RPS6P22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.60258405
2DNA deamination (GO:0045006)5.31949162
3regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.07189614
4regulation of immunoglobulin secretion (GO:0051023)4.86842569
5regulation of chronic inflammatory response (GO:0002676)4.63071013
6rRNA modification (GO:0000154)4.51125200
7regulation of isotype switching to IgG isotypes (GO:0048302)4.48708201
8cellular response to exogenous dsRNA (GO:0071360)4.42880979
9proteasome assembly (GO:0043248)4.16597535
10water-soluble vitamin biosynthetic process (GO:0042364)4.15487014
11ATP synthesis coupled proton transport (GO:0015986)4.06388610
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.06388610
13positive regulation of DNA recombination (GO:0045911)4.03540569
14ribosomal large subunit biogenesis (GO:0042273)4.03532438
15positive regulation of defense response to virus by host (GO:0002230)4.03018693
16positive regulation of isotype switching (GO:0045830)3.91911549
17ribosomal small subunit assembly (GO:0000028)3.87477287
18sleep (GO:0030431)3.80595495
19chaperone-mediated protein transport (GO:0072321)3.73997120
20pseudouridine synthesis (GO:0001522)3.72948229
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71233721
22rRNA methylation (GO:0031167)3.64834819
23exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.57109352
24maturation of 5.8S rRNA (GO:0000460)3.56172067
25GTP biosynthetic process (GO:0006183)3.48305954
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45156547
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41241780
28somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.39952579
29isotype switching (GO:0045190)3.39952579
30somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.39952579
31behavioral response to nicotine (GO:0035095)3.38117611
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.38082993
33termination of RNA polymerase III transcription (GO:0006386)3.38082993
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.26947671
35rRNA metabolic process (GO:0016072)3.25258578
36rRNA processing (GO:0006364)3.21498250
37regulation of regulatory T cell differentiation (GO:0045589)3.18678386
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18447253
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18447253
40cellular response to dsRNA (GO:0071359)3.18144908
41termination of RNA polymerase I transcription (GO:0006363)3.17131984
42transcription elongation from RNA polymerase I promoter (GO:0006362)3.15953346
43negative regulation of telomere maintenance (GO:0032205)3.13583334
44positive regulation of prostaglandin secretion (GO:0032308)3.12247483
45cytidine metabolic process (GO:0046087)3.10628749
46cytidine catabolic process (GO:0006216)3.10628749
47cytidine deamination (GO:0009972)3.10628749
48piRNA metabolic process (GO:0034587)3.06833452
49positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.06132269
50positive regulation of immunoglobulin mediated immune response (GO:0002891)3.04689905
51positive regulation of B cell mediated immunity (GO:0002714)3.04689905
52UTP biosynthetic process (GO:0006228)3.04268571
53tRNA processing (GO:0008033)3.02662796
54translation (GO:0006412)3.02177879
55rRNA catabolic process (GO:0016075)3.01837017
56cellular response to interferon-beta (GO:0035458)2.99384071
57regulation of defense response to virus by host (GO:0050691)2.94288554
58mannosylation (GO:0097502)2.92772793
59somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87711891
60somatic hypermutation of immunoglobulin genes (GO:0016446)2.87711891
61negative regulation of B cell apoptotic process (GO:0002903)2.87623739
62UTP metabolic process (GO:0046051)2.87336202
63ribonucleoprotein complex biogenesis (GO:0022613)2.86030167
64nucleotide transmembrane transport (GO:1901679)2.85818776
65positive regulation of activated T cell proliferation (GO:0042104)2.79469896
66ribosome assembly (GO:0042255)2.78161188
67guanosine-containing compound biosynthetic process (GO:1901070)2.77908179
68ribosome biogenesis (GO:0042254)2.77882804
69tRNA metabolic process (GO:0006399)2.77785249
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76070755
71tRNA modification (GO:0006400)2.75176433
