ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	presynaptic membrane organization (GO:0097090)	9.99933603
2	neuronal ion channel clustering (GO:0045161)	9.50020591
3	membrane repolarization during action potential (GO:0086011)	9.47450715
4	tongue development (GO:0043586)	9.09005028
5	membrane repolarization (GO:0086009)	7.58503742
6	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	7.21335799
7	potassium ion import (GO:0010107)	6.81905130
8	positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)	5.73853095
9	negative regulation of neurotransmitter secretion (GO:0046929)	5.38518503
10	axonal fasciculation (GO:0007413)	4.88163145
11	regulation of membrane repolarization (GO:0060306)	4.70518596
12	ventricular cardiac muscle cell action potential (GO:0086005)	4.69512711
13	resolution of meiotic recombination intermediates (GO:0000712)	4.62421027
14	mating behavior (GO:0007617)	4.60033504
15	ovulation cycle (GO:0042698)	4.55122204
16	coenzyme A biosynthetic process (GO:0015937)	4.51815819
17	thalamus development (GO:0021794)	4.33957019
18	glucocorticoid biosynthetic process (GO:0006704)	4.27518471
19	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.24313148
20	regulation of astrocyte differentiation (GO:0048710)	4.19415715
21	regulation of heart rate by cardiac conduction (GO:0086091)	4.13709010
22	adult walking behavior (GO:0007628)	4.11775113
23	negative regulation of catenin import into nucleus (GO:0035414)	4.01649919
24	behavioral response to nicotine (GO:0035095)	3.96935467
25	negative regulation of macroautophagy (GO:0016242)	3.74526362
26	negative regulation of neurotransmitter transport (GO:0051589)	3.58473078
27	biotin metabolic process (GO:0006768)	3.56940358
28	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.56693970
29	ribonucleoprotein complex disassembly (GO:0032988)	3.46467526
30	regulation of potassium ion transmembrane transporter activity (GO:1901016)	3.43320203
31	cardiac conduction (GO:0061337)	3.35313780
32	response to acidic pH (GO:0010447)	3.30526296
33	fatty acid transmembrane transport (GO:1902001)	3.21208098
34	organelle disassembly (GO:1903008)	3.07500908
35	response to histamine (GO:0034776)	3.04651242
36	regulation of isotype switching to IgG isotypes (GO:0048302)	3.04417648
37	cardiac muscle cell action potential involved in contraction (GO:0086002)	3.03464078
38	auditory behavior (GO:0031223)	3.01792205
39	ribosomal small subunit assembly (GO:0000028)	3.01710067
40	midbrain development (GO:0030901)	2.98438745
41	telencephalon cell migration (GO:0022029)	2.97008569
42	cellular response to nicotine (GO:0071316)	2.95674419
43	forebrain cell migration (GO:0021885)	2.93628981
44	cardiac muscle cell action potential (GO:0086001)	2.92553113
45	carnitine shuttle (GO:0006853)	2.91938380
46	multicellular organismal signaling (GO:0035637)	2.87288742
47	regulation of regulatory T cell differentiation (GO:0045589)	2.84926984
48	replication fork processing (GO:0031297)	2.83220307
49	positive regulation of interleukin-17 production (GO:0032740)	2.81189842
50	regulation of potassium ion transmembrane transport (GO:1901379)	2.77517427
51	viral transcription (GO:0019083)	2.74802443
52	response to pheromone (GO:0019236)	2.74378702
53	negative regulation of T cell differentiation in thymus (GO:0033085)	2.73000665
54	peptidyl-proline hydroxylation (GO:0019511)	2.71593115
55	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69879401
56	termination of RNA polymerase III transcription (GO:0006386)	2.69879401
57	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.69817630
58	neuron recognition (GO:0008038)	2.67255155
59	phosphatidylglycerol biosynthetic process (GO:0006655)	2.65917078
60	negative regulation of B cell apoptotic process (GO:0002903)	2.65627617
61	translational termination (GO:0006415)	2.61367918
62	positive regulation of filopodium assembly (GO:0051491)	2.59320431
63	respiratory chain complex IV assembly (GO:0008535)	2.58563550
64	neurofilament cytoskeleton organization (GO:0060052)	2.55332625
65	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.54879552
66	deoxyribose phosphate biosynthetic process (GO:0046385)	2.54877458
67	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.54877458
68	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.53077683
69	positive regulation of growth hormone secretion (GO:0060124)	2.52486013
70	myoblast migration (GO:0051451)	2.52044577
