA modification (GO:0000154)5.31284846
11sperm capacitation (GO:0048240)5.29131432
12piRNA metabolic process (GO:0034587)5.24683551
13protein polyglutamylation (GO:0018095)5.23893982
14reproduction (GO:0000003)5.17505627
15plasma membrane fusion (GO:0045026)5.15581160
16response to lipoprotein particle (GO:0055094)5.06396575
17single strand break repair (GO:0000012)4.97444115
18DNA deamination (GO:0045006)4.85384650
19chromosome condensation (GO:0030261)4.79519658
20DNA packaging (GO:0006323)4.77860038
21microtubule depolymerization (GO:0007019)4.76509142
22binding of sperm to zona pellucida (GO:0007339)4.76003360
23glycerol ether metabolic process (GO:0006662)4.69606889
24regulation of transcription involved in cell fate commitment (GO:0060850)4.58139100
25DNA methylation involved in gamete generation (GO:0043046)4.49752809
26cell-cell recognition (GO:0009988)4.45860729
27negative regulation of telomerase activity (GO:0051974)4.44531262
28ether metabolic process (GO:0018904)4.32156197
29spermatogenesis (GO:0007283)4.31026131
30male gamete generation (GO:0048232)4.30368804
31microtubule severing (GO:0051013)4.19752776
32negative regulation of acute inflammatory response (GO:0002674)4.19712452
33protein targeting to Golgi (GO:0000042)4.09028618
34phosphatidylethanolamine biosynthetic process (GO:0006646)4.08593098
35gamete generation (GO:0007276)4.04646554
36spermatid nucleus differentiation (GO:0007289)3.99035232
37cellular ketone body metabolic process (GO:0046950)3.94075869
38centriole replication (GO:0007099)3.93608117
39axonemal dynein complex assembly (GO:0070286)3.92426494
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.92404245
41NADH dehydrogenase complex assembly (GO:0010257)3.92404245
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92404245
43establishment of protein localization to Golgi (GO:0072600)3.91595779
44synapsis (GO:0007129)3.80735368
45microtubule polymerization or depolymerization (GO:0031109)3.80426735
46branching involved in labyrinthine layer morphogenesis (GO:0060670)3.79908867
47RNA destabilization (GO:0050779)3.79601917
48retrograde transport, vesicle recycling within Golgi (GO:0000301)3.79299284
49phosphatidylethanolamine metabolic process (GO:0046337)3.69236285
50single fertilization (GO:0007338)3.67147302
51positive regulation of glomerulus development (GO:0090193)3.66539283
52somite development (GO:0061053)3.61783253
53regulation of telomerase activity (GO:0051972)3.57035200
54ketone body metabolic process (GO:1902224)3.44035697
55germ cell development (GO:0007281)3.42842015
56endoderm formation (GO:0001706)3.41809018
57protein localization to Golgi apparatus (GO:0034067)3.30335302
58regulation of meiosis I (GO:0060631)3.29436348
59negative regulation of Rho protein signal transduction (GO:0035024)3.28114673
60regulation of centriole replication (GO:0046599)3.26222562
61centriole assembly (GO:0098534)3.24316270
62response to caffeine (GO:0031000)3.23769950
63male meiosis I (GO:0007141)3.23725033
64regulation of receptor binding (GO:1900120)3.23357418
65centrosome duplication (GO:0051298)3.21050493
66fertilization (GO:0009566)3.17680386
67multicellular organismal reproductive process (GO:0048609)3.17650536
68positive regulation of oligodendrocyte differentiation (GO:0048714)3.13114538
69sexual reproduction (GO:0019953)3.13035213
70epithelial cilium movement (GO:0003351)3.12262314
71protein complex biogenesis (GO:0070271)3.11089693
72cellular response to lithium ion (GO:0071285)3.10799486
73cell wall macromolecule catabolic process (GO:0016998)3.05713548
74mitochondrial fusion (GO:0008053)2.99987271
75embryonic skeletal joint morphogenesis (GO:0060272)2.98806973
76pharyngeal system development (GO:0060037)2.94593799
77regulation of female gonad development (GO:2000194)2.93748667
78negative regulation of cardiac muscle tissue growth (GO:0055022)2.93459731
79negative regulation of heart growth (GO:0061117)2.93459731
80meiotic cell cycle (GO:0051321)2.93100820
81cellular process involved in reproduction in multicellular organism (GO:0022412)2.91922125
