RPS7P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.98403916
2DNA deamination (GO:0045006)6.67975280
3viral transcription (GO:0019083)6.17361023
4ribosomal small subunit biogenesis (GO:0042274)5.96718749
5translational termination (GO:0006415)5.90426471
6cytidine metabolic process (GO:0046087)5.63726143
7cytidine catabolic process (GO:0006216)5.63726143
8cytidine deamination (GO:0009972)5.63726143
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.52031593
10translational elongation (GO:0006414)5.23072816
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.20401992
12maturation of SSU-rRNA (GO:0030490)5.15493250
13cotranslational protein targeting to membrane (GO:0006613)5.12433202
14protein targeting to ER (GO:0045047)5.11260588
15ATP synthesis coupled proton transport (GO:0015986)5.10365584
16energy coupled proton transport, down electrochemical gradient (GO:0015985)5.10365584
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.07425393
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.86272471
19protein localization to endoplasmic reticulum (GO:0070972)4.82085591
20pyrimidine ribonucleoside catabolic process (GO:0046133)4.80580713
21viral life cycle (GO:0019058)4.49675327
22ribosomal large subunit biogenesis (GO:0042273)4.47303152
23cellular protein complex disassembly (GO:0043624)4.44584775
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.30500580
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.25139004
26translational initiation (GO:0006413)4.10328416
27respiratory electron transport chain (GO:0022904)4.04938130
28electron transport chain (GO:0022900)4.02142050
29protein complex biogenesis (GO:0070271)3.90793039
30chaperone-mediated protein transport (GO:0072321)3.82875005
31translation (GO:0006412)3.81488573
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.71704032
33protein neddylation (GO:0045116)3.67599746
34protein complex disassembly (GO:0043241)3.61697526
35mitochondrial respiratory chain complex assembly (GO:0033108)3.53865042
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.53352912
37NADH dehydrogenase complex assembly (GO:0010257)3.53352912
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.53352912
39macromolecular complex disassembly (GO:0032984)3.44220635
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43825845
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43825845
42purine deoxyribonucleotide catabolic process (GO:0009155)3.38267410
43proteasome assembly (GO:0043248)3.31350338
44protein targeting to membrane (GO:0006612)3.31286442
45ribonucleoprotein complex biogenesis (GO:0022613)3.30869048
46cellular component biogenesis (GO:0044085)3.28503853
47purine nucleotide salvage (GO:0032261)3.25415960
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25132017
49platelet dense granule organization (GO:0060155)3.24835986
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.22960712
51base-excision repair, AP site formation (GO:0006285)3.19999159
52nuclear-transcribed mRNA catabolic process (GO:0000956)3.12673630
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12139272
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09878567
55metallo-sulfur cluster assembly (GO:0031163)3.09350699
56iron-sulfur cluster assembly (GO:0016226)3.09350699
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07069582
58behavioral response to nicotine (GO:0035095)3.05444143
59pseudouridine synthesis (GO:0001522)3.05126538
60deoxyribonucleotide catabolic process (GO:0009264)3.03831712
61actin nucleation (GO:0045010)2.99678340
62regulation of activation of Janus kinase activity (GO:0010533)2.99613534
63positive regulation of T cell apoptotic process (GO:0070234)2.99154892
64ATP biosynthetic process (GO:0006754)2.92980225
65mRNA catabolic process (GO:0006402)2.92267214
66response to pheromone (GO:0019236)2.90385367
67deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.88661408
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86344938
69deoxyribose phosphate catabolic process (GO:0046386)2.85539310
70purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.83655010
71positive thymic T cell selection (GO:0045059)2.82345579