71	nucleoside diphosphate catabolic process (GO:0009134)	2.50197076
72	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.48785172
73	regulation of acrosome reaction (GO:0060046)	2.48699363
74	amyloid precursor protein catabolic process (GO:0042987)	2.48527561
75	coenzyme A metabolic process (GO:0015936)	2.48298675
76	negative regulation of response to nutrient levels (GO:0032108)	2.47570838
77	negative regulation of response to extracellular stimulus (GO:0032105)	2.47570838
78	protein neddylation (GO:0045116)	2.46793563
79	forebrain neuron development (GO:0021884)	2.46590995
80	myoblast differentiation (GO:0045445)	2.46541758
81	neuron migration (GO:0001764)	2.44693649
82	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.43636414
83	ATP synthesis coupled proton transport (GO:0015986)	2.43636414
84	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.42744651
85	uterus development (GO:0060065)	2.41886938
86	translational elongation (GO:0006414)	2.39413585
87	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	2.38976160
88	nucleoside bisphosphate biosynthetic process (GO:0033866)	2.38976160
89	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	2.38976160
90	C21-steroid hormone biosynthetic process (GO:0006700)	2.38630662
91	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.38531503
92	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.38311022
93	protein targeting to ER (GO:0045047)	2.38196705
94	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.32594291
95	cotranslational protein targeting to membrane (GO:0006613)	2.31887829
96	substrate-independent telencephalic tangential migration (GO:0021826)	14.3138265
97	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	14.3138265
98	potassium ion export (GO:0071435)	11.5351618
99	axon ensheathment in central nervous system (GO:0032291)	11.0444548
100	central nervous system myelination (GO:0022010)	11.0444548

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IKZF1_21737484_ChIP-ChIP_HCT116_Human	4.47011320
2	VDR_22108803_ChIP-Seq_LS180_Human	3.40276571
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.23242195
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.18066268
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.16161484
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.95415727
7	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.71222063
8	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.65114726
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.49513056
10	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.42324435
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.26316570
12	REST_21632747_ChIP-Seq_MESCs_Mouse	2.16036453
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.00397717
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.95116670
15	FUS_26573619_Chip-Seq_HEK293_Human	1.92970156
16	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.84017889
17	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.82390062
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.81762472
19	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.81430550
20	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.76974580
21	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.72933509
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70436054
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.69147711
24	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.68674183
25	NCOR_22424771_ChIP-Seq_293T_Human	1.66083164
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.65317905
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60844610
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.59209486
29	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.56715061
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.55397395
31	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.49078756
32	HTT_18923047_ChIP-ChIP_STHdh_Human	1.48943902
33	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.43520179
34	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.42137073
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.41499427
36	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.38404553
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.38390820
38	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.32751205
39	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.32063782