72regulation of cellular amino acid metabolic process (GO:0006521)2.74771586
73translational elongation (GO:0006414)2.72531287
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71227081
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71227081
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71227081
77viral transcription (GO:0019083)2.70987107
78positive regulation of interleukin-17 production (GO:0032740)2.69439376
79CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.69321776
80ncRNA metabolic process (GO:0034660)2.69114602
81ncRNA processing (GO:0034470)2.68999377
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.68859044
83somatic diversification of immunoglobulins (GO:0016445)2.68579543
84transcription from RNA polymerase I promoter (GO:0006360)2.68480679
85transcription initiation from RNA polymerase I promoter (GO:0006361)2.66357132
86CTP metabolic process (GO:0046036)2.65582436
87CTP biosynthetic process (GO:0006241)2.65582436
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65554349
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65554349
90translational termination (GO:0006415)2.64937391
91pyrimidine ribonucleoside catabolic process (GO:0046133)2.64471014
92cotranslational protein targeting to membrane (GO:0006613)2.64019514
93protein targeting to ER (GO:0045047)2.63457315
94GMP metabolic process (GO:0046037)2.63138756
95cellular component biogenesis (GO:0044085)2.62834648
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60540660
97modulation of growth of symbiont involved in interaction with host (GO:0044144)2.59190407
98regulation of growth of symbiont in host (GO:0044126)2.59190407
99negative regulation of growth of symbiont in host (GO:0044130)2.59190407
100negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.59190407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.70898949
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59932398
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.43886348
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18158331
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.14897789
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08147644
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.05043677
8VDR_22108803_ChIP-Seq_LS180_Human2.83587694
9VDR_23849224_ChIP-Seq_CD4+_Human2.82474270
10ZNF274_21170338_ChIP-Seq_K562_Hela2.77797727
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.69622463
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.46496701
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44000484
14FOXP3_21729870_ChIP-Seq_TREG_Human2.35658228
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.31082595
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.31017606
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.24632870
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22889903
19ELK1_19687146_ChIP-ChIP_HELA_Human2.16482310
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11233176
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04973043
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04023577
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94150854
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93350599
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91329303
26MYC_18940864_ChIP-ChIP_HL60_Human1.88962750
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81747631
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81600277
29EWS_26573619_Chip-Seq_HEK293_Human1.73677578
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.66944327
31TP53_22573176_ChIP-Seq_HFKS_Human1.66592781
32IGF1R_20145208_ChIP-Seq_DFB_Human1.64356794
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60681208
34GATA3_26560356_Chip-Seq_TH2_Human1.57526984
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56354036
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51716503
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51113991
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.50562565
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49629246
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43898563
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.43138263
