ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.72123069
2	ribosomal small subunit biogenesis (GO:0042274)	7.52425003
3	translational termination (GO:0006415)	7.41815463
4	ribosomal small subunit assembly (GO:0000028)	7.17711839
5	chaperone-mediated protein transport (GO:0072321)	6.87080534
6	translational elongation (GO:0006414)	6.65063331
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.21085036
8	cotranslational protein targeting to membrane (GO:0006613)	6.10416974
9	protein targeting to ER (GO:0045047)	6.09450372
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.80581234
11	protein localization to endoplasmic reticulum (GO:0070972)	5.70097777
12	cellular protein complex disassembly (GO:0043624)	5.67026325
13	maturation of SSU-rRNA (GO:0030490)	5.56733785
14	viral life cycle (GO:0019058)	5.51628596
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.31677996
16	ATP synthesis coupled proton transport (GO:0015986)	5.31677996
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.22039564
18	response to gravity (GO:0009629)	5.19157779
19	DNA deamination (GO:0045006)	5.14416543
20	translational initiation (GO:0006413)	4.92459425
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.71088021
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.71088021
23	protein complex disassembly (GO:0043241)	4.66326093
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.51421171
25	behavioral response to nicotine (GO:0035095)	4.49904721
26	macromolecular complex disassembly (GO:0032984)	4.38382531
27	protein complex biogenesis (GO:0070271)	4.38279442
28	translation (GO:0006412)	4.30006507
29	striated muscle atrophy (GO:0014891)	4.15593383
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.07432488
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.07432488
32	NADH dehydrogenase complex assembly (GO:0010257)	4.07432488
33	protein targeting to membrane (GO:0006612)	4.07364305
34	cytidine deamination (GO:0009972)	4.05144766
35	cytidine metabolic process (GO:0046087)	4.05144766
36	cytidine catabolic process (GO:0006216)	4.05144766
37	response to muscle activity (GO:0014850)	4.02758077
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.97245508
39	negative regulation of muscle hypertrophy (GO:0014741)	3.93733534
40	muscle atrophy (GO:0014889)	3.91964166
41	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.91559944
42	protein neddylation (GO:0045116)	3.87496069
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.79625535
44	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.71255055
45	cellular component biogenesis (GO:0044085)	3.71174382
46	skeletal muscle tissue regeneration (GO:0043403)	3.69466079
47	ribosomal large subunit biogenesis (GO:0042273)	3.66818679
48	ribonucleoprotein complex biogenesis (GO:0022613)	3.58406946
49	skeletal muscle adaptation (GO:0043501)	3.50394888
50	mRNA catabolic process (GO:0006402)	3.46410288
51	respiratory electron transport chain (GO:0022904)	3.44317838
52	electron transport chain (GO:0022900)	3.43999867
53	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.42803246
54	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.41464703
55	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.19387319
56	actin-myosin filament sliding (GO:0033275)	3.17610263
57	muscle filament sliding (GO:0030049)	3.17610263
58	nucleotide salvage (GO:0043173)	3.13925781
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13726885
60	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.11494090
61	ATP biosynthetic process (GO:0006754)	3.11310262
62	RNA catabolic process (GO:0006401)	3.09183538
63	CTP metabolic process (GO:0046036)	3.08773383
64	CTP biosynthetic process (GO:0006241)	3.08773383
65	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.06240064
66	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.05581893
67	rRNA processing (GO:0006364)	3.01583608
68	cell proliferation in forebrain (GO:0021846)	2.98891897
69	water-soluble vitamin biosynthetic process (GO:0042364)	2.98157029
70	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.97373616
71	purine nucleotide salvage (GO:0032261)	2.96926223
72	protein polyglutamylation (GO:0018095)	2.96157505
73	rRNA metabolic process (GO:0016072)	2.93486084
74	GTP biosynthetic process (GO:0006183)	2.90184437
75	cellular response to dexamethasone stimulus (GO:0071549)	2.83460460