40	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.31550835
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.30834556
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29558959
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26567929
44	ETV1_20927104_ChIP-Seq_GIST48_Human	1.25589363
45	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.24649437
46	P53_21459846_ChIP-Seq_SAOS-2_Human	1.22428198
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22341184
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.20508118
49	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20462781
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19872816
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19872816
52	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.19105415
53	MYC_19829295_ChIP-Seq_ESCs_Human	1.18006584
54	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16112863
55	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15536043
56	EZH2_22144423_ChIP-Seq_EOC_Human	1.15170227
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14424885
58	SOX2_21211035_ChIP-Seq_LN229_Human	1.14138976
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.13796630
60	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.13790948
61	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.13542285
62	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.13467374
63	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.13467374
64	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.12014643
65	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.11782521
66	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.11665158
67	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.11551332
68	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.10563517
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.10166906
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09869035
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.09869035
72	RBPJ_21746931_ChIP-Seq_IB4_Human	1.08968174
73	TTF2_22483619_ChIP-Seq_HELA_Human	1.07945704
74	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.07529861
75	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.06203836
76	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.05528044
77	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.04873332
78	CTCF_27219007_Chip-Seq_Bcells_Human	1.04530162
79	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04512366
80	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.03503448
81	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.02994303
82	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.02247285
83	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01988189
84	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.01830833
85	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.01465086
86	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.00037236
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99804761
88	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.97674793
89	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.96979315
90	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.96874855
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95667179
92	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.95368830
93	NFYA_21822215_ChIP-Seq_K562_Human	0.95171250
94	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.95158037
95	NFYB_21822215_ChIP-Seq_K562_Human	0.94574701
96	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.94459530
97	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94134630
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.93278832
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93035871
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93035871

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	9.78318451
2	MP0008004_abnormal_stomach_pH	9.55213738
3	MP0006292_abnormal_olfactory_placode	4.57248153
4	MP0008877_abnormal_DNA_methylation	4.49709628
5	MP0003787_abnormal_imprinting	3.16423390
6	MP0003123_paternal_imprinting	3.12272957
7	MP0002822_catalepsy	3.02343706
8	MP0002163_abnormal_gland_morphology	2.92095233
9	MP0008995_early_reproductive_senescence	2.80430307
10	MP0001188_hyperpigmentation	2.69896452
11	MP0003806_abnormal_nucleotide_metabolis	2.59722137
12	MP0003315_abnormal_perineum_morphology	2.57392787
13	MP0003646_muscle_fatigue	2.10873284
14	MP0001835_abnormal_antigen_presentation	2.02929947
