ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	9.56170214
2	viral transcription (GO:0019083)	9.11966638
3	translational termination (GO:0006415)	8.76131193
4	ribosomal small subunit assembly (GO:0000028)	8.60978108
5	translational elongation (GO:0006414)	7.62649357
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.35957187
7	cotranslational protein targeting to membrane (GO:0006613)	7.20883367
8	maturation of SSU-rRNA (GO:0030490)	7.19967862
9	protein targeting to ER (GO:0045047)	7.17198583
10	chaperone-mediated protein transport (GO:0072321)	6.87607684
11	viral life cycle (GO:0019058)	6.87344143
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.85334098
13	protein localization to endoplasmic reticulum (GO:0070972)	6.74912905
14	cellular protein complex disassembly (GO:0043624)	6.72192262
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.54154167
16	ATP synthesis coupled proton transport (GO:0015986)	6.20645224
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.20645224
18	translational initiation (GO:0006413)	5.88277679
19	protein complex disassembly (GO:0043241)	5.61855369
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.36497885
21	macromolecular complex disassembly (GO:0032984)	5.28285879
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.22863106
23	translation (GO:0006412)	5.11758257
24	ribosomal large subunit biogenesis (GO:0042273)	4.98478324
25	ribonucleoprotein complex biogenesis (GO:0022613)	4.98254165
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.88331204
27	protein targeting to membrane (GO:0006612)	4.86653481
28	protein neddylation (GO:0045116)	4.73383517
29	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.72535501
30	DNA deamination (GO:0045006)	4.63882510
31	cellular component biogenesis (GO:0044085)	4.63730613
32	respiratory electron transport chain (GO:0022904)	4.48364282
33	mRNA catabolic process (GO:0006402)	4.44338599
34	behavioral response to nicotine (GO:0035095)	4.41015618
35	electron transport chain (GO:0022900)	4.40247183
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.38515953
37	NADH dehydrogenase complex assembly (GO:0010257)	4.38515953
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.38515953
39	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.34120817
40	protein complex biogenesis (GO:0070271)	4.23157760
41	RNA catabolic process (GO:0006401)	4.01845998
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.84653977
43	protein targeting to mitochondrion (GO:0006626)	3.77717138
44	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.72106731
45	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.69389068
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.68939044
47	rRNA processing (GO:0006364)	3.65394762
48	establishment of protein localization to mitochondrion (GO:0072655)	3.54499114
49	rRNA metabolic process (GO:0016072)	3.52840526
50	pyrimidine nucleotide catabolic process (GO:0006244)	3.52496605
51	ATP biosynthetic process (GO:0006754)	3.50969708
52	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.49273717
53	ribosome biogenesis (GO:0042254)	3.44532117
54	GTP biosynthetic process (GO:0006183)	3.43903078
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.43291122
56	water-soluble vitamin biosynthetic process (GO:0042364)	3.42584543
57	protein localization to mitochondrion (GO:0070585)	3.31889096
58	protein targeting (GO:0006605)	3.30352633
59	establishment of protein localization to membrane (GO:0090150)	3.29306415
60	intracellular protein transmembrane import (GO:0044743)	3.23524746
61	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.16775543
62	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.12516669
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.08752383
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.08752383
65	establishment of protein localization to organelle (GO:0072594)	3.04816746
66	regulation of cellular respiration (GO:0043457)	3.02732912
67	ncRNA 3-end processing (GO:0043628)	2.96575195
68	UTP biosynthetic process (GO:0006228)	2.95907870
69	proteasome assembly (GO:0043248)	2.92860727
70	hydrogen ion transmembrane transport (GO:1902600)	2.92507732
71	termination of RNA polymerase III transcription (GO:0006386)	2.92281143
72	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.92281143
73	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.86289009
