RPS7P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.32297305
2viral transcription (GO:0019083)7.90644382
3translational termination (GO:0006415)7.70756969
4ribosomal small subunit biogenesis (GO:0042274)7.65536078
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.50875917
6translational elongation (GO:0006414)6.42491972
7cotranslational protein targeting to membrane (GO:0006613)6.41423200
8protein targeting to ER (GO:0045047)6.37641201
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.05353201
10protein localization to endoplasmic reticulum (GO:0070972)5.97862359
11cellular protein complex disassembly (GO:0043624)5.85163528
12viral life cycle (GO:0019058)5.79298008
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.77036772
14ATP synthesis coupled proton transport (GO:0015986)5.77036772
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.56030080
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.36024772
17substrate-independent telencephalic tangential migration (GO:0021826)5.30426796
18substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.30426796
19positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.27156739
20maturation of SSU-rRNA (GO:0030490)5.25488419
21chaperone-mediated protein transport (GO:0072321)5.20428711
22establishment of protein localization to mitochondrial membrane (GO:0090151)5.19792777
23protein complex disassembly (GO:0043241)4.93893406
24translational initiation (GO:0006413)4.90342536
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.83563553
26regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.76820497
27protein neddylation (GO:0045116)4.74708676
28macromolecular complex disassembly (GO:0032984)4.72437437
29respiratory electron transport chain (GO:0022904)4.44848453
30regulation of hypersensitivity (GO:0002883)4.43641642
31electron transport chain (GO:0022900)4.38655373
32ribosomal large subunit biogenesis (GO:0042273)4.34957437
33protein targeting to membrane (GO:0006612)4.26546102
34translation (GO:0006412)4.11676461
35behavioral response to nicotine (GO:0035095)4.08245321
36nuclear-transcribed mRNA catabolic process (GO:0000956)4.01763530
37cell proliferation in forebrain (GO:0021846)3.93047562
38neuron fate determination (GO:0048664)3.91506593
39tongue development (GO:0043586)3.82962000
40mRNA catabolic process (GO:0006402)3.77710938
41positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.76358099
42protein complex biogenesis (GO:0070271)3.74951653
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67456536
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.67456536
45NADH dehydrogenase complex assembly (GO:0010257)3.67456536
46regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.65281937
47ribonucleoprotein complex biogenesis (GO:0022613)3.55717141
48L-serine metabolic process (GO:0006563)3.50739330
49mitochondrial respiratory chain complex assembly (GO:0033108)3.48601477
50cellular component biogenesis (GO:0044085)3.46326588
51positive regulation of mast cell degranulation (GO:0043306)3.45364709
52positive regulation of mast cell activation involved in immune response (GO:0033008)3.45364709
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41708514
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41510953
55RNA catabolic process (GO:0006401)3.39215011
56ATP biosynthetic process (GO:0006754)3.37356272
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.25666174
58cardiovascular system development (GO:0072358)3.25477292
59respiratory chain complex IV assembly (GO:0008535)3.25003363
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24090050
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24090050
62purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17530511
63positive regulation of respiratory burst (GO:0060267)3.14383636
64chromatin remodeling at centromere (GO:0031055)3.14378843
65protein-cofactor linkage (GO:0018065)3.08688348
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05430495
67hydrogen ion transmembrane transport (GO:1902600)3.05143023
68ubiquinone biosynthetic process (GO:0006744)3.01910825
69protein targeting (GO:0006605)3.01652427
70positive regulation of T cell apoptotic process (GO:0070234)2.99893086