82male meiosis (GO:0007140)2.91896098
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89055156
84positive regulation of gastrulation (GO:2000543)2.88717796
85coenzyme catabolic process (GO:0009109)2.87775264
86motile cilium assembly (GO:0044458)2.87016507
87mitochondrial respiratory chain complex assembly (GO:0033108)2.86465077
88serine family amino acid catabolic process (GO:0009071)2.86090235
89cell wall macromolecule metabolic process (GO:0044036)2.83782284
90regulation of mesoderm development (GO:2000380)2.83735180
91limb development (GO:0060173)2.81337129
92appendage development (GO:0048736)2.81337129
93spindle assembly involved in mitosis (GO:0090307)2.79887906
94positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.79573034
95negative regulation of cardiac muscle tissue development (GO:0055026)2.78298045
96positive regulation of fatty acid oxidation (GO:0046321)2.76848142
97cilium or flagellum-dependent cell motility (GO:0001539)2.75753043
98regulation of cilium movement (GO:0003352)2.74906893
99negative regulation of inclusion body assembly (GO:0090084)2.74464722
100seminiferous tubule development (GO:0072520)2.72390409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.48065148
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.23488502
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.91552024
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.66901101
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26978715
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41601430
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26884719
8ZNF274_21170338_ChIP-Seq_K562_Hela2.15476126
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10473479
10EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.09137654
11TDRD3_21172665_ChIP-Seq_MCF-7_Human2.09135755
12VDR_22108803_ChIP-Seq_LS180_Human2.04811604
13FUS_26573619_Chip-Seq_HEK293_Human2.02728255
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94644198
15AUTS2_25519132_ChIP-Seq_293T-REX_Human1.91101942
16ER_23166858_ChIP-Seq_MCF-7_Human1.86740213
17GBX2_23144817_ChIP-Seq_PC3_Human1.84080151
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79610561
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68461529
20CBP_20019798_ChIP-Seq_JUKART_Human1.68461529
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67214120
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66836821
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65936241
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.64286647
25NANOG_20526341_ChIP-Seq_ESCs_Human1.63829467
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63307145
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62683847
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.62150685
29EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.57252000
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.50298788
31ERA_21632823_ChIP-Seq_H3396_Human1.48451588
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47187217
33RAC3_21632823_ChIP-Seq_H3396_Human1.43704302
34YY1_22570637_ChIP-Seq_MALME-3M_Human1.40612846
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40276352
36TAF15_26573619_Chip-Seq_HEK293_Human1.37781343
37TAF2_19829295_ChIP-Seq_ESCs_Human1.36563722
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.35696518
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35337023
40IRF1_19129219_ChIP-ChIP_H3396_Human1.35312663
41MYC_19829295_ChIP-Seq_ESCs_Human1.32562072
42AR_25329375_ChIP-Seq_VCAP_Human1.31691454
43P300_19829295_ChIP-Seq_ESCs_Human1.31413695
44KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30559128
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30181441
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29646790
47CTCF_20526341_ChIP-Seq_ESCs_Human1.28191181
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.27065462
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26833354
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.26457550
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.25441871
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.25305736