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43138263
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39857934
44TTF2_22483619_ChIP-Seq_HELA_Human1.35702117
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33634457
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33053170
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31242569
48IRF1_19129219_ChIP-ChIP_H3396_Human1.29625324
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29273174
50AR_20517297_ChIP-Seq_VCAP_Human1.28898902
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27129043
52DCP1A_22483619_ChIP-Seq_HELA_Human1.26462500
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21153364
54ER_23166858_ChIP-Seq_MCF-7_Human1.21077859
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20451878
56GABP_19822575_ChIP-Seq_HepG2_Human1.19922425
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17111144
58NCOR_22424771_ChIP-Seq_293T_Human1.16781619
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16516360
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15616452
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.12561105
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.12530050
63HOXB7_26014856_ChIP-Seq_BT474_Human1.12449720
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11129817
65TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11110988
66SOX2_19829295_ChIP-Seq_ESCs_Human1.11066380
67NANOG_19829295_ChIP-Seq_ESCs_Human1.11066380
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10030383
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08905993
70FOXH1_21741376_ChIP-Seq_EPCs_Human1.08452159
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.06935510
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06618867
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05133866
74GATA3_26560356_Chip-Seq_TH1_Human1.04809548
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01341587
76TAF2_19829295_ChIP-Seq_ESCs_Human1.01136607
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00973390
78MYB_26560356_Chip-Seq_TH2_Human1.00168219
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99389800
80ERA_21632823_ChIP-Seq_H3396_Human0.98895207
81CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98377692
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98248302
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97392681
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96294191
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95484369
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.95336647
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.94622538
88RUNX_20019798_ChIP-Seq_JUKART_Human0.94423541
89FUS_26573619_Chip-Seq_HEK293_Human0.93468036
90MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92660707
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91893433
92P300_19829295_ChIP-Seq_ESCs_Human0.91299071
93NANOG_20526341_ChIP-Seq_ESCs_Human0.90827720
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90614667
95CBP_20019798_ChIP-Seq_JUKART_Human0.90614667
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90529654
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87907236
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87607201
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87388761
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86857170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.79179734
2MP0000685_abnormal_immune_system3.64914074
3MP0005671_abnormal_response_to3.36339048
4MP0008877_abnormal_DNA_methylation3.35400683
5MP0002254_reproductive_system_inflammat2.82564374
6MP0002102_abnormal_ear_morphology2.68142157
7MP0001348_abnormal_lacrimal_gland2.64573912
8MP0002876_abnormal_thyroid_physiology2.51936366
9MP0001873_stomach_inflammation2.29950142
10MP0008872_abnormal_physiological_respon2.17660439
11MP0008058_abnormal_DNA_repair2.16828089
12MP0002148_abnormal_hypersensitivity_rea2.13340228
13MP0002736_abnormal_nociception_after1.99280467
14MP0003195_calcinosis1.96765290
15MP0005646_abnormal_pituitary_gland1.95029468
16MP0001968_abnormal_touch/_nociception1.92650877
17MP0009785_altered_susceptibility_to1.85902236
