ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.52817468
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.44202794
3	ATP synthesis coupled proton transport (GO:0015986)	5.44202794
4	ribosomal small subunit assembly (GO:0000028)	5.36411863
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.87271791
6	protein complex biogenesis (GO:0070271)	4.30865913
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.29716593
8	NADH dehydrogenase complex assembly (GO:0010257)	4.29716593
9	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.29716593
10	viral transcription (GO:0019083)	4.21017386
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.17421525
12	translational termination (GO:0006415)	4.08151228
13	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.99492168
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.97413809
15	chaperone-mediated protein transport (GO:0072321)	3.94991525
16	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.93269796
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.87599924
18	respiratory electron transport chain (GO:0022904)	3.83223127
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.82076273
20	protein neddylation (GO:0045116)	3.81833499
21	electron transport chain (GO:0022900)	3.80550391
22	cotranslational protein targeting to membrane (GO:0006613)	3.77486143
23	maturation of SSU-rRNA (GO:0030490)	3.75460678
24	translational elongation (GO:0006414)	3.72187257
25	protein targeting to ER (GO:0045047)	3.72170945
26	ribosomal large subunit biogenesis (GO:0042273)	3.59782256
27	protein localization to endoplasmic reticulum (GO:0070972)	3.58786279
28	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.53977259
29	protein-cofactor linkage (GO:0018065)	3.53677173
30	respiratory chain complex IV assembly (GO:0008535)	3.46683117
31	ribosomal small subunit biogenesis (GO:0042274)	3.46057980
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.39783230
33	translation (GO:0006412)	3.35822201
34	behavioral response to nicotine (GO:0035095)	3.28032056
35	GTP biosynthetic process (GO:0006183)	3.26434650
36	cytochrome complex assembly (GO:0017004)	3.24385704
37	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.23649015
38	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.20305271
39	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.19964510
40	ATP biosynthetic process (GO:0006754)	3.17921308
41	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.12862004
42	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.12862004
43	translational initiation (GO:0006413)	3.08873431
44	regulation of cilium movement (GO:0003352)	3.08811168
45	cellular component biogenesis (GO:0044085)	3.08437675
46	preassembly of GPI anchor in ER membrane (GO:0016254)	3.08156888
47	viral life cycle (GO:0019058)	3.07260731
48	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.04825805
49	kynurenine metabolic process (GO:0070189)	3.02268873
50	hydrogen ion transmembrane transport (GO:1902600)	2.98840448
51	termination of RNA polymerase III transcription (GO:0006386)	2.98441037
52	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.98441037
53	proteasome assembly (GO:0043248)	2.97081768
54	cellular protein complex disassembly (GO:0043624)	2.94902524
55	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.92206481
56	metallo-sulfur cluster assembly (GO:0031163)	2.85939015
57	iron-sulfur cluster assembly (GO:0016226)	2.85939015
58	indole-containing compound catabolic process (GO:0042436)	2.85666882
59	indolalkylamine catabolic process (GO:0046218)	2.85666882
60	tryptophan catabolic process (GO:0006569)	2.85666882
61	fucose catabolic process (GO:0019317)	2.82385535
62	L-fucose metabolic process (GO:0042354)	2.82385535
63	L-fucose catabolic process (GO:0042355)	2.82385535
64	cullin deneddylation (GO:0010388)	2.81864878
65	proton transport (GO:0015992)	2.79670285
66	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.78074368
67	indolalkylamine metabolic process (GO:0006586)	2.77359874
68	rRNA modification (GO:0000154)	2.75219526
69	hydrogen transport (GO:0006818)	2.75079596
70	UTP biosynthetic process (GO:0006228)	2.74610490
71	pseudouridine synthesis (GO:0001522)	2.72079626
72	ribonucleoprotein complex biogenesis (GO:0022613)	2.71264883
73	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.70758146