71establishment of protein localization to membrane (GO:0090150)2.99218982
72cytochrome complex assembly (GO:0017004)2.96678708
73ribonucleoside triphosphate biosynthetic process (GO:0009201)2.95912520
74anterograde synaptic vesicle transport (GO:0048490)2.92482857
75positive regulation of mast cell activation (GO:0033005)2.91769928
76base-excision repair, AP site formation (GO:0006285)2.91475266
77water-soluble vitamin biosynthetic process (GO:0042364)2.90375917
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.90134167
79termination of RNA polymerase III transcription (GO:0006386)2.90134167
80synaptic transmission, cholinergic (GO:0007271)2.90073150
81GTP biosynthetic process (GO:0006183)2.88647533
82kinetochore assembly (GO:0051382)2.88580752
83proton transport (GO:0015992)2.88062539
84somite development (GO:0061053)2.85648364
85protein targeting to mitochondrion (GO:0006626)2.85253466
86regulation of mitochondrial translation (GO:0070129)2.84402277
87establishment of protein localization to mitochondrion (GO:0072655)2.84017560
88pyrimidine nucleotide catabolic process (GO:0006244)2.82940941
89establishment of protein localization to organelle (GO:0072594)2.81879828
90axonemal dynein complex assembly (GO:0070286)2.81630045
91hydrogen transport (GO:0006818)2.81599782
92outer ear morphogenesis (GO:0042473)2.74338817
93platelet dense granule organization (GO:0060155)2.73348962
94ubiquinone metabolic process (GO:0006743)2.71761858
95regulation of cilium movement (GO:0003352)2.70032081
96resolution of meiotic recombination intermediates (GO:0000712)2.69876226
97nucleoside triphosphate biosynthetic process (GO:0009142)2.69242521
98short-term memory (GO:0007614)2.64042940
99protein localization to mitochondrion (GO:0070585)2.60625656
100negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.58028381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41487230
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.57220756
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.22578932
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.73730509
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14597758
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.09536199
7VDR_22108803_ChIP-Seq_LS180_Human2.97741630
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89026628
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81414113
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.67674349
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.67645338
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62087531
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41933631
14IRF1_19129219_ChIP-ChIP_H3396_Human2.17230041
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17141928
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09099416
17IGF1R_20145208_ChIP-Seq_DFB_Human1.90622089
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86829351
19ZNF274_21170338_ChIP-Seq_K562_Hela1.82471084
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79197553
21FOXP3_21729870_ChIP-Seq_TREG_Human1.73276770
22VDR_23849224_ChIP-Seq_CD4+_Human1.68378541
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66945188
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64157732
25TTF2_22483619_ChIP-Seq_HELA_Human1.60751335
26MYC_18940864_ChIP-ChIP_HL60_Human1.54207880
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.51688819
28POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47422033
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46420160
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40484721
31GABP_19822575_ChIP-Seq_HepG2_Human1.39182632
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.36343061
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34385365
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.34005484
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33623509
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33393390
37SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33057890
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.32343851
39XRN2_22483619_ChIP-Seq_HELA_Human1.31785843
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31193336
