RPS7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.80473408
2* ribosomal small subunit biogenesis (GO:0042274)9.33509313
3* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.88710570
4* cotranslational protein targeting to membrane (GO:0006613)8.78789990
5* translational elongation (GO:0006414)8.77629792
6* protein targeting to ER (GO:0045047)8.74424650
7* establishment of protein localization to endoplasmic reticulum (GO:0072599)8.37146139
8* protein localization to endoplasmic reticulum (GO:0070972)8.19327474
9* cellular protein complex disassembly (GO:0043624)8.14203869
10* viral life cycle (GO:0019058)8.11457189
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.02254151
12maturation of SSU-rRNA (GO:0030490)7.90926961
13* translational initiation (GO:0006413)7.53349523
14ribosomal large subunit biogenesis (GO:0042273)7.37771900
15* protein complex disassembly (GO:0043241)7.03823221
16* macromolecular complex disassembly (GO:0032984)6.59428482
17* protein targeting to membrane (GO:0006612)5.82530441
18* nuclear-transcribed mRNA catabolic process (GO:0000956)5.67509290
19* translation (GO:0006412)5.47600120
20* mRNA catabolic process (GO:0006402)5.38595279
21* ribonucleoprotein complex biogenesis (GO:0022613)4.95900587
22* RNA catabolic process (GO:0006401)4.95006240
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.17787374
24* rRNA processing (GO:0006364)4.01018860
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96082811
26ATP synthesis coupled proton transport (GO:0015986)3.96082811
27chaperone-mediated protein transport (GO:0072321)3.94998081
28* establishment of protein localization to membrane (GO:0090150)3.92894582
29* cellular component biogenesis (GO:0044085)3.89954573
30formation of translation preinitiation complex (GO:0001731)3.87277613
31* rRNA metabolic process (GO:0016072)3.86167061
32mitotic chromosome condensation (GO:0007076)3.78773023
33* protein targeting (GO:0006605)3.69694971
34ribosome biogenesis (GO:0042254)3.63199575
35DNA deamination (GO:0045006)3.62728535
36* establishment of protein localization to organelle (GO:0072594)3.60430211
37regulation of mitochondrial translation (GO:0070129)3.50377609
38heterochromatin organization (GO:0070828)3.49424845
39termination of RNA polymerase III transcription (GO:0006386)3.45051547
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.45051547
41ncRNA 3-end processing (GO:0043628)3.34305814
42regulation of translational fidelity (GO:0006450)3.32246643
43proteasome assembly (GO:0043248)3.30584666
44establishment of integrated proviral latency (GO:0075713)3.29520678
45telomere maintenance via semi-conservative replication (GO:0032201)3.25873184
46DNA replication checkpoint (GO:0000076)3.20339861
47DNA strand elongation involved in DNA replication (GO:0006271)3.18947156
48spliceosomal snRNP assembly (GO:0000387)3.18817367
49GTP biosynthetic process (GO:0006183)3.14884900
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05963566
51* protein localization to membrane (GO:0072657)3.05887103
52spliceosomal complex assembly (GO:0000245)3.03613476
53DNA strand elongation (GO:0022616)3.01709371
54protein localization to chromosome, centromeric region (GO:0071459)2.99206576
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99158192
56UTP biosynthetic process (GO:0006228)2.97374980
57oxidative phosphorylation (GO:0006119)2.95946751
58nuclear pore complex assembly (GO:0051292)2.93289605
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91054571
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88128266
61pseudouridine synthesis (GO:0001522)2.87574654
62nucleobase-containing small molecule interconversion (GO:0015949)2.86694584
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.83859538
64establishment of viral latency (GO:0019043)2.83066777
65DNA damage response, detection of DNA damage (GO:0042769)2.82572207
66telomere maintenance via recombination (GO:0000722)2.81196681
67mitotic sister chromatid segregation (GO:0000070)2.80357218
68mitotic metaphase plate congression (GO:0007080)2.80306947
69DNA replication-independent nucleosome organization (GO:0034724)2.78541894
70DNA replication-independent nucleosome assembly (GO:0006336)2.78541894
71kinetochore organization (GO:0051383)2.78353759
72DNA unwinding involved in DNA replication (GO:0006268)2.78242518
73histone mRNA metabolic process (GO:0008334)2.77756337
74establishment of protein localization to mitochondrial membrane (GO:0090151)2.77424437
75ribonucleoprotein complex assembly (GO:0022618)2.77199842
76* ncRNA processing (GO:0034470)2.76976647
77negative regulation of RNA splicing (GO:0033119)2.76172377
78protein localization to kinetochore (GO:0034501)2.75936843
79transcription elongation from RNA polymerase I promoter (GO:0006362)2.73693517
80protein targeting to mitochondrion (GO:0006626)2.73394353
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73024700
82negative regulation of ligase activity (GO:0051352)2.73024700
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70033107
84* cellular component disassembly (GO:0022411)2.69727638
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69712533