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.24568843
54NANOG_19829295_ChIP-Seq_ESCs_Human1.24221009
55SOX2_19829295_ChIP-Seq_ESCs_Human1.24221009
56DROSHA_22980978_ChIP-Seq_HELA_Human1.24215610
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24023846
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22607990
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21960762
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21073895
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21073895
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20405745
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.19706241
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.18388662
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18388662
66MYC_18940864_ChIP-ChIP_HL60_Human1.18148449
67BCL6_27268052_Chip-Seq_Bcells_Human1.15464351
68RUNX2_22187159_ChIP-Seq_PCA_Human1.14705303
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.14413119
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.12908709
71RUNX_20019798_ChIP-Seq_JUKART_Human1.10635894
72TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09980562
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09563624
74P300_27268052_Chip-Seq_Bcells_Human1.09329749
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.08974771
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08606686
77LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08512261
78SMAD4_21799915_ChIP-Seq_A2780_Human1.07498359
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07460237
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.07104623
81SMAD3_21741376_ChIP-Seq_ESCs_Human1.06403694
82ERG_20517297_ChIP-Seq_VCAP_Human1.06284071
83GATA3_26560356_Chip-Seq_TH1_Human1.05397629
84RBPJ_21746931_ChIP-Seq_IB4_Human1.04757872
85E2F1_20622854_ChIP-Seq_HELA_Human1.02349892
86SMRT_27268052_Chip-Seq_Bcells_Human1.02041715
87HOXB7_26014856_ChIP-Seq_BT474_Human1.00768061
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00628712
89SOX2_21211035_ChIP-Seq_LN229_Human0.99744630
90ETV1_20927104_ChIP-Seq_GIST48_Human0.99223934
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98892611
92NCOR_22424771_ChIP-Seq_293T_Human0.98810041
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.97524509
94TCF4_23295773_ChIP-Seq_U87_Human0.97429020
95STAT3_23295773_ChIP-Seq_U87_Human0.97270808
96CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95949353
97P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.94676002
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94552131
99HNFA_21074721_ChIP-Seq_CACO-2_Human0.94481457
100AHR_22903824_ChIP-Seq_MCF-7_Human0.93231917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.75085314
2MP0005670_abnormal_white_adipose6.54100846
3MP0006292_abnormal_olfactory_placode2.95109857
4MP0003724_increased_susceptibility_to2.87863389
5MP0002138_abnormal_hepatobiliary_system2.79931856
6MP0003718_maternal_effect2.78919807
7MP0005646_abnormal_pituitary_gland2.71196672
8MP0001485_abnormal_pinna_reflex2.51962821
9MP0000049_abnormal_middle_ear2.51961016
10MP0008877_abnormal_DNA_methylation2.51482634
11MP0003698_abnormal_male_reproductive2.49459556
12MP0009053_abnormal_anal_canal2.45325277
13MP0003878_abnormal_ear_physiology2.44310654
14MP0005377_hearing/vestibular/ear_phenot2.44310654
15MP0000013_abnormal_adipose_tissue2.43662275
16MP0001929_abnormal_gametogenesis2.42691822
17MP0000678_abnormal_parathyroid_gland2.11647781
18MP0003693_abnormal_embryo_hatching2.02164491
19MP0001348_abnormal_lacrimal_gland1.91666889
20MP0000516_abnormal_urinary_system1.78354605
21MP0005367_renal/urinary_system_phenotyp1.78354605
22MP0002234_abnormal_pharynx_morphology1.75474873
23MP0002282_abnormal_trachea_morphology1.72721687
24MP0003119_abnormal_digestive_system1.70342073
25MP0002210_abnormal_sex_determination1.65573083
26MP0002161_abnormal_fertility/fecundity1.53212832
27MP0005551_abnormal_eye_electrophysiolog1.43894678
28MP0002160_abnormal_reproductive_system1.43290132
29MP0001835_abnormal_antigen_presentation1.42645305