18MP0000604_amyloidosis1.85512144
19MP0003763_abnormal_thymus_physiology1.81712875
20MP0003786_premature_aging1.80235059
21MP0002138_abnormal_hepatobiliary_system1.73027548
22MP0008875_abnormal_xenobiotic_pharmacok1.72401931
23MP0002166_altered_tumor_susceptibility1.71802853
24MP0005645_abnormal_hypothalamus_physiol1.69170625
25MP0004885_abnormal_endolymph1.64552656
26MP0003646_muscle_fatigue1.64476889
27MP0002006_tumorigenesis1.63252273
28MP0001800_abnormal_humoral_immune1.61665109
29MP0006292_abnormal_olfactory_placode1.59994794
30MP0006072_abnormal_retinal_apoptosis1.57616014
31MP0005387_immune_system_phenotype1.54993601
32MP0001790_abnormal_immune_system1.54993601
33MP0001501_abnormal_sleep_pattern1.53688595
34MP0005000_abnormal_immune_tolerance1.51518920
35MP0000427_abnormal_hair_cycle1.49399005
36MP0005551_abnormal_eye_electrophysiolog1.48609676
37MP0009764_decreased_sensitivity_to1.47482101
38MP0004145_abnormal_muscle_electrophysio1.45282329
39MP0004147_increased_porphyrin_level1.44770972
40MP0005310_abnormal_salivary_gland1.43115421
41MP0009379_abnormal_foot_pigmentation1.37404377
42MP0003693_abnormal_embryo_hatching1.34521142
43MP0001986_abnormal_taste_sensitivity1.30408171
44MP0008995_early_reproductive_senescence1.29222462
45MP0004142_abnormal_muscle_tone1.27837652
46MP0005389_reproductive_system_phenotype1.27211990
47MP0000465_gastrointestinal_hemorrhage1.26804304
48MP0010094_abnormal_chromosome_stability1.26596130
49MP0002723_abnormal_immune_serum1.25817269
50MP0001919_abnormal_reproductive_system1.25579468
51MP0003806_abnormal_nucleotide_metabolis1.21467549
52MP0000372_irregular_coat_pigmentation1.20867145
53MP0002420_abnormal_adaptive_immunity1.20855751
54MP0001819_abnormal_immune_cell1.20708364
55MP0005025_abnormal_response_to1.19018326
56MP0003866_abnormal_defecation1.16704062
57MP0002452_abnormal_antigen_presenting1.16582310
58MP0003436_decreased_susceptibility_to1.13781407
59MP0008789_abnormal_olfactory_epithelium1.13453764
60MP0002160_abnormal_reproductive_system1.11736111
61MP0005084_abnormal_gallbladder_morpholo1.05360439
62MP0001845_abnormal_inflammatory_respons1.05050067
63MP0010155_abnormal_intestine_physiology1.04800275
64MP0003718_maternal_effect1.02987477
65MP0009333_abnormal_splenocyte_physiolog1.02905539
66MP0005167_abnormal_blood-brain_barrier1.02417755
67MP0002405_respiratory_system_inflammati1.02165036
68MP0006082_CNS_inflammation1.01891698
69MP0006035_abnormal_mitochondrial_morpho1.00509551
70MP0002272_abnormal_nervous_system0.98888481
71MP0008775_abnormal_heart_ventricle0.96406548
72MP0003300_gastrointestinal_ulcer0.95174582
73MP0002398_abnormal_bone_marrow0.91687599
74MP0001853_heart_inflammation0.91333924
75MP0001984_abnormal_olfaction0.89655702
76MP0010386_abnormal_urinary_bladder0.88398748
77MP0005410_abnormal_fertilization0.88045976
78MP0000716_abnormal_immune_system0.86512821
79MP0001929_abnormal_gametogenesis0.86266930
80MP0001502_abnormal_circadian_rhythm0.85514330
81MP0005636_abnormal_mineral_homeostasis0.84629891
82MP0002163_abnormal_gland_morphology0.84332929
83MP0002210_abnormal_sex_determination0.83539278
84MP0000689_abnormal_spleen_morphology0.81059585
85MP0009745_abnormal_behavioral_response0.78778918
86MP0003329_amyloid_beta_deposits0.78436722
87MP0006036_abnormal_mitochondrial_physio0.77420675
88MP0001905_abnormal_dopamine_level0.77043209
89MP0001765_abnormal_ion_homeostasis0.76222651
90MP0008469_abnormal_protein_level0.74554392
91MP0002277_abnormal_respiratory_mucosa0.74541498
92MP0001119_abnormal_female_reproductive0.73896396
93MP0001529_abnormal_vocalization0.73820390
94MP0002722_abnormal_immune_system0.73754662
95MP0002429_abnormal_blood_cell0.73690887
96MP0004019_abnormal_vitamin_homeostasis0.73244990
97MP0005253_abnormal_eye_physiology0.71786017
98MP0004133_heterotaxia0.71067406
99MP0003567_abnormal_fetal_cardiomyocyte0.70877340
100MP0002419_abnormal_innate_immunity0.67837586

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.22557802
23-Methylglutaconic aciduria (HP:0003535)4.05335416
3IgG deficiency (HP:0004315)3.78462315
4Increased IgM level (HP:0003496)3.74566908
5Elevated erythrocyte sedimentation rate (HP:0003565)3.67973461
6Lipid accumulation in hepatocytes (HP:0006561)3.54325054