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68761294
87nucleotide-excision repair, DNA gap filling (GO:0006297)2.67600747
88purine nucleobase biosynthetic process (GO:0009113)2.66563994
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66009962
90* protein localization to organelle (GO:0033365)2.65525840
91termination of RNA polymerase I transcription (GO:0006363)2.65512034
92nuclear pore organization (GO:0006999)2.65440113
93CTP metabolic process (GO:0046036)2.65261073
94CTP biosynthetic process (GO:0006241)2.65261073
95respiratory electron transport chain (GO:0022904)2.65258545
96CENP-A containing nucleosome assembly (GO:0034080)2.65159819
97transcription-coupled nucleotide-excision repair (GO:0006283)2.64894227
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64383435
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64383435
100chromatin assembly or disassembly (GO:0006333)2.63488932
101DNA topological change (GO:0006265)2.63294711
102mitotic recombination (GO:0006312)2.63176803
103ribonucleoprotein complex subunit organization (GO:0071826)2.62114087
104positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61400731
105* gene expression (GO:0010467)2.61365783
106DNA replication initiation (GO:0006270)2.60882931
107electron transport chain (GO:0022900)2.60501328
108pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.59703437
109signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.59339326
110signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59339326
111signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.59339326
112chromatin remodeling at centromere (GO:0031055)2.57837384
113sister chromatid segregation (GO:0000819)2.57534831
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.57275792
115nucleobase biosynthetic process (GO:0046112)2.56653494
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.55935468
117signal transduction involved in DNA integrity checkpoint (GO:0072401)2.55935468
118pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.55728720
119establishment of protein localization to mitochondrion (GO:0072655)2.55499026
120myeloid cell homeostasis (GO:0002262)2.54242990
121aerobic respiration (GO:0009060)2.54112336
122pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.53773376
123* ncRNA metabolic process (GO:0034660)2.53714994
124telomere maintenance via telomere lengthening (GO:0010833)2.53380061
125mitochondrial respiratory chain complex I assembly (GO:0032981)2.52544726
126NADH dehydrogenase complex assembly (GO:0010257)2.52544726
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.52544726
1287-methylguanosine mRNA capping (GO:0006370)2.52523900
129signal transduction involved in cell cycle checkpoint (GO:0072395)2.52418507
1307-methylguanosine RNA capping (GO:0009452)2.51939848
131kinetochore assembly (GO:0051382)2.49930017
132termination of RNA polymerase II transcription (GO:0006369)2.49787494
133mRNA splicing, via spliceosome (GO:0000398)2.49108145
134RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.49108145
135IMP biosynthetic process (GO:0006188)2.47135239
136folic acid-containing compound biosynthetic process (GO:0009396)2.46934638
137RNA splicing, via transesterification reactions (GO:0000375)2.45886131
138pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.44575503
139* viral transcription (GO:0019083)10.9068734
140* translational termination (GO:0006415)10.4691468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.43734521
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.37744538
3* MYC_18555785_ChIP-Seq_MESCs_Mouse5.05439209
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90030030
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.81329376
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.71950687
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.67556276
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50581181
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.40723494
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.05131624
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01107691
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00610711
13* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93389699
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91602104
15* XRN2_22483619_ChIP-Seq_HELA_Human2.88080760
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87839189
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86362014
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83707488
19* VDR_23849224_ChIP-Seq_CD4+_Human2.68071135
20* TTF2_22483619_ChIP-Seq_HELA_Human2.54738386
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54573997
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52718436
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43149180
24DCP1A_22483619_ChIP-Seq_HELA_Human2.39762327
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37650631
26ELK1_19687146_ChIP-ChIP_HELA_Human2.32988752
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.30301948
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29900456
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28560437
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.16717295