15	MP0005187_abnormal_penis_morphology	1.91715823
16	MP0009379_abnormal_foot_pigmentation	1.88043369
17	MP0002184_abnormal_innervation	1.70945569
18	MP0003693_abnormal_embryo_hatching	1.63127026
19	MP0009745_abnormal_behavioral_response	1.62378160
20	MP0004145_abnormal_muscle_electrophysio	1.61057602
21	MP0003880_abnormal_central_pattern	1.37281329
22	MP0001486_abnormal_startle_reflex	1.30903389
23	MP0005379_endocrine/exocrine_gland_phen	1.28899675
24	MP0001664_abnormal_digestion	1.27690340
25	MP0002876_abnormal_thyroid_physiology	1.21445449
26	MP0003195_calcinosis	1.15803893
27	MP0003786_premature_aging	1.10155254
28	MP0000026_abnormal_inner_ear	1.09319579
29	MP0005360_urolithiasis	1.05521765
30	MP0000955_abnormal_spinal_cord	1.03410690
31	MP0002837_dystrophic_cardiac_calcinosis	0.97741298
32	MP0005085_abnormal_gallbladder_physiolo	0.95094853
33	MP0002752_abnormal_somatic_nervous	0.94904312
34	MP0001853_heart_inflammation	0.92305557
35	MP0009333_abnormal_splenocyte_physiolog	0.92285552
36	MP0000604_amyloidosis	0.85488045
37	MP0002653_abnormal_ependyma_morphology	0.84866345
38	MP0001963_abnormal_hearing_physiology	0.84218721
39	MP0000778_abnormal_nervous_system	0.82107280
40	MP0001905_abnormal_dopamine_level	0.80772885
41	MP0001663_abnormal_digestive_system	0.79520013
42	MP0005646_abnormal_pituitary_gland	0.77542156
43	MP0000647_abnormal_sebaceous_gland	0.77457672
44	MP0000372_irregular_coat_pigmentation	0.76847791
45	MP0003121_genomic_imprinting	0.76665972
46	MP0002138_abnormal_hepatobiliary_system	0.75271747
47	MP0002229_neurodegeneration	0.74902909
48	MP0009764_decreased_sensitivity_to	0.74689890
49	MP0001984_abnormal_olfaction	0.74689057
50	MP0002064_seizures	0.72477840
51	MP0005535_abnormal_body_temperature	0.72375791
52	MP0005551_abnormal_eye_electrophysiolog	0.70749358
53	MP0003868_abnormal_feces_composition	0.69343044
54	MP0002272_abnormal_nervous_system	0.67482840
55	MP0003635_abnormal_synaptic_transmissio	0.67073631
56	MP0002735_abnormal_chemical_nociception	0.65450033
57	MP0002882_abnormal_neuron_morphology	0.65365846
58	MP0002127_abnormal_cardiovascular_syste	0.65261709
59	MP0002909_abnormal_adrenal_gland	0.64081765
60	MP0002572_abnormal_emotion/affect_behav	0.63565020
61	MP0001970_abnormal_pain_threshold	0.60948548
62	MP0000639_abnormal_adrenal_gland	0.60792133
63	MP0005409_darkened_coat_color	0.60241317
64	MP0000049_abnormal_middle_ear	0.60041797
65	MP0004142_abnormal_muscle_tone	0.58949550
66	MP0009697_abnormal_copulation	0.54693695
67	MP0002210_abnormal_sex_determination	0.53529689
68	MP0003119_abnormal_digestive_system	0.53325775
69	MP0003866_abnormal_defecation	0.52449115
70	MP0003136_yellow_coat_color	0.52445653
71	MP0001440_abnormal_grooming_behavior	0.52061380
72	MP0005671_abnormal_response_to	0.51384851
73	MP0006276_abnormal_autonomic_nervous	0.49678612
74	MP0000230_abnormal_systemic_arterial	0.47504970
75	MP0008872_abnormal_physiological_respon	0.45885182
76	MP0003011_delayed_dark_adaptation	0.45475351
77	MP0005381_digestive/alimentary_phenotyp	0.44235496
78	MP0006036_abnormal_mitochondrial_physio	0.44035177
79	MP0005266_abnormal_metabolism	0.43812412
80	MP0002160_abnormal_reproductive_system	0.42901909
81	MP0000534_abnormal_ureter_morphology	0.42753618
82	MP0000470_abnormal_stomach_morphology	0.42305389
83	MP0005365_abnormal_bile_salt	0.41876563
84	MP0000631_abnormal_neuroendocrine_gland	0.41566317
85	MP0003329_amyloid_beta_deposits	0.41223524
86	MP0003879_abnormal_hair_cell	0.40564412
87	MP0005075_abnormal_melanosome_morpholog	0.40262035
88	MP0001286_abnormal_eye_development	0.39663711
89	MP0001986_abnormal_taste_sensitivity	0.39337942
90	MP0009765_abnormal_xenobiotic_induced	0.39328727
91	MP0003942_abnormal_urinary_system	0.38640352
92	MP0005195_abnormal_posterior_eye	0.37689559
93	MP0003953_abnormal_hormone_level	0.37546303
94	MP0002557_abnormal_social/conspecific_i	0.35433277
95	MP0004036_abnormal_muscle_relaxation	0.35167105
96	MP0002148_abnormal_hypersensitivity_rea	0.35121128
97	MP0004130_abnormal_muscle_cell	0.34892446
98	MP0002734_abnormal_mechanical_nocicepti	0.34487760
99	MP0003633_abnormal_nervous_system	0.34476153
100	MP0002063_abnormal_learning/memory/cond	0.33912049

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ventricular fibrillation (HP:0001663)	8.36043673
2	Increased IgM level (HP:0003496)	6.70009861
3	Autoimmune thrombocytopenia (HP:0001973)	6.44091038