74	pseudouridine synthesis (GO:0001522)	2.83384301
75	base-excision repair, AP site formation (GO:0006285)	2.80145309
76	cytidine metabolic process (GO:0046087)	2.79087980
77	cytidine catabolic process (GO:0006216)	2.79087980
78	cytidine deamination (GO:0009972)	2.79087980
79	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.77958863
80	mitochondrial transport (GO:0006839)	2.76276270
81	CTP biosynthetic process (GO:0006241)	2.75448006
82	CTP metabolic process (GO:0046036)	2.75448006
83	UTP metabolic process (GO:0046051)	2.74528980
84	nucleoside triphosphate biosynthetic process (GO:0009142)	2.72306943
85	proton transport (GO:0015992)	2.71755984
86	deoxyribonucleotide catabolic process (GO:0009264)	2.71250058
87	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.67429906
88	negative regulation of T cell differentiation in thymus (GO:0033085)	2.67001943
89	hydrogen transport (GO:0006818)	2.66819673
90	positive regulation of T cell apoptotic process (GO:0070234)	2.64685958
91	aldehyde catabolic process (GO:0046185)	2.64519579
92	peptidyl-histidine modification (GO:0018202)	2.63184769
93	respiratory chain complex IV assembly (GO:0008535)	2.61058208
94	pattern specification involved in kidney development (GO:0061004)	2.60867362
95	deoxyribose phosphate catabolic process (GO:0046386)	2.60290130
96	cardiovascular system development (GO:0072358)	2.59510855
97	protein-cofactor linkage (GO:0018065)	2.58332592
98	cell proliferation in forebrain (GO:0021846)	2.57261310
99	ncRNA processing (GO:0034470)	2.55839074
100	protein localization to membrane (GO:0072657)	2.55762134

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.51466734
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.93945654
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.44990079
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.38762880
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.35489189
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.33447385
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.22080125
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.02742446
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.02039059
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.94287183
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.86389571
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86354849
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.78696540
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.44017450
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.39913379
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.36630883
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.29981596
18	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.08964387
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.07099580
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.06345464
21	TTF2_22483619_ChIP-Seq_HELA_Human	1.96044189
22	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.93452794
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.93188698
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.93066847
25	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.92581445
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79845819
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.79779369
28	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.77984876
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.73475560
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.73416845
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.71202921
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.69972851
33	VDR_22108803_ChIP-Seq_LS180_Human	1.69603084
34	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.68728344
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.62272606
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.61061514
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.56449185
38	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.55204588
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.54454082
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53370866
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47859584
42	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.46291189
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.42245421
44	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.37725703