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28771568
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.28608771
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27791541
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27638221
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.27477883
46ELK1_19687146_ChIP-ChIP_HELA_Human1.23646237
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.22777181
48CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22325941
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22009600
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18099553
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18099220
52NANOG_20526341_ChIP-Seq_ESCs_Human1.17806619
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17313654
54TP53_22573176_ChIP-Seq_HFKS_Human1.17230393
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13176891
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13012820
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09949876
58ERA_21632823_ChIP-Seq_H3396_Human1.06074172
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05397552
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05311498
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05051930
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04512585
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03634774
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02803418
65MYC_19829295_ChIP-Seq_ESCs_Human1.02283970
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.00022881
67TAF2_19829295_ChIP-Seq_ESCs_Human0.99927900
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98416235
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98236676
70P300_19829295_ChIP-Seq_ESCs_Human0.97903730
71AR_20517297_ChIP-Seq_VCAP_Human0.97177737
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96472144
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96443571
74EWS_26573619_Chip-Seq_HEK293_Human0.94655433
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94078593
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93423959
77P53_21459846_ChIP-Seq_SAOS-2_Human0.92604531
78NCOR_22424771_ChIP-Seq_293T_Human0.92254218
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.91775197
80E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90833567
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89279994
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88964964
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88512905
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87051053
85FOXH1_21741376_ChIP-Seq_EPCs_Human0.85307551
86REST_21632747_ChIP-Seq_MESCs_Mouse0.85054327
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84002820
88EED_16625203_ChIP-ChIP_MESCs_Mouse0.83383140
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83174789
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83158779
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82603935
92HOXB7_26014856_ChIP-Seq_BT474_Human0.82541800
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.81760286
94TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81293405
95CBP_20019798_ChIP-Seq_JUKART_Human0.80311409
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80311409
97CTCF_20526341_ChIP-Seq_ESCs_Human0.79824923
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79446346
99FOXP1_21924763_ChIP-Seq_HESCs_Human0.77286116
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.77025956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.04412135
2MP0006292_abnormal_olfactory_placode5.50006519
3MP0003878_abnormal_ear_physiology3.28527114
4MP0005377_hearing/vestibular/ear_phenot3.28527114
5MP0008789_abnormal_olfactory_epithelium3.05313633
6MP0010030_abnormal_orbit_morphology2.87842035
7MP0003122_maternal_imprinting2.78113235
8MP0002837_dystrophic_cardiac_calcinosis2.73973588
9MP0003787_abnormal_imprinting2.53765541
10MP0001293_anophthalmia2.44569025
11MP0005394_taste/olfaction_phenotype2.27280184
12MP0005499_abnormal_olfactory_system2.27280184
13MP0003123_paternal_imprinting2.10828781
14MP0008877_abnormal_DNA_methylation2.00127508
15MP0001485_abnormal_pinna_reflex1.98153426