4	Abnormality of B cell number (HP:0010975)	6.23696427
5	Stomach cancer (HP:0012126)	6.00269593
6	Metaphyseal dysplasia (HP:0100255)	5.71585419
7	Prolonged QT interval (HP:0001657)	5.27365381
8	Autoimmune hemolytic anemia (HP:0001890)	5.25657285
9	Amaurosis fugax (HP:0100576)	5.17462396
10	Abnormal delayed hypersensitivity skin test (HP:0002963)	5.03092170
11	Syncope (HP:0001279)	4.69471212
12	Neonatal hypoglycemia (HP:0001998)	4.13491140
13	Eosinophilia (HP:0001880)	4.06209635
14	Limb dystonia (HP:0002451)	3.92600871
15	Neoplasm of the adrenal cortex (HP:0100641)	3.74166405
16	Hepatoblastoma (HP:0002884)	3.68671489
17	Sex reversal (HP:0012245)	3.63133155
18	Abnormal sex determination (HP:0012244)	3.63133155
19	Abnormal pancreas size (HP:0012094)	3.57313984
20	3-Methylglutaconic aciduria (HP:0003535)	3.54943342
21	Diastasis recti (HP:0001540)	3.53269574
22	Myotonia (HP:0002486)	3.43525626
23	Hypochromic anemia (HP:0001931)	3.38395538
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.37284226
25	Abnormal EKG (HP:0003115)	3.36268310
26	Absent/shortened dynein arms (HP:0200106)	3.35868219
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.35868219
28	Abnormality of T cell number (HP:0011839)	3.22409120
29	Granulocytopenia (HP:0001913)	3.07496703
30	Abnormality of eosinophils (HP:0001879)	3.05156137
31	Myokymia (HP:0002411)	2.97455344
32	Abolished electroretinogram (ERG) (HP:0000550)	2.97372010
33	Adrenal hypoplasia (HP:0000835)	2.71503618
34	Renal Fanconi syndrome (HP:0001994)	2.55564167
35	Increased hepatocellular lipid droplets (HP:0006565)	2.53297170
36	Progressive inability to walk (HP:0002505)	2.52634260
37	Primary atrial arrhythmia (HP:0001692)	2.51731414
38	Stomatitis (HP:0010280)	2.50080040
39	Supraventricular tachycardia (HP:0004755)	2.49547260
40	Atrial fibrillation (HP:0005110)	2.45982158
41	Lipid accumulation in hepatocytes (HP:0006561)	2.42029292
42	Supraventricular arrhythmia (HP:0005115)	2.40594352
43	Acute necrotizing encephalopathy (HP:0006965)	2.39424395
44	Ventricular arrhythmia (HP:0004308)	2.36810202
45	Congenital stationary night blindness (HP:0007642)	2.34376994
46	Muscle hypertrophy of the lower extremities (HP:0008968)	2.31095635
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.23458026
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.23458026
49	Mitochondrial inheritance (HP:0001427)	2.22826802
50	Abnormality of T cell physiology (HP:0011840)	2.21830481
51	Enlarged kidneys (HP:0000105)	2.18659841
52	Abnormality of magnesium homeostasis (HP:0004921)	2.17202394
53	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.15618736
54	Epiphyseal dysplasia (HP:0002656)	2.14481232
55	Aplastic anemia (HP:0001915)	2.11878820
56	Inability to walk (HP:0002540)	2.11672415
57	Exertional dyspnea (HP:0002875)	2.11641399
58	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.11343778
59	Torticollis (HP:0000473)	2.10315449
60	Abnormal rod and cone electroretinograms (HP:0008323)	2.07844136
61	Abnormal ciliary motility (HP:0012262)	2.06294731
62	Leukocytosis (HP:0001974)	2.02174272
63	Type II lissencephaly (HP:0007260)	2.01060613
64	Increased CSF lactate (HP:0002490)	2.00478456
65	Acute encephalopathy (HP:0006846)	2.00471261
66	Pancreatic cysts (HP:0001737)	2.00123223
67	Hyperalaninemia (HP:0003348)	1.97215773
68	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.97215773
69	Abnormality of alanine metabolism (HP:0010916)	1.97215773
70	Gait imbalance (HP:0002141)	1.96840779
71	Hypergammaglobulinemia (HP:0010702)	1.96814881
72	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.90546893
73	Abnormality of DNA repair (HP:0003254)	1.90392201
74	Nephritis (HP:0000123)	1.88973118
75	Abnormal mitochondria in muscle tissue (HP:0008316)	1.86802459
76	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.85978029
77	Increased intramyocellular lipid droplets (HP:0012240)	1.84900752
78	Growth hormone deficiency (HP:0000824)	1.83650374
79	Elevated erythrocyte sedimentation rate (HP:0003565)	1.83229024
80	Progressive macrocephaly (HP:0004481)	1.83205441
81	Vacuolated lymphocytes (HP:0001922)	1.81577598
82	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.77533512
83	Respiratory difficulties (HP:0002880)	1.77499288
84	Abnormal respiratory motile cilium physiology (HP:0012261)	1.76193669
85	Macrocytic anemia (HP:0001972)	1.75936015
86	Microvesicular hepatic steatosis (HP:0001414)	1.75846387
87	Vasculitis (HP:0002633)	1.75803285