30MP0008872_abnormal_physiological_respon1.40994967
31MP0003646_muscle_fatigue1.40838155
32MP0003011_delayed_dark_adaptation1.35375488
33MP0001963_abnormal_hearing_physiology1.31125024
34MP0002653_abnormal_ependyma_morphology1.30843115
35MP0001145_abnormal_male_reproductive1.26652570
36MP0003879_abnormal_hair_cell1.26546931
37MP0000653_abnormal_sex_gland1.25796172
38MP0001968_abnormal_touch/_nociception1.24479534
39MP0003283_abnormal_digestive_organ1.21516155
40MP0005379_endocrine/exocrine_gland_phen1.19370973
41MP0002272_abnormal_nervous_system1.17765059
42MP0008789_abnormal_olfactory_epithelium1.17149656
43MP0003936_abnormal_reproductive_system1.15884147
44MP0005310_abnormal_salivary_gland1.15160195
45MP0009765_abnormal_xenobiotic_induced1.14795653
46MP0002249_abnormal_larynx_morphology1.12637979
47MP0002102_abnormal_ear_morphology1.11851719
48MP0004142_abnormal_muscle_tone1.10512877
49MP0001440_abnormal_grooming_behavior1.09574863
50MP0001661_extended_life_span1.06435729
51MP0005423_abnormal_somatic_nervous1.01231072
52MP0006072_abnormal_retinal_apoptosis0.99774981
53MP0001765_abnormal_ion_homeostasis0.98066774
54MP0005389_reproductive_system_phenotype0.95685054
55MP0005253_abnormal_eye_physiology0.94340194
56MP0009379_abnormal_foot_pigmentation0.93341342
57MP0002735_abnormal_chemical_nociception0.92820641
58MP0000467_abnormal_esophagus_morphology0.92676104
59MP0000026_abnormal_inner_ear0.92642563
60MP0002139_abnormal_hepatobiliary_system0.90616687
61MP0000534_abnormal_ureter_morphology0.90539116
62MP0000631_abnormal_neuroendocrine_gland0.90275266
63MP0001486_abnormal_startle_reflex0.89953277
64MP0004185_abnormal_adipocyte_glucose0.87809462
65MP0003699_abnormal_female_reproductive0.87229578
66MP0001986_abnormal_taste_sensitivity0.82787934
67MP0003315_abnormal_perineum_morphology0.82199993
68MP0002229_neurodegeneration0.82083658
69MP0003937_abnormal_limbs/digits/tail_de0.80515358
70MP0009745_abnormal_behavioral_response0.77862354
71MP0002163_abnormal_gland_morphology0.76316833
72MP0005360_urolithiasis0.75008344
73MP0001905_abnormal_dopamine_level0.74323621
74MP0005645_abnormal_hypothalamus_physiol0.74310628
75MP0000003_abnormal_adipose_tissue0.73543880
76MP0002751_abnormal_autonomic_nervous0.72511930
77MP0003938_abnormal_ear_development0.72204186
78MP0005084_abnormal_gallbladder_morpholo0.71868819
79MP0003890_abnormal_embryonic-extraembry0.68539319
80MP0001984_abnormal_olfaction0.67367607
81MP0001119_abnormal_female_reproductive0.67309294
82MP0004742_abnormal_vestibular_system0.67222862
83MP0005499_abnormal_olfactory_system0.66566180
84MP0005394_taste/olfaction_phenotype0.66566180
85MP0000372_irregular_coat_pigmentation0.66424890
86MP0002277_abnormal_respiratory_mucosa0.65789494
87MP0004130_abnormal_muscle_cell0.65635785
88MP0000537_abnormal_urethra_morphology0.62452248
89MP0001800_abnormal_humoral_immune0.62376729
90MP0009115_abnormal_fat_cell0.62101051
91MP0002557_abnormal_social/conspecific_i0.62050615
92MP0005076_abnormal_cell_differentiation0.61110584
93MP0000230_abnormal_systemic_arterial0.61044685
94MP0002572_abnormal_emotion/affect_behav0.60846879
95MP0003635_abnormal_synaptic_transmissio0.59647652
96MP0003880_abnormal_central_pattern0.57688982
97MP0003638_abnormal_response/metabolism_0.57241125
98MP0006036_abnormal_mitochondrial_physio0.56420603
99MP0005195_abnormal_posterior_eye0.55580574
100MP0005671_abnormal_response_to0.55006328

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.38062779
2Short 1st metacarpal (HP:0010034)5.38062779
3Abnormality of the 1st metacarpal (HP:0010009)4.74143733
4Fused cervical vertebrae (HP:0002949)4.15083644
5Short phalanx of the thumb (HP:0009660)3.96213656
6Stenosis of the external auditory canal (HP:0000402)3.93114656
7Severe visual impairment (HP:0001141)3.78817718
8Ectopic kidney (HP:0000086)3.67832725
9Abnormality of the nasal septum (HP:0000419)3.53033065
10Hypoalphalipoproteinemia (HP:0003233)3.48884359
11Bony spicule pigmentary retinopathy (HP:0007737)3.43622805
12Oligomenorrhea (HP:0000876)3.37096831
13Absent/shortened dynein arms (HP:0200106)3.34534937