7Acute necrotizing encephalopathy (HP:0006965)3.40671237
8Abnormality of alanine metabolism (HP:0010916)3.37359338
9Hyperalaninemia (HP:0003348)3.37359338
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.37359338
11Methylmalonic acidemia (HP:0002912)3.20646349
12Increased hepatocellular lipid droplets (HP:0006565)3.19337355
13Increased CSF lactate (HP:0002490)3.16035093
14Testicular atrophy (HP:0000029)3.13543698
15Congenital stationary night blindness (HP:0007642)3.09851545
16Acute encephalopathy (HP:0006846)3.08168577
17Prostate neoplasm (HP:0100787)3.05435508
18Congenital, generalized hypertrichosis (HP:0004540)3.04338330
19Mitochondrial inheritance (HP:0001427)3.03988515
20Optic disc pallor (HP:0000543)2.92770917
21Progressive macrocephaly (HP:0004481)2.90906289
22Increased serum lactate (HP:0002151)2.90329309
23Abnormality of the prostate (HP:0008775)2.88980070
24Methylmalonic aciduria (HP:0012120)2.82923604
25Abnormal mitochondria in muscle tissue (HP:0008316)2.78267174
26Asplenia (HP:0001746)2.68877507
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68427373
28Pancreatic cysts (HP:0001737)2.67587646
29Abnormality of the renal cortex (HP:0011035)2.64945398
30Aplasia/Hypoplasia of the spleen (HP:0010451)2.61416630
31Type II lissencephaly (HP:0007260)2.55581051
32IgA deficiency (HP:0002720)2.45065895
33Abnormality of T cell physiology (HP:0011840)2.43446954
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41597786
35Polydipsia (HP:0001959)2.39744401
36Abnormal drinking behavior (HP:0030082)2.39744401
37Abnormal rod and cone electroretinograms (HP:0008323)2.37159826
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35389403
39Autoimmune thrombocytopenia (HP:0001973)2.34817415
40Hepatocellular necrosis (HP:0001404)2.28743802
41Parakeratosis (HP:0001036)2.26214735
42Renal cortical cysts (HP:0000803)2.23174846
43Dyschromatopsia (HP:0007641)2.22256490
44Renal Fanconi syndrome (HP:0001994)2.21226655
45Lactic acidosis (HP:0003128)2.18310814
46Autoimmune hemolytic anemia (HP:0001890)2.16678612
47Hepatic necrosis (HP:0002605)2.15869433
48Attenuation of retinal blood vessels (HP:0007843)2.14213997
49Nephronophthisis (HP:0000090)2.12676356
50Abnormality of the ileum (HP:0001549)2.11581133
51Meckel diverticulum (HP:0002245)2.10202908
52Central scotoma (HP:0000603)2.09738254
53Pendular nystagmus (HP:0012043)2.09259362
54Exertional dyspnea (HP:0002875)2.08508789
55Abnormality of T cells (HP:0002843)2.07843298
56Visual hallucinations (HP:0002367)2.06721310
57Abnormality of cells of the erythroid lineage (HP:0012130)2.06216769
58Decreased central vision (HP:0007663)2.06016930
59Aplasia/hypoplasia of the uterus (HP:0008684)2.05443721
60Recurrent cutaneous fungal infections (HP:0011370)2.03843230
61Chronic mucocutaneous candidiasis (HP:0002728)2.03843230
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.03462473
63Cerebral edema (HP:0002181)2.01243019
64Abnormal number of erythroid precursors (HP:0012131)1.99998034
65Pancytopenia (HP:0001876)1.99410035
66Increased neuronal autofluorescent lipopigment (HP:0002074)1.98200901
67Respiratory difficulties (HP:0002880)1.97320292
68Polyuria (HP:0000103)1.95068025
69Aplasia/Hypoplasia involving the musculature (HP:0001460)1.94207261
70Abolished electroretinogram (ERG) (HP:0000550)1.93599677
71Optic neuritis (HP:0100653)1.91563435
72Retrobulbar optic neuritis (HP:0100654)1.91563435
73Lethargy (HP:0001254)1.91069827
74Abnormality of the vitamin B12 metabolism (HP:0004341)1.90950215
75Abnormality of the renal medulla (HP:0100957)1.90853365
76Pancreatic fibrosis (HP:0100732)1.89862487
77Progressive inability to walk (HP:0002505)1.89557978
78Myositis (HP:0100614)1.89547252
79Tubular atrophy (HP:0000092)1.88248343
80Absent thumb (HP:0009777)1.87397523
81Keratoconjunctivitis (HP:0001096)1.86110227
82Abnormality of male internal genitalia (HP:0000022)1.85925617
83Glycosuria (HP:0003076)1.84937609
84Abnormality of urine glucose concentration (HP:0011016)1.84937609
85Partial agenesis of the corpus callosum (HP:0001338)1.84921641
86Colon cancer (HP:0003003)1.84125382
87Microvesicular hepatic steatosis (HP:0001414)1.83700411
88Increased muscle lipid content (HP:0009058)1.83413867