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02887465
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02227257
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.98503421
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82396056
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78868329
36ZNF263_19887448_ChIP-Seq_K562_Human1.78376285
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76008917
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74898140
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74618305
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74107842
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73751683
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.70706053
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70010960
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67260165
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65946751
46* GABP_19822575_ChIP-Seq_HepG2_Human1.65503757
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64693470
48* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63786097
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.61398217
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.60054798
51MYC_18940864_ChIP-ChIP_HL60_Human1.54752945
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.51134850
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49934347
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47585626
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.43575963
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42812937
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36549356
58SPI1_23547873_ChIP-Seq_NB4_Human1.30688855
59CIITA_25753668_ChIP-Seq_RAJI_Human1.30172165
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29866371
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26122812
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24367757
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.22183474
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20639674
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.19084678
66VDR_21846776_ChIP-Seq_THP-1_Human1.18419313
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15480813
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15233701
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14650706
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14315081
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14091142
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13273179
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12915886
74KDM5A_27292631_Chip-Seq_BREAST_Human1.12368634
75MYC_22102868_ChIP-Seq_BL_Human1.11611063
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09023539
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08953455
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07393129
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05662084
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05142116
81* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04408454
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04242858
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03890731
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02668757
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01503975
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98914528
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98512887
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97879228
89* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97441356
90IRF1_19129219_ChIP-ChIP_H3396_Human0.96273777
91TP63_19390658_ChIP-ChIP_HaCaT_Human0.95280078
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94903400
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94737083
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94522313
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94522313
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94522313
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94033067
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92355406
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91767960
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90760286
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90489455
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90300500
103CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90014246
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88970546
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88058822
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87218047
107SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86077711
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85244487
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84068440
110MAF_26560356_Chip-Seq_TH2_Human0.82372600
111SCL_19346495_ChIP-Seq_HPC-7_Human0.81240531
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81203257
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79257429
114* AR_21909140_ChIP-Seq_LNCAP_Human0.79163214
115KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77050810
116UTX_26944678_Chip-Seq_JUKART_Human0.76812260