16MP0000049_abnormal_middle_ear1.97688193
17MP0004142_abnormal_muscle_tone1.95233086
18MP0002234_abnormal_pharynx_morphology1.94616007
19MP0004885_abnormal_endolymph1.79239868
20MP0002160_abnormal_reproductive_system1.78216749
21MP0003646_muscle_fatigue1.77890576
22MP0002938_white_spotting1.76602022
23MP0002653_abnormal_ependyma_morphology1.76017166
24MP0002102_abnormal_ear_morphology1.69322974
25MP0000372_irregular_coat_pigmentation1.65050739
26MP0003938_abnormal_ear_development1.58920286
27MP0003121_genomic_imprinting1.53526190
28MP0008775_abnormal_heart_ventricle1.51376689
29MP0004145_abnormal_muscle_electrophysio1.46126532
30MP0001542_abnormal_bone_strength1.44176624
31MP0009053_abnormal_anal_canal1.38078390
32MP0000631_abnormal_neuroendocrine_gland1.35770804
33MP0002638_abnormal_pupillary_reflex1.29867357
34MP0004147_increased_porphyrin_level1.27532368
35MP0002095_abnormal_skin_pigmentation1.26981642
36MP0006276_abnormal_autonomic_nervous1.25506801
37MP0002249_abnormal_larynx_morphology1.25084714
38MP0000778_abnormal_nervous_system1.24886907
39MP0003567_abnormal_fetal_cardiomyocyte1.24562508
40MP0002233_abnormal_nose_morphology1.23502377
41MP0003186_abnormal_redox_activity1.19569538
42MP0002163_abnormal_gland_morphology1.18320567
43MP0005174_abnormal_tail_pigmentation1.15121506
44MP0005389_reproductive_system_phenotype1.14523886
45MP0005408_hypopigmentation1.14110494
46MP0005360_urolithiasis1.12099678
47MP0002272_abnormal_nervous_system1.11628848
48MP0003136_yellow_coat_color1.09144649
49MP0005248_abnormal_Harderian_gland1.07839142
50MP0003755_abnormal_palate_morphology1.07183037
51MP0005075_abnormal_melanosome_morpholog1.07160374
52MP0001529_abnormal_vocalization1.05265650
53MP0003942_abnormal_urinary_system1.05262448
54MP0005551_abnormal_eye_electrophysiolog1.04967668
55MP0000026_abnormal_inner_ear1.03872831
56MP0000678_abnormal_parathyroid_gland1.00642341
57MP0005195_abnormal_posterior_eye1.00442379
58MP0001286_abnormal_eye_development0.98531952
59MP0001986_abnormal_taste_sensitivity0.98507548
60MP0001905_abnormal_dopamine_level0.97815879
61MP0003937_abnormal_limbs/digits/tail_de0.97262366
62MP0002697_abnormal_eye_size0.97145417
63MP0000566_synostosis0.94713880
64MP0008875_abnormal_xenobiotic_pharmacok0.91584592
65MP0003879_abnormal_hair_cell0.86806638
66MP0003011_delayed_dark_adaptation0.85655065
67MP0002752_abnormal_somatic_nervous0.84558752
68MP0008872_abnormal_physiological_respon0.83448490
69MP0001984_abnormal_olfaction0.82883793
70MP0003119_abnormal_digestive_system0.81848149
71MP0002736_abnormal_nociception_after0.81278207
72MP0002177_abnormal_outer_ear0.80383923
73MP0001324_abnormal_eye_pigmentation0.78389819
74MP0005670_abnormal_white_adipose0.78168526
75MP0000230_abnormal_systemic_arterial0.77220086
76MP0001663_abnormal_digestive_system0.76815445
77MP0002210_abnormal_sex_determination0.76801753
78MP0000647_abnormal_sebaceous_gland0.76730790
79MP0001968_abnormal_touch/_nociception0.76417139
80MP0000343_altered_response_to0.75576672
81MP0001963_abnormal_hearing_physiology0.74123431
82MP0000428_abnormal_craniofacial_morphol0.72907924
83MP0004133_heterotaxia0.72221704
84MP0002557_abnormal_social/conspecific_i0.72023353
85MP0006036_abnormal_mitochondrial_physio0.72009729
86MP0001919_abnormal_reproductive_system0.71745211
87MP0003315_abnormal_perineum_morphology0.71661858
88MP0003385_abnormal_body_wall0.70785798
89MP0002282_abnormal_trachea_morphology0.69059790
90MP0005423_abnormal_somatic_nervous0.68455786
91MP0002184_abnormal_innervation0.67356597
92MP0003936_abnormal_reproductive_system0.65786626
93MP0009250_abnormal_appendicular_skeleto0.65111254
94MP0009745_abnormal_behavioral_response0.64977066
95MP0002822_catalepsy0.64691697
96MP0003693_abnormal_embryo_hatching0.64486131
97MP0002092_abnormal_eye_morphology0.64071555
98MP0003880_abnormal_central_pattern0.62400947
99MP0005646_abnormal_pituitary_gland0.60879356
100MP0002132_abnormal_respiratory_system0.60708733

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.75461147
2Septo-optic dysplasia (HP:0100842)5.33161805
3Abnormality of cells of the erythroid lineage (HP:0012130)4.74629139
4Acute necrotizing encephalopathy (HP:0006965)4.56109781