72ubiquinone biosynthetic process (GO:0006744)2.79198917
73negative regulation of T cell apoptotic process (GO:0070233)2.77517235
74cytochrome complex assembly (GO:0017004)2.77342469
75rRNA processing (GO:0006364)2.75401490
76negative regulation of mast cell activation (GO:0033004)2.75072458
77pyrimidine nucleoside catabolic process (GO:0046135)2.72053958
78positive regulation of calcium-mediated signaling (GO:0050850)2.71748562
79rRNA metabolic process (GO:0016072)2.70457416
80respiratory chain complex IV assembly (GO:0008535)2.70150402
81positive T cell selection (GO:0043368)2.69952698
82sequestering of actin monomers (GO:0042989)2.69527101
83RNA catabolic process (GO:0006401)2.68483956
84hydrogen ion transmembrane transport (GO:1902600)2.66585267
85ncRNA 3-end processing (GO:0043628)2.66481026
86regulation of cellular amino acid metabolic process (GO:0006521)2.63667706
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62844333
88negative regulation by host of viral transcription (GO:0043922)2.61484669
89male meiosis I (GO:0007141)2.61354716
90regulation of regulatory T cell differentiation (GO:0045589)2.61274325
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61231814
92pyrimidine ribonucleoside metabolic process (GO:0046131)2.60069546
93GTP biosynthetic process (GO:0006183)2.54125164
94ribonucleoside triphosphate biosynthetic process (GO:0009201)2.53291949
95cytolysis (GO:0019835)2.52626322
96purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.51904550
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50604824
98protein targeting to mitochondrion (GO:0006626)2.50422621
99purine deoxyribonucleotide metabolic process (GO:0009151)2.50302115
100nucleotide salvage (GO:0043173)2.49644142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.81922770
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.36146987
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.59316270
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49717652
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.45365988
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19649933
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90489826
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.81485063
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73979425
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.65469111
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65440028
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55565092
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.42929164
14VDR_23849224_ChIP-Seq_CD4+_Human2.39358095
15ZNF274_21170338_ChIP-Seq_K562_Hela2.18577374
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16812251
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.03438093
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03044939
19FOXP3_21729870_ChIP-Seq_TREG_Human2.01880728
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99522470
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94242972
22EZH2_22144423_ChIP-Seq_EOC_Human1.92450352
23IGF1R_20145208_ChIP-Seq_DFB_Human1.92315929
24VDR_22108803_ChIP-Seq_LS180_Human1.87726309
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.83752791
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72308363
27MYC_18940864_ChIP-ChIP_HL60_Human1.71188883
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.64403605
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60713572
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57160003
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54295555
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52478206
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49766032
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49003340
35ELK1_19687146_ChIP-ChIP_HELA_Human1.48007962
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47460241
37TP53_22573176_ChIP-Seq_HFKS_Human1.42423930
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40854022
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38935078
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38854312
41MYB_26560356_Chip-Seq_TH2_Human1.36940272