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76376285
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75375115
119* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74308764
120* ELF5_23300383_ChIP-Seq_T47D_Human0.72831660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.74520746
2MP0003693_abnormal_embryo_hatching3.47275389
3MP0004957_abnormal_blastocyst_morpholog3.10378819
4MP0010094_abnormal_chromosome_stability2.58212506
5MP0008057_abnormal_DNA_replication2.49369288
6MP0003077_abnormal_cell_cycle2.35118853
7MP0002396_abnormal_hematopoietic_system2.29523302
8MP0004381_abnormal_hair_follicle2.28623262
9MP0003763_abnormal_thymus_physiology2.24800130
10MP0000566_synostosis2.14984286
11MP0005174_abnormal_tail_pigmentation2.11259198
12MP0003111_abnormal_nucleus_morphology2.02557159
13MP0008058_abnormal_DNA_repair1.99202479
14MP0003136_yellow_coat_color1.90673527
15MP0008932_abnormal_embryonic_tissue1.88916288
16MP0000490_abnormal_crypts_of1.85378448
17MP0009333_abnormal_splenocyte_physiolog1.81169647
18MP0003786_premature_aging1.80147783
19MP0008007_abnormal_cellular_replicative1.76346095
20MP0001293_anophthalmia1.73042187
21MP0001835_abnormal_antigen_presentation1.71450762
22MP0002095_abnormal_skin_pigmentation1.71168506
23MP0002132_abnormal_respiratory_system1.69012708
24MP0005671_abnormal_response_to1.62137816
25MP0002163_abnormal_gland_morphology1.61254857
26MP0002697_abnormal_eye_size1.61160195
27MP0000685_abnormal_immune_system1.60553878
28MP0001672_abnormal_embryogenesis/_devel1.59797421
29MP0005380_embryogenesis_phenotype1.59797421
30MP0001800_abnormal_humoral_immune1.59103721
31MP0002398_abnormal_bone_marrow1.52453855
32MP0002938_white_spotting1.52034843
33MP0000372_irregular_coat_pigmentation1.49275719
34MP0000537_abnormal_urethra_morphology1.46790911
35MP0003984_embryonic_growth_retardation1.45126978
36MP0002102_abnormal_ear_morphology1.44972807
37MP0004808_abnormal_hematopoietic_stem1.42851843
38MP0005075_abnormal_melanosome_morpholog1.42741913
39MP0000703_abnormal_thymus_morphology1.42291464
40MP0002085_abnormal_embryonic_tissue1.40982168
41MP0002166_altered_tumor_susceptibility1.40090890
42MP0002088_abnormal_embryonic_growth/wei1.38814524
43MP0009053_abnormal_anal_canal1.38760726
44MP0002160_abnormal_reproductive_system1.38525275
45MP0002420_abnormal_adaptive_immunity1.37854571
46MP0000465_gastrointestinal_hemorrhage1.37520112
47MP0009785_altered_susceptibility_to1.36850150
48MP0002722_abnormal_immune_system1.36689811
49MP0003186_abnormal_redox_activity1.34906294
50MP0001819_abnormal_immune_cell1.34303233
51MP0001286_abnormal_eye_development1.32362011
52MP0002452_abnormal_antigen_presenting1.31099576
53MP0002148_abnormal_hypersensitivity_rea1.30476936
54MP0005000_abnormal_immune_tolerance1.30428960
55MP0002723_abnormal_immune_serum1.27374789
56MP0002084_abnormal_developmental_patter1.27078373
57MP0000689_abnormal_spleen_morphology1.26725348
58MP0003724_increased_susceptibility_to1.26507897
59MP0005409_darkened_coat_color1.25749050
60MP0002210_abnormal_sex_determination1.25464243
61MP0003315_abnormal_perineum_morphology1.25159027
62MP0000716_abnormal_immune_system1.24624905
63MP0005025_abnormal_response_to1.23443814
64MP0004185_abnormal_adipocyte_glucose1.22644925
65MP0009672_abnormal_birth_weight1.22288954
66MP0003941_abnormal_skin_development1.21725846
67MP0003937_abnormal_limbs/digits/tail_de1.21295639
68MP0003806_abnormal_nucleotide_metabolis1.21217620
69MP0002429_abnormal_blood_cell1.20293500
70MP0002092_abnormal_eye_morphology1.19559676
71MP0002277_abnormal_respiratory_mucosa1.19355945
72MP0006292_abnormal_olfactory_placode1.15251417
73MP0002006_tumorigenesis1.14871988
74MP0000350_abnormal_cell_proliferation1.14693494
75MP0010307_abnormal_tumor_latency1.14563649
76MP0001986_abnormal_taste_sensitivity1.12143485
77MP0001853_heart_inflammation1.10972673
78MP0003866_abnormal_defecation1.09977585
79MP0002405_respiratory_system_inflammati1.09843242
80MP0003942_abnormal_urinary_system1.09602771
81MP0008995_early_reproductive_senescence1.08190997
82MP0010155_abnormal_intestine_physiology1.05937843
83MP0006035_abnormal_mitochondrial_morpho1.05880735
84MP0005501_abnormal_skin_physiology1.04429389
85MP0002019_abnormal_tumor_incidence1.04246056
86MP0001873_stomach_inflammation1.03657910
87MP0001145_abnormal_male_reproductive1.03292372
88MP0003567_abnormal_fetal_cardiomyocyte1.02826111
89MP0000678_abnormal_parathyroid_gland1.01479076
90MP0003890_abnormal_embryonic-extraembry1.01301741
91MP0001790_abnormal_immune_system1.00665732
92MP0005387_immune_system_phenotype1.00665732
93MP0002796_impaired_skin_barrier0.99301204
94MP0000762_abnormal_tongue_morphology0.98053807
95MP0002111_abnormal_tail_morphology0.97671328
96MP0002086_abnormal_extraembryonic_tissu0.97302604
97MP0002233_abnormal_nose_morphology0.96614978
98MP0000313_abnormal_cell_death0.96274579
99MP0002249_abnormal_larynx_morphology0.95597248
100MP0001545_abnormal_hematopoietic_system0.95460449
101MP0005397_hematopoietic_system_phenotyp0.95460449
102MP0003436_decreased_susceptibility_to0.93333819
103MP0001881_abnormal_mammary_gland0.92448063