76	regulation of skeletal muscle contraction (GO:0014819)	2.79234876
77	hydrogen ion transmembrane transport (GO:1902600)	2.77544298
78	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.76469013
79	protein-cofactor linkage (GO:0018065)	2.74826046
80	cytochrome complex assembly (GO:0017004)	2.74123830
81	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.70749212
82	base-excision repair, AP site formation (GO:0006285)	2.70051998
83	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.67951808
84	regulation of activation of Janus kinase activity (GO:0010533)	2.66081299
85	regulation of isotype switching to IgG isotypes (GO:0048302)	2.65293488
86	outer ear morphogenesis (GO:0042473)	2.65187717
87	positive regulation of T cell apoptotic process (GO:0070234)	2.64087158
88	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.62111262
89	establishment of protein localization to membrane (GO:0090150)	2.62095575
90	response to dexamethasone (GO:0071548)	2.61034395
91	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.58209862
92	pyrimidine nucleotide catabolic process (GO:0006244)	2.58160299
93	positive regulation of prostaglandin secretion (GO:0032308)	2.56612617
94	nucleoside triphosphate biosynthetic process (GO:0009142)	2.55301490
95	protein targeting (GO:0006605)	2.54757620
96	respiratory chain complex IV assembly (GO:0008535)	2.54585898
97	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.53686114
98	protein targeting to mitochondrion (GO:0006626)	2.51263949
99	proton transport (GO:0015992)	2.50554323
100	pseudouridine synthesis (GO:0001522)	2.49564673

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.69049004
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.71817667
3	VDR_22108803_ChIP-Seq_LS180_Human	4.14083319
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.61975334
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.16731914
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.02376723
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.41484208
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41093497
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.40169609
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.30087770
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.28304523
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28287135
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.26077473
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.05432238
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.98672198
16	ZNF274_21170338_ChIP-Seq_K562_Hela	1.98289568
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.90798643
18	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.87370680
19	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.79523278
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.74111195
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74080063
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.74033057
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72085486
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.70317771
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70263111
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.68483859
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67193518
28	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.66103148
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.66034493
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.60298643
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.57910889
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.53812065
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52678161
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52556085
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49497111
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47916056
37	FUS_26573619_Chip-Seq_HEK293_Human	1.47203094
38	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.38805532
39	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38044534
40	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.32081620
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.30106694
42	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.30098871
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28813417
44	NCOR_22424771_ChIP-Seq_293T_Human	1.28466713