5Macrocytic anemia (HP:0001972)4.29035072
6Acute encephalopathy (HP:0006846)4.18405993
7Type 2 muscle fiber atrophy (HP:0003554)4.09761786
8Abnormal mitochondria in muscle tissue (HP:0008316)4.01856058
9Muscle fiber atrophy (HP:0100295)3.79726351
10Progressive macrocephaly (HP:0004481)3.69207050
11Mitochondrial inheritance (HP:0001427)3.63840223
12Abnormal number of erythroid precursors (HP:0012131)3.63756864
13Absent septum pellucidum (HP:0001331)3.57664546
14Increased CSF lactate (HP:0002490)3.18226901
15Pallor (HP:0000980)3.09795906
16Colon cancer (HP:0003003)2.99949438
17Hyperglycinemia (HP:0002154)2.94327959
18Maternal diabetes (HP:0009800)2.82612729
19Absent rod-and cone-mediated responses on ERG (HP:0007688)2.82309080
20Cerebral edema (HP:0002181)2.80728468
21Hepatocellular necrosis (HP:0001404)2.64838582
22Optic nerve hypoplasia (HP:0000609)2.57956635
23Abnormality of the septum pellucidum (HP:0007375)2.57076422
24Stenosis of the external auditory canal (HP:0000402)2.53530416
25Abnormality of placental membranes (HP:0011409)2.52082333
26Amniotic constriction ring (HP:0009775)2.52082333
27Calcaneovalgus deformity (HP:0001848)2.51917830
28Medial flaring of the eyebrow (HP:0010747)2.46746472
29Abnormality of midbrain morphology (HP:0002418)2.46357565
30Molar tooth sign on MRI (HP:0002419)2.46357565
3111 pairs of ribs (HP:0000878)2.44394273
32Hyperthyroidism (HP:0000836)2.43070322
33Growth hormone deficiency (HP:0000824)2.40157111
34Oligodactyly (HP:0012165)2.40003096
35Increased hepatocellular lipid droplets (HP:0006565)2.39668754
36Depressed nasal ridge (HP:0000457)2.37974547
37Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.35085898
38Abnormal rod and cone electroretinograms (HP:0008323)2.34566057
393-Methylglutaconic aciduria (HP:0003535)2.32916747
40Popliteal pterygium (HP:0009756)2.32036807
41Anophthalmia (HP:0000528)2.31983592
42Rib fusion (HP:0000902)2.31910378
43Lipid accumulation in hepatocytes (HP:0006561)2.31709280
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.30867603
45Absent/shortened dynein arms (HP:0200106)2.30867603
46Abnormality of alanine metabolism (HP:0010916)2.28816568
47Hyperalaninemia (HP:0003348)2.28816568
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28816568
49Absent phalangeal crease (HP:0006109)2.27231122
50Adrenal hypoplasia (HP:0000835)2.26072084
51Absent thumb (HP:0009777)2.23992609
52Increased serum lactate (HP:0002151)2.19949352
53Nephrogenic diabetes insipidus (HP:0009806)2.19709084
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19124231
55Deformed tarsal bones (HP:0008119)2.18590587
56Lactic acidosis (HP:0003128)2.17699232
57Hepatic necrosis (HP:0002605)2.17637105
58True hermaphroditism (HP:0010459)2.17487179
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15189330
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15189330
61Hypoplasia of the radius (HP:0002984)2.14583805
62Poor suck (HP:0002033)2.14302554
63Hyperglycinuria (HP:0003108)2.14009791
64Sclerocornea (HP:0000647)2.13873020
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13244009
66Oligodactyly (hands) (HP:0001180)2.12774449
67Pancreatic fibrosis (HP:0100732)2.12738722
68Myokymia (HP:0002411)2.07908029
69Optic disc pallor (HP:0000543)2.07833781
70Pancreatic cysts (HP:0001737)2.05457651
71Congenital primary aphakia (HP:0007707)2.02775187
72Type II lissencephaly (HP:0007260)2.02484133
73Renal dysplasia (HP:0000110)2.02237412
74Leukodystrophy (HP:0002415)2.02204325
75Abnormal ciliary motility (HP:0012262)2.00515539
76Respiratory failure (HP:0002878)1.99525056
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.98131184
78Gait imbalance (HP:0002141)1.97963704
79Fetal akinesia sequence (HP:0001989)1.96021617
80Triphalangeal thumb (HP:0001199)1.95707491
81Patent foramen ovale (HP:0001655)1.95654754
82Congenital, generalized hypertrichosis (HP:0004540)1.94869435
83Abnormal finger flexion creases (HP:0006143)1.94248991
84Abnormality of the labia minora (HP:0012880)1.94241599
85Abolished electroretinogram (ERG) (HP:0000550)1.93272785
86Abnormal respiratory epithelium morphology (HP:0012253)1.92869172
87Abnormal respiratory motile cilium morphology (HP:0005938)1.92869172