45	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36347721
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.35699984
47	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.35274445
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34331737
49	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.32411011
50	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.31711944
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.28676844
52	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.26638570
53	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.26563492
54	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.25266932
55	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.25148493
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.24877713
57	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.21186297
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20737850
59	ZNF274_21170338_ChIP-Seq_K562_Hela	1.18980834
60	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.18159849
61	DCP1A_22483619_ChIP-Seq_HELA_Human	1.17797679
62	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.15109943
63	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.14258975
64	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14057240
65	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13228282
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10603320
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.10358500
68	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10241596
69	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09560233
70	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08590482
71	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.08535941
72	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.08532907
73	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.07226092
74	ERA_21632823_ChIP-Seq_H3396_Human	1.07140668
75	CTCF_20526341_ChIP-Seq_ESCs_Human	1.07077557
76	BCL6_27268052_Chip-Seq_Bcells_Human	1.06983585
77	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.06221677
78	E2F1_20622854_ChIP-Seq_HELA_Human	1.05795585
79	TP53_22573176_ChIP-Seq_HFKS_Human	1.05650308
80	SA1_27219007_Chip-Seq_Bcells_Human	1.05253275
81	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03943944
82	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.03610689
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03121903
84	RNF2_27304074_Chip-Seq_NSC_Mouse	1.02932880
85	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.02004806
86	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.00029651
87	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97505363
88	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.96198705
89	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.91068345
90	P68_20966046_ChIP-Seq_HELA_Human	0.90584228
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90285814
92	NCOR_22424771_ChIP-Seq_293T_Human	0.89946448
93	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.89094194
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86885078
95	AR_20517297_ChIP-Seq_VCAP_Human	0.85289557
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.84805607
97	KDM5A_27292631_Chip-Seq_BREAST_Human	0.84470729
98	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.83733136
99	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.82664147
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.82315118

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.59592588
2	MP0006292_abnormal_olfactory_placode	4.32121575
3	MP0002638_abnormal_pupillary_reflex	2.82145819
4	MP0002102_abnormal_ear_morphology	2.70588937
5	MP0003878_abnormal_ear_physiology	2.65206204
6	MP0005377_hearing/vestibular/ear_phenot	2.65206204
7	MP0002163_abnormal_gland_morphology	2.53692437
8	MP0002653_abnormal_ependyma_morphology	2.32769825
9	MP0001188_hyperpigmentation	2.25273192
10	MP0003646_muscle_fatigue	2.15765443
11	MP0008789_abnormal_olfactory_epithelium	2.03810783
12	MP0004145_abnormal_muscle_electrophysio	1.97925218
13	MP0002837_dystrophic_cardiac_calcinosis	1.97827681
14	MP0003567_abnormal_fetal_cardiomyocyte	1.92072288
15	MP0002277_abnormal_respiratory_mucosa	1.91643323
16	MP0000049_abnormal_middle_ear	1.91332172
17	MP0003123_paternal_imprinting	1.90955682
18	MP0002160_abnormal_reproductive_system	1.89728951
19	MP0001529_abnormal_vocalization	1.86784809