89Abnormal biliary tract physiology (HP:0012439)1.82741201
90Bile duct proliferation (HP:0001408)1.82741201
91Increased serum pyruvate (HP:0003542)1.82602929
92Clubbing of toes (HP:0100760)1.82067820
93Increased intramyocellular lipid droplets (HP:0012240)1.81356152
94Abnormality of midbrain morphology (HP:0002418)1.80910012
95Molar tooth sign on MRI (HP:0002419)1.80910012
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.79388748
97Absent/shortened dynein arms (HP:0200106)1.79388748
98Amniotic constriction ring (HP:0009775)1.78069576
99Abnormality of placental membranes (HP:0011409)1.78069576
100Respiratory failure (HP:0002878)1.76209135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.72802031
2VRK23.17454552
3TRIM283.11875746
4NUAK13.11250587
5TLK13.06356048
6ADRBK23.00076012
7ZAK2.97553357
8TAOK32.80277625
9MST42.59535381
10BMPR1B2.33357873
11EIF2AK32.28941155
12TXK2.02973135
13STK162.01059984
14GRK11.97684104
15EIF2AK11.91958525
16VRK11.80649653
17MAPKAPK31.64639536
18TAF11.64195185
19OXSR11.60259583
20IKBKB1.53790794
21FES1.53766811
22MAP4K11.50071617
23NME11.50001105
24PBK1.43726416
25SRPK11.38378064
26NEK11.25939611
27MAP2K61.25186321
28EIF2AK21.21599873
29MKNK21.20685431
30PLK31.18956204
31DYRK21.17458787
32STK391.14243529
33CDK81.13626369
34RPS6KB21.12337048
35WNK41.09216031
36BUB11.08820397
37TEC1.06879963
38TSSK61.06444984
39GRK61.01724667
40TIE11.01708402
41KIT1.00304225
42ITK0.97613038
43IRAK10.96816859
44TGFBR10.96327180
45MAP3K140.95242815
46PASK0.93403585
47DAPK10.93176009
48DAPK20.92011690
49PDK20.89977015
50IRAK40.89862940
51RPS6KA40.87383347
52BCKDK0.84663621
53IKBKE0.84597993
54MAPKAPK50.82880598
55WNK30.81257687
56AKT30.79676061
57PHKG20.74360308
58PHKG10.74360308
59ADRBK10.74034202
60RPS6KA50.71373747
61CAMKK20.68448902
62MKNK10.68013221
63MAP2K20.64918663
64PLK20.64815850
65ATR0.61731139
66CSNK1G30.61422246
67PRKCQ0.59405976
68PRKCI0.57936554
69PRKCG0.55531541
70INSRR0.54995993
71GRK50.53897920
72MAP4K20.52910788
73PINK10.52356005
74MAP3K40.51175430
75MUSK0.49926956
76SIK30.49881820
77LYN0.49219395
78CSNK1A1L0.48642738
79PLK10.47521150
80BTK0.46780243
81CSNK1G20.45743385
82CSNK2A20.45522031
83CSNK1G10.43220909
84CSNK1A10.41438346
85PRKCD0.40904376
86EPHA30.40414369
87NME20.40006143
88PRKCE0.38085414
89LCK0.36574576
90CSNK2A10.36375414
91TBK10.34254400
92PRKCA0.34229210
93CDK70.34159598
94PLK40.33623073
95RPS6KB10.33019395
96CAMKK10.32436025
97SYK0.32250982
98AURKB0.31887724
99CASK0.31210026
100CAMK10.31135505

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.95339055
2Proteasome_Homo sapiens_hsa030503.46592907
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.39813112
4Ribosome_Homo sapiens_hsa030103.19269005
5Allograft rejection_Homo sapiens_hsa053303.08326904
6Autoimmune thyroid disease_Homo sapiens_hsa053202.85217015
7Protein export_Homo sapiens_hsa030602.66098116
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61592854
9RNA polymerase_Homo sapiens_hsa030202.46703359
10Oxidative phosphorylation_Homo sapiens_hsa001902.46461659
11Primary immunodeficiency_Homo sapiens_hsa053402.30686133
12Type I diabetes mellitus_Homo sapiens_hsa049402.08805569
13Basal transcription factors_Homo sapiens_hsa030222.04453552
14Parkinsons disease_Homo sapiens_hsa050121.99906845
15Homologous recombination_Homo sapiens_hsa034401.90403271
16Graft-versus-host disease_Homo sapiens_hsa053321.85642963
17RNA degradation_Homo sapiens_hsa030181.84608787
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83074898
19One carbon pool by folate_Homo sapiens_hsa006701.71273157
20Vitamin B6 metabolism_Homo sapiens_hsa007501.63478154
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59633431
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57527463
23Linoleic acid metabolism_Homo sapiens_hsa005911.56134176
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54645576
25Mismatch repair_Homo sapiens_hsa034301.48318554
26Fanconi anemia pathway_Homo sapiens_hsa034601.48202329
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28100773
28Pyrimidine metabolism_Homo sapiens_hsa002401.27801221
29Nucleotide excision repair_Homo sapiens_hsa034201.27163468
30Phototransduction_Homo sapiens_hsa047441.26507920