88Abnormal respiratory motile cilium physiology (HP:0012261)1.92362122
89Asplenia (HP:0001746)1.92121535
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91058521
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.87994915
92Partial duplication of thumb phalanx (HP:0009944)1.86310291
93Anencephaly (HP:0002323)1.86219200
94Occipital encephalocele (HP:0002085)1.86179644
95Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85592798
96Renal Fanconi syndrome (HP:0001994)1.84702220
97Congenital stationary night blindness (HP:0007642)1.83535576
98Ectopic kidney (HP:0000086)1.83138446
99Forearm undergrowth (HP:0009821)1.80237119
100Vaginal atresia (HP:0000148)1.79973215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.59802874
2CDK194.27944518
3TIE13.75669185
4ARAF3.75183127
5MAP3K92.87718603
6PIK3CA2.60495552
7MAP3K122.31134534
8BRAF2.24692169
9DYRK22.22176708
10MAP4K22.09276085
11NEK11.99818454
12WNK31.82186471
13NME21.75079975
14ADRBK21.72819119
15ZAK1.71147252
16GRK11.69361755
17CDC71.67678695
18MAP3K111.53065455
19OXSR11.51857753
20LIMK11.50179247
21LRRK21.48572810
22NUAK11.44636135
23PIM21.43674674
24WNK41.26121925
25CSNK1G21.18974520
26PRKCG1.17846072
27KDR1.17643466
28EPHB21.16329193
29DMPK1.14014844
30MAP2K71.06052017
31PLK41.05872235
32MARK31.05386718
33BCKDK1.04904882
34BMPR1B1.04609410
35TLK11.00967894
36TNIK0.98057374
37AURKB0.96206046
38OBSCN0.96184598
39MAP2K40.95910912
40CAMK1D0.91747735
41STK390.90758637
42PASK0.88577747
43TRIM280.86886032
44PRKCI0.86324743
45VRK20.86091188
46EPHA40.84341104
47TYRO30.80571458
48CAMK10.79775765
49CASK0.76096927
50FRK0.73868413
51CSNK1G30.72776235
52DAPK30.71737168
53VRK10.71371753
54PIK3CG0.70358422
55DYRK1B0.67154303
56PDK20.66629245
57PRKCQ0.66311294
58CAMK1G0.65802543
59ACVR1B0.65515186
60NTRK20.65231255
61EIF2AK10.65205145
62DYRK30.64406251
63ABL20.64236133
64CSNK2A20.62496597
65TAF10.58190061
66PLK10.57844140
67MAPK130.57555811
68MAP3K40.57124851
69NME10.56718596
70INSRR0.56604067
71PINK10.55281836
72PRKACA0.54602729
73RPS6KA50.54439863
74IKBKE0.53529528
75AURKA0.53227143
76TEC0.52370905
77RPS6KA60.49808551
78CSNK2A10.49525318
79CAMK2D0.48423903
80CSNK1G10.47101284
81MINK10.46910066
82CSNK1A1L0.46348331
83CDK140.45656109
84STK110.45312223
85PIM10.44574012
86CDK11A0.43709949
87PRKCE0.42805375
88PLK30.39400283
89CAMK2A0.39274103
90MAP3K130.38797033
91CSNK1A10.38373174
92UHMK10.38172853
93PRKCA0.36738933
94MAP2K60.35511698
95SGK10.35194221
96RPS6KL10.34871314
97RPS6KC10.34871314
98CDK150.34023086
99MAP3K100.32384673
100CAMK2G0.32212861

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.10496092
2Oxidative phosphorylation_Homo sapiens_hsa001904.84257197
3Parkinsons disease_Homo sapiens_hsa050124.15165253
4Huntingtons disease_Homo sapiens_hsa050162.93540040
5Cardiac muscle contraction_Homo sapiens_hsa042602.90446773
6Alzheimers disease_Homo sapiens_hsa050102.79413562
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.71623288
8RNA polymerase_Homo sapiens_hsa030202.47020612
9Asthma_Homo sapiens_hsa053102.29785267
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12225374
11Proteasome_Homo sapiens_hsa030502.00839501
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97636889
13Homologous recombination_Homo sapiens_hsa034401.77093431
14Linoleic acid metabolism_Homo sapiens_hsa005911.74743455
15Mismatch repair_Homo sapiens_hsa034301.68116113
16Protein export_Homo sapiens_hsa030601.66617283
17Fat digestion and absorption_Homo sapiens_hsa049751.58617384
18Selenocompound metabolism_Homo sapiens_hsa004501.55134025
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52199821
20RNA degradation_Homo sapiens_hsa030181.46804536
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39775541
22Sulfur relay system_Homo sapiens_hsa041221.38284279
23Pyrimidine metabolism_Homo sapiens_hsa002401.34792874
24Fanconi anemia pathway_Homo sapiens_hsa034601.32909560
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30984336
26Basal transcription factors_Homo sapiens_hsa030221.25948038
27Nucleotide excision repair_Homo sapiens_hsa034201.24323944
28Nicotine addiction_Homo sapiens_hsa050331.15363394
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14765204