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28127390
46	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27489837
47	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.26559128
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24964683
49	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.24904328
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24655944
51	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.23371995
52	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22090123
53	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20970192
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20373837
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17219950
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16520891
57	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15914883
58	XRN2_22483619_ChIP-Seq_HELA_Human	1.14556942
59	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12349540
60	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11903038
61	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11669038
62	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11584574
63	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.08415705
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08084506
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.07658082
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06870363
67	TTF2_22483619_ChIP-Seq_HELA_Human	1.06283022
68	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03929962
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.03794698
70	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.01325519
71	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01263654
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00973262
73	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00831590
74	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99811928
75	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99132967
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99118292
77	AR_20517297_ChIP-Seq_VCAP_Human	0.99097357
78	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98224975
79	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.97778317
80	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.97496620
81	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.97496620
82	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95772302
83	CTCF_20526341_ChIP-Seq_ESCs_Human	0.94972179
84	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.94654753
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.92716846
86	E2F1_20622854_ChIP-Seq_HELA_Human	0.91549937
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91465313
88	ERA_21632823_ChIP-Seq_H3396_Human	0.90709334
89	EWS_26573619_Chip-Seq_HEK293_Human	0.90636084
90	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.89314147
91	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.89141252
92	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.87991362
93	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.86689877
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.84801968
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84689070
96	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.83750802
97	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.83120323
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.82883846
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.82883846
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.82307490

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.38644283
2	MP0006292_abnormal_olfactory_placode	3.92237132
3	MP0003646_muscle_fatigue	3.65520212
4	MP0004145_abnormal_muscle_electrophysio	3.33521947
5	MP0002638_abnormal_pupillary_reflex	3.17702503
6	MP0002163_abnormal_gland_morphology	2.91839560
7	MP0005671_abnormal_response_to	2.34762786
8	MP0002837_dystrophic_cardiac_calcinosis	2.08887110
9	MP0002102_abnormal_ear_morphology	2.07481822
10	MP0001968_abnormal_touch/_nociception	2.06898989
11	MP0008789_abnormal_olfactory_epithelium	1.92611796
12	MP0000372_irregular_coat_pigmentation	1.88010389
13	MP0004142_abnormal_muscle_tone	1.82036366
14	MP0001905_abnormal_dopamine_level	1.78956772
15	MP0000049_abnormal_middle_ear	1.76028546
16	MP0002277_abnormal_respiratory_mucosa	1.72726262
17	MP0002095_abnormal_skin_pigmentation	1.69548545
18	MP0004885_abnormal_endolymph	1.66570335