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36929020
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34964628
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34069764
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32329795
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30609639
47TTF2_22483619_ChIP-Seq_HELA_Human1.30131981
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29878448
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.29544883
50TAF2_19829295_ChIP-Seq_ESCs_Human1.27938813
51AR_20517297_ChIP-Seq_VCAP_Human1.24660716
52EWS_26573619_Chip-Seq_HEK293_Human1.23367715
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.23174103
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23174103
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22846328
56NCOR_22424771_ChIP-Seq_293T_Human1.21728352
57PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21633857
58NANOG_20526341_ChIP-Seq_ESCs_Human1.20564206
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20344412
60GATA3_26560356_Chip-Seq_TH2_Human1.18869434
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.18598313
62FUS_26573619_Chip-Seq_HEK293_Human1.18590779
63BCL6_27268052_Chip-Seq_Bcells_Human1.16662130
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.15813615
65XRN2_22483619_ChIP-Seq_HELA_Human1.15107900
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15052375
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13066339
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.13042662
69IRF1_19129219_ChIP-ChIP_H3396_Human1.12008921
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09687850
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09174523
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08192263
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.06386677
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.03789467
75GABP_19822575_ChIP-Seq_HepG2_Human1.03489833
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03058676
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02732638
78ERG_20517297_ChIP-Seq_VCAP_Human1.01720532
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01226168
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01044411
81NANOG_19829295_ChIP-Seq_ESCs_Human1.00680480
82SOX2_19829295_ChIP-Seq_ESCs_Human1.00680480
83MYC_19829295_ChIP-Seq_ESCs_Human1.00588495
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00356620
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99962992
86GATA3_27048872_Chip-Seq_THYMUS_Human0.98309823
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98008660
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97036401
89CTCF_20526341_ChIP-Seq_ESCs_Human0.96831288
90ERA_21632823_ChIP-Seq_H3396_Human0.96665458
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96139327
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96006362
93HTT_18923047_ChIP-ChIP_STHdh_Human0.95847495
94MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94877963
95MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93125187
96DCP1A_22483619_ChIP-Seq_HELA_Human0.92760702
97P53_21459846_ChIP-Seq_SAOS-2_Human0.91725959
98P300_27268052_Chip-Seq_Bcells_Human0.91470745
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.87064382
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86552930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.17198227
2MP0005671_abnormal_response_to3.78156204
3MP0006292_abnormal_olfactory_placode2.80307334
4MP0005646_abnormal_pituitary_gland2.39947398
5MP0001835_abnormal_antigen_presentation2.20562760
6MP0002163_abnormal_gland_morphology2.16878319
7MP0009333_abnormal_splenocyte_physiolog2.14993946
8MP0004147_increased_porphyrin_level2.07266658
9MP0003646_muscle_fatigue2.04562540
10MP0000372_irregular_coat_pigmentation2.03823659
11MP0003763_abnormal_thymus_physiology1.99502020
12MP0002837_dystrophic_cardiac_calcinosis1.97042413
13MP0009785_altered_susceptibility_to1.94210184
14MP0002102_abnormal_ear_morphology1.89297998
15MP0003806_abnormal_nucleotide_metabolis1.88829152
16MP0005645_abnormal_hypothalamus_physiol1.87318129
17MP0008872_abnormal_physiological_respon1.75551800