74	GPI anchor metabolic process (GO:0006505)	2.70369364
75	rRNA processing (GO:0006364)	2.68539439
76	platelet dense granule organization (GO:0060155)	2.68301627
77	rRNA metabolic process (GO:0016072)	2.67877562
78	UTP metabolic process (GO:0046051)	2.67729286
79	maturation of 5.8S rRNA (GO:0000460)	2.67357338
80	base-excision repair, AP site formation (GO:0006285)	2.67040407
81	aldehyde catabolic process (GO:0046185)	2.66465547
82	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.66145355
83	tRNA processing (GO:0008033)	2.63661901
84	protein deneddylation (GO:0000338)	2.63388445
85	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.62246587
86	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.62246587
87	isotype switching (GO:0045190)	2.62246587
88	positive regulation of prostaglandin secretion (GO:0032308)	2.61433427
89	peptidyl-histidine modification (GO:0018202)	2.59135014
90	tryptophan metabolic process (GO:0006568)	2.58879153
91	rRNA catabolic process (GO:0016075)	2.58592322
92	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.57795878
93	protein targeting to mitochondrion (GO:0006626)	2.56545759
94	mast cell activation (GO:0045576)	2.54752974
95	establishment of protein localization to mitochondrion (GO:0072655)	2.54128242
96	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.53325204
97	cytidine metabolic process (GO:0046087)	2.52950217
98	cytidine catabolic process (GO:0006216)	2.52950217
99	cytidine deamination (GO:0009972)	2.52950217
100	mRNA catabolic process (GO:0006402)	2.52357444

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.16536977
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.16522541
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.37377169
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.26433602
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.13142463
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.00336704
7	VDR_22108803_ChIP-Seq_LS180_Human	2.86656754
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.85984699
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79971181
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.79126838
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.60897056
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.48287585
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.34543504
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.31588902
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.14043963
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.07449345
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.06145279
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.04290350
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.03710213
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98832348
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.98431143
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.93026271
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87001756
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.80870155
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.77586583
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.77345758
27	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.72374063
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69551737
29	EWS_26573619_Chip-Seq_HEK293_Human	1.68274906
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65423821
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64835241
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.62735189
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.52136394
34	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.50553008
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49211208
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.42001935
37	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.41118835
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40528734
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.38830287
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35318440
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34692731
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34692731
43	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.33480248
44	FUS_26573619_Chip-Seq_HEK293_Human	1.33240474
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32289677