104MP0004197_abnormal_fetal_growth/weight/0.91350193
105MP0003123_paternal_imprinting0.90055928
106MP0002009_preneoplasia0.89738356
107MP0001188_hyperpigmentation0.88691477
108MP0003938_abnormal_ear_development0.87799108
109MP0010030_abnormal_orbit_morphology0.87374685
110MP0006036_abnormal_mitochondrial_physio0.86575134
111MP0005076_abnormal_cell_differentiation0.86514254
112MP0001730_embryonic_growth_arrest0.85054477
113MP0000428_abnormal_craniofacial_morphol0.84714711
114MP0000653_abnormal_sex_gland0.84519646
115MP0005394_taste/olfaction_phenotype0.84240980
116MP0005499_abnormal_olfactory_system0.84240980
117MP0001929_abnormal_gametogenesis0.83884946
118MP0001529_abnormal_vocalization0.82870915
119MP0009697_abnormal_copulation0.82242915
120MP0003385_abnormal_body_wall0.81205174
121MP0005379_endocrine/exocrine_gland_phen0.80691465
122MP0003718_maternal_effect0.80349426
123MP0000358_abnormal_cell_content/0.79781447
124MP0000858_altered_metastatic_potential0.79763796
125MP0006054_spinal_hemorrhage0.79615096
126MP0009250_abnormal_appendicular_skeleto0.78882391
127MP0001346_abnormal_lacrimal_gland0.78050014
128MP0003705_abnormal_hypodermis_morpholog0.77811201
129MP0002638_abnormal_pupillary_reflex0.77008602
130MP0002282_abnormal_trachea_morphology0.76899344
131MP0001348_abnormal_lacrimal_gland0.75962750
132MP0005389_reproductive_system_phenotype0.74644036
133MP0001216_abnormal_epidermal_layer0.74215478
134MP0000613_abnormal_salivary_gland0.73499961
135MP0002877_abnormal_melanocyte_morpholog0.73464606
136MP0003861_abnormal_nervous_system0.71972429
137MP0003755_abnormal_palate_morphology0.71629088
138MP0000383_abnormal_hair_follicle0.70724641
139MP0002098_abnormal_vibrissa_morphology0.70197947
140MP0002751_abnormal_autonomic_nervous0.69935968
141MP0000049_abnormal_middle_ear0.69245689
142MP0000627_abnormal_mammary_gland0.67901251
143MP0002080_prenatal_lethality0.67656944
144MP0001905_abnormal_dopamine_level0.66953266
145MP0001697_abnormal_embryo_size0.65905559
146MP0001727_abnormal_embryo_implantation0.65790236
147MP0001340_abnormal_eyelid_morphology0.63675659
148MP0002933_joint_inflammation0.63135710
149MP0008789_abnormal_olfactory_epithelium0.63091585
150MP0005408_hypopigmentation0.62441112
151MP0003936_abnormal_reproductive_system0.62207526
152MP0002060_abnormal_skin_morphology0.62126463
153MP0002116_abnormal_craniofacial_bone0.61119117
154MP0002932_abnormal_joint_morphology0.60297896
155MP0003935_abnormal_craniofacial_develop0.59259339
156MP0000477_abnormal_intestine_morphology0.58609774

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.35611654
2Reticulocytopenia (HP:0001896)8.45068381
3Abnormal number of erythroid precursors (HP:0012131)8.26475573
4* Macrocytic anemia (HP:0001972)6.16823419
5* Pallor (HP:0000980)5.73382021
6Abnormal hemoglobin (HP:0011902)4.16523454
7Increased hepatocellular lipid droplets (HP:0006565)3.99301331
8Aplasia/Hypoplasia of the sacrum (HP:0008517)3.82841490
9Mitochondrial inheritance (HP:0001427)3.55060914
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49579936
11Acute necrotizing encephalopathy (HP:0006965)3.46060025
12Thrombocytosis (HP:0001894)3.44615089
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.42337665
14Lipid accumulation in hepatocytes (HP:0006561)3.33473110
15Chromsome breakage (HP:0040012)3.31543524
16Exertional dyspnea (HP:0002875)3.28292112
17Congenital, generalized hypertrichosis (HP:0004540)3.27673607
18Aplastic anemia (HP:0001915)3.23862772
19Colon cancer (HP:0003003)3.19288935
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.09678714
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05252147
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05252147
23Renal Fanconi syndrome (HP:0001994)3.05191334
24Hepatocellular necrosis (HP:0001404)3.05022928
25Abnormal mitochondria in muscle tissue (HP:0008316)3.01068626
26Increased CSF lactate (HP:0002490)2.89957677
27Progressive macrocephaly (HP:0004481)2.87013457
2811 pairs of ribs (HP:0000878)2.84235274
293-Methylglutaconic aciduria (HP:0003535)2.80374089
30Respiratory difficulties (HP:0002880)2.80342829
31Absent thumb (HP:0009777)2.74355846
32Increased intramyocellular lipid droplets (HP:0012240)2.69448238
33Progressive muscle weakness (HP:0003323)2.65095523
34Stenosis of the external auditory canal (HP:0000402)2.60691307
35* Depressed nasal ridge (HP:0000457)2.59619686
36Trismus (HP:0000211)2.56355900
37Abnormality of reticulocytes (HP:0004312)2.53447999
38IgM deficiency (HP:0002850)2.50935997
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.50564638
40Oral leukoplakia (HP:0002745)2.49236351
41Acute encephalopathy (HP:0006846)2.48894467
42Cerebral edema (HP:0002181)2.44838801
43Missing ribs (HP:0000921)2.43766378
44Triphalangeal thumb (HP:0001199)2.42334122
45Broad distal phalanx of finger (HP:0009836)2.36012767
46Abnormality of cochlea (HP:0000375)2.34187163
47Parakeratosis (HP:0001036)2.31364592
48Asplenia (HP:0001746)2.31130410
49Hepatic necrosis (HP:0002605)2.28664142
50Woolly hair (HP:0002224)2.23701820
51Multiple enchondromatosis (HP:0005701)2.20252321
52Increased serum lactate (HP:0002151)2.19211939
53Chronic otitis media (HP:0000389)2.18334983