31Huntingtons disease_Homo sapiens_hsa050161.22764966
32Hematopoietic cell lineage_Homo sapiens_hsa046401.18956888
33Spliceosome_Homo sapiens_hsa030401.18076721
34Alzheimers disease_Homo sapiens_hsa050101.17695677
35Nitrogen metabolism_Homo sapiens_hsa009101.17292538
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16210746
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15676379
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14335021
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14197343
40Rheumatoid arthritis_Homo sapiens_hsa053231.09515006
41RNA transport_Homo sapiens_hsa030131.09084627
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.06381873
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05295266
44Base excision repair_Homo sapiens_hsa034101.02659176
45Cardiac muscle contraction_Homo sapiens_hsa042601.00285486
46Antigen processing and presentation_Homo sapiens_hsa046120.98405899
47Propanoate metabolism_Homo sapiens_hsa006400.97749659
48Purine metabolism_Homo sapiens_hsa002300.96650889
49Ether lipid metabolism_Homo sapiens_hsa005650.94290591
50Non-homologous end-joining_Homo sapiens_hsa034500.93086226
51DNA replication_Homo sapiens_hsa030300.89396484
52Peroxisome_Homo sapiens_hsa041460.85893326
53Caffeine metabolism_Homo sapiens_hsa002320.85772849
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83418740
55Selenocompound metabolism_Homo sapiens_hsa004500.82332890
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81353974
57Arachidonic acid metabolism_Homo sapiens_hsa005900.79021846
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.78840617
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78299353
60Tryptophan metabolism_Homo sapiens_hsa003800.71573259
61T cell receptor signaling pathway_Homo sapiens_hsa046600.71040911
62Sulfur metabolism_Homo sapiens_hsa009200.62217832
63Fat digestion and absorption_Homo sapiens_hsa049750.61385404
64Systemic lupus erythematosus_Homo sapiens_hsa053220.60172854
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59059110
66Steroid biosynthesis_Homo sapiens_hsa001000.58451782
67Olfactory transduction_Homo sapiens_hsa047400.55398786
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.54731105
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53993252
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51685118
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51390266
72Viral myocarditis_Homo sapiens_hsa054160.51214555
73Butanoate metabolism_Homo sapiens_hsa006500.50906142
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.50766415
75Metabolic pathways_Homo sapiens_hsa011000.49322490
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47217100
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46880491
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46869807
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45835146
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43006703
81Herpes simplex infection_Homo sapiens_hsa051680.42759345
82Collecting duct acid secretion_Homo sapiens_hsa049660.42690396
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41731056
84Glycerolipid metabolism_Homo sapiens_hsa005610.39615384
85Measles_Homo sapiens_hsa051620.39028448
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36776529
87Retinol metabolism_Homo sapiens_hsa008300.36267888
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34293973
89Chemical carcinogenesis_Homo sapiens_hsa052040.34282180
90Renin-angiotensin system_Homo sapiens_hsa046140.32386989
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28870829
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.28706140
93Fatty acid elongation_Homo sapiens_hsa000620.28537042
94Epstein-Barr virus infection_Homo sapiens_hsa051690.28529980
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28172578
96Leishmaniasis_Homo sapiens_hsa051400.26973511
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25040754
98Regulation of autophagy_Homo sapiens_hsa041400.24174579
99Vitamin digestion and absorption_Homo sapiens_hsa049770.23478337
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.23060532

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