18MP0008875_abnormal_xenobiotic_pharmacok1.70104398
19MP0002160_abnormal_reproductive_system1.67631902
20MP0002138_abnormal_hepatobiliary_system1.66935668
21MP0002148_abnormal_hypersensitivity_rea1.65980220
22MP0005551_abnormal_eye_electrophysiolog1.64620411
23MP0001764_abnormal_homeostasis1.61886614
24MP0002638_abnormal_pupillary_reflex1.59941672
25MP0001968_abnormal_touch/_nociception1.58306560
26MP0005389_reproductive_system_phenotype1.57778061
27MP0006072_abnormal_retinal_apoptosis1.56026799
28MP0001800_abnormal_humoral_immune1.55728259
29MP0004142_abnormal_muscle_tone1.46907401
30MP0005000_abnormal_immune_tolerance1.44104435
31MP0002420_abnormal_adaptive_immunity1.43228090
32MP0002736_abnormal_nociception_after1.39077311
33MP0005075_abnormal_melanosome_morpholog1.38896781
34MP0001819_abnormal_immune_cell1.38249502
35MP0003786_premature_aging1.38054441
36MP0001188_hyperpigmentation1.37929729
37MP0001919_abnormal_reproductive_system1.37686800
38MP0002723_abnormal_immune_serum1.37395444
39MP0006276_abnormal_autonomic_nervous1.37274619
40MP0005025_abnormal_response_to1.33967393
41MP0004145_abnormal_muscle_electrophysio1.33817239
42MP0001905_abnormal_dopamine_level1.33152069
43MP0002095_abnormal_skin_pigmentation1.29919100
44MP0005379_endocrine/exocrine_gland_phen1.29297323
45MP0006036_abnormal_mitochondrial_physio1.29086489
46MP0008877_abnormal_DNA_methylation1.28266026
47MP0005084_abnormal_gallbladder_morpholo1.26774111
48MP0002876_abnormal_thyroid_physiology1.23768447
49MP0002277_abnormal_respiratory_mucosa1.20306600
50MP0005083_abnormal_biliary_tract1.20306289
51MP0003878_abnormal_ear_physiology1.19966768
52MP0005377_hearing/vestibular/ear_phenot1.19966768
53MP0002398_abnormal_bone_marrow1.18285277
54MP0000716_abnormal_immune_system1.18219319
55MP0000685_abnormal_immune_system1.16566417
56MP0003252_abnormal_bile_duct1.13263661
57MP0005387_immune_system_phenotype1.12992063
58MP0001790_abnormal_immune_system1.12992063
59MP0003567_abnormal_fetal_cardiomyocyte1.12707558
60MP0008058_abnormal_DNA_repair1.11487910
61MP0002452_abnormal_antigen_presenting1.09320587
62MP0005253_abnormal_eye_physiology1.08409646
63MP0001873_stomach_inflammation1.07647219
64MP0002166_altered_tumor_susceptibility1.06923524
65MP0008789_abnormal_olfactory_epithelium1.06069570
66MP0004885_abnormal_endolymph1.04134812
67MP0005174_abnormal_tail_pigmentation1.00402328
68MP0002006_tumorigenesis0.99830159
69MP0002234_abnormal_pharynx_morphology0.96294148
70MP0005636_abnormal_mineral_homeostasis0.96260224
71MP0000703_abnormal_thymus_morphology0.96161316
72MP0003866_abnormal_defecation0.95600899
73MP0008995_early_reproductive_senescence0.95123284
74MP0000689_abnormal_spleen_morphology0.94021994
75MP0002429_abnormal_blood_cell0.91927349
76MP0002405_respiratory_system_inflammati0.91278999
77MP0002272_abnormal_nervous_system0.90271631
78MP0005410_abnormal_fertilization0.89599148
79MP0001986_abnormal_taste_sensitivity0.89339871
80MP0003186_abnormal_redox_activity0.88625044
81MP0000049_abnormal_middle_ear0.87862250
82MP0002132_abnormal_respiratory_system0.87076193
83MP0000631_abnormal_neuroendocrine_gland0.85404850
84MP0002722_abnormal_immune_system0.85105757
85MP0002733_abnormal_thermal_nociception0.82812106
86MP0006082_CNS_inflammation0.81442914
87MP0005085_abnormal_gallbladder_physiolo0.81174270
88MP0003011_delayed_dark_adaptation0.79274501
89MP0001485_abnormal_pinna_reflex0.77396856
90MP0003787_abnormal_imprinting0.75652015
91MP0009745_abnormal_behavioral_response0.75167845
92MP0003195_calcinosis0.73685008
93MP0010386_abnormal_urinary_bladder0.72086753
94MP0005464_abnormal_platelet_physiology0.71730381
95MP0010155_abnormal_intestine_physiology0.71254082
96MP0002653_abnormal_ependyma_morphology0.70567119
97MP0009643_abnormal_urine_homeostasis0.69325779
98MP0001845_abnormal_inflammatory_respons0.69078540
99MP0001970_abnormal_pain_threshold0.68879707
100MP0009764_decreased_sensitivity_to0.68783978

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.53805735
2Mitochondrial inheritance (HP:0001427)4.39200324
3Abnormal mitochondria in muscle tissue (HP:0008316)4.25586879
4Congenital stationary night blindness (HP:0007642)4.13075443