19	MP0002736_abnormal_nociception_after	1.65379673
20	MP0005646_abnormal_pituitary_gland	1.59559330
21	MP0008872_abnormal_physiological_respon	1.57892991
22	MP0000566_synostosis	1.57014237
23	MP0008875_abnormal_xenobiotic_pharmacok	1.55329993
24	MP0005379_endocrine/exocrine_gland_phen	1.54699123
25	MP0006072_abnormal_retinal_apoptosis	1.49525455
26	MP0009333_abnormal_splenocyte_physiolog	1.38268283
27	MP0002234_abnormal_pharynx_morphology	1.37572219
28	MP0000631_abnormal_neuroendocrine_gland	1.36414302
29	MP0001529_abnormal_vocalization	1.35083911
30	MP0002160_abnormal_reproductive_system	1.35010733
31	MP0000747_muscle_weakness	1.32297542
32	MP0003878_abnormal_ear_physiology	1.29182249
33	MP0005377_hearing/vestibular/ear_phenot	1.29182249
34	MP0009250_abnormal_appendicular_skeleto	1.28188570
35	MP0001485_abnormal_pinna_reflex	1.27523628
36	MP0005083_abnormal_biliary_tract	1.26737246
37	MP0005551_abnormal_eye_electrophysiolog	1.23920864
38	MP0001348_abnormal_lacrimal_gland	1.21638102
39	MP0005387_immune_system_phenotype	1.18356539
40	MP0001790_abnormal_immune_system	1.18356539
41	MP0009745_abnormal_behavioral_response	1.18072908
42	MP0005394_taste/olfaction_phenotype	1.17647197
43	MP0005499_abnormal_olfactory_system	1.17647197
44	MP0004036_abnormal_muscle_relaxation	1.16678553
45	MP0001293_anophthalmia	1.14438349
46	MP0005389_reproductive_system_phenotype	1.12214535
47	MP0003123_paternal_imprinting	1.11756827
48	MP0005645_abnormal_hypothalamus_physiol	1.07022509
49	MP0002138_abnormal_hepatobiliary_system	1.05755103
50	MP0003938_abnormal_ear_development	1.04342766
51	MP0004147_increased_porphyrin_level	1.01338213
52	MP0003136_yellow_coat_color	1.01183585
53	MP0002272_abnormal_nervous_system	0.99327060
54	MP0001873_stomach_inflammation	0.98953880
55	MP0001919_abnormal_reproductive_system	0.97314387
56	MP0000678_abnormal_parathyroid_gland	0.96481626
57	MP0003567_abnormal_fetal_cardiomyocyte	0.95378494
58	MP0009785_altered_susceptibility_to	0.94948968
59	MP0000026_abnormal_inner_ear	0.94683752
60	MP0000749_muscle_degeneration	0.89550453
61	MP0002876_abnormal_thyroid_physiology	0.88949268
62	MP0003786_premature_aging	0.88752480
63	MP0006276_abnormal_autonomic_nervous	0.88700909
64	MP0001835_abnormal_antigen_presentation	0.88379191
65	MP0003959_abnormal_lean_body	0.87445459
66	MP0008877_abnormal_DNA_methylation	0.87349163
67	MP0001188_hyperpigmentation	0.87021663
68	MP0002089_abnormal_postnatal_growth/wei	0.86569940
69	MP0002184_abnormal_innervation	0.85519453
70	MP0002106_abnormal_muscle_physiology	0.83892386
71	MP0004130_abnormal_muscle_cell	0.83757304
72	MP0001986_abnormal_taste_sensitivity	0.83653050
73	MP0002733_abnormal_thermal_nociception	0.81602803
74	MP0002249_abnormal_larynx_morphology	0.80503845
75	MP0001963_abnormal_hearing_physiology	0.79721842
76	MP0003936_abnormal_reproductive_system	0.79689684
77	MP0000778_abnormal_nervous_system	0.79360450
78	MP0002108_abnormal_muscle_morphology	0.79200217
79	MP0003879_abnormal_hair_cell	0.77949722
80	MP0002269_muscular_atrophy	0.77083119
81	MP0003011_delayed_dark_adaptation	0.76925598
82	MP0003787_abnormal_imprinting	0.76888898
83	MP0004043_abnormal_pH_regulation	0.75989329
84	MP0005174_abnormal_tail_pigmentation	0.75774735
85	MP0002938_white_spotting	0.75373714
86	MP0003806_abnormal_nucleotide_metabolis	0.74970255
87	MP0001800_abnormal_humoral_immune	0.74145416
88	MP0002210_abnormal_sex_determination	0.74008387
89	MP0003937_abnormal_limbs/digits/tail_de	0.73269035
90	MP0005670_abnormal_white_adipose	0.72533632
91	MP0003880_abnormal_central_pattern	0.70166610
92	MP0001502_abnormal_circadian_rhythm	0.69489810
93	MP0005423_abnormal_somatic_nervous	0.69042959
94	MP0001542_abnormal_bone_strength	0.67877709
95	MP0005195_abnormal_posterior_eye	0.67609109
96	MP0000759_abnormal_skeletal_muscle	0.67594545
97	MP0002752_abnormal_somatic_nervous	0.67150256
98	MP0003186_abnormal_redox_activity	0.66977892
99	MP0004133_heterotaxia	0.65308756
100	MP0002557_abnormal_social/conspecific_i	0.65215893

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.19484593
2	3-Methylglutaconic aciduria (HP:0003535)	4.07777953
3	Palpebral edema (HP:0100540)	3.84812197
4	Abnormality of cells of the erythroid lineage (HP:0012130)	3.83994639
5	Mitochondrial inheritance (HP:0001427)	3.81285765
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.71849051