54* Migraine (HP:0002076)2.17558013
55Abnormality of the parietal bone (HP:0002696)2.17222343
56Meckel diverticulum (HP:0002245)2.16063568
57Abnormality of the axillary hair (HP:0100134)2.13676845
58Abnormality of secondary sexual hair (HP:0009888)2.13676845
59Exercise intolerance (HP:0003546)2.13652655
60Hypoplasia of the radius (HP:0002984)2.10897545
61Increased muscle lipid content (HP:0009058)2.08983796
62Glossoptosis (HP:0000162)2.08968269
63Rough bone trabeculation (HP:0100670)2.08781343
64Birth length less than 3rd percentile (HP:0003561)2.07939298
65* Thick lower lip vermilion (HP:0000179)2.07919399
66Breast hypoplasia (HP:0003187)2.07593802
67Elevated erythrocyte sedimentation rate (HP:0003565)2.06431134
68Partial duplication of thumb phalanx (HP:0009944)2.05426934
69Dysphonia (HP:0001618)2.04687528
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.04681851
71Partial duplication of the phalanx of hand (HP:0009999)2.01780426
72Microvesicular hepatic steatosis (HP:0001414)1.99535077
73Abnormality of the ileum (HP:0001549)1.98748423
74Cleft eyelid (HP:0000625)1.97500028
75Concave nail (HP:0001598)1.92003563
76Nasolacrimal duct obstruction (HP:0000579)1.88896075
77Amniotic constriction ring (HP:0009775)1.88000280
78Abnormality of placental membranes (HP:0011409)1.88000280
79Sparse eyelashes (HP:0000653)1.87432591
80Progressive external ophthalmoplegia (HP:0000590)1.86197936
81Pancytopenia (HP:0001876)1.84550268
82Panhypogammaglobulinemia (HP:0003139)1.83943239
83IgG deficiency (HP:0004315)1.83669880
84Short middle phalanx of the 5th finger (HP:0004220)1.83291689
85Gout (HP:0001997)1.83125473
86Increased serum pyruvate (HP:0003542)1.82997324
87Abnormality of the preputium (HP:0100587)1.80174051
88Facial cleft (HP:0002006)1.79890613
89Recurrent bronchitis (HP:0002837)1.79883708
90Septo-optic dysplasia (HP:0100842)1.79117845
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.79085690
92Respiratory failure (HP:0002878)1.78720798
93Congenital ichthyosiform erythroderma (HP:0007431)1.78380245
94Sparse lateral eyebrow (HP:0005338)1.77488957
95Aplasia/Hypoplasia of the thymus (HP:0010515)1.77439053
96Premature graying of hair (HP:0002216)1.77438752
97Myelodysplasia (HP:0002863)1.76298562
98Poikiloderma (HP:0001029)1.75719965
99Abnormality of the lacrimal duct (HP:0011481)1.72555206
100Optic disc pallor (HP:0000543)1.71589605
101Morphological abnormality of the inner ear (HP:0011390)1.71236757
102Abnormality of glycolysis (HP:0004366)1.70816479
103Type I transferrin isoform profile (HP:0003642)1.70360747
104Fragile nails (HP:0001808)1.69575818
105Horseshoe kidney (HP:0000085)1.68590088
106Squamous cell carcinoma (HP:0002860)1.68075801
107Increased nuchal translucency (HP:0010880)1.67726005
108Irregular epiphyses (HP:0010582)1.67199525
109Microretrognathia (HP:0000308)1.66888485
110Lymphoma (HP:0002665)1.66719881
111Abnormality of renal resorption (HP:0011038)1.65820234
112Petechiae (HP:0000967)1.64986494
113Megaloblastic anemia (HP:0001889)1.64216847
114Abnormality of DNA repair (HP:0003254)1.63903298
115Diastasis recti (HP:0001540)1.63526245
116Basal cell carcinoma (HP:0002671)1.62469356
117Atresia of the external auditory canal (HP:0000413)1.62352085
118Agammaglobulinemia (HP:0004432)1.61725818
119Premature ovarian failure (HP:0008209)1.60928412
120Overlapping toe (HP:0001845)1.60631233
121Abnormality of the nasolacrimal system (HP:0000614)1.59834334
122Lactic acidosis (HP:0003128)1.59738167
123Ectopic kidney (HP:0000086)1.59611533
124Abnormal number of incisors (HP:0011064)1.58788008
125Abnormality of the heme biosynthetic pathway (HP:0010472)1.58766652
126Testicular atrophy (HP:0000029)1.58625735
127Secondary amenorrhea (HP:0000869)1.57605081
128Abnormality of chromosome stability (HP:0003220)1.57287730
129Duplication of thumb phalanx (HP:0009942)1.57253732
130Absent radius (HP:0003974)1.56803973
131Abnormality of the phalanges of the hallux (HP:0010057)1.56368264
132Esophageal atresia (HP:0002032)1.55471107
133Tracheoesophageal fistula (HP:0002575)1.55458001
134Muscle fiber atrophy (HP:0100295)1.55113512
135Abnormal lung lobation (HP:0002101)1.54797302
136Small epiphyses (HP:0010585)1.54757839
137Leukodystrophy (HP:0002415)1.53501662
138Abnormality of T cells (HP:0002843)1.53117192
139Nephroblastoma (Wilms tumor) (HP:0002667)1.51654939
140Short thumb (HP:0009778)1.51624334
141Cerebral hypomyelination (HP:0006808)1.51026024
142Dry hair (HP:0011359)1.50391314
143Septate vagina (HP:0001153)1.49487134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.40353189
2TLK13.72967766
3VRK23.29982924
4BUB13.29685213
5STK162.86325510
6WEE12.84129922
7EIF2AK12.81958697
8MST42.46246915
9VRK12.45119017
10SRPK12.37556243
11RPS6KB22.34508133
12PIM22.24506838
13SMG12.23996098
14DYRK32.22781538
15MAP4K12.06398873
16TGFBR12.03166600
17NEK12.00563833
18NME12.00287358
19LRRK21.74117150
20MKNK11.71025623
21EIF2AK31.59457793
22SCYL21.57657214
23CDK191.50895284
24CDC71.48754242
25PASK1.48048667
26ZAK1.46341647
27TAF11.44006611
28TRIB31.40685708
29EEF2K1.37229066
30PBK1.36428193
31BRAF1.34668335
32TSSK61.33805876
33ACVR1B1.32973657
34TEC1.30930493
35TESK21.29966809
36BLK1.26354605