88	Male pseudohermaphroditism (HP:0000037)	1.75510861
89	Macular degeneration (HP:0000608)	1.74020140
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.73923427
91	Lissencephaly (HP:0001339)	1.73522762
92	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.69889676
93	Reticulocytopenia (HP:0001896)	1.68334204
94	Congenital primary aphakia (HP:0007707)	1.68219241
95	Pendular nystagmus (HP:0012043)	1.67540050
96	Increased muscle lipid content (HP:0009058)	1.66503239
97	Pachygyria (HP:0001302)	1.65133407
98	Urticaria (HP:0001025)	1.64880118
99	Pancreatic fibrosis (HP:0100732)	1.64218427
100	Hyperparathyroidism (HP:0000843)	1.63862671

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CAMK1D	7.47779114
2	CAMK1G	6.42794068
3	CASK	3.86002889
4	PINK1	3.42433102
5	WNK3	3.14767020
6	ICK	2.83993649
7	PASK	2.07951745
8	DYRK3	2.06504524
9	MAP3K4	2.05697386
10	DYRK2	1.98587153
11	AKT3	1.98221845
12	ITK	1.82953021
13	ZAK	1.77169411
14	MAP2K7	1.58437106
15	TEC	1.48583259
16	MAP3K6	1.47183766
17	JAK3	1.45603409
18	PDK2	1.41933837
19	PTK2	1.40810772
20	TAOK3	1.40192588
21	PNCK	1.37060456
22	MAP2K6	1.35048281
23	BCKDK	1.29659205
24	MARK1	1.20800969
25	CAMKK2	1.18135881
26	ACVR1B	1.17887956
27	WNK4	1.16055372
28	CAMK1	1.06396014
29	BTK	1.03236917
30	CAMKK1	1.02773200
31	DYRK1B	1.01581217
32	MATK	1.00385056
33	EIF2AK3	0.97222040
34	TLK1	0.93555796
35	GRK1	0.89365875
36	RPS6KA4	0.88383442
37	NUAK1	0.86441145
38	ADRBK2	0.85632574
39	MAP4K2	0.80910672
40	PHKG1	0.80061620
41	PHKG2	0.80061620
42	MAP2K4	0.77415990
43	BRAF	0.75292502
44	MAP3K9	0.72819551
45	PIK3CA	0.72602608
46	CSF1R	0.69586195
47	STK24	0.69545165
48	KIT	0.61808393
49	DYRK1A	0.61760736
50	PRKCE	0.61727313
51	ERBB2	0.59646296
52	SYK	0.59558276
53	MAPK13	0.58177534
54	MAP3K12	0.57822567
55	CDK5	0.57771525
56	PRKAA1	0.53708737
57	NTRK1	0.53650405
58	MINK1	0.52856281
59	LCK	0.52847388
60	RPS6KA5	0.52779017
61	PRKD3	0.52441984
62	SGK2	0.50653245
63	ERBB3	0.50573389
64	TYK2	0.49039173
65	PRKCD	0.48380559
66	EPHA3	0.48279134
67	INSRR	0.48083828
68	TXK	0.46579368
69	FRK	0.45354416
70	PRKACA	0.45287545
71	CSNK1G2	0.44473351
72	IKBKB	0.44312123
73	PRKCG	0.43851183
74	PRKACG	0.43362267
75	TRIM28	0.42026305
76	PRKCA	0.39598725
77	EPHB1	0.39241183
78	BCR	0.38740052
79	PAK1	0.38604006
80	STK11	0.36939039
81	WNK1	0.35248137
82	EGFR	0.33592381
83	RPS6KB1	0.33438326
84	CSNK1G3	0.32748717
85	SGK494	0.32649998
86	SGK223	0.32649998
87	CAMK2A	0.29845163
88	MAPK4	0.27654476
89	CSNK1D	0.24729026
90	PRKCQ	0.23735274
91	OBSCN	0.23262464
92	LYN	0.22724598
93	ABL2	0.22357802
94	BMPR2	0.22313213
95	OXSR1	0.21933502
96	CSK	0.21762965
97	RIPK4	0.20942316
98	DAPK2	0.20713043
99	SRC	0.20634585
100	IGF1R	0.20119654

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.10345408
2	Asthma_Homo sapiens_hsa05310	2.98379041
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.72666478
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.65252274
5	Parkinsons disease_Homo sapiens_hsa05012	2.58737616
6	Allograft rejection_Homo sapiens_hsa05330	2.38697854
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.33487048
8	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.31344408
9	Phototransduction_Homo sapiens_hsa04744	2.26591230
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.25350892
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.23408511
12	Protein export_Homo sapiens_hsa03060	2.21386958
13	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.07214959
14	RNA polymerase_Homo sapiens_hsa03020	2.00733569
15	Morphine addiction_Homo sapiens_hsa05032	2.00731002
16	Proteasome_Homo sapiens_hsa03050	1.95409907
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95306741
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.89893943
19	Propanoate metabolism_Homo sapiens_hsa00640	1.87499804
20	Serotonergic synapse_Homo sapiens_hsa04726	1.85662626
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.70502933
22	Cocaine addiction_Homo sapiens_hsa05030	1.65791148
23	RNA degradation_Homo sapiens_hsa03018	1.63092278
24	Circadian entrainment_Homo sapiens_hsa04713	1.60982839
25	Gastric acid secretion_Homo sapiens_hsa04971	1.52940549
26	GABAergic synapse_Homo sapiens_hsa04727	1.52244573
27	Huntingtons disease_Homo sapiens_hsa05016	1.50452479
28	Glutamatergic synapse_Homo sapiens_hsa04724	1.48094777
29	Dopaminergic synapse_Homo sapiens_hsa04728	1.44073470
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43708854