7	Reticulocytopenia (HP:0001896)	3.63318854
8	Macrocytic anemia (HP:0001972)	3.54244612
9	Acute encephalopathy (HP:0006846)	3.50230915
10	Congenital stationary night blindness (HP:0007642)	3.43552051
11	Progressive macrocephaly (HP:0004481)	3.35841261
12	Increased CSF lactate (HP:0002490)	3.35440101
13	Increased hepatocellular lipid droplets (HP:0006565)	3.33768198
14	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.26582807
15	Abnormality of alanine metabolism (HP:0010916)	3.26582807
16	Hyperalaninemia (HP:0003348)	3.26582807
17	Lipid accumulation in hepatocytes (HP:0006561)	3.24707442
18	Renal Fanconi syndrome (HP:0001994)	3.00530951
19	Stenosis of the external auditory canal (HP:0000402)	2.98586428
20	Pallor (HP:0000980)	2.95819460
21	Absent phalangeal crease (HP:0006109)	2.93986042
22	Abnormal number of erythroid precursors (HP:0012131)	2.92327581
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.83292585
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.78295392
25	Hyperglycinemia (HP:0002154)	2.70161303
26	Cerebral edema (HP:0002181)	2.65112043
27	Hepatocellular necrosis (HP:0001404)	2.63167543
28	Distal arthrogryposis (HP:0005684)	2.54661686
29	Absent thumb (HP:0009777)	2.54067022
30	Septo-optic dysplasia (HP:0100842)	2.52564247
31	Increased intramyocellular lipid droplets (HP:0012240)	2.48061864
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.45126999
33	Abnormal finger flexion creases (HP:0006143)	2.42269857
34	Periorbital edema (HP:0100539)	2.40868067
35	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.39583469
36	Increased IgM level (HP:0003496)	2.38537641
37	Hepatic necrosis (HP:0002605)	2.37447033
38	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.31319333
39	Molar tooth sign on MRI (HP:0002419)	2.31164630
40	Abnormality of midbrain morphology (HP:0002418)	2.31164630
41	Facial edema (HP:0000282)	2.28090463
42	Abnormal drinking behavior (HP:0030082)	2.28043950
43	Polydipsia (HP:0001959)	2.28043950
44	Methylmalonic acidemia (HP:0002912)	2.24308636
45	Maternal diabetes (HP:0009800)	2.24013628
46	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.21806072
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.21806072
48	Exertional dyspnea (HP:0002875)	2.20607868
49	Colon cancer (HP:0003003)	2.19518062
50	Increased serum lactate (HP:0002151)	2.19045335
51	Pancreatic cysts (HP:0001737)	2.18855528
52	Increased muscle lipid content (HP:0009058)	2.15910125
53	Aplastic anemia (HP:0001915)	2.15221419
54	Dyskinesia (HP:0100660)	2.15031186
55	Ulnar deviation of the wrist (HP:0003049)	2.14235299
56	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.13654784
57	Lactic acidosis (HP:0003128)	2.13185275
58	Hypoplasia of the radius (HP:0002984)	2.11946926
59	Pendular nystagmus (HP:0012043)	2.10467151
60	Optic disc pallor (HP:0000543)	2.10360597
61	Pancreatic fibrosis (HP:0100732)	2.07797825
62	Concave nail (HP:0001598)	2.04523078
63	Asplenia (HP:0001746)	2.02916866
64	Calcaneovalgus deformity (HP:0001848)	2.02518537
65	Hypoplasia of the pons (HP:0012110)	2.00052345
66	Abnormality of the renal collecting system (HP:0004742)	1.96852650
67	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96357727
68	Congenital, generalized hypertrichosis (HP:0004540)	1.95089189
69	Partial duplication of the phalanx of hand (HP:0009999)	1.93476335
70	Abnormality of the pons (HP:0007361)	1.93330671
71	True hermaphroditism (HP:0010459)	1.92351655
72	Respiratory difficulties (HP:0002880)	1.91764313
73	Exercise intolerance (HP:0003546)	1.91584942
74	IgG deficiency (HP:0004315)	1.90228633
75	Nephronophthisis (HP:0000090)	1.89740556
76	Deformed tarsal bones (HP:0008119)	1.88560344
77	Methylmalonic aciduria (HP:0012120)	1.87757657
78	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.87499667
79	Abnormality of renal resorption (HP:0011038)	1.86508063
80	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.85810264
81	Carpal bone hypoplasia (HP:0001498)	1.84757860
82	Microretrognathia (HP:0000308)	1.84241854
83	Generalized aminoaciduria (HP:0002909)	1.84064363
84	Abnormality of urine glucose concentration (HP:0011016)	1.81686246
85	Glycosuria (HP:0003076)	1.81686246
86	Hyperphosphaturia (HP:0003109)	1.81634775
87	Forearm undergrowth (HP:0009821)	1.81104350
88	Fibular aplasia (HP:0002990)	1.80626492
89	Hypoplasia of the ulna (HP:0003022)	1.80402419