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30956537
47	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.29861346
48	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28309407
49	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.27387089
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25666899
51	AR_20517297_ChIP-Seq_VCAP_Human	1.23663535
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22523645
53	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21519485
54	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21359891
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21086111
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21065460
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.21065460
58	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.20484069
59	NCOR_22424771_ChIP-Seq_293T_Human	1.19134455
60	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18769169
61	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.17137029
62	ER_23166858_ChIP-Seq_MCF-7_Human	1.15590732
63	P300_19829295_ChIP-Seq_ESCs_Human	1.13193813
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.10792871
65	GATA3_26560356_Chip-Seq_TH2_Human	1.10731109
66	DCP1A_22483619_ChIP-Seq_HELA_Human	1.10663946
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.09879288
68	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09000576
69	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.07173942
70	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.06545631
71	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05377511
72	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.05348201
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05200882
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04672273
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04645454
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02648105
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02648105
78	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.01173725
79	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00584099
80	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.00124945
81	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.00023318
82	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99691636
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99520290
84	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99254692
85	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.99203619
86	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.98501543
87	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98291233
88	TCF4_22108803_ChIP-Seq_LS180_Human	0.97821530
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97478836
90	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.95808527
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94508550
92	GBX2_23144817_ChIP-Seq_PC3_Human	0.94048801
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94046732
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92409820
95	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92392598
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92355573
97	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.91272427
98	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.91246719
99	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.90912764
100	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.90487911

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.08517347
2	MP0003787_abnormal_imprinting	2.94016994
3	MP0008877_abnormal_DNA_methylation	2.59556658
4	MP0004147_increased_porphyrin_level	2.55063689
5	MP0006072_abnormal_retinal_apoptosis	2.48167099
6	MP0008058_abnormal_DNA_repair	2.46983557
7	MP0005671_abnormal_response_to	2.42998394
8	MP0001835_abnormal_antigen_presentation	2.28097248
9	MP0009379_abnormal_foot_pigmentation	2.27255134
10	MP0002138_abnormal_hepatobiliary_system	2.16706702
11	MP0004142_abnormal_muscle_tone	1.98892932
12	MP0005551_abnormal_eye_electrophysiolog	1.98368461
13	MP0008875_abnormal_xenobiotic_pharmacok	1.97969339
14	MP0005377_hearing/vestibular/ear_phenot	1.94105142
15	MP0003878_abnormal_ear_physiology	1.94105142
16	MP0002102_abnormal_ear_morphology	1.91953455
17	MP0008872_abnormal_physiological_respon	1.91715028
18	MP0003806_abnormal_nucleotide_metabolis	1.90240769