53-Methylglutaconic aciduria (HP:0003535)4.03226778
6Aplastic anemia (HP:0001915)3.82966285
7Increased CSF lactate (HP:0002490)3.81054391
8Reticulocytopenia (HP:0001896)3.76165050
9Acute encephalopathy (HP:0006846)3.74945636
10Increased hepatocellular lipid droplets (HP:0006565)3.69812600
11Progressive macrocephaly (HP:0004481)3.67588306
12Increased intramyocellular lipid droplets (HP:0012240)3.67473390
13Abnormality of cells of the erythroid lineage (HP:0012130)3.52621215
14Hepatocellular necrosis (HP:0001404)3.39237345
15Renal Fanconi syndrome (HP:0001994)3.26411843
16Abnormal number of erythroid precursors (HP:0012131)3.22411847
17Macrocytic anemia (HP:0001972)3.21742259
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21374612
19Lipid accumulation in hepatocytes (HP:0006561)3.21117730
20Hepatic necrosis (HP:0002605)3.09621767
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08966729
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08966729
23Cerebral edema (HP:0002181)3.04397326
24Elevated erythrocyte sedimentation rate (HP:0003565)2.98915920
25Increased muscle lipid content (HP:0009058)2.96609483
26Abnormal rod and cone electroretinograms (HP:0008323)2.94658648
27Pancreatic cysts (HP:0001737)2.91795614
28Severe combined immunodeficiency (HP:0004430)2.91722308
29IgG deficiency (HP:0004315)2.90948421
30Autoimmune hemolytic anemia (HP:0001890)2.77631560
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.73817919
32Pallor (HP:0000980)2.68311244
33Abnormality of midbrain morphology (HP:0002418)2.67246373
34Molar tooth sign on MRI (HP:0002419)2.67246373
35Optic disc pallor (HP:0000543)2.63486253
36Pancreatic fibrosis (HP:0100732)2.57471490
37True hermaphroditism (HP:0010459)2.56745641
38Exertional dyspnea (HP:0002875)2.55376017
39Lactic acidosis (HP:0003128)2.52207266
40Increased serum lactate (HP:0002151)2.48888958
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46248681
42Hypoproteinemia (HP:0003075)2.43634950
43Abnormality of the prostate (HP:0008775)2.35522116
44Abnormality of T cell number (HP:0011839)2.33636248
45Respiratory difficulties (HP:0002880)2.32151314
46Increased IgM level (HP:0003496)2.31674341
47T lymphocytopenia (HP:0005403)2.29324586
48Abnormality of the renal cortex (HP:0011035)2.26170206
49Pancytopenia (HP:0001876)2.25051026
50Abnormality of B cell number (HP:0010975)2.23625639
51Abolished electroretinogram (ERG) (HP:0000550)2.23008905
52Abnormality of T cells (HP:0002843)2.21239444
53Glycosuria (HP:0003076)2.20637278
54Abnormality of urine glucose concentration (HP:0011016)2.20637278
55Panhypogammaglobulinemia (HP:0003139)2.18563173
56Hyperphosphaturia (HP:0003109)2.17765294
57Respiratory failure (HP:0002878)2.17461150
58Stenosis of the external auditory canal (HP:0000402)2.17394785
59Absent thumb (HP:0009777)2.17038450
60Exercise intolerance (HP:0003546)2.14332347
61Testicular atrophy (HP:0000029)2.13563273
62Combined immunodeficiency (HP:0005387)2.11109024
63Severe visual impairment (HP:0001141)2.10900392
64Abnormality of renal resorption (HP:0011038)2.10593055
65Lethargy (HP:0001254)2.09000402
66Attenuation of retinal blood vessels (HP:0007843)2.05690906
67Abnormality of DNA repair (HP:0003254)2.05456375
68Nephronophthisis (HP:0000090)2.04997300
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04641793
70Thyroiditis (HP:0100646)2.03252961
71Agammaglobulinemia (HP:0004432)1.98165732
72Renal cortical cysts (HP:0000803)1.97921219
73Stomatitis (HP:0010280)1.97901482
74Methylmalonic aciduria (HP:0012120)1.95548690
75Pendular nystagmus (HP:0012043)1.95151987
76Type 2 muscle fiber atrophy (HP:0003554)1.93024951
77Sclerocornea (HP:0000647)1.93021099
78Medial flaring of the eyebrow (HP:0010747)1.92943862
79Decreased central vision (HP:0007663)1.92713666
80Hypoplasia of the uterus (HP:0000013)1.91208226
81B lymphocytopenia (HP:0010976)1.89903371
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.89161896
83Polydipsia (HP:0001959)1.88984666
84Abnormal drinking behavior (HP:0030082)1.88984666
85Methylmalonic acidemia (HP:0002912)1.87679522
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86923180
87Dicarboxylic aciduria (HP:0003215)1.86923180