90	Bile duct proliferation (HP:0001408)	1.79776727
91	Abnormal biliary tract physiology (HP:0012439)	1.79776727
92	Polyuria (HP:0000103)	1.79396456
93	Respiratory failure (HP:0002878)	1.78944331
94	Elevated erythrocyte sedimentation rate (HP:0003565)	1.78546650
95	Constricted visual fields (HP:0001133)	1.77829007
96	Chorioretinal atrophy (HP:0000533)	1.75706596
97	Type 2 muscle fiber atrophy (HP:0003554)	1.74087910
98	Abolished electroretinogram (ERG) (HP:0000550)	1.73302231
99	Abnormality of serum amino acid levels (HP:0003112)	1.73099121
100	Medial flaring of the eyebrow (HP:0010747)	1.72686284

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.93114806
2	TXK	3.33299722
3	BCKDK	3.28846905
4	ADRBK2	2.77530249
5	LIMK1	2.77217212
6	TIE1	2.63781931
7	TLK1	2.57771306
8	KDR	2.54963034
9	STK16	2.54180892
10	STK39	2.24116305
11	OBSCN	2.09038241
12	ZAK	1.88600465
13	GRK1	1.86155560
14	PINK1	1.84740797
15	INSRR	1.82775865
16	PIK3CA	1.82698257
17	CAMKK2	1.81125664
18	PHKG1	1.74283631
19	PHKG2	1.74283631
20	PDK2	1.58838261
21	DYRK2	1.52285276
22	WNK1	1.47418531
23	MAP4K1	1.38535255
24	MAP2K6	1.34136858
25	TESK2	1.29370689
26	MAPK13	1.23150124
27	LRRK2	1.21735023
28	PASK	1.19410049
29	TEC	1.18696697
30	VRK1	1.05127273
31	AURKA	1.05015157
32	PRKCQ	1.03814492
33	NEK2	1.01881066
34	MAP3K11	0.99604149
35	VRK2	0.95508473
36	CAMK1	0.94837743
37	CAMKK1	0.93518625
38	OXSR1	0.90119024
39	ADRBK1	0.89725876
40	MUSK	0.88678358
41	PIM1	0.88134956
42	ITK	0.86964989
43	TAOK3	0.86513056
44	ABL2	0.86484664
45	MAP4K2	0.84271012
46	TESK1	0.82914525
47	NUAK1	0.81951846
48	NTRK3	0.80949871
49	RPS6KA5	0.79533276
50	NME2	0.78716935
51	PRKCG	0.78358528
52	JAK3	0.76193243
53	CHEK2	0.74951214
54	SGK494	0.72547327
55	SGK223	0.72547327
56	LCK	0.71262688
57	NTRK2	0.69582160
58	PRKCH	0.67103114
59	IKBKE	0.64310897
60	PRKACA	0.63656756
61	DYRK1B	0.63458004
62	SYK	0.62548501
63	FRK	0.62220551
64	SGK2	0.61977331
65	NME1	0.61305857
66	ATR	0.61269411
67	CAMK1D	0.60311905
68	TYRO3	0.59914605
69	CSNK2A2	0.58100931
70	CDK4	0.57466326
71	CSNK2A1	0.56626354
72	CDK19	0.56090688
73	CCNB1	0.55750893
74	CAMK2G	0.55445602
75	SGK1	0.53617368
76	PRKCA	0.53593867
77	NEK1	0.52472796
78	PLK4	0.51853272
79	PKN1	0.50575265
80	PRKD2	0.49431987
81	BMPR1B	0.49358433
82	SRPK1	0.49232192
83	MINK1	0.49182909
84	BRAF	0.49028066
85	RPS6KA6	0.48868362
86	CDC7	0.47668214
87	PRKCD	0.46391304
88	WNK3	0.45311974
89	CASK	0.43561141
90	CSNK1A1	0.42099383
91	TNK2	0.42043431
92	IKBKB	0.41919565
93	MAP3K9	0.40875667
94	LYN	0.40308319
95	PIK3CG	0.40196257
96	BTK	0.39382322
97	MARK3	0.39132488
98	MAPK15	0.39107202
99	MAP3K12	0.38364436
100	MAP2K2	0.37746449

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.86261514
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.84397112
3	Sulfur relay system_Homo sapiens_hsa04122	3.64966773
4	Parkinsons disease_Homo sapiens_hsa05012	3.26913169
5	Proteasome_Homo sapiens_hsa03050	2.89113035
6	Alzheimers disease_Homo sapiens_hsa05010	2.36836325
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.32148035
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.21829523
9	Huntingtons disease_Homo sapiens_hsa05016	2.15821370
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.06082157
11	Caffeine metabolism_Homo sapiens_hsa00232	1.87978511
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68731349
13	Regulation of autophagy_Homo sapiens_hsa04140	1.67668886
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.65394418
15	RNA polymerase_Homo sapiens_hsa03020	1.62661462
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.60146847
17	Protein export_Homo sapiens_hsa03060	1.53438712
18	RNA degradation_Homo sapiens_hsa03018	1.53176491
19	Phototransduction_Homo sapiens_hsa04744	1.50119925
20	Allograft rejection_Homo sapiens_hsa05330	1.49394589
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.48874780
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.41296432
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.39723541
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33765530
25	Asthma_Homo sapiens_hsa05310	1.10687513
26	Homologous recombination_Homo sapiens_hsa03440	1.10613813
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10049662
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.06139874
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.04880575