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41471212
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.35749836
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.33000905
34	Alzheimers disease_Homo sapiens_hsa05010	1.29269051
35	Long-term depression_Homo sapiens_hsa04730	1.26750537
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.26425895
37	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.24220267
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.22899997
39	Nicotine addiction_Homo sapiens_hsa05033	1.20495270
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20127329
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.17731076
42	Sulfur metabolism_Homo sapiens_hsa00920	1.09291760
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.02735488
44	Primary immunodeficiency_Homo sapiens_hsa05340	0.93429243
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92078115
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91863198
47	Olfactory transduction_Homo sapiens_hsa04740	0.90419363
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90026623
49	Rheumatoid arthritis_Homo sapiens_hsa05323	0.87402263
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.87127367
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.86307454
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.84004545
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.82569020
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.81901384
55	Regulation of autophagy_Homo sapiens_hsa04140	0.81644566
56	Cholinergic synapse_Homo sapiens_hsa04725	0.80861032
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79655595
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.78365215
59	Purine metabolism_Homo sapiens_hsa00230	0.72797829
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.69697823
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.61652663
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.60602441
63	Nucleotide excision repair_Homo sapiens_hsa03420	0.59948397
64	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59866422
65	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59456344
66	Insulin secretion_Homo sapiens_hsa04911	0.57812838
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.57560950
68	Nitrogen metabolism_Homo sapiens_hsa00910	0.57151868
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56637928
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55325492
71	Alcoholism_Homo sapiens_hsa05034	0.53068905
72	Metabolic pathways_Homo sapiens_hsa01100	0.51271192
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50377212
74	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.49890515
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49745035
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.48780381
77	Homologous recombination_Homo sapiens_hsa03440	0.46619045
78	Chemokine signaling pathway_Homo sapiens_hsa04062	0.44432134
79	Retinol metabolism_Homo sapiens_hsa00830	0.44381408
80	Salmonella infection_Homo sapiens_hsa05132	0.42955483
81	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.42150017
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40601618
83	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40487028
84	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.40022733
85	Fanconi anemia pathway_Homo sapiens_hsa03460	0.39439256
86	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.39410458
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38850098
88	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.38579955
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37572706
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36665912
91	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.35791817
92	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35389115
93	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.31287246
94	Amphetamine addiction_Homo sapiens_hsa05031	0.30226012
95	One carbon pool by folate_Homo sapiens_hsa00670	0.28472581
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28366568
97	Spliceosome_Homo sapiens_hsa03040	0.27936499
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.27755032
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27159379
100	Chemical carcinogenesis_Homo sapiens_hsa05204	0.26696395

RPS6P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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