19	MP0001968_abnormal_touch/_nociception	1.83899859
20	MP0002736_abnormal_nociception_after	1.82770808
21	MP0003786_premature_aging	1.78289697
22	MP0005084_abnormal_gallbladder_morpholo	1.76457931
23	MP0001986_abnormal_taste_sensitivity	1.74674724
24	MP0008789_abnormal_olfactory_epithelium	1.73612164
25	MP0005075_abnormal_melanosome_morpholog	1.68461647
26	MP0004885_abnormal_endolymph	1.63916864
27	MP0005646_abnormal_pituitary_gland	1.56005347
28	MP0001188_hyperpigmentation	1.55811396
29	MP0003121_genomic_imprinting	1.54533530
30	MP0005253_abnormal_eye_physiology	1.50483776
31	MP0002837_dystrophic_cardiac_calcinosis	1.49182652
32	MP0000685_abnormal_immune_system	1.48892621
33	MP0003646_muscle_fatigue	1.48007069
34	MP0006036_abnormal_mitochondrial_physio	1.43565064
35	MP0002163_abnormal_gland_morphology	1.43015473
36	MP0001529_abnormal_vocalization	1.42978688
37	MP0002272_abnormal_nervous_system	1.42101112
38	MP0003136_yellow_coat_color	1.36702552
39	MP0002876_abnormal_thyroid_physiology	1.36416317
40	MP0006276_abnormal_autonomic_nervous	1.35482776
41	MP0009046_muscle_twitch	1.33350586
42	MP0005645_abnormal_hypothalamus_physiol	1.32713257
43	MP0002638_abnormal_pupillary_reflex	1.28374884
44	MP0001800_abnormal_humoral_immune	1.27906205
45	MP0003195_calcinosis	1.27322323
46	MP0002148_abnormal_hypersensitivity_rea	1.24424163
47	MP0001485_abnormal_pinna_reflex	1.24324886
48	MP0009764_decreased_sensitivity_to	1.23854642
49	MP0006035_abnormal_mitochondrial_morpho	1.23512957
50	MP0004145_abnormal_muscle_electrophysio	1.20508138
51	MP0005389_reproductive_system_phenotype	1.18631755
52	MP0003880_abnormal_central_pattern	1.16603922
53	MP0000372_irregular_coat_pigmentation	1.14294199
54	MP0001501_abnormal_sleep_pattern	1.13961863
55	MP0009745_abnormal_behavioral_response	1.13077184
56	MP0001984_abnormal_olfaction	1.12739439
57	MP0002095_abnormal_skin_pigmentation	1.12571877
58	MP0003186_abnormal_redox_activity	1.11867827
59	MP0002938_white_spotting	1.10242522
60	MP0009785_altered_susceptibility_to	1.10065084
61	MP0005394_taste/olfaction_phenotype	1.09123525
62	MP0005499_abnormal_olfactory_system	1.09123525
63	MP0005174_abnormal_tail_pigmentation	1.07859818
64	MP0002160_abnormal_reproductive_system	1.06470172
65	MP0001970_abnormal_pain_threshold	1.05770485
66	MP0001905_abnormal_dopamine_level	1.05659865
67	MP0002653_abnormal_ependyma_morphology	1.04582956
68	MP0001919_abnormal_reproductive_system	1.04456842
69	MP0003718_maternal_effect	1.01106573
70	MP0001486_abnormal_startle_reflex	1.00576850
71	MP0000631_abnormal_neuroendocrine_gland	1.00228839
72	MP0008995_early_reproductive_senescence	0.99695925
73	MP0001790_abnormal_immune_system	0.99255679
74	MP0005387_immune_system_phenotype	0.99255679
75	MP0003567_abnormal_fetal_cardiomyocyte	0.96750193
76	MP0002723_abnormal_immune_serum	0.96494692
77	MP0003122_maternal_imprinting	0.96450071
78	MP0002234_abnormal_pharynx_morphology	0.95857755
79	MP0005000_abnormal_immune_tolerance	0.95125231
80	MP0005410_abnormal_fertilization	0.94497414
81	MP0003011_delayed_dark_adaptation	0.93219201
82	MP0001764_abnormal_homeostasis	0.91776259
83	MP0002733_abnormal_thermal_nociception	0.88766551
84	MP0004215_abnormal_myocardial_fiber	0.88569565
85	MP0002452_abnormal_antigen_presenting	0.86632941
86	MP0001819_abnormal_immune_cell	0.84078852
87	MP0005379_endocrine/exocrine_gland_phen	0.83850480
88	MP0003866_abnormal_defecation	0.83784406
89	MP0010094_abnormal_chromosome_stability	0.83543405
90	MP0002420_abnormal_adaptive_immunity	0.83149941
91	MP0005195_abnormal_posterior_eye	0.83083574
92	MP0005636_abnormal_mineral_homeostasis	0.81565477
93	MP0004381_abnormal_hair_follicle	0.80144988
94	MP0002229_neurodegeneration	0.76713669
95	MP0001963_abnormal_hearing_physiology	0.75460410
96	MP0000427_abnormal_hair_cycle	0.74717253
97	MP0001440_abnormal_grooming_behavior	0.74161509
98	MP0000049_abnormal_middle_ear	0.71657767
99	MP0008775_abnormal_heart_ventricle	0.70588358
100	MP0001765_abnormal_ion_homeostasis	0.70343203

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.59400727
2	3-Methylglutaconic aciduria (HP:0003535)	4.35308454
3	Acute encephalopathy (HP:0006846)	4.05523336
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.03309294
5	Mitochondrial inheritance (HP:0001427)	3.95045035
6	Progressive macrocephaly (HP:0004481)	3.84444548