37ICK1.24043908
38AURKB1.19808898
39PRPF4B1.18333799
40CDK71.13336641
41BRSK11.12479646
42PDK21.11688162
43CDK121.11334338
44ARAF1.09550894
45KDR1.08802998
46MAPKAPK51.04802109
47BTK1.02772108
48IRAK41.02055908
49RPS6KA51.01842534
50KIT1.01746847
51TNIK1.01415093
52MKNK20.99716327
53TXK0.99406059
54NLK0.99139700
55RPS6KA40.95659556
56DYRK20.95260893
57NEK20.93362943
58FLT30.93315766
59BMPR1B0.91067109
60CDK80.88729718
61BRSK20.87990537
62GRK60.87877113
63PLK10.86910163
64ILK0.86847459
65FES0.86696488
66ZAP700.86325049
67IKBKB0.85954156
68CSNK2A20.85397137
69STK240.83816111
70PIM10.83382969
71PLK30.79113691
72AURKA0.78803929
73SYK0.77799510
74LATS20.76677594
75PNCK0.76233660
76CLK10.74656840
77LCK0.74045917
78EIF2AK20.73596733
79STK100.73223497
80CDK20.71611008
81MAP3K120.71481686
82CSNK2A10.69552368
83LYN0.67270441
84TYRO30.66510433
85MAPKAPK30.64398279
86GRK70.62965740
87ATR0.62866587
88AKT20.60568404
89CSF1R0.59192579
90DYRK1B0.57751675
91CDK10.57188662
92MAPK40.56502443
93STK40.55617800
94WNK40.55559024
95ADRBK20.55385735
96MAP3K110.54987029
97IKBKE0.53826571
98CSNK1E0.53231703
99MAP3K90.53108740
100CSNK1G30.51141775
101MAP3K80.50308614
102DAPK30.50272580
103MAP3K100.50044499
104STK30.48876925
105ITK0.48502689
106PAK10.48466173
107PLK40.48275294
108TBK10.48110785
109LIMK10.47026053
110ALK0.46545333
111ADRBK10.46189881
112PAK40.45490502
113TYK20.45359073
114RPS6KC10.45302440
115RPS6KL10.45302440
116MAP2K20.43740852
117UHMK10.43634756
118CCNB10.42739723
119CDK60.42388452
120CDK40.41971204
121CDK11A0.41481319
122FGFR40.41480144
123MTOR0.40483057
124RPS6KA10.40383280
125JAK30.39483364
126TTK0.39414159
127ABL20.38467631
128RPS6KB10.38450575
129CHEK20.38313073
130PAK20.38068163
131CDK90.37418472
132CSNK1G10.36930434
133FGFR10.36858011
134IRAK30.36840600
135SIK10.36815543
136CHEK10.36506527
137MELK0.36176055
138CDK30.36003920
139GRK10.35030456
140RPS6KA60.34930958
141YES10.34625889
142MAP3K130.33351217
143ATM0.31803671
144PTK60.31372047
145MAP2K60.31357070
146IRAK20.29518809

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.24175287
2RNA polymerase_Homo sapiens_hsa030203.39934413
3Proteasome_Homo sapiens_hsa030503.33504036
4DNA replication_Homo sapiens_hsa030303.29981858
5Spliceosome_Homo sapiens_hsa030402.90450995
6Mismatch repair_Homo sapiens_hsa034302.84257946
7Oxidative phosphorylation_Homo sapiens_hsa001902.65512669
8Parkinsons disease_Homo sapiens_hsa050122.46837461
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43192945
10Homologous recombination_Homo sapiens_hsa034402.27680879
11Protein export_Homo sapiens_hsa030602.24008827
12Nucleotide excision repair_Homo sapiens_hsa034202.22212607
13Pyrimidine metabolism_Homo sapiens_hsa002402.19454230
14Base excision repair_Homo sapiens_hsa034101.91343182
15RNA transport_Homo sapiens_hsa030131.90959318
16Huntingtons disease_Homo sapiens_hsa050161.89217245
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69903104
18Alzheimers disease_Homo sapiens_hsa050101.68158775
19Primary immunodeficiency_Homo sapiens_hsa053401.58046335
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55286937
21Non-homologous end-joining_Homo sapiens_hsa034501.52076950
22Basal transcription factors_Homo sapiens_hsa030221.48530625
23Fanconi anemia pathway_Homo sapiens_hsa034601.48521523
24RNA degradation_Homo sapiens_hsa030181.40857271
25Systemic lupus erythematosus_Homo sapiens_hsa053221.27488226
26Cell cycle_Homo sapiens_hsa041101.25937763
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20684680
28One carbon pool by folate_Homo sapiens_hsa006701.19886204
29Biosynthesis of amino acids_Homo sapiens_hsa012301.09045622
30Purine metabolism_Homo sapiens_hsa002301.06358789
31Epstein-Barr virus infection_Homo sapiens_hsa051691.04220922
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02875920
33Cysteine and methionine metabolism_Homo sapiens_hsa002700.99002133
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98890551
35p53 signaling pathway_Homo sapiens_hsa041150.97982776
36Antigen processing and presentation_Homo sapiens_hsa046120.95426143
37Sulfur relay system_Homo sapiens_hsa041220.89761862
38Pyruvate metabolism_Homo sapiens_hsa006200.89649325
39Hematopoietic cell lineage_Homo sapiens_hsa046400.88871272
40mRNA surveillance pathway_Homo sapiens_hsa030150.87540650
41Carbon metabolism_Homo sapiens_hsa012000.87432078
42Herpes simplex infection_Homo sapiens_hsa051680.83385011
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.73578733
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.72223923
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71174417
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68673495
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68216769
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63579099
49Allograft rejection_Homo sapiens_hsa053300.61646505
50Measles_Homo sapiens_hsa051620.61481407
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60209587
52Folate biosynthesis_Homo sapiens_hsa007900.59985895
53Cardiac muscle contraction_Homo sapiens_hsa042600.59555974
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59436610
55Alcoholism_Homo sapiens_hsa050340.57845776