20	MP0006072_abnormal_retinal_apoptosis	1.83641238
21	MP0004142_abnormal_muscle_tone	1.60864478
22	MP0005499_abnormal_olfactory_system	1.58654648
23	MP0005394_taste/olfaction_phenotype	1.58654648
24	MP0000566_synostosis	1.56655887
25	MP0005389_reproductive_system_phenotype	1.55546264
26	MP0008875_abnormal_xenobiotic_pharmacok	1.54607430
27	MP0005646_abnormal_pituitary_gland	1.51066844
28	MP0005379_endocrine/exocrine_gland_phen	1.49750502
29	MP0010030_abnormal_orbit_morphology	1.48199838
30	MP0000631_abnormal_neuroendocrine_gland	1.45040262
31	MP0009333_abnormal_splenocyte_physiolog	1.43412439
32	MP0001485_abnormal_pinna_reflex	1.40297067
33	MP0003186_abnormal_redox_activity	1.37887042
34	MP0006036_abnormal_mitochondrial_physio	1.34485944
35	MP0002138_abnormal_hepatobiliary_system	1.33989496
36	MP0001293_anophthalmia	1.31774967
37	MP0005671_abnormal_response_to	1.31410083
38	MP0004885_abnormal_endolymph	1.31127189
39	MP0000678_abnormal_parathyroid_gland	1.29394164
40	MP0001919_abnormal_reproductive_system	1.27191691
41	MP0003693_abnormal_embryo_hatching	1.27176386
42	MP0008872_abnormal_physiological_respon	1.25988434
43	MP0003806_abnormal_nucleotide_metabolis	1.24010106
44	MP0001905_abnormal_dopamine_level	1.23033152
45	MP0009250_abnormal_appendicular_skeleto	1.22782430
46	MP0009053_abnormal_anal_canal	1.19818129
47	MP0003938_abnormal_ear_development	1.19352624
48	MP0002234_abnormal_pharynx_morphology	1.18317623
49	MP0003787_abnormal_imprinting	1.17923227
50	MP0002095_abnormal_skin_pigmentation	1.15544766
51	MP0001986_abnormal_taste_sensitivity	1.13971932
52	MP0001764_abnormal_homeostasis	1.08839701
53	MP0005551_abnormal_eye_electrophysiolog	1.06856251
54	MP0006276_abnormal_autonomic_nervous	1.05928255
55	MP0004742_abnormal_vestibular_system	1.05330354
56	MP0002132_abnormal_respiratory_system	1.02814052
57	MP0003195_calcinosis	0.99357786
58	MP0005195_abnormal_posterior_eye	0.98435656
59	MP0002210_abnormal_sex_determination	0.98225734
60	MP0000026_abnormal_inner_ear	0.96407948
61	MP0000372_irregular_coat_pigmentation	0.96168054
62	MP0002249_abnormal_larynx_morphology	0.94544414
63	MP0004858_abnormal_nervous_system	0.92092408
64	MP0005645_abnormal_hypothalamus_physiol	0.91846038
65	MP0008877_abnormal_DNA_methylation	0.90336087
66	MP0000778_abnormal_nervous_system	0.89823498
67	MP0002736_abnormal_nociception_after	0.89483792
68	MP0005670_abnormal_white_adipose	0.88269901
69	MP0002938_white_spotting	0.87145974
70	MP0001968_abnormal_touch/_nociception	0.86941247
71	MP0009745_abnormal_behavioral_response	0.86079720
72	MP0001502_abnormal_circadian_rhythm	0.84153902
73	MP0003880_abnormal_central_pattern	0.83852521
74	MP0003936_abnormal_reproductive_system	0.81956583
75	MP0003136_yellow_coat_color	0.80669808
76	MP0001145_abnormal_male_reproductive	0.79563467
77	MP0001119_abnormal_female_reproductive	0.79496956
78	MP0003119_abnormal_digestive_system	0.77562201
79	MP0005253_abnormal_eye_physiology	0.77178218
80	MP0002752_abnormal_somatic_nervous	0.76911174
81	MP0002184_abnormal_innervation	0.75671766
82	MP0002233_abnormal_nose_morphology	0.74363318
83	MP0003937_abnormal_limbs/digits/tail_de	0.73614481
84	MP0003786_premature_aging	0.73513868
85	MP0005174_abnormal_tail_pigmentation	0.73374311
86	MP0000653_abnormal_sex_gland	0.72849437
87	MP0000750_abnormal_muscle_regeneration	0.72803080
88	MP0001286_abnormal_eye_development	0.72558065
89	MP0001727_abnormal_embryo_implantation	0.71749232
90	MP0001348_abnormal_lacrimal_gland	0.71696327
91	MP0003121_genomic_imprinting	0.71075312
92	MP0003122_maternal_imprinting	0.68512350
93	MP0004147_increased_porphyrin_level	0.68504426
94	MP0001661_extended_life_span	0.68108581
95	MP0008995_early_reproductive_senescence	0.67234977
96	MP0005084_abnormal_gallbladder_morpholo	0.66348819
97	MP0002272_abnormal_nervous_system	0.66140382
98	MP0005391_vision/eye_phenotype	0.65157331
99	MP0000955_abnormal_spinal_cord	0.64952486
100	MP0003011_delayed_dark_adaptation	0.64638689

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.06408421
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.89982507
3	Reticulocytopenia (HP:0001896)	4.67692417
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.60576419
5	Mitochondrial inheritance (HP:0001427)	4.53691384
6	Macrocytic anemia (HP:0001972)	4.40207445
7	Acute encephalopathy (HP:0006846)	4.30392758