7	Increased CSF lactate (HP:0002490)	3.72092736
8	Hepatocellular necrosis (HP:0001404)	3.47984818
9	Abnormality of midbrain morphology (HP:0002418)	3.29092685
10	Molar tooth sign on MRI (HP:0002419)	3.29092685
11	Reticulocytopenia (HP:0001896)	3.09577335
12	Pancreatic cysts (HP:0001737)	3.08353948
13	Hepatic necrosis (HP:0002605)	3.06899489
14	Abolished electroretinogram (ERG) (HP:0000550)	3.04160629
15	Congenital stationary night blindness (HP:0007642)	3.02109263
16	IgG deficiency (HP:0004315)	2.97609173
17	Congenital, generalized hypertrichosis (HP:0004540)	2.93221510
18	Pancreatic fibrosis (HP:0100732)	2.90618340
19	Cerebral edema (HP:0002181)	2.89696196
20	Abnormality of alanine metabolism (HP:0010916)	2.87721517
21	Hyperalaninemia (HP:0003348)	2.87721517
22	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.87721517
23	Increased serum lactate (HP:0002151)	2.87178021
24	Nephronophthisis (HP:0000090)	2.84492619
25	Abnormality of cells of the erythroid lineage (HP:0012130)	2.84346429
26	Increased hepatocellular lipid droplets (HP:0006565)	2.83726389
27	Optic disc pallor (HP:0000543)	2.77145367
28	Lipid accumulation in hepatocytes (HP:0006561)	2.70329915
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.66795349
30	Abnormal number of erythroid precursors (HP:0012131)	2.64622819
31	Medial flaring of the eyebrow (HP:0010747)	2.60626866
32	Lactic acidosis (HP:0003128)	2.51639686
33	Stomatitis (HP:0010280)	2.48325554
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.44326261
35	True hermaphroditism (HP:0010459)	2.44179907
36	Renal Fanconi syndrome (HP:0001994)	2.42724890
37	Abnormality of the renal medulla (HP:0100957)	2.40537571
38	Elevated erythrocyte sedimentation rate (HP:0003565)	2.39082488
39	Abnormality of the renal cortex (HP:0011035)	2.38092744
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.36544414
41	Renal cortical cysts (HP:0000803)	2.34266586
42	Asplenia (HP:0001746)	2.31278378
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.31203988
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.31203988
45	Severe combined immunodeficiency (HP:0004430)	2.29375948
46	Leukodystrophy (HP:0002415)	2.29126022
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.28233766
48	Macrocytic anemia (HP:0001972)	2.26037638
49	Increased intramyocellular lipid droplets (HP:0012240)	2.24637178
50	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.23391351
51	Methylmalonic aciduria (HP:0012120)	2.15789055
52	Lethargy (HP:0001254)	2.15210380
53	Methylmalonic acidemia (HP:0002912)	2.14695976
54	Respiratory failure (HP:0002878)	2.13397556
55	Bile duct proliferation (HP:0001408)	2.10541002
56	Abnormal biliary tract physiology (HP:0012439)	2.10541002
57	Abnormality of the prostate (HP:0008775)	2.10352339
58	Gait imbalance (HP:0002141)	2.10295856
59	Pendular nystagmus (HP:0012043)	2.09562447
60	Type II lissencephaly (HP:0007260)	2.07526060
61	Colon cancer (HP:0003003)	2.07466860
62	Congenital primary aphakia (HP:0007707)	2.05581123
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.01414407
64	Exercise intolerance (HP:0003546)	1.96352793
65	Hypoproteinemia (HP:0003075)	1.92079346
66	Sclerocornea (HP:0000647)	1.92074791
67	Abnormality of serum amino acid levels (HP:0003112)	1.91462414
68	Retinal dysplasia (HP:0007973)	1.90756218
69	Testicular atrophy (HP:0000029)	1.89525046
70	Nephrogenic diabetes insipidus (HP:0009806)	1.87577862
71	CNS demyelination (HP:0007305)	1.86188197
72	Decreased central vision (HP:0007663)	1.85677747
73	Constricted visual fields (HP:0001133)	1.85292407
74	Exertional dyspnea (HP:0002875)	1.85090977
75	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84813579
76	Increased muscle lipid content (HP:0009058)	1.84421236
77	Cleft eyelid (HP:0000625)	1.84115841
78	Aplastic anemia (HP:0001915)	1.82607127
79	Thyroiditis (HP:0100646)	1.80667959
80	Abnormality of renal resorption (HP:0011038)	1.80366664
81	Progressive microcephaly (HP:0000253)	1.79078386
82	Pallor (HP:0000980)	1.78929780
83	Abnormal drinking behavior (HP:0030082)	1.77986741
84	Polydipsia (HP:0001959)	1.77986741
85	Hypothermia (HP:0002045)	1.77630357
86	Hypoplasia of the uterus (HP:0000013)	1.74393326
87	Hyperglycinemia (HP:0002154)	1.74355986
88	Pancytopenia (HP:0001876)	1.74348536
89	Attenuation of retinal blood vessels (HP:0007843)	1.74176850