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57222770
57Viral carcinogenesis_Homo sapiens_hsa052030.55123304
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.54549955
59Asthma_Homo sapiens_hsa053100.54305736
60Selenocompound metabolism_Homo sapiens_hsa004500.53809266
61Graft-versus-host disease_Homo sapiens_hsa053320.51871420
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50744310
63Bladder cancer_Homo sapiens_hsa052190.50436344
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50205455
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.49978975
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49741408
67Glutathione metabolism_Homo sapiens_hsa004800.45681088
68T cell receptor signaling pathway_Homo sapiens_hsa046600.45418005
69Arachidonic acid metabolism_Homo sapiens_hsa005900.44360956
70Chronic myeloid leukemia_Homo sapiens_hsa052200.44195866
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44096036
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.43684616
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42934347
74HTLV-I infection_Homo sapiens_hsa051660.42232657
75Autoimmune thyroid disease_Homo sapiens_hsa053200.41477353
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41322952
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.41243462
78B cell receptor signaling pathway_Homo sapiens_hsa046620.40906332
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39742427
80Vitamin B6 metabolism_Homo sapiens_hsa007500.39303117
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38993853
82Hedgehog signaling pathway_Homo sapiens_hsa043400.38686342
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37369068
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36850835
85Legionellosis_Homo sapiens_hsa051340.36617244
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35641393
87Wnt signaling pathway_Homo sapiens_hsa043100.34067657
88Vitamin digestion and absorption_Homo sapiens_hsa049770.33980954
89Thyroid cancer_Homo sapiens_hsa052160.33027746
90Shigellosis_Homo sapiens_hsa051310.32655795
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32613242
92Galactose metabolism_Homo sapiens_hsa000520.32488615
93Apoptosis_Homo sapiens_hsa042100.31863273
94Non-small cell lung cancer_Homo sapiens_hsa052230.31319959
95Leishmaniasis_Homo sapiens_hsa051400.29227068
96Malaria_Homo sapiens_hsa051440.28711671
97Hepatitis B_Homo sapiens_hsa051610.28611753
98Small cell lung cancer_Homo sapiens_hsa052220.28285983
99Fructose and mannose metabolism_Homo sapiens_hsa000510.28068694
100Metabolic pathways_Homo sapiens_hsa011000.27946341
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27542029
102Hippo signaling pathway_Homo sapiens_hsa043900.26400693
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26201123
104Acute myeloid leukemia_Homo sapiens_hsa052210.25384389
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25189187
106Sphingolipid metabolism_Homo sapiens_hsa006000.24576866
107Pentose phosphate pathway_Homo sapiens_hsa000300.24469079
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24070840
109Viral myocarditis_Homo sapiens_hsa054160.23286459
110Tyrosine metabolism_Homo sapiens_hsa003500.23267507
111Steroid biosynthesis_Homo sapiens_hsa001000.23078943
112N-Glycan biosynthesis_Homo sapiens_hsa005100.22867701
113Fat digestion and absorption_Homo sapiens_hsa049750.22186082
114Arginine and proline metabolism_Homo sapiens_hsa003300.21371274
115Pancreatic cancer_Homo sapiens_hsa052120.20716484
116Fatty acid elongation_Homo sapiens_hsa000620.20714687
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19768714
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19478077
119Ether lipid metabolism_Homo sapiens_hsa005650.19301412
120Linoleic acid metabolism_Homo sapiens_hsa005910.19281420
121Pathways in cancer_Homo sapiens_hsa052000.18136406
122Pertussis_Homo sapiens_hsa051330.18108704
123Influenza A_Homo sapiens_hsa051640.18081794
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17339027
125TGF-beta signaling pathway_Homo sapiens_hsa043500.16738918
126Arginine biosynthesis_Homo sapiens_hsa002200.16377920
127Basal cell carcinoma_Homo sapiens_hsa052170.16361741
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.16339638
129Platelet activation_Homo sapiens_hsa046110.15274689
130MicroRNAs in cancer_Homo sapiens_hsa052060.15048560
131Oocyte meiosis_Homo sapiens_hsa041140.14378348
132Colorectal cancer_Homo sapiens_hsa052100.14113634
133Prostate cancer_Homo sapiens_hsa052150.13427922
134Other glycan degradation_Homo sapiens_hsa005110.13063567
135Notch signaling pathway_Homo sapiens_hsa043300.13048480
136HIF-1 signaling pathway_Homo sapiens_hsa040660.12833494
137Propanoate metabolism_Homo sapiens_hsa006400.12291781
138Phototransduction_Homo sapiens_hsa047440.11808497
139Toxoplasmosis_Homo sapiens_hsa051450.11541091
140Melanoma_Homo sapiens_hsa052180.10951364
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08563197
142Lysine degradation_Homo sapiens_hsa003100.08560390
143Phenylalanine metabolism_Homo sapiens_hsa003600.07666115
144Prion diseases_Homo sapiens_hsa050200.06677911

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