8	Increased CSF lactate (HP:0002490)	4.10172626
9	Progressive macrocephaly (HP:0004481)	3.94506082
10	Abnormal number of erythroid precursors (HP:0012131)	3.91884738
11	3-Methylglutaconic aciduria (HP:0003535)	3.71069297
12	Increased hepatocellular lipid droplets (HP:0006565)	3.63288646
13	Renal Fanconi syndrome (HP:0001994)	3.56254568
14	Hepatocellular necrosis (HP:0001404)	3.55122351
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.46531193
16	Cerebral edema (HP:0002181)	3.42315805
17	Hepatic necrosis (HP:0002605)	3.28003046
18	Pallor (HP:0000980)	3.27973466
19	Lipid accumulation in hepatocytes (HP:0006561)	3.27534274
20	Partial duplication of the phalanx of hand (HP:0009999)	3.18237403
21	Absent thumb (HP:0009777)	2.99017003
22	Abnormal rod and cone electroretinograms (HP:0008323)	2.90940155
23	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.90833444
24	Increased intramyocellular lipid droplets (HP:0012240)	2.83080461
25	Hyperglycinemia (HP:0002154)	2.81637933
26	Increased serum lactate (HP:0002151)	2.81398799
27	Hypoplasia of the radius (HP:0002984)	2.78781177
28	Partial duplication of thumb phalanx (HP:0009944)	2.76479661
29	Congenital stationary night blindness (HP:0007642)	2.75766789
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.73942243
31	Abnormality of alanine metabolism (HP:0010916)	2.64927906
32	Hyperalaninemia (HP:0003348)	2.64927906
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.64927906
34	Lactic acidosis (HP:0003128)	2.58199424
35	Optic disc pallor (HP:0000543)	2.55482970
36	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.52950640
37	Rib fusion (HP:0000902)	2.39906646
38	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.39471545
39	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.39471545
40	Microretrognathia (HP:0000308)	2.38954668
41	Respiratory difficulties (HP:0002880)	2.38396713
42	Abnormality of renal resorption (HP:0011038)	2.34916187
43	Increased muscle lipid content (HP:0009058)	2.31849276
44	Abnormality of midbrain morphology (HP:0002418)	2.28161754
45	Molar tooth sign on MRI (HP:0002419)	2.28161754
46	Triphalangeal thumb (HP:0001199)	2.25249161
47	Lethargy (HP:0001254)	2.20880438
48	Forearm undergrowth (HP:0009821)	2.20560156
49	Exercise intolerance (HP:0003546)	2.19561790
50	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.18816667
51	Septo-optic dysplasia (HP:0100842)	2.17780019
52	Pancreatic fibrosis (HP:0100732)	2.17687954
53	Exertional dyspnea (HP:0002875)	2.14251593
54	Leukodystrophy (HP:0002415)	2.14013471
55	Patent foramen ovale (HP:0001655)	2.12604391
56	Myokymia (HP:0002411)	2.12346345
57	Respiratory failure (HP:0002878)	2.08724006
58	Stenosis of the external auditory canal (HP:0000402)	2.08274204
59	Abnormality of urine glucose concentration (HP:0011016)	2.07062308
60	Glycosuria (HP:0003076)	2.07062308
61	Methylmalonic acidemia (HP:0002912)	2.05792738
62	Hyperphosphaturia (HP:0003109)	2.04437809
63	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.02428129
64	Pancreatic cysts (HP:0001737)	2.01508643
65	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.99735339
66	Pendular nystagmus (HP:0012043)	1.97867665
67	Abnormality of serum amino acid levels (HP:0003112)	1.97063427
68	Depressed nasal ridge (HP:0000457)	1.95011710
69	True hermaphroditism (HP:0010459)	1.94564288
70	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.94060639
71	Type II lissencephaly (HP:0007260)	1.90394161
72	Colon cancer (HP:0003003)	1.88665066
73	Hypoplasia of the ulna (HP:0003022)	1.84454916
74	Cleft eyelid (HP:0000625)	1.83260173
75	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.81874849
76	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.80582066
77	Absent/shortened dynein arms (HP:0200106)	1.80582066
78	Generalized aminoaciduria (HP:0002909)	1.79965893
79	Abnormality of the 2nd finger (HP:0004100)	1.78622197
80	Medial flaring of the eyebrow (HP:0010747)	1.78298230
81	Methylmalonic aciduria (HP:0012120)	1.78226000
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.77820037
83	Anencephaly (HP:0002323)	1.75802679
84	Deep palmar crease (HP:0006191)	1.75612339
85	Sclerocornea (HP:0000647)	1.75482523
86	Delayed CNS myelination (HP:0002188)	1.71785713
87	Abnormal ciliary motility (HP:0012262)	1.71348730
88	Dyskinesia (HP:0100660)	1.69648182
89	Abnormality of the middle phalanges of the toes (HP:0010183)	1.66735125