88Abnormality of eosinophils (HP:0001879)1.86699423
89Aplasia/hypoplasia of the uterus (HP:0008684)1.86317766
90Ketosis (HP:0001946)1.86033485
91Abnormality of the renal collecting system (HP:0004742)1.85234042
92Generalized aminoaciduria (HP:0002909)1.83298087
93Constricted visual fields (HP:0001133)1.83035944
94Type I transferrin isoform profile (HP:0003642)1.81999935
95Asplenia (HP:0001746)1.81895379
96Hyperglycinemia (HP:0002154)1.81273021
97Encephalitis (HP:0002383)1.81152418
98Prostate neoplasm (HP:0100787)1.80607507
99Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80412999
100Leukodystrophy (HP:0002415)1.78373873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.10383472
2KDR4.10125010
3TXK3.46096831
4VRK22.93080033
5BCKDK2.90893010
6ADRBK22.73054831
7GRK12.66863272
8MAP4K22.60668510
9ZAK2.29944430
10TIE12.21080518
11CDK192.08242457
12TAOK32.05326133
13MAP4K12.02955947
14STK161.95798787
15TLK11.93124638
16VRK11.86439717
17LIMK11.81702136
18ITK1.80575769
19NUAK11.74514862
20TEC1.65987502
21NME21.64057939
22MAP3K111.56089754
23MAP3K121.54277918
24SCYL21.50560969
25WNK41.42867865
26PASK1.39187287
27SYK1.38545538
28CAMKK21.36302388
29PINK11.31985486
30FES1.26039248
31PRKCQ1.09119467
32BUB11.06212715
33DAPK11.02462898
34INSRR0.99959262
35GRK60.99522543
36CCNB10.96892164
37TNK20.93657918
38AURKA0.90875513
39IKBKB0.88603533
40DYRK20.88049028
41BMPR1B0.87528532
42BTK0.85893677
43KIT0.82412531
44MST40.81601079
45FRK0.80777589
46LCK0.80103613
47ADRBK10.78012504
48PIM10.77421765
49TESK10.72615596
50LYN0.69756366
51GRK70.69450093
52PIK3CA0.68261182
53LRRK20.68020506
54MAP2K60.63927626
55CSF1R0.63082193
56PLK40.62991628
57IKBKE0.62940476
58WNK30.62468544
59OBSCN0.61435109
60RPS6KA50.60943973
61CDC70.59901343
62NME10.59470849
63CAMKK10.59319036
64DAPK20.58805642
65PIM20.58750828
66PDK20.58290737
67TAF10.57960530
68MYLK0.57127684
69CAMK10.54932292
70RPS6KA40.53332723
71CSNK1G30.52776200
72CSNK2A10.51667165
73CSNK2A20.50906081
74ABL20.50664343
75OXSR10.50347273
76DAPK30.47589986
77PRKACA0.46166506
78ATR0.45985430
79BMPR20.45772130
80PRKCA0.44605440
81CSK0.43871543
82MUSK0.42488988
83SRPK10.42330776
84MAPK130.41942667
85ZAP700.40994697
86CDK80.40339439
87IGF1R0.40128447
88CSNK1G20.39423178
89GRK50.39059630
90PRKCH0.38587715
91BRSK20.38480138
92MAP2K70.38177067
93MAPKAPK30.37549955
94MATK0.37415568
95PLK10.35581208
96STK390.34486865
97AURKB0.34479044
98ILK0.33517371
99MAPK150.33199527
100RPS6KA60.32180553

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.47539433
2Oxidative phosphorylation_Homo sapiens_hsa001903.97049802
3Proteasome_Homo sapiens_hsa030503.64977272
4Primary immunodeficiency_Homo sapiens_hsa053403.53365925
5Parkinsons disease_Homo sapiens_hsa050123.31893522
6Alzheimers disease_Homo sapiens_hsa050102.21617586
7Huntingtons disease_Homo sapiens_hsa050162.14690857
8Graft-versus-host disease_Homo sapiens_hsa053322.04583873
9RNA polymerase_Homo sapiens_hsa030202.03152939
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03045482
11Allograft rejection_Homo sapiens_hsa053302.01209774
12Autoimmune thyroid disease_Homo sapiens_hsa053201.96763132
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88845723
14Cardiac muscle contraction_Homo sapiens_hsa042601.79521813
15Caffeine metabolism_Homo sapiens_hsa002321.72636015
16Phototransduction_Homo sapiens_hsa047441.71931917
17Asthma_Homo sapiens_hsa053101.67517553
18Type I diabetes mellitus_Homo sapiens_hsa049401.66826062
19Protein export_Homo sapiens_hsa030601.65951455
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65863712
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61848781
22Homologous recombination_Homo sapiens_hsa034401.58910674
23Antigen processing and presentation_Homo sapiens_hsa046121.57444326
24Hematopoietic cell lineage_Homo sapiens_hsa046401.45807037
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.44388942
26Linoleic acid metabolism_Homo sapiens_hsa005911.43315250
27Fanconi anemia pathway_Homo sapiens_hsa034601.42998463
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39074811
29Pyrimidine metabolism_Homo sapiens_hsa002401.38305340
30DNA replication_Homo sapiens_hsa030301.23677352