30	Sulfur metabolism_Homo sapiens_hsa00920	1.04502521
31	Basal transcription factors_Homo sapiens_hsa03022	1.04004978
32	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.02795662
33	Type I diabetes mellitus_Homo sapiens_hsa04940	0.98083639
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.97144596
35	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96825858
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94793106
37	DNA replication_Homo sapiens_hsa03030	0.94340899
38	One carbon pool by folate_Homo sapiens_hsa00670	0.93199752
39	Olfactory transduction_Homo sapiens_hsa04740	0.92089566
40	Fat digestion and absorption_Homo sapiens_hsa04975	0.90933848
41	Antigen processing and presentation_Homo sapiens_hsa04612	0.89745421
42	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89303376
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87343570
44	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.87217953
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.86552228
46	Retinol metabolism_Homo sapiens_hsa00830	0.85894345
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.84256231
48	Morphine addiction_Homo sapiens_hsa05032	0.81626697
49	Nicotine addiction_Homo sapiens_hsa05033	0.81053569
50	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.80981224
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77428299
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77167596
53	Purine metabolism_Homo sapiens_hsa00230	0.74667280
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.74155816
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.72006371
56	Butanoate metabolism_Homo sapiens_hsa00650	0.68401800
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.67733919
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.67051785
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64269015
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.64186778
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63257194
62	Spliceosome_Homo sapiens_hsa03040	0.63199525
63	Peroxisome_Homo sapiens_hsa04146	0.61277646
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.60486723
65	Mismatch repair_Homo sapiens_hsa03430	0.59241350
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58880693
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.58534571
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58453906
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.58369177
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.56695041
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56288668
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55683413
73	Metabolic pathways_Homo sapiens_hsa01100	0.52479262
74	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.50342471
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47592624
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46541121
77	Folate biosynthesis_Homo sapiens_hsa00790	0.45984547
78	GABAergic synapse_Homo sapiens_hsa04727	0.45166287
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.42559250
80	Circadian entrainment_Homo sapiens_hsa04713	0.42302358
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42056291
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41237116
83	Serotonergic synapse_Homo sapiens_hsa04726	0.41099524
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40661682
85	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39958493
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39929319
87	Propanoate metabolism_Homo sapiens_hsa00640	0.39605449
88	Base excision repair_Homo sapiens_hsa03410	0.39200793
89	Insulin secretion_Homo sapiens_hsa04911	0.37331952
90	Tight junction_Homo sapiens_hsa04530	0.34684274
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.33240417
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31971031
93	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.30291237
94	Malaria_Homo sapiens_hsa05144	0.28199272
95	Alcoholism_Homo sapiens_hsa05034	0.26578975
96	Taste transduction_Homo sapiens_hsa04742	0.25709162
97	RNA transport_Homo sapiens_hsa03013	0.24508213
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.23805753
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.23559846
100	Measles_Homo sapiens_hsa05162	0.21256160

RPS7P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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