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.34534937
15Insulin-resistant diabetes mellitus (HP:0000831)3.30364558
16Synostosis of carpal bones (HP:0005048)3.17116638
17Pendular nystagmus (HP:0012043)3.14694295
18Increased purine levels (HP:0004368)3.14020395
19Hyperuricemia (HP:0002149)3.14020395
20Maternal diabetes (HP:0009800)3.10386849
21Absent thumb (HP:0009777)3.08685136
22Attenuation of retinal blood vessels (HP:0007843)3.01044006
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98113782
24Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.95472122
25Carpal bone hypoplasia (HP:0001498)2.94795109
26Congenital sensorineural hearing impairment (HP:0008527)2.89153519
27Chromsome breakage (HP:0040012)2.87933904
28Decreased subcutaneous fat (HP:0001002)2.84389572
29Short hallux (HP:0010109)2.84232756
30Aplasia/Hypoplasia involving the musculature (HP:0001460)2.83921570
31Abnormality of the proximal phalanges of the hand (HP:0009834)2.78989332
32Abnormal ciliary motility (HP:0012262)2.74323687
33Abnormal rod and cone electroretinograms (HP:0008323)2.74259082
34Abnormality of the carotid arteries (HP:0005344)2.67323418
35Abnormality of DNA repair (HP:0003254)2.64574302
36Abnormality of the costochondral junction (HP:0000919)2.62361798
37Aplasia/Hypoplasia of the hallux (HP:0008362)2.59146915
38Abnormality of the renal collecting system (HP:0004742)2.55999949
39Osteomalacia (HP:0002749)2.54598182
40Abnormal respiratory motile cilium morphology (HP:0005938)2.54138720
41Abnormal respiratory epithelium morphology (HP:0012253)2.54138720
42Toxemia of pregnancy (HP:0100603)2.51233799
43Abnormal respiratory motile cilium physiology (HP:0012261)2.49557848
44Short humerus (HP:0005792)2.49033167
45Nephronophthisis (HP:0000090)2.48992157
46Aplasia/hypoplasia of the humerus (HP:0006507)2.47046783
47Morphological abnormality of the middle ear (HP:0008609)2.44670210
48Stomatitis (HP:0010280)2.43962000
49Acute necrotizing encephalopathy (HP:0006965)2.38860098
50Short thumb (HP:0009778)2.38582814
51Type II lissencephaly (HP:0007260)2.37730230
52Rectal fistula (HP:0100590)2.36887565
53Rectovaginal fistula (HP:0000143)2.36887565
54Chronic hepatic failure (HP:0100626)2.35534440
55Reticulocytopenia (HP:0001896)2.31696286
56Congenital stationary night blindness (HP:0007642)2.29971999
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.27012925
58Vertebral fusion (HP:0002948)2.22739039
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.20567542
60Abolished electroretinogram (ERG) (HP:0000550)2.20296574
61Azoospermia (HP:0000027)2.19514606
62Horseshoe kidney (HP:0000085)2.18983376
63Infertility (HP:0000789)2.18873657
64Chorioretinal atrophy (HP:0000533)2.17972344
65Aplastic anemia (HP:0001915)2.15721863
66Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.15215135
67Abnormality of macular pigmentation (HP:0008002)2.13316146
68Abnormality of the renal medulla (HP:0100957)2.12618269
69Carpal synostosis (HP:0009702)2.11925743
70Abnormality of the ileum (HP:0001549)2.10600493
71Abnormal mitochondria in muscle tissue (HP:0008316)2.10333003
72Abnormality of purine metabolism (HP:0004352)2.08453410
73Renal Fanconi syndrome (HP:0001994)2.08302482
74Duplicated collecting system (HP:0000081)2.07235431
75Abnormality of the phalanges of the 5th finger (HP:0004213)2.07007896
76Abnormal spermatogenesis (HP:0008669)2.06293249
77Symphalangism affecting the phalanges of the hand (HP:0009773)2.03581147
78Abnormality of the middle phalanges of the toes (HP:0010183)2.03230454
79Progressive cerebellar ataxia (HP:0002073)2.01021248
80Abnormal drinking behavior (HP:0030082)2.00789695
81Polydipsia (HP:0001959)2.00789695
82Abnormality of dental color (HP:0011073)1.99560754
83Meckel diverticulum (HP:0002245)1.98755281
84Increased corneal curvature (HP:0100692)1.97159577
85Keratoconus (HP:0000563)1.97159577
86Intestinal fistula (HP:0100819)1.96813192
87Abnormality of subcutaneous fat tissue (HP:0001001)1.95400107
88Tubulointerstitial nephritis (HP:0001970)1.95313877
89Acute encephalopathy (HP:0006846)1.92954139