31RNA degradation_Homo sapiens_hsa030181.22999257
32One carbon pool by folate_Homo sapiens_hsa006701.19473962
33Nitrogen metabolism_Homo sapiens_hsa009101.15365145
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14976398
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10353104
36Peroxisome_Homo sapiens_hsa041461.08836763
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07795289
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06099993
39Rheumatoid arthritis_Homo sapiens_hsa053231.04395660
40Nucleotide excision repair_Homo sapiens_hsa034201.02487422
41Base excision repair_Homo sapiens_hsa034101.00789746
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93972058
43Purine metabolism_Homo sapiens_hsa002300.93148550
44Retinol metabolism_Homo sapiens_hsa008300.92787733
45Mismatch repair_Homo sapiens_hsa034300.91566484
46Propanoate metabolism_Homo sapiens_hsa006400.89747023
47Sulfur relay system_Homo sapiens_hsa041220.87961810
48Basal transcription factors_Homo sapiens_hsa030220.87472256
49Chemical carcinogenesis_Homo sapiens_hsa052040.87100080
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.86919414
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.85685841
52T cell receptor signaling pathway_Homo sapiens_hsa046600.85358085
53Butanoate metabolism_Homo sapiens_hsa006500.84455588
54Olfactory transduction_Homo sapiens_hsa047400.83633896
55Spliceosome_Homo sapiens_hsa030400.81465568
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77594446
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77486989
58Arachidonic acid metabolism_Homo sapiens_hsa005900.75308360
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74920251
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72283515
61Tryptophan metabolism_Homo sapiens_hsa003800.71230099
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69425309
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69035357
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65642825
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.65416939
66Selenocompound metabolism_Homo sapiens_hsa004500.64107247
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63706166
68Metabolic pathways_Homo sapiens_hsa011000.63080366
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62747946
70RNA transport_Homo sapiens_hsa030130.59305998
71Sulfur metabolism_Homo sapiens_hsa009200.57351704
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56580405
73Regulation of autophagy_Homo sapiens_hsa041400.56025670
74Systemic lupus erythematosus_Homo sapiens_hsa053220.55099928
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49383653
76Nicotine addiction_Homo sapiens_hsa050330.48314526
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.47760884
78Viral myocarditis_Homo sapiens_hsa054160.46021520
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45977180
80Malaria_Homo sapiens_hsa051440.45421559
81Fat digestion and absorption_Homo sapiens_hsa049750.43761601
82Taste transduction_Homo sapiens_hsa047420.40313877
83Ether lipid metabolism_Homo sapiens_hsa005650.39973648
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39410269
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39296712
86Collecting duct acid secretion_Homo sapiens_hsa049660.39232843
87Folate biosynthesis_Homo sapiens_hsa007900.36455022
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35196876
89Measles_Homo sapiens_hsa051620.33235361
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30936154
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.30288792
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.29868739
93Pyruvate metabolism_Homo sapiens_hsa006200.28941561
94Staphylococcus aureus infection_Homo sapiens_hsa051500.26808939
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22532026
96Glutathione metabolism_Homo sapiens_hsa004800.20557809
97beta-Alanine metabolism_Homo sapiens_hsa004100.16383016
98Tyrosine metabolism_Homo sapiens_hsa003500.15615036
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15070431
100Mineral absorption_Homo sapiens_hsa049780.15030936

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