30DNA replication_Homo sapiens_hsa030301.11417595
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09906910
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07873914
33Base excision repair_Homo sapiens_hsa034101.01711921
34Arachidonic acid metabolism_Homo sapiens_hsa005900.87317310
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86056119
36Phototransduction_Homo sapiens_hsa047440.85814806
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81061546
38Tryptophan metabolism_Homo sapiens_hsa003800.80559072
39Propanoate metabolism_Homo sapiens_hsa006400.79201330
40Metabolic pathways_Homo sapiens_hsa011000.77442044
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75928622
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73575530
43Pyruvate metabolism_Homo sapiens_hsa006200.72720120
44Purine metabolism_Homo sapiens_hsa002300.71981457
45Spliceosome_Homo sapiens_hsa030400.67935019
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66573095
47Fatty acid degradation_Homo sapiens_hsa000710.64687061
48Basal cell carcinoma_Homo sapiens_hsa052170.64145311
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63514265
50Ether lipid metabolism_Homo sapiens_hsa005650.58404141
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56745237
52RNA transport_Homo sapiens_hsa030130.56265835
53Chemical carcinogenesis_Homo sapiens_hsa052040.56114053
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55543967
55Morphine addiction_Homo sapiens_hsa050320.53766265
56Hedgehog signaling pathway_Homo sapiens_hsa043400.53029213
57Folate biosynthesis_Homo sapiens_hsa007900.51929994
58Retinol metabolism_Homo sapiens_hsa008300.51357864
59Steroid biosynthesis_Homo sapiens_hsa001000.50893750
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.50423439
61Collecting duct acid secretion_Homo sapiens_hsa049660.50286347
62Vitamin B6 metabolism_Homo sapiens_hsa007500.49489346
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49085495
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.49047896
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.49005141
66One carbon pool by folate_Homo sapiens_hsa006700.48739817
67Sulfur metabolism_Homo sapiens_hsa009200.48626220
68Butanoate metabolism_Homo sapiens_hsa006500.47140346
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46227012
70Tyrosine metabolism_Homo sapiens_hsa003500.45619424
71Histidine metabolism_Homo sapiens_hsa003400.44969287
72Vitamin digestion and absorption_Homo sapiens_hsa049770.42619855
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42583680
74Nitrogen metabolism_Homo sapiens_hsa009100.41484791
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39596291
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38971146
77Arginine and proline metabolism_Homo sapiens_hsa003300.38560718
78Olfactory transduction_Homo sapiens_hsa047400.38257936
79Fatty acid elongation_Homo sapiens_hsa000620.38239524
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38073217
81Glycerolipid metabolism_Homo sapiens_hsa005610.37942082
82Peroxisome_Homo sapiens_hsa041460.36447297
83Glutathione metabolism_Homo sapiens_hsa004800.34143341
84beta-Alanine metabolism_Homo sapiens_hsa004100.32112905
85Fatty acid biosynthesis_Homo sapiens_hsa000610.31197264
86Ovarian steroidogenesis_Homo sapiens_hsa049130.30107404
87Pancreatic secretion_Homo sapiens_hsa049720.29250615
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28512232
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.27367536
90Hippo signaling pathway_Homo sapiens_hsa043900.24184539
91Rheumatoid arthritis_Homo sapiens_hsa053230.23270409
92Biosynthesis of amino acids_Homo sapiens_hsa012300.22730716
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21359493
94Caffeine metabolism_Homo sapiens_hsa002320.17609419
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.17596316
96Systemic lupus erythematosus_Homo sapiens_hsa053220.15955302
97Insulin secretion_Homo sapiens_hsa049110.15901291
98Glutamatergic synapse_Homo sapiens_hsa047240.14295880
99Autoimmune thyroid disease_Homo sapiens_hsa053200.14162819
100Allograft rejection_Homo sapiens_hsa053300.13089708

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