90	Muscle fiber atrophy (HP:0100295)	1.66541525
91	Renal tubular dysfunction (HP:0000124)	1.65449745
92	Constricted visual fields (HP:0001133)	1.65068096
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.64780991
94	Duplication of thumb phalanx (HP:0009942)	1.64742664
95	Aplastic anemia (HP:0001915)	1.64439189
96	Maternal diabetes (HP:0009800)	1.63617827
97	Paralysis (HP:0003470)	1.61882201
98	CNS demyelination (HP:0007305)	1.60236065
99	Dicarboxylic aciduria (HP:0003215)	1.59682889
100	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.59682889

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.31684859
2	BCKDK	3.30159012
3	NME2	3.07342069
4	STK16	2.84190357
5	CDK19	2.59477897
6	ZAK	2.54062174
7	TESK2	2.47178876
8	TXK	2.31829403
9	LIMK1	2.30082055
10	DYRK2	2.18298668
11	PDK2	2.09407577
12	VRK2	2.07833933
13	KDR	2.04297109
14	PASK	1.93087370
15	GRK1	1.84812994
16	BRAF	1.80972467
17	CDC7	1.80563180
18	ADRBK2	1.78341025
19	MAP4K2	1.75658708
20	LRRK2	1.74106398
21	WNK4	1.55061191
22	EIF2AK1	1.49431605
23	MAP3K13	1.47039029
24	NME1	1.45827745
25	VRK1	1.38542509
26	ARAF	1.36585539
27	CAMKK2	1.35254298
28	TAF1	1.32239480
29	ILK	1.28810776
30	PIK3CA	1.28594456
31	CDK8	1.24909028
32	ABL2	1.21682866
33	AURKA	1.21208424
34	BMPR1B	1.20568431
35	SCYL2	1.15779014
36	TESK1	1.12720705
37	PLK4	1.08188204
38	PIM2	1.05163686
39	TIE1	1.04745218
40	MAP3K11	1.00711971
41	PINK1	0.99896929
42	MAP2K6	0.99690539
43	PIK3CG	0.98560690
44	NEK1	0.98098883
45	CAMKK1	0.96747335
46	PRKCQ	0.93437831
47	MAP3K9	0.91782718
48	EPHB2	0.85361769
49	CSNK2A2	0.85009066
50	NEK2	0.84736225
51	NUAK1	0.84669640
52	BUB1	0.82624601
53	DAPK3	0.81991784
54	IKBKB	0.81223497
55	WNK3	0.80831801
56	SYK	0.76205967
57	PRKCG	0.75279814
58	ATR	0.74700315
59	PIM1	0.73657426
60	CSNK2A1	0.70878789
61	BRSK1	0.70753322
62	RPS6KA5	0.68309806
63	GRK7	0.66964229
64	MAP4K1	0.66872320
65	ADRBK1	0.66567958
66	AURKB	0.66223696
67	PLK1	0.64122264
68	TNK2	0.64041369
69	MUSK	0.63637888
70	INSRR	0.62380871
71	AKT2	0.59991635
72	CAMK1	0.59462196
73	OBSCN	0.58950940
74	LCK	0.57136851
75	PRKACA	0.54701778
76	MOS	0.54627264
77	PKN1	0.53790318
78	PRKCD	0.53547871
79	MAP2K7	0.51802494
80	DYRK1B	0.51736911
81	NTRK2	0.50838377
82	MARK3	0.49051959
83	ITK	0.47882709
84	RPS6KB2	0.47440418
85	TAOK3	0.47115542
86	CSNK1G3	0.45915474
87	PAK1	0.45271529
88	TNIK	0.41885084
89	TEC	0.41229242
90	RPS6KA6	0.40527753
91	STK39	0.40480449
92	PRKCA	0.39355634
93	MAPK15	0.38992079
94	STK11	0.38205697
95	BRSK2	0.37621870
96	SRPK1	0.37399828
97	MAPKAPK5	0.37376561
98	CHEK2	0.36190821
99	IRAK4	0.35984103
100	CDK11A	0.34371793

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.39707826
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.34094996
3	Parkinsons disease_Homo sapiens_hsa05012	3.86276713
4	Sulfur relay system_Homo sapiens_hsa04122	3.30507132
5	Huntingtons disease_Homo sapiens_hsa05016	2.61388691
6	Alzheimers disease_Homo sapiens_hsa05010	2.54990596
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.50425354
8	Proteasome_Homo sapiens_hsa03050	2.39479788
9	RNA polymerase_Homo sapiens_hsa03020	2.38858720
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.15336221
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.07500055
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.82382732
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.77917531
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.62801059
15	RNA degradation_Homo sapiens_hsa03018	1.60296233
16	DNA replication_Homo sapiens_hsa03030	1.56953985
17	Sulfur metabolism_Homo sapiens_hsa00920	1.53311858
18	Homologous recombination_Homo sapiens_hsa03440	1.49567092
19	One carbon pool by folate_Homo sapiens_hsa00670	1.43164494
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.40426686
21	Protein export_Homo sapiens_hsa03060	1.37714877
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30290410
23	Spliceosome_Homo sapiens_hsa03040	1.24549545
24	Phototransduction_Homo sapiens_hsa04744	1.22855172
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.21316896
26	Mismatch repair_Homo sapiens_hsa03430	1.19608074
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.18766721
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.14004155
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.10449597
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08526850
31	Basal transcription factors_Homo sapiens_hsa03022	1.06510500