90Tubular atrophy (HP:0000092)1.91797030
91Severe muscular hypotonia (HP:0006829)1.91640923
92Prostate neoplasm (HP:0100787)1.90355986
93Pancreatic fibrosis (HP:0100732)1.89287747
94Reduced subcutaneous adipose tissue (HP:0003758)1.87511845
95Impulsivity (HP:0100710)1.87441671
96Male infertility (HP:0003251)1.87103326
97Menstrual irregularities (HP:0000858)1.86048131
98Molar tooth sign on MRI (HP:0002419)1.84757946
99Abnormality of midbrain morphology (HP:0002418)1.84757946
100Progressive macrocephaly (HP:0004481)1.83453025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.23622063
2TAOK33.37587030
3GRK13.35075353
4INSRR3.17715443
5PLK23.14391709
6CDK92.79401676
7TESK12.46702788
8NUAK12.45621187
9MAP3K92.41687829
10MAP4K22.33562663
11TLK12.24148305
12DDR22.04197191
13ZAK1.97293256
14TAF11.92102455
15ADRBK21.89922686
16STK391.85834101
17TXK1.80817844
18CAMKK21.46157055
19TRIM281.44796954
20PIK3CG1.43475391
21CDC71.36508599
22WNK41.35578247
23MAP3K131.34933511
24MAP2K11.30998853
25CAMK1G1.30965466
26MAPK151.28202643
27ARAF1.26739512
28BRAF1.23318323
29PNCK1.19025060
30WNK11.16437318
31STK381.16260866
32STK38L1.14023963
33OXSR11.13500251
34VRK21.10079881
35MAP3K41.09873284
36NME11.09152073
37TIE11.09075810
38VRK11.08083146
39FRK1.05241783
40IKBKB1.02286248
41AURKA1.00100608
42TEC0.98771283
43CAMK10.94738878
44TYRO30.94277257
45MAP4K10.93158644
46BRD40.83339873
47FES0.82620762
48CDK70.76889500
49PRKD30.76287047
50GRK50.75205670
51NEK60.71746501
52AKT30.71421415
53CAMK1D0.70853124
54MAPK110.69921027
55KIT0.66694266
56MAPKAPK50.66478500
57CAMK40.66265031
58DYRK20.64900504
59STK160.64862251
60TNIK0.61713925
61CSNK1G20.61616236
62PRKAA20.61019041
63PASK0.60747079
64PRKCG0.59713876
65ATR0.57599262
66CSNK1G30.56302415
67MAP2K70.55700944
68CSK0.54908707
69PDK10.53824071
70MAP3K110.52818281
71RPS6KA60.52437111
72TSSK60.51134314
73CSNK1D0.49893054
74ITK0.49031009
75CSNK1A1L0.48995793
76PRKG10.47919993
77MUSK0.47575382
78PTK2B0.46105955
79RPS6KA50.45506293
80PRKCQ0.44701220
81BMPR1B0.44163669
82STK30.43303876
83CSNK1G10.41969362
84RPS6KA10.41955880
85PLK10.41935366
86GSK3B0.41918448
87PIM10.41296866
88SYK0.40378836
89PDPK10.40244433
90PRKACA0.39515266
91CHEK10.38315138
92CHUK0.37285738
93NTRK20.36886310
94PRKCZ0.36606744
95MAPK130.36189220
96NEK90.35450612
97PRKCE0.35218657
98CDK20.33766146
99MST40.33512657
100CAMK2A0.32660041

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.36362081
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.82465150
3Fatty acid biosynthesis_Homo sapiens_hsa000613.72100089
4Allograft rejection_Homo sapiens_hsa053302.83849442
5Autoimmune thyroid disease_Homo sapiens_hsa053202.72827257
6Asthma_Homo sapiens_hsa053102.43480694
7Olfactory transduction_Homo sapiens_hsa047402.27885393
8Type I diabetes mellitus_Homo sapiens_hsa049402.10342043
9Phototransduction_Homo sapiens_hsa047442.07168521
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.05683728
11Basal transcription factors_Homo sapiens_hsa030222.04128944
12Fanconi anemia pathway_Homo sapiens_hsa034602.02694306
13Graft-versus-host disease_Homo sapiens_hsa053321.74447937
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69433472
15Ribosome_Homo sapiens_hsa030101.65487890
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62716486
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.62711659
18Linoleic acid metabolism_Homo sapiens_hsa005911.62604892
19RNA transport_Homo sapiens_hsa030131.60990952
20RNA degradation_Homo sapiens_hsa030181.55789548
21Mismatch repair_Homo sapiens_hsa034301.48825114
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39890413
23Butanoate metabolism_Homo sapiens_hsa006501.38817608
24Dorso-ventral axis formation_Homo sapiens_hsa043201.32912782
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30051703
26Homologous recombination_Homo sapiens_hsa034401.30000067
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29223804
28Taste transduction_Homo sapiens_hsa047421.27489311
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26817707
30Sulfur metabolism_Homo sapiens_hsa009201.21537019