90	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.69991578
91	Hyperglycinuria (HP:0003108)	1.69258218
92	Abnormality of the labia minora (HP:0012880)	1.66357565
93	Abnormality of B cell number (HP:0010975)	1.64673801
94	Combined immunodeficiency (HP:0005387)	1.64355963
95	Abnormality of magnesium homeostasis (HP:0004921)	1.64270831
96	Stomach cancer (HP:0012126)	1.64063824
97	Absent thumb (HP:0009777)	1.63560733
98	Prostate neoplasm (HP:0100787)	1.63276198
99	Absent/shortened dynein arms (HP:0200106)	1.62976229
100	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.62976229

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.17186849
2	MAP4K2	3.68752253
3	ZAK	3.07086812
4	TXK	3.03774785
5	NUAK1	2.81257782
6	TAOK3	2.77197839
7	TLK1	2.43247977
8	CDK19	2.22725193
9	WNK3	2.20990142
10	MAP3K12	2.03338662
11	GRK1	2.03191852
12	FRK	2.01537632
13	TIE1	1.96089444
14	ADRBK2	1.91704360
15	PDK2	1.82501493
16	WNK4	1.71721873
17	VRK2	1.71262904
18	BCKDK	1.68763504
19	BMPR1B	1.62170093
20	DYRK2	1.58655351
21	MAP4K1	1.56754357
22	VRK1	1.50418515
23	TEC	1.27259492
24	NEK1	1.19653183
25	OXSR1	1.18684406
26	KIT	1.15444235
27	FES	1.11705755
28	IKBKB	1.08772431
29	INSRR	1.05448821
30	GRK7	1.04565232
31	PINK1	1.01587686
32	PLK4	1.00599426
33	MAPK13	0.99802542
34	CSNK1G3	0.97807451
35	CAMKK2	0.97481369
36	BMPR2	0.88192774
37	PASK	0.87778221
38	CSNK1G2	0.86334833
39	ITK	0.85104886
40	DAPK1	0.85094196
41	STK39	0.84405154
42	PHKG2	0.83016984
43	PHKG1	0.83016984
44	TNIK	0.79969983
45	SRPK1	0.77198648
46	CSNK1A1L	0.76618547
47	CSNK1G1	0.74488469
48	SYK	0.74401390
49	TRIM28	0.74380674
50	MAPKAPK3	0.74102281
51	RPS6KA5	0.72877594
52	ATR	0.72558613
53	ADRBK1	0.69488772
54	CDC7	0.68381068
55	ILK	0.68254449
56	BUB1	0.68006985
57	RPS6KA4	0.67135457
58	PRKCQ	0.66750419
59	PLK3	0.64976664
60	LYN	0.61735575
61	KDR	0.60776406
62	MST4	0.58657794
63	MAP2K6	0.58121671
64	BTK	0.58115015
65	ERBB3	0.57518981
66	PBK	0.56620449
67	NME2	0.55318970
68	MYLK	0.54030937
69	MAP3K11	0.54010079
70	MAP3K4	0.52614876
71	MUSK	0.51333056
72	PRKACA	0.50104787
73	EIF2AK3	0.49531147
74	CSF1R	0.49102791
75	CDK8	0.47930388
76	GRK6	0.47508721
77	IKBKE	0.45745514
78	PLK2	0.45529394
79	CSNK1A1	0.45495030
80	MKNK1	0.44360319
81	CCNB1	0.44343954
82	AURKB	0.44117463
83	CSNK2A2	0.43032705
84	TGFBR1	0.42976696
85	BCR	0.42644693
86	CSNK2A1	0.41678073
87	PLK1	0.40405555
88	PRKCG	0.40183026
89	EPHA4	0.40020267
90	MINK1	0.39904705
91	NLK	0.38877019
92	LCK	0.38805985
93	PRKCE	0.37804012
94	DAPK3	0.36829264
95	CHEK2	0.36725795
96	PIK3CA	0.36719795
97	PRKCA	0.36365676
98	CAMK1	0.34647124
99	PIM1	0.33771303
100	EIF2AK2	0.33411293

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.99995857
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.69040850
3	Asthma_Homo sapiens_hsa05310	3.39433770
4	Proteasome_Homo sapiens_hsa03050	3.08757625
5	Parkinsons disease_Homo sapiens_hsa05012	3.07859234
6	Protein export_Homo sapiens_hsa03060	2.60041085
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.57480965
8	Allograft rejection_Homo sapiens_hsa05330	2.46033620
9	RNA polymerase_Homo sapiens_hsa03020	2.43501702
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.29432452
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.10098920
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10079653
13	Huntingtons disease_Homo sapiens_hsa05016	2.00864967
14	Homologous recombination_Homo sapiens_hsa03440	1.99414297
15	Alzheimers disease_Homo sapiens_hsa05010	1.94983306
16	RNA degradation_Homo sapiens_hsa03018	1.87258976
17	Type I diabetes mellitus_Homo sapiens_hsa04940	1.77593084
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.75423092
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71618679
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56478023
21	Phototransduction_Homo sapiens_hsa04744	1.52219565
22	One carbon pool by folate_Homo sapiens_hsa00670	1.51049105
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.47817739
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.46612039
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.45761270
26	Mismatch repair_Homo sapiens_hsa03430	1.45524989
27	DNA replication_Homo sapiens_hsa03030	1.44680123
28	Caffeine metabolism_Homo sapiens_hsa00232	1.44658382
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44065419
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.42379402