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.01063819
33	Base excision repair_Homo sapiens_hsa03410	1.00940008
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93927311
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.93593830
36	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.92447899
37	Allograft rejection_Homo sapiens_hsa05330	0.92012254
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.90615326
39	Primary immunodeficiency_Homo sapiens_hsa05340	0.89959670
40	Caffeine metabolism_Homo sapiens_hsa00232	0.88899693
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.87560205
42	Asthma_Homo sapiens_hsa05310	0.86678874
43	Purine metabolism_Homo sapiens_hsa00230	0.85931406
44	RNA transport_Homo sapiens_hsa03013	0.85421745
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83646827
46	Peroxisome_Homo sapiens_hsa04146	0.80151301
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.79463351
48	Retinol metabolism_Homo sapiens_hsa00830	0.78487158
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76920111
50	Graft-versus-host disease_Homo sapiens_hsa05332	0.75473821
51	Metabolic pathways_Homo sapiens_hsa01100	0.75258548
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.74972581
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72959396
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72678789
55	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.71305696
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70727360
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.69602404
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.68123854
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67968146
60	Regulation of autophagy_Homo sapiens_hsa04140	0.66602619
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65416647
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63125743
63	Olfactory transduction_Homo sapiens_hsa04740	0.62837820
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.62398279
65	Propanoate metabolism_Homo sapiens_hsa00640	0.62246069
66	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.62078068
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61506691
68	Butanoate metabolism_Homo sapiens_hsa00650	0.60329437
69	Folate biosynthesis_Homo sapiens_hsa00790	0.59886166
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.58018859
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.56901890
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.55094471
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54116675
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51528210
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.51497042
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.51375202
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.50886619
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.50356522
79	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49297577
80	Glutathione metabolism_Homo sapiens_hsa00480	0.48422491
81	Fatty acid degradation_Homo sapiens_hsa00071	0.48093698
82	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47086698
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41892231
84	Antigen processing and presentation_Homo sapiens_hsa04612	0.39089763
85	Fatty acid elongation_Homo sapiens_hsa00062	0.37966511
86	Nicotine addiction_Homo sapiens_hsa05033	0.37287404
87	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.34852384
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34814374
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33190965
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.32975419
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.32688184
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26475263
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.24377412
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.22895192
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.21601205
96	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.19292071
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.17465791
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.17113267
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.13842505
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.11695757

RPS7P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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