31Primary immunodeficiency_Homo sapiens_hsa053401.20092189
32Systemic lupus erythematosus_Homo sapiens_hsa053221.18737581
33Nicotine addiction_Homo sapiens_hsa050331.18575474
34Oxidative phosphorylation_Homo sapiens_hsa001901.18205475
35RNA polymerase_Homo sapiens_hsa030201.14036685
36Huntingtons disease_Homo sapiens_hsa050161.12086211
37Selenocompound metabolism_Homo sapiens_hsa004501.08635470
38Cardiac muscle contraction_Homo sapiens_hsa042601.08424200
39Retinol metabolism_Homo sapiens_hsa008301.06401176
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05462375
41Fat digestion and absorption_Homo sapiens_hsa049751.00938096
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.97154959
43Morphine addiction_Homo sapiens_hsa050320.95054344
44Alzheimers disease_Homo sapiens_hsa050100.94149821
45Hematopoietic cell lineage_Homo sapiens_hsa046400.90476361
46Ovarian steroidogenesis_Homo sapiens_hsa049130.88604502
47T cell receptor signaling pathway_Homo sapiens_hsa046600.88349609
48Salivary secretion_Homo sapiens_hsa049700.87990516
49Chemical carcinogenesis_Homo sapiens_hsa052040.87449691
50Proteasome_Homo sapiens_hsa030500.86519562
51Nucleotide excision repair_Homo sapiens_hsa034200.85854181
52Tryptophan metabolism_Homo sapiens_hsa003800.84662792
53Fatty acid metabolism_Homo sapiens_hsa012120.83416007
54Antigen processing and presentation_Homo sapiens_hsa046120.83116824
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82960720
56Fatty acid degradation_Homo sapiens_hsa000710.80867601
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.75003130
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71920552
59Parkinsons disease_Homo sapiens_hsa050120.71683433
60Ether lipid metabolism_Homo sapiens_hsa005650.70448435
61One carbon pool by folate_Homo sapiens_hsa006700.66179996
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63211294
63Calcium signaling pathway_Homo sapiens_hsa040200.60501379
64Caffeine metabolism_Homo sapiens_hsa002320.59733241
65Circadian entrainment_Homo sapiens_hsa047130.59703520
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.58080736
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57098332
68Purine metabolism_Homo sapiens_hsa002300.56769334
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54420359
70Nitrogen metabolism_Homo sapiens_hsa009100.53601810
71Glycerolipid metabolism_Homo sapiens_hsa005610.53176184
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52355470
73PPAR signaling pathway_Homo sapiens_hsa033200.51716845
74Peroxisome_Homo sapiens_hsa041460.51389595
75Glutamatergic synapse_Homo sapiens_hsa047240.50630452
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49697075
77Type II diabetes mellitus_Homo sapiens_hsa049300.47370065
78Thyroid cancer_Homo sapiens_hsa052160.46848764
79Alcoholism_Homo sapiens_hsa050340.46533914
80Oocyte meiosis_Homo sapiens_hsa041140.46481596
81Renin secretion_Homo sapiens_hsa049240.45783522
82Fatty acid elongation_Homo sapiens_hsa000620.44956364
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44831661
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42669838
85Regulation of autophagy_Homo sapiens_hsa041400.42063656
86Arginine and proline metabolism_Homo sapiens_hsa003300.42003188
87Serotonergic synapse_Homo sapiens_hsa047260.41117742
88Protein export_Homo sapiens_hsa030600.39608883
89Hedgehog signaling pathway_Homo sapiens_hsa043400.38918807
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37516893
91Insulin secretion_Homo sapiens_hsa049110.36806566
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34662356
93Viral myocarditis_Homo sapiens_hsa054160.33499642
94Circadian rhythm_Homo sapiens_hsa047100.33096854
95Pyrimidine metabolism_Homo sapiens_hsa002400.32988007
96Protein digestion and absorption_Homo sapiens_hsa049740.32955613
97GABAergic synapse_Homo sapiens_hsa047270.31274885
98cAMP signaling pathway_Homo sapiens_hsa040240.30967928
99Arachidonic acid metabolism_Homo sapiens_hsa005900.30582340
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29751395

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