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.40824418
32	Basal transcription factors_Homo sapiens_hsa03022	1.38122940
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.36348314
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.30082350
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27786882
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.26120446
37	Propanoate metabolism_Homo sapiens_hsa00640	1.22767642
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.14570170
39	Antigen processing and presentation_Homo sapiens_hsa04612	1.14074151
40	Spliceosome_Homo sapiens_hsa03040	1.12599292
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10390188
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05184872
43	Rheumatoid arthritis_Homo sapiens_hsa05323	1.04509058
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00484454
45	Purine metabolism_Homo sapiens_hsa00230	0.99864407
46	Base excision repair_Homo sapiens_hsa03410	0.99826047
47	RNA transport_Homo sapiens_hsa03013	0.95905173
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92017945
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.85515490
50	Olfactory transduction_Homo sapiens_hsa04740	0.84751307
51	Peroxisome_Homo sapiens_hsa04146	0.83936066
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82583980
53	Regulation of autophagy_Homo sapiens_hsa04140	0.82552090
54	Butanoate metabolism_Homo sapiens_hsa00650	0.80976217
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.77708224
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77274482
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74158398
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71057672
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.68283891
60	Nicotine addiction_Homo sapiens_hsa05033	0.66584200
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.63991922
62	Sulfur metabolism_Homo sapiens_hsa00920	0.63733201
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63522536
64	Metabolic pathways_Homo sapiens_hsa01100	0.62273680
65	Fatty acid elongation_Homo sapiens_hsa00062	0.61777778
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60976580
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60871807
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59966559
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59222564
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57833266
71	Viral myocarditis_Homo sapiens_hsa05416	0.56610523
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56128312
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55342387
74	Retinol metabolism_Homo sapiens_hsa00830	0.52721245
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52704180
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51759038
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50063911
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49664089
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49497711
80	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.49287090
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48566587
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.47808156
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.46723599
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46604673
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41403889
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40141329
87	Morphine addiction_Homo sapiens_hsa05032	0.39164469
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37740689
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.34538070
90	Taste transduction_Homo sapiens_hsa04742	0.31299534
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31032038
92	Fatty acid degradation_Homo sapiens_hsa00071	0.30955269
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.29936265
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29017434
95	Glutathione metabolism_Homo sapiens_hsa00480	0.26286289
96	Leishmaniasis_Homo sapiens_hsa05140	0.24418708
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.22868630
98	Salivary secretion_Homo sapiens_hsa04970	0.21927367
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.20777458
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.19917584

RPS6P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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